TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 513.431 | Formula: C21H25F6N3O5
H donors: 3 H acceptors: 6 LogP: 0.62 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.O=C1CC(C2(N1)CCN(CC2)CC1CC1)c1ccncc1
InChi: 1S/C17H23N3O.2C2HF3O2/c21-16-11-15(14-3-7-18-8-4-14)17(19-16)5-9-20(10-6-17)12-13-1-2-13;2*3-2(4,5)1(6)7/h3-4,7-8,13,15H,1-2,5-6,9-12H2,(H,19,21);2*(H,6,7)
InChiKey: LKQIBBIXWILDKK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.004	0.0053	0.0169
Loa Loa (eye worm)	transcription factor SMAD2	0.0048	0.0066	0.01
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Schistosoma mansoni	gliotactin	0.0321	0.0536	0.0536
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0018	0.0015	0.0793
Loa Loa (eye worm)	blistered cuticle protein 3	0.0177	0.0289	0.0438
Plasmodium vivax	importin-beta 2, putative	0.0021	0.0019	0.5824
Brugia malayi	EGF-like domain containing protein	0.0057	0.0082	0.0125
Echinococcus granulosus	follistatin	0.0018	0.0015	0.0022
Onchocerca volvulus		0.0123	0.0195	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Onchocerca volvulus		0.0123	0.0195	0.0668
Schistosoma mansoni	laminin gamma-3 chain	0.0057	0.0082	0.0082
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0001	0.0007
Chlamydia trachomatis	glycogen phosphorylase	0.1663	0.2846	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.1663	0.2846	1
Onchocerca volvulus		0.0036	0.0045	0.0142
Echinococcus multilocularis	chromobox protein 1	0.0028	0.0032	0.0048
Brugia malayi	Peroxidasin	0.0177	0.0289	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0001	0.0007
Brugia malayi	Importin beta-1 subunit	0.0021	0.0019	0.0029
Echinococcus multilocularis		0.0123	0.0195	0.0295
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0519	0.0876	0.0876
Onchocerca volvulus		0.0123	0.0195	0.0668
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0123	0.0195	0.2222
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0321	0.0536	0.0536
Echinococcus multilocularis	glycogen phosphorylase	0.1663	0.2846	0.4314
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0022
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.001	0.0001	0.5
Onchocerca volvulus	4.1 G protein, putative homolog	0.0123	0.0195	0.0668
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0123	0.0195	0.0195
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0065	0.0096	0.0784
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0321	0.0536	0.4392
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0118	0.0187	0.0284
Onchocerca volvulus		0.0123	0.0195	0.0668
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0003	0.0007
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0321	0.0536	0.0813
Echinococcus multilocularis	carbonic anhydrase II	0.0519	0.0876	0.1328
Brugia malayi	EGF-like domain containing protein	0.0057	0.0082	0.0125
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.001	0.0001	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Echinococcus multilocularis	neural cadherin	0.0057	0.0082	0.0125
Schistosoma mansoni	hypothetical protein	0.0057	0.0082	0.0082
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0001	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0055	0.0083
Echinococcus multilocularis	neurogenic locus protein delta	0.0057	0.0082	0.0125
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Plasmodium falciparum	glutathione reductase	0.001	0.0001	0.0033
Schistosoma mansoni	glycogen phosphorylase	0.1663	0.2846	0.2846
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0123	0.0195	0.0195
Trichomonas vaginalis	glycogen phosphorylase, putative	0.1663	0.2846	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0045
Treponema pallidum	NADH oxidase	0.001	0.0001	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.3843	0.6597	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0177	0.0289	0.1
Brugia malayi	Carboxylesterase family protein	0.0321	0.0536	0.0813
Onchocerca volvulus		0.0321	0.0536	0.1871
Brugia malayi	Calcium binding EGF domain containing protein	0.0057	0.0082	0.0125
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0123	0.0195	0.0195
Plasmodium falciparum	glutathione reductase	0.0029	0.0033	0.175
Schistosoma mansoni	cell polarity protein	0.0057	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Loa Loa (eye worm)	carboxylesterase	0.1901	0.3255	0.4934
Brugia malayi	Animal haem peroxidase family protein	0.0177	0.0289	0.0438
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0057	0.0082	0.0272
Echinococcus granulosus	carbonic anhydrase	0.0118	0.0187	0.0284
Brugia malayi	glutathione reductase	0.0029	0.0033	0.005
Schistosoma mansoni	agrin	0.0018	0.0015	0.0015
Echinococcus granulosus	fibropellin Ia	0.0057	0.0082	0.0125
Onchocerca volvulus	Putative cubilin	0.0057	0.0082	0.0272
Onchocerca volvulus	Glycogen phosphorylase homolog	0.1663	0.2846	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0068
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Loa Loa (eye worm)	agrin synaptic family protein	0.0018	0.0015	0.0022
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0029	0.0033	0.005
Onchocerca volvulus		0.0123	0.0195	0.0668
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0057	0.0082	0.0125
Schistosoma mansoni	acetylcholinesterase	0.0321	0.0536	0.0536
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0123	0.0195	0.0295
Mycobacterium ulcerans	carboxylesterase, LipT	0.0321	0.0536	0.4389
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0057	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0187	0.0284
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.0029	0.0045
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	protein jagged 1	0.0057	0.0082	0.0125
Schistosoma mansoni	hypothetical protein	0.0057	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0011	0.0016
Echinococcus granulosus	neurogenic locus notch protein	0.0057	0.0082	0.0125
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0321	0.0536	0.0813
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0321	0.0536	0.0813
Brugia malayi	Calcium binding EGF domain containing protein	0.0057	0.0082	0.0125
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0123	0.0195	0.2222
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0123	0.0195	0.0643
Trichomonas vaginalis	spcc417.12 protein, putative	0.0321	0.0536	0.1883
Loa Loa (eye worm)	glycogen phosphorylase	0.1663	0.2846	0.4314
Schistosoma mansoni	hypothetical protein	0.0057	0.0082	0.0082
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1901	0.3255	0.3255
Echinococcus granulosus	carbonic anhydrase II	0.0519	0.0876	0.1328
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0123	0.0195	0.0668
Onchocerca volvulus		0.0041	0.0055	0.0176
Echinococcus multilocularis	para nitrobenzyl esterase	0.0321	0.0536	0.0813
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0321	0.0536	0.1871
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0519	0.0876	0.1328
Mycobacterium tuberculosis	Probable oxidoreductase	0.0072	0.0108	0.0886
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0003	0.0007
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0123	0.0195	0.0643
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0057	0.0082	0.0125
Brugia malayi	hypothetical protein	0.0321	0.0536	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Schistosoma mansoni	protein tyrosine phosphatase	0.0123	0.0195	0.0195
Schistosoma mansoni	carbonic anhydrase-related	0.0118	0.0187	0.0187
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Schistosoma mansoni	glycogen phosphorylase	0.1663	0.2846	0.2846
Brugia malayi	Protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Loa Loa (eye worm)	glutathione reductase	0.0029	0.0033	0.005
Echinococcus granulosus	slit 2 protein	0.0057	0.0082	0.0125
Leishmania major	tyrosine specific protein phosphatase, putative	0.0123	0.0195	0.2222
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.1901	0.3255	0.4934
Brugia malayi	EGF-like domain containing protein	0.0057	0.0082	0.0125
Onchocerca volvulus		0.0027	0.0029	0.0087
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.0029	0.0087
Schistosoma mansoni	hypothetical protein	0.0118	0.0187	0.0187
Loa Loa (eye worm)	notch protein	0.0057	0.0082	0.0125
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0321	0.0536	0.4392
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0027	0.0029	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Brugia malayi	EGF-like domain containing protein	0.0057	0.0082	0.0125
Loa Loa (eye worm)	animal heme peroxidase	0.0177	0.0289	0.0438
Echinococcus granulosus	geminin	0.0371	0.0621	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0321	0.0536	0.1871
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Trypanosoma cruzi	trypanothione reductase, putative	0.001	0.0001	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.3843	0.6597	0.6597
Echinococcus granulosus	BC026374 protein S09 family	0.0321	0.0536	0.0813
Echinococcus granulosus	carbonic anhydrase	0.0118	0.0187	0.0284
Onchocerca volvulus		0.0027	0.0029	0.0087
Brugia malayi	Animal haem peroxidase family protein	0.0177	0.0289	0.0438
Brugia malayi	Carboxylesterase family protein	0.0321	0.0536	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.001	0.0001	0.0186
Onchocerca volvulus		0.0123	0.0195	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Onchocerca volvulus	Dual oxidase homolog	0.0177	0.0289	0.1
Schistosoma mansoni	hypothetical protein	0.0057	0.0082	0.0082
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0123	0.0195	0.0295
Echinococcus granulosus	neurogenic locus protein delta	0.0057	0.0082	0.0125
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.3843	0.6597	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0719	0.1221	0.4266
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0017	0.0013	0.0028
Onchocerca volvulus	Peroxidase homolog	0.0177	0.0289	0.1
Toxoplasma gondii	thioredoxin reductase	0.0029	0.0033	0.175
Brugia malayi	Animal haem peroxidase family protein	0.0177	0.0289	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0027	0.0029	0.0045
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.001	0.0001	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Leishmania major	carbonic anhydrase-like protein	0.0519	0.0876	1
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0036	0.0045	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Echinococcus granulosus	neural cadherin	0.0057	0.0082	0.0125
Trypanosoma brucei	importin beta-1 subunit, putative	0.0021	0.0019	0.0218
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0123	0.0195	0.0295
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0321	0.0536	0.0536
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0321	0.0536	0.4392
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0719	0.1221	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0123	0.0195	0.0295
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.001	0.0001	0.0005
Echinococcus granulosus	agrin	0.0018	0.0015	0.0022
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0123	0.0195	0.0295
Brugia malayi	EGF-like domain containing protein	0.0057	0.0082	0.0125
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0123	0.0195	0.2222
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0011	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Brugia malayi	Cadherin domain containing protein	0.0057	0.0082	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0321	0.0536	0.0813
Echinococcus granulosus	importin subunit beta 1	0.0021	0.0019	0.0029
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.001	0.0001	0.0007
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0072	0.0108	0.0886
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.001	0.0001	0.0007
Echinococcus granulosus	glycogen phosphorylase	0.1663	0.2846	0.4314
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.0029	0.0045
Echinococcus granulosus	notch	0.0057	0.0082	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Echinococcus multilocularis	carbonic anhydrase	0.0118	0.0187	0.0284
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.001	0.0001	0.0007
Echinococcus granulosus	Glycosyl transferase family 35	0.1663	0.2846	0.4314
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0022
Trichomonas vaginalis	pten, drome, putative	0.0123	0.0195	0.0682
Brugia malayi	RNA, U transporter 1	0.0059	0.0084	0.0128
Brugia malayi	Thioredoxin reductase	0.0029	0.0033	0.005
Onchocerca volvulus		0.0057	0.0082	0.0272
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0123	0.0195	0.0195
Toxoplasma gondii	hypothetical protein	0.0118	0.0187	1
Trichomonas vaginalis	importin beta-1, putative	0.0017	0.0012	0.0041
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0029	0.0033	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0068
Onchocerca volvulus		0.0057	0.0082	0.0272
Echinococcus granulosus	acetylcholinesterase	0.1901	0.3255	0.4934
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0018	0.0015	0.0022
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.1058	0.1805	0.1805
Schistosoma mansoni	septate junction protein	0.0057	0.0082	0.0082
Echinococcus granulosus	chromobox protein 1	0.0028	0.0032	0.0048
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0123	0.0195	0.0295
Echinococcus granulosus	chromobox protein 1	0.0028	0.0032	0.0048
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0123	0.0195	0.0195
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0123	0.0195	0.0195
Onchocerca volvulus	Slit protein homolog	0.0057	0.0082	0.0272
Brugia malayi	Heterochromatin protein 1	0.0028	0.0032	0.0048
Onchocerca volvulus		0.0123	0.0195	0.0668
Loa Loa (eye worm)	hypothetical protein	0.004	0.0053	0.008
Loa Loa (eye worm)	heterochromatin protein 1	0.0028	0.0032	0.0048
Leishmania major	importin beta-1 subunit, putative	0.0017	0.0012	0.0141
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Trichomonas vaginalis	chromobox protein, putative	0.0017	0.0013	0.0042
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.001	0.0001	0.0007
Toxoplasma gondii	transporter, major facilitator family protein	0.0027	0.0029	0.157
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0065	0.0096	0.0784
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0027	0.0029	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Echinococcus granulosus	neurogenic locus notch protein	0.0057	0.0082	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Toxoplasma gondii	protease inhibitor PI2	0.0018	0.0015	0.0793
Brugia malayi	hypothetical protein	0.0027	0.0029	0.0045
Entamoeba histolytica	glycogen phosphorylase, putative	0.0719	0.1221	0.4266
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Brugia malayi	hypothetical protein	0.0123	0.0195	0.0295
Brugia malayi	Delta serrate ligand family protein	0.0057	0.0082	0.0125
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0018	0.0015	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0123	0.0195	0.0295
Echinococcus granulosus	delta-like protein 1	0.0057	0.0082	0.0125
Toxoplasma gondii	EGF family domain-containing protein	0.0057	0.0082	0.4393
Echinococcus multilocularis	acetylcholinesterase	0.1901	0.3255	0.4934
Onchocerca volvulus		0.0123	0.0195	0.0668
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0123	0.0195	0.0195
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.3843	0.6597	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Onchocerca volvulus	Peroxidasin homolog	0.0177	0.0289	0.1
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0027	0.0029	0.0045
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0123	0.0195	0.0295
Giardia lamblia	High cysteine protein	0.0057	0.0082	0.0287
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.004	0.0053	0.008
Brugia malayi	hypothetical protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	importin subunit beta 1	0.0021	0.0019	0.0029
Schistosoma mansoni	peroxidasin	0.0177	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0045
Onchocerca volvulus		0.0057	0.0082	0.0272
Echinococcus granulosus	protein jagged 1	0.0057	0.0082	0.0125
Loa Loa (eye worm)	thioredoxin reductase	0.0029	0.0033	0.005
Schistosoma mansoni	hypothetical protein	0.0057	0.0082	0.0082
Loa Loa (eye worm)	acetylcholinesterase 1	0.1901	0.3255	0.4934
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Echinococcus granulosus	carboxylesterase 5A	0.1901	0.3255	0.4934
Echinococcus granulosus	protein jagged 1	0.0057	0.0082	0.0125
Entamoeba histolytica	glycogenphosphorylase, putative	0.0719	0.1221	0.4266
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0123	0.0195	0.0295
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Plasmodium vivax	thioredoxin reductase, putative	0.0029	0.0033	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0001	0.0007
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.0029	0.0087
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0017	0.0012	0.0041
Trypanosoma cruzi	MFS transporter, putative	0.0027	0.0029	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.049	0.0827	0.1253
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Schistosoma mansoni	carbonic anhydrase	0.0118	0.0187	0.0187
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0011	0.0035
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0123	0.0195	0.0195
Echinococcus granulosus	neurogenic locus notch protein 4	0.0057	0.0082	0.0125
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0018	0.0015	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0187	0.0284
Onchocerca volvulus		0.0321	0.0536	0.1871
Onchocerca volvulus		0.0321	0.0536	0.1871
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Brugia malayi	secreted modular calcium-binding protein 1	0.0018	0.0015	0.0022
Onchocerca volvulus		0.0123	0.0195	0.0668
Onchocerca volvulus		0.0123	0.0195	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0065	0.0096	0.0784
Loa Loa (eye worm)	hypothetical protein	0.1901	0.3255	0.4934
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0123	0.0195	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0719	0.1221	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.004	0.0053	0.008
Echinococcus multilocularis	peroxidasin	0.0177	0.0289	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0321	0.0536	0.0813
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0321	0.0536	0.1883
Schistosoma mansoni	notch	0.0057	0.0082	0.0082
Schistosoma mansoni	notch	0.0057	0.0082	0.0082
Onchocerca volvulus		0.0027	0.0029	0.0087
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0001	0.0007
Schistosoma mansoni	pcd6 interacting protein-related	0.0123	0.0195	0.0195
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Schistosoma mansoni	peroxidasin	0.0177	0.0289	0.0289
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.001	0.0001	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Plasmodium falciparum	thioredoxin reductase	0.0029	0.0033	0.175
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0018	0.0015	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0017	0.0012	0.0041
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0519	0.0876	1
Schistosoma mansoni	organic anion transporter	0.0027	0.0029	0.0029
Loa Loa (eye worm)	animal heme peroxidase	0.0177	0.0289	0.0438
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.001	0.0001	0.5
Onchocerca volvulus		0.0123	0.0195	0.0668
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027	0.0029	0.0045
Schistosoma mansoni	follistatin	0.0018	0.0015	0.0015
Echinococcus multilocularis	neurogenic locus protein delta	0.0057	0.0082	0.0125
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0057	0.0082	0.0125
Echinococcus multilocularis	chromobox protein 1	0.0028	0.0032	0.0048
Echinococcus multilocularis	protein jagged 2	0.0057	0.0082	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0045
Echinococcus multilocularis	slit 2 protein	0.0057	0.0082	0.0125
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0123	0.0195	0.0668
Trypanosoma brucei	trypanothione reductase	0.0029	0.0033	0.0374
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Brugia malayi	prostaglandin transporter	0.0027	0.0029	0.0045
Schistosoma mansoni	hypothetical protein	0.0057	0.0082	0.0082
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0519	0.0876	1
Echinococcus multilocularis	carbonic anhydrase	0.0118	0.0187	0.0284
Onchocerca volvulus		0.0123	0.0195	0.0668
Brugia malayi	hypothetical protein	0.0123	0.0195	0.0295
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0118	0.0187	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0123	0.0195	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0123	0.0195	0.0643
Schistosoma mansoni	protein kinase C mu	0.004	0.0053	0.0053
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0123	0.0195	0.0195
Brugia malayi	Carboxylesterase family protein	0.1901	0.3255	0.4934
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Echinococcus granulosus	protein jagged 2	0.0057	0.0082	0.0125
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0017	0.0012	0.0141
Brugia malayi	GCC2 and GCC3 family protein	0.0057	0.0082	0.0125
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0018	0.0015	0.0793
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0519	0.0876	0.1328
Echinococcus multilocularis	snurportin 1	0.022	0.0362	0.0549
Echinococcus granulosus	para nitrobenzyl esterase	0.0321	0.0536	0.0813
Echinococcus multilocularis	protein jagged 1	0.0057	0.0082	0.0125
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0123	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0123	0.0195	0.0295
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0118	0.0187	0.0284
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0018	0.0015	0.0793
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0123	0.0195	0.0668
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0118	0.0187	0.0284
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0321	0.0536	0.0813
Schistosoma mansoni	glycogen phosphorylase	0.0719	0.1221	0.1221
Onchocerca volvulus		0.0123	0.0195	0.0668
Mycobacterium tuberculosis	Probable reductase	0.0065	0.0096	0.0784
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Entamoeba histolytica	glycogen phosphorylase, putative	0.1663	0.2846	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.001	0.0001	0.0007
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.001	0.0001	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Plasmodium falciparum	importin beta, putative	0.0021	0.0019	0.1019
Trypanosoma brucei	importin beta-1 subunit, putative	0.0021	0.0019	0.0218
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.001	0.0001	0.0001
Echinococcus granulosus	protein jagged 2	0.0057	0.0082	0.0125
Brugia malayi	chromobox protein homolog 3	0.0016	0.0011	0.0016
Onchocerca volvulus		0.0057	0.0082	0.0272
Echinococcus multilocularis	carboxylesterase 5A	0.1901	0.3255	0.4934
Onchocerca volvulus	Peroxidase homolog	0.0177	0.0289	0.1
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0118	0.0187	0.0284
Brugia malayi	Animal haem peroxidase family protein	0.0177	0.0289	0.0438
Echinococcus multilocularis	hypothetical protein	0.0123	0.0195	0.0295
Onchocerca volvulus	Putative organic anion transporter	0.0027	0.0029	0.0087
Loa Loa (eye worm)	animal heme peroxidase	0.0177	0.0289	0.0438
Schistosoma mansoni	hypothetical protein	0.0057	0.0082	0.0082
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0018	0.0015	0.0022
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0123	0.0195	0.0295
Brugia malayi	Carboxylesterase family protein	0.0321	0.0536	0.0813
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.3843	0.6597	1
Brugia malayi	C1-like domain containing protein	0.004	0.0053	0.008
Echinococcus granulosus	carbonic anhydrase	0.0118	0.0187	0.0284
Onchocerca volvulus		0.0057	0.0082	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0321	0.0536	0.0813
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0123	0.0195	0.0295
Echinococcus multilocularis	neurogenic locus notch protein	0.0057	0.0082	0.0125
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0123	0.0195	0.0295
Brugia malayi	Calcium binding EGF domain containing protein	0.0057	0.0082	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0321	0.0536	0.0813
Brugia malayi	Muscle positioning protein 4	0.0057	0.0082	0.0125
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0118	0.0187	0.0284
Onchocerca volvulus	Neurogenic locus notch homolog	0.0057	0.0082	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0187	0.0284
Brugia malayi	Carboxylesterase family protein	0.0321	0.0536	0.0813
Echinococcus granulosus	acetylcholinesterase	0.1901	0.3255	0.4934
Echinococcus multilocularis	agrin	0.0018	0.0015	0.0022
Trichomonas vaginalis	chromobox protein, putative	0.0028	0.0032	0.011
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0123	0.0195	0.2222
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0321	0.0536	0.0536
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.022	0.0362	0.0549
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Echinococcus multilocularis	neurogenic locus notch protein	0.0057	0.0082	0.0125
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.001	0.0001	0.0001
Onchocerca volvulus		0.0177	0.0289	0.1
Onchocerca volvulus		0.0177	0.0289	0.1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0123	0.0195	0.0195
Echinococcus multilocularis	neuroligin	0.0321	0.0536	0.0813
Onchocerca volvulus		0.0177	0.0289	0.1
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0018	0.0015	0.0793
Echinococcus granulosus	snurportin 1	0.022	0.0362	0.0549
Onchocerca volvulus		0.0018	0.0015	0.0035
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0519	0.0876	0.1328
Onchocerca volvulus		0.0123	0.0195	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0321	0.0536	0.0813
Brugia malayi	hypothetical protein	0.0123	0.0195	0.0295
Schistosoma mansoni	slit	0.0057	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Plasmodium falciparum	carbonic anhydrase	0.0118	0.0187	1
Giardia lamblia	Protein tyrosine phosphatase	0.0123	0.0195	0.0682
Echinococcus granulosus	neuroligin	0.0321	0.0536	0.0813
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0123	0.0195	0.0295
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.001	0.0001	0.0186
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.001	0.0001	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Onchocerca volvulus	Peroxidasin homolog	0.0177	0.0289	0.1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0065	0.0096	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0019	0.0029
Echinococcus granulosus	thioredoxin glutathione reductase	0.0029	0.0033	0.005
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0045
Schistosoma mansoni	carbonic anhydrase-related	0.0118	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0022
Schistosoma mansoni	BC026374 protein (S09 family)	0.0321	0.0536	0.0536
Giardia lamblia	Glycogen phosphorylase	0.1663	0.2846	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0123	0.0195	0.0295
Schistosoma mansoni	notch	0.0057	0.0082	0.0082
Echinococcus multilocularis	notch	0.0057	0.0082	0.0125
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Brugia malayi	Cadherin domain containing protein	0.0057	0.0082	0.0125
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Schistosoma mansoni	organic anion transporter	0.0027	0.0029	0.0029
Trypanosoma brucei	carbonic anhydrase-like protein	0.0519	0.0876	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0016	0.0011	0.0021
Loa Loa (eye worm)	animal heme peroxidase	0.0177	0.0289	0.0438
Echinococcus multilocularis	carbonic anhydrase	0.0118	0.0187	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Schistosoma mansoni	carbonic anhydrase-related	0.0118	0.0187	0.0187
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Brugia malayi	Protein-tyrosine phosphatase 1	0.0123	0.0195	0.0295
Loa Loa (eye worm)	carboxylesterase	0.0321	0.0536	0.0813
Brugia malayi	MH2 domain containing protein	0.0048	0.0066	0.01
Echinococcus multilocularis	glycogen phosphorylase	0.1663	0.2846	0.4314
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.001	0.0001	0.0007
Onchocerca volvulus		0.0123	0.0195	0.0668
Schistosoma mansoni	chromobox protein	0.0028	0.0032	0.0032
Echinococcus multilocularis	follistatin	0.0018	0.0015	0.0022
Loa Loa (eye worm)	Notch2	0.0057	0.0082	0.0125
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.001	0.0001	0.0007
Echinococcus multilocularis	Glycosyl transferase, family 35	0.1663	0.2846	0.4314
Brugia malayi	Blistered cuticle protein 3	0.0177	0.0289	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0123	0.0195	0.0295
Brugia malayi	Carboxylesterase family protein	0.1901	0.3255	0.4934
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Trichomonas vaginalis	glycogen phosphorylase, putative	0.1663	0.2846	1
Loa Loa (eye worm)	hypothetical protein	0.0321	0.0536	0.0813
Echinococcus multilocularis	geminin	0.0371	0.0621	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0123	0.0195	0.0195
Loa Loa (eye worm)	carboxylesterase	0.0321	0.0536	0.0813
Schistosoma mansoni	hypothetical protein	0.022	0.0362	0.0362
Brugia malayi	hypothetical protein	0.0123	0.0195	0.0295
Onchocerca volvulus		0.0123	0.0195	0.0668
Brugia malayi	EGF-like domain containing protein	0.0057	0.0082	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Schistosoma mansoni	hypothetical protein	0.0371	0.0621	0.0621
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0072	0.0108	1
Schistosoma mansoni	hypothetical protein	0.0371	0.0621	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0123	0.0195	0.0295
Schistosoma mansoni	protein tyrosine phosphatase	0.0123	0.0195	0.0195
Schistosoma mansoni	notch	0.0057	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Schistosoma mansoni	chromobox protein	0.0028	0.0032	0.0032
Brugia malayi	EGF-like domain containing protein	0.0057	0.0082	0.0125
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0123	0.0195	0.0295
Brugia malayi	hypothetical protein	0.0027	0.0029	0.0045
Plasmodium vivax	glutathione reductase, putative	0.0029	0.0033	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0123	0.0195	0.0195
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Echinococcus granulosus	glycogen phosphorylase	0.1663	0.2846	0.4314
Brugia malayi	Protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Onchocerca volvulus		0.0027	0.0029	0.0087
Brugia malayi	SPARC precursor	0.0018	0.0015	0.0022
Leishmania major	trypanothione reductase	0.0029	0.0033	0.0374
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0123	0.0195	0.0295
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0123	0.0195	0.2222
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0123	0.0195	0.0295
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0072	0.0108	0.0886
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.001	0.0001	0.0007
Onchocerca volvulus		0.0123	0.0195	0.0668
Schistosoma mansoni	notch	0.0057	0.0082	0.0082
Brugia malayi	Animal haem peroxidase family protein	0.0177	0.0289	0.0438
Trichomonas vaginalis	chromobox protein, putative	0.0028	0.0032	0.011
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.001	0.0001	0.0007
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.001	0.0001	0.0001
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0027	0.0029	0.0045
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Echinococcus multilocularis	acetylcholinesterase	0.1901	0.3255	0.4934
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.001	0.0001	0.0033
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0123	0.0195	0.0295
Brugia malayi	carbohydrate phosphorylase	0.1663	0.2846	0.4314
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0123	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Brugia malayi	hypothetical protein	0.0177	0.0289	0.0438
Trichomonas vaginalis	chromobox protein, putative	0.0017	0.0013	0.0042
Trypanosoma cruzi	trypanothione reductase, putative	0.0029	0.0033	0.0374
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0321	0.0536	0.0536
Toxoplasma gondii	HEAT repeat-containing protein	0.0021	0.0019	0.1019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0123	0.0195	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0082	0.0125
Echinococcus multilocularis	fibropellin Ia	0.0057	0.0082	0.0125
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0123	0.0195	0.0295
Plasmodium falciparum	thioredoxin reductase	0.001	0.0001	0.0033
Schistosoma mansoni	importin beta-1	0.0021	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0123	0.0195	0.0295
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0065	0.0096	0.0784
Onchocerca volvulus		0.0123	0.0195	0.0668
Loa Loa (eye worm)	carbonic anhydrase 3	0.0519	0.0876	0.1328
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0027	0.0029	0.0045
Echinococcus granulosus	peroxidasin	0.0177	0.0289	0.0438
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0123	0.0195	0.0195
Brugia malayi	notch-like transmembrane receptor	0.0057	0.0082	0.0125
Loa Loa (eye worm)	MH2 domain-containing protein	0.0048	0.0066	0.01
Schistosoma mansoni	notch	0.0057	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0289	0.0438
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0519	0.0876	0.0876
Echinococcus multilocularis	expressed protein	0.0018	0.0015	0.0022
Toxoplasma gondii	NADPH-glutathione reductase	0.001	0.0001	0.0033

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3503055

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2075736