Detailed information for compound 226489

Basic information

Technical information
  • TDR Targets ID: 226489
  • Name: 3-[(4-naphthalen-2-yloxybenzoyl)amino]benzoic acid
  • MW: 383.396 | Formula: C24H17NO4
  • H donors: 2 H acceptors: 3 LogP: 5.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)Oc1ccc2c(c1)cccc2)Nc1cccc(c1)C(=O)O
  • InChi: 1S/C24H17NO4/c26-23(25-20-7-3-6-19(14-20)24(27)28)17-9-11-21(12-10-17)29-22-13-8-16-4-1-2-5-18(16)15-22/h1-15H,(H,25,26)(H,27,28)
  • InChiKey: IEZNMUQOSWIBTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[4-(2-naphthyloxy)benzoyl]amino]benzoic acid
  • 3-[[[4-(2-naphthalenyloxy)phenyl]-oxomethyl]amino]benzoic acid
  • 3-[(4-naphthalen-2-yloxyphenyl)carbonylamino]benzoic acid
  • 3-[[4-(2-naphthoxy)benzoyl]amino]benzoic acid
  • 3-[[[4-(2-naphthyloxy)phenyl]-oxomethyl]amino]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0018 0.019 0.026
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0015 0.0106 0.0145
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0101
Brugia malayi SH2 domain containing protein 0.0019 0.0205 0.0281
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0019 0.0205 0.0205
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0133
Echinococcus multilocularis Spectrin alpha actinin 0.0011 0.002 0.002
Brugia malayi Variant SH3 domain containing protein 0.0023 0.031 0.0426
Echinococcus granulosus tyrosine protein kinase shark 0.0019 0.0205 0.0205
Brugia malayi hypothetical protein 0.0012 0.0027 0.0037
Trichomonas vaginalis AGC family protein kinase 0.002 0.0229 0.0561
Echinococcus granulosus Spectrin alpha actinin 0.0011 0.002 0.002
Brugia malayi Variant SH3 domain containing protein 0.0011 0.002 0.0027
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0012 0.0027 0.0027
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0011 0.002 0.002
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0011 0.002 0.002
Echinococcus granulosus endophilin A3 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Echinococcus multilocularis Immunoglobulin 0.0014 0.0073 0.0073
Echinococcus granulosus serine threonine protein kinase 0.0124 0.2822 0.2822
Onchocerca volvulus 0.0014 0.0097 0.0154
Echinococcus granulosus Immunoglobulin 0.0014 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0269 0.0369
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0018 0.019 0.019
Trypanosoma cruzi casein kinase II, putative 0.0162 0.3752 1
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0011 0.002 0.002
Toxoplasma gondii CMGC kinase, CK2 family 0.0162 0.3752 1
Echinococcus multilocularis activin receptor type 0.0013 0.0065 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.1506 0.3982
Plasmodium falciparum protein serine/threonine kinase-1 0.0076 0.1624 0.4228
Giardia lamblia Kinase, CMGC CLK 0.0076 0.1624 0.0522
Echinococcus granulosus hypothetical protein 0.007 0.1473 0.1473
Onchocerca volvulus 0.0019 0.0205 0.0371
Echinococcus granulosus expressed protein 0.0011 0.002 0.002
Entamoeba histolytica protein kinase domain containing protein 0.0013 0.0065 0.0119
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0191 0.4486 0.6159
Trichomonas vaginalis AGC family protein kinase 0.002 0.0229 0.0561
Entamoeba histolytica protein kinase, putative 0.002 0.0229 0.0561
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0488 0.0488
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0015 0.0106 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Schistosoma mansoni tyrosine kinase 0.0099 0.2208 0.2193
Echinococcus multilocularis dnaJ subfamily B 0.0413 1 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0015 0.0106 0.0106
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.3752 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.002 0.0246 0.0226
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Entamoeba histolytica protein kinase, putative 0.0018 0.019 0.0455
Echinococcus granulosus tyrosine protein kinase Blk 0.0019 0.0205 0.0205
Schistosoma mansoni protein kinase C mu 0.0015 0.0106 0.0086
Echinococcus multilocularis serine:threonine protein kinase N2 0.0018 0.019 0.019
Loa Loa (eye worm) AUR protein kinase 0.0071 0.1506 0.2068
Entamoeba histolytica protein kinase, putative 0.0071 0.1506 0.3982
Brugia malayi Variant SH3 domain containing protein 0.0011 0.002 0.0027
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0191 0.4486 0.6159
Onchocerca volvulus 0.0012 0.0027 0.0015
Schistosoma mansoni tensin-related 0.0012 0.0027 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Entamoeba histolytica casein kinase, putative 0.0162 0.3752 1
Echinococcus multilocularis aurora kinase A 0.0071 0.1506 0.1506
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0191 0.4486 0.8982
Schistosoma mansoni suppressor of cytokine signaling 0.0012 0.0027 0.0007
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0019 0.0205 0.0205
Brugia malayi Uncoordinated protein 44 0.002 0.0237 0.0325
Schistosoma mansoni growth factor receptor-bound protein 0.0023 0.031 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.2822 0.2808
Schistosoma mansoni serine/threonine kinase 0.0018 0.019 0.017
Brugia malayi SRC-1 0.003 0.0488 0.067
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0099 0.2208 0.2208
Plasmodium falciparum casein kinase 2, alpha subunit 0.0162 0.3752 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0012 0.0039 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.047 0.0645
Brugia malayi serine/threonine-protein kinase 6 0.0071 0.1506 0.2068
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0012 0.0027 0.0027
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0015 0.0106 0.0145
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.002 0.0246 0.0246
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0488 0.0488
Entamoeba histolytica protein kinase, putative 0.0018 0.0178 0.0422
Echinococcus multilocularis insulin receptor 0.0062 0.1269 0.1269
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0091 0.0072
Echinococcus granulosus aurora kinase A 0.0071 0.1506 0.1506
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.3752 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0019 0.0205 0.0205
Echinococcus granulosus protein kinase c epsilon type 0.0027 0.0408 0.0408
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.0007
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.002 0.0246 0.0246
Onchocerca volvulus 0.0019 0.0205 0.0371
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0023 0.031 0.0291
Echinococcus multilocularis casein kinase ii subunit alpha 0.0162 0.3752 0.3752
Schistosoma mansoni apoptosis stimulating of P53 0.0011 0.002 0.000000065257
Leishmania major protein kinase, putative 0.0071 0.1506 0.391
Echinococcus granulosus c src tyrosine kinase 0.003 0.0488 0.0488
Echinococcus granulosus dual specificity protein kinase clk2 0.0076 0.1624 0.1624
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0191 0.4486 0.6159
Brugia malayi Immunoglobulin I-set domain containing protein 0.0226 0.5352 0.7349
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.1624 0.4297
Brugia malayi Protein kinase domain containing protein 0.0076 0.1624 0.2229
Echinococcus granulosus hypothetical protein 0.0012 0.0027 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.019 0.017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0101
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.002 0.0236 0.0324
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0101
Loa Loa (eye worm) hypothetical protein 0.005 0.0969 0.1331
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0012 0.0027 0.0007
Echinococcus granulosus epidermal growth factor receptor 0.018 0.4205 0.4205
Brugia malayi serine/threonine kinase 12 0.0071 0.1506 0.2068
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.002 0.0236 0.0236
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0011 0.002 0.002
Echinococcus granulosus casein kinase ii subunit alpha 0.0162 0.3752 0.3752
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0106 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0408 0.0389
Trichomonas vaginalis helicase, putative 0.0013 0.006 0.0108
Schistosoma mansoni tensin 0.0012 0.0027 0.0007
Schistosoma mansoni tyrosine kinase 0.0092 0.2031 0.2015
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0011 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0413 1 1
Schistosoma mansoni vesicular amine transporter 0.0014 0.0073 0.0053
Schistosoma mansoni GTPase activating protein 0.0012 0.0027 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0183 0.0251
Schistosoma mansoni tyrosine kinase 0.0176 0.4119 0.4108
Brugia malayi Myosin tail family protein 0.0011 0.002 0.0027
Brugia malayi Protein kinase domain containing protein 0.0019 0.0205 0.0281
Echinococcus multilocularis roundabout 2 0.0021 0.0269 0.0269
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0226 0.5352 0.7349
Echinococcus multilocularis protein kinase c iota type 0.0027 0.0408 0.0408
Schistosoma mansoni tensin 0.0012 0.0027 0.0007
Echinococcus granulosus death domain containing protein 0.002 0.0236 0.0236
Brugia malayi Protein kinase domain containing protein 0.0019 0.0205 0.0281
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0011 0.002 0.002
Schistosoma mansoni vav2 0.0022 0.0285 0.0266
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0062 0.1269 0.1269
Onchocerca volvulus 0.0012 0.0027 0.0015
Loa Loa (eye worm) STAT protein 0.0012 0.0027 0.0037
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0191 0.4486 0.4486
Onchocerca volvulus 0.0057 0.1164 0.2301
Echinococcus multilocularis SH2 motif 0.0012 0.0027 0.0027
Loa Loa (eye worm) thyroid receptor interactor 0.0011 0.002 0.0027
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0019 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0013 0.0067 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.1624 0.1607
Echinococcus multilocularis protein tyrosine kinase 0.03 0.7197 0.7197
Brugia malayi Tensin 0.0012 0.0027 0.0037
Brugia malayi SH2 domain containing protein 0.0012 0.0027 0.0037
Loa Loa (eye worm) RhoGAP domain-containing protein 0.002 0.0246 0.0337
Echinococcus multilocularis Immunoglobulin 0.0014 0.0073 0.0073
Onchocerca volvulus 0.0012 0.0027 0.0015
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0091 0.0091
Entamoeba histolytica hypothetical protein 0.0013 0.006 0.0106
Schistosoma mansoni tyrosine kinase 0.0015 0.011 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0097 0.0205
Brugia malayi SH2 domain containing protein 0.0012 0.0027 0.0037
Echinococcus multilocularis c src tyrosine kinase 0.003 0.0488 0.0488
Brugia malayi protein-tyrosine kinase 0.0011 0.002 0.0027
Schistosoma mansoni tyrosine kinase 0.003 0.0488 0.0469
Echinococcus granulosus SH2 motif 0.0012 0.0027 0.0027
Echinococcus granulosus serine:threonine protein kinase N2 0.0018 0.019 0.019
Trichomonas vaginalis STE family protein kinase 0.0124 0.2822 0.7509
Trichomonas vaginalis STE family protein kinase 0.0124 0.2822 0.7509
Brugia malayi Protein kinase domain containing protein 0.0056 0.112 0.1537
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0011 0.002 0.002
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.047 0.0645
Loa Loa (eye worm) AGC/PKN protein kinase 0.0018 0.019 0.026
Trichomonas vaginalis AGC family protein kinase 0.0071 0.1506 0.3982
Brugia malayi Variant SH3 domain containing protein 0.002 0.0246 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.003 0.0488 0.0488
Leishmania major protein kinase, putative 0.0076 0.1624 0.4228
Loa Loa (eye worm) CAMK/DAPK/DAPK protein kinase 0.0036 0.062 0.0852
Entamoeba histolytica protein kinase domain containing protein 0.0162 0.3752 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.1624 0.4297
Echinococcus granulosus growth factor receptor bound protein 2 0.0026 0.0387 0.0387
Echinococcus granulosus tyrosine protein kinase Src42A 0.0015 0.0104 0.0104
Echinococcus multilocularis serine:threonine protein kinase 38 0.0018 0.019 0.019
Trypanosoma brucei aurora B kinase 0.0071 0.1506 0.3982
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0018 0.019 0.019
Echinococcus multilocularis epidermal growth factor receptor 0.0099 0.2208 0.2208
Leishmania major protein kinase, putative 0.0076 0.1624 0.4228
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.4205 0.5774
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.019 0.017
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.4486 0.4475
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Schistosoma mansoni tyrosine kinase 0.0092 0.2031 0.2015
Echinococcus multilocularis raf serine:threonine protein kinase 0.0016 0.0133 0.0133
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0076 0.1624 0.4228
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.003 0.0488 0.0488
Entamoeba histolytica protein kinase , putative 0.0071 0.1506 0.3982
Brugia malayi SH2 domain containing protein 0.0019 0.0205 0.0281
Echinococcus multilocularis nostrin 0.0011 0.002 0.002
Schistosoma mansoni tyrosine kinase 0.0062 0.1269 0.1251
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0178 0.0245
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0018 0.019 0.026
Trichomonas vaginalis AGC family protein kinase 0.0071 0.1506 0.3982
Trichomonas vaginalis AGC family protein kinase 0.002 0.0229 0.0561
Loa Loa (eye worm) AGC/AKT protein kinase 0.002 0.0229 0.0315
Onchocerca volvulus 0.0019 0.0205 0.0371
Echinococcus granulosus protein kinase c iota type 0.0027 0.0408 0.0408
Brugia malayi Variant SH3 domain containing protein 0.0011 0.002 0.0027
Echinococcus granulosus Protein kinase C brain isozyme 0.0027 0.0408 0.0408
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.003 0.0488 0.0488
Loa Loa (eye worm) SH2 domain-containing protein 0.0012 0.0027 0.0037
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0013 0.006 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.062 0.0602
Brugia malayi SH3 domain containing protein 0.0011 0.002 0.0027
Echinococcus granulosus tyrosine kinase 0.0019 0.0205 0.0205
Echinococcus granulosus tyrosine kinase 0.0019 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0179 0.4183 0.5744
Echinococcus granulosus epidermal growth factor receptor 0.0099 0.2208 0.2208
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0191 0.4486 0.4486
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0011 0.002 0.0027
Schistosoma mansoni suppressor of cytokine signaling 0.0012 0.0027 0.0007
Echinococcus granulosus twitchin 0.0023 0.031 0.031
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0012 0.0027 0.0037
Brugia malayi Sex muscle abnormal protein 5 0.0023 0.031 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0097 0.0205
Brugia malayi Tyrosine-protein kinase abl-1 0.003 0.0488 0.067
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.1624 0.4297
Schistosoma mansoni protein kinase 0.0013 0.0065 0.0045
Brugia malayi SH2 domain containing protein 0.0012 0.0027 0.0037
Echinococcus multilocularis Ankyrin 0.002 0.0237 0.0237
Echinococcus multilocularis 0.0054 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0346 0.0475
Echinococcus granulosus NDR protein kinase 0.0018 0.019 0.019
Loa Loa (eye worm) p53BP2 0.0011 0.002 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Echinococcus multilocularis SH2 motif 0.0012 0.0027 0.0027
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0014 0.0083 0.0114
Leishmania major casein kinase II, putative 0.0162 0.3752 1
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.3752 1
Loa Loa (eye worm) protein-tyrosine kinase 0.0011 0.002 0.0027
Echinococcus granulosus tyrosine protein kinase Srms 0.0019 0.0205 0.0205
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0108
Loa Loa (eye worm) AUR protein kinase 0.0071 0.1506 0.2068
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0018 0.019 0.019
Brugia malayi Protein kinase c protein 2 0.0015 0.0106 0.0145
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0124 0.2822 0.3875
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0067 0.0092
Brugia malayi STAT protein, DNA binding domain containing protein 0.0012 0.0027 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0162 0.3752 0.5152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Loa Loa (eye worm) TK/FAK protein kinase 0.0304 0.7283 1
Trichomonas vaginalis AGC family protein kinase 0.002 0.0229 0.0561
Brugia malayi tRNA modification GTPase TrmE family protein 0.0012 0.0027 0.0037
Echinococcus granulosus protein tyrosine kinase 0.03 0.7197 0.7197
Brugia malayi Variant SH3 domain containing protein 0.0011 0.002 0.0027
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0062 0.1269 0.1269
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0018 0.019 0.026
Brugia malayi SH2 domain containing protein 0.0012 0.0027 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.006 0.0108
Brugia malayi p70 ribosomal S6 kinase beta 0.0018 0.019 0.026
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0015 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.003 0.0488 0.0488
Schistosoma mansoni tyrosine kinase 0.018 0.4205 0.4194
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0071 0.1506 0.3982
Echinococcus multilocularis tyrosine protein kinase shark 0.0019 0.0205 0.0205
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.4205 0.4205
Echinococcus multilocularis SH2 motif 0.0012 0.0027 0.0027
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0114 0.2581 0.2581
Entamoeba histolytica protein kinase, putative 0.0071 0.1506 0.3982
Brugia malayi hypothetical protein 0.0019 0.0205 0.0281
Plasmodium falciparum protein kinase, putative 0.0124 0.2822 0.7478
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Brugia malayi Protein kinase domain containing protein 0.0015 0.0106 0.0145
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0101
Brugia malayi Casein kinase II, alpha chain 0.0162 0.3752 0.5152
Brugia malayi Protein kinase domain containing protein 0.0304 0.7283 1
Brugia malayi Variant SH3 domain containing protein 0.0023 0.031 0.0426
Loa Loa (eye worm) TK protein kinase 0.0019 0.0205 0.0281
Entamoeba histolytica protein kinase, putative 0.0124 0.2822 0.7509
Schistosoma mansoni protein kinase 0.0162 0.3752 0.374
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0162 0.3752 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0019 0.0205 0.0281
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0018 0.019 0.0455
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.002 0.0236 0.0236
Toxoplasma gondii AGC kinase 0.0018 0.019 0.034
Brugia malayi protein kinase C3,putative 0.0015 0.0106 0.0145
Echinococcus granulosus roundabout 2 0.0021 0.0269 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.1624 0.1607
Echinococcus granulosus activin receptor type 0.0013 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0027
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.1624 0.4297
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0065 0.0119
Echinococcus granulosus nostrin 0.0011 0.002 0.002
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0012 0.0027 0.0027
Loa Loa (eye worm) guanylate kinase 0.0011 0.002 0.0027
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0012 0.0027 0.0037
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0012 0.0027 0.0015
Brugia malayi Hr1 repeat family protein 0.0018 0.019 0.026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.006 0.0108
Echinococcus multilocularis 0.0012 0.0027 0.0027
Echinococcus granulosus SH2 domain containing adapter protein F 0.0012 0.0027 0.0027
Echinococcus multilocularis SH2 domain containing protein 7 0.0012 0.0027 0.0027
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0014 0.0073 0.0073
Echinococcus granulosus suppressor of cytokine signaling 6 0.0012 0.0027 0.0027
Echinococcus multilocularis growth factor receptor bound protein 2 0.0023 0.031 0.031
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.1624 0.4297
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.2788 0.2773
Echinococcus granulosus protein kinase C gamma type 0.0018 0.019 0.019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0108
Onchocerca volvulus 0.0201 0.4729 0.947
Loa Loa (eye worm) CAMK/DAPK/DAPK protein kinase 0.0036 0.062 0.0852
Loa Loa (eye worm) SH2 domain-containing protein 0.0012 0.0027 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0027
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.003 0.0488 0.0488
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0205 0.0205
Brugia malayi Spectrin alpha chain 0.0011 0.002 0.0027
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0018 0.0178 0.0422
Onchocerca volvulus 0.0017 0.017 0.0303
Schistosoma mansoni tyrosine kinase 0.03 0.7197 0.7191
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0013 0.0065 0.0065
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0011 0.002 0.0027
Trichomonas vaginalis AGC family protein kinase 0.002 0.0229 0.0561
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0027
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0076 0.1624 0.4297
Echinococcus granulosus netrin receptor unc 5 0.0025 0.0346 0.0346
Schistosoma mansoni atypical protein kinase C 0.0027 0.0408 0.0389
Brugia malayi cytokine inducible SH2-containing protein 5 0.0012 0.0027 0.0037
Brugia malayi protein-tyrosine kinase 0.0019 0.0205 0.0281
Schistosoma mansoni tyrosine kinase 0.0099 0.2208 0.2193
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0124 0.2822 0.586
Echinococcus multilocularis tyrosine protein kinase Fgr 0.003 0.0488 0.0488
Brugia malayi Peripheral plasma membrane protein CASK 0.0011 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Brugia malayi Protein kinase domain containing protein 0.0062 0.1269 0.1742
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0012 0.0027 0.0027
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0065 0.0119
Schistosoma mansoni cpg binding protein 0.0061 0.1246 0.1228
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0018 0.019 0.0455
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0071 0.1506 0.1506
Loa Loa (eye worm) AUR protein kinase 0.0071 0.1506 0.2068
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0027 0.0408 0.0561
Echinococcus multilocularis serine threonine protein kinase 0.0124 0.2822 0.2822
Loa Loa (eye worm) hypothetical protein 0.0161 0.373 0.5122
Brugia malayi hypothetical protein 0.0014 0.0073 0.0101
Echinococcus granulosus signal transduction protein lnk realted 0.0012 0.0027 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0408 0.0389
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0106 0.0086
Echinococcus granulosus SH2 domain containing protein 7 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.0471 0.0647
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0185 0.4326 0.4326
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0076 0.1624 0.2229
Schistosoma mansoni nck2/grb4 0.0023 0.031 0.0291
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0173 0.0237
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.002 0.0236 0.0216
Trichomonas vaginalis AGC family protein kinase 0.002 0.0229 0.0561
Echinococcus granulosus N chimaerin 0.002 0.0246 0.0246
Brugia malayi SH2 domain containing protein 0.0012 0.0027 0.0037
Brugia malayi CXXC zinc finger family protein 0.0057 0.1164 0.1599
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.2441 0.6446
Schistosoma mansoni SH2A 0.0012 0.0027 0.0007
Trichomonas vaginalis AGC family protein kinase 0.002 0.0229 0.0561
Echinococcus multilocularis tensin 0.0012 0.0027 0.0027
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0012 0.0027 0.0027
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0067 0.0092
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0027
Schistosoma mansoni signal transduction protein lnk-related 0.0012 0.0027 0.0007
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0013 0.0065 0.0065
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0073 0.0101
Echinococcus multilocularis intersectin 2 0.0014 0.0097 0.0097
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0185 0.4326 0.4326
Schistosoma mansoni tensin-related 0.0012 0.0027 0.0007
Echinococcus granulosus tensin 0.0012 0.0027 0.0027
Entamoeba histolytica protein kinase, putative 0.0018 0.019 0.0455
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0027 0.0408 0.0408
Echinococcus multilocularis tyrosine protein kinase Src42A 0.003 0.0488 0.0488
Leishmania major hypothetical protein, conserved 0.0014 0.0097 0.0087
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0014 0.0073 0.0053
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0011 0.002 0.002
Echinococcus granulosus SH2 motif 0.0012 0.0027 0.0027
Schistosoma mansoni netrin receptor unc5 0.0025 0.0346 0.0326
Onchocerca volvulus 0.0012 0.0027 0.0015
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0071 0.1506 0.3982
Echinococcus granulosus tyrosine protein kinase Src64B 0.003 0.0488 0.0488
Onchocerca volvulus Netrin receptor homolog 0.0024 0.0322 0.0607
Schistosoma mansoni cpg binding protein 0.0061 0.1246 0.1228
Schistosoma mansoni tensin 0.0012 0.0027 0.0007
Trypanosoma brucei rac serine-threonine kinase, putative 0.002 0.0229 0.0561
Echinococcus granulosus Ankyrin 0.002 0.0236 0.0236
Entamoeba histolytica SH2 domain containing protein 0.0012 0.0027 0.0019
Schistosoma mansoni tyrosine kinase 0.0019 0.0205 0.0185
Schistosoma mansoni tyrosine kinase 0.0062 0.1269 0.1251
Trichomonas vaginalis AGC family protein kinase 0.0071 0.1506 0.3982
Echinococcus multilocularis transfer RNA-Ala 0.0011 0.002 0.002
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0023 0.031 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Schistosoma mansoni dynamin-associated protein 0.0014 0.0097 0.0077
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0071 0.1506 0.1506
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0408 0.0389
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0027
Loa Loa (eye worm) TK/INSR protein kinase 0.0062 0.1269 0.1742
Echinococcus multilocularis tyrosine protein kinase Src64B 0.003 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0021 0.0269 0.0369
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.3752 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0019 0.0205 0.0205
Echinococcus granulosus cpg binding protein 0.0061 0.1246 0.1246
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Loa Loa (eye worm) SH2 domain-containing protein 0.0012 0.0027 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.019 0.017
Echinococcus multilocularis endophilin A3 0.0011 0.002 0.002
Echinococcus multilocularis dual specificity protein kinase clk2 0.0076 0.1624 0.1624
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.3752 1
Schistosoma mansoni protein kinase 0.0071 0.1506 0.1489
Brugia malayi Protein kinase domain containing protein 0.0019 0.0205 0.0281
Schistosoma mansoni growth factor receptor-bound protein 0.0026 0.0387 0.0368
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0018 0.019 0.026
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0012 0.0027 0.0007
Schistosoma mansoni nephrin 0.0017 0.0159 0.014
Schistosoma mansoni shc transforming protein 0.0012 0.0027 0.0007
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0018 0.019 0.026
Trichomonas vaginalis AGC family protein kinase 0.002 0.0229 0.0561
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0065 0.0119
Echinococcus granulosus NCK adaptor protein 0.0023 0.031 0.031
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0018 0.019 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Echinococcus multilocularis tyrosine kinase 0.0019 0.0205 0.0205
Plasmodium falciparum serine/threonine protein kinase, putative 0.0071 0.1506 0.391
Echinococcus granulosus src region 0.0011 0.002 0.002
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0018 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0488 0.0488
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0018 0.019 0.019
Echinococcus multilocularis protein kinase c epsilon type 0.0027 0.0408 0.0408
Loa Loa (eye worm) SRC-1 0.003 0.0488 0.067
Echinococcus granulosus tyrosine protein kinase Src42A 0.003 0.0488 0.0488
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0012 0.0027 0.0027
Giardia lamblia Kinase, CMGC CK2 0.0162 0.3752 1
Trypanosoma brucei protein kinase, putative 0.0013 0.0065 0.0119
Loa Loa (eye worm) hypothetical protein 0.017 0.3949 0.5422
Echinococcus granulosus suppressor of cytokine signaling 7 0.0012 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase Abl 0.003 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0027
Echinococcus multilocularis tyrosine protein kinase Blk 0.0019 0.0205 0.0205
Echinococcus multilocularis tyrosine protein kinase Fyn 0.003 0.0488 0.0488
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0018 0.019 0.019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0108
Echinococcus multilocularis 0.007 0.1473 0.1473
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0013 0.006 0.006
Echinococcus multilocularis NCK adaptor protein 0.0026 0.0387 0.0387
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0071 0.1506 0.3982
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.1506 0.1489
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0015 0.0104 0.0104
Echinococcus granulosus defective proboscis extension response 0.0014 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0018 0.019 0.0455
Echinococcus granulosus intersectin 2 0.0014 0.0097 0.0097
Onchocerca volvulus 0.0161 0.373 0.7462
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0012 0.0027 0.0027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0027
Brugia malayi Death domain containing protein 0.002 0.0236 0.0324
Brugia malayi Protein kinase domain containing protein 0.0019 0.0205 0.0281
Onchocerca volvulus 0.0019 0.0205 0.0371
Loa Loa (eye worm) hypothetical protein 0.002 0.0237 0.0325
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Plasmodium vivax serine/threonine kinase-1, putative 0.0076 0.1624 0.0522
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0178 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.006 0.0108
Brugia malayi Fibronectin type III domain containing protein 0.0014 0.0073 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0071 0.1506 0.3982
Entamoeba histolytica protein kinase, putative 0.002 0.0229 0.0561
Brugia malayi Guanylate kinase family protein 0.0011 0.002 0.0027
Trypanosoma brucei Casein kinase II 0.0162 0.3752 1
Trypanosoma cruzi aurora B kinase, putative 0.0071 0.1506 0.3982
Loa Loa (eye worm) hypothetical protein 0.007 0.1473 0.2023
Loa Loa (eye worm) hypothetical protein 0.0161 0.373 0.5122
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.3752 1
Toxoplasma gondii aurora kinase 0.0071 0.1506 0.391
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0091 0.0091
Onchocerca volvulus 0.0012 0.0027 0.0015
Brugia malayi Protein kinase domain containing protein 0.0019 0.0205 0.0281
Schistosoma mansoni tyrosine kinase 0.0092 0.2031 0.2015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0108
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0012 0.0027 0.0027
Echinococcus multilocularis signal transduction protein lnk realted 0.0012 0.0027 0.0027
Echinococcus granulosus neuroglian 0.0017 0.0159 0.0159
Brugia malayi RhoGAP domain containing protein 0.002 0.0246 0.0337
Schistosoma mansoni protein kinase 0.0013 0.0065 0.0045
Brugia malayi protein kinase C II. 0.0027 0.0408 0.0561
Echinococcus multilocularis tensin 0.0012 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Fyn 0.003 0.0488 0.0488
Echinococcus multilocularis serine threonine protein kinase 0.0018 0.019 0.019
Schistosoma mansoni protein kinase 0.0013 0.0065 0.0045
Schistosoma mansoni hypothetical protein 0.002 0.0236 0.0216
Echinococcus multilocularis netrin receptor unc 5 0.0025 0.0346 0.0346
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0108
Echinococcus multilocularis tyrosine protein kinase Srms 0.0019 0.0205 0.0205
Onchocerca volvulus 0.0019 0.0205 0.0371
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0011 0.002 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0012 0.0027 0.0015
Brugia malayi Src substrate cortactin 0.0011 0.002 0.0027
Echinococcus multilocularis cpg binding protein 0.0061 0.1246 0.1246
Brugia malayi SH2 domain containing protein 0.0012 0.0027 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.2765 0.275
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.4205 0.5774
Loa Loa (eye worm) hypothetical protein 0.0019 0.0205 0.0281
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.002 0.0246 0.0226
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.0007
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0488 0.0469
Brugia malayi Protein kinase domain containing protein 0.002 0.0229 0.0315
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0076 0.1624 0.4297
Brugia malayi SH2 domain containing protein 0.0012 0.0027 0.0037
Echinococcus granulosus tyrosine protein kinase Lyn 0.0036 0.0638 0.0638
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Schistosoma mansoni adapter molecule crk 0.0023 0.031 0.0291
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0114 0.2581 0.2581
Brugia malayi C1-like domain containing protein 0.0015 0.0106 0.0145
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0097 0.0133
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0161 0.373 0.5122
Loa Loa (eye worm) hypothetical protein 0.0036 0.062 0.0852
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Echinococcus granulosus epidermal growth factor receptor kinase 0.0011 0.002 0.002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.1164 0.1599
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.019 0.017
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.3752 1
Echinococcus multilocularis SHC transforming protein 3 0.0012 0.0027 0.0027
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0205 0.0281
Schistosoma mansoni tyrosine kinase 0.003 0.0488 0.0469
Onchocerca volvulus 0.0012 0.0027 0.0015
Brugia malayi Variant SH3 domain containing protein 0.0011 0.002 0.0027
Echinococcus granulosus SHC transforming protein 3 0.0012 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.006 0.0108
Echinococcus granulosus raf serine:threonine protein kinase 0.0016 0.0133 0.0133
Onchocerca volvulus 0.0019 0.0205 0.0371
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0014 0.0073 0.0053
Echinococcus multilocularis N chimaerin 0.002 0.0246 0.0246
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0011 0.002 0.002
Onchocerca volvulus Tyrosine kinase homolog 0.0212 0.4992 1
Echinococcus granulosus insulin receptor 0.0062 0.1269 0.1269
Echinococcus multilocularis serine:threonine protein kinase N2 0.0018 0.019 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0133 0.0113
Echinococcus granulosus expressed conserved protein 0.0012 0.0027 0.0027
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0013 0.006 0.006
Echinococcus granulosus fch and double sh3 domains protein 2 0.0011 0.002 0.002
Schistosoma mansoni cell adhesion molecule 0.0018 0.0183 0.0163
Echinococcus multilocularis expressed protein 0.0011 0.002 0.002
Plasmodium vivax unspecified product 0.0162 0.3752 1
Echinococcus multilocularis neuroglian 0.0017 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0101
Loa Loa (eye worm) AGC/NDR protein kinase 0.0018 0.019 0.026
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0019 0.0205 0.0495
Brugia malayi Protein kinase domain containing protein 0.0018 0.019 0.026
Schistosoma mansoni tyrosine kinase 0.003 0.0488 0.0469
Schistosoma mansoni tyrosine kinase 0.003 0.0488 0.0469
Schistosoma mansoni cpg binding protein 0.0057 0.1164 0.1147
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.031 0.0426
Brugia malayi serine/threonine protein kinase 6 0.0071 0.1506 0.2068
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0023 0.031 0.0426
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0012 0.0027 0.0037
Brugia malayi Fes/CIP4 homology domain containing protein 0.0011 0.002 0.0027
Brugia malayi Protein kinase domain containing protein 0.0191 0.4486 0.6159
Schistosoma mansoni ankyrin 23/unc44 0.002 0.0237 0.0217

Activities

Activity type Activity value Assay description Source Reference
Cell viability (functional) = -14.5 Tested for human PBMC cell viability, cultured with alpha-CD40, IL-4 and IL-10 at 3 microM (a negative number means enhancement of cell viability) ChEMBL. 9046329
Suppression (functional) = -29.6 % In vitro inhibition of IgE antibody production in human PBMC cultured with alpha-CD40, IL-4 and IL-10 at 3 microM concentration (negative number means enhancement of cell viability) ChEMBL. 9046329
Suppression (functional) = 2.5 % In vitro inhibition of IgG antibody production in human PBMC cultured with alpha-CD40, IL-4 and IL-10 at 3 microM concentration ChEMBL. 9046329

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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