Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0052 | 0.0295 | 0.0337 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0035 | 0.0137 | 0.5 |
Schistosoma mansoni | camp-dependent rap1 guanine-nucleotide exchange factor | 0.0035 | 0.0137 | 0.0558 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0143 | 0.0164 |
Echinococcus multilocularis | serotonin transporter | 0.0061 | 0.0375 | 0.0428 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.8763 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0061 | 0.0375 | 0.153 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0375 | 0.0375 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0061 | 0.0375 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0035 | 0.0137 | 0.0156 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0096 | 0.0698 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.1115 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0143 | 0.0643 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0076 | 0.0517 | 0.059 |
Trypanosoma cruzi | cAMP binding protein, putative | 0.0035 | 0.0137 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0052 | 0.0295 | 0.1258 |
Leishmania major | regulatory subunit of protein kinase a-like protein | 0.0035 | 0.0137 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0137 | 0.0477 |
Trypanosoma brucei | cAMP binding protein, putative | 0.0035 | 0.0137 | 1 |
Schistosoma mansoni | camp-dependent protein kinase regulatory chain | 0.0035 | 0.0137 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0295 | 0.0295 |
Toxoplasma gondii | hypothetical protein | 0.1115 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1115 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0264 | 0.2229 | 1 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0035 | 0.0137 | 0.0558 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0238 | 0.1996 | 0.8955 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0035 | 0.0137 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0264 | 0.2229 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0035 | 0.0137 | 0.0614 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0137 | 0.5 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0087 | 0.0355 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0087 | 0.0355 |
Chlamydia trachomatis | cAMP-dependent protein kinase regulatory subunit | 0.0035 | 0.0137 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0076 | 0.0517 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0087 | 0.0087 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0035 | 0.0137 | 0.0558 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0035 | 0.0137 | 0.0558 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0052 | 0.0295 | 0.1205 |
Plasmodium vivax | rap guanine nucleotide exchange factor, putative | 0.0035 | 0.0137 | 1 |
Leishmania major | hypothetical protein, unknown function | 0.0035 | 0.0137 | 0.5 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.0035 | 0.0137 | 0.0614 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0035 | 0.0137 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0087 | 0.039 |
Trypanosoma cruzi | cAMP response protein 1, putative | 0.0035 | 0.0137 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0056 | 0.0327 | 0.0373 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0042 | 0.0198 | 0.081 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1135 | 0.5094 |
Onchocerca volvulus | 0.0035 | 0.0137 | 0.3647 | |
Leishmania major | protein kinase, putative | 0.0035 | 0.0137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1911 | 0.1911 |
Schistosoma mansoni | camp-dependent protein kinase type II-alpha regulatory subunit | 0.0035 | 0.0137 | 0.0558 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0264 | 0.2229 | 0.2543 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0076 | 0.0517 | 0.2109 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0087 | 0.0099 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.0035 | 0.0137 | 0.0614 |
Trypanosoma brucei | protein kinase A regulatory subunit | 0.0035 | 0.0137 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1135 | 0.1135 |
Echinococcus granulosus | serotonin transporter | 0.0061 | 0.0375 | 0.1682 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0035 | 0.0137 | 0.0614 |
Loa Loa (eye worm) | serotonin transporter b | 0.0061 | 0.0375 | 0.0375 |
Brugia malayi | jmjC domain containing protein | 0.0096 | 0.0698 | 0.313 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0052 | 0.0295 | 0.0337 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0052 | 0.0295 | 0.1325 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1135 | 0.1135 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0096 | 0.0698 | 0.313 |
Leishmania major | protein kinase, putative | 0.0035 | 0.0137 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0373 | 0.0373 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0052 | 0.0295 | 0.1325 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1115 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0137 | 0.5 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0052 | 0.0295 | 0.0337 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0035 | 0.0137 | 0.0558 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0035 | 0.0137 | 0.005 |
Leishmania major | cyclic nucleotide-binding protein-like protein | 0.0035 | 0.0137 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0288 | 0.245 | 1 |
Trypanosoma cruzi | regulatory subunit of protein kinase a-like protein, putative | 0.0035 | 0.0137 | 0.5 |
Brugia malayi | cAMP-dependent protein kinase regulatory chain, putative | 0.0035 | 0.0137 | 0.0614 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0052 | 0.0295 | 0.0337 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0052 | 0.0295 | 0.0337 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0052 | 0.0295 | 0.1325 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0052 | 0.0295 | 0.1325 |
Plasmodium falciparum | cGMP-dependent protein kinase | 0.0035 | 0.0137 | 1 |
Trypanosoma cruzi | protein kinase A regulatory subunit | 0.0035 | 0.0137 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0087 | 0.0087 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0137 | 0.5 |
Echinococcus granulosus | cAMP dependent protein kinase regulatory | 0.0035 | 0.0137 | 0.0614 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0263 | 0.1178 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0052 | 0.0295 | 0.1325 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0061 | 0.0375 | 0.0375 |
Trichomonas vaginalis | cAMP-dependent protein kinase regulatory subunit, putative | 0.0035 | 0.0137 | 0.0477 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0035 | 0.0137 | 0.3647 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0143 | 0.0643 |
Echinococcus granulosus | cAMP dependent protein kinase type II regulatory | 0.0035 | 0.0137 | 0.0614 |
Mycobacterium ulcerans | regulatory protein | 0.0035 | 0.0137 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0076 | 0.0517 | 0.2319 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0137 | 0.0477 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0035 | 0.0137 | 0.0558 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0087 | 0.039 |
Onchocerca volvulus | 0.0049 | 0.0263 | 0.7003 | |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0035 | 0.0137 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0375 | 0.0375 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0061 | 0.0375 | 0.153 |
Toxoplasma gondii | cAMP-dependent protein kinase regulatory subunit | 0.0035 | 0.0137 | 0.005 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.0035 | 0.0137 | 0.0614 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0035 | 0.0137 | 0.0156 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.0035 | 0.0137 | 0.005 |
Echinococcus multilocularis | cAMP dependent protein kinase type II regulatory | 0.0035 | 0.0137 | 0.0156 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0035 | 0.0137 | 0.0558 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0263 | 0.1072 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0137 | 0.5 |
Brugia malayi | Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog | 0.0035 | 0.0137 | 0.0614 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0052 | 0.0295 | 0.1205 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0052 | 0.0295 | 0.1325 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0035 | 0.0137 | 0.0614 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0035 | 0.0137 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0052 | 0.0295 | 0.1205 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0024 | 0.004 | 0.0179 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0035 | 0.0137 | 0.0614 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0076 | 0.0517 | 0.2109 |
Loa Loa (eye worm) | cAMP-dependent protein kinase regulatory subunit | 0.0035 | 0.0137 | 0.0137 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0087 | 0.6355 |
Brugia malayi | hypothetical protein | 0.0238 | 0.1996 | 0.8955 |
Brugia malayi | Egg laying defective protein 4 | 0.0035 | 0.0137 | 0.0614 |
Schistosoma mansoni | lipoxygenase | 0.0056 | 0.0327 | 0.1334 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0137 | 0.0477 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein Cmr | 0.0035 | 0.0137 | 0.5 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0035 | 0.0137 | 0.005 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0052 | 0.0295 | 0.1205 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0288 | 0.245 | 1 |
Giardia lamblia | CAMP-dependent protein kinase regulatory chain | 0.0035 | 0.0137 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0035 | 0.0137 | 1 |
Echinococcus multilocularis | peregrin | 0.0029 | 0.0087 | 0.0099 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0238 | 0.1996 | 0.2278 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.004 | 0.0163 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0056 | 0.0327 | 0.1466 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0087 | 0.039 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0052 | 0.0295 | 0.1205 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0052 | 0.0295 | 0.0295 |
Mycobacterium ulcerans | transmembrane transport protein | 0.0035 | 0.0137 | 0.5 |
Trypanosoma cruzi | cAMP response protein 1 | 0.0035 | 0.0137 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0192 | 0.0219 |
Trypanosoma brucei | cAMP response protein 1, putative | 0.0035 | 0.0137 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.0517 | 0.211 |
Leishmania major | protein kinase A regulatory subunit, putative | 0.0035 | 0.0137 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0061 | 0.0375 | 0.0375 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0.0087 | 0.2318 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0052 | 0.0295 | 0.1325 |
Trypanosoma brucei | cyclic nucleotide-binding domain containing protein, putative | 0.0035 | 0.0137 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase regulatory | 0.0035 | 0.0137 | 0.0156 |
Schistosoma mansoni | cyclic nucleotide-gated ion channel | 0.0035 | 0.0137 | 0.0558 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.0198 | 0.081 |
Echinococcus multilocularis | patatin phospholipase domain containing protein | 0.0035 | 0.0137 | 0.0156 |
Trypanosoma brucei | Flagellar Member 6 | 0.0035 | 0.0137 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0137 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0137 | 0.3647 | |
Trypanosoma cruzi | regulatory subunit of protein kinase a-like protein, putative | 0.0035 | 0.0137 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0264 | 0.2229 | 0.2229 |
Echinococcus granulosus | peregrin | 0.0029 | 0.0087 | 0.039 |
Schistosoma mansoni | camp-dependent protein kinase type II regulatory subunit | 0.0035 | 0.0137 | 0.0558 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0517 | 0.0517 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0137 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0035 | 0.0137 | 0.0558 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0263 | 0.1072 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0052 | 0.0295 | 0.1205 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0143 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0137 | 0.0137 |
Onchocerca volvulus | 0.0061 | 0.0375 | 1 | |
Plasmodium falciparum | cAMP-dependent protein kinase regulatory subunit | 0.0035 | 0.0137 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0137 | 0.5 |
Trypanosoma brucei | cyclic nucleotide-binding domain containing protein, putative | 0.0035 | 0.0137 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0143 | 0.0143 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0137 | 0.5 |
Trichomonas vaginalis | cAMP-dependent protein kinase type I-beta regulatory subunit, putative | 0.0035 | 0.0137 | 0.0477 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0061 | 0.0375 | 0.1682 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0035 | 0.0137 | 0.005 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0035 | 0.0137 | 0.0558 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0247 | 0.207 | 1 |
Trypanosoma cruzi | Flagellar Member 6 | 0.0035 | 0.0137 | 0.5 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0035 | 0.0137 | 0.0558 |
Trypanosoma cruzi | cyclic nucleotide-binding domain containing protein, putative | 0.0035 | 0.0137 | 0.5 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0035 | 0.0137 | 0.0156 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0076 | 0.0517 | 0.059 |
Echinococcus multilocularis | expressed conserved protein | 0.0035 | 0.0137 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1996 | 0.1996 |
Echinococcus granulosus | voltage gated potassium channel | 0.0076 | 0.0517 | 0.2319 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.0035 | 0.0137 | 0.0137 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0052 | 0.0295 | 0.1258 |
Echinococcus multilocularis | cAMP dependent protein kinase type I beta | 0.0035 | 0.0137 | 0.0156 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0247 | 0.207 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0143 | 0.0585 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0192 | 0.0862 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0087 | 0.6355 |
Echinococcus granulosus | cAMP dependent protein kinase type I beta | 0.0035 | 0.0137 | 0.0614 |
Toxoplasma gondii | cyclic nucleotide-binding domain-containing protein | 0.0035 | 0.0137 | 0.005 |
Schistosoma mansoni | similar to Protein C20orf152 homolog | 0.0035 | 0.0137 | 0.0558 |
Mycobacterium tuberculosis | Probable glutamine-transport ATP-binding protein ABC transporter GlnQ | 0.0035 | 0.0137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0052 | 0.0295 | 0.0295 |
Mycobacterium tuberculosis | Probable conserved transmembrane transport protein | 0.0035 | 0.0137 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0137 | 0.0558 |
Plasmodium vivax | CAMP-dependent protein kinase regulatory subunit, putative | 0.0035 | 0.0137 | 1 |
Echinococcus granulosus | single minded 2 | 0.0024 | 0.004 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0279 | 0.0279 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.