Detailed information for compound 246881

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 899.071 | Formula: C49H70O15
  • H donors: 0 H acceptors: 3 LogP: 9.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1OC2OC3(C)CCC4C2(C(C1CCCCCCC1(CC2C(=O)OC5C67C2CCC(C7CCC(O5)(OO6)C)C)C(=O)OC2C56C1CCC(C6CCC(O2)(OO5)C)C)CCC4C)OO3
  • InChi: 1S/C49H70O15/c1-26-12-15-34-29(37(50)53-40-47(34)31(26)18-22-43(4,56-40)59-62-47)11-9-7-8-10-21-46(36-17-14-28(3)33-20-24-45(6)58-42(55-39(46)52)49(33,36)64-61-45)25-30-35-16-13-27(2)32-19-23-44(5)57-41(54-38(30)51)48(32,35)63-60-44/h26-36,40-42H,7-25H2,1-6H3
  • InChiKey: VFLZQZBJXDIHSH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major geranylgeranyltransferase, putative 0.00411321 0.0258561 0.0701122
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.00292631 0.015045 0.020436
Echinococcus multilocularis g protein coupled receptor 0.00865019 0.0671823 0.121219
Leishmania major methionine aminopeptidase 2, putative 0.00851103 0.0659147 0.204421
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Echinococcus granulosus tm gpcr rhodopsin 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Plasmodium vivax methionine aminopeptidase 2, putative 0.00851103 0.0659147 0.117964
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0109616 0.088236 0.291014
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0852771
Loa Loa (eye worm) hypothetical protein 0.00411321 0.0258561 0.0413342
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00865019 0.0671823 0.121219
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.00411321 0.0258561 0.0413342
Plasmodium falciparum telomerase reverse transcriptase 0.0345615 0.303201 0.577066
Echinococcus multilocularis methionyl aminopeptidase 2 0.00851103 0.0659147 0.118769
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trichomonas vaginalis meiosis-specific recA homolog Dmc1 0.00218767 0.00831696 0.00821943
Brugia malayi Doublecortin family protein 0.00204943 0.00705775 0.00379711
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) guanylate kinase 0.00246572 0.0108497 0.0123263
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus protein farnesyltransferase subunit beta 0.00411321 0.0258561 0.0413342
Toxoplasma gondii aurora kinase 0.00575387 0.0408004 0.0870167
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0030107 0.0158137 0.0521556
Echinococcus granulosus g protein coupled receptor 0.00865019 0.0671823 0.121219
Brugia malayi metallopeptidase family M24 containing protein 0.00292631 0.015045 0.0155307
Trypanosoma brucei Metallopeptidase family M24, putative 0.00292631 0.015045 0.0496205
Echinococcus granulosus ATPase H transporting lysosomal accessory 0.03498 0.307013 0.584818
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.00181745 0.0049447 0.00091181
Trichomonas vaginalis PIKK family atypical protein kinase 0.00178184 0.00462038 0.00107951
Echinococcus multilocularis sterol O acyltransferase 1 0.0124457 0.101755 0.188049
Echinococcus granulosus dro:myosuppressin receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis lipoxygenase domain containing protein 0.00204943 0.00705775 0.00499641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni lipoxygenase 0.00790373 0.0603829 0.108076
Onchocerca volvulus 0.00292631 0.015045 0.0106195
Loa Loa (eye worm) hypothetical protein 0.00181745 0.0049447 0.00091181
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.00292631 0.015045 0.020436
Trypanosoma brucei hypothetical protein, conserved 0.0109616 0.088236 0.291014
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.00851103 0.0659147 0.0617177
Loa Loa (eye worm) initiation factor 2-associated protein 0.00851103 0.0659147 0.118769
Echinococcus granulosus FACT complex subunit SPT16 0.00292631 0.015045 0.020436
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Echinococcus granulosus microsomal glutathione S transferase 3 0.0116319 0.0943417 0.173719
Echinococcus multilocularis FACT complex subunit SPT16 0.00292631 0.015045 0.020436
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.00181745 0.0049447 0.00091181
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00172403 0.0040938 0.0000624165
Echinococcus granulosus Proliferation associated protein 2G4 0.00292631 0.015045 0.020436
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00865019 0.0671823 0.0921226
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.00292631 0.015045 0.019542
Onchocerca volvulus 0.00204943 0.00705775 0.00259637
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) G-protein coupled receptor 0.00865019 0.0671823 0.121219
Brugia malayi Serotonin receptor 0.00865019 0.0671823 0.0921226
Giardia lamblia Prenyltransferase 0.00411321 0.0258561 0.0413342
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) STAT protein 0.0312888 0.273391 0.519827
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Schistosoma mansoni alpha-1 adrenergic receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni opsin-like receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni biogenic amine (5HT) receptor 0.00865019 0.0671823 0.121219
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.00243765 0.0105939 0.0189408
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00865019 0.0671823 0.121219
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.018906 0.1606 0.646597
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.00181745 0.0049447 0.00091181
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0109616 0.088236 0.161916
Trypanosoma cruzi hypothetical protein, conserved 0.0109616 0.088236 0.27926
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00865019 0.0671823 0.121219
Leishmania major telomerase reverse transcriptase, putative 0.0345615 0.303201 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0404593
Schistosoma mansoni microsomal glutathione s-transferase 0.0116319 0.0943417 0.173719
Plasmodium falciparum aminopeptidase P 0.00292631 0.015045 0.019542
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.018906 0.1606 0.52968
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0496205
Plasmodium vivax telomerase reverse transcriptase, putative 0.0345615 0.303201 0.577066
Brugia malayi STAT protein, DNA binding domain containing protein 0.0312888 0.273391 0.395052
Onchocerca volvulus 0.0109616 0.088236 0.0841394
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00865019 0.0671823 0.121219
Trypanosoma cruzi Metallopeptidase family M24, putative 0.00292631 0.015045 0.0338645
Echinococcus granulosus o acyltransferase membrane bound domain 0.00181745 0.0049447 0.00091181
Onchocerca volvulus Peroxidase homolog 0.00546514 0.0381705 0.0338489
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.00575387 0.0408004 0.0693735
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Echinococcus granulosus biogenic amine 5HT receptor 0.00865019 0.0671823 0.121219
Mycobacterium leprae conserved hypothetical protein 0.00676103 0.0499744 0.155167
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00186815 0.00540653 0.00259794
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Trichomonas vaginalis AGC family protein kinase 0.00575387 0.0408004 0.0709611
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00865019 0.0671823 0.121219
Brugia malayi ORL1-like opioid receptor 0.00865019 0.0671823 0.0921226
Chlamydia trachomatis transcriptional repressor NrdR 0.00676103 0.0499744 0.121835
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.00411321 0.0258561 0.0420962
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00851103 0.0659147 0.119469
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00865019 0.0671823 0.121219
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0420962
Echinococcus multilocularis methionine aminopeptidase, type I 0.00292631 0.015045 0.020436
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis fmrfamide receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis AGC family protein kinase 0.00444775 0.0289034 0.0479821
Plasmodium vivax multidomain scavenger receptor, putative 0.00204943 0.00705775 0.00408833
Schistosoma mansoni serine/threonine protein kinase 0.00575387 0.0408004 0.0702221
Brugia malayi Methionine aminopeptidase protein type I 0.018906 0.1606 0.229357
Loa Loa (eye worm) AUR protein kinase 0.00575387 0.0408004 0.0702221
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.00411321 0.0258561 0.0413342
Loa Loa (eye worm) latrophilin receptor protein 2 0.00935842 0.0736333 0.133689
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Trypanosoma brucei target of rapamycin kinase 3, putative 0.00243765 0.0105939 0.0349403
Trichomonas vaginalis PIKK family atypical protein kinase 0.00199531 0.00656477 0.00483507
Trichomonas vaginalis conserved hypothetical protein 0.00181745 0.0049447 0.00170592
Brugia malayi hypothetical protein 0.03498 0.307013 0.444444
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Echinococcus granulosus g protein coupled receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis conserved hypothetical protein 0.00181745 0.0049447 0.00170592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.018906 0.1606 0.646597
Trichomonas vaginalis PIKK family atypical protein kinase 0.00178184 0.00462038 0.00107951
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0030107 0.0158137 0.0364416
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) AUR protein kinase 0.00575387 0.0408004 0.0702221
Leishmania major hypothetical protein, conserved 0.00292631 0.015045 0.0338645
Loa Loa (eye worm) G-protein coupled receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis G protein coupled receptor 139 0.00865019 0.0671823 0.121219
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Brugia malayi larval opioid receptor 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.018906 0.1606 0.301798
Trypanosoma cruzi target of rapamycin kinase 3 0.00243765 0.0105939 0.0189408
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00865019 0.0671823 0.0921226
Trichomonas vaginalis AGC family protein kinase 0.00575387 0.0408004 0.0709611
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.00292631 0.015045 0.020436
Brugia malayi Latrophilin receptor protein 2 0.00935842 0.0736333 0.101599
Trichomonas vaginalis CMGC family protein kinase 0.00439274 0.0284024 0.0470142
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0344009 0.301738 0.995094
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus aurora kinase A 0.00575387 0.0408004 0.0702221
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0295772 0.257801 0.372149
Trypanosoma brucei glycerol uptake protein, putative 0.00181745 0.0049447 0.0163083
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus tachykinin peptides receptor 99D 0.00865019 0.0671823 0.121219
Entamoeba histolytica protein kinase , putative 0.00575387 0.0408004 0.0693735
Echinococcus multilocularis dna repair protein rad51 1 0.00218767 0.00831696 0.0074305
Echinococcus granulosus sex peptide receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis Proliferation associated protein 2G4 0.00292631 0.015045 0.020436
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.00181745 0.0049447 0.00091181
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.00411321 0.0258561 0.0314127
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Echinococcus multilocularis g protein coupled receptor 0.00865019 0.0671823 0.121219
Brugia malayi RE15519p 0.00865019 0.0671823 0.0921226
Schistosoma mansoni cell polarity protein 0.00269421 0.0129309 0.0163493
Echinococcus multilocularis allatostatin A receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.00181745 0.0049447 0.00091181
Plasmodium falciparum protein farnesyltransferase subunit beta 0.00411321 0.0258561 0.0404593
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00444775 0.0289034 0.0472248
Entamoeba histolytica protein kinase domain containing protein 0.00575387 0.0408004 0.0693735
Giardia lamblia Kinase, CMGC CDK 0.00439274 0.0284024 0.0462562
Giardia lamblia Methionine aminopeptidase 0.00851103 0.0659147 0.118769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0030107 0.0158137 0.0226993
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0585599 0.521795 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00865019 0.0671823 0.121219
Brugia malayi G protein-coupled receptor 0.00865019 0.0671823 0.0921226
Schistosoma mansoni hypothetical protein 0.00935842 0.0736333 0.133689
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.00575387 0.0408004 0.0693735
Loa Loa (eye worm) MBOAT family protein 0.00181745 0.0049447 0.00091181
Schistosoma mansoni biogenic amine receptor 0.00865019 0.0671823 0.121219
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0344009 0.301738 0.436695
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.00181745 0.0049447 0.00091181
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0030107 0.0158137 0.0364416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.00411321 0.0258561 0.0404593
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Brugia malayi G-protein coupled receptor 0.00865019 0.0671823 0.0921226
Echinococcus granulosus 7tm_1 domain containing protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni loxhd1 0.00204943 0.00705775 0.00499641
Echinococcus granulosus g protein coupled receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) TYRA-2 protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00865019 0.0671823 0.121219
Trypanosoma cruzi aminopeptidase P1, putative 0.00292631 0.015045 0.0338645
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0109616 0.088236 0.291014
Echinococcus multilocularis G-protein coupled receptor, putative 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00292631 0.015045 0.020436
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.00439274 0.0284024 0.0462562
Leishmania major farnesyltransferase beta subunit 0.00411321 0.0258561 0.0701122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.00935842 0.0736333 0.101599
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0030107 0.0158137 0.0210292
Schistosoma mansoni protein kinase 0.00575387 0.0408004 0.0702221
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00865019 0.0671823 0.121219
Brugia malayi metallopeptidase family M24 containing protein 0.00292631 0.015045 0.0155307
Echinococcus multilocularis neuropeptide Y receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0420962
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0368879 0.324392 0.618413
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0276399 0.240154 1
Trypanosoma brucei telomerase reverse transcriptase 0.0345615 0.303201 1
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0585599 0.521795 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) doublecortin family protein 0.00204943 0.00705775 0.00499641
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.00292631 0.015045 0.020436
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0344009 0.301738 0.995174
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0345615 0.303201 1
Loa Loa (eye worm) melatonin receptor type 1A 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) methionine aminopeptidase type I 0.018906 0.1606 0.301798
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.00851103 0.0659147 0.118769
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0030107 0.0158137 0.0219218
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.00181745 0.0049447 0.00091181
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis neuropeptide Y receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.00411321 0.0258561 0.0413342
Loa Loa (eye worm) diacylglycerol acyltransferase 0.00181745 0.0049447 0.00091181
Trypanosoma cruzi protein farnesyltransferase, putative 0.00411321 0.0258561 0.0701122
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.00444775 0.0289034 0.0472248
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Schistosoma mansoni serine/threonine protein kinase 0.00439274 0.0284024 0.0462562
Schistosoma mansoni sterol O-acyltransferase 1 0.0124457 0.101755 0.188049
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.00676103 0.0499744 0.155167
Schistosoma mansoni neuropeptide receptor 0.00865019 0.0671823 0.121219
Brugia malayi initiation factor 2-associated protein. 0.00851103 0.0659147 0.0902604
Trypanosoma brucei aurora B kinase 0.00575387 0.0408004 0.134565
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Onchocerca volvulus 0.00181745 0.0049447 0.000473819
Loa Loa (eye worm) animal heme peroxidase 0.00546514 0.0381705 0.0651384
Echinococcus multilocularis disks large 3 0.00269421 0.0129309 0.0163493
Echinococcus multilocularis neuropeptide s receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus sterol O acyltransferase 1 0.0124457 0.101755 0.188049
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) animal heme peroxidase 0.00546514 0.0381705 0.0651384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.00845661 0.065419 0.202759
Loa Loa (eye worm) MBOAT family protein 0.00181745 0.0049447 0.00091181
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0585599 0.521795 1
Schistosoma mansoni hypothetical protein 0.0202188 0.172558 0.324912
Brugia malayi hypothetical protein 0.00204943 0.00705775 0.00379711
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0030107 0.0158137 0.0210292
Brugia malayi Protein kinase domain containing protein 0.00444775 0.0289034 0.0358893
Schistosoma mansoni hypothetical protein 0.00204943 0.00705775 0.00499641
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00249901 0.0111528 0.0136969
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.00292631 0.015045 0.0338645
Trypanosoma cruzi aminopeptidase P, putative 0.00292631 0.015045 0.0338645
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus neuropeptide Y receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus cyclin dependent kinase 0.00439274 0.0284024 0.0462562
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.00181745 0.0049447 0.00091181
Plasmodium falciparum methionine aminopeptidase 2 0.00851103 0.0659147 0.117964
Giardia lamblia Kinase, CMGC CDK 0.00439274 0.0284024 0.0462562
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.00411321 0.0258561 0.0404593
Toxoplasma gondii methionine aminopeptidase 0.018906 0.1606 0.373978
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00426948 0.0272796 0.0440859
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00292631 0.015045 0.020436
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0585599 0.521795 1
Entamoeba histolytica peptidase, putative 0.00292631 0.015045 0.019542
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.00292631 0.015045 0.0253236
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.00292631 0.015045 0.020436
Echinococcus granulosus tm gpcr rhodopsin 0.00865019 0.0671823 0.121219
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.018906 0.1606 0.301798
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Trichomonas vaginalis PIKK family atypical protein kinase 0.00172403 0.0040938 0.0000624165
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Plasmodium falciparum FACT complex subunit SPT16, putative 0.00292631 0.015045 0.019542
Entamoeba histolytica hypothetical protein, conserved 0.00292631 0.015045 0.019542
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.00411321 0.0258561 0.05122
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0276399 0.240154 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Trypanosoma cruzi cdc2-related kinase 1 0.00439274 0.0284024 0.0786492
Plasmodium falciparum serine/threonine protein kinase, putative 0.00575387 0.0408004 0.0693735
Echinococcus granulosus disks large 3 0.00269421 0.0129309 0.0163493
Schistosoma mansoni hypothetical protein 0.00935842 0.0736333 0.133689
Toxoplasma gondii MAPEG family protein 0.0116319 0.0943417 0.215266
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Schistosoma mansoni hypothetical protein 0.00935842 0.0736333 0.133689
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.00292631 0.015045 0.019542
Echinococcus granulosus peroxidasin 0.00546514 0.0381705 0.0651384
Brugia malayi diacylglycerol acyltransferase 0.00181745 0.0049447 0.000692947
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus g-protein coupled receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0295772 0.257801 0.48969
Giardia lamblia Xaa-Pro dipeptidase 0.00292631 0.015045 0.020436
Brugia malayi Calcitonin receptor-like protein seb-1 0.0295772 0.257801 0.372149
Trichomonas vaginalis conserved hypothetical protein 0.00181745 0.0049447 0.00170592
Brugia malayi Dopamine receptor protein 1 0.00865019 0.0671823 0.0921226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Plasmodium vivax peptidase, putative 0.00292631 0.015045 0.019542
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0109616 0.088236 0.123051
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.018906 0.1606 0.373978
Echinococcus granulosus RUN 0.00204943 0.00705775 0.00499641
Schistosoma mansoni myosin xvIII 0.00865019 0.0671823 0.121219
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0496205
Loa Loa (eye worm) phosphatidylinositol 3 0.0030107 0.0158137 0.0219218
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Echinococcus multilocularis neuropeptides capa receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Schistosoma mansoni hypothetical protein 0.00865019 0.0671823 0.121219
Trichomonas vaginalis AGC family protein kinase 0.00575387 0.0408004 0.0709611
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0368879 0.324392 0.618065
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Brugia malayi Dopamine receptor 0.00865019 0.0671823 0.0921226
Echinococcus granulosus allatostatin A receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00935842 0.0736333 0.133689
Mycobacterium ulcerans methionine aminopeptidase MapB 0.018906 0.1606 0.646597
Loa Loa (eye worm) animal heme peroxidase 0.00546514 0.0381705 0.0651384
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Trypanosoma cruzi DNA repair protein RAD51, putative 0.00218767 0.00831696 0.0113066
Onchocerca volvulus Peroxidasin homolog 0.00546514 0.0381705 0.0338489
Echinococcus multilocularis peroxidasin 0.00546514 0.0381705 0.0651384
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) blistered cuticle protein 3 0.00546514 0.0381705 0.0651384
Loa Loa (eye worm) hhat protein 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis lipoxygenase domain containing protein 0.00204943 0.00705775 0.00499641
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00851103 0.0659147 0.119469
Giardia lamblia GTOR 0.0030107 0.0158137 0.0219218
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00439274 0.0284024 0.0462562
Echinococcus granulosus hypothetical protein 0.00865019 0.0671823 0.121219
Entamoeba histolytica cell division protein kinase 2, putative 0.00439274 0.0284024 0.0453857
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.00181745 0.0049447 0.00091181
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi phosphoinositide-dependent protein kinase I 0.00444775 0.0289034 0.0358893
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0368879 0.324392 0.618413
Plasmodium vivax serine/threonine protein kinase 6, putative 0.00575387 0.0408004 0.0693735
Entamoeba histolytica methionine aminopeptidase, putative 0.00851103 0.0659147 0.117964
Echinococcus granulosus serotonin receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus neuropeptide FF receptor 2 0.00865019 0.0671823 0.121219
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Plasmodium vivax proliferation-associated protein 2g4, putative 0.00292631 0.015045 0.019542
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.00411321 0.0258561 0.0413342
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Brugia malayi putative neuropeptide receptor NPR1 0.00865019 0.0671823 0.0921226
Echinococcus granulosus xaa Pro dipeptidase 0.00292631 0.015045 0.020436
Schistosoma mansoni neuropeptide receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus cyclin dependent kinase 5 0.00439274 0.0284024 0.0462562
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi Blistered cuticle protein 3 0.00546514 0.0381705 0.0495031
Echinococcus granulosus serine:threonine protein kinase 12 B 0.00575387 0.0408004 0.0702221
Loa Loa (eye worm) hypothetical protein 0.0124457 0.101755 0.188049
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni zinc finger protein 0.00181745 0.0049447 0.00091181
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Onchocerca volvulus 0.00546514 0.0381705 0.0338489
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Echinococcus multilocularis xaa pro aminopeptidase 0.00292631 0.015045 0.020436
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.00935842 0.0736333 0.133689
Echinococcus multilocularis neuropeptide receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00865019 0.0671823 0.121219
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0030107 0.0158137 0.0521556
Trichomonas vaginalis PIKK family atypical protein kinase 0.00192951 0.00596543 0.00367746
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.00444775 0.0289034 0.0472248
Echinococcus multilocularis fmrfamide receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus GPCR family 2 0.00935842 0.0736333 0.133689
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115927 0.0939847 0.173029
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus lipoxygenase domain containing protein 0.00204943 0.00705775 0.00499641
Echinococcus granulosus xaa pro aminopeptidase 0.00292631 0.015045 0.020436
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0030107 0.0158137 0.0364416
Trypanosoma cruzi lanosterol synthase, putative 0.00411321 0.0258561 0.0701122
Echinococcus multilocularis g-protein coupled receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus neuropeptide receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00865019 0.0671823 0.121219
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0314127
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0344009 0.301738 0.574623
Echinococcus granulosus peptide allatostatin:somatostatin 0.00865019 0.0671823 0.121219
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0109616 0.088236 0.161916
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.00997637 0.079262 0.285271
Schistosoma mansoni serine/threonine protein kinase 0.00439274 0.0284024 0.0462562
Schistosoma mansoni hypothetical protein 0.00935842 0.0736333 0.133689
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni serine/threonine protein kinase 0.00444775 0.0289034 0.0472248
Schistosoma mansoni hypothetical protein 0.00865019 0.0671823 0.121219
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.018906 0.1606 0.301161
Echinococcus granulosus methionine aminopeptidase type I 0.00292631 0.015045 0.020436
Plasmodium vivax protein kinase Crk2 0.00439274 0.0284024 0.0453857
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0344009 0.301738 0.574234
Trypanosoma cruzi DNA repair protein RAD51, putative 0.00218767 0.00831696 0.0113066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00865019 0.0671823 0.121219
Echinococcus multilocularis aurora kinase A 0.00575387 0.0408004 0.0702221
Echinococcus granulosus orexin receptor type 2 0.00865019 0.0671823 0.121219
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00865019 0.0671823 0.121219
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.00292631 0.015045 0.0338645
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Toxoplasma gondii hypothetical protein 0.0109616 0.088236 0.200641
Echinococcus granulosus lysophospholipid acyltransferase 7 0.00181745 0.0049447 0.00091181
Trichomonas vaginalis AGC family protein kinase 0.00444775 0.0289034 0.0479821
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0030107 0.0158137 0.0219218
Schistosoma mansoni peroxidasin 0.00546514 0.0381705 0.0651384
Brugia malayi AKH receptor 0.00865019 0.0671823 0.0921226
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0585599 0.521795 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.00935842 0.0736333 0.133689
Leishmania major transcription factor-like protein 0.00292631 0.015045 0.0338645
Loa Loa (eye worm) hypothetical protein 0.00181745 0.0049447 0.00091181
Entamoeba histolytica protein kinase, putative 0.00444775 0.0289034 0.0463552
Echinococcus granulosus cyclin dependent kinase 1 0.00439274 0.0284024 0.0462562
Schistosoma mansoni DNA repair protein RAD51 0.00218767 0.00831696 0.0074305
Echinococcus granulosus o acyltransferase membrane bound domain 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis cyclin dependent kinase 5 0.00439274 0.0284024 0.0462562
Loa Loa (eye worm) hypothetical protein 0.00204943 0.00705775 0.00499641
Toxoplasma gondii peptidase D, putative 0.00292631 0.015045 0.0253236
Plasmodium vivax FACT complex subunit SPT16, putative 0.00292631 0.015045 0.019542
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Trypanosoma brucei cdc2-related kinase 1 0.00439274 0.0284024 0.0936748
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.018906 0.1606 0.521883
Trichomonas vaginalis AGC family protein kinase 0.00575387 0.0408004 0.0709611
Loa Loa (eye worm) hypothetical protein 0.0585599 0.521795 1
Giardia lamblia Aurora kinase 0.00575387 0.0408004 0.0702221
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.00411321 0.0258561 0.05122
Echinococcus multilocularis sex peptide receptor 0.00865019 0.0671823 0.121219
Brugia malayi Melatonin receptor type 1A 0.00865019 0.0671823 0.0921226
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Echinococcus granulosus Polycystic kidney disease protein 0.00204943 0.00705775 0.00499641
Trypanosoma brucei cdc2-related kinase 3 0.00439274 0.0284024 0.0936748
Schistosoma mansoni adenoreceptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus tm gpcr rhodopsin 0.00865019 0.0671823 0.121219
Trypanosoma cruzi cdc2-related kinase 3 0.00439274 0.0284024 0.0786492
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.00851103 0.0659147 0.217396
Loa Loa (eye worm) hypothetical protein 0.00292631 0.015045 0.020436
Brugia malayi GnHR receptor homolog 0.00865019 0.0671823 0.0921226
Brugia malayi Protein kinase domain containing protein 0.00439274 0.0284024 0.0351532
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus neuropeptide s receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.0295772 0.257801 0.48969
Echinococcus multilocularis GPCR, family 2 0.00935842 0.0736333 0.133689
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0276399 0.240154 0.456011
Trypanosoma brucei protein farnesyltransferase beta subunit 0.00411321 0.0258561 0.0852771
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.00575387 0.0408004 0.0702221
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.00439274 0.0284024 0.0462562
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00865019 0.0671823 0.121219
Entamoeba histolytica protein kinase, putative 0.00575387 0.0408004 0.0693735
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00865019 0.0671823 0.121219
Giardia lamblia Xaa-Pro dipeptidase 0.00292631 0.015045 0.020436
Schistosoma mansoni opsin-like receptor 0.00865019 0.0671823 0.121219
Chlamydia trachomatis methionine aminopeptidase 0.018906 0.1606 0.507702
Echinococcus multilocularis serotonin receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0109616 0.088236 0.161916
Echinococcus multilocularis neuropeptide receptor A26 0.00865019 0.0671823 0.121219
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.00181745 0.0049447 0.00112988
Echinococcus granulosus biogenic amine 5HT receptor 0.00865019 0.0671823 0.121219
Brugia malayi putative neuropeptide receptor 0.00865019 0.0671823 0.0921226
Schistosoma mansoni neuropeptide f receptor 76f 0.00865019 0.0671823 0.121219
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.27926
Schistosoma mansoni rab6-interacting 0.00204943 0.00705775 0.00499641
Plasmodium falciparum LCCL domain-containing protein 0.00204943 0.00705775 0.00408833
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0344009 0.301738 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.018906 0.1606 0.646597
Trypanosoma brucei methionine aminopeptidase, putative 0.018906 0.1606 0.52968
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0368879 0.324392 0.469974
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00865019 0.0671823 0.121219
Mycobacterium ulcerans methionine aminopeptidase 0.018906 0.1606 0.646597
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.018906 0.1606 0.646597
Toxoplasma gondii hypothetical protein 0.00181745 0.0049447 0.00112988
Brugia malayi Tachykinin-like peptides receptor 99D 0.00865019 0.0671823 0.0921226
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0585599 0.521795 0.759969
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni lipoxygenase 0.0115927 0.0939847 0.173029
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.05122
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis xaa Pro dipeptidase 0.00292631 0.015045 0.020436
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.00218767 0.00831696 0.0113066
Toxoplasma gondii methionine aminopeptidase 0.018906 0.1606 0.373978
Echinococcus granulosus lipoxygenase domain containing protein 0.00204943 0.00705775 0.00499641
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0109616 0.088236 0.161916
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.00181745 0.0049447 0.00091181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00204943 0.00705775 0.00499641
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Schistosoma mansoni neuropeptide receptor 0.00865019 0.0671823 0.121219
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0109616 0.088236 0.161152
Onchocerca volvulus Dipeptidase C homolog 0.00292631 0.015045 0.0106195
Trichomonas vaginalis CMGC family protein kinase 0.00439274 0.0284024 0.0470142
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00865019 0.0671823 0.121219
Echinococcus granulosus neuropeptide receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni polycystin 1-related 0.00204943 0.00705775 0.00499641
Trypanosoma cruzi protein farnesyltransferase, putative 0.00411321 0.0258561 0.0701122
Echinococcus granulosus alpha 1A adrenergic receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus 7TM GPCR rhodopsin 0.00865019 0.0671823 0.121219
Trichomonas vaginalis AGC family protein kinase 0.00444775 0.0289034 0.0479821
Schistosoma mansoni biogenic amine (5HT) receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00865019 0.0671823 0.121219
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.00292631 0.015045 0.020436
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.00439274 0.0284024 0.0786492
Loa Loa (eye worm) hypothetical protein 0.03498 0.307013 0.584818
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.018906 0.1606 0.521883
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Treponema pallidum aminopeptidase P 0.00292631 0.015045 0.0340314
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trichomonas vaginalis CMGC family protein kinase 0.00439274 0.0284024 0.0470142
Trypanosoma brucei glycerol uptake protein, putative 0.00181745 0.0049447 0.0163083
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Echinococcus multilocularis cyclin dependent kinase 1 0.00439274 0.0284024 0.0462562
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00865019 0.0671823 0.121219
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.00292631 0.015045 0.0496205
Toxoplasma gondii hypothetical protein 0.0475983 0.42195 1
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.00292631 0.015045 0.020436
Brugia malayi DNA repair protein RAD51 homolog 1 0.00218767 0.00831696 0.00564695
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.018906 0.1606 0.301798
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00851103 0.0659147 0.119469
Loa Loa (eye worm) animal heme peroxidase 0.00546514 0.0381705 0.0651384
Echinococcus multilocularis serotonin receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus granulosus neuropeptide Y receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus Peroxidase homolog 0.00546514 0.0381705 0.0338489
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Echinococcus granulosus membrane bound acyltransferase:hhat 0.00181745 0.0049447 0.00091181
Toxoplasma gondii target of rapamycin (TOR), putative 0.00229353 0.00928121 0.0115173
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.00935842 0.0736333 0.133689
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0030107 0.0158137 0.0226993
Trichomonas vaginalis PIKK family atypical protein kinase 0.00186815 0.00540653 0.00259794
Echinococcus granulosus xaa Pro dipeptidase 0.00292631 0.015045 0.020436
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.00411321 0.0258561 0.0420962
Brugia malayi serine/threonine kinase 12 0.00575387 0.0408004 0.0533665
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.00260141 0.0120856 0.0147153
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0345919 0.303478 0.577986
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.00411321 0.0258561 0.0404593
Onchocerca volvulus Neuropeptide F receptor homolog 0.00865019 0.0671823 0.062991
Schistosoma mansoni neuropeptide F-like receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni rab6-interacting 0.00204943 0.00705775 0.00499641
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0344009 0.301738 1
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.00181745 0.0049447 0.00112988
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.291014
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00865019 0.0671823 0.121219
Brugia malayi sulfakinin receptor protein 0.00865019 0.0671823 0.0921226
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0276399 0.240154 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0030107 0.0158137 0.0219218
Mycobacterium ulcerans transcriptional regulator NrdR 0.00676103 0.0499744 0.155167
Schistosoma mansoni hypothetical protein 0.00181745 0.0049447 0.00091181
Entamoeba histolytica DNA repair protein RAD51, putative 0.00218767 0.00831696 0.00652464
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Toxoplasma gondii RNA-directed DNA polymerase 0.0345615 0.303201 0.715558
Entamoeba histolytica protein kinase, putative 0.00575387 0.0408004 0.0693735
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.00851103 0.0659147 0.204421
Giardia lamblia Rab geranylgeranyltransferase 0.0585599 0.521795 1
Schistosoma mansoni protein farnesyltransferase subunit beta 0.00411321 0.0258561 0.0413342
Schistosoma mansoni peroxidasin 0.00546514 0.0381705 0.0651384
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0585599 0.521795 1
Echinococcus multilocularis neuropeptides capa receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) AUR protein kinase 0.00575387 0.0408004 0.0702221
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Trypanosoma cruzi hypothetical protein, conserved 0.0109616 0.088236 0.27926
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis cyclin dependent kinase 1 0.00439274 0.0284024 0.0462562
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.00575387 0.0408004 0.0693735
Brugia malayi Hhat protein 0.00181745 0.0049447 0.000692947
Trypanosoma cruzi hypothetical protein, conserved 0.00411321 0.0258561 0.0701122
Brugia malayi follicle stimulating hormone receptor 0.00865019 0.0671823 0.0921226
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0030107 0.0158137 0.0364416
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0368879 0.324392 0.618413
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.162583
Leishmania major protein kinase, putative 0.00575387 0.0408004 0.120218
Plasmodium vivax methionine aminopeptidase 1b, putative 0.018906 0.1606 0.301161
Echinococcus granulosus neuropeptide receptor A26 0.00865019 0.0671823 0.121219
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0368879 0.324392 0.618413
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Trypanosoma cruzi lanosterol synthase, putative 0.00411321 0.0258561 0.0701122
Brugia malayi G protein-coupled receptor F59B2.13 0.00865019 0.0671823 0.0921226
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0276399 0.240154 1
Brugia malayi Peroxidasin 0.00546514 0.0381705 0.0495031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0116319 0.0943417 0.173719
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni biogenic amine receptor 0.00865019 0.0671823 0.121219
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) hypothetical protein 0.00181745 0.0049447 0.00091181
Toxoplasma gondii transcriptional elongation factor FACT140 0.00292631 0.015045 0.0253236
Brugia malayi Serotonin receptor 0.00865019 0.0671823 0.0921226
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.00133595 0.000558899 0.00184333
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0420962
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Trichomonas vaginalis PIKK family atypical protein kinase 0.00172403 0.0040938 0.0000624165
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis cyclin dependent kinase 0.00439274 0.0284024 0.0462562
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.00439274 0.0284024 0.057319
Echinococcus multilocularis neuropeptide receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Trypanosoma cruzi hypothetical protein, conserved 0.00411321 0.0258561 0.0701122
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.00411321 0.0258561 0.0480262
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0420962
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.00439274 0.0284024 0.0786492
Toxoplasma gondii creatinase domain-containing protein 0.00292631 0.015045 0.0253236
Plasmodium falciparum geranylgeranyltransferase, putative 0.00411321 0.0258561 0.0404593
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.00218767 0.00831696 0.0113066
Onchocerca volvulus 0.00204943 0.00705775 0.00259637
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00439274 0.0284024 0.0462562
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.0202188 0.172558 0.324912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0030107 0.0158137 0.0226993
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.00181745 0.0049447 0.00091181
Brugia malayi cell division control protein 2 homolog 0.00439274 0.0284024 0.0351532
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0030107 0.0158137 0.0166599
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.00181745 0.0049447 0.00091181
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.00292631 0.015045 0.0106195
Schistosoma mansoni opsin-like receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis xaa Pro dipeptidase 0.00292631 0.015045 0.020436
Schistosoma mansoni hypothetical protein 0.00865019 0.0671823 0.121219
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00865019 0.0671823 0.0921226
Plasmodium vivax geranylgeranyltransferase, putative 0.00411321 0.0258561 0.0404593
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0344009 0.301738 0.712053
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0345615 0.303201 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.00851103 0.0659147 0.204421
Onchocerca volvulus Peroxidasin homolog 0.00546514 0.0381705 0.0338489
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00865019 0.0671823 0.121219
Entamoeba histolytica aminopeptidase, putative 0.00292631 0.015045 0.019542
Onchocerca volvulus 0.00546514 0.0381705 0.0338489
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.27926
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.018906 0.1606 0.521883
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0109616 0.088236 0.161916
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.018906 0.1606 0.646597
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0585599 0.521795 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi Dopamine receptor protein 2 0.00865019 0.0671823 0.0921226
Echinococcus granulosus somatostatin receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis dro:myosuppressin receptor 0.00865019 0.0671823 0.121219
Trypanosoma cruzi cdc2-related kinase 1 0.00439274 0.0284024 0.0786492
Loa Loa (eye worm) neuropeptide F receptor 0.00865019 0.0671823 0.121219
Brugia malayi metallopeptidase family M24 containing protein 0.00292631 0.015045 0.0155307
Echinococcus granulosus methionyl aminopeptidase 2 0.00851103 0.0659147 0.118769
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.00292631 0.015045 0.0496205
Loa Loa (eye worm) DNA-binding protein 0.00292631 0.015045 0.020436
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00851103 0.0659147 0.119469
Trichomonas vaginalis transmembrane protein nessy, putative 0.00181745 0.0049447 0.00170592
Trichomonas vaginalis PIKK family atypical protein kinase 0.00178184 0.00462038 0.00107951
Brugia malayi Telomerase reverse transcriptase 0.076498 0.685189 1
Schistosoma mansoni peptidase 0.00292631 0.015045 0.020436
Schistosoma mansoni growth hormone secretagogue receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0344009 0.301738 0.574623
Trypanosoma brucei methionine aminopeptidase 2, putative 0.00851103 0.0659147 0.217396
Onchocerca volvulus 0.00546514 0.0381705 0.0338489
Treponema pallidum methionine aminopeptidase (map) 0.018906 0.1606 0.524456
Trypanosoma cruzi Metallopeptidase family M24, putative 0.00292631 0.015045 0.0338645
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni neuropeptide F-like receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) rad51 0.00218767 0.00831696 0.0074305
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Brugia malayi Guanylate kinase family protein 0.00293558 0.0151294 0.0156548
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115927 0.0939847 0.173029
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.00411321 0.0258561 0.0420962
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0109616 0.088236 0.27926
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0344009 0.301738 0.574623
Toxoplasma gondii meiotic recombination protein DMC1 family protein 0.00218767 0.00831696 0.00920762
Plasmodium falciparum protein kinase 5 0.00439274 0.0284024 0.0453857
Trypanosoma cruzi aurora B kinase, putative 0.00575387 0.0408004 0.120218
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0585599 0.521795 1
Brugia malayi hypothetical protein 0.00204943 0.00705775 0.00379711
Onchocerca volvulus Dual oxidase homolog 0.00546514 0.0381705 0.0338489
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0109616 0.088236 0.161916
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0368879 0.324392 0.618413
Loa Loa (eye worm) MBOAT family protein 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis orexin receptor type 2 0.00865019 0.0671823 0.121219
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.00292631 0.015045 0.019542
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi latrophilin 2 splice variant baaae 0.0202188 0.172558 0.246923
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.00181745 0.0049447 0.00091181
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0344009 0.301738 0.995094
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.018906 0.1606 0.301798
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Trypanosoma cruzi cdc2-related kinase 3 0.00439274 0.0284024 0.0786492
Echinococcus granulosus neuropeptides capa receptor 0.00865019 0.0671823 0.121219
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0109616 0.088236 0.161152
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Brugia malayi neuropeptide F receptor 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.00935842 0.0736333 0.133689
Schistosoma mansoni neuropeptide receptor 0.00865019 0.0671823 0.121219
Giardia lamblia Rab geranylgeranyltransferase 0.0109616 0.088236 0.161916
Giardia lamblia Telomerase catalytic subunit 0.0345615 0.303201 0.577451
Brugia malayi G-protein coupled receptor 0.00865019 0.0671823 0.0921226
Trypanosoma brucei lanosterol synthase 0.00411321 0.0258561 0.0852771
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.27926
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Echinococcus granulosus neuropeptides capa receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) neuropeptide F receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus o acyltransferase membrane bound domain 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0344009 0.301738 0.574623
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0701122
Plasmodium vivax methionine aminopeptidase 1a, putative 0.018906 0.1606 0.301161
Schistosoma mansoni histamine h1 receptor 0.00865019 0.0671823 0.121219
Brugia malayi serine/threonine-protein kinase 6 0.00575387 0.0408004 0.0533665
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0585599 0.521795 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0475983 0.42195 0.807148
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.018906 0.1606 0.301798
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.00292631 0.015045 0.020436
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.018906 0.1606 0.301161
Brugia malayi neuropeptide F receptor 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis RUN 0.00204943 0.00705775 0.00499641
Echinococcus multilocularis g protein coupled receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus granulosus fmrfamide receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0109616 0.088236 0.161152
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis neuropeptide FF receptor 2 0.00865019 0.0671823 0.121219
Onchocerca volvulus Chorion peroxidase homolog 0.00546514 0.0381705 0.0338489
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0368879 0.324392 0.618716
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0420962
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0344009 0.301738 0.574234
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.00292631 0.015045 0.0155307
Loa Loa (eye worm) hypothetical protein 0.00411321 0.0258561 0.0413342
Giardia lamblia Rab geranylgeranyltransferase 0.00411321 0.0258561 0.0413342
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.11106 1 1
Echinococcus multilocularis Polycystic kidney disease protein 0.00204943 0.00705775 0.00499641
Schistosoma mansoni biogenic amine receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus G protein coupled receptor 139 0.00865019 0.0671823 0.121219
Toxoplasma gondii methionine aminopeptidase 2, putative 0.00851103 0.0659147 0.147174
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Loa Loa (eye worm) hhat protein 0.00181745 0.0049447 0.00091181
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.018906 0.1606 0.52968
Brugia malayi hypothetical protein 0.00546514 0.0381705 0.0495031
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.00181745 0.0049447 0.00091181
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.00292631 0.015045 0.0338645
Echinococcus multilocularis ATPase, H+ transporting, lysosomal accessory 0.03498 0.307013 0.584818
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.00292631 0.015045 0.020436
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00444775 0.0289034 0.0472248
Echinococcus multilocularis somatostatin receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.00181745 0.0049447 0.00091181
Trichomonas vaginalis porcupine, putative 0.00181745 0.0049447 0.00170592
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0585599 0.521795 1
Echinococcus granulosus dna repair protein rad51 1 0.00218767 0.00831696 0.0074305
Entamoeba histolytica cell division protein kinase 2, putative 0.00439274 0.0284024 0.0453857
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Leishmania major RAD51/dmc1 protein 0.00218767 0.00831696 0.0113066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Loa Loa (eye worm) hypothetical protein 0.0106283 0.0852003 0.156048
Plasmodium vivax methionine aminopeptidase 1c, putative 0.00292631 0.015045 0.019542
Brugia malayi serine/threonine protein kinase 6 0.00575387 0.0408004 0.0533665
Plasmodium vivax farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0404593
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.4 nM Antimalarial activity against Plasmodium falciparum. ChEMBL. 11741486
EC50 (functional) = 2.4 nM Antimalarial activity against Plasmodium falciparum. ChEMBL. 11741486
IC50 (functional) = 1.2 uM Cytotoxicity against BC cells. ChEMBL. 11741486
IC50 (functional) = 1.7 uM Cytotoxicity against KB cells. ChEMBL. 11741486
IC50 (functional) = 6.6 uM Cytotoxicity against vero cells. ChEMBL. 11741486
TI (ADMET) = 2.8 Therapeutic index (TI) determined as IC50 of vero cells to that of EC50 ChEMBL. 11741486

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 11741486

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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