Detailed information for compound 279372

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 311.378 | Formula: C18H21N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCOc1cc(OC)ccc1c1nc2c(n1)cc[nH]c2
  • InChi: 1S/C18H21N3O2/c1-3-4-5-10-23-17-11-13(22-2)6-7-14(17)18-20-15-8-9-19-12-16(15)21-18/h6-9,11-12,19H,3-5,10H2,1-2H3
  • InChiKey: GPZQFILJHATXDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi C-8 sterol isomerase, putative 0.6311 1 1
Brugia malayi RE15519p 0.0018 0.0011 0.0009
Echinococcus multilocularis serotonin receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0058 0.0049
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0011 0.0002
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0011 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0011 0.0004
Onchocerca volvulus 0.0137 0.02 0.0329
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0323
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.016 0.0236 0.0227
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0357 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0357 0.0607
Echinococcus granulosus serotonin receptor 0.0018 0.0011 0.0004
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0011 0.0009
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0025 0.3821
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.003 0.4757
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0011 0.0004
Leishmania major trypanothione reductase 0.0048 0.0058 0.0058
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0011 0.0004
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0013 0.0004
Loa Loa (eye worm) glutathione reductase 0.0048 0.0058 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0011 0.0004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0011 0.0009
Leishmania major DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Schistosoma mansoni opsin-like receptor 0.0018 0.0011 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0008 0.066
Brugia malayi ORL1-like opioid receptor 0.0018 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.6311 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0008
Schistosoma mansoni neuropeptide receptor 0.0018 0.0011 0.0004
Brugia malayi Dopamine receptor protein 2 0.0018 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0016
Brugia malayi Serotonin receptor 0.0018 0.0011 0.0009
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.003 0.0038
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0008 0.0707
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0011 0.0004
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.0025 0.0024
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0011 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0025 0.379
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0011 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0013 0.0013
Schistosoma mansoni biogenic amine receptor 0.0018 0.0011 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0191 0.0285 0.0277
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.003 0.0038
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0156 0.8837
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0011 0.0004
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0011 0.0004
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0008 0.0229
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0028 0.0035
Onchocerca volvulus 0.0048 0.0058 0.0083
Toxoplasma gondii hypothetical protein 0.0027 0.0025 0.3821
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0011 0.0004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0025 0.0029
Echinococcus granulosus bloom syndrome protein 0.0021 0.0016 0.0013
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Onchocerca volvulus 0.016 0.0236 0.0392
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0025 0.0029
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0004
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0011
Toxoplasma gondii thioredoxin reductase 0.0048 0.0058 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0058 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.0025 0.0029
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0011 0.0002
Echinococcus granulosus orexin receptor type 2 0.0018 0.0011 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0011 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Brugia malayi glutathione reductase 0.0048 0.0058 0.0057
Echinococcus granulosus sex peptide receptor 0.0018 0.0011 0.0004
Brugia malayi hypothetical protein 0.0027 0.0025 0.0024
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0012 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0058 0.0087
Plasmodium falciparum transporter, putative 0.0027 0.0025 0.3351
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0013 0.0007
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0376 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Plasmodium vivax SET domain protein, putative 0.003 0.003 0.473
Trypanosoma brucei Emopamil binding protein, putative 0.0137 0.02 0.02
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0025 0.0016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0012 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0011 0.0004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0011 0.0004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0156 0.8837
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0012 0.0006
Brugia malayi G protein-coupled receptor 0.0018 0.0011 0.0009
Schistosoma mansoni biogenic amine receptor 0.0018 0.0011 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Schistosoma mansoni survival motor neuron protein 0.0048 0.0058 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Echinococcus multilocularis geminin 0.0342 0.0524 0.0898
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0025 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0012 0.0323
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0008 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Schistosoma mansoni DNA polymerase eta 0.0019 0.0013 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Schistosoma mansoni biogenic amine receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0011 0.0004
Brugia malayi hypothetical protein 0.0236 0.0357 0.0356
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0025 0.0029
Brugia malayi larval opioid receptor 0.0018 0.0011 0.0009
Echinococcus granulosus serotonin transporter 0.016 0.0236 0.0396
Echinococcus granulosus tm gpcr rhodopsin 0.0534 0.083 0.1429
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0016
Giardia lamblia DINP protein human, muc B family 0.0019 0.0013 1
Mycobacterium tuberculosis Probable reductase 0.011 0.0156 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.003 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0013
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0013 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0011 0.0004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0008 0.0008
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0004
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.3637 0.5755 0.5751
Brugia malayi Pre-SET motif family protein 0.0211 0.0318 0.0316
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0011 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0012 0.8146
Schistosoma mansoni hypothetical protein 0.0048 0.0058 0.0087
Schistosoma mansoni sodium/chloride dependent transporter 0.016 0.0236 0.0396
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0011 0.0004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0011 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Onchocerca volvulus 0.0027 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0013 0.0013
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0004
Plasmodium falciparum amino acid transporter, putative 0.0027 0.0025 0.3351
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Trypanosoma cruzi Emopamil binding protein, putative 0.0137 0.02 0.02
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Schistosoma mansoni opsin-like receptor 0.0018 0.0011 0.0004
Brugia malayi Abnormal catecholamine distribution protein 1 0.0191 0.0285 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.003 0.0038
Echinococcus granulosus neuropeptide receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0011 0.0002
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0011 0.0004
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.0025 0.0029
Leishmania major hypothetical protein, conserved 0.0137 0.02 0.02
Brugia malayi AKH receptor 0.0018 0.0011 0.0009
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0012 0.0012
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0011 0.0004
Brugia malayi GnHR receptor homolog 0.0018 0.0011 0.0009
Plasmodium falciparum thioredoxin reductase 0.0048 0.0058 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus granulosus neuropeptide receptor 0.0018 0.0011 0.0004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0013 0.0252
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Echinococcus granulosus dna polymerase kappa 0.0019 0.0013 0.0007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0156 0.8837
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 1
Echinococcus granulosus g protein coupled receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis dna polymerase eta 0.0019 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.0025 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0016
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0008 0.0707
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0013
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0016
Onchocerca volvulus 0.003 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 1
Loa Loa (eye worm) norepinephrine transporter 0.016 0.0236 0.0227
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0008 0.066
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0016 0.0434
Brugia malayi Serotonin receptor 0.0018 0.0011 0.0009
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0011 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0156 0.8837
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0011 0.0004
Schistosoma mansoni neuropeptide receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0003
Treponema pallidum sodium- and chloride- dependent transporter 0.016 0.0236 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0025 0.0024
Brugia malayi putative neuropeptide receptor 0.0018 0.0011 0.0009
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0011 0.0004
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0011 0.0004
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0011 0.0004
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Schistosoma mansoni hypothetical protein 0.0342 0.0524 0.0898
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0376 0.0367
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Trypanosoma brucei unspecified product 0.0013 0.0003 0.0003
Brugia malayi Pre-SET motif family protein 0.003 0.003 0.0029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0012
Trypanosoma brucei C-8 sterol isomerase, putative 0.6311 1 1
Echinococcus granulosus g protein coupled receptor 0.0018 0.0011 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.003 0.0038
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Brugia malayi Melatonin receptor type 1A 0.0018 0.0011 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0008
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0011 0.0002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0011 0.0004
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0025 0.0016
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0025 0.3821
Loa Loa (eye worm) serotonin transporter b 0.016 0.0236 0.0227
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0012 0.0669
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0534 0.083 0.1429
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0175 1
Echinococcus multilocularis sex peptide receptor 0.0018 0.0011 0.0004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0012 0.9377
Loa Loa (eye worm) solute carrier family 6 member 4 0.016 0.0236 0.0227
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0011 0.0004
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.0025 0.0029
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.02 0.02
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0011 0.0004
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0012 0.001
Trypanosoma brucei trypanothione reductase 0.0048 0.0058 0.0058
Brugia malayi neuropeptide F receptor 0.0018 0.0011 0.0009
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0011 0.0004
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0011 0.0004
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0011 0.0004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0025 0.0029
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.016 0.0236 0.0396
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0025 0.0029
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0011 0.0004
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.0025 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0241 0.0364 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0025 0.0029
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0058 1
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0008 0.0008
Loa Loa (eye worm) RecQ helicase 0.0021 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0011 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0058 0.0087
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0016 0.0014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0012 0.8146
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0058 0.0057
Toxoplasma gondii hypothetical protein 0.0027 0.0025 0.3821
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0013 0.0345
Echinococcus granulosus geminin 0.0342 0.0524 0.0898
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0025 0.0029
Echinococcus multilocularis vesicular acetylcholine transporter 0.3637 0.5755 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0175 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0008
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0004
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0011 0.0004
Schistosoma mansoni neuropeptide receptor 0.0018 0.0011 0.0004
Echinococcus granulosus synaptic vesicular amine transporter 0.0191 0.0285 0.0482
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.0688
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0011 0.0004
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.02 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Echinococcus granulosus vesicular acetylcholine transporter 0.3637 0.5755 1
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0011 0.0004
Schistosoma mansoni myosin xvIII 0.0018 0.0011 0.0004
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0011 0.0004
Schistosoma mansoni histamine h1 receptor 0.0018 0.0011 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0013 0.0345
Leishmania major DNA polymerase eta, putative 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0016
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0011 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.016 0.0236 0.0235
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0011 0.0004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0011 0.0004
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0016 0.0013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0011 0.0004
Echinococcus granulosus hypothetical protein 0.0018 0.0011 0.0004
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Brugia malayi Thioredoxin reductase 0.0048 0.0058 0.0057
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0008 0.0229
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0011 0.0004
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0011 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.003 0.0038
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0025 0.0029
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0013 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0025 0.0024
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus multilocularis serotonin receptor 0.0018 0.0011 0.0004
Brugia malayi G-protein coupled receptor 0.0018 0.0011 0.0009
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0008 0.0008
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0025 0.0029
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0011 0.0004
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0011 0.0004
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.003 0.0038
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0008
Trypanosoma brucei unspecified product 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0011 0.0004
Onchocerca volvulus 0.0027 0.0025 0.0025
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0011 0.0004
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.0025 0.0029
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Plasmodium vivax amine transporter, putative 0.0027 0.0025 0.379
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0008 0.0008
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Onchocerca volvulus 0.0027 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Schistosoma mansoni amine GPCR 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0011 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0011 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0011 0.0002
Brugia malayi Dopamine receptor protein 1 0.0018 0.0011 0.0009
Schistosoma mansoni vesicular amine transporter 0.0191 0.0285 0.0482
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.0006
Echinococcus granulosus fmrfamide receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Toxoplasma gondii exonuclease III APE 0.0019 0.0012 0.1347
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0008 0.0008
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.0025 0.0029
Schistosoma mansoni opsin-like receptor 0.0018 0.0011 0.0004
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0025 0.0029
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0016 0.0434
Echinococcus multilocularis somatostatin receptor 0.0018 0.0011 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Schistosoma mansoni hypothetical protein 0.0342 0.0524 0.0898
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0011 0.0009
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0012 0.0151
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0012 0.1303
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0007
Schistosoma mansoni adenoreceptor 0.0018 0.0011 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0058 0.0058
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0058 0.2985
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0011 0.0004
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0011 0.0009
Brugia malayi sulfakinin receptor protein 0.0018 0.0011 0.0009
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0009 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0011 0.0004
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0021
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0011 0.0004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0011 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Leishmania major C-8 sterol isomerase-like protein 0.6311 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0013
Plasmodium falciparum glutathione reductase 0.0048 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0011 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0013 0.0252
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0012 0.0012
Echinococcus granulosus allatostatin A receptor 0.0018 0.0011 0.0004
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0011 0.0009
Echinococcus granulosus dna polymerase eta 0.0019 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Schistosoma mansoni neuropeptide receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0025 0.0029
Trypanosoma brucei unspecified product 0.0019 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0004
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.3637 0.5755 1
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0011 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0011 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0011 0.0002
Brugia malayi Dopamine receptor 0.0018 0.0011 0.0009
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis synaptic vesicular amine transporter 0.0191 0.0285 0.0482
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0011 0.0004
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0013 0.0013
Brugia malayi hypothetical protein 0.0018 0.0011 0.0009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0008 0.0008
Schistosoma mansoni vesicular acetylcholine transporter 0.3637 0.5755 1
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0011 0.0004
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0011 0.0004
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0013 0.0007
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0175 1
Echinococcus granulosus somatostatin receptor 0.0018 0.0011 0.0004
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0011 0.0004
Trypanosoma cruzi Emopamil binding protein, putative 0.0137 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.016 0.0236 0.0227
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0011 0.0004
Echinococcus granulosus g protein coupled receptor 0.0018 0.0011 0.0004
Brugia malayi G-protein coupled receptor 0.0018 0.0011 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.3226 0.5102 0.5098
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0011 0.0009
Brugia malayi neuropeptide F receptor 0.0018 0.0011 0.0009
Echinococcus multilocularis serotonin transporter 0.016 0.0236 0.0396
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0025 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0008 0.0008
Brugia malayi vesicular acetylcholine transporter unc-17 0.3637 0.5755 0.5754
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0025 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0008 0.0008
Onchocerca volvulus 0.0241 0.0364 0.0615
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0025 0.3821
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0011 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.016 0.0236 0.0227
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0011 0.0004
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0236 0.0357 0.0349
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0156 0.8837
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0318 0.0309
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0002

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 81 % Compound tested for contractility in isolated cat papillary muscle at 10 e-4 M. ChEMBL. 4009593
Control (functional) = 105 % Compound tested for contractility in isolated cat papillary muscle at 10 e-5 M. ChEMBL. 4009593
ED50 (functional) 0 mg kg-1 Compound tested for contractility in anesthetized dog when administered intravenously; NT = not tested ChEMBL. 4009593
Response ratio (functional) = -0.26 Response ratio = (percent increase to drug)/(percent increase to 10 E-4 M isoproterenol) ChEMBL. 4009593
Response ratio (functional) = 0.07 Response ratio = (percent increase to drug)/(percent increase to 10 E-5 M isoproterenol) ChEMBL. 4009593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.