Detailed information for compound 1861912

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 482.476 | Formula: C20H34O13
  • H donors: 7 H acceptors: 8 LogP: -2.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@@H]1O[C@@H](O[C@@H]2CCCC[C@H]2O[C@@H]2O[C@@H](C)[C@H]([C@@H]([C@@H]2O)O)O)[C@H]([C@H]([C@H]1O)OCC(=O)O)O
  • InChi: 1S/C20H34O13/c1-8-13(24)15(26)16(27)19(30-8)31-9-4-2-3-5-10(9)32-20-17(28)18(29-7-12(22)23)14(25)11(6-21)33-20/h8-11,13-21,24-28H,2-7H2,1H3,(H,22,23)/t8-,9+,10+,11-,13+,14-,15-,16-,17-,18-,19-,20+/m0/s1
  • InChiKey: HVTRYWRQFYDADL-WOPCHQDYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0136 0.075 0.0856
Brugia malayi beta-lactamase family protein 0.0037 0.0085 0.0097
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0072 0.0321 0.0468
Echinococcus granulosus tar DNA binding protein 0.0071 0.0313 0.0527
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0236 0.0269
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0087 0.0422 0.0711
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0045 0.0051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.0321 0.2142
Leishmania major eukaryotic initiation factor 4a, putative 0.0789 0.5131 1
Brugia malayi CXXC zinc finger family protein 0.0064 0.0267 0.0304
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0052 0.019 0.037
Echinococcus granulosus eukaryotic initiation factor 4A 0.0789 0.5131 0.8646
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0028 0.0024 0.0041
Trichomonas vaginalis set domain proteins, putative 0.1514 1 1
Brugia malayi Sodium:solute symporter family protein 0.0043 0.0129 0.0148
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0422 0.0822
Schistosoma mansoni inositol transporter 0.0043 0.0129 0.0218
Schistosoma mansoni hypothetical protein 0.0033 0.0061 0.0102
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.1188 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0168 0.0283
Echinococcus multilocularis high affinity choline transporter 1 0.0392 0.2472 0.4166
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.083 0.0946
Schistosoma mansoni kinase 0.0055 0.0206 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Brugia malayi PHD-finger family protein 0.0032 0.0054 0.0061
Treponema pallidum ATP-dependent RNA helicase 0.0789 0.5131 1
Brugia malayi jmjC domain containing protein 0.0045 0.014 0.016
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0313 0.0527
Schistosoma mansoni phd/f-box containing protein 0.0045 0.014 0.0236
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0591 0.1004
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0186 0.0307
Toxoplasma gondii ABC1 family protein 0.0037 0.0085 0.0166
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0789 0.5131 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0789 0.5131 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0192 0.1128 0.19
Echinococcus granulosus L aminoadipate semialdehyde 0.0186 0.1086 0.1831
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0201 0.1188 0.2002
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.0558 0.094
Brugia malayi Heterochromatin protein 1 0.0147 0.0823 0.0939
Schistosoma mansoni survival motor neuron protein 0.0053 0.0197 0.0331
Echinococcus granulosus peregrin 0.0087 0.0422 0.0711
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.0436 0.2765 0.3154
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.0321 0.2142
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0313 0.0527
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0133 0.0733 0.0836
Schistosoma mansoni phosphatidylserine receptor 0.0045 0.014 0.0236
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.0869 0.7109
Schistosoma mansoni hypothetical protein 0.0495 0.3163 0.533
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0168 0.0283
Echinococcus granulosus cpg binding protein 0.0067 0.0291 0.0491
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0558 0.0558
Onchocerca volvulus 0.0037 0.0085 0.0085
Plasmodium falciparum thioredoxin reductase 0.0049 0.0169 0.0329
Onchocerca volvulus 0.0024 0.000000053587 0.000000053587
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0088 0.0433 0.0433
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.083 0.1398
Onchocerca volvulus 0.0436 0.2765 0.2765
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.1188 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0186 0.0201
Brugia malayi Cytochrome P450 family protein 0.0108 0.0565 0.0645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.0321 0.0366
Schistosoma mansoni jumonji domain containing protein 0.0289 0.178 0.3
Loa Loa (eye worm) hypothetical protein 0.0033 0.0061 0.0069
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0267 0.0304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.083 0.1398
Brugia malayi eukaryotic initiation factor 4A 0.0789 0.5131 0.5852
Echinococcus granulosus high affinity choline transporter 1 0.0392 0.2472 0.4166
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0284 0.0394
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0024 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0085 0.0109
Plasmodium vivax RNA helicase-1, putative 0.0789 0.5131 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0172 0.0993 0.1674
Loa Loa (eye worm) heterochromatin protein 1 0.0147 0.0823 0.0939
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.014 0.016
Loa Loa (eye worm) glutathione reductase 0.0049 0.0169 0.0193
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0186 0.0212
Brugia malayi MAP kinase sur-1 0.0052 0.0186 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.023 0.023
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0284 0.0394
Brugia malayi Pre-SET motif family protein 0.1331 0.8768 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0045 0.014 0.0273
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0348 0.2173 0.3661
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0056 0.0108
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0112 0.0189
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0201 0.1188 0.2002
Echinococcus granulosus solute carrier family 5 0.0043 0.0129 0.0218
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0789 0.5131 0.8646
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0313 0.0527
Echinococcus multilocularis mucolipin 3 0.0072 0.0322 0.0543
Schistosoma mansoni hypothetical protein 0.0087 0.0422 0.0711
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0168 0.0164
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0186 0.0314
Echinococcus granulosus sodium:glucose cotransporter 2 0.0043 0.0129 0.0218
Trichomonas vaginalis chromobox protein, putative 0.0147 0.0823 0.0823
Echinococcus multilocularis L aminoadipate semialdehyde 0.0186 0.1086 0.1831
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.083 0.1398
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0192 0.1128 0.19
Toxoplasma gondii thioredoxin reductase 0.0049 0.0169 0.0329
Loa Loa (eye worm) hypothetical protein 0.0392 0.2472 0.282
Echinococcus granulosus neuropeptide s receptor 0.0511 0.3268 0.5507
Entamoeba histolytica hypothetical protein 0.0041 0.0112 0.0219
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0061
Brugia malayi Coelomocyte uptake defective protein 5 0.0072 0.0322 0.0368
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0052 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.014 0.016
Schistosoma mansoni protein phosphatase 2C 0.0045 0.014 0.0236
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0128 0.0192
Loa Loa (eye worm) hypothetical protein 0.0261 0.1592 0.1816
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0018 0.0021
Echinococcus multilocularis Polycystic kidney disease protein 0.0028 0.0026 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0196 0.0196
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0018 0.0031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0072 0.0321 0.0542
Trypanosoma cruzi PAB1-binding protein , putative 0.0083 0.0399 0.0622
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.014 0.0109
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.014 0.0109
Leishmania major hypothetical protein, conserved 0.0045 0.014 0.0109
Loa Loa (eye worm) runx1 0.0055 0.0206 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.023 0.023
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0168 0.0327
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0168 0.0283
Onchocerca volvulus 0.0031 0.0045 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.1948 0.1948
Plasmodium falciparum glutathione reductase 0.0049 0.0169 0.0329
Echinococcus granulosus JmjC domain containing protein 4 0.0045 0.014 0.0236
Loa Loa (eye worm) jmjC domain-containing protein 0.0172 0.0993 0.1133
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0052 0.019 0.5
Onchocerca volvulus 0.0053 0.0197 0.0197
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0789 0.5131 0.8646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.083 0.1398
Onchocerca volvulus 0.0037 0.0085 0.0085
Brugia malayi hypothetical protein 0.0261 0.1592 0.1816
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.054 0.0615
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0789 0.5131 0.5131
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0049 0.0168 0.0327
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0049 0.0168 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0186 0.0314
Echinococcus multilocularis Chromobox protein 3 0.0024 0.000000053587 0.000000090304
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0085 0.0085
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.075 0.0856
Schistosoma mansoni hypothetical protein 0.0908 0.5934 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0061 0.0069
Echinococcus granulosus dnaJ subfamily B 0.0908 0.5934 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.0321 0.0542
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0085 0.0143
Echinococcus granulosus lamin dm0 0.0031 0.0045 0.0075
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0097 0.0097
Echinococcus multilocularis neuropeptide receptor A26 0.0511 0.3268 0.5507
Echinococcus granulosus sodium:myo inositol cotransporter 0.0043 0.0129 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.083 0.1398
Brugia malayi glutathione reductase 0.0049 0.0169 0.0193
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0168 0.0283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.1948 0.1948
Entamoeba histolytica hypothetical protein 0.0041 0.0112 0.0219
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0789 0.5131 1
Leishmania major cathepsin L-like protease 0.0066 0.0284 0.0394
Plasmodium falciparum JmjC domain-containing protein, putative 0.0045 0.014 0.0273
Giardia lamblia Fructose-bisphosphate aldolase 0.0314 0.1948 0.3563
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0097 0.0097
Echinococcus granulosus GPCR family 2 0.0033 0.0061 0.0102
Brugia malayi SET domain containing protein 0.0032 0.0056 0.0064
Leishmania major hypothetical protein, conserved 0.0083 0.0399 0.0622
Brugia malayi isocitrate dehydrogenase 0.0049 0.0168 0.0191
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0591 0.1004
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0313 0.0527
Plasmodium vivax SET domain protein, putative 0.0192 0.1128 0.2198
Trichomonas vaginalis esterase, putative 0.0037 0.0085 0.0085
Schistosoma mansoni inositol transporter 0.0043 0.0129 0.0218
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0082 0.0391 0.0391
Trypanosoma brucei polo-like protein kinase 0.0107 0.0558 0.1035
Loa Loa (eye worm) hypothetical protein 0.0045 0.014 0.016
Echinococcus granulosus intermediate filament protein 0.0031 0.0045 0.0075
Brugia malayi AF-10 protein 0.0028 0.0029 0.0034
Brugia malayi chromobox protein homolog 3 0.0082 0.0391 0.0446
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0789 0.5131 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0789 0.5131 0.5131
Schistosoma mansoni aldehyde dehydrogenase 0.0201 0.1188 0.2002
Brugia malayi hypothetical protein 0.0054 0.02 0.0228
Schistosoma mansoni hypothetical protein 0.0053 0.0197 0.0331
Onchocerca volvulus 0.0031 0.0045 0.0045
Brugia malayi Cytochrome P450 family protein 0.0043 0.0128 0.0145
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0591 0.1004
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0186
Plasmodium falciparum phd finger protein, putative 0.0087 0.0422 0.0822
Onchocerca volvulus Alhambra homolog 0.0087 0.0422 0.0422
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0558 0.0558
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0318 0.0363
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0313 0.0357
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0142 0.0794 0.1338
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0052 0.019 0.0207
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0052 0.019 0.0949
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.083 0.0946
Loa Loa (eye worm) hypothetical protein 0.0166 0.0951 0.1085
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0284 0.0394
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0192 0.1128 0.19
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0107 0.0558 0.0937
Schistosoma mansoni aldehyde dehydrogenase 0.0201 0.1188 0.2002
Leishmania major trypanothione reductase 0.0049 0.0169 0.0166
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0789 0.5131 0.8646
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0168 0.0327
Schistosoma mansoni lipoxygenase 0.0061 0.0249 0.0419
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0192 0.1128 0.2198
Plasmodium falciparum eukaryotic initiation factor 4A 0.0789 0.5131 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0186 0.0201
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.1188 1
Echinococcus granulosus jumonji domain containing 1A 0.0045 0.014 0.0236
Loa Loa (eye worm) hypothetical protein 0.0083 0.0399 0.0455
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.019 0.0314
Schistosoma mansoni chromobox protein 0.0147 0.0823 0.1387
Brugia malayi GH02984p 0.0392 0.2472 0.282
Loa Loa (eye worm) hypothetical protein 0.0192 0.1128 0.1286
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0097 0.0097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.054 0.0615
Mycobacterium tuberculosis Probable reductase 0.0112 0.0591 0.1004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0192 0.1128 0.19
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0186 0.0314
Echinococcus multilocularis chromobox protein 1 0.0147 0.0823 0.1387
Leishmania major cathepsin L-like protease 0.0066 0.0284 0.0394
Brugia malayi beta-lactamase 0.0037 0.0085 0.0097
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.0558 0.094
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0591 0.1004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.1948 0.1948
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.1948 0.1948
Loa Loa (eye worm) CHromoDomain protein family member 0.0028 0.0024 0.0028
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0052 0.019 0.037
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0558 0.0558
Echinococcus multilocularis jumonji domain containing 1A 0.0045 0.014 0.0236
Schistosoma mansoni hypothetical protein 0.0028 0.0029 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0558 0.0558
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0043 0.0129 0.0218
Echinococcus granulosus lysine specific demethylase 6a 0.0045 0.014 0.0236
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.009 0.0152
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0045 0.014 0.0217
Brugia malayi RNA binding protein 0.0071 0.0313 0.0357
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0128 0.0385
Echinococcus multilocularis GPCR, family 2 0.0033 0.0061 0.0102
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0028 0.0024 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0201 0.1188 0.2186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0097 0.0097
Echinococcus multilocularis dnaJ subfamily B 0.0908 0.5934 1
Echinococcus granulosus Chromobox protein 3 0.0024 0.000000053587 0.000000090304
Loa Loa (eye worm) hypothetical protein 0.0789 0.5131 0.5852
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0675 0.753
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0047
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0029 0.0057
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0032 0.0056 0.0108
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0049 0.0165 0.0277
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0422 0.0822
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0186 0.0363
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.0869 0.1554
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0196 0.0196
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0168 0.0191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0192 0.1128 0.19
Brugia malayi hypothetical protein 0.0436 0.2765 0.3154
Loa Loa (eye worm) hypothetical protein 0.0064 0.0271 0.031
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0097
Loa Loa (eye worm) hypothetical protein 0.0133 0.0733 0.0836
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0186 0.0201
Echinococcus multilocularis lamin 0.0031 0.0045 0.0075
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.0558 0.0937
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.0321 0.0542
Brugia malayi jmjC domain containing protein 0.0348 0.2173 0.2478
Brugia malayi PHD-finger family protein 0.0087 0.0422 0.0481
Onchocerca volvulus 0.0043 0.0129 0.0129
Echinococcus granulosus chromobox protein 1 0.0147 0.0823 0.1387
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.075 0.0856
Leishmania major cytochrome p450-like protein 0.0043 0.0128 0.0084
Loa Loa (eye worm) mucolipin 1 0.0072 0.0322 0.0368
Echinococcus granulosus Polycystic kidney disease protein 0.0028 0.0026 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Onchocerca volvulus Huntingtin homolog 0.0133 0.0733 0.0733
Echinococcus multilocularis lysine specific demethylase 5A 0.0168 0.0969 0.1633
Brugia malayi intermediate filament protein 0.0031 0.0045 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0697 0.1358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Schistosoma mansoni hypothetical protein 0.0071 0.0318 0.0536
Trypanosoma cruzi PAB1-binding protein , putative 0.0083 0.0399 0.0622
Brugia malayi hypothetical protein 0.0083 0.0399 0.0455
Echinococcus multilocularis lamin dm0 0.0031 0.0045 0.0075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0085 0.0143
Trichomonas vaginalis chromobox protein, putative 0.0088 0.0433 0.0433
Loa Loa (eye worm) jmjC domain-containing protein 0.0179 0.1043 0.1189
Loa Loa (eye worm) hypothetical protein 0.0045 0.014 0.016
Echinococcus multilocularis solute carrier family 5 0.0043 0.0129 0.0218
Loa Loa (eye worm) hypothetical protein 0.0087 0.0422 0.0481
Echinococcus granulosus PHD finger protein rhinoceros 0.0087 0.0422 0.0711
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0169 0.0193
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.014 0.016
Brugia malayi jmjC domain containing protein 0.0045 0.014 0.016
Schistosoma mansoni intermediate filament proteins 0.0031 0.0045 0.0075
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0789 0.5131 0.8646
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0097
Echinococcus granulosus sodium:glucose cotransporter 0.0043 0.0129 0.0218
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0018 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.054 0.0615
Loa Loa (eye worm) hypothetical protein 0.0071 0.0318 0.0363
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0061 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0052 0.0052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0061 0.0102
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0128 0.0145
Echinococcus multilocularis jumonji domain containing protein 0.0121 0.065 0.1096
Schistosoma mansoni hypothetical protein 0.0033 0.0061 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0216 0.1289 0.2172
Schistosoma mansoni cpg binding protein 0.0067 0.0291 0.0491
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0186 0.1086 0.1239
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0168 0.0283
Leishmania major cathepsin L-like protease 0.0066 0.0284 0.0394
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0313 0.0527
Echinococcus granulosus mucolipin 3 0.0072 0.0322 0.0543
Brugia malayi Bromodomain containing protein 0.0087 0.0422 0.0481
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0085 0.0085
Giardia lamblia Kinase, PLK 0.0107 0.0558 0.0751
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0789 0.5131 1
Schistosoma mansoni hypothetical protein 0.0033 0.0061 0.0102
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0045 0.014 0.0273
Echinococcus multilocularis peregrin 0.0087 0.0422 0.0711
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.1948 0.1948
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.1948 0.1948
Brugia malayi jmjC domain containing protein 0.0045 0.014 0.016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.083 0.1398
Echinococcus granulosus lysine specific demethylase 5A 0.0172 0.0993 0.1674
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0675 0.117
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0051
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0052 0.019 0.037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0097 0.0097
Brugia malayi hypothetical protein 0.0133 0.0733 0.0836
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0045 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.1948 0.1948
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.0558 0.0937
Onchocerca volvulus 0.0216 0.1289 0.1289
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0052 0.019 0.5
Schistosoma mansoni lamin 0.0031 0.0045 0.0075
Trypanosoma brucei PAB1-binding protein , putative 0.0083 0.0399 0.0724
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0422 0.0822
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0128 0.0145
Onchocerca volvulus 0.0186 0.1086 0.1086
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0313 0.0357
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0051 0.0183 0.0308
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0789 0.5131 0.5131
Trypanosoma brucei trypanothione reductase 0.0049 0.0169 0.0273
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0197 0.0224
Loa Loa (eye worm) hypothetical protein 0.0104 0.054 0.0615
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0028 0.0029 0.0057
Echinococcus granulosus lamin 0.0031 0.0045 0.0075
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0591 0.1004
Schistosoma mansoni hypothetical protein 0.0041 0.0112 0.0189
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0168 0.0164
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0789 0.5131 0.5131
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.1592 0.2684
Plasmodium vivax ataxin-2 like protein, putative 0.0083 0.0399 0.0777
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0186 0.1086 0.1831
Echinococcus multilocularis phd:f box containing protein 0.0045 0.014 0.0236
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0097
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0169 0.0284
Loa Loa (eye worm) beta-lactamase 0.0037 0.0085 0.0097
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0085 0.0143
Schistosoma mansoni sodium/solute symporter 0.0043 0.0129 0.0218
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0085 0.0166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0061 0.0102
Loa Loa (eye worm) hypothetical protein 0.0186 0.1086 0.1239
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0112 0.0189
Brugia malayi Pre-SET motif family protein 0.0192 0.1128 0.1286
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0128 0.0084
Mycobacterium leprae conserved hypothetical protein 0.0052 0.019 0.1335
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0168 0.0271
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0072 0.0321 0.0468
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0186 0.0201
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0313 0.0527
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0348 0.2173 0.3661
Echinococcus multilocularis geminin 0.0495 0.3163 0.533
Schistosoma mansoni lozenge 0.0055 0.0206 0.0347
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0249 0.0419
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.1948 0.1948
Echinococcus granulosus neuropeptide receptor A26 0.0511 0.3268 0.5507
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1331 0.8768 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0083 0.0399 0.0777
Brugia malayi F/Y-rich N-terminus family protein 0.0055 0.0207 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0789 0.5131 0.8646
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.0869 1
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0391 0.0391
Schistosoma mansoni polycystin 1-related 0.0028 0.0026 0.0043
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0675 0.117
Schistosoma mansoni hypothetical protein 0.0037 0.009 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0391 0.0391
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0284 0.0394
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0168 0.0283
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0558 0.0558
Giardia lamblia PHD finger protein 15 0.0087 0.0422 0.0477
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0052 0.019 0.037
Echinococcus multilocularis lysine specific demethylase 6a 0.0045 0.014 0.0236
Brugia malayi Thioredoxin reductase 0.0049 0.0169 0.0193
Loa Loa (eye worm) hypothetical protein 0.0436 0.2765 0.3154
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0186
Brugia malayi Cytochrome P450 family protein 0.0043 0.0128 0.0145
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0789 0.5131 1
Onchocerca volvulus Huntingtin homolog 0.0133 0.0733 0.0733
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0168 0.0327
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0168 0.0283
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0085 0.0085
Schistosoma mansoni jumonji domain containing protein 0.0045 0.014 0.0236
Loa Loa (eye worm) RNA binding protein 0.0071 0.0313 0.0357
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0168 0.0271
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0189 0.0206
Brugia malayi CHD4 protein 0.0028 0.0024 0.0028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0097 0.0097
Onchocerca volvulus 0.0037 0.0085 0.0085
Echinococcus multilocularis Protein lozenge 0.0055 0.0206 0.0347
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.0558 0.0636
Echinococcus granulosus jumonji domain containing protein 0.0121 0.065 0.1096
Schistosoma mansoni high-affinity choline transporter 0.0392 0.2472 0.4166
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0085 0.0097
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0186 0.0314
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0314 0.1948 0.3797
Onchocerca volvulus 0.0064 0.0267 0.0267
Loa Loa (eye worm) cytochrome P450 family protein 0.0108 0.0565 0.0645
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0043 0.0129 0.0218
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0097
Onchocerca volvulus 0.0064 0.0271 0.0271
Schistosoma mansoni mucolipin 0.0072 0.0322 0.0543
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0049 0.0165 0.0277
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.1411 0.2629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0591 0.6459
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0085 0.0085
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0201 0.1188 0.2186
Schistosoma mansoni mucolipin 0.0066 0.0282 0.0475
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0558 0.0558
Schistosoma mansoni lamin 0.0031 0.0045 0.0075
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0245 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0789 0.5131 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0085 0.0097
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.1592 0.2684
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.009 0.0152
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0675 0.117
Echinococcus multilocularis musashi 0.0031 0.0045 0.0075
Echinococcus granulosus phd:f box containing protein 0.0045 0.014 0.0236
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0186 0.0201
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0043 0.0129 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Loa Loa (eye worm) PHD-finger family protein 0.0087 0.0422 0.0481
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0558 0.094
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0097 0.0097
Echinococcus multilocularis cpg binding protein 0.0067 0.0291 0.0491
Plasmodium falciparum ataxin-2 like protein, putative 0.0083 0.0399 0.0777
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0168 0.0191
Loa Loa (eye worm) CYP4Cod1 0.0043 0.0128 0.0145
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0061 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0169 0.0166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0085 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0097 0.0097
Toxoplasma gondii aldehyde dehydrogenase 0.0201 0.1188 0.2316
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0314 0.1948 0.3797
Schistosoma mansoni hypothetical protein 0.0495 0.3163 0.533
Echinococcus granulosus chromobox protein 1 0.0147 0.0823 0.1387
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0043 0.0129 0.0218
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0249 0.0419
Schistosoma mansoni hypothetical protein 0.0033 0.0061 0.0102
Echinococcus multilocularis chromobox protein 1 0.0147 0.0823 0.1387
Brugia malayi TAR-binding protein 0.0071 0.0313 0.0357
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.083 0.1398
Echinococcus granulosus geminin 0.0495 0.3163 0.533
Brugia malayi jmjC domain containing protein 0.0172 0.0993 0.1133
Loa Loa (eye worm) hypothetical protein 0.0043 0.0129 0.0148
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0045 0.014 0.0236
Trypanosoma brucei protein kinase, putative 0.0052 0.0186 0.0307
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0313 0.0357
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0186 0.0314
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0192 0.1128 0.19
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0186 0.0201
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0061 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0284 0.0499
Treponema pallidum fructose-bisphosphate aldolase 0.0314 0.1948 0.3558
Brugia malayi beta-lactamase family protein 0.0037 0.0085 0.0097
Entamoeba histolytica hypothetical protein 0.0052 0.019 0.037
Echinococcus multilocularis JmjC domain containing protein 4 0.0045 0.014 0.0236
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0169 0.0284
Plasmodium vivax JmjC domain containing protein 0.0045 0.014 0.0273
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0052 0.019 0.0949
Brugia malayi jmjC domain containing protein 0.0045 0.014 0.016
Entamoeba histolytica hypothetical protein 0.0041 0.0112 0.0219
Schistosoma mansoni jumonji/arid domain-containing protein 0.0172 0.0993 0.1674
Toxoplasma gondii LsmAD domain-containing protein 0.0083 0.0399 0.0777
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0184 0.1071 0.1805
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0169 0.0329
Entamoeba histolytica hypothetical protein 0.0041 0.0112 0.0219
Schistosoma mansoni chromobox protein 0.0147 0.0823 0.1387
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0128 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0085 0.0085
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.0558 0.0558
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0186
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.0558 0.1087
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0789 0.5131 1
Echinococcus multilocularis neuropeptide s receptor 0.0511 0.3268 0.5507
Brugia malayi hypothetical protein 0.0041 0.0112 0.0128
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.0558 0.0636
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0558 0.0558
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0061 0.0102
Echinococcus multilocularis PHD finger protein rhinoceros 0.0087 0.0422 0.0711
Trichomonas vaginalis chromobox protein, putative 0.0147 0.0823 0.0823
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0043 0.0129 0.0218
Schistosoma mansoni cpg binding protein 0.0064 0.0267 0.045
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0169 0.0166
Trichomonas vaginalis chromobox protein, putative 0.0088 0.0433 0.0433
Plasmodium vivax glutathione reductase, putative 0.0049 0.0169 0.0329
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0112 0.0189
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0446
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0168 0.0164
Schistosoma mansoni cpg binding protein 0.0067 0.0291 0.0491
Leishmania major phosphopantetheinyl transferase-like protein 0.0052 0.019 0.0207

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.5 mM Inhibitory concentration of the compound against E-selectin ChEMBL. 11412987
IC50 (binding) > 10 mM Compound was tested for its ability to inhibit the binding to recombinant human Selectin E immobilized on SPA beads of radiolabelled HL60 cell membrane containing sLex. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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