Detailed information for compound 2215829

Basic information

Technical information
  • TDR Targets ID: 2215829
  • Name: 5-[[(3S,4S)-4-(1,3-benzodioxol-5-ylmethyl)-2- (phenylmethoxy)oxolan-3-yl]methyl]-1,3-benzod ioxole
  • MW: 446.173 | Formula: C27H26O6
  • H donors: 0 H acceptors: 0 LogP: 5.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)COC1OC[C@H]([C@@H]1Cc1ccc2c(c1)OCO2)Cc1ccc2c(c1)OCO2
  • InChi: InChI=1S/C27H26O6/c1-2-4-18(5-3-1)14-28-27-22(11-20-7-9-24-26(13-20)33-17-31-24)21(15-29-27)10-19-6-8-23-25(12-19)32-16-30-23/h1-9,12-13,21-22,27H,10-11,14-17H2/t21-,22+,27?/m1/s1
  • InChiKey: XOAMOIWHAXNEGT-OCTGXNKJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[[(3S,4S)-4-(1,3-benzodioxol-5-ylmethyl)-2-(phenylmethoxy)tetrahydrofuran-3-yl]methyl]-1,3-benzodioxole
  • 5-[[(3S,4S)-4-(1,3-benzodioxol-5-ylmethyl)-2-(phenylmethoxy)-3-tetrahydrofuranyl]methyl]-1,3-benzodioxole
  • 5-[[(3S,4S)-4-(1,3-benzodioxol-5-ylmethyl)-2-(benzyloxy)tetrahydrofuran-3-yl]methyl]-1,3-benzodioxole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.012 0.2925 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0318 0.2057
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.2925 1
Brugia malayi GnHR receptor homolog 0.0037 0.0318 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Echinococcus granulosus g protein coupled receptor 0.0037 0.0318 0.2057
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0364 0.0364
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.2925 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0364 0.0364
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0318 0.2057
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0061 0.1072 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0061 0.1072 1
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0364 0.2435
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0623 0.0623
Echinococcus multilocularis tar DNA binding protein 0.0068 0.1287 1
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0623 0.4553
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0061 0.1072 0.3665
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.2925 1
Brugia malayi Cytochrome P450 family protein 0.0061 0.1072 0.1072
Brugia malayi Melatonin receptor type 1A 0.0037 0.0318 0.0318
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0061 0.1072 1
Schistosoma mansoni opsin-like receptor 0.0037 0.0318 0.2057
Echinococcus granulosus neuropeptide receptor 0.0037 0.0318 0.2057
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0318 0.2057
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0318 0.2057
Brugia malayi Cytochrome P450 family protein 0.0061 0.1072 0.1072
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0318 0.2057
Schistosoma mansoni amine GPCR 0.0037 0.0318 0.2057
Schistosoma mansoni amine GPCR 0.0037 0.0318 0.2057
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Trypanosoma brucei calpain, putative 0.012 0.2925 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0318 0.2057
Schistosoma mansoni opsin-like receptor 0.0037 0.0318 0.2057
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0061 0.1072 0.1081
Loa Loa (eye worm) hypothetical protein 0.0039 0.0364 0.0364
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0318 0.2057
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0061 0.1072 0.1081
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) TAR-binding protein 0.0068 0.1287 0.1287
Echinococcus granulosus tar DNA binding protein 0.0068 0.1287 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Mycobacterium leprae putative cytochrome p450 0.0061 0.1072 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0061 0.1072 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0318 0.2057
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0061 0.1072 1
Schistosoma mansoni hypothetical protein 0.0037 0.0318 0.2057
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0318 0.2057
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0364 0.5
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1287 1
Echinococcus multilocularis 0.0061 0.1072 0.8238
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0318 0.2057
Echinococcus granulosus g protein coupled receptor 0.0037 0.0318 0.2057
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus granulosus cytochrome P450 2K1 0.0061 0.1072 0.8238
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.0318 0.2057
Echinococcus multilocularis serotonin receptor 0.0037 0.0318 0.2057
Schistosoma mansoni biogenic amine receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0318 0.2057
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0318 0.2057
Trypanosoma brucei cytochrome P450, putative 0.0061 0.1072 0.3665
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0318 0.2057
Echinococcus multilocularis sex peptide receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0364 0.5
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) cytochrome P450 0.0061 0.1072 0.1072
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0061 0.1072 0.1081
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0061 0.1072 1
Brugia malayi TAR-binding protein 0.0068 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.0039 0.0364 0.0364
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0061 0.1072 0.1081
Brugia malayi beta-lactamase family protein 0.0039 0.0364 0.0364
Schistosoma mansoni biogenic amine receptor 0.0037 0.0318 0.2057
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0318 0.2057
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.2925 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0061 0.1072 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0061 0.1072 1
Brugia malayi Serotonin receptor 0.0037 0.0318 0.0318
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0061 0.1072 0.1081
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0061 0.1072 0.1081
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0318 0.2057
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0061 0.1072 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0318 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0318 0.2057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0364 0.2435
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0061 0.1072 0.3665
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0318 0.2057
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.1072 0.1072
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0061 0.1072 0.1081
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0061 0.1072 0.1081
Brugia malayi Dopamine receptor 0.0037 0.0318 0.0318
Echinococcus granulosus allatostatin A receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis somatostatin receptor 0.0037 0.0318 0.2057
Schistosoma mansoni neuropeptide receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0364 0.0364
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus granulosus fmrfamide receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0318 0.2057
Brugia malayi Dopamine receptor protein 1 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0318 0.2057
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0061 0.1072 0.1081
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0318 0.0318
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0318 0.2057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0318 0.2057
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0318 0.2057
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni neuropeptide receptor 0.0037 0.0318 0.2057
Echinococcus granulosus orexin receptor type 2 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0623 0.0623
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0318 0.0318
Loa Loa (eye worm) beta-lactamase 0.0039 0.0364 0.0364
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0318 0.2057
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0364 0.0364
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Brugia malayi beta-lactamase family protein 0.0039 0.0364 0.0364
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0318 0.2057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Trypanosoma brucei hypothetical protein 0.012 0.2925 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0061 0.1072 0.1081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0318 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1287 1
Echinococcus granulosus serotonin receptor 0.0037 0.0318 0.2057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.2925 1
Brugia malayi neuropeptide F receptor 0.0037 0.0318 0.0318
Trichomonas vaginalis esterase, putative 0.0039 0.0364 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0318 0.2057
Echinococcus granulosus hypothetical protein 0.0037 0.0318 0.2057
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0061 0.1072 0.3665
Mycobacterium leprae Conserved hypothetical protein 0.0061 0.1072 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0061 0.1072 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0318 0.2057
Schistosoma mansoni opsin-like receptor 0.0037 0.0318 0.2057
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1287 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Brugia malayi hypothetical protein 0.0029 0.0068 0.0068
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0318 0.0318
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0318 0.0318
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0318 0.0318
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0364 0.2435
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.1072 0.1072
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0318 0.2057
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0318 0.2057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0061 0.1072 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0318 0.2057
Toxoplasma gondii ABC1 family protein 0.0039 0.0364 0.3399
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0364 0.2435
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0318 0.2057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0061 0.1072 0.1081
Loa Loa (eye worm) tumor suppressor 0.0344 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0318 0.0318
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0061 0.1072 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0318 0.2057
Schistosoma mansoni amine GPCR 0.0037 0.0318 0.2057
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0318 0.2057
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0364 0.1245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0318 0.2057
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0318 0.2057
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0318 0.2057
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0364 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1287 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0623 0.4553
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Brugia malayi RE15519p 0.0037 0.0318 0.0318
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0623 0.4553
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0318 0.0318
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0623 0.4553
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Echinococcus granulosus neuropeptide receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0318 0.2057
Schistosoma mansoni hypothetical protein 0.0037 0.0318 0.2057
Brugia malayi Serotonin receptor 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni hypothetical protein 0.0037 0.0318 0.2057
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0364 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0318 0.2057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.1287 0.1287
Leishmania major hypothetical protein, conserved 0.0039 0.0364 0.1245
Brugia malayi G protein-coupled receptor 0.0037 0.0318 0.0318
Schistosoma mansoni biogenic amine receptor 0.0037 0.0318 0.2057
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Trypanosoma brucei calpain-like protein, putative 0.012 0.2925 1
Loa Loa (eye worm) CYP4Cod1 0.0061 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Onchocerca volvulus 0.0039 0.0364 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni adenoreceptor 0.0037 0.0318 0.2057
Schistosoma mansoni amine GPCR 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0318 0.0318
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Loa Loa (eye worm) RNA binding protein 0.0068 0.1287 0.1287
Toxoplasma gondii cytochrome p450 superfamily protein 0.0061 0.1072 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0318 0.0318
Schistosoma mansoni amine GPCR 0.0037 0.0318 0.2057
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0318 0.2057
Brugia malayi larval opioid receptor 0.0037 0.0318 0.0318
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0061 0.1072 0.1081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni neuropeptide receptor 0.0037 0.0318 0.2057
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0061 0.1072 0.3665
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0318 0.2057
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0061 0.1072 1
Leishmania major cytochrome p450-like protein 0.0061 0.1072 0.3665
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0364 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0061 0.1072 0.1081
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.1072 0.3665
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.2925 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.2925 1
Brugia malayi cytochrome P450 0.0061 0.1072 0.1072
Trypanosoma cruzi cytochrome P450, putative 0.0061 0.1072 0.3665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0318 0.2057
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0318 0.2057
Onchocerca volvulus 0.0039 0.0364 1
Brugia malayi Cytochrome P450 family protein 0.0061 0.1072 0.1072
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0623 0.4553
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.012 0.2925 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0318 0.2057
Brugia malayi ORL1-like opioid receptor 0.0037 0.0318 0.0318
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0318 0.2057
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0318 0.0318
Schistosoma mansoni cytochrome P450 0.0061 0.1072 0.8238
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0364 0.0364
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0318 0.2057
Leishmania major cytochrome p450-like protein 0.0061 0.1072 0.3665
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.6911 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0061 0.1072 1
Echinococcus granulosus g protein coupled receptor 0.0037 0.0318 0.2057
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0318 0.2057
Brugia malayi G-protein coupled receptor 0.0037 0.0318 0.0318
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0318 0.0318
Leishmania major cytochrome p450-like protein 0.0061 0.1072 0.3665
Brugia malayi AKH receptor 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.2925 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni hypothetical protein 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Brugia malayi G-protein coupled receptor 0.0037 0.0318 0.0318
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0318 0.2057
Echinococcus granulosus sex peptide receptor 0.0037 0.0318 0.2057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.2925 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0061 0.1072 0.1081
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0318 0.0318
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0364 0.1245
Brugia malayi hypothetical protein 0.0037 0.0318 0.0318
Trypanosoma cruzi calpain cysteine peptidase, putative 0.012 0.2925 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0061 0.1072 1
Schistosoma mansoni myosin xvIII 0.0037 0.0318 0.2057
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0061 0.1072 0.1081
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.2925 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0623 0.0623
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0364 0.5
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0061 0.1072 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0061 0.1072 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0318 0.2057
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0318 0.2057
Schistosoma mansoni neuropeptide receptor 0.0037 0.0318 0.2057
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0061 0.1072 1
Brugia malayi sulfakinin receptor protein 0.0037 0.0318 0.0318
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0318 0.2057
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Onchocerca volvulus 0.0039 0.0364 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0364 0.1245
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0623 0.0623
Echinococcus granulosus somatostatin receptor 0.0037 0.0318 0.2057
Echinococcus multilocularis serotonin receptor 0.0037 0.0318 0.2057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0318 0.2057
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0061 0.1072 0.1081
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0318 0.0318
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0318 0.0318
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0061 0.1072 0.1081
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0318 0.2057
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.2925 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1287 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0318 0.0318
Schistosoma mansoni histamine h1 receptor 0.0037 0.0318 0.2057
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0318 0.2057
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0061 0.1072 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0318 0.0318
Brugia malayi neuropeptide F receptor 0.0037 0.0318 0.0318
Echinococcus granulosus neuropeptide s receptor 0.0037 0.0318 0.2057
Brugia malayi putative neuropeptide receptor 0.0037 0.0318 0.0318
Schistosoma mansoni hypothetical protein 0.0061 0.1072 0.8238
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0061 0.1072 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0318 0.2057
Brugia malayi Dopamine receptor protein 2 0.0037 0.0318 0.0318
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0318 0.2057
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0061 0.1072 0.1081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.0318 0.2057
Brugia malayi Cytochrome P450 family protein 0.0061 0.1072 0.1072
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0318 0.2057
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.2925 1
Brugia malayi RNA binding protein 0.0068 0.1287 0.1287
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0623 0.4553
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0061 0.1072 0.1081
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0318 0.2057
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0061 0.1072 0.1081
Brugia malayi beta-lactamase 0.0039 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0037 0.0318 0.0318
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0061 0.1072 1
Brugia malayi Temporarily assigned gene name protein 44 0.0029 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0068 0.0068
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0318 0.2057
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0061 0.1072 0.3665
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0318 0.2057

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.