TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 553.92 | Formula: C27H19ClF3N5O3
H donors: 0 H acceptors: 4 LogP: 4 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1cc(c2ccc(cc2)OC(F)(F)F)c(n(c1=O)C)COC(c1cncn1C)c1ccc(c(c1)Cl)C#N
InChi: 1S/C27H19ClF3N5O3/c1-35-15-34-13-23(35)25(17-3-4-18(11-32)22(28)10-17)38-14-24-21(9-19(12-33)26(37)36(24)2)16-5-7-20(8-6-16)39-27(29,30)31/h3-10,13,15,25H,14H2,1-2H3
InChiKey: VRUYMJKZIKNSKH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	farnesyltransferase, CAAX box, alpha	Starlite/ChEMBL	References
Homo sapiens	protein geranylgeranyltransferase type I, beta subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	geranylgeranyl transferase beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Candida albicans	beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)	Get druggable targets OG5_129786	All targets in OG5_129786
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Candida albicans	beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)	Get druggable targets OG5_129786	All targets in OG5_129786
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_129786	All targets in OG5_129786
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_129786	All targets in OG5_129786
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05955 protein geranylgeranyltransferase type I, beta subunit [EC:2.5.1.59], putative	Get druggable targets OG5_129786	All targets in OG5_129786
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_129786	All targets in OG5_129786
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein farnesyltransferase beta subunit	protein geranylgeranyltransferase type I, beta subunit	377 aa	361 aa	26.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.1072	0.3237
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0609	0.1179
Echinococcus granulosus	cysteine protease	0.0009	0.0034	0.0037
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0218	0.0356
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Onchocerca volvulus		0.0052	0.0932	0.6283
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0036	0.0609	0.1179
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0092	0.0113
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0036	0.0609	0.1484
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1429	0.2695
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0938	0.175
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.1429	0.1568
Brugia malayi	beta-lactamase family protein	0.0075	0.1429	0.27
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.3913	0.7948
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.004	0.0044
Onchocerca volvulus		0.0018	0.0218	0.0939
Leishmania major	cathepsin L-like protease	0.0068	0.1285	0.8904
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.3913	0.7948
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0218	0.0939
Onchocerca volvulus		0.0075	0.1429	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.3913	0.7948
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.1215	0.0645
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0895	0.6171
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0036	0.0609	0.1483
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.024	0.4914	0.5392
Schistosoma mansoni	hypothetical protein	0.0177	0.3585	0.3933
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.1429	0.2858
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.3913	0.7507
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0218	0.0356
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0609	0.4125
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.1215	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0092	0.0107
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.024	0.4914	0.5392
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.0895	0.6171
Mycobacterium tuberculosis	Conserved protein	0.0075	0.1429	0.0873
Loa Loa (eye worm)	fibroinase	0.0018	0.0218	0.0351
Schistosoma mansoni	hypothetical protein	0.0016	0.0186	0.0204
Mycobacterium ulcerans	lipase LipD	0.0075	0.1429	1
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.0895	0.1764
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Echinococcus multilocularis	survival motor neuron protein 1	0.0254	0.5201	0.5706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.1215	0.8372
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.1215	0.1333
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0186	0.0295
Brugia malayi	CXXC zinc finger family protein	0.0031	0.049	0.0882
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.1215	0.8372
Echinococcus multilocularis	dnaJ subfamily B	0.0439	0.9114	1
Brugia malayi	beta-lactamase	0.0075	0.1429	0.27
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.1429	0.2858
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.1429	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Mycobacterium tuberculosis	Probable hydrolase	0.0075	0.1429	0.0873
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0938	0.175
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0018	0.0218	0.0475
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0218	0.0239
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.0895	0.1661
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.059	0.1077
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0036	0.0609	0.4125
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.0895	0.1666
Echinococcus granulosus	GPCR family 2	0.0016	0.0186	0.0204
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0036	0.0609	0.0668
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0075	0.1429	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0609	0.1108
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.1429	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.1215	0.8372
Plasmodium vivax	vivapain-2	0.0018	0.0218	0.0475
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.1429	0.27
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0186	0.0204
Leishmania major	cathepsin L-like protease	0.0018	0.0218	0.0768
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.024	0.4914	0.5392
Mycobacterium tuberculosis	Probable lipase LipD	0.0075	0.1429	0.0873
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0036	0.0609	0.0668
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0218	0.0239
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0092	0.012
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0218	0.0356
Onchocerca volvulus		0.0018	0.0218	0.0939
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0036	0.0609	0.1484
Giardia lamblia	Rab geranylgeranyltransferase	0.005	0.0895	0.0864
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.005	0.0895	0.6171
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0075	0.1429	0.0873
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0895	0.0982
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0036	0.0609	0.1179
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.024	0.4914	0.9444
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0036	0.0609	0.1483
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0036	0.0609	0.0668
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0186	0.0204
Schistosoma mansoni	hypothetical protein	0.0439	0.9114	1
Echinococcus multilocularis	geminin	0.0177	0.3585	0.3933
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.0895	0.0982
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0609	0.4125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.3913	0.4293
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.122	0.1338
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0092	0.012
Mycobacterium leprae	Probable lipase LipE	0.0075	0.1429	0.5
Toxoplasma gondii	ABC1 family protein	0.0075	0.1429	0.4589
Schistosoma mansoni	hypothetical protein	0.0052	0.0932	0.1023
Echinococcus multilocularis	cpg binding protein	0.0033	0.0527	0.0578
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0117	0.0155
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.024	0.4914	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.059	0.1071
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.0895	0.2219
Echinococcus granulosus	cpg binding protein	0.0033	0.0527	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1429	0.2695
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1429	0.2695
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0932	0.1738
Schistosoma mansoni	cpg binding protein	0.0033	0.0527	0.0578
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0609	0.1179
Schistosoma mansoni	hypothetical protein	0.0036	0.059	0.0647
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0036	0.0609	0.1179
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0075	0.1429	0.0873
Plasmodium vivax	geranylgeranyltransferase, putative	0.0036	0.0609	0.1484
Mycobacterium tuberculosis	Conserved protein	0.0075	0.1429	0.0873
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.005	0.0895	0.2219
Schistosoma mansoni	hypothetical protein	0.0016	0.0186	0.0204
Loa Loa (eye worm)	ctsf protein	0.0018	0.0218	0.0351
Schistosoma mansoni	hypothetical protein	0.0016	0.0186	0.0204
Toxoplasma gondii	hypothetical protein	0.005	0.0895	0.2565
Mycobacterium tuberculosis	Probable esterase LipL	0.0075	0.1429	0.0873
Brugia malayi	cathepsin L-like precursor	0.0012	0.0092	0.0113
Leishmania major	cathepsin L-like protease	0.0018	0.0218	0.0768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0218	0.0377
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0609	0.1179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Leishmania major	farnesyltransferase beta subunit	0.0036	0.0609	0.3752
Schistosoma mansoni	cpg binding protein	0.0033	0.0527	0.0578
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.049	0.0876
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0034	0.0037
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.3913	0.7505
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0117	0.0161
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0018	0.0218	0.0475
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.0895	0.1764
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0218	0.0377
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0117	0.0155
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0036	0.0609	0.4125
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0938	0.1745
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0117	0.0597
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.1429	0.1568
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0895	0.6171
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0218	0.0239
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0092	0.012
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0036	0.0609	0.1108
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0037	0.0006
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0938	0.1745
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0218	0.0356
Mycobacterium tuberculosis	Conserved protein	0.0075	0.1429	0.0873
Onchocerca volvulus		0.0018	0.0218	0.0939
Trichomonas vaginalis	esterase, putative	0.0075	0.1429	0.2858
Trypanosoma cruzi	lanosterol synthase, putative	0.0036	0.0609	0.4125
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0036	0.0609	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0186	0.0289
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.2856	0.5784
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0975	0.6749
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.1429	1
Mycobacterium ulcerans	hypothetical protein	0.0075	0.1429	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0218	0.0239
Leishmania major	cathepsin L-like protease	0.0018	0.0218	0.0768
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0218	0.0351
Schistosoma mansoni	hypothetical protein	0.0016	0.0186	0.0204
Plasmodium vivax	vivapain-2	0.0018	0.0218	0.0475
Echinococcus granulosus	geminin	0.0177	0.3585	0.3933
Echinococcus granulosus	dnaJ subfamily B	0.0439	0.9114	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0218	0.0239
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0218	0.0239
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.3913	0.4293
Schistosoma mansoni	cpg binding protein	0.0031	0.049	0.0537
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0609	0.4125
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0117	0.0155
Onchocerca volvulus		0.0018	0.0218	0.0939
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.3913	1
Loa Loa (eye worm)	cysteine protease	0.0018	0.0218	0.0351
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.005	0.0895	0.0982
Onchocerca volvulus		0.0075	0.1429	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0075	0.1429	0.0873
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0895	0.6171
Echinococcus granulosus	cathepsin L	0.0009	0.0034	0.0037
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0218	0.0377
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0186	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Toxoplasma gondii	hypothetical protein	0.0143	0.2856	1
Echinococcus granulosus	cathepsin l1	0.0012	0.0092	0.0101
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0036	0.0609	0.1114
Schistosoma mansoni	hypothetical protein	0.0177	0.3585	0.3933
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.024	0.4914	0.9445
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0609	0.1483
Onchocerca volvulus		0.005	0.0895	0.6003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0218	0.0377
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.1285	0.8969
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0218	0.0239
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.1429	0.2858
Echinococcus multilocularis	cysteine protease	0.0018	0.0218	0.0239
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0895	0.6171
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.1285	0.8969
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0036	0.0609	0.1179
Onchocerca volvulus		0.0018	0.0218	0.0939
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.1429	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Echinococcus multilocularis	cathepsin L	0.0009	0.0034	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0609	0.1108
Brugia malayi	beta-lactamase family protein	0.0075	0.1429	0.27
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.005	0.0895	0.5927
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0895	0.0982
Onchocerca volvulus		0.0018	0.0218	0.0939
Leishmania major	cysteine peptidase A (CPA)	0.0018	0.0218	0.0768
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0036	0.0609	0.1484
Onchocerca volvulus		0.0031	0.049	0.2972
Loa Loa (eye worm)	histone methyltransferase	0.001	0.004	0.0005
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0117	0.0161
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0186	0.0204
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0895	0.6171
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.1429	0.2858
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.3913	1
Trypanosoma brucei	lanosterol synthase	0.0036	0.0609	0.4125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1429	0.2695
Loa Loa (eye worm)	hypothetical protein	0.0254	0.5201	1
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.1429	0.3596
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.024	0.4914	0.5392
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0218	0.0939
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0117	0.0597
Leishmania major	cathepsin L-like protease	0.0068	0.1285	0.8904
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1429	0.2695
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0092	0.0107
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0186	0.0295
Echinococcus multilocularis	cysteine protease	0.0018	0.0218	0.0239
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.1285	0.8969
Leishmania major	cathepsin L-like protease	0.0018	0.0218	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0218	0.0351
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.004	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3913	0.7505
Echinococcus granulosus	survival motor neuron protein 1	0.0254	0.5201	0.5706
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0932	0.1023
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0034	0.0037
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.0895	0.0982
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0218	0.0356
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0036	0.0609	0.0668
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0895	0.6171
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0018	0.0218	0.0475
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.3913	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.1429	0.2695
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.1429	1
Mycobacterium ulcerans	beta-lactamase	0.0075	0.1429	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Leishmania major	cathepsin L-like protease	0.0018	0.0218	0.0768
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0092	0.0101
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.1429	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.1159	0.8069
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0034	0.0037
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.1285	0.8969
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0092	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1429	0.2695
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0092	0.0113
Trypanosoma cruzi	lanosterol synthase, putative	0.0036	0.0609	0.4125
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0218	0.0377
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.1215	0.1333
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.1215	0.378
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0186	0.0289
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0034	0.0037
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.1429	0.2858
Echinococcus granulosus	cathepsin l1	0.0018	0.0218	0.0239
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.024	0.4914	1
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0036	0.0609	0.1484
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0218	0.0356
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0036	0.0609	0.0668
Leishmania major	hypothetical protein, conserved	0.0075	0.1429	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0218	0.0377
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0036	0.0609	0.1179
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0036	0.0609	0.1114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Brugia malayi	hypothetical protein	0.0254	0.5201	1
Leishmania major	cathepsin L-like protease	0.0068	0.1285	0.8904
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0036	0.0609	0.1484
Onchocerca volvulus		0.0018	0.0218	0.0939
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.1429	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0218	0.132
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.1215	0.1333
Loa Loa (eye worm)	beta-lactamase	0.0075	0.1429	0.2695
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.1429	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0218	0.0356
Leishmania major	geranylgeranyltransferase, putative	0.0036	0.0609	0.3752
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0218	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0092	0.0107
Onchocerca volvulus		0.0075	0.1429	1
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0895	0.6171
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0117	0.0597
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0609	0.4125
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0036	0.0609	0.4125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.3913	0.7948
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0218	0.0939
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.1215	0.8372
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0218	0.0239
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.1285	0.8969
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.3913	0.4293
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0036	0.0609	0.1179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0218	0.0377
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0186	0.0204

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 15 nM	In vitro effective concentration of the compound against farnesyltransferase (FT)	ChEMBL.	14592494
EC50 (binding)	= 15 nM	In vitro effective concentration of the compound against farnesyltransferase (FT)	ChEMBL.	14592494
IC50 (binding)	= 0.36 nM	In vitro inhibitory activity against farnesyltransferase (FT)	ChEMBL.	14592494
IC50 (binding)	= 0.36 nM	In vitro inhibitory activity against farnesyltransferase (FT)	ChEMBL.	14592494
IC50 (binding)	= 150 nM	In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I	ChEMBL.	14592494
IC50 (binding)	= 150 nM	In vitro inhibitory activity of the compound against Geranylgeranyl transferase type I	ChEMBL.	14592494

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 224602