Detailed information for compound 203041

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.237 | Formula: C11H14F2N2O4
  • H donors: 3 H acceptors: 3 LogP: -0.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(CC1O)(C)n1cc(F)c(c(c1=O)F)N
  • InChi: 1S/C11H14F2N2O4/c1-11(2-6(17)7(4-16)19-11)15-3-5(12)9(14)8(13)10(15)18/h3,6-7,16-17H,2,4,14H2,1H3
  • InChiKey: QAVBZUWYDJQFBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0017
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0039 0.0065
Brugia malayi Cytochrome P450 family protein 0.0021 0.0039 0.0059
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0089 0.0382 0.0382
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0046 0.0046
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1681 0.8339 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0297 0.0743
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Echinococcus granulosus mitogen activated protein kinase 0.0063 0.0252 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0803 0.2392
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Onchocerca volvulus 0.003 0.0087 0.0542
Loa Loa (eye worm) hypothetical protein 0.0089 0.0382 0.0451
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0179 0.083 0.083
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.0578 0.0578
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0063 0.0252 0.0714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.014 0.0636 0.0756
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0017 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Trypanosoma cruzi aminopeptidase, putative 0.0089 0.0382 0.111
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0017 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.024 0.1134 0.2955
Mycobacterium leprae putative cytochrome p450 0.0021 0.0039 0.5
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0089 0.0382 0.111
Echinococcus multilocularis lamin dm0 0.003 0.0087 0.0087
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0382 0.0966
Schistosoma mansoni intermediate filament proteins 0.003 0.0087 0.0087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0156 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0248 0.0701
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Entamoeba histolytica hypothetical protein 0.0035 0.0111 0.0287
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0039
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0089 0.0382 0.111
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0615 0.3009 0.9107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0115 0.0115
Brugia malayi hypothetical protein 0.0035 0.0111 0.0251
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0071 0.0071
Mycobacterium ulcerans aminopeptidase N PepN 0.0089 0.0382 0.6368
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Echinococcus granulosus intermediate filament protein 0.003 0.0087 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0115 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0156 0.0156
Leishmania major hypothetical protein, conserved 0.0029 0.0079 0.0189
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Brugia malayi serine/threonine kinase 12 0.0615 0.3009 0.7911
Loa Loa (eye worm) AUR protein kinase 0.0615 0.3009 0.3604
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0673 0.3302 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0297 0.035
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0673 0.3302 1
Echinococcus granulosus tar DNA binding protein 0.0072 0.0297 0.0297
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0252 0.0714
Leishmania major cathepsin L-like protease 0.0062 0.0248 0.0701
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Giardia lamblia Aurora kinase 0.0615 0.3009 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0115 0.0115
Loa Loa (eye worm) AUR protein kinase 0.0615 0.3009 0.3604
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0039 0.0065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0084 0.0354 0.0418
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0181 0.0498
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.0578 0.0578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0115 0.0115
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0673 0.3302 0.3956
Echinococcus granulosus lamin dm0 0.003 0.0087 0.0087
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0046 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0615 0.3009 0.9107
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.0252 0.0714
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0089 0.0382 0.1052
Entamoeba histolytica protein kinase, putative 0.0615 0.3009 0.9107
Loa Loa (eye worm) RNA binding protein 0.0072 0.0297 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0673 0.3302 0.3956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0089
Echinococcus multilocularis mitogen activated protein kinase 0.0063 0.0252 0.0252
Echinococcus multilocularis geminin 0.0363 0.1748 0.1748
Brugia malayi hypothetical protein 0.0089 0.0382 0.0966
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Brugia malayi CXXC zinc finger family protein 0.0084 0.0354 0.0893
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0039 0.0065
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0615 0.3009 0.9107
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0087 0.0186
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0673 0.3302 0.8686
Loa Loa (eye worm) cysteine protease 0.0016 0.0017 0.0014
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0673 0.3302 1
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0252 0.0714
Loa Loa (eye worm) hypothetical protein 0.014 0.0636 0.0756
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0089 0.0382 0.111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0673 0.3302 0.3302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0156 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0131
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0248 0.0701
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.0017
Brugia malayi Cytochrome P450 family protein 0.0021 0.0039 0.0059
Toxoplasma gondii aurora kinase 0.0615 0.3009 0.9107
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0297 0.0297
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.0578 0.0578
Trypanosoma brucei protein kinase, putative 0.0063 0.0252 0.0653
Brugia malayi serine/threonine protein kinase 6 0.0615 0.3009 0.7911
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0111 0.0111
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.0578 0.1705
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0046 0.0046
Schistosoma mansoni lamin 0.003 0.0087 0.0087
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0382 0.111
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0089 0.0382 0.0382
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0017 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0252 0.0714
Brugia malayi TATA binding protein associated factor 0.0089 0.0382 0.0966
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0046 0.0046
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0673 0.3302 1
Loa Loa (eye worm) intermediate filament protein 0.003 0.0087 0.0097
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.119 0.1422
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0115 0.0115
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0115 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Schistosoma mansoni aminopeptidase A (M01 family) 0.0089 0.0382 0.0382
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1681 0.8339 0.8339
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0071 0.0071
Onchocerca volvulus 0.0084 0.0354 0.2629
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0079 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Echinococcus granulosus leukotriene A 4 hydrolase 0.1681 0.8339 0.8339
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.119 0.3103
Echinococcus multilocularis mitogen activated protein kinase 3 0.0063 0.0252 0.0252
Brugia malayi Cytochrome P450 family protein 0.0021 0.0039 0.0059
Schistosoma mansoni hypothetical protein 0.0021 0.0039 0.0039
Trypanosoma brucei Aminopeptidase M1, putative 0.0089 0.0382 0.1052
Schistosoma mansoni protein kinase 0.0615 0.3009 0.3009
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0673 0.3302 1
Brugia malayi intermediate filament protein 0.003 0.0087 0.0186
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0578 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0115 0.0261
Brugia malayi hypothetical protein 0.0029 0.0079 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Loa Loa (eye worm) cytochrome P450 family protein 0.0095 0.041 0.0485
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0039 0.004
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0673 0.3302 0.3302
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Echinococcus multilocularis aminopeptidase N 0.0089 0.0382 0.0382
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Brugia malayi RNA binding protein 0.0072 0.0297 0.0743
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0673 0.3302 1
Onchocerca volvulus 0.0089 0.0382 0.2845
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.0252 0.0714
Echinococcus multilocularis dnaJ subfamily B 0.1193 0.5901 0.5901
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0039 0.004
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0297 0.0297
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0063 0.0252 0.0714
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0017 0.0014
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0382 0.0966
Leishmania major cytochrome p450-like protein 0.0021 0.0039 0.0065
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0039 0.5
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0673 0.3302 0.8686
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0252 0.0252
Leishmania major cathepsin L-like protease 0.0062 0.0248 0.0701
Schistosoma mansoni microtubule-associated protein tau 0.2013 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0039 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0615 0.3009 0.3009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0156 0.0156
Loa Loa (eye worm) AUR protein kinase 0.0615 0.3009 0.3604
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0087 0.0097
Entamoeba histolytica aminopeptidase, putative 0.0089 0.0382 0.111
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0039 0.0065
Entamoeba histolytica hypothetical protein 0.0035 0.0111 0.0287
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0089 0.0382 0.0382
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0016 0.0013
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0008 0.0008
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0079 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Echinococcus multilocularis 0.0021 0.0039 0.0039
Entamoeba histolytica hypothetical protein 0.0035 0.0111 0.0287
Leishmania major cathepsin L-like protease 0.0062 0.0248 0.0701
Loa Loa (eye worm) hypothetical protein 0.0089 0.0382 0.0451
Echinococcus granulosus aurora kinase A 0.0615 0.3009 0.3009
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Trypanosoma brucei aminopeptidase, putative 0.0089 0.0382 0.1052
Trypanosoma brucei Aminopeptidase M1, putative 0.0089 0.0382 0.1052
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0156 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Onchocerca volvulus Huntingtin homolog 0.014 0.0636 0.4826
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0089 0.0382 0.111
Onchocerca volvulus 0.0089 0.0382 0.2845
Brugia malayi serine/threonine-protein kinase 6 0.0615 0.3009 0.7911
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0017
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.007 0.014
Schistosoma mansoni cytochrome P450 0.0021 0.0039 0.0039
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0673 0.3302 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.01 0.01
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0673 0.3302 1
Schistosoma mansoni hypothetical protein 0.1193 0.5901 0.5901
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0382 0.111
Trichomonas vaginalis AGC family protein kinase 0.0615 0.3009 0.9107
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0673 0.3302 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Schistosoma mansoni cpg binding protein 0.0089 0.0378 0.0378
Toxoplasma gondii aminopeptidase n, putative 0.0089 0.0382 0.111
Loa Loa (eye worm) aminopeptidase N 0.0089 0.0382 0.0451
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0063 0.0252 0.0295
Brugia malayi hypothetical protein 0.0019 0.0028 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0248 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0014
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0615 0.3009 0.9107
Onchocerca volvulus Huntingtin homolog 0.014 0.0636 0.4826
Trichomonas vaginalis helicase, putative 0.0019 0.003 0.0039
Trypanosoma cruzi aurora B kinase, putative 0.0615 0.3009 0.9107
Echinococcus granulosus dnaJ subfamily B 0.1193 0.5901 0.5901
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.0017
Onchocerca volvulus 0.0089 0.0382 0.2845
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0382 0.111
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0079 0.0189
Loa Loa (eye worm) ctsf protein 0.0016 0.0017 0.0014
Leishmania major cytochrome p450-like protein 0.0021 0.0039 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0578 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Loa Loa (eye worm) TATA binding protein associated factor 0.0089 0.0382 0.0451
Onchocerca volvulus 0.0036 0.0115 0.0764
Brugia malayi MAP kinase sur-1 0.0063 0.0252 0.0622
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0039 0.0065
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0063 0.0252 0.0714
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0221 0.0619
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0089 0.0382 0.111
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0039 0.0065
Brugia malayi cytochrome P450 0.0021 0.0039 0.0059
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0673 0.3302 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Onchocerca volvulus 0.0273 0.1299 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0382 0.111
Toxoplasma gondii aminopeptidase N protein 0.0089 0.0382 0.111
Entamoeba histolytica protein kinase , putative 0.0615 0.3009 0.9107
Echinococcus granulosus geminin 0.0363 0.1748 0.1748
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0063 0.0252 0.0653
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0089 0.0382 0.111
Echinococcus granulosus lamin 0.003 0.0087 0.0087
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0615 0.3009 0.3009
Schistosoma mansoni hypothetical protein 0.0363 0.1748 0.1748
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0089 0.0382 0.111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Plasmodium falciparum serine/threonine protein kinase, putative 0.0615 0.3009 0.9107
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0759 0.5787
Mycobacterium ulcerans aminopeptidase N PepN 0.0089 0.0382 0.6368
Echinococcus granulosus cpg binding protein 0.0089 0.0378 0.0378
Leishmania major cytochrome p450-like protein 0.0021 0.0039 0.0065
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0673 0.3302 0.3302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0115 0.0115
Trypanosoma cruzi Aminopeptidase M1, putative 0.0089 0.0382 0.111
Brugia malayi hypothetical protein 0.0773 0.3799 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.0017
Loa Loa (eye worm) cytochrome P450 0.0021 0.0039 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0039
Leishmania major protein kinase, putative 0.0615 0.3009 0.9107
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0248 0.0701
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0615 0.3009 0.9107
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0615 0.3009 0.3009
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0071 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0759 0.2257
Trypanosoma cruzi aminopeptidase, putative 0.0089 0.0382 0.111
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0252 0.0714
Schistosoma mansoni hypothetical protein 0.0035 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Echinococcus multilocularis musashi 0.003 0.0087 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0248 0.0641
Toxoplasma gondii histone lysine methyltransferase SET1 0.016 0.0735 0.2186
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0156 0.037
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.0017
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0063 0.0252 0.0714
Entamoeba histolytica hypothetical protein 0.0035 0.0111 0.0287
Trichomonas vaginalis AGC family protein kinase 0.0615 0.3009 0.9107
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.1134 0.1354
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0156 0.0156
Trypanosoma brucei aurora B kinase 0.0615 0.3009 0.9102
Echinococcus granulosus aminopeptidase N 0.0089 0.0382 0.0382
Brugia malayi Peptidase family M1 containing protein 0.0089 0.0382 0.0966
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1681 0.8339 0.8339
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0111 0.0111
Echinococcus granulosus cathepsin l1 0.0016 0.0017 0.0017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.0578 0.1705
Schistosoma mansoni cpg binding protein 0.0084 0.0354 0.0354
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0111 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.119 0.3571
Trichomonas vaginalis AGC family protein kinase 0.0615 0.3009 0.9107
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0079 0.0189
Brugia malayi TAR-binding protein 0.0072 0.0297 0.0743
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0578 1
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.0578 0.0578
Toxoplasma gondii aminopeptidase N, putative 0.0089 0.0382 0.111
Trichomonas vaginalis set domain proteins, putative 0.0273 0.1299 0.3901
Loa Loa (eye worm) hypothetical protein 0.0089 0.0382 0.0451
Onchocerca volvulus 0.003 0.0087 0.0542
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0089 0.0382 0.111
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0079 0.0189
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0297 0.035
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0094
Brugia malayi Cytochrome P450 family protein 0.0095 0.041 0.104
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0046 0.0046
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0002
Entamoeba histolytica protein kinase domain containing protein 0.0615 0.3009 0.9107
Entamoeba histolytica protein kinase, putative 0.0615 0.3009 0.9107
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0089 0.0382 0.111
Echinococcus multilocularis cpg binding protein 0.0089 0.0378 0.0378
Echinococcus multilocularis microtubule associated protein 2 0.2013 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.0017
Loa Loa (eye worm) fibroinase 0.0016 0.0017 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0079 0.0189
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0079 0.0125
Echinococcus multilocularis aurora kinase A 0.0615 0.3009 0.3009
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0008 0.0008
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0063 0.0252 0.0714
Brugia malayi hypothetical protein 0.0089 0.0382 0.0966
Schistosoma mansoni hypothetical protein 0.0363 0.1748 0.1748
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0382 0.111
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.003 0.0087 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0156 0.0156
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1571 0.7793 0.7793
Loa Loa (eye worm) peptidase family M1 containing protein 0.0089 0.0382 0.0451
Echinococcus granulosus mitogen activated protein kinase 3 0.0063 0.0252 0.0252
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0089 0.0382 0.0382
Echinococcus multilocularis lamin 0.003 0.0087 0.0087
Brugia malayi hypothetical protein 0.014 0.0636 0.1637
Schistosoma mansoni lamin 0.003 0.0087 0.0087
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0115 0.0298
Schistosoma mansoni cpg binding protein 0.0089 0.0378 0.0378
Plasmodium vivax SET domain protein, putative 0.0036 0.0115 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0156 0.0156
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0039 0.0065
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0039 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.003 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0803 0.2392
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0089 0.0382 0.111
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0089 0.0382 0.111
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.0578 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0089 0.0382 0.0382

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) > 1 M Compound was tested for its inhibitory activity against L1210 lymphoid leukemia cells at 10 ug/mL ChEMBL. 3806615
T/C (functional) < 125 % Compound was tested for mean survival time of treated mice in days / mean survival time of control mice x 100 against L1210 lymphoid leukemia cells ChEMBL. 3806615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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