Detailed information for compound 2173833

Basic information

Technical information
  • TDR Targets ID: 2173833
  • Name: Galanin-1-30
  • MW: 3155.55 | Formula: C139H210N42O43
  • H donors: 47 H acceptors: 45 LogP: -15.93 Rotable bonds: 129
    Rule of 5 violations (Lipinski): 3
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CO)[C@H](O)C)CC(C)C)CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)CN)CC(C)C)CC(=O)N)CO)C)CC(C)C)CC(C)C)Cc1[nH]cnc1)C)Cc1[nH]cnc1)CCCNC(=N)N)CO)Cc1ccccc1)CO)CC(=O)O
  • InChi: InChI=1S/C139H210N42O43/c1-65(2)38-84(165-121(206)86(40-67(5)6)166-123(208)88(43-75-31-33-79(188)34-32-75)161-106(193)55-151-114(199)70(11)157-131(216)97(59-182)175-127(212)95(49-104(144)191)170-122(207)87(41-68(7)8)173-136(221)112(72(13)186)180-130(215)90(159-105(192)51-141)44-76-52-150-81-27-19-18-26-80(76)81)116(201)154-58-109(196)181-37-23-30-101(181)134(219)172-91(45-77-53-147-63-155-77)120(205)158-71(12)115(200)178-111(69(9)10)135(220)153-57-108(195)162-94(48-103(143)190)126(211)168-92(46-78-54-148-64-156-78)125(210)164-83(29-22-36-149-139(145)146)119(204)174-98(60-183)132(217)167-89(42-74-24-16-15-17-25-74)124(209)176-99(61-184)133(218)171-96(50-110(197)198)128(213)163-82(28-20-21-35-140)118(203)169-93(47-102(142)189)117(202)152-56-107(194)160-85(39-66(3)4)129(214)179-113(73(14)187)137(222)177-100(62-185)138(223)224/h15-19,24-27,31-34,52-54,63-73,82-101,111-113,150,182-188H,20-23,28-30,35-51,55-62,140-141H2,1-14H3,(H2,142,189)(H2,143,190)(H2,144,191)(H,147,155)(H,148,156)(H,151,199)(H,152,202)(H,153,220)(H,154,201)(H,157,216)(H,158,205)(H,159,192)(H,160,194)(H,161,193)(H,162,195)(H,163,213)(H,164,210)(H,165,206)(H,166,208)(H,167,217)(H,168,211)(H,169,203)(H,170,207)(H,171,218)(H,172,219)(H,173,221)(H,174,204)(H,175,212)(H,176,209)(H,177,222)(H,178,200)(H,179,214)(H,180,215)(H,197,198)(H,223,224)(H4,145,146,149)/t70-,71-,72+,73+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-/m0/s1
  • InChiKey: CBSXZYWGVAQSHI-RUKUCZSXSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens galanin receptor 1 References
Homo sapiens galanin receptor 2 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04233 galanin receptor, invertebrate, putative Get druggable targets OG5_128775 All targets in OG5_128775
Echinococcus multilocularis allatostatin A receptor Get druggable targets OG5_128775 All targets in OG5_128775
Schistosoma mansoni peptide (allatostatin)-like receptor Get druggable targets OG5_128775 All targets in OG5_128775
Echinococcus granulosus allatostatin A receptor Get druggable targets OG5_128775 All targets in OG5_128775
Onchocerca volvulus Get druggable targets OG5_128775 All targets in OG5_128775
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128775 All targets in OG5_128775

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor galanin receptor 1 349 aa 381 aa 20.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0057 0.1063
Echinococcus multilocularis chromobox protein 1 0.0077 0.0134 0.0233
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0015 0.0281
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0595 0.1217 0.2098
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0134 0.2519
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0079 0.0137
Schistosoma mansoni cpg binding protein 0.0036 0.0048 0.0308
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0086 0.0149
Mycobacterium ulcerans beta-lactamase 0.004 0.0057 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0008 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0037 0.0702
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.0465 0.0465
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0057 0.0057
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0008 0.0014
Schistosoma mansoni choline o-acyltransferase 0.0595 0.1217 0.7784
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0014 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0079 0.0137
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0079 0.0079
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0011 0.0019
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0942 0.194 0.3367
Schistosoma mansoni hypothetical protein 0.0187 0.0364 0.2329
Brugia malayi Bromodomain containing protein 0.0086 0.0154 0.0154
Echinococcus granulosus dnaJ subfamily B 0.0451 0.0916 0.1589
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0015 0.0281
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0 0.5
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.007
Mycobacterium ulcerans hypothetical protein 0.004 0.0057 0.5
Leishmania major carnitine/choline acetyltransferase, putative 0.0595 0.1217 0.2098
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0134 0.2519
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.007
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.004 0.0057 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0072 0.0459
Plasmodium vivax SET domain protein, putative 0.0034 0.0045 0.8022
Loa Loa (eye worm) hypothetical protein 0.008 0.014 0.014
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0057 0.5
Schistosoma mansoni hypothetical protein 0.0187 0.0364 0.2329
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0015 0.0281
Onchocerca volvulus 0.0047 0.0072 0.0589
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0045 0.424
Trypanosoma cruzi hypothetical protein, conserved 0.0595 0.1217 0.2098
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0011 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0064 0.1195
Trichomonas vaginalis set domain proteins, putative 0.0268 0.0533 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0057
Schistosoma mansoni microtubule-associated protein tau 0.0761 0.1563 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.004 0.004
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0054 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0595 0.1217 0.6253
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0091 0.0091
Brugia malayi CHD4 protein 0.0017 0.0008 0.0008
Schistosoma mansoni chromobox protein 0.0077 0.0134 0.0859
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0079 0.0079
Echinococcus multilocularis zinc finger protein 0.0024 0.0024 0.0041
Brugia malayi MH2 domain containing protein 0.0135 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0057
Mycobacterium leprae Probable lipase LipE 0.004 0.0057 0.5
Echinococcus granulosus Chromobox protein 3 0.0013 0.0000000029442 0.0000000051085
Brugia malayi PHD-finger family protein 0.003 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0046 0.007 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0057 0.0362
Echinococcus granulosus GPCR family 2 0.0018 0.0011 0.0019
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0143
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0031 0.0053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0057 0.5
Echinococcus multilocularis geminin 0.0187 0.0364 0.0632
Echinococcus granulosus chromobox protein 1 0.0077 0.0134 0.0233
Echinococcus multilocularis microtubule associated protein 2 0.0761 0.1563 0.2713
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0086 0.0149
Onchocerca volvulus 0.0595 0.1217 1
Brugia malayi beta-lactamase family protein 0.004 0.0057 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0079 0.0137
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0071 0.058
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0595 0.1217 0.2098
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0011 0.0011
Echinococcus granulosus allatostatin A receptor 0.0177 0.0343 0.0596
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0041 0.0072
Echinococcus multilocularis chromobox protein 1 0.0077 0.0134 0.0233
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0015 0.0281
Loa Loa (eye worm) hypothetical protein 0.0056 0.0091 0.0091
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0942 0.194 0.3367
Loa Loa (eye worm) hypothetical protein 0.0054 0.0086 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0071 0.1323
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0118 0.0205
Onchocerca volvulus 0.0034 0.0044 0.0364
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0595 0.1217 0.2098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0086 0.0548
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0013 0 0.5
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0942 0.194 0.194
Mycobacterium leprae conserved hypothetical protein 0.004 0.0057 0.5
Schistosoma mansoni cpg binding protein 0.0032 0.004 0.0255
Leishmania major carnitine palmitoyltransferase-like protein 0.0942 0.194 0.3356
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0057 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0079 0.0506
Plasmodium vivax hypothetical protein, conserved 0.004 0.0057 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0058 0.0101
Brugia malayi chromobox protein homolog 3 0.0043 0.0064 0.0064
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0031 0.0053
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0015 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0011 0.0019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0118 0.0205
Brugia malayi Pre-SET motif family protein 0.0235 0.0465 0.0465
Schistosoma mansoni cpg binding protein 0.0036 0.0048 0.0308
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0134 0.0134
Onchocerca volvulus 0.0595 0.1217 1
Mycobacterium ulcerans lipase LipD 0.004 0.0057 0.5
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0057 0.0098
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0057 0.0243
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0071 0.1323
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0595 0.1217 0.6253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0057 0.0362
Onchocerca volvulus 0.0268 0.0533 0.4379
Schistosoma mansoni chromobox protein 0.0077 0.0134 0.0859
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0057
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0091 0.0091
Toxoplasma gondii ABC1 family protein 0.004 0.0057 0.5285
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0595 0.1217 0.1217
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0001 0.0001
Onchocerca volvulus 0.0595 0.1217 1
Echinococcus multilocularis cpg binding protein 0.0036 0.0048 0.0084
Brugia malayi beta-lactamase 0.004 0.0057 0.0057
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0014 0.0024
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0 0.5
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0942 0.194 0.194
Brugia malayi Choline O-acetyltransferase 0.0595 0.1217 0.1217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0086 0.0548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0015 0.0281
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0014 0.0089
Entamoeba histolytica hypothetical protein 0.0013 0 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.0504 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0011 0.0019
Schistosoma mansoni hypothetical protein 0.0038 0.0054 0.0345
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0015 0.0281
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0595 0.1217 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0064 0.1195
Brugia malayi Pre-SET motif family protein 0.0034 0.0045 0.0045
Onchocerca volvulus 0.004 0.0057 0.0466
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0031 0.0196
Schistosoma mansoni zinc finger protein 0.0017 0.001 0.0062
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0011 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0015 0.0281
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0064 0.0064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0057 0.0057
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0942 0.194 1
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.2772 0.5763 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.0343 0.0343
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.2772 0.5763 1
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.007
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0044
Echinococcus granulosus microtubule associated protein 2 0.0761 0.1563 0.2713
Echinococcus granulosus cpg binding protein 0.0036 0.0048 0.0084
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0008 0.0053
Loa Loa (eye worm) hypothetical protein 0.0043 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0079 0.0506
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0942 0.194 0.3356
Echinococcus granulosus zinc finger protein 0.0024 0.0024 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0079 0.0506
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0138 0.0262 0.0262
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0595 0.1217 0.6253
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.2772 0.5763 1
Trypanosoma cruzi hypothetical protein, conserved 0.0595 0.1217 0.2098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0107 1
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.2772 0.5763 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0091 0.0091
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0595 0.1217 0.6253
Onchocerca volvulus 0.0595 0.1217 1
Trypanosoma cruzi hypothetical protein, conserved 0.0595 0.1217 0.2098
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0057 0.1063
Onchocerca volvulus 0.0177 0.0343 0.282
Trypanosoma cruzi hypothetical protein, conserved 0.0595 0.1217 0.2098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0045 0.0291
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0117 0.0746
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0595 0.1217 0.2098
Onchocerca volvulus 0.0032 0.004 0.0328
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0064 0.0523
Schistosoma mansoni bromodomain containing protein 0.0073 0.0127 0.0809
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0008 0.0151
Brugia malayi Bromodomain containing protein 0.0043 0.0064 0.0064
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0079 0.0137
Brugia malayi Heterochromatin protein 1 0.0077 0.0134 0.0134
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0015 0.0281
Schistosoma mansoni zinc finger protein 0.0024 0.0024 0.0151
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0595 0.1217 0.2098
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0014 0.0089
Brugia malayi SET domain containing protein 0.0015 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0057 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0007 0.013
Echinococcus granulosus chromobox protein 1 0.0077 0.0134 0.0233
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0255 0.0255
Entamoeba histolytica hypothetical protein 0.0013 0 0.5
Onchocerca volvulus 0.0013 0.0000000029442 0.00000002419
Onchocerca volvulus 0.004 0.0057 0.0466
Onchocerca volvulus 0.004 0.0057 0.0466
Loa Loa (eye worm) hypothetical protein 0.0595 0.1217 0.1217
Loa Loa (eye worm) hypothetical protein 0.005 0.0078 0.0078
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0058 0.0101
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0057 0.1063
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0037 0.0702
Trichomonas vaginalis esterase, putative 0.004 0.0057 0.1063
Loa Loa (eye worm) beta-lactamase 0.004 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0057
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0000000029442 0.0000000051085
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.2772 0.5763 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0177 0.0343 0.2195
Onchocerca volvulus Huntingtin homolog 0.0138 0.0262 0.2154
Echinococcus multilocularis GPCR, family 2 0.0018 0.0011 0.0019
Echinococcus granulosus geminin 0.0187 0.0364 0.0632
Leishmania major hypothetical protein, conserved 0.004 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0138 0.0262 0.0262
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0255 0.0255
Echinococcus multilocularis choline O acetyltransferase 0.0595 0.1217 0.2112
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.0916 0.1589
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0045 0.0079
Schistosoma mansoni hypothetical protein 0.0451 0.0916 0.5859
Schistosoma mansoni choline o-acyltransferase 0.0595 0.1217 0.7784
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0057 0.1063
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0008 0.0014
Plasmodium falciparum heterochromatin protein 1 0.0013 0 0.5
Brugia malayi hypothetical protein 0.0138 0.0262 0.0262
Echinococcus granulosus choline O acetyltransferase 0.0595 0.1217 0.2112
Schistosoma mansoni hypothetical protein 0.0017 0.001 0.0062
Onchocerca volvulus Huntingtin homolog 0.0138 0.0262 0.2154
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0011 0.0011
Brugia malayi Choline O-acetyltransferase 0.0595 0.1217 0.1217
Trypanosoma cruzi hypothetical protein, conserved 0.0595 0.1217 0.2098
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0057 0.1063
Loa Loa (eye worm) choline O-acetyltransferase 0.0595 0.1217 0.1217
Echinococcus multilocularis allatostatin A receptor 0.0177 0.0343 0.0596
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0057 0.0098
Loa Loa (eye worm) hypothetical protein 0.4801 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.9 10'-11M Displacement of [125I]galanin from human recombinant GAL1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method LITERATURE. 27876250
IC50 (binding) = 2.6 10'-9M Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method LITERATURE. 27876250

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.