Detailed information for compound 233204

Basic information

Technical information
  • TDR Targets ID: 233204
  • Name: (5R,6S)-3-[[(2S,4R)-2-carbamoyl-4-hydroxypyrr olidin-1-yl]methyl]-6-[(1R)-1-hydroxyethyl]-7 -oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-c arboxylic acid
  • MW: 357.382 | Formula: C14H19N3O6S
  • H donors: 4 H acceptors: 6 LogP: -3.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CN([C@@H](C1)C(=O)N)CC1=C(C(=O)O)N2[C@H](S1)[C@H](C2=O)[C@H](O)C
  • InChi: 1S/C14H19N3O6S/c1-5(18)9-12(21)17-10(14(22)23)8(24-13(9)17)4-16-3-6(19)2-7(16)11(15)20/h5-7,9,13,18-19H,2-4H2,1H3,(H2,15,20)(H,22,23)/t5-,6-,7+,9+,13-/m1/s1
  • InChiKey: AEVVONUBUXGZIY-HVUOKHHXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5R,6S)-3-[[(2S,4R)-2-carbamoyl-4-hydroxy-pyrrolidin-1-yl]methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-[[(2S,4R)-2-carbamoyl-4-hydroxy-1-pyrrolidinyl]methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-[[(2S,4R)-2-aminocarbonyl-4-hydroxy-pyrrolidin-1-yl]methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-[[(2S,4R)-2-carbamoyl-4-hydroxy-pyrrolidino]methyl]-6-[(1R)-1-hydroxyethyl]-7-keto-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-[[(2S,4R)-2-carbamoyl-4-hydroxypyrrolidin-1-yl]methyl]-6-(1-hydroxyethyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-[[(2S,4R)-2-carbamoyl-4-hydroxy-pyrrolidin-1-yl]methyl]-6-(1-hydroxyethyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-[[(2S,4R)-2-carbamoyl-4-hydroxy-1-pyrrolidinyl]methyl]-6-(1-hydroxyethyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-[[(2S,4R)-2-carbamoyl-4-hydroxy-pyrrolidin-1-yl]methyl]-6-(1-hydroxyethyl)-7-keto-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-3-[[(2S,4R)-2-aminocarbonyl-4-hydroxy-pyrrolidin-1-yl]methyl]-6-(1-hydroxyethyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0039 0.0011 0.0011
Onchocerca volvulus 0.0089 0.0068 0.0068
Onchocerca volvulus 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.1416 0.1575 0.1575
Echinococcus multilocularis fat cadherin tumor suppressor 0.0089 0.0068 0.0068
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.8833 1 1
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0043 0.0016 0.0016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0009 0.5
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.1499 0.167 0.5
Echinococcus multilocularis neurogenic locus protein delta 0.0089 0.0068 0.0068
Brugia malayi Calcium binding EGF domain containing protein 0.0089 0.0068 0.0068
Onchocerca volvulus 0.0116 0.0099 0.0099
Echinococcus multilocularis nAChR subunit 0.0063 0.0038 0.0038
Echinococcus granulosus g protein coupled receptor 0.0166 0.0156 0.0156
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0051 0.0025 0.0149
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0028 0.0028
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.0038 0.0038
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0014 0.0014
Echinococcus granulosus tachykinin peptides receptor 99D 0.0166 0.0156 0.0156
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0014 0.0014
Brugia malayi Blistered cuticle protein 3 0.0274 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni sodium/chloride dependent transporter 0.1499 0.167 0.167
Brugia malayi Cadherin domain containing protein 0.0089 0.0068 0.0068
Schistosoma mansoni notch 0.0089 0.0068 0.0068
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0046 0.1637
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0166 0.0156 0.0156
Brugia malayi hypothetical protein 0.0054 0.0028 0.0028
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0009 0.0052
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0099 0.0099
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0117 0.01 0.0601
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0166 0.0156 0.0156
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0009 0.5
Brugia malayi G-protein coupled receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.0001 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0012 0.0012
Brugia malayi G-protein coupled receptor 0.0166 0.0156 0.0156
Schistosoma mansoni amine GPCR 0.0166 0.0156 0.0156
Echinococcus multilocularis neuropeptide Y receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis chromobox protein 1 0.0069 0.0046 0.0046
Echinococcus granulosus protein jagged 2 0.0089 0.0068 0.0068
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0035 0.0212
Echinococcus granulosus peroxidasin 0.0274 0.0279 0.0279
Echinococcus granulosus chromobox protein 1 0.0069 0.0046 0.0046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0012 0.0012
Brugia malayi GCC2 and GCC3 family protein 0.0089 0.0068 0.0068
Loa Loa (eye worm) blistered cuticle protein 3 0.0274 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Onchocerca volvulus 0.0041 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Echinococcus granulosus hypothetical protein 0.0166 0.0156 0.0156
Echinococcus granulosus nAChR subunit 0.0063 0.0038 0.0038
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1499 0.167 0.167
Brugia malayi EGF-like domain containing protein 0.0089 0.0068 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Brugia malayi hypothetical protein 0.1499 0.167 0.167
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0063 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.004 0.0012 0.0012
Echinococcus granulosus jumonji domain containing protein 0.004 0.0013 0.0013
Brugia malayi Melatonin receptor type 1A 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Echinococcus multilocularis neuropeptide receptor 0.0166 0.0156 0.0156
Brugia malayi notch-like transmembrane receptor 0.0089 0.0068 0.0068
Echinococcus multilocularis neural cadherin 0.0089 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni nAChR subunit 0.0116 0.0099 0.0099
Echinococcus multilocularis fmrfamide receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.1499 0.167 0.167
Echinococcus granulosus neuropeptide s receptor 0.0166 0.0156 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0274 0.0279 0.0279
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1499 0.167 0.167
Brugia malayi G protein-coupled receptor 0.0166 0.0156 0.0156
Echinococcus granulosus alpha 1A adrenergic receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis integrin alpha ps 0.0089 0.0069 0.0069
Brugia malayi Calcium binding EGF domain containing protein 0.0089 0.0068 0.0068
Echinococcus granulosus biogenic amine 5HT receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0166 0.0156 0.0156
Brugia malayi neuropeptide F receptor 0.0166 0.0156 0.0156
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.1499 0.167 0.167
Brugia malayi hypothetical protein 0.0054 0.0028 0.0028
Onchocerca volvulus 0.0166 0.0156 0.0156
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0116 0.0099 0.0099
Brugia malayi jmjC domain containing protein 0.0035 0.0007 0.0007
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0035 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Brugia malayi putative neuropeptide receptor NPR1 0.0166 0.0156 0.0156
Brugia malayi Inositol-1 0.0037 0.0009 0.0009
Echinococcus granulosus neurogenic locus notch protein 0.0089 0.0068 0.0068
Schistosoma mansoni neurotransmitter gated ion channel 0.0054 0.0028 0.0028
Echinococcus multilocularis G protein coupled receptor 139 0.0166 0.0156 0.0156
Echinococcus multilocularis glycine receptor subunit beta 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0009 0.0009
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi EGF-like domain containing protein 0.0089 0.0068 0.0068
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0011 0.0101
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1499 0.167 0.167
Schistosoma mansoni sodium-dependent amino acid transporter 0.1499 0.167 0.167
Onchocerca volvulus 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus multilocularis integrin alpha ps 0.0089 0.0069 0.0069
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0035 1
Brugia malayi MH2 domain containing protein 0.0138 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0116 0.0099 0.0099
Echinococcus multilocularis chromobox protein 1 0.0069 0.0046 0.0046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0166 0.0156 0.0156
Echinococcus multilocularis somatostatin receptor 0.0166 0.0156 0.0156
Schistosoma mansoni septate junction protein 0.0089 0.0068 0.0068
Onchocerca volvulus 0.0166 0.0156 0.0156
Schistosoma mansoni biogenic amine receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Echinococcus granulosus fmrfamide receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis neurogenic locus protein delta 0.0089 0.0068 0.0068
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0116 0.0099 0.0099
Plasmodium vivax SET domain protein, putative 0.003 0.0001 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1499 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0116 0.0099 0.0099
Onchocerca volvulus 0.0166 0.0156 0.0156
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0099 0.0099
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1499 0.167 0.167
Schistosoma mansoni growth hormone secretagogue receptor 0.0166 0.0156 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0274 0.0279 0.0279
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0099 0.0099
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0054 0.0028 0.0028
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0116 0.0099 0.0099
Echinococcus granulosus G protein coupled receptor 139 0.0166 0.0156 0.0156
Echinococcus multilocularis sodium and chloride dependent glycine 0.1499 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.1499 0.167 0.167
Echinococcus granulosus cytochrome c oxidase subunit II 0.0168 0.0158 0.0158
Brugia malayi Tachykinin-like peptides receptor 99D 0.0166 0.0156 0.0156
Echinococcus multilocularis glycine receptor subunit beta 0.0116 0.0099 0.0099
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0166 0.0156 0.0156
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0166 0.0156 0.0156
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0051 0.0025 0.6064
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Onchocerca volvulus 0.1499 0.167 0.167
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0051 0.0025 0.0149
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Brugia malayi Animal haem peroxidase family protein 0.0274 0.0279 0.0279
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0255 0.0257 0.0257
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0035 0.0035
Echinococcus multilocularis neuropeptide s receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.1499 0.167 0.167
Echinococcus granulosus allatostatin A receptor 0.0166 0.0156 0.0156
Brugia malayi sulfakinin receptor protein 0.0166 0.0156 0.0156
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0035 0.0035
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0255 0.0257 0.0257
Onchocerca volvulus 0.0274 0.0279 0.0279
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0035 1
Loa Loa (eye worm) neuropeptide F receptor 0.0166 0.0156 0.0156
Schistosoma mansoni nAChR subunit 0.0116 0.0099 0.0099
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0089 0.0068 0.0068
Onchocerca volvulus 0.0166 0.0156 0.0156
Giardia lamblia High cysteine protein 0.0089 0.0068 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0116 0.0099 0.0099
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0051 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Schistosoma mansoni opsin-like receptor 0.0166 0.0156 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0011 0.0106
Echinococcus granulosus tm gpcr rhodopsin 0.0166 0.0156 0.0156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0019 0.0019
Schistosoma mansoni notch 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.0038 0.0038
Treponema pallidum sodium- and chloride- dependent transporter 0.8833 1 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0036 0.0008 0.0008
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1499 0.167 0.167
Echinococcus granulosus protein jagged 1 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0166 0.0156 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Onchocerca volvulus 0.0063 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1499 0.167 0.167
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0166 0.0156 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0116 0.0099 0.0099
Schistosoma mansoni opsin-like receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni integrin alpha 0.02 0.0194 0.0194
Schistosoma mansoni amine GPCR 0.0166 0.0156 0.0156
Onchocerca volvulus 0.0166 0.0156 0.0156
Echinococcus granulosus neuropeptide receptor A26 0.0166 0.0156 0.0156
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0035 0.0035
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0255 0.0257 0.0257
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0116 0.0099 0.0099
Echinococcus granulosus g-protein coupled receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0166 0.0156 0.0156
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0166 0.0156 0.0156
Echinococcus multilocularis sex peptide receptor 0.0166 0.0156 0.0156
Schistosoma mansoni neuropeptide F-like receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis protein jagged 2 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Schistosoma mansoni notch 0.0089 0.0068 0.0068
Schistosoma mansoni adenoreceptor 0.0166 0.0156 0.0156
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0166 0.0156 0.0156
Brugia malayi Heterochromatin protein 1 0.0069 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Onchocerca volvulus 0.1499 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0047 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0051 0.0025 0.6614
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1499 0.167 0.167
Onchocerca volvulus 0.0166 0.0156 0.0156
Plasmodium vivax amine transporter, putative 0.1499 0.167 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0116 0.0099 0.0099
Schistosoma mansoni nAChR subunit 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0058 0.0033 0.0033
Schistosoma mansoni amine GPCR 0.0166 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0089 0.0068 0.0068
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0166 0.0156 0.0156
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0054 0.0028 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Onchocerca volvulus 0.0166 0.0156 0.0156
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0007 0.0007
Brugia malayi G protein-coupled receptor F59B2.13 0.0166 0.0156 0.0156
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0166 0.0156 0.0156
Echinococcus multilocularis slit 2 protein 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni nAChR subunit 0.0054 0.0028 0.0028
Schistosoma mansoni neuropeptide receptor 0.0166 0.0156 0.0156
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0116 0.0099 0.0099
Loa Loa (eye worm) norepinephrine transporter 0.8833 1 1
Brugia malayi larval opioid receptor 0.0166 0.0156 0.0156
Brugia malayi Muscle positioning protein 4 0.0089 0.0068 0.0068
Echinococcus multilocularis fibropellin Ia 0.0089 0.0068 0.0068
Brugia malayi Serotonin receptor 0.0166 0.0156 0.0156
Schistosoma mansoni laminin gamma-3 chain 0.0089 0.0068 0.0068
Schistosoma mansoni myosin xvIII 0.0166 0.0156 0.0156
Onchocerca volvulus 0.003 0.0002 0.0002
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0054 0.0028 0.0028
Echinococcus granulosus somatostatin receptor 0.0166 0.0156 0.0156
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1499 0.167 0.167
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Plasmodium vivax hypothetical protein, conserved 0.1499 0.167 1
Echinococcus multilocularis protein jagged 1 0.0089 0.0068 0.0068
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0166 0.0156 0.0156
Echinococcus granulosus tm gpcr rhodopsin 0.0166 0.0156 0.0156
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0124 0.0124
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0014 0.0014
Echinococcus granulosus glycine receptor subunit beta 0.0116 0.0099 0.0099
Brugia malayi EGF-like domain containing protein 0.0089 0.0068 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0035 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.1499 0.167 0.167
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0052 0.0052
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0116 0.0099 0.0099
Echinococcus granulosus peptide allatostatin:somatostatin 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Schistosoma mansoni opsin-like receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0054 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Onchocerca volvulus Slit protein homolog 0.0089 0.0068 0.0068
Echinococcus multilocularis dro:myosuppressin receptor 0.0166 0.0156 0.0156
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0063 0.0038 0.0038
Onchocerca volvulus 0.0166 0.0156 0.0156
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0116 0.0099 0.0099
Echinococcus granulosus integrin alpha ps 0.0043 0.0016 0.0016
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni sodium/chloride dependent transporter 0.8833 1 1
Schistosoma mansoni amine GPCR 0.0166 0.0156 0.0156
Echinococcus granulosus serotonin receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0054 0.0028 0.0028
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Onchocerca volvulus Putative cubilin 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0014 0.0254
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis neuropeptide receptor A26 0.0166 0.0156 0.0156
Brugia malayi follicle stimulating hormone receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni nAChR subunit 0.0054 0.0028 0.0028
Schistosoma mansoni peroxidasin 0.0274 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni inositol monophosphatase 0.0037 0.0009 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Plasmodium falciparum amino acid transporter, putative 0.1499 0.167 1
Loa Loa (eye worm) hypothetical protein 0.1499 0.167 0.167
Echinococcus multilocularis sodium and chloride dependent glycine 0.1499 0.167 0.167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Onchocerca volvulus Chorion peroxidase homolog 0.0274 0.0279 0.0279
Brugia malayi hypothetical protein 0.0054 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1499 0.167 0.167
Loa Loa (eye worm) melatonin receptor type 1A 0.0166 0.0156 0.0156
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0166 0.0156 0.0156
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0089 0.0068 0.0068
Onchocerca volvulus 0.0116 0.0099 0.0099
Onchocerca volvulus 0.0089 0.0068 0.0068
Loa Loa (eye worm) G-protein coupled receptor 0.0166 0.0156 0.0156
Onchocerca volvulus Peroxidasin homolog 0.0274 0.0279 0.0279
Onchocerca volvulus 0.0054 0.0028 0.0028
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0035 0.0035
Brugia malayi EGF-like domain containing protein 0.0089 0.0068 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0028 0.0028
Brugia malayi hypothetical protein 0.0274 0.0279 0.0279
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0051 0.0025 0.0149
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Schistosoma mansoni acetylcholine receptor-related 0.0054 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0089 0.0068 0.0068
Brugia malayi RE15519p 0.0166 0.0156 0.0156
Brugia malayi AKH receptor 0.0166 0.0156 0.0156
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0166 0.0156 0.0156
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0054 0.0028 0.0028
Schistosoma mansoni neuropeptide receptor 0.0166 0.0156 0.0156
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1499 0.167 0.167
Schistosoma mansoni notch 0.0089 0.0068 0.0068
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0001 0.0001
Loa Loa (eye worm) ACC-1 protein 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0166 0.0156 0.0156
Onchocerca volvulus 0.0234 0.0233 0.0233
Toxoplasma gondii hypothetical protein 0.1499 0.167 1
Loa Loa (eye worm) G-protein coupled receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0116 0.0099 0.0099
Entamoeba histolytica hypothetical protein 0.0063 0.0038 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Echinococcus granulosus delta-like protein 1 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0116 0.0099 0.0099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0099 0.0099
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0054 0.0028 0.0028
Onchocerca volvulus 0.0166 0.0156 0.0156
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0116 0.0099 0.0099
Echinococcus multilocularis orexin receptor type 2 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Echinococcus granulosus sex peptide receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) animal heme peroxidase 0.0274 0.0279 0.0279
Echinococcus granulosus glycine receptor subunit alpha 1 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni biogenic amine (5HT) receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) inositol-1 0.0037 0.0009 0.0009
Schistosoma mansoni cell polarity protein 0.0089 0.0068 0.0068
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0116 0.0099 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0019 0.0019
Loa Loa (eye worm) animal heme peroxidase 0.0274 0.0279 0.0279
Onchocerca volvulus 0.0274 0.0279 0.0279
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0019 0.0019
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.1499 0.167 0.167
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0255 0.0257 0.0257
Loa Loa (eye worm) animal heme peroxidase 0.0274 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Schistosoma mansoni cytochrome c oxidase subunit II 0.0138 0.0123 0.0123
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0043 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) notch protein 0.0089 0.0068 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus multilocularis neuropeptides capa receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Onchocerca volvulus 0.0051 0.0025 0.0025
Onchocerca volvulus Neurogenic locus notch homolog 0.0089 0.0068 0.0068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.1499 0.167 0.167
Echinococcus multilocularis allatostatin A receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Loa Loa (eye worm) TYRA-2 protein 0.0166 0.0156 0.0156
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0089 0.0068 0.0068
Loa Loa (eye worm) integrin alpha pat-2 0.02 0.0194 0.0194
Echinococcus granulosus g protein coupled receptor 0.0166 0.0156 0.0156
Brugia malayi Calcium binding EGF domain containing protein 0.0089 0.0068 0.0068
Schistosoma mansoni amine GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0051 0.0025 0.0025
Schistosoma mansoni peroxidasin 0.0274 0.0279 0.0279
Onchocerca volvulus 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi EGF-like domain containing protein 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.1499 0.167 0.167
Onchocerca volvulus 0.0166 0.0156 0.0156
Echinococcus granulosus neurogenic locus notch protein 4 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni biogenic amine (5HT) receptor 0.0166 0.0156 0.0156
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0166 0.0156 0.0156
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0018 0.0018
Schistosoma mansoni notch 0.0089 0.0068 0.0068
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0019 0.0019
Schistosoma mansoni chromobox protein 0.0069 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0089 0.0068 0.0068
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.011 0.0092 0.0092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0201 0.0201
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0166 0.0156 0.0156
Brugia malayi Cation transporter family protein 0.0116 0.0099 0.0099
Onchocerca volvulus 0.0166 0.0156 0.0156
Echinococcus multilocularis peroxidasin 0.0274 0.0279 0.0279
Echinococcus granulosus neural cadherin 0.0089 0.0068 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0007 0.0007
Onchocerca volvulus 0.0116 0.0099 0.0099
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0009 0.5
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Echinococcus granulosus neurogenic locus notch protein 0.0089 0.0068 0.0068
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0166 0.0156 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Brugia malayi Cadherin domain containing protein 0.0089 0.0068 0.0068
Echinococcus granulosus integrin alpha ps 0.0089 0.0069 0.0069
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0166 0.0156 0.0156
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0255 0.0257 0.0257
Schistosoma mansoni chromobox protein 0.0069 0.0046 0.0046
Loa Loa (eye worm) neuropeptide F receptor 0.0166 0.0156 0.0156
Schistosoma mansoni nAChR subunit 0.0116 0.0099 0.0099
Onchocerca volvulus 0.0274 0.0279 0.0279
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0054 0.0028 0.0028
Onchocerca volvulus 0.1499 0.167 0.167
Onchocerca volvulus Peroxidasin homolog 0.0274 0.0279 0.0279
Brugia malayi Pre-SET motif family protein 0.0206 0.0201 0.0201
Loa Loa (eye worm) ACC-1 protein 0.0116 0.0099 0.0099
Echinococcus multilocularis g-protein coupled receptor 0.0166 0.0156 0.0156
Brugia malayi excitatory GABA receptor EXP-1A 0.0116 0.0099 0.0099
Brugia malayi Cation transporter family protein 0.0116 0.0099 0.0099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0099 0.0099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0007 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0274 0.0279 0.0279
Schistosoma mansoni neuropeptide F-like receptor 0.0166 0.0156 0.0156
Onchocerca volvulus 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0007 0.0007
Brugia malayi hypothetical protein 0.0054 0.0028 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0033 0.0033
Echinococcus granulosus dro:myosuppressin receptor 0.0166 0.0156 0.0156
Schistosoma mansoni inositol monophosphatase 0.0037 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0019 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) animal heme peroxidase 0.0274 0.0279 0.0279
Brugia malayi neuropeptide F receptor 0.0166 0.0156 0.0156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0001 0.0001
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1499 0.167 0.167
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0004 1
Echinococcus granulosus g protein coupled receptor 0.0166 0.0156 0.0156
Echinococcus granulosus sodium and chloride dependent glycine 0.1499 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0016 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Echinococcus multilocularis neurogenic locus notch protein 0.0089 0.0068 0.0068
Plasmodium falciparum transporter, putative 0.1499 0.167 1
Brugia malayi EGF-like domain containing protein 0.0089 0.0068 0.0068
Echinococcus granulosus 7TM GPCR rhodopsin 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0054 0.0028 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0019 0.0019
Onchocerca volvulus Dual oxidase homolog 0.0274 0.0279 0.0279
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0063 0.0038 0.0038
Echinococcus granulosus tm gpcr rhodopsin 0.0166 0.0156 0.0156
Loa Loa (eye worm) LGC-31 protein 0.0116 0.0099 0.0099
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0116 0.0099 0.0099
Echinococcus multilocularis fmrfamide receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.8833 1 1
Echinococcus multilocularis integrin alpha ps 0.0043 0.0016 0.0016
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Schistosoma mansoni biogenic amine receptor 0.0166 0.0156 0.0156
Schistosoma mansoni nAChR subunit 0.0116 0.0099 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0019 0.0019
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1499 0.167 1
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Schistosoma mansoni neuropeptide receptor 0.0166 0.0156 0.0156
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1499 0.167 1
Schistosoma mansoni histamine h1 receptor 0.0166 0.0156 0.0156
Onchocerca volvulus 0.0089 0.0068 0.0068
Echinococcus granulosus glycine receptor subunit beta 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0157 0.0145 0.0145
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.8833 1 1
Echinococcus multilocularis g protein coupled receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Schistosoma mansoni notch 0.0089 0.0068 0.0068
Schistosoma mansoni acetylcholine receptor subunit beta 0.0054 0.0028 0.0028
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1499 0.167 0.167
Echinococcus granulosus neurogenic locus protein delta 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0116 0.0099 0.0099
Brugia malayi ORL1-like opioid receptor 0.0166 0.0156 0.0156
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0051 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Brugia malayi Serotonin receptor 0.0166 0.0156 0.0156
Brugia malayi Pre-SET motif family protein 0.003 0.0001 0.0001
Loa Loa (eye worm) GABA receptor subunit 0.0063 0.0038 0.0038
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0075 0.0075
Echinococcus multilocularis integrin alpha 3 0.0153 0.0141 0.0141
Brugia malayi EGF-like domain containing protein 0.0089 0.0068 0.0068
Brugia malayi Dopamine receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus granulosus neuropeptide receptor 0.0166 0.0156 0.0156
Brugia malayi Delta serrate ligand family protein 0.0089 0.0068 0.0068
Schistosoma mansoni integrin alpha-ps 0.0047 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1499 0.167 0.167
Echinococcus granulosus neuropeptide Y receptor 0.0166 0.0156 0.0156
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0014 0.0254
Echinococcus multilocularis neuropeptide FF receptor 2 0.0166 0.0156 0.0156
Echinococcus multilocularis serotonin receptor 0.0166 0.0156 0.0156
Echinococcus granulosus orexin receptor type 2 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Echinococcus granulosus sodium and chloride dependent glycine 0.1499 0.167 0.167
Schistosoma mansoni slit 0.0089 0.0068 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0046 0.1637
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.003 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni neuropeptide f receptor 76f 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni neurotransmitter gated ion channel 0.0054 0.0028 0.0028
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0116 0.0099 0.0099
Echinococcus multilocularis serotonin receptor 0.0166 0.0156 0.0156
Echinococcus granulosus biogenic amine 5HT receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0255 0.0257 0.0257
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0035 1
Onchocerca volvulus 0.0166 0.0156 0.0156
Onchocerca volvulus Peroxidase homolog 0.0274 0.0279 0.0279
Brugia malayi Peroxidasin 0.0274 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Onchocerca volvulus 0.0054 0.0028 0.0028
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Schistosoma mansoni nAChR subunit 0.0116 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0014 0.0014
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Echinococcus multilocularis neurogenic locus notch protein 4 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0011 0.0101
Onchocerca volvulus 0.0166 0.0156 0.0156
Echinococcus multilocularis protein jagged 1 0.0089 0.0068 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) acetylcholine receptor protein 0.0054 0.0028 0.0028
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0001 0.0001
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni biogenic amine receptor 0.0166 0.0156 0.0156
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0255 0.0257 0.0257
Onchocerca volvulus 0.8833 1 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.1499 0.167 0.167
Schistosoma mansoni integrin alpha-ps 0.0089 0.0069 0.0069
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0046 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Brugia malayi chromobox protein homolog 3 0.0039 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0011 0.0106
Echinococcus granulosus integrin alpha 3 0.0153 0.0141 0.0141
Toxoplasma gondii hypothetical protein 0.1499 0.167 1
Brugia malayi hypothetical protein 0.0054 0.0028 0.0028
Brugia malayi Cation transporter family protein 0.0116 0.0099 0.0099
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0035 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Loa Loa (eye worm) serotonin transporter b 0.8833 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Echinococcus multilocularis neuropeptide Y receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0255 0.0257 0.0257
Echinococcus granulosus notch 0.0089 0.0068 0.0068
Onchocerca volvulus 0.0166 0.0156 0.0156
Onchocerca volvulus Putative nachr subunit 0.0255 0.0257 0.0257
Echinococcus multilocularis neuropeptides capa receptor 0.0166 0.0156 0.0156
Onchocerca volvulus 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) solute carrier family 6 member 4 0.8833 1 1
Schistosoma mansoni hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni neurotransmitter gated ion channel 0.0063 0.0038 0.0038
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0051 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0116 0.0099 0.0099
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0116 0.0099 0.0099
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0166 0.0156 0.0156
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0007 0.0007
Echinococcus granulosus glycine receptor subunit alpha 1 0.0116 0.0099 0.0099
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.1499 0.167 0.167
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Brugia malayi Integrin alpha pat-2 precursor 0.02 0.0194 0.0194
Echinococcus multilocularis g protein coupled receptor 0.0166 0.0156 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Echinococcus multilocularis serotonin transporter 0.8833 1 1
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0116 0.0099 0.0099
Echinococcus granulosus 7tm_1 domain containing protein 0.0166 0.0156 0.0156
Echinococcus granulosus serotonin transporter 0.8833 1 1
Onchocerca volvulus 0.0116 0.0099 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0274 0.0279 0.0279
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0166 0.0156 0.0156
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0116 0.0099 0.0099
Schistosoma mansoni cytochrome-c oxidase 0.0051 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.1499 0.167 0.167
Schistosoma mansoni neuropeptide receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.8833 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Echinococcus multilocularis nAChR subunit 0.0116 0.0099 0.0099
Echinococcus granulosus neuropeptide receptor 0.0166 0.0156 0.0156
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0166 0.0156 0.0156
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0166 0.0156 0.0156
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0116 0.0099 0.0099
Echinococcus granulosus chromobox protein 1 0.0069 0.0046 0.0046
Schistosoma mansoni nAChR subunit 0.0116 0.0099 0.0099
Brugia malayi hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Schistosoma mansoni alpha-1 adrenergic receptor 0.0166 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0166 0.0156 0.0156
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1499 0.167 0.167
Onchocerca volvulus 0.0063 0.0038 0.0038
Brugia malayi Dopamine receptor protein 1 0.0166 0.0156 0.0156
Onchocerca volvulus Peroxidase homolog 0.0274 0.0279 0.0279
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0013 0.0013
Onchocerca volvulus 0.0116 0.0099 0.0099
Onchocerca volvulus 0.0054 0.0028 0.0028
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0116 0.0099 0.0099
Brugia malayi jmjC domain containing protein 0.0094 0.0075 0.0075
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0054 0.0028 0.0028
Echinococcus granulosus protein jagged 1 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Brugia malayi Dopamine receptor protein 2 0.0166 0.0156 0.0156
Schistosoma mansoni sodium/chloride dependent transporter 0.1499 0.167 0.167
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0166 0.0156 0.0156
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0116 0.0099 0.0099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0166 0.0156 0.0156
Echinococcus multilocularis notch 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0054 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Echinococcus granulosus fibropellin Ia 0.0089 0.0068 0.0068
Onchocerca volvulus 0.0116 0.0099 0.0099
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0116 0.0099 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Toxoplasma gondii EGF family domain-containing protein 0.0089 0.0068 0.0406
Schistosoma mansoni hypothetical protein 0.0089 0.0068 0.0068
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0233 1
Loa Loa (eye worm) Notch2 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0166 0.0156 0.0156
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.1499 0.167 0.167
Echinococcus granulosus slit 2 protein 0.0089 0.0068 0.0068
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0168 0.0158 1
Echinococcus granulosus protein jagged 2 0.0089 0.0068 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Echinococcus multilocularis G-protein coupled receptor, putative 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0049 0.0023 0.0023
Brugia malayi putative neuropeptide receptor 0.0166 0.0156 0.0156
Brugia malayi GnHR receptor homolog 0.0166 0.0156 0.0156
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0255 0.0257 0.0257
Schistosoma mansoni hypothetical protein 0.0043 0.0016 0.0016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0001 0.0005
Echinococcus multilocularis neuropeptide receptor 0.0166 0.0156 0.0156
Echinococcus granulosus neuropeptide FF receptor 2 0.0166 0.0156 0.0156
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0054 0.0028 0.0028
Echinococcus granulosus neuropeptide Y receptor 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0089 0.0068 0.0068
Echinococcus multilocularis neurogenic locus notch protein 0.0089 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0274 0.0279 0.0279
Echinococcus granulosus nAChR subunit 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0116 0.0099 0.0099
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1499 0.167 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.0156 0.0156
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0124 0.0124
Onchocerca volvulus Neuropeptide F receptor homolog 0.0166 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0068 0.0068
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0116 0.0099 0.0099
Echinococcus granulosus glycine receptor subunit alpha 1 0.0116 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.1416 0.1575 0.1575
Echinococcus granulosus rhodopsin orphan GPCR 0.0166 0.0156 0.0156
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0116 0.0099 0.0099

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.03 ug ml-1 In Vitro antibacterial activity against (Ec) E. coli ATCC 25922 ChEMBL. 7473551
MIC (functional) = 0.03 ug ml-1 In Vitro antibacterial activity against (Ec L) E. coli Beta-lactam lacking strain ChEMBL. 7473551
MIC (functional) = 0.03 ug ml-1 In Vitro antibacterial activity against (Ec) E. coli ATCC 25922 ChEMBL. 7473551
MIC (functional) = 0.03 ug ml-1 In Vitro antibacterial activity against (Ec L) E. coli Beta-lactam lacking strain ChEMBL. 7473551
MIC (functional) = 0.06 ug ml-1 In Vitro antibacterial activity against (Pa G242) hyperpermeable P. aeruginosa strain ChEMBL. 7473551
MIC (functional) = 0.12 ug ml-1 In vitro antibacterial activity against Sa(I) S. aureus ATCC 29213 ChEMBL. 7473551
MIC (functional) = 0.12 ug ml-1 In vitro antibacterial activity against Sa(II) S. aureus ATCC 25923 ChEMBL. 7473551
MIC (functional) = 0.12 ug ml-1 In Vitro antibacterial activity against (Ec DC2) hyperpermeable E. coli strain ChEMBL. 7473551
MIC (functional) = 0.12 ug ml-1 In Vitro antibacterial activity against (Ec TEM1) E. coli Beta-lactam producting strain ChEMBL. 7473551
MIC (functional) = 0.12 ug ml-1 In Vitro antibacterial activity against (Ec DC2) hyperpermeable E. coli strain ChEMBL. 7473551
MIC (functional) = 0.12 ug ml-1 In Vitro antibacterial activity against (Ec TEM1) E. coli Beta-lactam producting strain ChEMBL. 7473551
MIC (functional) = 0.2 ug ml-1 In Vitro antibacterial activity against (Pa) hyperpermeable P. aeruginosa Beta-lactam lacking strain ChEMBL. 7473551
MIC (functional) = 0.25 ug ml-1 In vitro antibacterial activity against Sa MR(I) heterogeneous methicillin resistant S. aureus ChEMBL. 7473551
MIC (functional) = 0.25 ug ml-1 In Vitro antibacterial activity against (Ec TEM2) E. coli Beta-lactam producting strain ChEMBL. 7473551
MIC (functional) = 0.25 ug ml-1 In Vitro antibacterial activity against (Ec SHV) E. coli Beta-lactam producting strain ChEMBL. 7473551
MIC (functional) = 0.25 ug ml-1 In Vitro antibacterial activity against (Ec TEM2) E. coli Beta-lactam producting strain ChEMBL. 7473551
MIC (functional) = 0.25 ug ml-1 In Vitro antibacterial activity against (Ec SHV) E. coli Beta-lactam producting strain ChEMBL. 7473551
MIC (functional) = 2 ug ml-1 In Vitro antibacterial activity against (Ef) E. faecalis ATCC 29212 ChEMBL. 7473551
MIC (functional) = 8 ug ml-1 In vitro antibacterial activity against Sa MR(II) homogeneous methicillin resistant S. aureus ChEMBL. 7473551
MIC (functional) > 64 ug ml-1 In Vitro antibacterial activity against (Pa) P. aeruginosa ATCC 27853 ChEMBL. 7473551
MIC90 (functional) = 0.015 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of E. coli ChEMBL. 7473551
MIC90 (functional) = 0.015 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of E. coli ChEMBL. 7473551
MIC90 (functional) = 0.03 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Streptococcus pyogenes(31) ChEMBL. 7473551
MIC90 (functional) = 0.03 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Streptococcus pneumoniae (23) ChEMBL. 7473551
MIC90 (functional) = 0.06 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Streptococcus agalactiaeB(21) ChEMBL. 7473551
MIC90 (functional) = 0.12 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of S. aureus MS (6) ChEMBL. 7473551
MIC90 (functional) = 0.12 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Listeria monocytogenes(20) ChEMBL. 7473551
MIC90 (functional) = 0.15 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Yersinia species(20) ChEMBL. 7473551
MIC90 (functional) = 0.25 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Clostridium perfringens(27) ChEMBL. 7473551
MIC90 (functional) = 0.5 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Klebsiella pneumoniae(20) ChEMBL. 7473551
MIC90 (functional) = 1 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of S. epidermidis (13) ChEMBL. 7473551
MIC90 (functional) = 1 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Branhamella catarrhalis(27) ChEMBL. 7473551
MIC90 (functional) = 1 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Citrobacter freundii(20) ChEMBL. 7473551
MIC90 (functional) = 2 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Aeromonas species(21) ChEMBL. 7473551
MIC90 (functional) = 4 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Haemophilus Influenzae(21) ChEMBL. 7473551
MIC90 (functional) = 4 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Proteus mirabilis(16) ChEMBL. 7473551
MIC90 (functional) = 4 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Proteus vulgaris(10) ChEMBL. 7473551
MIC90 (functional) = 4 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Providencia rettgeri(10) ChEMBL. 7473551
MIC90 (functional) = 4 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Providencia stuartii(10) ChEMBL. 7473551
MIC90 (functional) = 8 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Enterococcus faecalis(47) ChEMBL. 7473551
MIC90 (functional) = 8 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Morganella morganii(10) ChEMBL. 7473551
MIC90 (functional) = 16 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Acinetobacter anitratus(20) ChEMBL. 7473551
MIC90 (functional) = 16 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Enterobacter aerogenes(19) ChEMBL. 7473551
MIC90 (functional) > 32 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of S. aureus MV (20) ChEMBL. 7473551
MIC90 (functional) = 32 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Bacteroides fragilis(15) ChEMBL. 7473551
MIC90 (functional) > 64 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Enterococcus faecium(47) ChEMBL. 7473551
MIC90 (functional) > 64 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Pseudomonas aeruginosa(11) ChEMBL. 7473551
MIC90 (functional) > 64 ug ml-1 In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Xanthomonas maltophilia(9) ChEMBL. 7473551

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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