Detailed information for compound 1846430

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.237 | Formula: C11H14F2N2O4
  • H donors: 3 H acceptors: 3 LogP: -0.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@](C[C@@H]1O)(C)n1cc(F)c(c(c1=O)F)N
  • InChi: 1S/C11H14F2N2O4/c1-11(2-6(17)7(4-16)19-11)15-3-5(12)9(14)8(13)10(15)18/h3,6-7,16-17H,2,4,14H2,1H3/t6-,7+,11-/m0/s1
  • InChiKey: QAVBZUWYDJQFBK-CVJICSNFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.1193 0.5901 0.5901
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0017 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Entamoeba histolytica aminopeptidase, putative 0.0089 0.0382 0.111
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1681 0.8339 0.8339
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0039 0.5
Echinococcus granulosus cathepsin l1 0.0016 0.0017 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0248 0.0701
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0248 0.0701
Echinococcus granulosus leukotriene A 4 hydrolase 0.1681 0.8339 0.8339
Trichomonas vaginalis AGC family protein kinase 0.0615 0.3009 0.9107
Schistosoma mansoni cpg binding protein 0.0089 0.0378 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0016 0.0013
Leishmania major protein kinase, putative 0.0615 0.3009 0.9107
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0382 0.0966
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0079 0.0189
Schistosoma mansoni hypothetical protein 0.0363 0.1748 0.1748
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0035 0.0111 0.0287
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.0578 0.0578
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0673 0.3302 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0046 0.0046
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0673 0.3302 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0079 0.0189
Loa Loa (eye worm) aminopeptidase N 0.0089 0.0382 0.0451
Loa Loa (eye worm) hypothetical protein 0.0089 0.0382 0.0451
Echinococcus multilocularis mitogen activated protein kinase 3 0.0063 0.0252 0.0252
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.119 0.1422
Brugia malayi CXXC zinc finger family protein 0.0084 0.0354 0.0893
Echinococcus multilocularis aminopeptidase N 0.0089 0.0382 0.0382
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0673 0.3302 0.3302
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.0252 0.0714
Loa Loa (eye worm) ctsf protein 0.0016 0.0017 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0111 0.0111
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0089 0.0382 0.111
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0297 0.0297
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0039 0.0065
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0039 0.0039
Plasmodium falciparum serine/threonine protein kinase, putative 0.0615 0.3009 0.9107
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0017
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0039 0.0065
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0759 0.5787
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0111 0.0111
Leishmania major cathepsin L-like protease 0.0062 0.0248 0.0701
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0673 0.3302 1
Brugia malayi hypothetical protein 0.0089 0.0382 0.0966
Schistosoma mansoni lamin 0.003 0.0087 0.0087
Brugia malayi Pre-SET motif family protein 0.0036 0.0115 0.0261
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0673 0.3302 1
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Leishmania major hypothetical protein, conserved 0.0029 0.0079 0.0189
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0673 0.3302 0.3302
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0079 0.0189
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.119 0.3103
Toxoplasma gondii aminopeptidase n, putative 0.0089 0.0382 0.111
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0382 0.111
Giardia lamblia Aurora kinase 0.0615 0.3009 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.01 0.01
Brugia malayi serine/threonine kinase 12 0.0615 0.3009 0.7911
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0039 0.004
Loa Loa (eye worm) AUR protein kinase 0.0615 0.3009 0.3604
Schistosoma mansoni intermediate filament proteins 0.003 0.0087 0.0087
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0382 0.111
Entamoeba histolytica protein kinase, putative 0.0615 0.3009 0.9107
Loa Loa (eye worm) hypothetical protein 0.003 0.0087 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0063 0.0252 0.0714
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Echinococcus multilocularis lamin dm0 0.003 0.0087 0.0087
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0382 0.111
Brugia malayi hypothetical protein 0.014 0.0636 0.1637
Toxoplasma gondii aminopeptidase N protein 0.0089 0.0382 0.111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Trypanosoma cruzi Aminopeptidase M1, putative 0.0089 0.0382 0.111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0179 0.083 0.083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0803 0.2392
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Trypanosoma brucei aurora B kinase 0.0615 0.3009 0.9102
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0673 0.3302 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0615 0.3009 0.9107
Loa Loa (eye worm) peptidase family M1 containing protein 0.0089 0.0382 0.0451
Brugia malayi intermediate filament protein 0.003 0.0087 0.0186
Onchocerca volvulus 0.003 0.0087 0.0542
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0382 0.111
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0673 0.3302 1
Brugia malayi Cytochrome P450 family protein 0.0021 0.0039 0.0059
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0089 0.0382 0.0382
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0221 0.0619
Trichomonas vaginalis AGC family protein kinase 0.0615 0.3009 0.9107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0578 1
Brugia malayi Pre-SET motif family protein 0.024 0.1134 0.2955
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0252 0.0252
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0017 0.0017
Brugia malayi hypothetical protein 0.0019 0.0028 0.0032
Mycobacterium ulcerans aminopeptidase N PepN 0.0089 0.0382 0.6368
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0046 0.0046
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0046 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0156 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Leishmania major cytochrome p450-like protein 0.0021 0.0039 0.0065
Echinococcus granulosus aurora kinase A 0.0615 0.3009 0.3009
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0115 0.0115
Toxoplasma gondii aminopeptidase N, putative 0.0089 0.0382 0.111
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0039 0.0065
Loa Loa (eye worm) AUR protein kinase 0.0615 0.3009 0.3604
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Brugia malayi hypothetical protein 0.0035 0.0111 0.0251
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0039
Mycobacterium leprae putative cytochrome p450 0.0021 0.0039 0.5
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Brugia malayi RNA binding protein 0.0072 0.0297 0.0743
Brugia malayi hypothetical protein 0.0089 0.0382 0.0966
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0156 0.0156
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0008 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0156 0.037
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0039 0.0065
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0382 0.111
Brugia malayi Cytochrome P450 family protein 0.0021 0.0039 0.0059
Schistosoma mansoni aminopeptidase A (M01 family) 0.0089 0.0382 0.0382
Echinococcus multilocularis musashi 0.003 0.0087 0.0087
Echinococcus multilocularis 0.0021 0.0039 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0252 0.0714
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0089 0.0382 0.111
Onchocerca volvulus 0.0036 0.0115 0.0764
Echinococcus granulosus intermediate filament protein 0.003 0.0087 0.0087
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0063 0.0252 0.0714
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0115 0.0115
Onchocerca volvulus 0.0084 0.0354 0.2629
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Trichomonas vaginalis AGC family protein kinase 0.0615 0.3009 0.9107
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0089 0.0382 0.111
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0089 0.0382 0.111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0156 0.0156
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.0252 0.0714
Entamoeba histolytica hypothetical protein 0.0035 0.0111 0.0287
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0382 0.111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0087 0.0097
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Trichomonas vaginalis helicase, putative 0.0019 0.003 0.0039
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1681 0.8339 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0248 0.0701
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0115 0.0298
Brugia malayi cytochrome P450 0.0021 0.0039 0.0059
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0673 0.3302 0.8686
Loa Loa (eye worm) hypothetical protein 0.0089 0.0382 0.0451
Trypanosoma brucei aminopeptidase, putative 0.0089 0.0382 0.1052
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0017 0.0014
Leishmania major cytochrome p450-like protein 0.0021 0.0039 0.0065
Echinococcus multilocularis aurora kinase A 0.0615 0.3009 0.3009
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0089 0.0382 0.111
Echinococcus multilocularis geminin 0.0363 0.1748 0.1748
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.0578 0.1705
Schistosoma mansoni hypothetical protein 0.0021 0.0039 0.0039
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.0578 0.0578
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0252 0.0714
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0089 0.0382 0.111
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.007 0.014
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0382 0.0966
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0089 0.0382 0.111
Trypanosoma brucei Aminopeptidase M1, putative 0.0089 0.0382 0.1052
Trichomonas vaginalis AGC family protein kinase 0.0615 0.3009 0.9107
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.0017
Leishmania major cathepsin L-like protease 0.0062 0.0248 0.0701
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0089 0.0382 0.111
Echinococcus multilocularis microtubule associated protein 2 0.2013 1 1
Schistosoma mansoni protein kinase 0.0615 0.3009 0.3009
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Loa Loa (eye worm) TATA binding protein associated factor 0.0089 0.0382 0.0451
Brugia malayi MAP kinase sur-1 0.0063 0.0252 0.0622
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0089 0.0382 0.0382
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0803 0.2392
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0017 0.0017
Entamoeba histolytica protein kinase, putative 0.0615 0.3009 0.9107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0089 0.0382 0.0382
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0079 0.0125
Entamoeba histolytica hypothetical protein 0.0035 0.0111 0.0287
Echinococcus multilocularis lamin 0.003 0.0087 0.0087
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0673 0.3302 0.3302
Trypanosoma cruzi aminopeptidase, putative 0.0089 0.0382 0.111
Onchocerca volvulus 0.0089 0.0382 0.2845
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0035 0.0111 0.0111
Plasmodium vivax SET domain protein, putative 0.0036 0.0115 0.0298
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0382 0.111
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0063 0.0252 0.0714
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0039 0.004
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.0017
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0063 0.0252 0.0653
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0115 0.0115
Brugia malayi Cytochrome P450 family protein 0.0021 0.0039 0.0059
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0087 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0252 0.0714
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0079 0.0189
Echinococcus multilocularis cpg binding protein 0.0089 0.0378 0.0378
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Loa Loa (eye worm) hypothetical protein 0.014 0.0636 0.0756
Echinococcus multilocularis dnaJ subfamily B 0.1193 0.5901 0.5901
Toxoplasma gondii aurora kinase 0.0615 0.3009 0.9107
Onchocerca volvulus 0.003 0.0087 0.0542
Echinococcus granulosus lamin dm0 0.003 0.0087 0.0087
Schistosoma mansoni cytochrome P450 0.0021 0.0039 0.0039
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0673 0.3302 1
Loa Loa (eye worm) cytochrome P450 0.0021 0.0039 0.004
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0131
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0089 0.0382 0.1052
Brugia malayi TAR-binding protein 0.0072 0.0297 0.0743
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.0017
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0297 0.035
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0156 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Brugia malayi serine/threonine-protein kinase 6 0.0615 0.3009 0.7911
Brugia malayi TATA binding protein associated factor 0.0089 0.0382 0.0966
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0115 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0039 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0578 1
Trypanosoma cruzi aminopeptidase, putative 0.0089 0.0382 0.111
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0115 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0115 0.0115
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0063 0.0252 0.0714
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0115 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Loa Loa (eye worm) CXXC zinc finger family protein 0.0084 0.0354 0.0418
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0017
Onchocerca volvulus 0.0273 0.1299 1
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0673 0.3302 1
Echinococcus multilocularis mitogen activated protein kinase 0.0063 0.0252 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0578 1
Loa Loa (eye worm) RNA binding protein 0.0072 0.0297 0.035
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0673 0.3302 1
Echinococcus granulosus dnaJ subfamily B 0.1193 0.5901 0.5901
Toxoplasma gondii histone lysine methyltransferase SET1 0.016 0.0735 0.2186
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.0578 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0382 0.0966
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0297 0.0743
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Onchocerca volvulus 0.0089 0.0382 0.2845
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0071 0.0071
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0297 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0156 0.0156
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Entamoeba histolytica protein kinase , putative 0.0615 0.3009 0.9107
Echinococcus granulosus cpg binding protein 0.0089 0.0378 0.0378
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0673 0.3302 0.3956
Schistosoma mansoni cpg binding protein 0.0089 0.0378 0.0378
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0615 0.3009 0.3009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Schistosoma mansoni lamin 0.003 0.0087 0.0087
Entamoeba histolytica hypothetical protein 0.0035 0.0111 0.0287
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0071 0.0079
Schistosoma mansoni microtubule-associated protein tau 0.2013 1 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0615 0.3009 0.9107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0003
Trypanosoma brucei protein kinase, putative 0.0063 0.0252 0.0653
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0252 0.0714
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.1134 0.1354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0156 0.0156
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.0578 0.0578
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Loa Loa (eye worm) cysteine protease 0.0016 0.0017 0.0014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1571 0.7793 0.7793
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0673 0.3302 0.8686
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0156 0.0181
Schistosoma mansoni cpg binding protein 0.0084 0.0354 0.0354
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0071 0.0071
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0248 0.0701
Loa Loa (eye worm) fibroinase 0.0016 0.0017 0.0014
Echinococcus granulosus tar DNA binding protein 0.0072 0.0297 0.0297
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0039 0.004
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0063 0.0252 0.0295
Loa Loa (eye worm) AUR protein kinase 0.0615 0.3009 0.3604
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0615 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0002 0.0002
Onchocerca volvulus 0.0089 0.0382 0.2845
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0673 0.3302 0.3956
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Loa Loa (eye worm) cytochrome P450 family protein 0.0095 0.041 0.0485
Entamoeba histolytica protein kinase domain containing protein 0.0615 0.3009 0.9107
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0111 0.0111
Echinococcus granulosus aminopeptidase N 0.0089 0.0382 0.0382
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0673 0.3302 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0039 0.0065
Brugia malayi Cytochrome P450 family protein 0.0095 0.041 0.104
Mycobacterium ulcerans aminopeptidase N PepN 0.0089 0.0382 0.6368
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0008 0.0008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0363 0.1748 0.1748
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0089 0.0382 0.111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0046 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.0578 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0636 0.0756
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0079 0.0189
Leishmania major cathepsin L-like protease 0.0062 0.0248 0.0701
Echinococcus granulosus mitogen activated protein kinase 0.0063 0.0252 0.0252
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0039 0.0065
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Leishmania major cytochrome p450-like protein 0.0021 0.0039 0.0065
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0181 0.0498
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0615 0.3009 0.9107
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0079 0.0189
Trypanosoma cruzi aurora B kinase, putative 0.0615 0.3009 0.9107
Echinococcus granulosus lamin 0.003 0.0087 0.0087
Loa Loa (eye worm) intermediate filament protein 0.003 0.0087 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0089
Echinococcus granulosus geminin 0.0363 0.1748 0.1748
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0017 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0615 0.3009 0.3009
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1681 0.8339 0.8339
Echinococcus granulosus mitogen activated protein kinase 3 0.0063 0.0252 0.0252
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.0017
Brugia malayi hypothetical protein 0.0029 0.0079 0.0167
Loa Loa (eye worm) hypothetical protein 0.0089 0.0382 0.0451
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0089 0.0382 0.0382
Onchocerca volvulus Huntingtin homolog 0.014 0.0636 0.4826
Trypanosoma brucei Aminopeptidase M1, putative 0.0089 0.0382 0.1052
Onchocerca volvulus Huntingtin homolog 0.014 0.0636 0.4826
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0615 0.3009 0.9107
Brugia malayi serine/threonine protein kinase 6 0.0615 0.3009 0.7911
Brugia malayi hypothetical protein 0.0773 0.3799 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0063 0.0252 0.0714
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.0578 0.1705
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Trichomonas vaginalis set domain proteins, putative 0.0273 0.1299 0.3901

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) > 1 M Compound was tested for its inhibitory activity against L1210 lymphoid leukemia cells at 10 ug/mL ChEMBL. 3806615
T/C (functional) < 125 % Compound was tested for mean survival time of treated mice in days / mean survival time of control mice x 100 against L1210 lymphoid leukemia cells ChEMBL. 3806615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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