Detailed information for compound 2000503

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 427.459 | Formula: C23H21N7O2
  • H donors: 5 H acceptors: 5 LogP: 1.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](c1cccc2c1[nH]cc2)NC(=O)Nc1ncc2c(c1)[nH]nc2c1ccnc(c1)C
  • InChi: 1S/C23H21N7O2/c1-13-9-15(6-7-24-13)22-17-11-26-20(10-18(17)29-30-22)28-23(32)27-19(12-31)16-4-2-3-14-5-8-25-21(14)16/h2-11,19,25,31H,12H2,1H3,(H,29,30)(H2,26,27,28,32)/t19-/m0/s1
  • InChiKey: JYKZDDPLDORJKW-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.016 0.0349 0.7719
Echinococcus multilocularis GPCR, family 2 0.004 0.0059 0.019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0126 0.0266 0.0825
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0058 0.0184
Brugia malayi hypothetical protein 0.0033 0.0042 0.0122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0038
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0107 0.0221 0.074
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0123 0.0378
Brugia malayi beta-lactamase family protein 0.002 0.0012 0.0028
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Loa Loa (eye worm) hypothetical protein 0.0045 0.0072 0.0218
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0041 0.0133
Echinococcus multilocularis sodium and chloride dependent glycine 0.0073 0.0139 0.0461
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Loa Loa (eye worm) steroid hormone receptor 0.0214 0.0477 0.1488
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0058 0.0184
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0073 0.0139 0.0849
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0112 0.0321
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0073 0.0139 0.0428
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0058 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0058 0.0189
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0058 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0221 0.0663
Echinococcus granulosus g protein coupled receptor 0.0039 0.0058 0.0189
Schistosoma mansoni coup transcription factor 0.0214 0.0477 0.0474
Loa Loa (eye worm) hypothetical protein 0.0113 0.0235 0.0728
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0112 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0214 0.0477 0.1488
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.2913
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0101 0.0206 0.0637
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0018 0.0015
Schistosoma mansoni zinc finger protein 0.0101 0.0206 0.0203
Schistosoma mansoni nuclear receptor 0.0101 0.0206 0.0203
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Giardia lamblia hypothetical protein 0.0107 0.0221 0.1148
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.0023 0.0063
Brugia malayi jmjC domain containing protein 0.0019 0.001 0.0021
Schistosoma mansoni amine GPCR 0.0039 0.0058 0.0055
Schistosoma mansoni hypothetical protein 0.0336 0.0771 0.0768
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0058 0.0171
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0138 0.0296 0.0989
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0101 0.0206 0.0686
Plasmodium vivax hypothetical protein, conserved 0.002 0.0012 0.0118
Schistosoma mansoni amine GPCR 0.0039 0.0058 0.0055
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0107 0.0221 0.0683
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0058 0.0189
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0027 0.0027 0.0083
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.001 0.0022
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0101 0.0206 0.0637
Echinococcus granulosus peregrin 0.0032 0.0041 0.0133
Echinococcus granulosus neuropeptide receptor 0.0039 0.0058 0.0189
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0112 0.0372
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Schistosoma mansoni ets-related 0.0151 0.0326 0.0323
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0073 0.0139 0.0461
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0058 0.0189
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0428
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0428
Brugia malayi Steroid receptor seven-up type 2 0.0214 0.0477 0.1488
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0135 0.0132
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0107 0.0221 0.0663
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0073 0.0139 0.0466
Brugia malayi Nuclear hormone receptor-like 1 0.0113 0.0235 0.0728
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.001 0.0027
Brugia malayi hypothetical protein 0.0101 0.0206 0.0637
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0058 0.0184
Brugia malayi hypothetical protein 0.0101 0.0206 0.0637
Echinococcus granulosus lamin 0.0046 0.0074 0.0246
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.001 0.0027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0214 0.0477 0.0474
Brugia malayi photoreceptor-specific nuclear receptor 0.0214 0.0477 0.1488
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0683 0.1606 0.5414
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0058 0.0189
Loa Loa (eye worm) hypothetical protein 0.0214 0.0477 0.1488
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0058 0.0184
Echinococcus multilocularis FTZ F1 alpha 0.0214 0.0477 0.1602
Echinococcus multilocularis lipoxygenase domain containing protein 0.0033 0.0042 0.0132
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.0266 0.0887
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0112 0.0321
Onchocerca volvulus 0.0039 0.0058 0.0181
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0112 0.0372
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0058 0.0055
Onchocerca volvulus 0.0039 0.0058 0.0181
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0138 0.0296 0.0993
Brugia malayi Fli-1 protein 0.0151 0.0326 0.1014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0214 0.0477 0.1606
Loa Loa (eye worm) intermediate filament protein 0.0046 0.0074 0.0224
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0214 0.0477 0.1602
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0041 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.0233 0.023
Loa Loa (eye worm) hypothetical protein 0.0996 0.2358 0.7385
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0107 0.0221 0.0683
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0058 0.0055
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0058 0.0189
Echinococcus granulosus Polycystic kidney disease protein 0.0033 0.0042 0.0137
Loa Loa (eye worm) hypothetical protein 0.0214 0.0477 0.1488
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1342 0.3192 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0073 0.0139 0.0137
Onchocerca volvulus 0.0039 0.0058 0.0181
Schistosoma mansoni hypothetical protein 0.0033 0.0042 0.0039
Brugia malayi jmjC domain containing protein 0.0019 0.001 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0221 0.0663
Brugia malayi Latrophilin receptor protein 2 0.004 0.0059 0.0177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0214 0.0477 0.1488
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0107 0.0221 0.2849
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0058 0.0171
Brugia malayi neuropeptide F receptor 0.0039 0.0058 0.0171
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0107 0.0221 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0135 0.0132
Brugia malayi ORL1-like opioid receptor 0.0039 0.0058 0.0171
Echinococcus granulosus chromobox protein 1 0.0038 0.0055 0.0182
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.002 0.0012 0.0028
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0059 0.0177
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0431 0.0999 0.3125
Schistosoma mansoni biogenic amine receptor 0.0039 0.0058 0.0055
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Loa Loa (eye worm) norepinephrine transporter 0.0431 0.0999 0.3125
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0107 0.0221 0.0735
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0136 0.0133
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0073 0.0139 0.0428
Schistosoma mansoni hypothetical protein 0.0039 0.0058 0.0055
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0058 0.0184
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Schistosoma mansoni lamin 0.0046 0.0074 0.0071
Onchocerca volvulus 0.0431 0.0999 0.3363
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0041 0.0509
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0112 0.2468
Schistosoma mansoni neuropeptide receptor 0.0039 0.0058 0.0055
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0214 0.0477 0.1602
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1248 0.2964 1
Brugia malayi nuclear hormone receptor 0.0101 0.0206 0.0637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0214 0.0477 0.1488
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0112 0.0321
Schistosoma mansoni rab6-interacting 0.0033 0.0042 0.0039
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Loa Loa (eye worm) solute carrier family 6 member 4 0.0431 0.0999 0.3125
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Plasmodium vivax phosphodiesterase gamma, putative 0.0107 0.0221 0.2913
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0022 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0015 0.0333
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0139 0.0428
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0683 0.1606 0.5414
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0058 0.0184
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.2913
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.0197
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0107 0.0221 0.0735
Echinococcus multilocularis serotonin receptor 0.0642 0.1508 0.5084
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0293 0.0668 0.2087
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0058 0.0171
Brugia malayi jmjC domain containing protein 0.0019 0.001 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.002 0.0012 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.016 0.0349 0.7719
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0107 0.0221 0.0218
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0058 0.0055
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0107 0.0221 0.074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0058 0.0055
Onchocerca volvulus 0.0039 0.0058 0.0181
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0058 0.0171
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Brugia malayi G-protein coupled receptor 0.0039 0.0058 0.0171
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Schistosoma mansoni phd/f-box containing protein 0.0019 0.001 0.0007
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Plasmodium falciparum phosphodiesterase gamma, putative 0.0107 0.0221 0.2849
Toxoplasma gondii cathepsin CPC1 0.0327 0.075 0.4653
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0221 0.4882
Leishmania major hypothetical protein, conserved 0.002 0.0012 0.0007
Echinococcus granulosus phd:f box containing protein 0.0019 0.001 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0058 0.0189
Schistosoma mansoni chromobox protein 0.0038 0.0055 0.0052
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0327 0.075 1
Schistosoma mansoni loxhd1 0.0033 0.0042 0.0039
Leishmania major cAMP-specific phosphodiesterase, putative 0.0107 0.0221 0.0663
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0177
Echinococcus granulosus serotonin receptor 0.0039 0.0058 0.0189
Brugia malayi Dopamine receptor protein 1 0.0039 0.0058 0.0171
Toxoplasma gondii hypothetical protein 0.0073 0.0139 0.0849
Echinococcus granulosus hypothetical protein 0.0039 0.0058 0.0189
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0058 0.0184
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0058 0.0184
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0058 0.0184
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0214 0.0477 0.1606
Loa Loa (eye worm) hypothetical protein 0.0113 0.0235 0.0728
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0214 0.0477 0.1488
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0058 0.0184
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0107 0.0221 0.0218
Schistosoma mansoni hypothetical protein 0.004 0.0059 0.0056
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0022 0.0017 0.0044
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.001 0.0022
Loa Loa (eye worm) doublecortin family protein 0.0033 0.0042 0.0122
Schistosoma mansoni amine GPCR 0.0039 0.0058 0.0055
Schistosoma mansoni lipoxygenase 0.0067 0.0125 0.0122
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0139 0.0137
Brugia malayi nuclear receptor RXR 0.0113 0.0235 0.0728
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0139 0.0428
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0058 0.0189
Schistosoma mansoni opsin-like receptor 0.0039 0.0058 0.0055
Onchocerca volvulus 0.0033 0.0042 0.0128
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0044
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Schistosoma mansoni nuclear receptor 0.0101 0.0206 0.0203
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Schistosoma mansoni hypothetical protein 0.0039 0.0058 0.0055
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0058 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis RUN 0.0033 0.0042 0.0132
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0107 0.0221 0.074
Schistosoma mansoni hypothetical protein 0.004 0.0059 0.0056
Onchocerca volvulus 0.0039 0.0058 0.0181
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0576 0.1349 0.4545
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0019 0.0419
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0058 0.0055
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0028
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0112 0.0676
Loa Loa (eye worm) hypothetical protein 0.0107 0.0221 0.0683
Loa Loa (eye worm) PDE1B protein 0.0107 0.0221 0.0683
Brugia malayi Doublecortin family protein 0.0033 0.0042 0.0122
Loa Loa (eye worm) fli-1 protein 0.0151 0.0326 0.1014
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0017 0.0053
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Onchocerca volvulus 0.0214 0.0477 0.1599
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0101 0.0206 0.0203
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0022 0.0019
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0073 0.0139 0.0849
Loa Loa (eye worm) hypothetical protein 0.0686 0.1613 0.5051
Schistosoma mansoni neuropeptide receptor 0.0039 0.0058 0.0055
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0214 0.0477 0.1488
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.001 0.0021
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0214 0.0477 0.1488
Echinococcus granulosus GA binding protein alpha chain 0.005 0.0083 0.0275
Toxoplasma gondii cathepsin CPC2 0.0124 0.0262 0.1613
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0214 0.0477 0.1602
Brugia malayi TAR-binding protein 0.0071 0.0135 0.0413
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0221 0.0663
Toxoplasma gondii ABC1 family protein 0.002 0.0012 0.0055
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0021 0.0015 0.0038
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0683 0.1606 1
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0058 0.0189
Echinococcus granulosus RUN 0.0033 0.0042 0.0137
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0058 0.0189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0112 0.0233 0.0782
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0028
Schistosoma mansoni neuropeptide receptor 0.0039 0.0058 0.0055
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0107 0.0221 0.0663
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0028
Brugia malayi Melatonin receptor type 1A 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis microtubule associated protein 2 0.0384 0.0886 0.2983
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0017 0.0048
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0058 0.0184
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0059 0.019
Brugia malayi ecdysone receptor 0.0101 0.0206 0.0637
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0126 0.0266 0.0825
Onchocerca volvulus 0.0039 0.0058 0.0181
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0041 0.0129
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0058 0.0189
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0055 0.1226
Echinococcus multilocularis peregrin 0.0032 0.0041 0.0129
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0214 0.0477 0.0474
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0136 0.0417
Loa Loa (eye worm) hypothetical protein 0.0214 0.0477 0.1488
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0135 0.0132
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0058 0.0171
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.2913
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.016 0.0349 0.7719
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0214 0.0477 0.0474
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0113 0.0235 0.0784
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0107 0.0221 0.0735
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0012 0.0007
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Schistosoma mansoni protein phosphatase 2C 0.0019 0.001 0.0007
Schistosoma mansoni neuropeptide receptor 0.0039 0.0058 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0101 0.0206 0.069
Echinococcus granulosus Nuclear hormone receptor HR96 0.0101 0.0206 0.069
Brugia malayi jmjC domain containing protein 0.0138 0.0296 0.0918
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0058 0.0189
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0059 0.019
Echinococcus multilocularis ecdysone induced protein 78C 0.0214 0.0477 0.1602
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.002 0.0012 0.0028
Echinococcus granulosus fmrfamide receptor 0.0039 0.0058 0.0189
Schistosoma mansoni opsin-like receptor 0.0039 0.0058 0.0055
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Brugia malayi beta-lactamase family protein 0.002 0.0012 0.0028
Loa Loa (eye worm) hypothetical protein 0.0107 0.0221 0.0683
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0112 0.0367
Schistosoma mansoni transcription factor LCR-F1 0.0027 0.0027 0.0025
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0101 0.0206 0.0682
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0214 0.0477 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0428
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0107 0.0221 0.0218
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0107 0.0221 0.0663
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Brugia malayi steroid hormone receptor 0.0214 0.0477 0.1488
Leishmania major C-8 sterol isomerase-like protein 0.1342 0.3192 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0073 0.0139 0.0849
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0107 0.0221 0.0683
Echinococcus granulosus lipoxygenase domain containing protein 0.0033 0.0042 0.0137
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0107 0.0221 0.0663
Schistosoma mansoni amine GPCR 0.0039 0.0058 0.0055
Plasmodium falciparum phd finger protein, putative 0.0032 0.0041 0.0425
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0107 0.0221 0.0663
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.001 0.0007
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus granulosus g protein coupled receptor 0.0039 0.0058 0.0189
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0107 0.0221 0.0663
Schistosoma mansoni microtubule-associated protein tau 0.0384 0.0886 0.0884
Schistosoma mansoni chromobox protein 0.0038 0.0055 0.0052
Onchocerca volvulus 0.002 0.0012 0.0026
Echinococcus granulosus nuclear receptor nhr 48 0.0101 0.0206 0.069
Loa Loa (eye worm) hypothetical protein 0.0431 0.0999 0.3125
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0683 0.1606 0.1603
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0058 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Onchocerca volvulus 0.0033 0.0042 0.0128
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0073 0.0139 0.0137
Loa Loa (eye worm) hypothetical protein 0.0113 0.0235 0.0728
Echinococcus granulosus biogenic amine 5HT receptor 0.0642 0.1508 0.5087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0058 0.0184
Onchocerca volvulus 0.0039 0.0058 0.0181
Echinococcus granulosus chromobox protein 1 0.0038 0.0055 0.0182
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0058 0.0171
Treponema pallidum sodium- and chloride- dependent transporter 0.0431 0.0999 1
Schistosoma mansoni hypothetical protein 0.0027 0.0027 0.0025
Onchocerca volvulus 0.0023 0.0018 0.0047
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0058 0.0184
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0073 0.0139 0.0466
Brugia malayi latrophilin 2 splice variant baaae 0.0086 0.017 0.0525
Brugia malayi Serotonin receptor 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0431 0.0999 0.3125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.016 0.0349 0.7719
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0019 0.0419
Plasmodium vivax amine transporter, putative 0.0073 0.0139 0.1826
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0139 0.0137
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0058 0.0189
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0012 0.0259
Onchocerca volvulus 0.0101 0.0206 0.0682
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0027 0.0027 0.0088
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0107 0.0221 0.0663
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Loa Loa (eye worm) hypothetical protein 0.0113 0.0235 0.0728
Brugia malayi Ets-domain containing protein 0.005 0.0083 0.0251
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0135 0.0132
Loa Loa (eye worm) nuclear receptor NHR-67 0.0101 0.0206 0.0637
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0012 0.0259
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0214 0.0477 0.1602
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0107 0.0221 0.4882
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0126 0.0266 0.0825
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Echinococcus granulosus neuropeptide receptor 0.0039 0.0058 0.0189
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0135 0.0413
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0128 0.0271 1
Loa Loa (eye worm) DR-78 0.0101 0.0206 0.0637
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.0233 0.023
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0058 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0214 0.0477 0.1488
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0139 0.0428
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0112 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0214 0.0477 0.1488
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.002 0.0012 0.0009
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.0266 0.0892
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0139 0.1826
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Onchocerca volvulus 0.002 0.0012 0.0026
Schistosoma mansoni jumonji domain containing protein 0.0019 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0021
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0058 0.0055
Brugia malayi ecdysteroid receptor 0.0214 0.0477 0.1488
Echinococcus multilocularis geminin 0.0336 0.0771 0.2593
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0107 0.0221 0.0218
Echinococcus granulosus lamin dm0 0.0046 0.0074 0.0246
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0122
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0014 0.03
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0135 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0112 0.0233 0.0777
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.1342 0.3192 1
Brugia malayi jmjC domain containing protein 0.0019 0.001 0.0021
Echinococcus multilocularis nuclear receptor nhr 48 0.0101 0.0206 0.0686
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0124 0.0262 0.3409
Echinococcus granulosus FTZ F1 alpha 0.0214 0.0477 0.1606
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Brugia malayi conserved hypotetical protein 0.0101 0.0206 0.0637
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0428
Schistosoma mansoni steroid hormone receptor ad4bp 0.0214 0.0477 0.0474
Echinococcus multilocularis serotonin transporter 0.0431 0.0999 0.3365
Brugia malayi Intermediate filament tail domain containing protein 0.0046 0.0074 0.0224
Onchocerca volvulus 0.0039 0.0058 0.0181
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0107 0.0221 0.0663
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0058 0.0189
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0058 0.0171
Onchocerca volvulus 0.0046 0.0074 0.0238
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0428
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0214 0.0477 0.1606
Onchocerca volvulus 0.0073 0.0139 0.0458
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Echinococcus multilocularis sex peptide receptor 0.0039 0.0058 0.0184
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0058 0.0055
Echinococcus multilocularis phd:f box containing protein 0.0019 0.001 0.0022
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0058 0.0055
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.001 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Schistosoma mansoni rab6-interacting 0.0033 0.0042 0.0039
Schistosoma mansoni opsin-like receptor 0.0039 0.0058 0.0055
Onchocerca volvulus 0.0046 0.0074 0.0238
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0112 0.0233 0.0722
Brugia malayi hypothetical protein 0.0033 0.0042 0.0122
Leishmania major hypothetical protein, conserved 0.0107 0.0221 0.0663
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0107 0.0221 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0214 0.0477 0.1488
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0684 0.1609 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0642 0.1508 0.1506
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0107 0.0221 0.0683
Loa Loa (eye worm) hypothetical protein 0.0086 0.017 0.0525
Schistosoma mansoni thyroid hormone receptor 0.0214 0.0477 0.0474
Onchocerca volvulus Alhambra homolog 0.0032 0.0041 0.0125
Schistosoma mansoni nuclear hormone receptor 0.0101 0.0206 0.0203
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0058 0.0189
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.075 0.4533
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0221 0.4882
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0058 0.0189
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0022 0.0017 0.0044
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.2849
Schistosoma mansoni thyroid hormone receptor 0.0214 0.0477 0.0474
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi Bromodomain containing protein 0.0032 0.0041 0.0119
Echinococcus multilocularis somatostatin receptor 0.0039 0.0058 0.0184
Brugia malayi GnHR receptor homolog 0.0039 0.0058 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0058 0.0184
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Schistosoma mansoni sodium/chloride dependent transporter 0.0074 0.0141 0.0138
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.0663
Brugia malayi neuropeptide F receptor 0.0039 0.0058 0.0171
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0107 0.0221 0.0218
Echinococcus granulosus sodium and chloride dependent glycine 0.0073 0.0139 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0214 0.0477 0.1488
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0058 0.0189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0214 0.0477 0.1488
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0112 0.2468
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0014 0.03
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.016 0.0349 0.7719
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0012 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0113 0.0235 0.0728
Plasmodium falciparum LCCL domain-containing protein 0.0033 0.0042 0.0437
Brugia malayi hypothetical protein 0.0073 0.0139 0.0428
Trichomonas vaginalis esterase, putative 0.002 0.0012 0.0259
Brugia malayi Dopamine receptor protein 2 0.0039 0.0058 0.0171
Echinococcus granulosus sodium and chloride dependent glycine 0.0073 0.0139 0.0466
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0214 0.0477 0.1488
Schistosoma mansoni nuclear receptor nhr-48 0.0101 0.0206 0.0203
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.0642 0.1508 0.4721
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0327 0.075 1
Echinococcus multilocularis lamin dm0 0.0046 0.0074 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0112 0.2468
Onchocerca volvulus 0.0073 0.0139 0.0458
Loa Loa (eye worm) beta-lactamase 0.002 0.0012 0.0028
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0107 0.0221 0.2849
Onchocerca volvulus 0.0039 0.0058 0.0181
Brugia malayi nuclear receptor NHR-67 0.0101 0.0206 0.0637
Echinococcus granulosus vesicular acetylcholine transporter 0.1248 0.2964 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0214 0.0477 0.1599
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0059 0.0177
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0058 0.0171
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.2849
Brugia malayi Ets-domain containing protein 0.005 0.0083 0.0251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0126 0.0266 0.0825
Schistosoma mansoni adenoreceptor 0.0039 0.0058 0.0055
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0135 0.0445
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.005 0.0083 0.0251
Echinococcus granulosus thyroid hormone receptor alpha 0.0101 0.0206 0.069
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0431 0.0999 0.0997
Echinococcus multilocularis lipoxygenase domain containing protein 0.0033 0.0042 0.0132
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0023 0.0019 0.0051
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0058 0.0184
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0073 0.0139 0.0461
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0022 0.0017 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0038
Echinococcus granulosus ecdysone induced protein 78C 0.0214 0.0477 0.1606
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Toxoplasma gondii hypothetical protein 0.0073 0.0139 0.0849
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0058 0.0189
Schistosoma mansoni myosin xvIII 0.0039 0.0058 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.016 0.0349 0.7719
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0576 0.1349 0.4221
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0058 0.0055
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0107 0.0221 0.0663
Plasmodium vivax JmjC domain containing protein 0.0019 0.001 0.0088
Schistosoma mansoni histamine h1 receptor 0.0039 0.0058 0.0055
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0021
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0071 0.0231
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0214 0.0477 0.0474
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0107 0.0221 0.0218
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0107 0.0221 0.074
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0107 0.0221 0.0683
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.016 0.0349 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0041 0.0119
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1248 0.2964 0.9286
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi G-protein coupled receptor 0.0039 0.0058 0.0171
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0058 0.0055
Schistosoma mansoni sodium-dependent amino acid transporter 0.0073 0.0139 0.0137
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0058 0.0055
Schistosoma mansoni biogenic amine receptor 0.0039 0.0058 0.0055
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.0064 0.0117 0.0359
Brugia malayi chromobox protein homolog 3 0.0021 0.0015 0.0038
Echinococcus granulosus sex peptide receptor 0.0039 0.0058 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.002 0.0012 0.0259
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0107 0.0221 0.0218
Loa Loa (eye worm) hypothetical protein 0.1103 0.2615 0.8191
Schistosoma mansoni retinoic acid receptor RXR 0.0214 0.0477 0.0474
Schistosoma mansoni intermediate filament proteins 0.0046 0.0074 0.0071
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0058 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0203 0.0452 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0124 0.0262 0.1413
Toxoplasma gondii preprocathepsin c precursor, putative 0.0327 0.075 0.4653
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0078 0.0152 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0431 0.0999 0.0997
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Schistosoma mansoni amine GPCR 0.0039 0.0058 0.0055
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0039 0.0058 0.0181
Giardia lamblia Encystation-specific protease 0.0124 0.0262 0.1413
Schistosoma mansoni nuclear hormone receptor 0.0214 0.0477 0.0474
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0073 0.0139 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0058 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0058 0.0184
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0058 0.0171
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0058 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0214 0.0477 0.1488
Echinococcus granulosus tar DNA binding protein 0.0071 0.0135 0.045
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0107 0.0221 0.074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0058 0.0184
Echinococcus granulosus lipoxygenase domain containing protein 0.0033 0.0042 0.0137
Loa Loa (eye worm) hypothetical protein 0.0683 0.1606 0.5027
Schistosoma mansoni nuclear hormone receptor 0.0101 0.0206 0.0203
Schistosoma mansoni gabp alpha 0.005 0.0083 0.008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0136 0.0133
Schistosoma mansoni hypothetical protein 0.0032 0.0041 0.0038
Echinococcus granulosus g protein coupled receptor 0.0039 0.0058 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0108 0.0224 0.1377
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0059 0.0195
Brugia malayi vesicular acetylcholine transporter unc-17 0.1248 0.2964 0.9286
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.0663
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0224
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0576 0.1349 0.4548
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0428
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0221 0.0663
Echinococcus multilocularis vesicular acetylcholine transporter 0.1248 0.2964 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0112 0.0321
Schistosoma mansoni lipoxygenase 0.0126 0.0266 0.0263
Echinococcus granulosus GPCR family 2 0.004 0.0059 0.0195
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0107 0.0221 0.0663
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0073 0.0139 0.0466
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0139 0.0137
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Echinococcus granulosus serotonin transporter 0.0431 0.0999 0.3368
Echinococcus granulosus geminin 0.0336 0.0771 0.2596
Schistosoma mansoni vesicular acetylcholine transporter 0.1248 0.2964 0.2962
Loa Loa (eye worm) nuclear hormone receptor 0.0101 0.0206 0.0637
Echinococcus multilocularis lamin 0.0046 0.0074 0.0241
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0058 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0221 0.4882
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0058 0.0171
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0073 0.0139 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0058 0.0184
Schistosoma mansoni hypothetical protein 0.0039 0.0058 0.0055
Schistosoma mansoni biogenic amine receptor 0.0039 0.0058 0.0055
Loa Loa (eye worm) RNA binding protein 0.0071 0.0135 0.0413
Brugia malayi putative neuropeptide receptor 0.0039 0.0058 0.0171
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0073 0.0139 0.0428
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0221 0.0663
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0012 0.0259
Leishmania major hypothetical protein, conserved 0.0107 0.0221 0.0663
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0058 0.0189
Trypanosoma brucei C-8 sterol isomerase, putative 0.1342 0.3192 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0214 0.0477 0.1488
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0058 0.0189
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0058 0.0184
Brugia malayi Nuclear hormone receptor E75 0.0101 0.0206 0.0637
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0221 0.0663
Onchocerca volvulus 0.0039 0.0058 0.0181
Plasmodium falciparum phosphodiesterase delta, putative 0.0107 0.0221 0.2849
Onchocerca volvulus 0.0039 0.0058 0.0181
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0058 0.0189
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0107 0.0221 0.074
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.001 0.0027
Schistosoma mansoni hypothetical protein 0.0039 0.0058 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0113 0.0235 0.0232
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.001 0.0021
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0107 0.0221 0.0218
Echinococcus multilocularis beta LACTamase domain containing family member 0.002 0.0012 0.003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0214 0.0477 0.1488
Echinococcus granulosus Nuclear hormone receptor HR96 0.0101 0.0206 0.069
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0101 0.0206 0.0686
Brugia malayi nuclear receptor RXR 0.0101 0.0206 0.0637
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.002 0.0012 0.0009
Brugia malayi beta-lactamase 0.002 0.0012 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Onchocerca volvulus 0.002 0.0012 0.0026
Loa Loa (eye worm) heterochromatin protein 1 0.0038 0.0055 0.0165
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus granulosus allatostatin A receptor 0.0039 0.0058 0.0189
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Brugia malayi Heterochromatin protein 1 0.0038 0.0055 0.0165
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0073 0.0139 0.0137
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0113 0.0235 0.0232
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.016 0.0349 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Brugia malayi sulfakinin receptor protein 0.0039 0.0058 0.0171
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.001 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0107 0.0221 0.0735
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0113 0.0235 0.0728
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0112 0.0233 0.0782
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0041 0.0237
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.0023 0.0063
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0214 0.0477 0.1602
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0058 0.0184
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Onchocerca volvulus 0.0039 0.0058 0.0181
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Schistosoma mansoni hypothetical protein 0.004 0.0059 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0214 0.0477 0.1488
Schistosoma mansoni hypothetical protein 0.004 0.0059 0.0056
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0073 0.0139 0.0466
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0101 0.0206 0.0682
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Giardia lamblia Fructose-bisphosphate aldolase 0.016 0.0349 0.1967
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.001 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0016 0.0003 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0214 0.0477 0.1602
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0214 0.0477 0.1606
Schistosoma mansoni jumonji domain containing protein 0.0116 0.0244 0.0241
Onchocerca volvulus 0.0039 0.0058 0.0181
Onchocerca volvulus 0.0039 0.0058 0.0181
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0058 0.0184
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0214 0.0477 0.1599
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0113 0.0235 0.0788
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0214 0.0477 0.1488
Loa Loa (eye worm) hypothetical protein 0.0214 0.0477 0.1488
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0136 0.0449
Brugia malayi RE15519p 0.0039 0.0058 0.0171
Onchocerca volvulus 0.0039 0.0058 0.0181
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0327 0.075 1
Onchocerca volvulus 0.0101 0.0206 0.0682
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0107 0.0221 0.0218
Loa Loa (eye worm) hypothetical protein 0.0214 0.0477 0.1488
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0058 0.0171
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0058 0.0189
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0055 0.1226
Loa Loa (eye worm) hypothetical protein 0.0642 0.1508 0.4721
Loa Loa (eye worm) hypothetical protein 0.0214 0.0477 0.1488
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0078 0.0152 0.5397
Onchocerca volvulus 0.013 0.0276 0.0918
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0136 0.0454
Brugia malayi follicle stimulating hormone receptor 0.0293 0.0668 0.2087
Brugia malayi Dopamine receptor 0.0039 0.0058 0.0171
Plasmodium vivax multidomain scavenger receptor, putative 0.0033 0.0042 0.0522
Echinococcus multilocularis Polycystic kidney disease protein 0.0033 0.0042 0.0132
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Loa Loa (eye worm) hypothetical protein 0.0214 0.0477 0.1488
Loa Loa (eye worm) hypothetical protein 0.0431 0.0999 0.3125
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0214 0.0477 0.1606
Echinococcus granulosus intermediate filament protein 0.0046 0.0074 0.0246
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0122
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0058 0.0184
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0058 0.0189
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0058 0.0171
Brugia malayi nuclear hormone receptor family member odr-7 0.0101 0.0206 0.0637
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0022 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0058 0.0055
Schistosoma mansoni RAR-like nuclear receptor 0.0214 0.0477 0.0474
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0214 0.0477 0.1488
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0041 0.0038
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Onchocerca volvulus Neuropeptide F receptor homolog 0.0039 0.0058 0.0181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0214 0.0477 0.1602
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0071 0.0236
Echinococcus multilocularis musashi 0.0046 0.0074 0.0241
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0073 0.0139 0.0428
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0107 0.0221 0.0663
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0058 0.0189
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1342 0.3192 1
Brugia malayi RNA binding protein 0.0071 0.0135 0.0413
Schistosoma mansoni hypothetical protein 0.0086 0.017 0.0167
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0135 0.0413
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0114 0.0238 0.0737
Echinococcus multilocularis GA binding protein alpha chain 0.005 0.0083 0.0271
Trypanosoma brucei protein kinase, putative 0.0062 0.0112 0.0321
Trichomonas vaginalis penicillin-binding protein, putative 0.002 0.0012 0.0259
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0214 0.0477 0.1488
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0101 0.0206 0.069
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0221 0.0663
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.001 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0101 0.0206 0.0686
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0058 0.0189
Onchocerca volvulus 0.0039 0.0058 0.0181
Brugia malayi nuclear hormone receptor family member nhr-6 0.0101 0.0206 0.0637
Brugia malayi nuclear hormone receptor 0.0214 0.0477 0.1488
Brugia malayi orphan nuclear receptor NR2E1 0.0101 0.0206 0.0637
Plasmodium falciparum transporter, putative 0.0073 0.0139 0.1753
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0112 0.0321
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0058 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0058 0.0184
Echinococcus multilocularis chromobox protein 1 0.0038 0.0055 0.0177
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0058 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0012 0.0007
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0058 0.0055
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0041 0.0237
Brugia malayi hypothetical protein 0.0113 0.0235 0.0728
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0107 0.0221 0.0663
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.0233 0.023
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0124 0.0262 0.1413
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.001 0.0022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0058 0.0055
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0058 0.0184
Plasmodium falciparum amino acid transporter, putative 0.0073 0.0139 0.1753
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0073 0.0139 0.0461
Schistosoma mansoni polycystin 1-related 0.0033 0.0042 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0214 0.0477 0.0474
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0073 0.0139 0.0137
Brugia malayi hypothetical protein 0.0113 0.0235 0.0728
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0107 0.0221 0.0735
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0112 0.0341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.016 0.0349 0.7719
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0101 0.0206 0.0686
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0059 0.0195
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Brugia malayi Pre-SET motif family protein 0.0114 0.0238 0.0737
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0058 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0015 0.0333
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0107 0.0221 0.4882
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0327 0.075 0.0748
Brugia malayi G protein-coupled receptor 0.0039 0.0058 0.0171
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0058 0.0184
Brugia malayi hypothetical protein 0.0039 0.0058 0.0171
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0101 0.0206 0.0686
Brugia malayi tailless protein 0.0101 0.0206 0.0637
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0683 0.1606 0.5416
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0683 0.1606 0.5416
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0112 0.2468
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.016 0.0349 0.7719
Brugia malayi hypothetical protein 0.0027 0.0027 0.0077
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0214 0.0477 0.1488
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0112 0.0233 0.0777
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0637
Schistosoma mansoni hypothetical protein 0.0336 0.0771 0.0768
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0214 0.0477 0.1606
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0107 0.0221 0.1355
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0221 0.4882
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0078 0.0152 1
Brugia malayi jmjC domain containing protein 0.0072 0.0136 0.0417
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0327 0.075 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0112 0.0233 0.0722
Brugia malayi larval opioid receptor 0.0039 0.0058 0.0171
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0214 0.0477 0.1606
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0058 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0028
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0112 0.0321
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi MAP kinase sur-1 0.0062 0.0112 0.0341
Brugia malayi AKH receptor 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0003
Echinococcus multilocularis serotonin receptor 0.0642 0.1508 0.5084
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0058 0.0184
Echinococcus granulosus orexin receptor type 2 0.0039 0.0058 0.0189
Brugia malayi Serotonin receptor 0.0039 0.0058 0.0171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0058 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0058 0.0189
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0058 0.0189
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0107 0.0221 0.0735
Onchocerca volvulus 0.0073 0.0139 0.0458
Brugia malayi PHD-finger family protein 0.0032 0.0041 0.0119
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0046 0.0074 0.0224
Brugia malayi Nuclear hormone receptor E75 0.0101 0.0206 0.0637
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0221 0.4882
Trichomonas vaginalis set domain proteins, putative 0.013 0.0276 0.6103
Echinococcus granulosus microtubule associated protein 2 0.0384 0.0886 0.2987
Brugia malayi nuclear receptor NHR-88 0.0214 0.0477 0.1488
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0576 0.1349 0.4221
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0058 0.0189
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0058 0.0189
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0107 0.0221 0.0683
Loa Loa (eye worm) hypothetical protein 0.0113 0.0235 0.0728
Echinococcus multilocularis sodium and chloride dependent glycine 0.0073 0.0139 0.0461
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0171
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0058 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0112 0.0109
Brugia malayi Nuclear hormone receptor-like 1 0.0214 0.0477 0.1488
Giardia lamblia Hypothetical protein 0.0107 0.0221 0.1148
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0135 0.0413
Brugia malayi nuclear receptor NHR-88 0.0101 0.0206 0.0637
Echinococcus multilocularis chromobox protein 1 0.0038 0.0055 0.0177
Schistosoma mansoni lamin 0.0046 0.0074 0.0071
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0124 0.0262 0.3468
Loa Loa (eye worm) serotonin transporter b 0.0431 0.0999 0.3125
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0073 0.0139 0.0137
Onchocerca volvulus 0.0039 0.0058 0.0181
Echinococcus granulosus somatostatin receptor 0.0039 0.0058 0.0189
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1103 0.2615 0.8191
Onchocerca volvulus Bile acid receptor homolog 0.0214 0.0477 0.1599
Brugia malayi intermediate filament protein 0.0046 0.0074 0.0224
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0112 0.0321
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0058 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0214 0.0477 0.1488

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 25.94 nM BindingDB_Patents: IMAP-FP Assay. Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was determined from a 10 point (1:3 serial dilution, 3 uM starting compound concentration) titration curve using the following outlined procedure. To each well of a black Corning 384-well plate (Corning Catalog #3575), 7.5 mL of compound (3333 fold dilution in final assay volume of 25 uL) was dispensed, followed by the addition of 15 uL of kinase buffer (tween containing kinase buffer, Molecular Devices) containing 0.0364 ng/mL (0.833 nM) of phosphorylated active hERK2 enzyme. Following a 15 minute compound & enzyme incubation, each reaction was initiated by the addition of 10 uL kinase buffer containing 2.45 uM ERK2 IMAP substrate peptides (2.25 uM-unlabeled IPTTPITTTYFFFK-COOH and 200 nM-labeled IPTTPITTTYFFFK-5FAM (5-carboxyfluorescein)-COOH), and 75 uM ATP. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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