Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.2406 | 0.2406 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0405 | 1 | 0.5 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0314 | 0.7276 | 0.7276 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0153 | 0.2406 | 0.2406 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0405 | 1 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0405 | 1 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0153 | 0.2406 | 0.2406 |
Brugia malayi | glycyl-tRNA synthetase | 0.0314 | 0.7276 | 0.7276 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0405 | 1 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0405 | 1 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0405 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.2406 | 0.2406 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0314 | 0.7276 | 0.7276 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0314 | 0.7276 | 0.7276 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.2406 | 0.2406 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.034 | 0.8057 | 0.8057 |
Onchocerca volvulus | 0.0073 | 0 | 0.5 | |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0314 | 0.7276 | 0.7276 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0314 | 0.7276 | 0.7276 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.2406 | 0.2406 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0314 | 0.7276 | 0.7276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]-8-OH-DPAT from rat hippocampus membranes | ChEMBL. | 14640559 |
IC50 (binding) | > 1000 nM | Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes | ChEMBL. | 14640559 |
IC50 (binding) | > 1000 nM | Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]-8-OH-DPAT from rat hippocampus membranes | ChEMBL. | 14640559 |
IC50 (binding) | > 1000 nM | Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes | ChEMBL. | 14640559 |
Ki (binding) | = 134.3 nM | Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]-paroxetine in male wistar rats | ChEMBL. | 14640559 |
Ki (binding) | = 134.3 nM | Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]-paroxetine in male wistar rats | ChEMBL. | 14640559 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.