Detailed information for compound 287358

Basic information

Technical information
  • TDR Targets ID: 287358
  • Name: 2-chloro-6-iodo-1H-benzimidazol-5-amine
  • MW: 293.492 | Formula: C7H5ClIN3
  • H donors: 2 H acceptors: 1 LogP: 2.42 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1[nH]c2c(n1)cc(c(c2)N)I
  • InChi: 1S/C7H5ClIN3/c8-7-11-5-1-3(9)4(10)2-6(5)12-7/h1-2H,10H2,(H,11,12)
  • InChiKey: SGLZOBHYWCZASX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-chloro-6-iodo-1H-benzimidazol-5-yl)amine
  • 6(5)-Amino-2-chloro-5(6)-iodobenzimidazole
  • AIDS-059793
  • AIDS059793

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0026 0.0016 0.0084
Echinococcus granulosus histone deacetylase 6 0.0417 0.0918 0.0918
Schistosoma mansoni serine/threonine protein kinase 0.0019 0 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0016 0.0084
Brugia malayi intermediate filament protein 0.0026 0.0018 0.0027
Plasmodium vivax glutathione reductase, putative 0.0046 0.0063 0.0121
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0002 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0016 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Toxoplasma gondii aspartyl protease ASP1 0.0048 0.0068 0.0131
Brugia malayi Matrixin family protein 0.1191 0.2698 0.405
Brugia malayi ADAMTS-like protease 0.0089 0.0163 0.0244
Plasmodium vivax histone deacetylase, putative 0.0417 0.0918 0.1755
Loa Loa (eye worm) glutathione reductase 0.0046 0.0063 0.0095
Echinococcus multilocularis histone deacetylase 7 0.0417 0.0918 0.0918
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0356 0.0777 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0175 0.036 0.0561
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0027
Leishmania major cathepsin L-like protease 0.0026 0.0016 0.0084
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0103 0.0194 0.0237
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0063 0.0063
Loa Loa (eye worm) dihydrofolate reductase 0.0049 0.0071 0.0107
Plasmodium vivax peptide deformylase, putative 0.2292 0.523 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0139 0.0277 0.0784
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0002 0.0025
Echinococcus granulosus endothelin converting enzyme 1 0.0276 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0208 0.0437 0.0656
Brugia malayi histone deacetylase 11 0.0348 0.0759 0.1139
Loa Loa (eye worm) hypothetical protein 0.0204 0.0426 0.064
Schistosoma mansoni histone deacetylase hda2 0.0175 0.036 0.1018
Onchocerca volvulus 0.023 0.0488 0.076
Leishmania major trypanothione reductase 0.0046 0.0063 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0019 0 0.0006
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0121 0.0237 0.0321
Loa Loa (eye worm) RGS-3 protein 0.0019 0 0.0001
Leishmania major cysteine peptidase A (CPA) 0.0026 0.0016 0.0084
Trypanosoma cruzi histone deacetylase, putative 0.0175 0.036 0.1829
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0021
Schistosoma mansoni neprilysin 0.0072 0.0123 0.0348
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0072 0.0123 0.0348
Schistosoma mansoni histone deacetylase 0.0356 0.0777 0.2197
Trypanosoma brucei Peptide deformylase 2 0.0874 0.1969 1
Schistosoma mansoni hypothetical protein 0.0072 0.0123 0.0348
Echinococcus multilocularis aminopeptidase N 0.0115 0.0223 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Loa Loa (eye worm) hypothetical protein 0.0208 0.0437 0.0656
Leishmania major histone deacetylase, putative 0.0356 0.0777 0.3948
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0199 0.0262
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0567 0.1263 0.357
Schistosoma mansoni histone deacetylase 1 2 3 0.0175 0.036 0.1018
Brugia malayi Matrixin family protein 0.2914 0.6662 1
Onchocerca volvulus Matrilysin homolog 0.2808 0.6419 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0016 0.0025
Trypanosoma cruzi Peptide deformylase 2, putative 0.0874 0.1969 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0 0.0006
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0005 0.0005
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0275 0.0589 0.0589
Echinococcus multilocularis histone deacetylase 6 0.0417 0.0918 0.0918
Brugia malayi Cathepsin L-like precursor 0.0026 0.0016 0.0025
Loa Loa (eye worm) RecQ helicase 0.0019 0.0002 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0024 0.0069
Plasmodium vivax vivapain-2 0.0026 0.0016 0.0032
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0002 0.0003
Onchocerca volvulus 0.0026 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0208 0.0437 0.0656
Onchocerca volvulus 0.0121 0.0237 0.0369
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0171 0.0351 0.1781
Echinococcus granulosus histone deacetylase 7 0.0417 0.0918 0.0918
Schistosoma mansoni DNA helicase recq5 0.0019 0.0002 0.0005
Entamoeba histolytica histone deacetylase, putative 0.0356 0.0777 1
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0276 0.0592 0.1022
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0777 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Echinococcus granulosus histone deacetylase 1 0.0356 0.0777 0.0777
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0 0.0001
Schistosoma mansoni hypothetical protein 0.0035 0.0038 0.0108
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0005 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0014 0.0027
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0049 0.0071 0.0016
Loa Loa (eye worm) zinc metallopeptidase 4 0.0067 0.0112 0.0168
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0016 0.0026
Echinococcus granulosus aminopeptidase N 0.0115 0.0223 0.0223
Entamoeba histolytica hypothetical protein 0.0019 0 0.0006
Onchocerca volvulus 0.0026 0.0016 0.0026
Mycobacterium leprae probable zinc metalloprotease 0.0276 0.0592 0.1008
Brugia malayi Pax transcription factor protein 2 0.0234 0.0496 0.0745
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0048 0.0068 0.0103
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0036 0.0054
Leishmania major cathepsin L-like protease 0.0026 0.0016 0.0084
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0209 0.0438 0.1238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Loa Loa (eye worm) hypothetical protein 0.0242 0.0515 0.0773
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0018 0.0027
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0777 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0103 0.0194 0.0984
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0103 0.0194 0.037
Plasmodium falciparum glutathione reductase 0.0046 0.0063 0.0121
Plasmodium vivax aspartyl proteinase, putative 0.0048 0.0068 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.009 0.1163
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.002 0.0005 0.0007
Brugia malayi Peptidase family M13 containing protein 0.0276 0.0592 0.0888
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0072 0.0123 0.0348
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0058 0.009 0.0459
Toxoplasma gondii histone deacetylase HDAC3 0.0356 0.0777 0.1487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Brugia malayi peptidase family M13 containing protein 0.0067 0.0112 0.0168
Trypanosoma brucei Polypeptide deformylase 1 0.0874 0.1969 1
Echinococcus granulosus dihydrofolate reductase 0.0049 0.0071 0.0071
Entamoeba histolytica cysteine protease, putative 0.0026 0.0016 0.0212
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0204 0.0426 0.064
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0276 0.0592 0.1672
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0069 0.0104
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0016 0.0032
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0874 0.1969 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.002 0.0005 0.0023
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0002 0.0003
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0003
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.002 0.0005 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Trypanosoma cruzi histone deacetylase, putative 0.0417 0.0918 0.466
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0226 0.0315
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0016 0.0032
Echinococcus granulosus leucyl aminopeptidase 0.002 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.1557 0.3539 1
Brugia malayi Histone deacetylase family protein 0.0417 0.0918 0.1377
Onchocerca volvulus 0.0026 0.0016 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0262 0.074
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0014 0.0071
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0048 0.0068 0.0068
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0239 0.0239
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0002 0.001
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0356 0.0777 1
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0016 0.0212
Echinococcus multilocularis lamin dm0 0.0026 0.0018 0.0018
Echinococcus granulosus adam 17 protease 0.1322 0.2998 0.2998
Schistosoma mansoni intermediate filament proteins 0.0026 0.0018 0.0051
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0067 0.0112 0.0316
Schistosoma mansoni hypothetical protein 0.0072 0.0123 0.0348
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.1772 0.1772
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0036 0.0458
Loa Loa (eye worm) histone deacetylase 0.0417 0.0918 0.1377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0024 0.0069
Trypanosoma brucei histone deacetylase 4 0.0417 0.0918 0.466
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0567 0.1263 0.1263
Loa Loa (eye worm) hypothetical protein 0.0261 0.0558 0.0837
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0005 0.0023
Plasmodium falciparum M17 leucyl aminopeptidase 0.0103 0.0194 0.037
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.1202 0.2722 0.7693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Chlamydia trachomatis cytosol aminopeptidase 0.0103 0.0194 0.0237
Plasmodium falciparum thioredoxin reductase 0.0046 0.0063 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Loa Loa (eye worm) thymidylate synthase 0.0121 0.0237 0.0355
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0016 0.0016
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.002 0.0005 0.0005
Brugia malayi PXA domain containing protein 0.0019 0 0.0001
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0 0.0006
Plasmodium falciparum histone deacetylase 1 0.0356 0.0777 0.1487
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0069 0.0104
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0199 0.0262
Schistosoma mansoni cathepsin D (A01 family) 0.0142 0.0284 0.0804
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.012 0.0233 0.0659
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0025
Brugia malayi angiogenesis inhibito 0.0089 0.0163 0.0244
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0226 0.0299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0103 0.0194 0.0984
Echinococcus multilocularis histone deacetylase 6 0.0436 0.096 0.096
Echinococcus multilocularis histone deacetylase 0.0417 0.0918 0.0918
Entamoeba histolytica hypothetical protein 0.0035 0.0038 0.049
Onchocerca volvulus Matrilysin homolog 0.1191 0.2698 0.4203
Leishmania major cathepsin L-like protease 0.0026 0.0016 0.0084
Toxoplasma gondii histone deacetylase HDAC5 0.0175 0.036 0.0689
Loa Loa (eye worm) hypothetical protein 0.0103 0.0195 0.0293
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0014 0.0027
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0016 0.0026
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0002 0.0002
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0036 0.0181
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0063 0.0063
Echinococcus multilocularis lamin 0.0026 0.0018 0.0018
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0048 0.0068 0.0068
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0081 0.0145 0.0217
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0002 0.0004
Entamoeba histolytica hypothetical protein 0.0035 0.0038 0.049
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0777 1
Brugia malayi histone deacetylase 3 (HD3) 0.0356 0.0777 0.1167
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0002 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Brugia malayi Histone deacetylase family protein 0.0417 0.0918 0.1377
Echinococcus granulosus histone deacetylase 0.0417 0.0918 0.0918
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0777 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0356 0.0777 0.1167
Loa Loa (eye worm) matrixin family protein 0.2914 0.6662 1
Echinococcus multilocularis cysteine protease 0.0026 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0208 0.0437 0.0656
Trypanosoma brucei histone deacetylase 1 0.0356 0.0777 0.3948
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0067 0.0112 0.0316
Brugia malayi Cathepsin L-like precursor 0.0026 0.0016 0.0025
Brugia malayi glutathione reductase 0.0046 0.0063 0.0095
Leishmania major histone deacetylase, putative 0.0356 0.0777 0.3948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Giardia lamblia Histone deacetylase 0.0356 0.0777 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0068 0.0193
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0002 0.0004
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0275 0.0589 0.0589
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0063 0.0095
Onchocerca volvulus 0.1557 0.3539 0.5513
Echinococcus granulosus subfamily M12B unassigned peptidase 0.012 0.0233 0.0233
Echinococcus granulosus bloom syndrome protein 0.0019 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Leishmania major cathepsin L-like protease 0.0026 0.0016 0.0084
Brugia malayi Cathepsin L-like precursor 0.0026 0.0016 0.0025
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0025
Schistosoma mansoni z-protein (S1r protein) 0.0019 0 0.0001
Brugia malayi Peptidase family M1 containing protein 0.0115 0.0223 0.0335
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0139 0.0277 0.0784
Plasmodium vivax plasmepsin IV, putative 0.0048 0.0068 0.0131
Echinococcus multilocularis disintegrin and metalloproteinase 0.012 0.0233 0.0233
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0018 0.0027
Trypanosoma brucei histone deacetylase 2 0.0175 0.036 0.1829
Schistosoma mansoni neprilysin-2 (M13 family) 0.0139 0.0277 0.0784
Loa Loa (eye worm) ctsf protein 0.0026 0.0016 0.0025
Loa Loa (eye worm) histone deacetylase 1 0.0356 0.0777 0.1167
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.002 0.0005 0.0007
Plasmodium vivax histone deacetylase, putative 0.0348 0.0759 0.1451
Echinococcus granulosus lamin 0.0026 0.0018 0.0018
Loa Loa (eye worm) histone deacetylase 3 0.0356 0.0777 0.1167
Echinococcus granulosus adam 0.0209 0.0438 0.0438
Onchocerca volvulus 0.0026 0.0016 0.0026
Echinococcus multilocularis histone deacetylase 3 0.0356 0.0777 0.0777
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0012
Leishmania major hypothetical protein, conserved 0.0025 0.0014 0.0071
Mycobacterium ulcerans peptide deformylase 0.2292 0.523 1
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0016 0.0084
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0049 0.0071 0.0069
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0226 0.0315
Loa Loa (eye worm) matrixin family protein 0.2642 0.6036 0.9059
Schistosoma mansoni regulator of G protein signaling 0.0019 0 0.0001
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0103 0.0194 0.0984
Trypanosoma cruzi histone deacetylase 1, putative 0.0356 0.0777 0.3948
Echinococcus multilocularis dihydrofolate reductase 0.0049 0.0071 0.0071
Onchocerca volvulus 0.0234 0.0496 0.0773
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Onchocerca volvulus 0.0026 0.0016 0.0026
Toxoplasma gondii peptidase family M13 protein 0.0276 0.0592 0.1131
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0036 0.0054
Loa Loa (eye worm) hypothetical protein 0.0276 0.0592 0.0888
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0016 0.0032
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0199 0.0262
Loa Loa (eye worm) hypothetical protein 0.0033 0.0034 0.0051
Mycobacterium leprae PROBABLE HYDROLASE 0.1451 0.3295 0.625
Schistosoma mansoni axis inhibition protein axin 0.0019 0 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0175 0.036 0.0541
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0034 0.0051
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0171 0.0351 0.1781
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0199 0.0262
Mycobacterium tuberculosis Probable reductase 0.0105 0.0199 0.0262
Trypanosoma brucei histone deacetylase 3 0.0417 0.0918 0.466
Brugia malayi Pre-SET motif family protein 0.0029 0.0024 0.0037
Brugia malayi Matrixin family protein 0.1191 0.2698 0.405
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0262 0.074
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0423 0.0635
Schistosoma mansoni lamin 0.0026 0.0018 0.0051
Onchocerca volvulus 0.0026 0.0018 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0019 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0067 0.0112 0.0316
Echinococcus multilocularis geminin 0.0165 0.0337 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0016 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Brugia malayi hypothetical protein 0.0019 0 0.0001
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.4365 1 1
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0016 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Brugia malayi hypothetical protein 0.0058 0.009 0.0136
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0204 0.0426 0.064
Echinococcus multilocularis leucine aminopeptidase protein 0.0103 0.0194 0.0194
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0 0.0001
Loa Loa (eye worm) reprolysin 0.012 0.0233 0.035
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0754 0.1692 0.1692
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Plasmodium falciparum plasmepsin II 0.0048 0.0068 0.0131
Brugia malayi hypothetical protein 0.0025 0.0014 0.0021
Trypanosoma brucei aminopeptidase, putative 0.002 0.0005 0.0023
Loa Loa (eye worm) peptidase family M1 containing protein 0.0093 0.0172 0.0258
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0048 0.0068 0.0131
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0226 0.0315
Schistosoma mansoni regulator of G protein signaling 0.0019 0 0.0001
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0 0.0001
Brugia malayi histone deacetylase 1 (HD1) 0.0356 0.0777 0.1167
Brugia malayi Dihydrofolate reductase 0.0049 0.0071 0.0107
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0276 0.0592 0.0888
Schistosoma mansoni leucine aminopeptidase 0.002 0.0005 0.0013
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0036 0.0181
Brugia malayi Thioredoxin reductase 0.0046 0.0063 0.0095
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Plasmodium falciparum plasmepsin VI 0.0048 0.0068 0.0131
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0024 0.0024
Schistosoma mansoni dihydroceramide desaturase 0.012 0.0233 0.0659
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0171 0.0351 0.0671
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Onchocerca volvulus 0.1191 0.2698 0.4203
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.002 0.0005 0.0023
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0005 0.0023
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0016 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Plasmodium vivax histone deacetylase 2, putative 0.0417 0.0918 0.1755
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0002 0.0004
Toxoplasma gondii cathepsin CPL 0.0026 0.0016 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0024 0.0069
Schistosoma mansoni hypothetical protein 0.0072 0.0123 0.0348
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0016 0.0016
Brugia malayi hypothetical protein 0.0034 0.0036 0.0054
Loa Loa (eye worm) matrix metalloproteinase 0.1191 0.2698 0.405
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0016 0.0016
Echinococcus granulosus geminin 0.0165 0.0337 0.0337
Onchocerca volvulus 0.0115 0.0223 0.0347
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0777 1
Schistosoma mansoni hypothetical protein 0.0165 0.0337 0.0952
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0014 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0262 0.0262
Echinococcus granulosus histone deacetylase 8 0.0175 0.036 0.036
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0063 0.0121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0069 0.0104
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0035 0.0038 0.049
Echinococcus multilocularis adam 0.0209 0.0438 0.0438
Onchocerca volvulus 0.0026 0.0016 0.0026
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0754 0.1692 0.1692
Loa Loa (eye worm) hypothetical protein 0.0048 0.0069 0.0104
Echinococcus granulosus histone deacetylase 6 0.0436 0.096 0.096
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0036 0.0181
Entamoeba histolytica hypothetical protein 0.0019 0 0.0006
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0067 0.0112 0.0316
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0005 0.0023
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0276 0.0592 0.0888
Onchocerca volvulus 0.0034 0.0036 0.0056
Loa Loa (eye worm) hypothetical protein 0.1191 0.2698 0.405
Loa Loa (eye worm) hypothetical protein 0.0089 0.0163 0.0244
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0038 0.0108
Toxoplasma gondii hypothetical protein 0.2292 0.523 1
Trypanosoma brucei histone deacetylase, putative 0.0417 0.0918 0.466
Trypanosoma cruzi Peptide deformylase 2, putative 0.0874 0.1969 1
Echinococcus granulosus leucine aminopeptidase protein 0.0103 0.0194 0.0194
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0567 0.1263 0.1896
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0 0.0001
Onchocerca volvulus 0.0137 0.0272 0.0423
Trichomonas vaginalis histone deacetylase, putative 0.0356 0.0777 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0121 0.0237 0.0669
Leishmania major histone deacetylase, putative 0.0417 0.0918 0.466
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0103 0.0194 0.0252
Loa Loa (eye worm) peptidase family M13 containing protein 0.0204 0.0426 0.064
Echinococcus multilocularis expressed protein 0.0363 0.0793 0.0793
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.002 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.1191 0.2698 0.405
Leishmania major cathepsin L-like protease 0.0026 0.0016 0.0084
Brugia malayi ADAM-TS Spacer 1 family protein 0.0089 0.0163 0.0244
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0016 0.0016
Schistosoma mansoni axis inhibition protein axin 0.0019 0 0.0001
Brugia malayi hypothetical protein 0.0209 0.0438 0.0658
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0016 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0038 0.0038
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0139 0.0277 0.0784
Brugia malayi cytosol aminopeptidase 0.002 0.0005 0.0007
Brugia malayi Disintegrin family protein 0.012 0.0233 0.035
Schistosoma mansoni cathepsin D (A01 family) 0.0142 0.0284 0.0804
Brugia malayi Cathepsin L-like precursor 0.0026 0.0016 0.0025
Plasmodium falciparum histone deacetylase 2 0.0417 0.0918 0.1755
Trichomonas vaginalis conserved hypothetical protein 0.0019 0 0.0006
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0139 0.0277 0.0784
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0103 0.0194 0.0984
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0171 0.0351 0.0671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Loa Loa (eye worm) fibroinase 0.0026 0.0016 0.0025
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0036 0.0181
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.002 0.0005 0.0023
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0171 0.0351 0.1781
Brugia malayi Pre-SET motif family protein 0.0202 0.0423 0.0635
Echinococcus multilocularis endothelin converting enzyme 1 0.0276 0.0592 0.0592
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0063 0.0322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.012 0.0233 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Loa Loa (eye worm) hypothetical protein 0.0208 0.0437 0.0656
Loa Loa (eye worm) hypothetical protein 0.0089 0.0163 0.0244
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0018 0.0027
Plasmodium vivax vivapain-2 0.0026 0.0016 0.0032
Trypanosoma cruzi histone deacetylase, putative 0.0417 0.0918 0.466
Toxoplasma gondii histone deacetylase HDAC2 0.0356 0.0777 0.1487
Mycobacterium ulcerans zinc metalloprotease 0.0276 0.0592 0.107
Loa Loa (eye worm) histone deacetylase 11 0.0348 0.0759 0.1139
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0024 0.0047
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0002 0.0025
Schistosoma mansoni hypothetical protein 0.0033 0.0034 0.0096
Loa Loa (eye worm) hypothetical protein 0.1358 0.3081 0.4625
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0002 0.0002
Plasmodium falciparum plasmepsin I 0.0048 0.0068 0.0131
Loa Loa (eye worm) hypothetical protein 0.0089 0.0163 0.0244
Echinococcus granulosus histone deacetylase 3 0.0356 0.0777 0.0777
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0016 0.0084
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0022 0.0008 0.0023
Brugia malayi Cathepsin L-like precursor 0.0026 0.0016 0.0025
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0813 0.1827 0.5164
Brugia malayi Matrixin family protein 0.1191 0.2698 0.405
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0036 0.0181
Echinococcus granulosus intermediate filament protein 0.0026 0.0018 0.0018
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.002 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0204 0.0426 0.064
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0121 0.0237 0.0336
Schistosoma mansoni hypothetical protein 0.0122 0.0239 0.0676
Brugia malayi Histone deacetylase 1 0.0356 0.0777 0.1167
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0 0.0001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0239 0.0239
Echinococcus granulosus thymidylate synthase 0.0121 0.0237 0.0237
Schistosoma mansoni endothelin-converting enzyme-related 0.0067 0.0112 0.0316
Echinococcus multilocularis musashi 0.0026 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.2525 0.5767 0.8657
Brugia malayi hypothetical protein 0.0019 0 0.0001
Entamoeba histolytica hypothetical protein 0.0019 0 0.0006
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.2292 0.523 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.0356 0.0535
Echinococcus multilocularis histone deacetylase 1 0.0356 0.0777 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0016 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0019 0 0.0001
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.1451 0.3295 0.6255
Onchocerca volvulus 0.0029 0.0024 0.0038
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0567 0.1263 0.1263
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0014 0.0071
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0036 0.0181
Trypanosoma cruzi histone deacetylase, putative 0.0417 0.0918 0.466
Mycobacterium tuberculosis Hypothetical protein 0.0058 0.009 0.0052
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0005 0.0005
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.1358 0.3081 0.8707
Leishmania major histone deacetylase, putative 0.0417 0.0918 0.466
Loa Loa (eye worm) peptidase family M13 containing protein 0.0204 0.0426 0.064
Loa Loa (eye worm) hypothetical protein 0.0208 0.0437 0.0656
Brugia malayi Matrixin family protein 0.1191 0.2698 0.405
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0036 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Onchocerca volvulus Matrix metalloproteinase homolog 0.2642 0.6036 0.9403
Brugia malayi dihydrofolate reductase family protein 0.0049 0.0071 0.0107
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0 0.0001
Mycobacterium ulcerans hydrolase 0.1451 0.3295 0.6275
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.2292 0.523 1
Echinococcus granulosus expressed protein 0.0363 0.0793 0.0793
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0014 0.0071
Entamoeba histolytica aminopeptidase, putative 0.0034 0.0036 0.0458
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0036 0.0101
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0016 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0016 0.0212
Leishmania major polypeptide deformylase-like protein, putative 0.0874 0.1969 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0036 0.0458
Loa Loa (eye worm) aminopeptidase in chromosome V 0.002 0.0005 0.0007
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0002 0.0004
Trypanosoma cruzi histone deacetylase, putative 0.0175 0.036 0.1829
Trypanosoma cruzi histone deacetylase 1, putative 0.0356 0.0777 0.3948
Loa Loa (eye worm) hypothetical protein 0.0276 0.0592 0.0888
Chlamydia trachomatis peptide deformylase 0.2292 0.523 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0272 0.0408
Brugia malayi PXA domain containing protein 0.0019 0 0.0001
Onchocerca volvulus 0.0026 0.0018 0.0028
Echinococcus granulosus lamin dm0 0.0026 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0035 0.0038 0.049
Leishmania major cathepsin L-like protease 0.0026 0.0016 0.0084
Trichomonas vaginalis set domain proteins, putative 0.023 0.0488 0.6273
Schistosoma mansoni regulator of G protein signaling 0.0019 0 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0024 0.0024
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0002 0.0025
Leishmania major cathepsin L-like protease 0.0026 0.0016 0.0084
Treponema pallidum polypeptide deformylase (def) 0.2292 0.523 0.5
Schistosoma mansoni hypothetical protein 0.0072 0.0123 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Echinococcus granulosus leucyl aminopeptidase 0.002 0.0005 0.0005
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0 0.0006
Schistosoma mansoni histone deacetylase 4 5 0.0417 0.0918 0.2593
Schistosoma mansoni serine/threonine protein kinase 0.0019 0 0.0001
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0016 0.0025
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0036 0.0181
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0036 0.0181
Echinococcus multilocularis histone deacetylase 8 0.0175 0.036 0.036
Plasmodium falciparum plasmepsin IV 0.0048 0.0068 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0 0.0001
Loa Loa (eye worm) aminopeptidase in chromosome III 0.002 0.0005 0.0007
Toxoplasma gondii thioredoxin reductase 0.0046 0.0063 0.0121
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.012 0.0233 0.0659
Brugia malayi Hemopexin family protein 0.1557 0.3539 0.5311
Echinococcus multilocularis thymidylate synthase 0.0121 0.0237 0.0237
Echinococcus multilocularis cysteine protease 0.0026 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0016 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0012
Schistosoma mansoni histone deacetylase 4 5 0.0417 0.0918 0.2593
Loa Loa (eye worm) hypothetical protein 0.1451 0.3295 0.4946
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0067 0.0112 0.0316
Echinococcus multilocularis adam 17 protease 0.1202 0.2722 0.2722
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0072 0.0123 0.0348
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.0496 0.0745
Toxoplasma gondii leucyl aminopeptidase LAP 0.0103 0.0194 0.037
Loa Loa (eye worm) histone deacetylase 7A 0.0417 0.0918 0.1377
Loa Loa (eye worm) hypothetical protein 0.012 0.0233 0.035
Schistosoma mansoni lamin 0.0026 0.0018 0.0051
Schistosoma mansoni histone deacetylase 0.0356 0.0777 0.2197
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0002 0.0002
Echinococcus granulosus cathepsin l1 0.0026 0.0016 0.0016
Plasmodium vivax histone deacetylase 1, putative 0.0356 0.0777 0.1487
Trypanosoma brucei trypanothione reductase 0.0046 0.0063 0.0322
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0022 0.0008 0.0042
Schistosoma mansoni regulator of G protein signaling 0.0019 0 0.0001
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0036 0.0036
Onchocerca volvulus 0.0026 0.0016 0.0026
Plasmodium vivax SET domain protein, putative 0.0029 0.0024 0.0047
Echinococcus granulosus disintegrin and metalloproteinase 0.012 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.0037
Loa Loa (eye worm) cysteine protease 0.0026 0.0016 0.0025
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.2292 0.523 1
Brugia malayi thymidylate synthase 0.0121 0.0237 0.0355
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0 0.0001
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0356 0.0777 1
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0048 0.0068 0.088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Schistosoma mansoni histone deacetylase hda2 0.0436 0.096 0.2713
Echinococcus granulosus histone deacetylase 6 0.0417 0.0918 0.0918
Plasmodium falciparum peptide deformylase 0.2292 0.523 1
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0016 0.0025
Echinococcus multilocularis histone deacetylase 6 0.0417 0.0918 0.0918
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0874 0.1969 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.1451 0.3295 0.4946
Schistosoma mansoni dihydrofolate reductase 0.0049 0.0071 0.0202
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0171 0.0351 0.0671
Schistosoma mansoni regulator of G protein signaling 0.0019 0 0.0001
Toxoplasma gondii histone deacetylase HDAC4 0.0348 0.0759 0.1451
Schistosoma mansoni DNA helicase recq1 0.0019 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0016 0.0084
Mycobacterium ulcerans leucyl aminopeptidase 0.0103 0.0194 0.0304
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0022 0.0008 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0038 0.0038
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0199 0.0262
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0103
Plasmodium falciparum histone deacetylase, putative 0.0417 0.0918 0.1755
Mycobacterium ulcerans thymidylate synthase 0.0121 0.0237 0.0387
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0016 0.0212
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0014 0.0027
Brugia malayi hypothetical protein 0.0035 0.0038 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0212
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0199 0.0247
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0165 0.0337 0.0952
Toxoplasma gondii histone deacetylase HDAC1 0.0417 0.0918 0.1755

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Concentration required for 50% inhibition of HCMV replication was measured using a Plaque reduction assay ChEMBL. 9057868
IC50 (functional) > 100 uM Antiviral activity was measured by plaque assay against HSV-1 virus by ELISA method ChEMBL. 9057868
IC50 (functional) > 100 uM Visual cytotoxicity was scored on HFF cells at time of HCMV plaque enumeration ChEMBL. 9057868
IC50 (functional) > 100 uM Visual cytotoxicity was scored on HFF cells at time of HCMV plaque enumeration ChEMBL. 9057868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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