Detailed information for compound 2072860

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.303 | Formula: C18H21BrN6O
  • H donors: 0 H acceptors: 4 LogP: 1.14 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1nccc1CN1CCOC(C1)c1cccc(n1)c1cncnc1.Br
  • InChi: 1S/C18H20N6O.BrH/c1-23-15(5-6-21-23)11-24-7-8-25-18(12-24)17-4-2-3-16(22-17)14-9-19-13-20-10-14;/h2-6,9-10,13,18H,7-8,11-12H2,1H3;1H
  • InChiKey: FUABNBHATINTCG-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia TM efflux prot 0.0012 0.0002 0.205
Plasmodium falciparum thioredoxin reductase 0.0058 0.0038 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0167 0.0124 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0015 0.0015
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0015 0.3638
Echinococcus granulosus monocarboxylate transporter 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0009 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0028 0.0015 0.0015
Plasmodium falciparum transporter, putative 0.0028 0.0015 0.3941
Echinococcus granulosus major facilitator superfamily domain containing protein 0.0012 0.0002 0.0002
Plasmodium falciparum metabolite/drug transporter, putative 0.0012 0.0002 0.0476
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0131 0.0096 0.8909
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Trypanosoma brucei unspecified product 0.0014 0.0004 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Onchocerca volvulus 0.0051 0.0033 0.0031
Echinococcus multilocularis synaptic vesicle 2 protein 0.0012 0.0002 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0015 0.0015
Giardia lamblia Multidrug resistance protein B 0.0012 0.0002 0.205
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0028 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.0253 0.0191 0.0191
Onchocerca volvulus 0.0036 0.0021 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0008 0.0008
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0015 0.3941
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0008 0.219
Echinococcus multilocularis bloom syndrome protein 0.0023 0.001 0.001
Echinococcus multilocularis synaptic vesicular amine transporter 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0021 0.0021
Toxoplasma gondii hypothetical protein 0.0012 0.0002 0.0476
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0008 0.0008
Echinococcus granulosus monocarboxylate transporter 0.0012 0.0002 0.0002
Echinococcus granulosus bloom syndrome protein 0.0023 0.001 0.001
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0012 0.0002 0.0476
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0021 0.0021
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Echinococcus multilocularis monocarboxylate transporter 0.0012 0.0002 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0008 0.219
Plasmodium falciparum glutathione reductase 0.0058 0.0038 1
Brugia malayi hypothetical protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Giardia lamblia Hypothetical protein 0.0012 0.0002 0.205
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0008 0.0008
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0015 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0131 0.0096 0.8909
Brugia malayi Hypothetical transporter C09D4.1 0.0012 0.0002 0.0002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0009 0.0322
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0008 0.219
Mycobacterium tuberculosis Probable reductase 0.0131 0.0096 0.8909
Echinococcus multilocularis major facilitator superfamily domain containing protein 0.0012 0.0002 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0008 0.9531
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0012 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0008 0.0303
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0008 0.0007
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0008 0.985
Schistosoma mansoni vesicular amine transporter 0.0012 0.0002 0.0002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0033 0.0033
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 1.2755 1 1
Giardia lamblia MDR-type permease 0.0012 0.0002 0.205
Schistosoma mansoni drug transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Plasmodium vivax amine transporter, putative 0.0028 0.0015 0.3638
Brugia malayi transporter 0.0012 0.0002 0.0002
Schistosoma mansoni protein transport protein Sec13 0.0012 0.0002 0.0002
Schistosoma mansoni oxalate:formate antiporter 0.0012 0.0002 0.0002
Giardia lamblia hypothetical protein 0.0012 0.0002 0.205
Brugia malayi follicle stimulating hormone receptor 0.025 0.0189 0.0189
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0008 0.4945
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0146 0.0107 1
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.0191 0.0191
Schistosoma mansoni sugar transporter 0.0012 0.0002 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.002 0.002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0000000000033583 0.00000000088904
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Echinococcus multilocularis transfer RNA-Leu 0.0012 0.0002 0.0002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0009 0.0009
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Brugia malayi hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0021 0.0021
Trypanosoma brucei unspecified product 0.0014 0.0004 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0008 0.0007
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus multilocularis sugar phosphate exchanger solute carrier family 0.0012 0.0002 0.0002
Echinococcus multilocularis vesicular glutamate transporter 0.0012 0.0002 0.0002
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.001 0.04
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0008 0.2203
Echinococcus granulosus Solute carrier family 22 5 0.0012 0.0002 0.0002
Echinococcus multilocularis protein spinster 0.0012 0.0002 0.0002
Plasmodium falciparum amino acid transporter, putative 0.0028 0.0015 0.3941
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Echinococcus granulosus Hippocampus abundant transcript 1 protein 0.0012 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0008 0.0007
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0015 0.0015
Echinococcus multilocularis solute carrier family 43 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Schistosoma mansoni phosphate transporter 0.0012 0.0002 0.0002
Echinococcus granulosus major facilitator superfamily domain containing protein 0.0012 0.0002 0.0002
Echinococcus multilocularis vesicular acetylcholine transporter 1.2755 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0008 0.0007
Echinococcus granulosus monocarboxylate transporter 0.0012 0.0002 0.0002
Brugia malayi hypothetical protein 0.0012 0.0002 0.0002
Brugia malayi hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus monocarboxylate transporter 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0008 0.0008
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0004 0.0004
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus monocarboxylate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Plasmodium falciparum major facilitator superfamily-related transporter, putative 0.0012 0.0002 0.0476
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0021 0.0021
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0009 0.0008
Plasmodium falciparum major facilitator superfamily-related transporter, putative 0.0012 0.0002 0.0476
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Echinococcus multilocularis monocarboxylate transporter 0.0012 0.0002 0.0002
Plasmodium vivax glutathione reductase, putative 0.0058 0.0038 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Onchocerca volvulus 0.0028 0.0015 0.0013
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0015 0.0015
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0015 0.0015
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0008 0.0007
Loa Loa (eye worm) thioredoxin reductase 0.0058 0.0038 0.0038
Onchocerca volvulus 0.0028 0.0015 0.0013
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Loa Loa (eye worm) RecQ helicase 0.0023 0.001 0.001
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Schistosoma mansoni transporter spinster-related 0.0012 0.0002 0.0002
Trypanosoma brucei trypanothione reductase 0.0058 0.0038 0.004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0008 0.0008
Schistosoma mansoni phosphate transporter 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Leishmania major DNA polymerase eta, putative 0.0021 0.0009 0.0008
Schistosoma mansoni ap endonuclease 0.002 0.0008 0.0008
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Giardia lamblia DINP protein human, muc B family 0.0021 0.0009 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0146 0.0107 1
Plasmodium vivax thioredoxin reductase, putative 0.0058 0.0038 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Giardia lamblia Sugar transport family protein 0.0012 0.0002 0.205
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Echinococcus granulosus solute carrier family 43 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Echinococcus multilocularis major facilitator superfamily domain containing protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0146 0.0107 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0028 0.0015 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0008 0.219
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0008 0.985
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.0191 0.0191
Onchocerca volvulus 0.0288 0.0219 0.0217
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Echinococcus multilocularis dna polymerase eta 0.0021 0.0009 0.0009
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0009 0.0008
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Schistosoma mansoni drug efflux protein-related 0.0012 0.0002 0.0002
Schistosoma mansoni solute carrier family 37 member 2 (glycerol-3-phosphate transporter 0.0012 0.0002 0.0002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0008 0.9269
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0002 0.0017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0008 0.9269
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0008 0.0007
Trichomonas vaginalis set domain proteins, putative 0.0288 0.0219 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.001 0.04
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0021
Plasmodium falciparum glutathione reductase 0.002 0.0008 0.219
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0009 0.0009
Schistosoma mansoni oxalate:formate antiporter 0.0012 0.0002 0.0002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0008 0.0008
Plasmodium falciparum monocarboxylate transporter, putative 0.0012 0.0002 0.0476
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0008 0.941
Toxoplasma gondii hypothetical protein 0.0028 0.0015 0.3941
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus MFS transporter ceroid lipofuscinosis neuronal 0.0012 0.0002 0.0002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0058 0.0038 0.0038
Echinococcus granulosus synaptic vesicle 2 protein 0.0012 0.0002 0.0002
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0009 0.0009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0146 0.0107 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0028 0.0015 0.0015
Echinococcus multilocularis geminin 0.0387 0.0296 0.0296
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.0189 0.0189
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0008 0.0008
Echinococcus granulosus monocarboxylate transporter 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0009 0.0008
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0002
Schistosoma mansoni vesicular acetylcholine transporter 1.2755 1 1
Loa Loa (eye worm) norepinephrine transporter 0.0167 0.0124 0.0124
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.0012 0.0002 0.0476
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0008 0.941
Onchocerca volvulus 0.0167 0.0124 0.0122
Schistosoma mansoni selectively expressed in embryonic epithelia protein-1 0.0012 0.0002 0.0002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0015 0.3941
Schistosoma mansoni oxalate:formate antiporter 0.0012 0.0002 0.0002
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0131 0.0096 0.8909
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0008 0.0007
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0028 0.0015 0.0015
Echinococcus multilocularis MFS transporter ceroid lipofuscinosis neuronal 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Schistosoma mansoni DNA polymerase eta 0.0021 0.0009 0.0009
Schistosoma mansoni drug efflux protein-related 0.0012 0.0002 0.0002
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0012 0.0002 0.0476
Echinococcus multilocularis sodium and chloride dependent glycine 0.0028 0.0015 0.0015
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) solute carrier family 6 member 4 0.0167 0.0124 0.0124
Schistosoma mansoni survival motor neuron protein 0.0051 0.0033 0.0033
Echinococcus granulosus sodium dependent phosphate transport protein 1 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Schistosoma mansoni solute carrier family 37 member 2 (glycerol-3-phosphate transporter 0.0012 0.0002 0.0002
Echinococcus multilocularis monocarboxylate transporter 0.0012 0.0002 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0008 0.0007
Leishmania major DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Echinococcus granulosus synaptic vesicle 2 protein 0.0012 0.0002 0.0002
Trypanosoma cruzi C-8 sterol isomerase, putative 1.1352 0.8899 1
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0058 0.0038 0.004
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0008 0.0007
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Echinococcus multilocularis solute carrier family 43 0.0012 0.0002 0.0002
Plasmodium falciparum major facilitator superfamily-related transporter, putative 0.0012 0.0002 0.0476
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0008 0.0303
Echinococcus multilocularis serotonin transporter 0.0167 0.0124 0.0124
Loa Loa (eye worm) glutathione reductase 0.0058 0.0038 0.0038
Toxoplasma gondii zinc finger protein 36 family 3 protein 0.0012 0.0002 0.0476
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Schistosoma mansoni transport proetin (smap-4-related) 0.0012 0.0002 0.0002
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0015 0.0015
Brugia malayi Pre-SET motif family protein 0.0036 0.0021 0.0021
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0005 0.1208
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Schistosoma mansoni feline leukemia virus subgroup C receptor-related 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Echinococcus granulosus Glycerol 3 phosphate transporter 0.0012 0.0002 0.0002
Echinococcus multilocularis vesicular glutamate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0167 0.0124 0.0124
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0012 0.0002 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0009 1
Echinococcus multilocularis monocarboxylate transporter 0.0012 0.0002 0.0002
Plasmodium falciparum pantothenate transporter 0.0012 0.0002 0.0476
Echinococcus multilocularis major facilitator superfamily domain containing protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0028 0.0015 0.0015
Echinococcus granulosus monocarboxylate transporter 0.0012 0.0002 0.0002
Echinococcus granulosus major facilitator superfamily domain containing protein 0.0012 0.0002 0.0002
Schistosoma mansoni solute carrier family 17 member 7 (vesicular glutamate transporter 0.0012 0.0002 0.0002
Schistosoma mansoni vesicular amine transporter 0.0012 0.0002 0.0002
Echinococcus granulosus solute carrier family 43 0.0012 0.0002 0.0002
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0028 0.0015 0.0015
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0007 0.0007
Brugia malayi transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus multilocularis sodium dependent phosphate transport protein 1 0.0012 0.0002 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0028 0.0015 0.0015
Trypanosoma brucei unspecified product 0.0021 0.0009 0.0008
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0015 0.0015
Giardia lamblia Hypothetical protein 0.0012 0.0002 0.205
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0015 0.0015
Schistosoma mansoni feline leukemia virus subgroup C receptor-related 0.0012 0.0002 0.0002
Echinococcus granulosus sodium and chloride dependent glycine 0.0028 0.0015 0.0015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0008 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0008 0.9269
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0009 1
Schistosoma mansoni ap endonuclease 0.002 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0387 0.0296 0.0296
Brugia malayi hypothetical protein 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0012 0.0002 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0015 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0131 0.0096 0.8909
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0008 0.0007
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Toxoplasma gondii hypothetical protein 0.0028 0.0015 0.3941
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Echinococcus granulosus vesicular acetylcholine transporter 1.2755 1 1
Giardia lamblia Hypothetical protein 0.0012 0.0002 0.205
Leishmania major trypanothione reductase 0.0058 0.0038 0.004
Schistosoma mansoni sialin (solute carrier family 17 member 5) (sodium/sialic acid cotransporter) (ast) (membrane glycoprotein hp59) 0.0012 0.0002 0.0002
Schistosoma mansoni oxalate:formate antiporter 0.0012 0.0002 0.0002
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0009 0.0322
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0008 0.2216
Mycobacterium tuberculosis Probable dehydrogenase 0.0131 0.0096 0.8909
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.001 0.001
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Brugia malayi Thioredoxin reductase 0.0058 0.0038 0.0038
Echinococcus granulosus serotonin transporter 0.0167 0.0124 0.0124
Echinococcus granulosus vesicular glutamate transporter 0.0012 0.0002 0.0002
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0002 0.0529
Toxoplasma gondii hypothetical protein 0.0012 0.0002 0.0476
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.0191 0.0191
Onchocerca volvulus 0.0028 0.0015 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0021 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0015 0.0015
Schistosoma mansoni sodium/chloride dependent transporter 0.0167 0.0124 0.0124
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0028 0.0015 0.0015
Echinococcus multilocularis sugar phosphate exchanger 3 0.0012 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0004 0.0004
Echinococcus granulosus feline leukemia virus subgroup C 0.0012 0.0002 0.0002
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Echinococcus granulosus sugar phosphate exchanger 3 0.0012 0.0002 0.0002
Echinococcus granulosus dna polymerase eta 0.0021 0.0009 0.0009
Trypanosoma brucei C-8 sterol isomerase, putative 1.1352 0.8899 1
Schistosoma mansoni hypothetical protein 0.0387 0.0296 0.0296
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0008 0.1799
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0028 0.0015 0.0015
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0008 0.0298
Echinococcus granulosus vesicular glutamate transporter 0.0012 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0051 0.0033 0.0033
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0008 0.0298
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0009 0.0009
Plasmodium vivax SET domain protein, putative 0.0036 0.0021 0.5373
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0008 0.0007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0009 0.0009
Brugia malayi ERG2 and Sigma1 receptor like protein 1.1352 0.8899 0.8899
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0167 0.0124 0.0124
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Echinococcus multilocularis Glycerol 3 phosphate transporter 0.0012 0.0002 0.0002
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0008 0.0007
Echinococcus multilocularis monocarboxylate transporter 0.0012 0.0002 0.0002
Plasmodium falciparum thioredoxin reductase 0.002 0.0008 0.219
Leishmania major C-8 sterol isomerase-like protein 1.1352 0.8899 1
Loa Loa (eye worm) hypothetical protein 0.5802 0.4545 0.4545
Echinococcus multilocularis Major facilitator superfamily, general substrate transporter 0.0012 0.0002 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0058 0.0038 0.0038
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0008 0.0615
Echinococcus granulosus oxalate:formate antiporter 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) serotonin transporter b 0.0167 0.0124 0.0124
Brugia malayi glutathione reductase 0.0058 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Schistosoma mansoni sugar transporter 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Toxoplasma gondii thioredoxin reductase 0.0058 0.0038 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0009 0.0663
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Schistosoma mansoni tetracycline-efflux transporter 0.0012 0.0002 0.0002
Giardia lamblia Multidrug resistance protein B 0.0012 0.0002 0.205
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus MFS transporter ceroid lipofuscinosis neuronal 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0008 0.0624
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0028 0.0015 0.0015
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0167 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0252 0.0191 0.0191
Schistosoma mansoni sodium-dependent phosphate transporter 0.0012 0.0002 0.0002
Echinococcus granulosus sugar phosphate exchanger 0.0012 0.0002 0.0002
Schistosoma mansoni sodium/chloride dependent transporter 0.0028 0.0015 0.0015
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0012 0.0002 0.0476
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0028 0.0015 0.0015
Echinococcus granulosus protein spinster 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 1.1352 0.8899 0.8899
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Echinococcus granulosus Major facilitator superfamily general substrate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hippocampus abundant transcript 1a 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0131 0.0096 0.8909
Echinococcus granulosus dna polymerase kappa 0.0021 0.0009 0.0009
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0167 0.0124 0.0124
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0058 0.0038 0.3416
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0008 0.0007
Brugia malayi hypothetical protein 0.0252 0.0191 0.0191
Echinococcus multilocularis MFS transporter ceroid lipofuscinosis neuronal 0.0012 0.0002 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0008 0.0007
Giardia lamblia Hypothetical protein 0.0012 0.0002 0.205
Toxoplasma gondii exonuclease III APE 0.002 0.0008 0.2216
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0008 1
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.0002 0.0476
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0167 0.0124 0.0124
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0012 0.0002 0.0476
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0005 0.0807
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0008 0.0007
Echinococcus multilocularis feline leukemia virus subgroup C 0.0012 0.0002 0.0002
Schistosoma mansoni oxalate:formate antiporter 0.0012 0.0002 0.0002
Echinococcus granulosus synaptic vesicular amine transporter 0.0012 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0021 0.0021
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0021 0.5593
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0008 0.0007
Echinococcus multilocularis monocarboxylate transporter 0.0012 0.0002 0.0002
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0008 0.0009
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.0002 0.0002
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0008 0.9419
Schistosoma mansoni sodium/sialic acid cotransporter 0.0012 0.0002 0.0002
Echinococcus granulosus geminin 0.0387 0.0296 0.0296
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0009 0.0008
Plasmodium falciparum monocarboxylate transporter, putative 0.0012 0.0002 0.0476
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0009 0.0663
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus multilocularis Hippocampus abundant transcript 1 protein 0.0012 0.0002 0.0002
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0028 0.0015 0.0015
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0028 0.0015 0.0015
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0008 0.1826
Onchocerca volvulus Vesicular acetylcholine transporter homolog 1.2755 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0021 0.0021
Giardia lamblia Hypothetical protein 0.0012 0.0002 0.205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Brugia malayi probable sodium-dependent inorganic phosphate cotransporter 0.0012 0.0002 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0008 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0009 0.0008
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0028 0.0015 0.3941
Schistosoma mansoni solute carrier family 37 member 2 (glycerol-3-phosphate transporter 0.0012 0.0002 0.0002
Echinococcus multilocularis oxalate:formate antiporter 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Echinococcus multilocularis monocarboxylate transporter 0.0012 0.0002 0.0002
Echinococcus multilocularis synaptic vesicle 2 protein 0.0012 0.0002 0.0002
Schistosoma mansoni adenylate cyclase 0.0012 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0008 0.0007
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0004 0.0002
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0009 0.0008
Giardia lamblia Major facilitator family transporter 0.0012 0.0002 0.205
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0009 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0008 0.1799
Schistosoma mansoni monocarboxylate transporter 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus monocarboxylate transporter 0.0012 0.0002 0.0002
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.0002 0.0002
Brugia malayi Abnormal catecholamine distribution protein 1 0.0012 0.0002 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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