Detailed information for compound 255937

Basic information

Technical information
  • TDR Targets ID: 255937
  • Name: 2,4-dimethyl-6-phenyl-1-(1H-pyrazol-5-yl)pyri din-1-ium perchlorate
  • MW: 349.769 | Formula: C16H16ClN3O4
  • H donors: 1 H acceptors: 5 LogP: 5.86 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][Cl](=O)(=O)=O.Cc1cc(C)[n+](c(c1)c1ccccc1)c1cc[nH]n1
  • InChi: 1S/C16H16N3.ClHO4/c1-12-10-13(2)19(16-8-9-17-18-16)15(11-12)14-6-4-3-5-7-14;2-1(3,4)5/h3-11H,1-2H3,(H,17,18);(H,2,3,4,5)/q+1;/p-1
  • InChiKey: GIQLNPZYIHRIDZ-UHFFFAOYSA-M  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.025 0.0234
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0143 0.0143
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0036 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Brugia malayi Bromodomain containing protein 0.0075 0.0676 0.0661
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0095 0.0894 0.0894
Plasmodium falciparum peptidase, putative 0.0095 0.0894 0.257
Brugia malayi Kringle domain containing protein 0.0018 0.0031 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0083 0.0196
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.002 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0894 0.0894
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0234 0.0218
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0052 0.0052
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0904 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0036 0.0036
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0052 0.0036
Schistosoma mansoni hypothetical protein 0.0022 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0043 0.031 0.0294
Echinococcus granulosus inositol monophosphatase 1 0.011 0.1065 0.105
Echinococcus multilocularis prolyl endopeptidase 0.0904 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1349 0.1335
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0473 0.0457
Echinococcus granulosus calpain A 0.0056 0.0452 0.0436
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.025 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0386 0.1083
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0052 0.0052
Echinococcus multilocularis geminin 0.0345 0.371 0.3699
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.006 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0036 0.0036
Brugia malayi Bromodomain containing protein 0.0039 0.0261 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1349 0.1349
Echinococcus granulosus snurportin 1 0.03 0.3206 0.3195
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0359 0.3872 0.3872
Brugia malayi RNA, U transporter 1 0.008 0.0727 0.0712
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0095 0.0894 0.0894
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0386 0.0386
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.002 0.0004
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0095 0.0894 0.0879
Plasmodium vivax aspartyl proteinase, putative 0.005 0.0384 0.1077
Entamoeba histolytica myo-inositol monophosphatase, putative 0.011 0.1065 0.3071
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.032 0.343 0.3419
Schistosoma mansoni survival motor neuron protein 0.005 0.0391 0.0391
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.032 0.343 0.3419
Onchocerca volvulus 0.0033 0.0199 0.0183
Plasmodium vivax RNA helicase-1, putative 0.032 0.343 1
Schistosoma mansoni cathepsin D (A01 family) 0.0146 0.147 0.147
Loa Loa (eye worm) inositol-1 0.011 0.1065 0.105
Plasmodium falciparum eukaryotic initiation factor 4A 0.032 0.343 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.005 0.0384 0.0368
Echinococcus granulosus importin subunit beta 1 0.0028 0.0143 0.0127
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.2262 0.2249
Onchocerca volvulus 0.0098 0.0929 0.0914
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.1349 0.1335
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0894 0.257
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0031 0.0014
Echinococcus granulosus acylamino acid releasing enzyme 0.0095 0.0894 0.0879
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0082 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0369 0.0369
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0052 0.0052
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0052 0.0052
Schistosoma mansoni inositol monophosphatase 0.011 0.1065 0.1065
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.025 0.0234
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.025 0.0684
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1349 0.1349
Trypanosoma brucei antigen, putative 0.002 0.0052 0.0052
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.006
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.025 0.0234
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.1733 0.1719
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0369 0.0369
Loa Loa (eye worm) calpain 0.002 0.0052 0.0036
Onchocerca volvulus 0.0031 0.0176 0.016
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.032 0.343 0.343
Loa Loa (eye worm) hypothetical protein 0.0053 0.0425 0.0409
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.0068
Plasmodium vivax importin-beta 2, putative 0.0028 0.0143 0.0372
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0016
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0425 0.0409
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0369 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0894 0.257
Loa Loa (eye worm) hypothetical protein 0.0095 0.0894 0.0879
Leishmania major importin beta-1 subunit, putative 0.0023 0.0083 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0386 0.1083
Plasmodium vivax SET domain protein, putative 0.0031 0.0176 0.0468
Leishmania major hypothetical protein, conserved 0.0018 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0041
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.032 0.343 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0095 0.0894 0.2526
Echinococcus multilocularis acylamino acid releasing enzyme 0.0095 0.0894 0.0879
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.1733 0.1719
Echinococcus multilocularis snurportin 1 0.03 0.3206 0.3195
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0359 0.3872 0.3872
Treponema pallidum ATP-dependent RNA helicase 0.032 0.343 1
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0057 0.012
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.1065 0.1065
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0503 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0057 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0041 0.0288 0.0272
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0267 0.0251
Echinococcus multilocularis calpain A 0.0056 0.0452 0.0436
Onchocerca volvulus Prolyl endopeptidase homolog 0.0904 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0261 0.0245
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0052 0.0052
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.005 0.0384 0.0368
Schistosoma mansoni alpha glucosidase 0.0038 0.025 0.025
Trypanosoma brucei calpain-like protein, putative 0.002 0.0052 0.0052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0503 0.0487
Echinococcus multilocularis calpain 0.002 0.0052 0.0036
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.025 0.0684
Brugia malayi hypothetical protein 0.0246 0.2593 0.2581
Brugia malayi PHD-finger family protein 0.0025 0.0109 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Echinococcus multilocularis RUN 0.002 0.0057 0.0041
Leishmania major GTP-binding protein, putative 0.0021 0.006 0.006
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.0127
Brugia malayi prolyl oligopeptidase family protein 0.0095 0.0894 0.0879
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0904 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.1065 0.1065
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0452 0.0436
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0904 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.025 0.025
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2593 0.2581
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0095 0.0894 0.0879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0095 0.0894 0.0894
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.025 0.025
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2593 0.2581
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0036 0.002
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0359 0.3872 0.3872
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.025 0.0234
Loa Loa (eye worm) prolyl oligopeptidase 0.0095 0.0894 0.0879
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.006
Onchocerca volvulus 0.002 0.0057 0.0041
Echinococcus granulosus prolyl endopeptidase 0.0904 1 1
Echinococcus granulosus calpain 7 C02 family 0.002 0.0052 0.0036
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0082 0.0082
Entamoeba histolytica hypothetical protein, conserved 0.0095 0.0894 0.257
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0036 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.1349 0.1335
Echinococcus multilocularis hypothetical protein 0.002 0.0052 0.0036
Schistosoma mansoni calpain (C02 family) 0.002 0.0052 0.0052
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.3206 0.3195
Brugia malayi hypothetical protein 0.005 0.0386 0.037
Echinococcus multilocularis zinc finger protein 0.002 0.0048 0.0032
Trichomonas vaginalis inositol monophosphatase, putative 0.011 0.1065 0.3071
Schistosoma mansoni rab6-interacting 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0071 0.0628 0.0612
Schistosoma mansoni hypothetical protein 0.0345 0.371 0.371
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0016 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0549 0.0549
Trypanosoma brucei calpain-like protein, putative 0.002 0.0052 0.0052
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.032 0.343 0.3419
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0031 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1349 0.1335
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.025 0.0684
Schistosoma mansoni alpha-glucosidase 0.0146 0.1468 0.1468
Trypanosoma cruzi oligopeptidase b 0.0359 0.3872 0.3872
Plasmodium falciparum plasmepsin IV 0.005 0.0384 0.1077
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.025 0.0684
Schistosoma mansoni hypothetical protein 0.005 0.0391 0.0391
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.025 0.0684
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0095 0.0894 0.0894
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0248 0.0232
Echinococcus granulosus calpain A 0.002 0.0052 0.0036
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.006 0.0044
Brugia malayi Pre-SET motif family protein 0.0216 0.2262 0.2249
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0052 0.0052
Plasmodium vivax plasmepsin IV, putative 0.005 0.0384 0.1077
Schistosoma mansoni cathepsin D (A01 family) 0.0146 0.147 0.147
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0078 0.0061
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0095 0.0894 0.0879
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0036 0.002
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0095 0.0894 0.0879
Brugia malayi Importin beta-1 subunit 0.0028 0.0143 0.0127
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.006 0.0043
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.025 0.0684
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.025 0.0684
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.1733 0.1719
Loa Loa (eye worm) hypothetical protein 0.0039 0.0267 0.0251
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0452 0.0452
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0095 0.0894 0.0879
Schistosoma mansoni rab6-interacting 0.002 0.0057 0.0057
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0057 0.0041
Trypanosoma cruzi oligopeptidase b 0.0359 0.3872 0.3872
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1349 0.1349
Plasmodium falciparum plasmepsin I 0.005 0.0384 0.1077
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0083 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.011 0.1065 0.105
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0809 0.8933 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0452 0.0452
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.032 0.343 0.343
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0248 0.0248
Onchocerca volvulus 0.005 0.0391 0.0375
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0095 0.0894 0.0879
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1349 0.1335
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.1065 0.1065
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0057 0.0041
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0487 0.0487
Onchocerca volvulus 0.0246 0.2598 0.2586
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.025 0.0684
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0176 0.016
Echinococcus granulosus eukaryotic initiation factor 4A 0.032 0.343 0.3419
Toxoplasma gondii prolyl endopeptidase 0.0904 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0016
Plasmodium falciparum importin beta, putative 0.0028 0.0143 0.0372
Echinococcus multilocularis eukaryotic initiation factor 4A 0.032 0.343 0.3419
Entamoeba histolytica hypothetical protein 0.0023 0.0083 0.0196
Leishmania major eukaryotic initiation factor 4a, putative 0.032 0.343 0.343
Leishmania major hypothetical protein, conserved 0.005 0.0386 0.0386
Trypanosoma brucei prolyl oligopeptidase, putative 0.0359 0.3872 0.3872
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0036 0.0059
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2598 0.7564
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0095 0.0894 0.0894
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0037 0.0248 0.0678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Entamoeba histolytica prolyl oligopeptidase family protein 0.0095 0.0894 0.257
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0036 0.0059
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0095 0.0894 0.0894
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0359 0.3872 0.3872
Schistosoma mansoni loxhd1 0.002 0.0057 0.0057
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.032 0.343 1
Schistosoma mansoni hypothetical protein 0.0345 0.371 0.371
Loa Loa (eye worm) hypothetical protein 0.0028 0.0143 0.0127
Echinococcus multilocularis inositol monophosphatase 1 0.011 0.1065 0.105
Echinococcus granulosus eukaryotic initiation factor 4A III 0.032 0.343 0.3419
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.0043
Brugia malayi calpain family protein 1 0.0053 0.0425 0.0409
Entamoeba histolytica prolyl oligopeptidase family protein 0.0095 0.0894 0.257
Echinococcus multilocularis calpain 5 0.002 0.0052 0.0036
Trypanosoma cruzi prolyl endopeptidase 0.0904 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0016
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0095 0.0894 0.0894
Trypanosoma brucei prolyl endopeptidase 0.0904 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0248 0.0248
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0359 0.3872 0.4312
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0395 0.0395
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.025 0.0684
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0143 0.0143
Brugia malayi prolyl oligopeptidase family protein 0.0095 0.0894 0.0879
Loa Loa (eye worm) aspartic protease BmAsp-2 0.005 0.0384 0.0368
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0048 0.0369 0.0353
Loa Loa (eye worm) hypothetical protein 0.0095 0.0894 0.0879
Trypanosoma brucei oligopeptidase b 0.0359 0.3872 0.3872
Brugia malayi Pre-SET motif family protein 0.0031 0.0176 0.016
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0052 0.0052
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.032 0.343 1
Entamoeba histolytica Ran family GTPase 0.0021 0.006 0.0127
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0549 0.0549
Leishmania major cathepsin L-like protease 0.0064 0.0549 0.0549
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0549 0.0549
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.006 0.0127
Schistosoma mansoni inositol monophosphatase 0.011 0.1065 0.1065
Entamoeba histolytica hypothetical protein 0.0037 0.0248 0.0678
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0095 0.0894 0.257
Schistosoma mansoni lipoxygenase 0.002 0.0057 0.0057
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0095 0.0894 0.257
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0052 0.0052
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.011 0.1065 0.2681
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.0425 0.0425
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0246 0.2593 0.2581
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0143 0.0127
Trichomonas vaginalis myo inositol monophosphatase, putative 0.011 0.1065 0.3071
Plasmodium vivax calpain, putative 0.002 0.0052 0.0106
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.032 0.343 0.343
Trypanosoma brucei calpain-like protein, putative 0.002 0.0052 0.0052
Onchocerca volvulus 0.0018 0.0031 0.0014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.0043
Leishmania major cathepsin L-like protease 0.0064 0.0549 0.0549
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0052 0.0052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.011 0.1065 0.3071
Plasmodium falciparum plasmepsin VI 0.005 0.0384 0.1077
Entamoeba histolytica prolyl oligopeptidase family protein 0.0095 0.0894 0.257
Echinococcus granulosus zinc finger protein 0.002 0.0048 0.0032
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0031 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0083 0.0196
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0027 0.001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.025 0.0684
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0057 0.012
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.032 0.343 1
Trypanosoma brucei glucosidase, putative 0.0038 0.025 0.025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0036 0.0059
Echinococcus granulosus geminin 0.0345 0.371 0.3699
Echinococcus granulosus Dipeptidyl peptidase 9 0.0095 0.0894 0.0879
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0041
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0386 0.1083
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.006 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0031 0.0031
Echinococcus granulosus calpain 0.002 0.0052 0.0036
Schistosoma mansoni lipoxygenase 0.0057 0.0473 0.0473
Trichomonas vaginalis ran, putative 0.0021 0.006 0.0127
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.025 0.0684
Schistosoma mansoni hypothetical protein 0.03 0.3206 0.3206
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.032 0.343 0.3814
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.1733 0.1719
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0057 0.0041
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.011 0.1065 0.1065
Brugia malayi hypothetical protein 0.0032 0.0188 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.005 0.0384 0.0368
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0386 0.0386
Entamoeba histolytica hypothetical protein 0.0037 0.0248 0.0678
Onchocerca volvulus 0.002 0.0057 0.0041
Schistosoma mansoni ap endonuclease 0.0019 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0047 0.0357 0.0341
Brugia malayi hypothetical protein 0.002 0.0057 0.0041
Loa Loa (eye worm) prolyl oligopeptidase 0.0095 0.0894 0.0879
Loa Loa (eye worm) hypothetical protein 0.005 0.0386 0.037
Leishmania major oligopeptidase b 0.0359 0.3872 0.3872
Loa Loa (eye worm) hypothetical protein 0.032 0.343 0.3419
Brugia malayi Doublecortin family protein 0.002 0.0057 0.0041
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0098 0.0935 0.101
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0031 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Brugia malayi calpain 7 0.002 0.0052 0.0036
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0052 0.0052
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0016
Brugia malayi hypothetical protein 0.002 0.0057 0.0041
Loa Loa (eye worm) hypothetical protein 0.0904 1 1
Echinococcus granulosus calpain 5 0.002 0.0052 0.0036
Schistosoma mansoni ap endonuclease 0.0019 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0037 0.0248 0.0678
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.032 0.343 0.343
Schistosoma mansoni calpain C (C02 family) 0.002 0.0052 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0248 0.0232
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0016 0.0016
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.005 0.0384 0.0368
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0176 0.016
Schistosoma mansoni ran 0.0021 0.006 0.006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0234 0.0218
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.005 0.0384 0.1077
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0143 0.0127
Toxoplasma gondii aspartyl protease ASP1 0.005 0.0384 0.0368
Brugia malayi hypothetical protein 0.0037 0.0248 0.0232
Schistosoma mansoni hypothetical protein 0.0021 0.006 0.006
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.032 0.343 0.343
Schistosoma mansoni importin beta-1 0.0028 0.0143 0.0143
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0078 0.0061
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0031 0.0014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0052 0.0052
Leishmania major eukaryotic initiation factor 4a, putative 0.032 0.343 0.343
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0095 0.0894 0.0894
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0016
Toxoplasma gondii hypothetical protein 0.0095 0.0894 0.0879
Schistosoma mansoni alpha-glucosidase 0.0146 0.1468 0.1468
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.002 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0384 0.0384
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0036 0.0059
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.006
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0095 0.0894 0.257
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0095 0.0894 0.0894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1349 0.1335
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0267 0.0251
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0095 0.0894 0.257
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0894 0.0894
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0359 0.3872 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0052 0.0052
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0452 0.0436
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0057
Toxoplasma gondii exonuclease III APE 0.0019 0.0036 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0391 0.0375
Plasmodium falciparum plasmepsin II 0.005 0.0384 0.1077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0176 0.0176
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0057 0.0041
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.002 0.002
Brugia malayi calpain family protein 1 0.0053 0.0425 0.0409
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0549 0.0549
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0095 0.0894 0.0894
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0082 0.0066
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0473 0.0457
Leishmania major cathepsin L-like protease 0.0064 0.0549 0.0549
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0052 0.0052
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0016 0.0016
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.1733 0.1719
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0386 0.037
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0016 0.0016
Brugia malayi Inositol-1 0.011 0.1065 0.105
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0052 0.0052
Loa Loa (eye worm) doublecortin family protein 0.002 0.0057 0.0041
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0057 0.0041
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0036 0.002
Brugia malayi prolyl oligopeptidase family protein 0.0095 0.0894 0.0879
Schistosoma mansoni bromodomain containing protein 0.0064 0.0544 0.0544
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0036 0.0036
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0036 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0033 0.0199 0.0183
Trypanosoma brucei calpain-like protein, putative 0.002 0.0052 0.0052
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0369 0.0353
Echinococcus granulosus RUN 0.002 0.0057 0.0041
Schistosoma mansoni zinc finger protein 0.002 0.0048 0.0048
Mycobacterium tuberculosis Probable peptidase 0.0359 0.3872 0.4312
Schistosoma mansoni polycystin 1-related 0.002 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0031 0.0042
Schistosoma mansoni ran 0.0021 0.006 0.006
Giardia lamblia Translation initiation factor eIF-4A, putative 0.032 0.343 1
Brugia malayi prolyl oligopeptidase family protein 0.0095 0.0894 0.0879
Brugia malayi eukaryotic initiation factor 4A 0.032 0.343 0.3419
Brugia malayi Protein kinase domain containing protein 0.0018 0.0031 0.0014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0843 0.9315 0.9313
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.011 0.1065 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.025 0.025
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0359 0.3872 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0163 0.0147
Giardia lamblia Alanyl dipeptidyl peptidase 0.0095 0.0894 0.2526

Activities

Activity type Activity value Assay description Source Reference
KA (binding) = 0.875 uM Inhibition of human Carbonic anhydrase I, using histamine as standard ChEMBL. 11784154
KA (binding) = 0.875 uM Inhibition of human Carbonic anhydrase I, using histamine as standard ChEMBL. 11784154
KA (binding) = 1.68 uM Bovine Carbonic anhydrase IV activity using histamine as standard ChEMBL. 11784154
KA (binding) = 1.68 uM Bovine Carbonic anhydrase IV activity using histamine as standard ChEMBL. 11784154
KA (binding) = 83 uM Inhibition of human Carbonic anhydrase II, using histamine as standard ChEMBL. 11784154
KA (binding) = 83 uM Inhibition of human Carbonic anhydrase II, using histamine as standard ChEMBL. 11784154

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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