Detailed information for compound 279679

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.326 | Formula: C19H15NO5
  • H donors: 0 H acceptors: 1 LogP: 3.03 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CN1C2Cc3c(C1Cc1c2cc2OCOc2c1)cc1c(c3)OCO1
  • InChi: 1S/C19H15NO5/c21-7-20-14-1-10-3-16-18(24-8-22-16)5-12(10)15(20)2-11-4-17-19(6-13(11)14)25-9-23-17/h3-7,14-15H,1-2,8-9H2
  • InChiKey: AHETZBHERXKVNO-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0083 0.0328
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0083 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0036 0.0153
Brugia malayi Carboxypeptidase A2 precursor 0.001 0.0003 0.0003
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0031 0.2046
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0029 0.0029
Echinococcus granulosus neuropeptide s receptor 0.0453 0.1119 0.4467
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0021
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0029 0.0029
Onchocerca volvulus 0.0011 0.0007 0.0055
Trypanosoma cruzi kinesin, putative 0.0014 0.0015 0.0903
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0075 0.525
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.1694
Loa Loa (eye worm) hypothetical protein 0.0098 0.0225 0.0225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0091 0.0545
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0029 0.1931
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Onchocerca volvulus 0.0056 0.0119 0.1467
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0417 0.6008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0019 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0068 0.0258
Schistosoma mansoni hypothetical protein 0.0098 0.0225 0.1341
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0036 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0068 0.0953
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0068
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.4792
Echinococcus multilocularis calpain family protein 1, d 0.004 0.008 0.0482
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0026 0.0337
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0031 0.2046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0091 0.0532
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0015 0.0187
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.1119 0.6745
Brugia malayi CHD4 protein 0.0013 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0091 0.0532
Echinococcus granulosus Chromobox protein 3 0.0011 0.0007 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0213
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0068
Plasmodium vivax methionine-tRNA ligase, putative 0.0015 0.0017 0.1834
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0019 0.0017
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0003 0.001
Entamoeba histolytica tyrosyl-tRNA synthetase, putative 0.002 0.0028 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0031 0.2046
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0007 0.0063
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0291 0.0291
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.0692 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0056 0.0339
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0026 0.0275
Echinococcus multilocularis musashi 0.0026 0.0044 0.0265
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0123 0.0726
Trypanosoma cruzi kinesin, putative 0.0014 0.0015 0.0903
Entamoeba histolytica protein kinase, putative 0.0014 0.0015 0.0117
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0003 0.0002
Leishmania major tyrosyl or methionyl-tRNA synthetase-like protein 0.0015 0.0017 0.107
Echinococcus granulosus calpain A 0.0021 0.0031 0.0121
Brugia malayi chromobox protein homolog 3 0.0039 0.0076 0.0076
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.001 0.0003 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0036 0.043
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.001 0.0003 0.0014
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0208 0.1242
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0044 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.0171
Schistosoma mansoni hypothetical protein 0.0031 0.0056 0.0325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0128 0.0757
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0208 0.1242
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0057 0.0123 0.0739
Toxoplasma gondii tRNA binding domain-containing protein 0.0015 0.0017 0.0116
Echinococcus multilocularis tyrosyl tRNA synthetase 0.0035 0.0067 0.0404
Loa Loa (eye worm) beta-lactamase 0.0036 0.0068 0.0068
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0072 0.0431
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0054 0.0114 0.0675
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0953
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0003 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0692 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0029 0.0115
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.014 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.1063
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0007 0.0025
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.014 0.0139
Giardia lamblia DINP protein human, muc B family 0.002 0.0029 0.0384
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0007 0.0544
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0068 0.0407
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0068 0.0407
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0225 0.0225
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0029 0.1931
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0019 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0036 0.043
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0029 0.0094
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0022 0.0036
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0022 0.2397
Brugia malayi hypothetical protein 0.0016 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.001 0.0003 0.0002
Leishmania major kinesin, putative 0.0014 0.0015 0.0903
Toxoplasma gondii methionyl-tRNA synthetase 0.0015 0.0017 0.0116
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0117 0.0116
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0029 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0036 0.0153
Echinococcus multilocularis endothelin converting enzyme 1 0.0513 0.127 0.7655
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0189 0.0454 0.2727
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0041 0.2809
Toxoplasma gondii ABC1 family protein 0.0036 0.0068 0.0518
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0692 1
Loa Loa (eye worm) POT family protein 0.0332 0.0815 0.0815
Schistosoma mansoni cpg binding protein 0.0028 0.0049 0.028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0056 0.0339
Brugia malayi N-terminal motif family protein 0.0196 0.0472 0.0472
Loa Loa (eye worm) peptidase family M13 containing protein 0.0415 0.1024 0.1024
Echinococcus multilocularis geminin 0.0667 0.1659 1
Onchocerca volvulus 0.0036 0.0068 0.083
Schistosoma mansoni cpg binding protein 0.003 0.0053 0.0304
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0003 0.0003
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0007 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0019 0.0017
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0007 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0786
Schistosoma mansoni methionyl-tRNA synthetase 0.0015 0.0017 0.0089
Echinococcus multilocularis chromobox protein 2 0.0011 0.0007 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0225 0.0225
Toxoplasma gondii exonuclease III APE 0.0019 0.0026 0.0183
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0098 0.0225 0.1341
Giardia lamblia Tyrosyl-tRNA synthetase 0.002 0.0028 0.0376
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0031 0.2046
Mycobacterium tuberculosis Conserved protein 0.0036 0.0068 0.0407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0026 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0123 0.0726
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0015 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0026
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.0472 0.593
Echinococcus granulosus inhibitor of apoptosis protein 0.0054 0.0114 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.1063
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0612 0.8845
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0612 0.8845
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0031 0.2046
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0003 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0152 0.217
Loa Loa (eye worm) zinc metallopeptidase 4 0.0091 0.0208 0.0208
Echinococcus multilocularis calpain A 0.0057 0.0123 0.0739
Schistosoma mansoni dishevelled 0.001 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0015 0.0017 0.0151
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0041 0.2809
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Trichomonas vaginalis hypothetical protein 0.0011 0.0007 0.0063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0225 0.0225
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0068 0.0068
Echinococcus granulosus chromobox protein 2 0.0011 0.0007 0.0026
Onchocerca volvulus 0.0023 0.0036 0.0427
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0031 0.2046
Loa Loa (eye worm) hypothetical protein 0.0513 0.127 0.127
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0003 0.0001
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0003 0.0015
Echinococcus multilocularis lamin dm0 0.0026 0.0044 0.0265
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0091 0.0545
Echinococcus multilocularis Chromo domain 0.0011 0.0007 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0394 0.5683
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0786
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0044 0.0044
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0003 0.0001
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0074 1
Loa Loa (eye worm) calpain family protein 1 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0031 0.0056 0.0325
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0953
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0417 0.6008
Plasmodium vivax calpain, putative 0.0021 0.0031 0.3506
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0056 0.0224
Onchocerca volvulus 0.0056 0.0119 0.1467
Echinococcus granulosus cytosolic carboxypeptidase 1 0.001 0.0003 0.0009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.2818
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0056 0.0119 0.0701
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0007 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0692 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0295
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0612 0.8845
Schistosoma mansoni hypothetical protein 0.0031 0.0056 0.0325
Brugia malayi calpain family protein 1 0.0055 0.0117 0.0117
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0029 0.1931
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0068
Echinococcus multilocularis cpg binding protein 0.003 0.0053 0.0318
Loa Loa (eye worm) hypothetical protein 0.0422 0.104 0.104
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0023 0.0295
Schistosoma mansoni neprilysin-2 (M13 family) 0.0189 0.0454 0.2727
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0026 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Onchocerca volvulus 0.0056 0.0119 0.1467
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0003 0.0003
Loa Loa (eye worm) acetyltransferase 0.014 0.0332 0.0332
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0068 0.0396
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0054 0.0114 0.0456
Trypanosoma brucei tyrosyl-tRNA synthetase, putative 0.0015 0.0017 0.107
Onchocerca volvulus 0.0034 0.0065 0.0783
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0031 0.2046
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0054 0.0114 0.0114
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0083 0.117
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0029 0.1931
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0041 0.5101
Brugia malayi DIX domain containing protein 0.001 0.0003 0.0003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0692 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0031 0.2046
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0003 0.0003
Schistosoma mansoni chromobox protein 0.0011 0.0007 0.0026
Brugia malayi hypothetical protein 0.0025 0.0041 0.0041
Brugia malayi beta-lactamase family protein 0.0036 0.0068 0.0068
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0003 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.1119 0.4467
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0208 0.1242
Onchocerca volvulus 0.0036 0.0068 0.083
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0007 0.0007
Onchocerca volvulus 0.0056 0.0119 0.1467
Onchocerca volvulus 0.001 0.0003 0.0003
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0022 0.2213
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0068 0.0396
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0007 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0295
Brugia malayi CXXC zinc finger family protein 0.0028 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0054 0.0114 0.0114
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0007 0.0026
Toxoplasma gondii tRNA synthetases class I family protein 0.002 0.0028 0.0205
Toxoplasma gondii peptidase family M13 protein 0.0513 0.127 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Echinococcus granulosus calpain A 0.0057 0.0123 0.0489
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0031 0.0169
Echinococcus multilocularis calpain 0.0021 0.0031 0.0183
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0102
Leishmania major DNA polymerase kappa, putative 0.002 0.0029 0.1931
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0068 0.0407
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0031 0.0183
Onchocerca volvulus 0.0026 0.0044 0.0528
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0014 0.0014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0026 0.0068
Schistosoma mansoni hypothetical protein 0.0098 0.0225 0.1341
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0074 0.1034
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0036 0.0036
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.2904
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.014 1
Leishmania major DNA polymerase eta, putative 0.002 0.0029 0.1931
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0007 0.0026
Echinococcus multilocularis lamin 0.0026 0.0044 0.0265
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0026 0.1694
Schistosoma mansoni hypothetical protein 0.0054 0.0114 0.0675
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0101 0.0101
Schistosoma mansoni regulator of G protein signaling 0.001 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0415 0.1024 0.1024
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0003 0.0015
Leishmania major tyrosyl-tRNA synthetase, putative 0.002 0.0028 0.1893
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0031 0.2046
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0029 0.016
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0036 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0029 0.1931
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0098 0.0225 0.1341
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0036 0.2466
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0041 0.0304
Schistosoma mansoni dishevelled 0.001 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0415 0.1024 0.1024
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.002 0.0028 0.0376
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0054 0.0114 0.0688
Schistosoma mansoni inhibitor of apoptosis protein 0.0054 0.0114 0.0675
Leishmania major hypothetical protein 0.0015 0.0017 0.107
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0076
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0056 0.0056
Echinococcus multilocularis chromobox protein 1 0.0069 0.0152 0.0915
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0029 0.0323
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0007 0.0034
Echinococcus granulosus calpain 5 0.0021 0.0031 0.0121
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0091 0.0091
Brugia malayi Protein cec-1. 0.0011 0.0007 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0036 0.2466
Brugia malayi hypothetical protein 0.0011 0.0007 0.0007
Echinococcus granulosus dna polymerase eta 0.002 0.0029 0.0115
Echinococcus granulosus GPCR family 2 0.0031 0.0056 0.0224
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0021
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0026
Trichomonas vaginalis esterase, putative 0.0036 0.0068 0.0953
Leishmania major hypothetical protein, conserved 0.0038 0.0075 0.525
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0036 0.0153
Loa Loa (eye worm) hypothetical protein 0.0054 0.0114 0.0114
Trypanosoma cruzi tyrosyl-tRNA synthetase, putative 0.002 0.0028 0.1893
Brugia malayi methionyl-tRNA synthetase 0.0015 0.0017 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0337
Mycobacterium ulcerans hypothetical protein 0.0036 0.0068 0.0407
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0031 0.0121
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.014
Brugia malayi calpain 5 0.0014 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0063
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0031 0.2046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0029 0.016
Plasmodium falciparum tyrosine--tRNA ligase 0.002 0.0028 0.3224
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0044 0.0044
Schistosoma mansoni intermediate filament proteins 0.0026 0.0044 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0068 0.8212
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0041 0.2809
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0327 0.2473
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0213
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0068 0.0068
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.0612 0.0612
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0022 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0394 0.5683
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.0612 0.0612
Brugia malayi POT family protein 0.0332 0.0815 0.0815
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.014 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0029 0.1931
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0017 0.107
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0055
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.014 1
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0152 0.217
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0068 0.041
Loa Loa (eye worm) hypothetical protein 0.0324 0.0794 0.0794
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0007 0.0544
Brugia malayi peptidase family M13 containing protein 0.0091 0.0208 0.0208
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0007 0.0007
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.014 0.1937
Trypanosoma cruzi tyrosyl or methionyl-tRNA synthetase, putative 0.0015 0.0017 0.107
Echinococcus granulosus lamin dm0 0.0026 0.0044 0.0176
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0083 0.116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0692 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0068 0.0407
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0068 0.0271
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0057 0.0123 0.0489
Echinococcus multilocularis dna polymerase kappa 0.002 0.0029 0.0173
Schistosoma mansoni endothelin-converting enzyme-related 0.0091 0.0208 0.1242
Onchocerca volvulus 0.0324 0.0794 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0036 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0295
Loa Loa (eye worm) hypothetical protein 0.0513 0.127 0.127
Echinococcus granulosus endothelin converting enzyme 1 0.0513 0.127 0.5069
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.0098 0.0225 0.1341
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0063
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0332 0.0332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0091 0.0361
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0692 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0394 0.5683
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0041 0.5101
Brugia malayi calpain family protein 1 0.0055 0.0117 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.4792
Onchocerca volvulus 0.0036 0.0068 0.083
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0189 0.0454 0.2727
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0068 0.0407
Onchocerca volvulus Deterin homolog 0.0054 0.0114 0.1413
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0031 0.2046
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0083 0.117
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0008 0.0036
Echinococcus granulosus chromobox protein 1 0.0069 0.0152 0.0606
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0068 0.0407
Mycobacterium ulcerans zinc metalloprotease 0.0513 0.127 1
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0007 0.0063
Schistosoma mansoni hypothetical protein 0.0031 0.0056 0.0325
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0036 0.0153
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0422 0.104 0.104
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0786
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.014 0.014
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0022 0.0036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0036 0.0068 0.0407
Mycobacterium ulcerans lipase LipD 0.0036 0.0068 0.0407
Echinococcus granulosus cpg binding protein 0.003 0.0053 0.021
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0076 0.0926
Giardia lamblia Methionyl-tRNA synthetase 0.0015 0.0017 0.0213
Onchocerca volvulus 0.0028 0.0049 0.0586
Schistosoma mansoni chromobox protein 0.0069 0.0152 0.0903
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0187
Loa Loa (eye worm) hypothetical protein 0.0422 0.104 0.104
Echinococcus granulosus Zinc carboxypeptidase family protein 0.001 0.0003 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0029 0.1931
Mycobacterium leprae Probable lipase LipE 0.0036 0.0068 0.0258
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0029 0.0384
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0056 0.0119 0.1467
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0039 0.0219
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.3978 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0083 0.0631
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0394 0.5683
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0017 0.107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0692 1
Trypanosoma brucei antigen, putative 0.0021 0.0031 0.2046
Brugia malayi hypothetical protein 0.001 0.0003 0.0003
Echinococcus granulosus Chromo domain 0.0011 0.0007 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0029 0.1931
Schistosoma mansoni dep domain containing protein 0.001 0.0003 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0029 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0189 0.0454 0.2727
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.014 0.084
Schistosoma mansoni hypothetical protein 0.0098 0.0225 0.1341
Brugia malayi Heterochromatin protein 1 0.0069 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0098 0.0225 0.1341
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0036 0.0153
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0007 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0692 1
Loa Loa (eye worm) hypothetical protein 0.0415 0.1024 0.1024
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0213
Echinococcus multilocularis 0.001 0.0003 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0068 0.4792
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0015 0.0017 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0029 0.1931
Schistosoma mansoni chromobox protein 0.0011 0.0007 0.0026
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0029 0.0173
Echinococcus multilocularis dna polymerase eta 0.002 0.0029 0.0173
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0049 0.0049
Schistosoma mansoni cpg binding protein 0.003 0.0053 0.0304
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0031 0.2046
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0031 0.2046
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0063
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0007 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0063
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0011 0.0064
Echinococcus granulosus intermediate filament protein 0.0026 0.0044 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0068 0.0953
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0011 0.0051
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0072 0.0285
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0007 0.0544
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0091 0.0208 0.1242
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0007 0.0063
Schistosoma mansoni hypothetical protein 0.0067 0.0147 0.0872
Schistosoma mansoni calpain (C02 family) 0.0021 0.0031 0.0169
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0031 0.2046
Mycobacterium ulcerans hypothetical protein 0.0023 0.0036 0.0153
Brugia malayi intermediate filament protein 0.0026 0.0044 0.0044
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0003 0.001
Entamoeba histolytica hypothetical protein 0.0015 0.0017 0.0151
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0056 0.0056
Schistosoma mansoni chromobox protein 0.0069 0.0152 0.0903
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0513 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0692 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0513 0.127 0.127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0295
Echinococcus granulosus dna polymerase kappa 0.002 0.0029 0.0115
Mycobacterium leprae probable zinc metalloprotease 0.0513 0.127 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0068 0.0407
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0068 0.0407
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0083 0.1019
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0031 0.2046
Brugia malayi SET domain containing protein 0.0012 0.0008 0.0008
Schistosoma mansoni lamin 0.0026 0.0044 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Onchocerca volvulus 0.003 0.0055 0.066
Schistosoma mansoni tyrosyl-tRNA synthetase 0.0035 0.0067 0.039
Echinococcus granulosus Solute carrier family 22 5 0.1003 0.2505 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0031 0.2046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0692 1
Echinococcus multilocularis aminoacyl tRNA synthase complex interacting 0.0015 0.0017 0.0102
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0029 0.0029
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0003 0.0002
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0394 0.4949
Plasmodium falciparum tRNA import protein tRIP 0.0015 0.0017 0.154
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0074 0.0977
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0036 0.0036
Mycobacterium tuberculosis Conserved protein 0.0036 0.0068 0.0407
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0121 0.0932
Brugia malayi MH2 domain containing protein 0.0124 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0021
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0029 0.1931
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0068 0.0407
Echinococcus multilocularis inhibitor of apoptosis protein 0.0054 0.0114 0.0688
Trypanosoma brucei unspecified product 0.002 0.0029 0.1931
Loa Loa (eye worm) hypothetical protein 0.0415 0.1024 0.1024
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0007 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0056 0.0056
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0031 0.2046
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0612 0.8845
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0154
Echinococcus granulosus aminoacyl tRNA synthase complex interacting 0.0015 0.0017 0.0068
Loa Loa (eye worm) hypothetical protein 0.0422 0.104 0.104
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0394 0.5683
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0047 0.0651
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0003 0.0015
Schistosoma mansoni lamin 0.0026 0.0044 0.0252
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0786
Plasmodium vivax tyrosine--tRNA ligase, putative 0.002 0.0028 0.3244
Loa Loa (eye worm) hypothetical protein 0.0055 0.0117 0.0116
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0003 0.001
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.001 0.0003 0.0014
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0007 0.0038
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0007 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0213
Trypanosoma brucei kinesin, putative 0.0014 0.0015 0.0903
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0068 0.0407
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0513 0.127 0.7652
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0031 0.2046
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0031 0.2046
Leishmania major hypothetical protein, conserved 0.0025 0.0041 0.2809
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0063
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0552 0.4267
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0031 0.0169
Trypanosoma cruzi tyrosyl or methionyl-tRNA synthetase, putative 0.0015 0.0017 0.107
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Onchocerca volvulus 0.0026 0.0044 0.0528
Schistosoma mansoni neprilysin 0.0098 0.0225 0.1341
Echinococcus multilocularis chromobox protein 1 0.0069 0.0152 0.0915
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0047 0.0651
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.1119 0.6745
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0295
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0189 0.0454 0.2727
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.0422 0.104 0.104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.0063
Trichomonas vaginalis methionyl-tRNA synthetase, putative 0.0015 0.0017 0.0213
Loa Loa (eye worm) peptidase family M13 containing protein 0.0415 0.1024 0.1024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0026 0.1694
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0029 0.0384
Echinococcus granulosus chromobox protein 1 0.0069 0.0152 0.0606
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0036 0.2466
Brugia malayi calpain 7 0.0021 0.0031 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0612 0.8845
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0025
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.014 0.0827
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0667 0.1659 1
Trypanosoma brucei tyrosyl/methionyl-tRNA synthetase, putative 0.0015 0.0017 0.107
Echinococcus granulosus geminin 0.0667 0.1659 0.6622
Leishmania major hypothetical protein, conserved 0.0036 0.0068 0.4792
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0023 0.0295
Loa Loa (eye worm) calpain 5 0.0014 0.0015 0.0015
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0036 0.0153
Loa Loa (eye worm) hypothetical protein 0.0054 0.0114 0.0114
Entamoeba histolytica calpain large subunit domain III containing protein 0.0014 0.0015 0.0117
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0029 0.0094
Loa Loa (eye worm) hypothetical protein 0.0046 0.0095 0.0094
Onchocerca volvulus 0.0012 0.0008 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0029 0.1931
Loa Loa (eye worm) calpain 0.0021 0.0031 0.003
Loa Loa (eye worm) helicase 0.0011 0.0007 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0023 0.0295
Onchocerca volvulus 0.0011 0.0007 0.0055
Schistosoma mansoni hypothetical protein 0.0051 0.0107 0.0633
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0612 0.8845
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0056 0.0119 0.0714
Loa Loa (eye worm) hypothetical protein 0.0196 0.0472 0.0472
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.0063
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.001 0.006
Brugia malayi Peptidase family M13 containing protein 0.0513 0.127 0.127
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0056 0.0119 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0786
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.014
Schistosoma mansoni DNA polymerase eta 0.002 0.0029 0.016
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0003 0.001
Brugia malayi beta-lactamase family protein 0.0036 0.0068 0.0068
Trypanosoma brucei tyrosyl-tRNA synthetase, putative 0.002 0.0028 0.1893
Leishmania major hypothetical protein, conserved 0.0015 0.0017 0.107
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0056
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.1694
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0332 0.2001
Schistosoma mansoni hypothetical protein 0.0667 0.1659 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.014 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0003 0.0003
Schistosoma mansoni calpain-7 (C02 family) 0.0024 0.0039 0.0219
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0152 0.0152
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0036 0.0153
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0007 0.0063
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0003 0.0002
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0091 0.0208 0.1242
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0056 0.0224
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0003 0.0015
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0332 0.199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0091 0.0361
Echinococcus granulosus lamin 0.0026 0.0044 0.0176
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0083 0.116
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0083 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.0063
Onchocerca volvulus 0.0054 0.0114 0.1413
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0068
Brugia malayi beta-lactamase 0.0036 0.0068 0.0068
Brugia malayi hypothetical protein 0.001 0.0003 0.0003
Echinococcus multilocularis hypothetical protein 0.0021 0.0031 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0075 0.525
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0036 0.0153
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0147 0.0147
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0327 0.2473
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.0692 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0026 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0091 0.0532
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0322 0.1286
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0117 0.0689
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0041 0.4815
Loa Loa (eye worm) hypothetical protein 0.0067 0.0147 0.0147
Echinococcus granulosus tyrosyl tRNA synthetase 0.0035 0.0067 0.0267
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0394 0.5683
Echinococcus granulosus calpain 0.0021 0.0031 0.0121
Echinococcus multilocularis calpain 5 0.0021 0.0031 0.0183
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0513 0.127 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0056 0.0339
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0327 0.2356
Loa Loa (eye worm) hypothetical protein 0.0422 0.104 0.104
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0394 0.5683

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 22 uM In vitro inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS ChEMBL. No reference
IC50 (functional) = 22 uM In vitro inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS ChEMBL. No reference
Survival rate (functional) = 0 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 0 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 0 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 0 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 7 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 50 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 7 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 100 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 7 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 50 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 7 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 100 mg/kg on day 7 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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