Detailed information for compound 255120

Basic information

Technical information
  • TDR Targets ID: 255120
  • Name: 3-benzhydrylpyridine
  • MW: 245.318 | Formula: C18H15N
  • H donors: 0 H acceptors: 1 LogP: 4.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)C(c1cccnc1)c1ccccc1
  • InChi: 1S/C18H15N/c1-3-8-15(9-4-1)18(16-10-5-2-6-11-16)17-12-7-13-19-14-17/h1-14,18H
  • InChiKey: HGVLJGHVYCBNBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[di(phenyl)methyl]pyridine
  • 3678-71-5
  • NSC60654
  • EINECS 222-954-9
  • NCI60_004676
  • AO-801/41077384
  • ZINC04100364
  • ST5443821
  • Pyridine, 3-(diphenylmethyl)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0398 0.0394
Schistosoma mansoni transcription factor LCR-F1 0.0023 0.0074 0.0071
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0146 0.1323
Onchocerca volvulus 0.005 0.0398 0.0455
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Echinococcus granulosus dna polymerase eta 0.002 0.0037 0.0038
Echinococcus multilocularis regulator of G protein signaling 7 0.003 0.0156 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0023 0.0075 0.0075
Leishmania major heat shock protein, putative 0.0028 0.013 0.1038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0025 0.0021
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0021
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0099 0.1006 0.1006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0023 0.0074 0.0081
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0025 0.0025
Schistosoma mansoni endoplasmin 0.0068 0.0617 0.0613
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0023 0.0075 0.0244
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0075 0.0421
Schistosoma mansoni ap endonuclease 0.004 0.0281 0.0277
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0021
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0037 0.0117
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.3357 0.3354
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0281 0.0281
Plasmodium vivax heat shock protein, putative 0.0028 0.013 0.1026
Mycobacterium tuberculosis Probable hydrolase 0.0023 0.0075 0.0244
Loa Loa (eye worm) hypothetical protein 0.006 0.0527 0.0527
Echinococcus granulosus peroxidasin 0.0727 0.8666 1
Onchocerca volvulus 0.0727 0.8666 1
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0398 0.0455
Giardia lamblia Heat shock protein HSP 90-alpha 0.0068 0.0617 0.643
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0398 0.0455
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0075 0.0421
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Treponema pallidum heat shock protein 90 0.0054 0.0449 0.0546
Toxoplasma gondii heat shock protein 75, putative 0.0028 0.013 0.1026
Echinococcus multilocularis serotonin transporter 0.0292 0.3357 0.3871
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.005 0.0398 0.0398
Mycobacterium tuberculosis Probable lipase LipE 0.0023 0.0075 0.0244
Echinococcus granulosus heat shock protein 90 0.0054 0.0449 0.0514
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0939 1
Brugia malayi Fli-1 protein 0.0219 0.2472 0.2469
Loa Loa (eye worm) hypothetical protein 0.004 0.0286 0.0286
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0025 0.0025
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0436 0.6668
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0037 0.0033
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0565 0.0561
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Schistosoma mansoni endoplasmin 0.0068 0.0617 0.0613
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0037 0.0033
Trypanosoma cruzi heat shock protein, putative 0.0028 0.013 0.1038
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1526 0.1758
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0281 0.1569
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0037 0.0011
Schistosoma mansoni hypothetical protein 0.0348 0.4044 0.4042
Brugia malayi Animal haem peroxidase family protein 0.0727 0.8666 0.8665
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0337 0.0384
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0939 0.0916
Brugia malayi RNA binding protein 0.0063 0.0565 0.0561
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0025 0.0025
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0436 0.4428
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0401 0.0398
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0025 0.0025
Echinococcus granulosus serotonin transporter 0.0292 0.3357 0.3871
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0146 0.0146
Onchocerca volvulus Alhambra homolog 0.0029 0.0146 0.0165
Echinococcus multilocularis protein patched 0.0043 0.0313 0.0357
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0398 0.0455
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0436 0.4428
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0449 0.0425
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0025 0.0025
Schistosoma mansoni gabp alpha 0.0072 0.0675 0.0671
Loa Loa (eye worm) hypothetical protein 0.005 0.0398 0.0398
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0023 0.0074 0.0081
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.052 0.6145 0.709
Loa Loa (eye worm) hypothetical protein 0.005 0.0398 0.0398
Echinococcus multilocularis heat shock protein 90 0.0054 0.0449 0.0514
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0313 0.0357
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.0449 0.457
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Echinococcus multilocularis GPCR, family 2 0.0019 0.0025 0.0025
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0398 0.5958
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0025 0.0025
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0054 0.0449 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0337 0.0333
Plasmodium vivax hypothetical protein, conserved 0.005 0.0398 0.5958
Mycobacterium tuberculosis Conserved protein 0.0023 0.0075 0.0244
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0398 0.0455
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0398 0.0398
Toxoplasma gondii hypothetical protein 0.005 0.0398 0.5958
Loa Loa (eye worm) hypothetical protein 0.0053 0.0436 0.0436
Trichomonas vaginalis glutaminase, putative 0.0836 1 1
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0337 0.0333
Mycobacterium tuberculosis Probable lipase LipD 0.0023 0.0075 0.0244
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0037 0.0038
Schistosoma mansoni heat shock protein 0.0068 0.0617 0.0613
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0221 0.025
Plasmodium falciparum transporter, putative 0.005 0.0398 0.5496
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Schistosoma mansoni ap endonuclease 0.004 0.0281 0.0277
Onchocerca volvulus 0.0023 0.0075 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.036 0.0336
Giardia lamblia PHD finger protein 15 0.0029 0.0146 0.1216
Trypanosoma brucei heat shock protein, putative 0.0068 0.0617 0.643
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0281 0.31
Onchocerca volvulus 0.0727 0.8666 1
Schistosoma mansoni hypothetical protein 0.0348 0.4044 0.4042
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0221 0.0217
Trypanosoma brucei heat shock protein, putative 0.0068 0.0617 0.643
Trypanosoma brucei Heat shock protein 83, putative 0.0068 0.0617 0.643
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0674 0.065
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1339 0.1339
Schistosoma mansoni hypothetical protein 0.0023 0.0074 0.0071
Echinococcus granulosus expressed protein 0.0371 0.4322 0.4985
Loa Loa (eye worm) hypothetical protein 0.0052 0.043 0.043
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0075 0.005
Loa Loa (eye worm) hypothetical protein 0.005 0.0398 0.0398
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0021
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Loa Loa (eye worm) blistered cuticle protein 3 0.0727 0.8666 0.8666
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0939 0.0916
Brugia malayi Animal haem peroxidase family protein 0.0727 0.8666 0.8665
Brugia malayi Blistered cuticle protein 3 0.0727 0.8666 0.8665
Echinococcus granulosus chromobox protein 1 0.0072 0.0674 0.0773
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0025 0.0021
Schistosoma mansoni DNA polymerase eta 0.002 0.0037 0.0033
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0939 1
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0324 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0313 0.0289
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0398 0.0394
Brugia malayi regulator of G-protein signaling egl-10 0.003 0.0156 0.0152
Brugia malayi Ets-domain containing protein 0.0072 0.0675 0.0671
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0951 0.1094
Onchocerca volvulus 0.005 0.0398 0.0455
Loa Loa (eye worm) hypothetical protein 0.0062 0.0547 0.0547
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0449 0.0425
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Toxoplasma gondii heat shock protein 90, putative 0.0068 0.0617 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0939 1
Brugia malayi hypothetical protein 0.0019 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0081 0.0089
Brugia malayi PXA domain containing protein 0.0019 0.0025 0.0021
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0398 0.5
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0023 0.0075 0.0244
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0029 0.0029
Mycobacterium ulcerans lipase LipD 0.0023 0.0075 0.0038
Echinococcus granulosus regulator of G protein signaling 7 0.003 0.0156 0.0176
Schistosoma mansoni hypothetical protein 0.0041 0.0294 0.0291
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0674 0.0674
Brugia malayi Animal haem peroxidase family protein 0.0727 0.8666 0.8665
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0021
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0021
Brugia malayi jmjC domain containing protein 0.0035 0.0221 0.0217
Loa Loa (eye worm) animal heme peroxidase 0.0727 0.8666 0.8666
Loa Loa (eye worm) animal heme peroxidase 0.0727 0.8666 0.8666
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0025 0.0025
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Schistosoma mansoni hypothetical protein 0.0041 0.0294 0.0291
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0146 0.1323
Loa Loa (eye worm) hypothetical protein 0.0041 0.0295 0.0295
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0939 0.1079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Mycobacterium ulcerans esterase/lipase LipP 0.0023 0.0075 0.0038
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0021
Echinococcus granulosus dna polymerase kappa 0.002 0.0037 0.0038
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0398 0.0394
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0156
Mycobacterium tuberculosis Probable esterase LipL 0.0023 0.0075 0.0244
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0021
Echinococcus multilocularis regulator of G protein signaling 7 0.003 0.0156 0.0176
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0025
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0281 0.3809
Brugia malayi Heterochromatin protein 1 0.0072 0.0674 0.067
Trypanosoma brucei heat shock protein 90, putative 0.0068 0.0617 0.643
Trypanosoma brucei heat shock protein 84, putative 0.0028 0.013 0.1038
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.0025
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0025 0.0021
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Trypanosoma cruzi Heat shock protein 83, putative 0.0068 0.0617 0.643
Brugia malayi Endoplasmin precursor 0.0068 0.0617 0.0613
Loa Loa (eye worm) glutaminase 0.0836 1 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0021
Echinococcus multilocularis peroxidasin 0.0727 0.8666 1
Echinococcus granulosus chromobox protein 1 0.0072 0.0674 0.0773
Loa Loa (eye worm) hypothetical protein 0.0292 0.3357 0.3357
Brugia malayi hypothetical protein 0.0019 0.0025 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0939 0.0916
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1526 0.1758
Echinococcus multilocularis endoplasmin 0.0054 0.0449 0.0514
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2454 0.2828
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0939 0.1079
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0281 0.271
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0939 0.0935
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0523 0.0523
Onchocerca volvulus Chorion peroxidase homolog 0.0727 0.8666 1
Plasmodium vivax heat shock protein 86, putative 0.0068 0.0617 1
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Loa Loa (eye worm) hypothetical protein 0.0032 0.018 0.018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0398 0.0394
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0075 0.005
Plasmodium falciparum amino acid transporter, putative 0.005 0.0398 0.5496
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Onchocerca volvulus 0.0023 0.0075 0.0082
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0075 0.0071
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0398 0.0394
Echinococcus multilocularis geminin 0.0348 0.4044 0.4664
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0436 0.4428
Brugia malayi Peroxidasin 0.0727 0.8666 0.8665
Giardia lamblia Heat shock protein HSP 90-alpha 0.0054 0.0449 0.457
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0075 0.005
Schistosoma mansoni peroxidasin 0.0727 0.8666 0.8665
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0023 0.0075 0.0244
Echinococcus multilocularis heat shock protein 90 0.0068 0.0617 0.0708
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0029 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0029 0.0025
Mycobacterium ulcerans heat shock protein 90 0.0054 0.0449 0.0414
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0028 0.013 0.0146
Schistosoma mansoni heat shock protein 0.0028 0.013 0.0126
Trypanosoma brucei heat shock protein, putative 0.0068 0.0617 0.643
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0398 0.0394
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0313 0.0357
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0398 0.0455
Brugia malayi CHE-14 protein 0.0043 0.0313 0.0309
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0436 0.6287
Onchocerca volvulus Peroxidasin homolog 0.0727 0.8666 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0037 0.0038
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0398 0.0455
Brugia malayi chromobox protein homolog 3 0.004 0.0286 0.0283
Echinococcus multilocularis chromobox protein 1 0.0072 0.0674 0.0773
Schistosoma mansoni hypothetical protein 0.0041 0.0294 0.0291
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0295 0.0291
Loa Loa (eye worm) intermediate filament protein 0.0017 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0939 0.0916
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.036 0.0336
Schistosoma mansoni chromobox protein 0.0072 0.0674 0.067
Onchocerca volvulus 0.0292 0.3357 0.3871
Onchocerca volvulus 0.005 0.0398 0.0455
Trichomonas vaginalis endoplasmin, putative 0.0041 0.0298 0.0274
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0675 0.0675
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0017 0.0004 0.0004
Toxoplasma gondii exonuclease III APE 0.004 0.0281 0.3809
Schistosoma mansoni heat shock protein 0.0068 0.0617 0.0613
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0023 0.0075 0.0038
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0398 0.0394
Onchocerca volvulus Dual oxidase homolog 0.0727 0.8666 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0025 0.0025
Brugia malayi Animal haem peroxidase family protein 0.0727 0.8666 0.8665
Entamoeba histolytica hypothetical protein 0.0023 0.0074 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0286 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0939 0.0935
Loa Loa (eye worm) animal heme peroxidase 0.0727 0.8666 0.8666
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0398 0.0455
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.003 0.0156 0.0156
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0029 0.0029
Echinococcus granulosus expressed conserved protein 0.0093 0.0932 0.1072
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0029 0.0029
Trichomonas vaginalis heat shock protein, putative 0.0068 0.0617 0.0593
Trypanosoma brucei heat shock protein, putative 0.0068 0.0617 0.643
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0313 0.0313
Schistosoma mansoni kinase 0.0048 0.0375 0.0371
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Trichomonas vaginalis esterase, putative 0.0023 0.0075 0.005
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1006 0.1157
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0674 0.065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0075 0.0421
Brugia malayi jmjC domain containing protein 0.0095 0.0951 0.0948
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0281 0.032
Echinococcus granulosus jumonji domain containing protein 0.004 0.0285 0.0324
Trypanosoma brucei heat shock protein, putative 0.0068 0.0617 0.643
Plasmodium vivax endoplasmin, putative 0.0068 0.0617 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0398 0.5958
Schistosoma mansoni chromobox protein 0.0072 0.0674 0.067
Onchocerca volvulus Peroxidasin homolog 0.0727 0.8666 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0286 0.0326
Loa Loa (eye worm) hypothetical protein 0.0029 0.0146 0.0146
Onchocerca volvulus 0.0727 0.8666 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0221 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0565 0.0561
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0146 0.0165
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0054 0.0449 0.2646
Brugia malayi Hsp90 protein 0.0028 0.013 0.0126
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0054 0.0449 1
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0449 0.0425
Trypanosoma brucei polo-like protein kinase 0.0094 0.0939 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0054 0.0449 0.457
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0565 0.0561
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0436 0.6668
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0037 0.0033
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0398 0.0455
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0398 0.0455
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0281 0.0245
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0313
Trypanosoma brucei heat shock protein, putative 0.0068 0.0617 0.643
Echinococcus granulosus heat shock protein 90 0.0068 0.0617 0.0708
Loa Loa (eye worm) hypothetical protein 0.0218 0.2454 0.2454
Echinococcus granulosus hypothetical protein 0.051 0.6017 0.6942
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0037 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0281 0.0257
Echinococcus granulosus GPCR family 2 0.0019 0.0025 0.0025
Toxoplasma gondii hypothetical protein 0.005 0.0398 0.5958
Loa Loa (eye worm) RNA binding protein 0.0063 0.0565 0.0565
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0398 0.0394
Echinococcus multilocularis dna polymerase eta 0.002 0.0037 0.0038
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0146 0.0143
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0025 0.0021
Onchocerca volvulus Peroxidase homolog 0.0727 0.8666 1
Mycobacterium tuberculosis Conserved protein 0.0023 0.0075 0.0244
Brugia malayi Animal haem peroxidase family protein 0.0727 0.8666 0.8665
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0021
Onchocerca volvulus 0.0023 0.0075 0.0082
Leishmania major hypothetical protein, conserved 0.0023 0.0075 0.0421
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0436 0.6287
Brugia malayi beta-lactamase family protein 0.0023 0.0075 0.0071
Brugia malayi hypothetical protein 0.0053 0.0436 0.0432
Loa Loa (eye worm) hypothetical protein 0.005 0.0399 0.0399
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0565 0.0561
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0025 0.0025
Brugia malayi PHD-finger family protein 0.0029 0.0146 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0939 0.0916
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0565 0.0561
Brugia malayi TAR-binding protein 0.0063 0.0565 0.0561
Loa Loa (eye worm) serotonin transporter b 0.0292 0.3357 0.3357
Brugia malayi MH2 domain containing protein 0.0127 0.1339 0.1336
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0025
Echinococcus granulosus endoplasmin 0.0054 0.0449 0.0514
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0398 0.0394
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0281 0.032
Trypanosoma cruzi heat shock protein 90, putative 0.0068 0.0617 0.643
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0281 0.261
Echinococcus multilocularis peregrin 0.0029 0.0146 0.0165
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0148 0.1595 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0023 0.0075 0.0082
Trichomonas vaginalis heat shock protein, putative 0.0028 0.013 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0142 0.0117
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.3357 0.3354
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0939 0.1079
Entamoeba histolytica heat shock protein 90, putative 0.0068 0.0617 0.6033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0565 0.0565
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0337 0.0384
Echinococcus multilocularis beta LACTamase domain containing family member 0.0023 0.0075 0.0082
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0286 0.0262
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0617 0.643
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Brugia malayi hypothetical protein 0.0727 0.8666 0.8665
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0565 0.0647
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1339 0.1339
Brugia malayi Bromodomain containing protein 0.0029 0.0146 0.0143
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0028 0.013 0.0146
Echinococcus granulosus heat shock protein 0.0068 0.0617 0.0708
Brugia malayi beta-lactamase 0.0023 0.0075 0.0071
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0281 0.271
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1006 0.1002
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0281 0.0257
Schistosoma mansoni glutaminase 0.0836 1 1
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0675 0.0775
Onchocerca volvulus 0.0032 0.018 0.0203
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0939 0.0916
Echinococcus granulosus regulator of G protein signaling 7 0.003 0.0156 0.0176
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0221 0.025
Trypanosoma brucei heat shock protein, putative 0.0068 0.0617 0.643
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0337 0.0384
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0279 0.2687
Schistosoma mansoni z-protein (S1r protein) 0.003 0.0156 0.0152
Echinococcus multilocularis protein dispatched 1 0.0049 0.0387 0.0442
Echinococcus multilocularis chromobox protein 1 0.0072 0.0674 0.0773
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0398 0.0398
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0617 0.643
Onchocerca volvulus Peroxidase homolog 0.0727 0.8666 1
Echinococcus granulosus peregrin 0.0029 0.0146 0.0165
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Brugia malayi hypothetical protein 0.0023 0.0074 0.0071
Brugia malayi Ets-domain containing protein 0.0072 0.0675 0.0671
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0398 0.0394
Plasmodium falciparum phd finger protein, putative 0.0029 0.0146 0.0331
Echinococcus multilocularis dna polymerase kappa 0.002 0.0037 0.0038
Loa Loa (eye worm) beta-lactamase 0.0023 0.0075 0.0075
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0617 0.643
Schistosoma mansoni ets-related 0.0219 0.2472 0.2469
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1024 0.1021
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0324 0.03
Loa Loa (eye worm) hypothetical protein 0.005 0.0398 0.0398
Brugia malayi N-terminal motif family protein 0.0218 0.2454 0.2451
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0449 0.457
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0146 0.1323
Entamoeba histolytica hypothetical protein 0.0023 0.0074 0.0502
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0025
Loa Loa (eye worm) fli-1 protein 0.0219 0.2472 0.2472
Plasmodium falciparum heat shock protein 90 0.0068 0.0617 1
Mycobacterium tuberculosis Conserved protein 0.0023 0.0075 0.0244
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0221 0.0217
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0527 0.0524
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0398 0.0455
Brugia malayi beta-lactamase family protein 0.0023 0.0075 0.0071
Loa Loa (eye worm) heat shock protein 90 0.0068 0.0617 0.0617
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0939 0.0939
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Schistosoma mansoni hypothetical protein 0.0024 0.0081 0.0077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0527 0.0524
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0146 0.0165
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0021
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0029 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0075 0.0071
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.3357 0.3357
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0028 0.013 0.1072
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0675 0.0775
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0023 0.0075 0.0071
Echinococcus granulosus geminin 0.0348 0.4044 0.4664
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0939 0.0916
Loa Loa (eye worm) hypothetical protein 0.0292 0.3357 0.3357
Entamoeba histolytica hypothetical protein 0.0023 0.0074 0.0502
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0337 0.0333
Toxoplasma gondii Hsp90 domain-containing protein 0.0028 0.013 0.1026
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0025 0.0025
Toxoplasma gondii heat shock protein HSP90 0.0068 0.0617 1
Schistosoma mansoni hypothetical protein 0.0029 0.0146 0.0143
Entamoeba histolytica heat shock protein 90, putative 0.0068 0.0617 0.6033
Leishmania major heat shock protein 83-1 0.0068 0.0617 0.643
Mycobacterium ulcerans hypothetical protein 0.0023 0.0075 0.0038
Mycobacterium ulcerans glutaminase 0.0836 1 1
Giardia lamblia Grp94/Hsp90 0.0054 0.0449 0.457
Brugia malayi heat shock protein 90 0.0068 0.0617 0.0613
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0075 0.005
Loa Loa (eye worm) endoplasmin 0.0068 0.0617 0.0617
Brugia malayi hypothetical protein 0.0034 0.0208 0.0204
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.3357 0.3354
Giardia lamblia Kinase, PLK 0.0094 0.0939 1
Schistosoma mansoni regulator of G protein signaling 0.003 0.0156 0.0152
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0527 0.0527
Brugia malayi PXA domain containing protein 0.0019 0.0025 0.0021
Mycobacterium ulcerans beta-lactamase 0.0023 0.0075 0.0038
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0398 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0029 0.0025
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0025
Schistosoma mansoni peroxidasin 0.0727 0.8666 0.8665
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0398 0.0394
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0951 0.1094
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0398 0.0455
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0028 0.013 0.0146
Schistosoma mansoni hypothetical protein 0.0041 0.0295 0.0291
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1006 1
Echinococcus multilocularis expressed protein 0.0371 0.4322 0.4985
Plasmodium vivax heat shock protein 90, putative 0.0028 0.013 0.1026
Leishmania major hypothetical protein, conserved 0.0053 0.0436 0.4428
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0281 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Plasmodium falciparum endoplasmin, putative 0.0041 0.0298 0.345
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0313 0.0357
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0281 0.271
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0081 0.0089
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0281 0.271
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0142 0.0117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0324 0.037
Schistosoma mansoni hypothetical protein 0.0041 0.0294 0.0291
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0075 0.005
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0037 0.0011
Trypanosoma brucei heat shock protein 90, putative 0.0068 0.0617 0.643
Brugia malayi hypothetical protein 0.005 0.0398 0.0394
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.3357 0.3357
Loa Loa (eye worm) glutaminase 2 0.0836 1 1
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0713 0.071
Echinococcus multilocularis conserved hypothetical protein 0.0505 0.5954 0.6869
Brugia malayi Serotonin receptor 0.0342 0.3964 0.3961
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0285 0.0324
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0939 0.9318
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0565 0.0565
Loa Loa (eye worm) heat shock protein 75 0.0028 0.013 0.013
Echinococcus granulosus tar DNA binding protein 0.0063 0.0565 0.0647
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0054 0.0449 0.0514
Schistosoma mansoni patched 1 0.0043 0.0313 0.0309
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0398 0.0398
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.3357 1
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1006 0.1157
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0298 0.0274
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0029 0.0025
Echinococcus multilocularis heat shock protein 0.0068 0.0617 0.0708
Loa Loa (eye worm) hypothetical protein 0.0727 0.8666 0.8666
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0025 0.0021
Schistosoma mansoni hypothetical protein 0.0019 0.0025 0.0021
Trypanosoma brucei heat shock protein, putative 0.0068 0.0617 0.643
Loa Loa (eye worm) hypothetical protein 0.005 0.0398 0.0398
Entamoeba histolytica hypothetical protein 0.0023 0.0074 0.0502
Echinococcus multilocularis expressed conserved protein 0.0093 0.0932 0.1072
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0565 0.0561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0337 0.0384
Loa Loa (eye worm) hypothetical protein 0.0292 0.3357 0.3357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0337 0.0333
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0398 0.0394
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0281 0.271
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0025 0.0021
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0398 0.5958
Loa Loa (eye worm) animal heme peroxidase 0.0727 0.8666 0.8666
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0398 0.0394
Plasmodium vivax amine transporter, putative 0.005 0.0398 0.5958

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 45.552 uM PUBCHEM_BIOASSAY: Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504435] ChEMBL. No reference
GI50 (functional) -4.182 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.077 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.009 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Ki (binding) = 0.78 uM Affinity of the compound to displace binding of [3H]WIN35,428 to dopamine transporter ChEMBL. 12565962
Ki (binding) = 0.78 uM Affinity of the compound to displace binding of [3H]WIN35,428 to dopamine transporter ChEMBL. 12565962
Ki (binding) = 0.86 uM Inhibition of [3H]-DA uptake evaluated at the dopamine transporter ChEMBL. 12565962
Ki (binding) = 0.86 uM Inhibition of [3H]-DA uptake evaluated at the dopamine transporter ChEMBL. 12565962
Ki (binding) = 7.32 uM Inhibition of [3H]-NE uptake evaluated at the monoamine transporter (NET) ChEMBL. 12565962
Ki (binding) = 7.32 uM Inhibition of [3H]-NE uptake evaluated at the monoamine transporter (NET) ChEMBL. 12565962
Ki (binding) = 12.6 uM Inhibition of [3H]-5-HT uptake evaluated at the Serotonin transporter ChEMBL. 12565962
Ki (binding) = 12.6 uM Inhibition of [3H]-5-HT uptake evaluated at the Serotonin transporter ChEMBL. 12565962
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.