TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 573.472 | Formula: C30H26Cl2N6O2
H donors: 1 H acceptors: 5 LogP: 7.87 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)c1c(Cc2ccc(cc2)c2ccccc2c2n[nH]nn2)c(nn1c1c(Cl)cccc1Cl)CC1CC1
InChi: 1S/C30H26Cl2N6O2/c1-2-40-30(39)27-23(26(17-19-10-11-19)35-38(27)28-24(31)8-5-9-25(28)32)16-18-12-14-20(15-13-18)21-6-3-4-7-22(21)29-33-36-37-34-29/h3-9,12-15,19H,2,10-11,16-17H2,1H3,(H,33,34,36,37)
InChiKey: KAVXLGDCKNPYMU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Angiotensin II type 1a (AT-1a) receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	25.5 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	348 aa	26.4 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	313 aa	25.6 %
Echinococcus granulosus	growth hormone secretagogue receptor type 1	Angiotensin II type 1a (AT-1a) receptor	359 aa	342 aa	22.2 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.8 %
Brugia malayi	putative neuropeptide receptor NPR1	Angiotensin II type 1a (AT-1a) receptor	359 aa	295 aa	27.1 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	333 aa	21.3 %
Schistosoma mansoni	adenoreceptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	23.7 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II type 1a (AT-1a) receptor	359 aa	306 aa	21.9 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	317 aa	24.3 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II type 1a (AT-1a) receptor	359 aa	306 aa	21.9 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	404 aa	19.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	399 aa	25.3 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	348 aa	26.4 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	364 aa	23.1 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	325 aa	20.9 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	356 aa	22.2 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	307 aa	22.5 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	355 aa	23.9 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	404 aa	19.6 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	341 aa	23.2 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	306 aa	25.8 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	317 aa	24.6 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	328 aa	20.7 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	303 aa	25.4 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	296 aa	23.0 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	299 aa	25.1 %
Brugia malayi	GnHR receptor homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	364 aa	20.3 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	346 aa	18.2 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	335 aa	23.0 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	308 aa	27.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0248	0.0702	0.0702
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0032	1
Brugia malayi	Serotonin receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0025	0.0046	0.0046
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0128	0.0349	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0248	0.0702	0.0702
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0031	0.9377
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0016	0.0016
Brugia malayi	G-protein coupled receptor	0.0015	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0024	0.0018
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.0311	0.8837
Brugia malayi	putative neuropeptide receptor NPR1	0.0015	0.0016	0.0016
Brugia malayi	Thioredoxin reductase	0.005	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.3411	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0024	0.0663
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0032	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0024	0.0024
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0046	0.3795
Schistosoma mansoni	growth hormone secretagogue receptor	0.0015	0.0016	0.0016
Brugia malayi	G-protein coupled receptor	0.0015	0.0016	0.0016
Plasmodium falciparum	amino acid transporter, putative	0.0025	0.0046	0.3795
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0024	0.0018
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Echinococcus granulosus	neuropeptide FF receptor 2	0.0015	0.0016	0.0016
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0039	0.0039
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0017	0.0024	0.0018
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	neuropeptide F receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0016	0.0016
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.3411	1	1
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0014	0.0007
Echinococcus granulosus	sex peptide receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0016	0.0016
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0032	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0015	0.0016	0.0016
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	dro:myosuppressin receptor	0.0015	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Schistosoma mansoni	amine GPCR	0.0015	0.0016	0.0016
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0066	0.0066
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	sodium/chloride dependent transporter	0.0025	0.0046	0.0046
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0024	0.0018
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0016	0.0016
Echinococcus multilocularis	G protein coupled receptor 139	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0066	0.0066
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0025	0.0046	0.0046
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0016	0.0016
Trypanosoma brucei	unspecified product	0.002	0.0032	0.0027
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0063	0.0063
Loa Loa (eye worm)	glutathione reductase	0.005	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	neuropeptide f receptor 76f	0.0015	0.0016	0.0016
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0046	0.0046
Echinococcus multilocularis	neuropeptide s receptor	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.0311	0.8837
Onchocerca volvulus		0.0025	0.0046	0.003
Brugia malayi	RE15519p	0.0015	0.0016	0.0016
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0031	0.0026
Echinococcus granulosus	serotonin transporter	0.0147	0.0404	0.0404
Echinococcus granulosus	sodium and chloride dependent glycine	0.0025	0.0046	0.0046
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0031	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0121	0.0121
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0025	0.0046	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0016	0.0016
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0032	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0015	0.0017	0.1388
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0121	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0016	0.0016
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0025	0.0046	0.0046
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0031	0.8137
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0046	0.3795
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.0311	0.8837
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0016	0.0016
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0024	0.0018
Echinococcus multilocularis	somatostatin receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0039	0.0039
Brugia malayi	follicle stimulating hormone receptor	0.0256	0.0725	0.0725
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0121	0.0126
Schistosoma mansoni	DNA polymerase eta	0.002	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0032	0.0027
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Plasmodium vivax	SET domain protein, putative	0.0032	0.0066	0.4732
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0066	0.0066
Echinococcus multilocularis	orexin receptor type 2	0.0015	0.0016	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0024	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0016	0.0016
Plasmodium vivax	glutathione reductase, putative	0.005	0.0121	1
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0032	0.0032
Toxoplasma gondii	hypothetical protein	0.0025	0.0046	0.3795
Brugia malayi	hypothetical protein	0.0248	0.0702	0.0702
Echinococcus multilocularis	sex peptide receptor	0.0015	0.0016	0.0016
Giardia lamblia	DINP protein human, muc B family	0.002	0.0032	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0015	0.0016	0.0016
Echinococcus granulosus	dna polymerase eta	0.002	0.0032	0.0032
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0046	0.0046
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0147	0.0404	0.0404
Echinococcus granulosus	tm gpcr rhodopsin	0.0556	0.1608	0.1608
Schistosoma mansoni	histamine h1 receptor	0.0015	0.0016	0.0016
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0046	0.0046
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0015	0.0016	0.0016
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0066	0.0066
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0031	0.0031
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0032	0.0344
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0031	0.0323
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0016	0.0016
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0024	0.1999
Schistosoma mansoni	hypothetical protein	0.0359	0.1027	0.1027
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0039	0.0039
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0031	0.0031
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0031	0.0031
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0016	0.0016
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0024	0.0018
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.0311	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0147	0.0404	0.0404
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0046	0.3795
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0015	0.0016	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Schistosoma mansoni	amine GPCR	0.0015	0.0016	0.0016
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0025	0.0046	0.0046
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0016	0.0016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0016	0.0016
Treponema pallidum	sodium- and chloride- dependent transporter	0.0147	0.0404	1
Trypanosoma brucei	trypanothione reductase	0.005	0.0121	0.0126
Echinococcus multilocularis	serotonin receptor	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0032	0.0251
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	vesicular acetylcholine transporter	0.3411	1	1
Brugia malayi	Pre-SET motif family protein	0.0222	0.0625	0.0625
Echinococcus granulosus	serotonin receptor	0.0015	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	amine GPCR	0.0015	0.0016	0.0016
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0015	0.0016	0.0016
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0031	0.0175
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0025	0.0046	0.0046
Plasmodium falciparum	transporter, putative	0.0025	0.0046	0.3795
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0122	0.0122
Plasmodium falciparum	glutathione reductase	0.0017	0.0024	0.1999
Echinococcus granulosus	dna polymerase kappa	0.002	0.0032	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0031	0.0026
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0016	0.0016
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0039	0.0433
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0016	0.0016
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0031	0.2546
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	Pre-SET motif family protein	0.0032	0.0066	0.0066
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	larval opioid receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	ap endonuclease	0.002	0.0031	0.0031
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0025	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	Probable reductase	0.0115	0.0311	0.8837
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	allatostatin A receptor	0.0015	0.0016	0.0016
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0024	0.0018
Echinococcus granulosus	geminin	0.0359	0.1027	0.1027
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0256	0.0725	0.0725
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0015	0.0016	0.0016
Trichomonas vaginalis	DNA helicase recq1, putative	0.0022	0.0039	0.0433
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0014	0.0007
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0032	0.0032
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0025	0.0046	0.0046
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0031	0.9531
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	amine GPCR	0.0015	0.0016	0.0016
Echinococcus granulosus	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0015	0.0016	0.0016
Echinococcus granulosus	neuropeptide receptor A26	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Loa Loa (eye worm)	serotonin transporter b	0.0147	0.0404	0.0404
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0032	0.0027
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.0121	0.2985
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0032	0.0032
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	Probable oxidoreductase	0.0128	0.0349	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0014	0.0007
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Echinococcus granulosus	orexin receptor type 2	0.0015	0.0016	0.0016
Loa Loa (eye worm)	melatonin receptor type 1A	0.0015	0.0016	0.0016
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0032	0.0032
Toxoplasma gondii	thioredoxin reductase	0.005	0.0121	1
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0039	0.0039
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0032	0.0027
Plasmodium falciparum	thioredoxin reductase	0.005	0.0121	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0404	0.0404
Echinococcus granulosus	g-protein coupled receptor	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.0311	0.8837
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0024	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0025	0.0046	0.0046
Brugia malayi	Melatonin receptor type 1A	0.0015	0.0016	0.0016
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0556	0.1608	0.1608
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0024	0.7483
Brugia malayi	Dopamine receptor protein 1	0.0015	0.0016	0.0016
Schistosoma mansoni	myosin xvIII	0.0015	0.0016	0.0016
Plasmodium vivax	amine transporter, putative	0.0025	0.0046	0.2759
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0128	0.0349	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0025	0.0046	0.0046
Echinococcus multilocularis	neuropeptide receptor A26	0.0015	0.0016	0.0016
Echinococcus multilocularis	vesicular acetylcholine transporter	0.3411	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0024	0.0018
Echinococcus multilocularis	geminin	0.0359	0.1027	0.1027
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0024	0.0024
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Trypanosoma brucei	C-8 sterol isomerase, putative	0.3056	0.8955	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0066	0.5486
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0032	0.0027
Brugia malayi	G protein-coupled receptor	0.0015	0.0016	0.0016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0024	0.0018
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0046	0.0046
Leishmania major	trypanothione reductase	0.005	0.0121	0.0126
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0032	0.0032
Onchocerca volvulus		0.0253	0.0716	0.0701
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0046	0.0046
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0066	0.0066
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0031	0.2531
Schistosoma mansoni	opsin-like receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0015	0.0016	0.0016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0147	0.0404	0.0404
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0046	0.0046
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0025	0.0046	0.0046
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0024	0.1999
Loa Loa (eye worm)	TYRA-2 protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0066	0.0066
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	amine GPCR	0.0015	0.0016	0.0016
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0031	0.1301
Toxoplasma gondii	hypothetical protein	0.0025	0.0046	0.3795
Schistosoma mansoni	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0015	0.0016	0.0016
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0011	0.0011
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	norepinephrine transporter	0.0147	0.0404	0.0404
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Leishmania major	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Echinococcus granulosus	neuropeptide s receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0016	0.0016
Brugia malayi	Dopamine receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.3056	0.8955	0.8955
Onchocerca volvulus		0.0025	0.0046	0.003
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0015	0.0016	0.0016
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0024	0.0018
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0031	0.0031
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0015	0.0016	0.0016
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0031	1
Onchocerca volvulus		0.0147	0.0404	0.0389
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0122	0.0122
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0051	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0024	0.0229
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0015	0.0016	0.0016
Onchocerca volvulus		0.0025	0.0046	0.003
Echinococcus granulosus	7TM GPCR rhodopsin	0.0015	0.0016	0.0016
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0015	0.0016	0.0016
Echinococcus multilocularis	serotonin receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	sodium and chloride dependent glycine	0.0025	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	somatostatin receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0032	0.0032
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0024	0.1999
Schistosoma mansoni	ap endonuclease	0.002	0.0031	0.0031
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0046	0.0046
Trypanosoma brucei	unspecified product	0.0014	0.0014	0.0007
Toxoplasma gondii	exonuclease III APE	0.002	0.0031	0.2546
Schistosoma mansoni	adenoreceptor	0.0015	0.0016	0.0016
Schistosoma mansoni	opsin-like receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0025	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	g-protein coupled receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0046	0.0046
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0025	0.0046	0.0046
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0016	0.0016
Trypanosoma brucei	unspecified product	0.0014	0.0014	0.0007
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0011	0.0011
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0015	0.0016	0.0016
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0032	0.0251
Brugia malayi	neuropeptide F receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0015	0.0016	0.0016
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0032
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0024	0.0024
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0016	0.0016
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0032	0.0344
Onchocerca volvulus		0.0032	0.0066	0.0051
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0066	0.0066
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0031	0.0026
Echinococcus multilocularis	dna polymerase eta	0.002	0.0032	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Brugia malayi	Dopamine receptor protein 2	0.0015	0.0016	0.0016
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0025	0.0046	0.0046
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0359	0.1027	0.1027
Schistosoma mansoni	sodium/chloride dependent transporter	0.0147	0.0404	0.0404
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0024	0.0024
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0024	0.1999
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0024	0.1999
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0032	0.0027
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0024	0.0018
Brugia malayi	G protein-coupled receptor F59B2.13	0.0015	0.0016	0.0016
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0025	0.0046	0.0046
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	G protein coupled receptor 139	0.0015	0.0016	0.0016
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0015	0.0016	0.0016
Brugia malayi	Serotonin receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0032	0.0032
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0024	0.0018
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0032	0.0027
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0024	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0025	0.0046	0.0046
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0024	0.0229
Echinococcus granulosus	vesicular acetylcholine transporter	0.3411	1	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0066	0.0066
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0015	0.0016	0.0016
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	putative neuropeptide receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0404	0.0404
Brugia malayi	hypothetical protein	0.0015	0.0016	0.0016
Brugia malayi	ORL1-like opioid receptor	0.0015	0.0016	0.0016
Onchocerca volvulus		0.0051	0.0122	0.0106
Loa Loa (eye worm)	hypothetical protein	0.1562	0.4564	0.4564
Brugia malayi	glutathione reductase	0.005	0.0121	0.0121
Echinococcus granulosus	allatostatin A receptor	0.0015	0.0016	0.0016
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0017	0.0024	0.0018
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0015	0.0016	0.0016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0031	0.0026
Plasmodium falciparum	glutathione reductase	0.005	0.0121	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus granulosus	fmrfamide receptor	0.0015	0.0016	0.0016
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0404	0.0404
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0015	0.0016	0.0016
Brugia malayi	sulfakinin receptor protein	0.0015	0.0016	0.0016
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0015	0.0016	0.0016
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0016	0.0016
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0015	0.0016	0.0016
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0025	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0016	0.0016
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.3056	0.8955	0.8955
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0016	0.0016
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0024	0.0663
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0031	0.0323
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0016	0.0016
Leishmania major	C-8 sterol isomerase-like protein	0.3056	0.8955	1
Brugia malayi	AKH receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.0625	0.0625
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0121	0.0121
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0015	0.0016	0.0016
Leishmania major	DNA polymerase eta, putative	0.002	0.0032	0.0027
Echinococcus granulosus	survival motor neuron protein 1	0.0248	0.0702	0.0702
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0024	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0025	0.0046	0.0046
Brugia malayi	GnHR receptor homolog	0.0015	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	serotonin transporter	0.0147	0.0404	0.0404
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.0716	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0015	0.0016	0.0016
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	opsin-like receptor	0.0015	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0016
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0015	0.0016	0.0016
Echinococcus multilocularis	dro:myosuppressin receptor	0.0015	0.0016	0.0016
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0128	0.0349	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0025	0.0046	0.0046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0016	0.0016
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0016	0.0016
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0046	0.2759
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.3056	0.8955	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 76 nM	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	ChEMBL.	8246227
IC50 (functional)	= 76 nM	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	ChEMBL.	8246227

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 209153