Detailed information for compound 2069313

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.404 | Formula: C19H22N4O2
  • H donors: 0 H acceptors: 2 LogP: 2.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CN(CCOc2ccc3c(c2)cccc3)CC(O1)Cn1cncn1
  • InChi: 1S/C19H22N4O2/c1-2-4-17-11-18(6-5-16(17)3-1)24-9-7-22-8-10-25-19(12-22)13-23-15-20-14-21-23/h1-6,11,14-15,19H,7-10,12-13H2
  • InChiKey: FDCZHZHYOIISRA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lipoxygenase 0.0142 0.0715 0.0818
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus multilocularis fibropellin Ia 0.0132 0.0656 0.0839
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.007 0.0089
Schistosoma mansoni hypothetical protein 0.0204 0.1083 0.1248
Schistosoma mansoni peroxidasin 0.105 0.6106 0.71
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0085 0.0374 0.2761
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0089
Onchocerca volvulus 0.0049 0.0165 0.025
Schistosoma mansoni septate junction protein 0.0132 0.0656 0.075
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Loa Loa (eye worm) follicle stimulating hormone receptor 0.029 0.1595 0.2026
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Mycobacterium ulcerans integral membrane transporter 0.0039 0.0104 0.0094
Schistosoma mansoni hypothetical protein 0.0132 0.0656 0.075
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.007 0.0095
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0049 0.0165 0.0199
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0049 0.0165 0.0178
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0049 0.0165 0.0199
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0049 0.0165 0.0178
Echinococcus multilocularis protein jagged 1 0.0132 0.0656 0.0839
Schistosoma mansoni sodium-dependent amino acid transporter 0.0049 0.0165 0.0178
Onchocerca volvulus 0.0246 0.1332 0.2165
Schistosoma mansoni coup transcription factor 0.0033 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus granulosus carbonic anhydrase 0.0636 0.3647 0.4737
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Brugia malayi Peroxidasin 0.105 0.6106 0.7946
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0049 0.0165 0.0214
Schistosoma mansoni notch 0.0132 0.0656 0.075
Entamoeba histolytica acetyltransferase, putative 0.0085 0.0374 0.0254
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Brugia malayi nuclear receptor NHR-88 0.0033 0.007 0.0091
Mycobacterium ulcerans transferase 0.0081 0.0355 0.0345
Onchocerca volvulus Peroxidase homolog 0.105 0.6106 1
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.007 0.0075
Echinococcus multilocularis protein jagged 1 0.0132 0.0656 0.0839
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0771 0.099
Schistosoma mansoni hypothetical protein 0.0132 0.0656 0.075
Loa Loa (eye worm) hypothetical protein 0.0291 0.16 0.2032
Onchocerca volvulus Neurogenic locus notch homolog 0.0132 0.0657 0.1057
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.007 0.0067
Echinococcus multilocularis notch 0.0132 0.0656 0.0839
Echinococcus multilocularis neurogenic locus protein delta 0.0132 0.0656 0.0839
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0054 0.0193 0.0297
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0049 0.0165 0.0178
Onchocerca volvulus Putative sulfate transporter 0.0246 0.1332 0.2165
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.007 0.0075
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus granulosus delta-like protein 1 0.0132 0.0656 0.0839
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.007 0.0067
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0048 0.0159 0.0171
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.007 0.0075
Echinococcus granulosus protein jagged 1 0.0132 0.0656 0.0839
Brugia malayi Cadherin domain containing protein 0.0132 0.0656 0.0853
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.007 0.0091
Echinococcus multilocularis geminin 0.0204 0.1083 0.1396
Schistosoma mansoni notch 0.0132 0.0656 0.075
Brugia malayi Animal haem peroxidase family protein 0.105 0.6106 0.7946
Brugia malayi hypothetical protein 0.0024 0.0012 0.0016
Treponema pallidum sodium- and chloride- dependent transporter 0.0291 0.16 0.5
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0049 0.0165 0.0172
Echinococcus multilocularis neurogenic locus notch protein 4 0.0132 0.0656 0.0839
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0085 0.0374 0.0322
Loa Loa (eye worm) hypothetical protein 0.0048 0.0159 0.0202
Leishmania major carbonic anhydrase-like protein 0.1316 0.7684 0.8939
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0049 0.0165 0.0172
Schistosoma mansoni laminin gamma-3 chain 0.0132 0.0656 0.075
Toxoplasma gondii hypothetical protein 0.0636 0.3647 1
Schistosoma mansoni carbonic anhydrase-related 0.0636 0.3647 0.4235
Echinococcus multilocularis voltage dependent calcium channel 0.0048 0.0159 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.007 0.0091
Echinococcus multilocularis carbonic anhydrase 0.0636 0.3647 0.4737
Brugia malayi EGF-like domain containing protein 0.0132 0.0656 0.0853
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0771 0.099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.007 0.0091
Schistosoma mansoni cytochrome-c oxidase 0.0054 0.0193 0.0211
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0054 0.0193 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.007 0.0089
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.007 0.0095
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0935 0.5423 0.7893
Schistosoma mansoni nuclear hormone receptor 0.0033 0.007 0.0067
Plasmodium falciparum transporter, putative 0.0049 0.0165 0.042
Loa Loa (eye worm) hypothetical protein 0.0636 0.3647 0.463
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0054 0.0193 0.0297
Schistosoma mansoni hypothetical protein 0.0204 0.1083 0.1248
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0049 0.0165 0.0199
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.007 0.0075
Echinococcus granulosus voltage dependent calcium channel 0.0048 0.0159 0.0191
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0049 0.0165 0.0209
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.007 0.0089
Schistosoma mansoni hypothetical protein 0.0132 0.0656 0.075
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.007 0.0089
Brugia malayi Calcium binding EGF domain containing protein 0.0132 0.0656 0.0853
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0165 0.2534
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0089
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0636 0.3647 0.4746
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0168 0.0182
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.016 0.0195
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0049 0.0165 0.0199
Brugia malayi EGF-like domain containing protein 0.0132 0.0656 0.0853
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0104 0.0123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.007 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.007 0.0089
Schistosoma mansoni carbonic anhydrase 0.1469 0.8595 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0049 0.0165 0.0178
Onchocerca volvulus 0.0033 0.007 0.0095
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0135 0.0671 0.0859
Mycobacterium ulcerans carbonic anhydrase 0.1469 0.8595 0.8594
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.007 0.0075
Onchocerca volvulus 0.0081 0.0355 0.0562
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Brugia malayi P38 map kinase family protein 2 0.0152 0.0772 0.1004
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0284 0.1558 0.2097
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.0772 0.0993
Brugia malayi notch-like transmembrane receptor 0.0132 0.0656 0.0853
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0085 0.0374 0.2761
Plasmodium vivax sulfate transporter, putative 0.0039 0.0104 0.1523
Echinococcus granulosus microsomal glutathione S transferase 3 0.0135 0.0671 0.0859
Brugia malayi Animal haem peroxidase family protein 0.105 0.6106 0.7946
Echinococcus granulosus peroxidasin 0.105 0.6106 0.7942
Echinococcus granulosus protein jagged 2 0.0132 0.0656 0.0839
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0715 0.0916
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.007 0.0075
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0209
Trypanosoma brucei carbonic anhydrase-like protein 0.1316 0.7684 1
Trichomonas vaginalis conserved hypothetical protein 0.1706 1 1
Brugia malayi Muscle positioning protein 4 0.0132 0.0656 0.0853
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.007 0.0091
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0049 0.0165 0.0178
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0104 0.0123
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0089
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0049 0.0165 0.0178
Schistosoma mansoni voltage-gated cation channel 0.0048 0.0159 0.0171
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0039 0.0104 0.0094
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0132 0.0656 0.1056
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Brugia malayi EGF-like domain containing protein 0.0132 0.0656 0.0853
Onchocerca volvulus Slit protein homolog 0.0132 0.0656 0.1056
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.0772 0.0993
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0039 0.0104 0.0094
Mycobacterium leprae Probable transmembrane transport protein 0.0284 0.1558 0.1751
Loa Loa (eye worm) notch protein 0.0132 0.0656 0.0833
Echinococcus granulosus neurogenic locus notch protein 0.0132 0.0656 0.0839
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0049 0.0165 0.0214
Echinococcus multilocularis sodium and chloride dependent glycine 0.0049 0.0165 0.0199
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0209
Onchocerca volvulus 0.0132 0.0656 0.1056
Echinococcus granulosus cytochrome c oxidase subunit II 0.0179 0.0936 0.1204
Brugia malayi Delta serrate ligand family protein 0.0132 0.0656 0.0853
Onchocerca volvulus Peroxidasin homolog 0.105 0.6106 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.007 0.0091
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0048 0.0159 0.0171
Brugia malayi EGF-like domain containing protein 0.0132 0.0656 0.0853
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.007 0.0075
Mycobacterium ulcerans epoxide hydrolase EphA 0.0197 0.104 0.1031
Onchocerca volvulus Peroxidase homolog 0.105 0.6106 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.007 0.0075
Onchocerca volvulus 0.0291 0.16 0.2606
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0048 0.0159 0.0191
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0209
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Loa Loa (eye worm) hypothetical protein 0.0636 0.3647 0.463
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Schistosoma mansoni hypothetical protein 0.0636 0.3647 0.4235
Schistosoma mansoni carbonic anhydrase-related 0.0636 0.3647 0.4235
Loa Loa (eye worm) norepinephrine transporter 0.0291 0.16 0.2032
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0291 0.16 0.2083
Brugia malayi follicle stimulating hormone receptor 0.029 0.1595 0.2076
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0089
Brugia malayi Animal haem peroxidase family protein 0.105 0.6106 0.7946
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0636 0.3647 0.4746
Toxoplasma gondii transporter, cation channel family protein 0.0048 0.0159 0.0156
Echinococcus multilocularis thyroid hormone receptor alpha 0.0185 0.097 0.1249
Loa Loa (eye worm) calcium channel 0.0048 0.0159 0.0202
Echinococcus granulosus protein jagged 1 0.0132 0.0656 0.0839
Echinococcus granulosus carbonic anhydrase 0.0636 0.3647 0.4737
Schistosoma mansoni notch 0.0132 0.0657 0.0751
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0089
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0209
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.0772 0.099
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.007 0.0091
Onchocerca volvulus 0.0132 0.0656 0.1056
Plasmodium vivax amine transporter, putative 0.0049 0.0165 0.2534
Loa Loa (eye worm) carbonic anhydrase 3 0.1316 0.7684 0.9756
Onchocerca volvulus 0.0049 0.0165 0.025
Entamoeba histolytica ankyrin, putative 0.0085 0.0375 0.0255
Onchocerca volvulus Chorion peroxidase homolog 0.105 0.6106 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.001 0.0012
Loa Loa (eye worm) blistered cuticle protein 3 0.105 0.6106 0.7752
Echinococcus multilocularis neurogenic locus protein delta 0.0132 0.0656 0.0839
Loa Loa (eye worm) solute carrier family 6 member 4 0.0291 0.16 0.2032
Schistosoma mansoni sodium/chloride dependent transporter 0.0049 0.0165 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0185 0.097 0.1116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.007 0.0089
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.0772 0.0888
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1172 0.6828 1
Schistosoma mansoni carbonic anhydrase-related 0.0636 0.3647 0.4235
Toxoplasma gondii hypothetical protein 0.0043 0.0124 0.0058
Echinococcus granulosus neurogenic locus notch protein 0.0132 0.0656 0.0839
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.007 0.0091
Echinococcus granulosus protein jagged 2 0.0132 0.0656 0.0839
Echinococcus multilocularis voltage dependent calcium channel 0.0048 0.0159 0.0191
Echinococcus granulosus notch 0.0132 0.0656 0.0839
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1469 0.8595 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.007 0.0091
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0049 0.0165 1
Echinococcus granulosus geminin 0.0204 0.1083 0.1396
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1316 0.7684 0.9756
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.007 0.0067
Brugia malayi hypothetical protein 0.0049 0.0165 0.0214
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0054 0.0193 0.0184
Schistosoma mansoni hypothetical protein 0.0132 0.0656 0.075
Onchocerca volvulus Dual oxidase homolog 0.105 0.6106 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0291 0.16 0.185
Brugia malayi Animal haem peroxidase family protein 0.105 0.6106 0.7946
Schistosoma mansoni slit 0.0132 0.0656 0.075
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0033 0.0064 0.0082
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0132 0.0656 0.075
Loa Loa (eye worm) animal heme peroxidase 0.105 0.6106 0.7752
Onchocerca volvulus 0.0054 0.0193 0.0297
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.0772 0.099
Loa Loa (eye worm) hypothetical protein 0.1348 0.7876 1
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0054 0.0193 0.3006
Toxoplasma gondii MAPEG family protein 0.0135 0.0671 0.1602
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.007 0.0075
Onchocerca volvulus 0.0132 0.0656 0.1056
Brugia malayi Cytochrome P450 family protein 0.0023 0.001 0.0013
Brugia malayi Cytochrome P450 family protein 0.0036 0.0084 0.0109
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.007 0.0091
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1316 0.7684 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0089
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus granulosus slit 2 protein 0.0132 0.0656 0.0839
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.007 0.0075
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0049 0.0165 0.0178
Echinococcus multilocularis neurogenic locus notch protein 0.0132 0.0656 0.0839
Echinococcus multilocularis neurogenic locus notch protein 0.0132 0.0656 0.0839
Schistosoma mansoni peroxidasin 0.105 0.6106 0.71
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.007 0.0089
Brugia malayi hypothetical protein 0.105 0.6106 0.7946
Onchocerca volvulus 0.105 0.6106 1
Brugia malayi Calcium binding EGF domain containing protein 0.0132 0.0656 0.0853
Schistosoma mansoni cytochrome c oxidase subunit II 0.0147 0.0743 0.0851
Toxoplasma gondii hypothetical protein 0.0049 0.0165 0.0172
Schistosoma mansoni hypothetical protein 0.0152 0.0771 0.0885
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0012 0.0016
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.0772 0.099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.007 0.0075
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0049 0.0165 0.0214
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.007 0.0067
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0636 0.3647 0.463
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.007 0.0095
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0048 0.0159 0.0191
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0049 0.0165 0.0178
Schistosoma mansoni lipoxygenase 0.0099 0.0461 0.0523
Brugia malayi Cytochrome P450 family protein 0.0023 0.001 0.0013
Onchocerca volvulus Putative cubilin 0.0132 0.0656 0.1056
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.0772 0.099
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0089
Toxoplasma gondii EGF family domain-containing protein 0.0132 0.0656 0.1558
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.007 0.0091
Loa Loa (eye worm) animal heme peroxidase 0.105 0.6106 0.7752
Brugia malayi GCC2 and GCC3 family protein 0.0132 0.0656 0.0853
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1316 0.7684 0.8939
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1316 0.7684 0.8939
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus granulosus sodium and chloride dependent glycine 0.0049 0.0165 0.0199
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.007 0.0091
Loa Loa (eye worm) hypothetical protein 0.0043 0.0124 0.0158
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus granulosus carbonic anhydrase II 0.1316 0.7684 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0049 0.0165 0.0214
Loa Loa (eye worm) animal heme peroxidase 0.105 0.6106 0.7752
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0132 0.0656 0.0853
Loa Loa (eye worm) animal heme peroxidase 0.105 0.6106 0.7752
Echinococcus granulosus fibropellin Ia 0.0132 0.0656 0.0839
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.007 0.0091
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0104 0.0123
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0715 0.0916
Brugia malayi Calcium binding EGF domain containing protein 0.0132 0.0656 0.0853
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.007 0.0091
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0048 0.0159 0.0191
Leishmania major carbonic anhydrase family protein, putative 0.1469 0.8595 1
Brugia malayi Animal haem peroxidase family protein 0.105 0.6106 0.7946
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Loa Loa (eye worm) hypothetical protein 0.0043 0.0124 0.0158
Echinococcus granulosus dynactin 5 p25 0.0085 0.0374 0.0472
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0588 0.3363 0.3904
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0054 0.0193 0.005
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Onchocerca volvulus Peroxidasin homolog 0.105 0.6106 1
Echinococcus multilocularis serotonin transporter 0.0291 0.16 0.207
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0049 0.0165 0.0199
Schistosoma mansoni carbonic anhydrase 0.0636 0.3647 0.4235
Onchocerca volvulus 0.0132 0.0656 0.1056
Echinococcus multilocularis slit 2 protein 0.0132 0.0656 0.0839
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0048 0.0159 0.0207
Schistosoma mansoni notch 0.0132 0.0656 0.075
Leishmania major hypothetical protein, conserved 0.0049 0.016 0.0175
Brugia malayi nuclear hormone receptor 0.0033 0.007 0.0091
Onchocerca volvulus 0.0132 0.0656 0.1056
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.0772 0.098
Loa Loa (eye worm) voltage-dependent calcium channel 0.0048 0.0159 0.0202
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0049 0.0165 0.0199
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1316 0.7684 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0159 0.0202
Schistosoma mansoni hypothetical protein 0.0132 0.0656 0.075
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0049 0.0165 0.0172
Echinococcus multilocularis peroxidasin 0.105 0.6106 0.7942
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0636 0.3647 0.4746
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0398 0.0503
Echinococcus multilocularis fat cadherin tumor suppressor 0.0132 0.0656 0.0839
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0636 0.3647 0.4746
Brugia malayi ecdysteroid receptor 0.0033 0.007 0.0091
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0209
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0398 0.0503
Echinococcus multilocularis carbonic anhydrase 0.0636 0.3647 0.4737
Echinococcus multilocularis carbonic anhydrase 0.0636 0.3647 0.4737
Loa Loa (eye worm) hypothetical protein 0.105 0.6106 0.7752
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0048 0.0159 0.0194
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0048 0.0159 0.0191
Plasmodium falciparum carbonic anhydrase 0.0636 0.3647 1
Onchocerca volvulus 0.0049 0.0165 0.025
Brugia malayi EGF-like domain containing protein 0.0132 0.0656 0.0853
Plasmodium falciparum amino acid transporter, putative 0.0049 0.0165 0.042
Echinococcus multilocularis protein jagged 2 0.0132 0.0656 0.0839
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0125 0.0614 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.007 0.0075
Schistosoma mansoni cell polarity protein 0.0132 0.0656 0.075
Echinococcus granulosus neurogenic locus protein delta 0.0132 0.0656 0.0839
Loa Loa (eye worm) CYP4Cod1 0.0023 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus granulosus voltage dependent calcium channel 0.0048 0.0159 0.0191
Onchocerca volvulus 0.105 0.6106 1
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0197 0.104 0.132
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.0772 0.099
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0048 0.0159 0.0191
Echinococcus granulosus neural cadherin 0.0132 0.0656 0.0839
Brugia malayi Blistered cuticle protein 3 0.105 0.6106 0.7946
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0054 0.0193 0.0498
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0016
Giardia lamblia High cysteine protein 0.0132 0.0656 0.5
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1316 0.7684 1
Mycobacterium ulcerans hypothetical protein 0.0049 0.016 0.015
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0048 0.0159 0.0194
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1316 0.7684 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0049 0.0165 0.0199
Brugia malayi EGF-like domain containing protein 0.0132 0.0656 0.0853
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0048 0.0159 0.0191
Brugia malayi Cadherin domain containing protein 0.0132 0.0656 0.0853
Brugia malayi EGF-like domain containing protein 0.0132 0.0656 0.0853
Mycobacterium leprae PROBABLE TRANSFERASE 0.0081 0.0355 0.0341
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0049 0.0165 0.0209
Loa Loa (eye worm) Notch2 0.0132 0.0656 0.0833
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.007 0.0075
Loa Loa (eye worm) hypothetical protein 0.0033 0.007 0.0089
Echinococcus multilocularis neural cadherin 0.0132 0.0656 0.0839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.007 0.0089
Entamoeba histolytica carbonic anhydrase, putative 0.1469 0.8595 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.007 0.0075
Toxoplasma gondii hypothetical protein 0.0049 0.0165 0.0172
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.0772 0.099
Schistosoma mansoni hypothetical protein 0.0132 0.0656 0.075
Echinococcus granulosus neurogenic locus notch protein 4 0.0132 0.0656 0.0839
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Echinococcus multilocularis sodium and chloride dependent glycine 0.0049 0.0165 0.0199
Echinococcus granulosus sodium and chloride dependent glycine 0.0049 0.0165 0.0199
Loa Loa (eye worm) serotonin transporter b 0.0291 0.16 0.2032
Echinococcus granulosus FTZ F1 alpha 0.0033 0.007 0.0075
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Schistosoma mansoni microsomal glutathione s-transferase 0.0135 0.0671 0.0768
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0209
Echinococcus granulosus carbonic anhydrase 0.0636 0.3647 0.4737
Loa Loa (eye worm) hypothetical protein 0.0291 0.16 0.2032
Echinococcus granulosus serotonin transporter 0.0291 0.16 0.207
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0179 0.0936 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.007 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.016 0.0195
Schistosoma mansoni sodium/chloride dependent transporter 0.0291 0.16 0.185
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.007 0.0075
Loa Loa (eye worm) hypothetical protein 0.0291 0.16 0.2032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.007 0.0091
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0039 0.0104 0.0252
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0818 0.473 0.6855
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0048 0.0159 0.0191
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Schistosoma mansoni notch 0.0132 0.0656 0.075
Brugia malayi Doublecortin family protein 0.0024 0.0012 0.0016
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.007 0.0075
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0054 0.0193 0.0297
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0636 0.3647 0.4746
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0054 0.0193 0.0297
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0084 0.0106
Brugia malayi steroid hormone receptor 0.0033 0.007 0.0091
Onchocerca volvulus 0.105 0.6106 1
Trichomonas vaginalis conserved hypothetical protein 0.1706 1 1
Brugia malayi hypothetical protein 0.0024 0.0012 0.0016
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.0772 0.0993
Echinococcus multilocularis carbonic anhydrase II 0.1316 0.7684 1
Schistosoma mansoni thyroid hormone receptor 0.0185 0.097 0.1116
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.016 0.0195
Loa Loa (eye worm) hypothetical protein 0.0132 0.0656 0.0833
Schistosoma mansoni hypothetical protein 0.0132 0.0656 0.075
Schistosoma mansoni notch 0.0132 0.0656 0.075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.007 0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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