Detailed information for compound 262591

Basic information

Technical information
  • TDR Targets ID: 262591
  • Name: [1-(tert-butylamino)-3-[(2-methyl-1H-indol-4- yl)oxy]propan-2-yl] benzoate
  • MW: 380.48 | Formula: C23H28N2O3
  • H donors: 2 H acceptors: 1 LogP: 4.59 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)OC(COc1cccc2c1cc([nH]2)C)CNC(C)(C)C
  • InChi: 1S/C23H28N2O3/c1-16-13-19-20(25-16)11-8-12-21(19)27-15-18(14-24-23(2,3)4)28-22(26)17-9-6-5-7-10-17/h5-13,18,24-25H,14-15H2,1-4H3
  • InChiKey: UUOJIACWOAYWEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-[(tert-butylamino)methyl]-2-[(2-methyl-1H-indol-4-yl)oxy]ethyl] benzoate
  • benzoic acid [1-[(tert-butylamino)methyl]-2-[(2-methyl-1H-indol-4-yl)oxy]ethyl] ester
  • bopindolol
  • 62658-63-3
  • 69010-88-4
  • 2-[(1,1-dimethylethyl)amino]-1-{[(2-methyl-1H-indol-4-yl)oxy]methyl}ethyl benzoate
  • NCGC00163155-01
  • (+-)-1-((1,1-Dimethylethyl)amino)-3-((2-methyl-1H-indol-4-yl)oxy)-2-propanol benzoate (ester)
  • (+-)-1-(tert-Butylamino)-3-((2-methylindol-4-yl)oxy)-2-propanol benzoate (ester)
  • (+-)-4-(2-Benzoyloxy-3-tert-butylaminopropoxy)-2-methylindole
  • (+-)-Bopindolol
  • 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((2-methyl-1H-indol-4-yl)oxy)-, benzoate (ester), (+-)-
  • Bopindolol [USAN:INN]
  • Bopindololum [INN-Latin]
  • Wandonorm
  • LT-31200

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 3 Starlite/ChEMBL No references
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Starlite/ChEMBL No references
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 1 Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Brugia malayi hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) blistered cuticle protein 3 0.0155 0.1734 0.4779
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0015 0.0015
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0119 0.0119
Schistosoma mansoni peroxidasin 0.0155 0.1734 0.5079
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.032 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0119 0.0349
Brugia malayi RE15519p 0.0019 0.0119 0.0349
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0119 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.032 0.0889
Echinococcus granulosus protein cereblon 0.0297 0.3414 0.3414
Echinococcus multilocularis protein cereblon 0.0297 0.3414 0.3492
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0119 0.0119
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0015 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Schistosoma mansoni adenoreceptor 0.0019 0.0119 0.0349
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0015
Schistosoma mansoni histamine h1 receptor 0.0019 0.0119 0.0349
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0119 0.0122
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0015 0.0015
Onchocerca volvulus Peroxidasin homolog 0.0155 0.1734 0.5057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0346 0.0346
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0119 0.0122
Echinococcus granulosus g protein coupled receptor 0.0019 0.0119 0.0119
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1497 0.4383
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0119 0.0122
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0324 0.5073
Loa Loa (eye worm) hypothetical protein 0.0166 0.1863 0.5133
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0153 0.1913
Echinococcus granulosus biogenic amine 5HT receptor 0.0166 0.1863 0.1863
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1378 0.1409
Brugia malayi Peroxidasin 0.0155 0.1734 0.5079
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0119 0.0328
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0324 0.0331
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0015 0.0045
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0119 0.0119
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0015 0.0045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2603 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0042
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0153 0.2404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0119 0.0122
Mycobacterium tuberculosis Conserved protein 0.0036 0.032 0.068
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0119 0.0119
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0016
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.0638 0.0638
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.032 0.068
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0119 0.0349
Onchocerca volvulus 0.0019 0.0119 0.0306
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Loa Loa (eye worm) animal heme peroxidase 0.0155 0.1734 0.4779
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0119 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0119 0.0349
Plasmodium vivax SET domain protein, putative 0.0036 0.0324 0.4504
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0153 0.1913
Schistosoma mansoni biogenic amine receptor 0.0019 0.0119 0.0349
Brugia malayi Animal haem peroxidase family protein 0.0155 0.1734 0.5079
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0673 0.0673
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.032 0.0937
Toxoplasma gondii thioredoxin reductase 0.0063 0.0638 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0153 0.1913
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Plasmodium vivax hypothetical protein, conserved 0.0036 0.032 0.4438
Onchocerca volvulus 0.0019 0.0119 0.0306
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Schistosoma mansoni biogenic amine receptor 0.0019 0.0119 0.0349
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0673 1
Brugia malayi Pre-SET motif family protein 0.0251 0.2876 0.8424
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0119 0.0349
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0119 0.0122
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0673 0.1971
Schistosoma mansoni biogenic amine (5HT) receptor 0.0166 0.1863 0.5456
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0673 0.1971
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0119 0.0122
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.032 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Onchocerca volvulus 0.0036 0.0324 0.0908
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0119 0.0122
Toxoplasma gondii ABC1 family protein 0.0036 0.032 0.5014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0673 0.1855
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0153 0.1913
Plasmodium falciparum glutathione reductase 0.0022 0.0153 0.2404
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.032 0.068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Plasmodium falciparum thioredoxin reductase 0.0022 0.0153 0.2404
Onchocerca volvulus 0.0019 0.0119 0.0306
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0119 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0045
Loa Loa (eye worm) beta-lactamase 0.0036 0.032 0.0882
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2876 0.7926
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0015 0.0016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Schistosoma mansoni opsin-like receptor 0.0019 0.0119 0.0349
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0119 0.0122
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0015
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0015 0.0045
Schistosoma mansoni hypothetical protein 0.0019 0.0119 0.0349
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0673 1
Brugia malayi hypothetical protein 0.0297 0.3414 1
Onchocerca volvulus 0.0019 0.0119 0.0306
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0119 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0042
Mycobacterium leprae conserved hypothetical protein 0.0036 0.032 1
Brugia malayi Serotonin receptor 0.0019 0.0119 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0153 0.1913
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0119 0.0349
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0119 0.0119
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0119 0.0119
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0153 0.1913
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.032 0.068
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.032 0.032
Onchocerca volvulus 0.0019 0.0119 0.0306
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0042
Echinococcus multilocularis serotonin receptor 0.0166 0.1863 0.1905
Brugia malayi Dopamine receptor protein 2 0.0019 0.0119 0.0349
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.032 0.068
Brugia malayi larval opioid receptor 0.0019 0.0119 0.0349
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0119 0.0122
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0119 0.0122
Brugia malayi Dopamine receptor protein 1 0.0019 0.0119 0.0349
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.9777 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0673 1
Brugia malayi ecdysteroid receptor 0.001 0.0015 0.0045
Treponema pallidum NADH oxidase 0.0022 0.0153 0.5
Echinococcus granulosus g protein coupled receptor 0.0019 0.0119 0.0119
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Entamoeba histolytica hypothetical protein, conserved 0.0297 0.3414 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Brugia malayi Animal haem peroxidase family protein 0.0155 0.1734 0.5079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0045
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0119 0.0119
Leishmania major hypothetical protein, conserved 0.0036 0.032 0.4505
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0119 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0045
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0153 0.5
Brugia malayi Animal haem peroxidase family protein 0.0155 0.1734 0.5079
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1378 0.1378
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0119 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.032 0.0889
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Onchocerca volvulus 0.0019 0.0119 0.0306
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0119 0.0122
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0153 0.1913
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0119 0.0328
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Schistosoma mansoni coup transcription factor 0.001 0.0015 0.0045
Mycobacterium ulcerans beta-lactamase 0.0036 0.032 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0153 0.0449
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0324 0.0331
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0119 0.0122
Onchocerca volvulus 0.0019 0.0119 0.0306
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0119 0.0328
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0153 0.0449
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0015 0.0016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0119 0.0122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.032 0.0937
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Trichomonas vaginalis esterase, putative 0.0036 0.032 0.0889
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0119 0.0349
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0119 0.0349
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0119 0.0119
Plasmodium vivax glutathione reductase, putative 0.0063 0.0638 1
Echinococcus granulosus geminin 0.0168 0.189 0.189
Onchocerca volvulus Protein cereblon homolog 0.0297 0.3414 1
Plasmodium falciparum glutathione reductase 0.0063 0.0638 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0673 0.1899
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0153 0.1913
Echinococcus granulosus serotonin receptor 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0153 0.1526
Brugia malayi follicle stimulating hormone receptor 0.0247 0.2826 0.8276
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0119 0.0122
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Onchocerca volvulus 0.0019 0.0119 0.0306
Onchocerca volvulus 0.0155 0.1734 0.5057
Brugia malayi putative neuropeptide receptor 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0315 0.3629 1
Brugia malayi hypothetical protein 0.0121 0.1329 0.3891
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0119 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.032 0.0882
Mycobacterium ulcerans lipase LipD 0.0036 0.032 1
Schistosoma mansoni amine GPCR 0.0019 0.0119 0.0349
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0119 0.0349
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0119 0.0122
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0324 0.0948
Schistosoma mansoni hypothetical protein 0.0168 0.189 0.5536
Onchocerca volvulus Dual oxidase homolog 0.0155 0.1734 0.5057
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0119 0.0306
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0016
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0119 0.0119
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.2826 0.7786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Brugia malayi neuropeptide F receptor 0.0019 0.0119 0.0349
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0119 0.0328
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0119 0.0122
Brugia malayi Serotonin receptor 0.0019 0.0119 0.0349
Schistosoma mansoni amine GPCR 0.0019 0.0119 0.0349
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0119 0.0349
Brugia malayi steroid hormone receptor 0.001 0.0015 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0045
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) RecQ helicase 0.0021 0.0147 0.0406
Brugia malayi G-protein coupled receptor 0.0019 0.0119 0.0349
Schistosoma mansoni amine GPCR 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Brugia malayi GnHR receptor homolog 0.0019 0.0119 0.0349
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.032 0.0882
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.0638 0.1979
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0324 0.0324
Trypanosoma brucei trypanothione reductase 0.0063 0.0638 0.9457
Brugia malayi Animal haem peroxidase family protein 0.0155 0.1734 0.5079
Echinococcus granulosus allatostatin A receptor 0.0019 0.0119 0.0119
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0119 0.0349
Brugia malayi Animal haem peroxidase family protein 0.0155 0.1734 0.5079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0119 0.0328
Mycobacterium tuberculosis Conserved protein 0.0036 0.032 0.068
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0119 0.0119
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0119 0.0328
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3288 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.032 0.0889
Schistosoma mansoni neuropeptide receptor 0.0019 0.0119 0.0349
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0119 0.0122
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0119 0.0349
Echinococcus granulosus FTZ F1 alpha 0.001 0.0015 0.0015
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0119 0.0328
Brugia malayi Pre-SET motif family protein 0.0036 0.0324 0.0948
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0153 0.0153
Onchocerca volvulus 0.0019 0.0119 0.0306
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0119 0.0349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0119 0.0122
Schistosoma mansoni hypothetical protein 0.0019 0.0119 0.0349
Onchocerca volvulus Chorion peroxidase homolog 0.0155 0.1734 0.5057
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0119 0.0328
Onchocerca volvulus 0.0019 0.0119 0.0306
Echinococcus multilocularis geminin 0.0168 0.189 0.1933
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0015 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0324 0.0948
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0119 0.0122
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0064 0.1005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Onchocerca volvulus 0.0036 0.032 0.0896
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0119 0.0306
Loa Loa (eye worm) hypothetical protein 0.0166 0.1863 0.5133
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Loa Loa (eye worm) hypothetical protein 0.0036 0.032 0.0882
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0119 0.0119
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0673 1
Onchocerca volvulus 0.0019 0.0119 0.0306
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0015 0.0045
Brugia malayi beta-lactamase family protein 0.0036 0.032 0.0937
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0119 0.0122
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1497 0.4383
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0119 0.0349
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0119 0.0122
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0119 0.0122
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.032 0.068
Schistosoma mansoni amine GPCR 0.0019 0.0119 0.0349
Echinococcus multilocularis peroxidasin 0.0155 0.1734 0.1774
Echinococcus granulosus sex peptide receptor 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Mycobacterium tuberculosis Conserved protein 0.0036 0.032 0.068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0324 0.0948
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0095 0.0277
Schistosoma mansoni opsin-like receptor 0.0019 0.0119 0.0349
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Echinococcus granulosus neuropeptide receptor 0.0019 0.0119 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0042
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.0638 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0119 0.0122
Onchocerca volvulus 0.0019 0.0119 0.0306
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0119 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0119 0.0122
Onchocerca volvulus 0.0019 0.0119 0.0306
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0015 0.0045
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0119 0.0349
Onchocerca volvulus 0.0155 0.1734 0.5057
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0673 0.0688
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0042
Loa Loa (eye worm) animal heme peroxidase 0.0155 0.1734 0.4779
Onchocerca volvulus Peroxidasin homolog 0.0155 0.1734 0.5057
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0036 0.032 0.0882
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.032 0.4505
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0346 0.0354
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.032 0.0882
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus granulosus orexin receptor type 2 0.0019 0.0119 0.0119
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.032 0.068
Schistosoma mansoni amine GPCR 0.0019 0.0119 0.0349
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0153 0.1526
Onchocerca volvulus 0.0019 0.0119 0.0306
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0119 0.0119
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0153 0.0377
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0085 0.0249
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0119 0.0119
Onchocerca volvulus 0.0019 0.0119 0.0306
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0119 0.0349
Echinococcus granulosus neuropeptide receptor 0.0019 0.0119 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0015
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0119 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0016
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0119 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus multilocularis somatostatin receptor 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0119 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0153 0.1913
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0308 0.0308
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0153 0.2404
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0119 0.0349
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0324 0.0948
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0119 0.0328
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0119 0.0119
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0153 0.1913
Schistosoma mansoni opsin-like receptor 0.0019 0.0119 0.0349
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0153 0.5
Loa Loa (eye worm) glutathione reductase 0.0063 0.0638 0.1758
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.032 0.4505
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0019 0.0119 0.0349
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0119 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0119 0.0122
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.032 0.0327
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0153 0.2404
Brugia malayi Blistered cuticle protein 3 0.0155 0.1734 0.5079
Brugia malayi Dopamine receptor 0.0019 0.0119 0.0349
Brugia malayi AKH receptor 0.0019 0.0119 0.0349
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0119 0.0349
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0119 0.0349
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Echinococcus granulosus somatostatin receptor 0.0019 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0062 0.0637 0.1865
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.032 0.0937
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.032 0.0889
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Brugia malayi beta-lactamase family protein 0.0036 0.032 0.0937
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0015 0.0045
Onchocerca volvulus 0.0019 0.0119 0.0306
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0147 0.0359
Echinococcus granulosus peroxidasin 0.0155 0.1734 0.1734
Mycobacterium leprae Probable lipase LipE 0.0036 0.032 1
Echinococcus multilocularis sex peptide receptor 0.0019 0.0119 0.0122
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0153 0.2404
Loa Loa (eye worm) hypothetical protein 0.0036 0.0324 0.0892
Brugia malayi G protein-coupled receptor 0.0019 0.0119 0.0349
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.032 0.0889
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0119 0.0119
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0119 0.0122
Loa Loa (eye worm) animal heme peroxidase 0.0155 0.1734 0.4779
Schistosoma mansoni neuropeptide receptor 0.0019 0.0119 0.0349
Plasmodium falciparum thioredoxin reductase 0.0063 0.0638 1
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0119 0.0122
Onchocerca volvulus 0.0036 0.032 0.0896
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0015 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0119 0.0349
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0015 0.0045
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0153 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) hypothetical protein 0.0036 0.032 0.0882
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0015
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.1497 0.1531
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.032 0.4505
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0119 0.0122
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0119 0.0349
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.0638 0.0653
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0153 0.1913
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0045
Echinococcus multilocularis serotonin receptor 0.0166 0.1863 0.1905
Brugia malayi sulfakinin receptor protein 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0153 0.1913
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0153 0.1913
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0119 0.0119
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0015 0.0042
Onchocerca volvulus 0.0019 0.0119 0.0306
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0042
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0153 0.0377
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0153 1
Schistosoma mansoni hypothetical protein 0.0019 0.0119 0.0349
Schistosoma mansoni hypothetical protein 0.0168 0.189 0.5536
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0266
Brugia malayi hypothetical protein 0.0019 0.0119 0.0349
Brugia malayi ORL1-like opioid receptor 0.0019 0.0119 0.0349
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0119 0.0119
Echinococcus granulosus bloom syndrome protein 0.0021 0.0147 0.0147
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0119 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0042
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0638 0.9457
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0153 0.0157
Brugia malayi Melatonin receptor type 1A 0.0019 0.0119 0.0349
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0117 0.1832
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0119 0.0122
Leishmania major trypanothione reductase 0.0063 0.0638 0.9457
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0119 0.0119
Schistosoma mansoni neuropeptide receptor 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0297 0.3414 0.9408
Schistosoma mansoni biogenic amine receptor 0.0019 0.0119 0.0349
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0153 0.1913
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Schistosoma mansoni hypothetical protein 0.0125 0.1378 0.4035
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0119 0.0328
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0015 0.0015
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0147 0.0359
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0153 0.1913
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0119 0.0119
Onchocerca volvulus 0.0036 0.032 0.0896
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0153 0.1913
Onchocerca volvulus 0.0155 0.1734 0.5057
Brugia malayi G-protein coupled receptor 0.0019 0.0119 0.0349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0153 0.1913
Schistosoma mansoni peroxidasin 0.0155 0.1734 0.5079
Onchocerca volvulus Peroxidase homolog 0.0155 0.1734 0.5057
Loa Loa (eye worm) hypothetical protein 0.0036 0.032 0.0882
Mycobacterium ulcerans hypothetical protein 0.0036 0.032 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Brugia malayi beta-lactamase 0.0036 0.032 0.0937
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0119 0.0122
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779
Brugia malayi hypothetical protein 0.0155 0.1734 0.5079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Loa Loa (eye worm) animal heme peroxidase 0.0155 0.1734 0.4779
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Onchocerca volvulus Peroxidase homolog 0.0155 0.1734 0.5057
Schistosoma mansoni hypothetical protein 0.0297 0.3414 1
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0147 0.0151
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0042
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.0638 0.1758
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0119 0.0119
Echinococcus granulosus fmrfamide receptor 0.0019 0.0119 0.0119
Brugia malayi Thioredoxin reductase 0.0063 0.0638 0.1869
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0119 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0328
Schistosoma mansoni myosin xvIII 0.0019 0.0119 0.0349
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0147 0.0432
Brugia malayi glutathione reductase 0.0063 0.0638 0.1869
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0045
Brugia malayi neuropeptide F receptor 0.0019 0.0119 0.0349
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0045
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0119 0.0349
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0085 0.0249
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0045
Echinococcus granulosus g protein coupled receptor 0.0019 0.0119 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0042
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.032 0.068
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0015 0.0045
Onchocerca volvulus 0.0286 0.3288 0.9628
Schistosoma mansoni neuropeptide receptor 0.0019 0.0119 0.0349
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0155 0.1734 0.4779

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 7.8 Beta-blocking activity of the compound was measured by applying the stepwise linear discriminate analysis; Active ChEMBL. No reference
Activity (functional) = 7.8 Beta-blocking activity of the compound was measured by applying the stepwise linear discriminate analysis; Active ChEMBL. No reference
EC50 (functional) = 40 uM Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay ChEMBL. 20547819
IC50 (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
IC50 (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
IC50 (binding) = 0.02 uM DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
IC50 (binding) = 0.047 uM DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) = 0.267 uM DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
IC50 (binding) = 0.458 uM DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
IC50 (binding) = 1.523 uM DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
IC50 (binding) = 1.581 uM DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
IC50 (binding) = 5.4764 uM DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Chemokine CXCR1 (IL-8A) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) ChEMBL. No reference
Ki (binding) DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) ChEMBL. No reference
Ki (binding) = 0.014 uM DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) ChEMBL. No reference
Ki (binding) = 0.027 uM DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) = 0.153 uM DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ChEMBL. No reference
Ki (binding) = 0.344 uM DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) ChEMBL. No reference
Ki (binding) = 0.452 uM DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) ChEMBL. No reference
Ki (binding) = 0.969 uM DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) ChEMBL. No reference
LD50 (ADMET) 0 mg kg-1 Compound was tested for its toxicity after oral administration to mice in experiment 1; No data ChEMBL. No reference
LD50 (ADMET) 0 mg kg-1 Compound was tested for its toxicity after oral administration to mice in experiment 2; No data ChEMBL. No reference
LD50 (ADMET) = 15.9 mg kg-1 Compound was tested for its toxicity after intravenous administration to mice in experiment 2 ChEMBL. No reference
LD50 (ADMET) = 17 mg kg-1 Compound was tested for its toxicity after intravenous administration to mice in experiment 1 ChEMBL. No reference
Potency (functional) 9.5283 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 18.1056 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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