Detailed information for compound 300051

Basic information

Technical information
  • TDR Targets ID: 300051
  • Name: (2R)-1-(tert-butylamino)-3-[(E)-1-cyclopropyl ethylideneamino]oxypropan-2-ol
  • MW: 228.331 | Formula: C12H24N2O2
  • H donors: 2 H acceptors: 1 LogP: 0.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H](CO/N=C(/C1CC1)\C)CNC(C)(C)C
  • InChi: 1S/C12H24N2O2/c1-9(10-5-6-10)14-16-8-11(15)7-13-12(2,3)4/h10-11,13,15H,5-8H2,1-4H3/b14-9+/t11-/m1/s1
  • InChiKey: IYQDIWRBEQWANY-ZECSTPGPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-1-(tert-butylamino)-3-[(E)-1-cyclopropylethylideneamino]oxy-propan-2-ol
  • (2R)-1-(tert-butylamino)-3-[(E)-1-cyclopropylethylideneamino]oxy-2-propanol
  • falintolol
  • (2R)-1-(tert-butylamino)-3-(1-cyclopropylethylideneamino)oxypropan-2-ol
  • (2R)-1-(tert-butylamino)-3-(1-cyclopropylethylideneamino)oxy-propan-2-ol
  • 96479-87-7
  • (R-(E))-1-Cyclopropylethanone O-(3-((1,1-dimethylethyl)amino)-2-hydroxypropyl)oxime
  • Ethanone, 1-cyclopropyl-, O-(3-((1,1-dimethylethyl)amino)-2-hydroxypropyl)oxime, (R-(E))-
  • O-(3-(tert-Butylamino)-2-hydroxypropyl)cyclopropyl methyl ketone oxime

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Beta-1 adrenergic receptor Starlite/ChEMBL References
Cavia porcellus Beta-2 adrenergic receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Mitochondrial inner membrane protein homolog Beta-2 adrenergic receptor   418 aa 346 aa 33.5 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Beta-2 adrenergic receptor   418 aa 366 aa 33.1 %
Echinococcus granulosus orexin receptor type 2 Beta-2 adrenergic receptor   418 aa 370 aa 24.1 %
Echinococcus multilocularis orexin receptor type 2 Beta-2 adrenergic receptor   418 aa 370 aa 24.3 %
Onchocerca volvulus Phospholipase d-related homolog Beta-2 adrenergic receptor   418 aa 385 aa 22.9 %
Onchocerca volvulus Beta-2 adrenergic receptor   418 aa 338 aa 19.5 %
Onchocerca volvulus Beta-2 adrenergic receptor   418 aa 348 aa 19.8 %
Schistosoma mansoni biogenic amine (5HT) receptor Beta-2 adrenergic receptor   418 aa 366 aa 31.7 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Beta-2 adrenergic receptor   418 aa 385 aa 33.5 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Beta-2 adrenergic receptor   418 aa 341 aa 25.2 %
Loa Loa (eye worm) hypothetical protein Beta-2 adrenergic receptor   418 aa 360 aa 23.3 %
Onchocerca volvulus Beta-2 adrenergic receptor   418 aa 352 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0301 0.0611 0.0596
Schistosoma mansoni Neurotrimin precursor (hNT) 0.029 0.0576 0.0694
Schistosoma mansoni myosin xvIII 0.0301 0.0611 0.0735
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.0194 0.0179
Loa Loa (eye worm) hypothetical protein 0.104 0.2796 0.2782
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0251 0.0461 0.1134
Schistosoma mansoni hypothetical protein 0.0301 0.0611 0.0735
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0288 0.0307
Echinococcus multilocularis neuropeptide receptor 0.0301 0.0611 0.0674
Schistosoma mansoni neuropeptide F-like receptor 0.0301 0.0611 0.0735
Echinococcus multilocularis lachesin 0.0161 0.0194 0.02
Echinococcus multilocularis peroxidasin 0.0161 0.0194 0.02
Brugia malayi Serotonin receptor 0.0301 0.0611 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Brugia malayi Protein kinase domain containing protein 0.0251 0.0461 0.0447
Brugia malayi sulfakinin receptor protein 0.0301 0.0611 0.0596
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0224 0.038 0.0362
Echinococcus multilocularis insulin receptor 0.1088 0.2936 0.3323
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0112 0.0051 0.0037
Schistosoma mansoni nephrin 0.017 0.0223 0.0269
Echinococcus granulosus cyclin dependent kinase 5 0.0224 0.038 0.0412
Brugia malayi Immunoglobulin I-set domain containing protein 0.0352 0.0759 0.0745
Onchocerca volvulus 0.0301 0.0611 0.0609
Echinococcus granulosus roundabout 2 0.017 0.0223 0.0233
Schistosoma mansoni histamine h1 receptor 0.0301 0.0611 0.0735
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0224 0.038 0.0897
Echinococcus multilocularis orexin receptor type 2 0.0301 0.0611 0.0674
Loa Loa (eye worm) AUR protein kinase 0.012 0.0075 0.0056
Schistosoma mansoni tyrosine kinase 0.162 0.4509 0.5428
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0301 0.0611 0.0674
Onchocerca volvulus 0.0301 0.0611 0.0609
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0075 0.009
Loa Loa (eye worm) hypothetical protein 0.0161 0.0194 0.0176
Onchocerca volvulus 0.0301 0.0611 0.0609
Echinococcus multilocularis neuropeptide FF receptor 2 0.0301 0.0611 0.0674
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0192 0.0288 0.0307
Entamoeba histolytica protein kinase domain containing protein 0.012 0.0075 0.0205
Brugia malayi SH2 domain containing protein 0.0368 0.0807 0.0793
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Brugia malayi SRC-1 0.0192 0.0288 0.0273
Schistosoma mansoni opsin-like receptor 0.0301 0.0611 0.0735
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus roundabout 2 0.046 0.108 0.1209
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0288 0.0307
Giardia lamblia Kinase, CMGC CDK 0.0224 0.038 0.7906
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0301 0.0611 0.0674
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0301 0.0611 0.0735
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.0194 0.0179
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.017 0.0223 0.0205
Brugia malayi Protein kinase domain containing protein 0.1088 0.2936 0.2925
Brugia malayi follicle stimulating hormone receptor 0.0301 0.0611 0.0596
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0288 0.0307
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Onchocerca volvulus 0.0301 0.0611 0.0609
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0301 0.0611 0.0593
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0473 0.1118 0.3063
Echinococcus granulosus tyrosine kinase 0.0115 0.006 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0301 0.0611 0.0674
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Echinococcus multilocularis neuropeptides capa receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) hypothetical protein 0.0164 0.0206 0.0187
Echinococcus granulosus insulin receptor 0.1088 0.2936 0.3323
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.0194 0.0179
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0301 0.0611 0.0674
Loa Loa (eye worm) hypothetical protein 0.0161 0.0194 0.0176
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.0194 0.0179
Echinococcus multilocularis c src tyrosine kinase 0.0134 0.0116 0.0111
Trypanosoma brucei cdc2-related kinase 1 0.0224 0.038 0.0897
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0251 0.0461 0.1134
Loa Loa (eye worm) hypothetical protein 0.017 0.0223 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0223 0.0208
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0134 0.0116 0.0111
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0282 0.0555 0.061
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0115 0.006 0.0046
Brugia malayi SH2 domain containing protein 0.0115 0.006 0.0044
Echinococcus multilocularis tyrosine protein kinase Blk 0.0173 0.0232 0.0243
Brugia malayi Protein kinase domain containing protein 0.0157 0.0185 0.0169
Plasmodium vivax protein kinase Crk2 0.0224 0.038 0.8211
Echinococcus multilocularis cyclin dependent kinase 1 0.0224 0.038 0.0412
Plasmodium falciparum protein serine/threonine kinase-1 0.0251 0.0461 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0368 0.0807 0.215
Loa Loa (eye worm) hypothetical protein 0.0161 0.0194 0.0176
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Schistosoma mansoni alpha-1 adrenergic receptor 0.0301 0.0611 0.0735
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0161 0.0194 0.0176
Echinococcus granulosus tyrosine protein kinase Src64B 0.0192 0.0288 0.0307
Onchocerca volvulus 0.0164 0.0206 0.0161
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0301 0.0611 0.0593
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0288 0.0307
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0301 0.0611 0.0735
Leishmania major protein kinase, putative 0.0251 0.0461 0.1134
Loa Loa (eye worm) neuropeptide F receptor 0.0301 0.0611 0.0593
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0282 0.0555 0.061
Entamoeba histolytica protein kinase domain containing protein 0.0368 0.0807 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0368 0.0807 0.079
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0368 0.0807 0.215
Entamoeba histolytica protein kinase , putative 0.012 0.0075 0.0205
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0192 0.0288 0.0307
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0473 0.1118 0.3063
Loa Loa (eye worm) TK/INSR protein kinase 0.1088 0.2936 0.2923
Brugia malayi serine/threonine-protein kinase 6 0.012 0.0075 0.006
Echinococcus granulosus hypothetical protein 0.0301 0.0611 0.0674
Echinococcus granulosus tyrosine protein kinase HCK 0.0143 0.0143 0.0142
Brugia malayi Fibronectin type III domain containing protein 0.03 0.0605 0.0591
Echinococcus granulosus Immunoglobulin 0.029 0.0576 0.0635
Schistosoma mansoni amine GPCR 0.0301 0.0611 0.0735
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1097 0.2965 0.3356
Loa Loa (eye worm) TK/ALK protein kinase 0.0332 0.0703 0.0685
Brugia malayi RE15519p 0.0301 0.0611 0.0596
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.012 0.0075 0.0205
Echinococcus granulosus G protein coupled receptor 139 0.0301 0.0611 0.0674
Echinococcus granulosus dual specificity 0.0368 0.0807 0.0898
Schistosoma mansoni amine GPCR 0.0301 0.0611 0.0735
Loa Loa (eye worm) hypothetical protein 0.0368 0.0807 0.0789
Echinococcus granulosus tyrosine protein kinase Blk 0.0173 0.0232 0.0243
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Schistosoma mansoni tyrosine kinase 0.0134 0.0116 0.014
Echinococcus multilocularis g protein coupled receptor 0.0301 0.0611 0.0674
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0192 0.0288 0.0307
Trypanosoma cruzi cdc2-related kinase 3 0.0224 0.038 0.0897
Echinococcus multilocularis Immunoglobulin 0.029 0.0576 0.0635
Loa Loa (eye worm) hypothetical protein 0.0218 0.0363 0.0345
Echinococcus multilocularis tyrosine protein kinase Srms 0.0173 0.0232 0.0243
Echinococcus granulosus neuropeptide receptor A26 0.0301 0.0611 0.0674
Echinococcus multilocularis epidermal growth factor receptor 0.162 0.4509 0.5116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Schistosoma mansoni ephrin receptor 0.025 0.0457 0.0551
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus hemicentin 1 0.0169 0.022 0.0229
Onchocerca volvulus 0.0301 0.0611 0.0609
Trypanosoma cruzi cdc2-related kinase 1 0.0224 0.038 0.0897
Echinococcus granulosus tyrosine protein kinase ABL1 0.0115 0.006 0.0046
Loa Loa (eye worm) TK protein kinase 0.0352 0.0759 0.0741
Loa Loa (eye worm) hypothetical protein 0.0161 0.0194 0.0176
Schistosoma mansoni biogenic amine (5HT) receptor 0.0301 0.0611 0.0735
Loa Loa (eye worm) G-protein coupled receptor 0.0301 0.0611 0.0593
Loa Loa (eye worm) hypothetical protein 0.0161 0.0194 0.0176
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Trypanosoma cruzi cdc2-related kinase 1 0.0224 0.038 0.0897
Loa Loa (eye worm) hypothetical protein 0.0244 0.0441 0.0422
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.2172 0.6142 0.6975
Loa Loa (eye worm) TK/EGFR protein kinase 0.2904 0.8307 0.8304
Onchocerca volvulus 0.0301 0.0611 0.0609
Brugia malayi Protein kinase domain containing protein 0.0333 0.0703 0.0688
Onchocerca volvulus Tyrosine kinase homolog 0.3173 0.9103 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Onchocerca volvulus Neuropeptide F receptor homolog 0.0301 0.0611 0.0609
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0192 0.0288 0.0307
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0161 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus biogenic amine 5HT receptor 0.0301 0.0611 0.0674
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.038 0.0458
Entamoeba histolytica protein kinase, putative 0.0368 0.0807 1
Echinococcus granulosus tyrosine protein kinase otk 0.0161 0.0194 0.02
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1272 0.3481 1
Echinococcus multilocularis G protein coupled receptor 139 0.0301 0.0611 0.0674
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0301 0.0611 0.0596
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Echinococcus granulosus tm gpcr rhodopsin 0.0301 0.0611 0.0674
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0301 0.0611 0.0674
Echinococcus multilocularis serotonin receptor 0.0301 0.0611 0.0674
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3069 0.8797 1
Brugia malayi hypothetical protein 0.0115 0.006 0.0044
Onchocerca volvulus 0.0301 0.0611 0.0609
Brugia malayi Immunoglobulin I-set domain containing protein 0.0101 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0217 0.036 0.0341
Brugia malayi Dopamine receptor 0.0301 0.0611 0.0596
Echinococcus granulosus neuropeptide Y receptor 0.0301 0.0611 0.0674
Brugia malayi AKH receptor 0.0301 0.0611 0.0596
Echinococcus multilocularis neuropeptides capa receptor 0.0301 0.0611 0.0674
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0461 0.0555
Echinococcus granulosus biogenic amine 5HT receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) hypothetical protein 0.0381 0.0847 0.0829
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0301 0.0611 0.0735
Brugia malayi neuropeptide F receptor 0.0301 0.0611 0.0596
Onchocerca volvulus 0.0301 0.0611 0.0609
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0301 0.0611 0.0735
Echinococcus granulosus allatostatin A receptor 0.0301 0.0611 0.0674
Entamoeba histolytica cell division protein kinase 2, putative 0.0224 0.038 0.429
Echinococcus multilocularis neuroglian 0.017 0.0223 0.0233
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0154 0.0175 0.0178
Loa Loa (eye worm) TK protein kinase 0.0173 0.0232 0.0213
Brugia malayi larval opioid receptor 0.0301 0.0611 0.0596
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0251 0.0461 0.0443
Echinococcus granulosus rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Leishmania major protein kinase, putative 0.0251 0.0461 0.1134
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Brugia malayi Furin-like cysteine rich region family protein 0.2904 0.8307 0.8304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Echinococcus granulosus neuropeptides capa receptor 0.0301 0.0611 0.0674
Echinococcus granulosus rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0301 0.0611 0.0674
Onchocerca volvulus 0.0301 0.0611 0.0609
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1097 0.2965 0.3356
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0192 0.0288 0.0307
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.104 0.2796 0.3365
Echinococcus granulosus twitchin 0.0366 0.0801 0.0891
Onchocerca volvulus 0.0301 0.0611 0.0609
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0301 0.0611 0.0674
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.012 0.0075 0.0205
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.162 0.4509 0.5116
Brugia malayi Tachykinin-like peptides receptor 99D 0.0301 0.0611 0.0596
Loa Loa (eye worm) TK/ABL protein kinase 0.0115 0.006 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0301 0.0611 0.0735
Echinococcus granulosus peroxidasin 0.0161 0.0194 0.02
Schistosoma mansoni septate junction protein 0.0161 0.0194 0.0234
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.104 0.2796 0.3163
Schistosoma mansoni tyrosine kinase 0.162 0.4509 0.5428
Echinococcus granulosus rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0301 0.0611 0.0609
Schistosoma mansoni tyrosine kinase 0.0246 0.0446 0.0537
Schistosoma mansoni hypothetical protein 0.0301 0.0611 0.0735
Brugia malayi Prion-like- 0.0161 0.0194 0.0179
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3476 1 1
Schistosoma mansoni tyrosine kinase 0.1088 0.2936 0.3534
Echinococcus multilocularis neuropeptide receptor A26 0.0301 0.0611 0.0674
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0301 0.0611 0.0674
Echinococcus granulosus ephrin type A receptor 4 A 0.0289 0.0573 0.0632
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.104 0.2796 0.3163
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus lachesin 0.0161 0.0194 0.02
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0301 0.0611 0.0674
Schistosoma mansoni septate junction protein 0.0161 0.0194 0.0234
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0134 0.0116 0.0111
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0192 0.0288 0.0307
Brugia malayi ephrin receptor 1 precursor 0.0163 0.02 0.0185
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Loa Loa (eye worm) TK/EPH protein kinase 0.0295 0.0591 0.0573
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0301 0.0611 0.0596
Loa Loa (eye worm) TK protein kinase 0.0143 0.0143 0.0125
Brugia malayi protein-tyrosine kinase 0.0173 0.0232 0.0217
Echinococcus multilocularis neuropeptide Y receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Brugia malayi neuropeptide F receptor 0.0301 0.0611 0.0596
Echinococcus granulosus contactin 0.0179 0.0249 0.0262
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0473 0.1118 0.3063
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0251 0.0461 0.1134
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus multilocularis roundabout 2 0.017 0.0223 0.0233
Echinococcus multilocularis hemicentin 1 0.0161 0.0194 0.02
Onchocerca volvulus 0.0301 0.0611 0.0609
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Echinococcus multilocularis sex peptide receptor 0.0301 0.0611 0.0674
Schistosoma mansoni growth hormone secretagogue receptor 0.0301 0.0611 0.0735
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Loa Loa (eye worm) hypothetical protein 0.0459 0.1077 0.106
Echinococcus granulosus neuropeptide receptor 0.0301 0.0611 0.0674
Echinococcus multilocularis tyrosine protein kinase shark 0.0115 0.006 0.0046
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.01 0.0015 0.0019
Onchocerca volvulus 0.0301 0.0611 0.0609
Loa Loa (eye worm) hypothetical protein 0.045 0.1051 0.1034
Echinococcus granulosus tyrosine protein kinase Lyn 0.0199 0.0309 0.0331
Loa Loa (eye worm) AUR protein kinase 0.012 0.0075 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.03 0.0605 0.0591
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0173 0.0232 0.0243
Schistosoma mansoni hypothetical protein 0.0301 0.0611 0.0735
Echinococcus granulosus g-protein coupled receptor 0.0301 0.0611 0.0674
Echinococcus granulosus tyrosine kinase 0.0173 0.0232 0.0243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.0194 0.0179
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Schistosoma mansoni adenoreceptor 0.0301 0.0611 0.0735
Schistosoma mansoni opsin-like receptor 0.0301 0.0611 0.0735
Echinococcus multilocularis neuropeptide Y receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Echinococcus multilocularis roundabout 2 0.017 0.0223 0.0233
Echinococcus multilocularis G-protein coupled receptor, putative 0.0301 0.0611 0.0674
Brugia malayi Protein kinase domain containing protein 0.0115 0.006 0.0044
Schistosoma mansoni cell adhesion molecule 0.017 0.0223 0.0269
Echinococcus multilocularis 0.0244 0.0441 0.048
Echinococcus multilocularis g protein coupled receptor 0.0301 0.0611 0.0674
Brugia malayi SH2 domain containing protein 0.0115 0.006 0.0044
Schistosoma mansoni neuropeptide f receptor 76f 0.0301 0.0611 0.0735
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Schistosoma mansoni protein kinase 0.012 0.0075 0.009
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0192 0.0288 0.0307
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Schistosoma mansoni tyrosine kinase 0.0115 0.006 0.0072
Loa Loa (eye worm) TK/ROR protein kinase 0.0154 0.0175 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Trichomonas vaginalis CMGC family protein kinase 0.0251 0.0461 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.017 0.0223 0.0233
Echinococcus granulosus rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Echinococcus multilocularis dro:myosuppressin receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.038 0.0458
Schistosoma mansoni biogenic amine receptor 0.0301 0.0611 0.0735
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0161 0.0194 0.0176
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0301 0.0611 0.0674
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0461 0.0555
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.017 0.0223 0.0233
Echinococcus granulosus neuroglian 0.017 0.0223 0.0233
Brugia malayi Serotonin receptor 0.0301 0.0611 0.0596
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.029 0.0576 0.0694
Echinococcus multilocularis serotonin receptor 0.0301 0.0611 0.0674
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0301 0.0611 0.0674
Echinococcus granulosus neuropeptides capa receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0224 0.038 0.0362
Schistosoma mansoni hypothetical protein 0.0301 0.0611 0.0735
Loa Loa (eye worm) TYRA-2 protein 0.0301 0.0611 0.0593
Echinococcus granulosus neuropeptide s receptor 0.0301 0.0611 0.0674
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.017 0.0223 0.0269
Echinococcus multilocularis cyclin dependent kinase 5 0.0224 0.038 0.0412
Schistosoma mansoni cell adhesion molecule 0.0161 0.0194 0.0234
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0368 0.0807 0.215
Trypanosoma brucei cdc2-related kinase 3 0.0224 0.038 0.0897
Brugia malayi G-protein coupled receptor 0.0301 0.0611 0.0596
Schistosoma mansoni neuropeptide receptor 0.0301 0.0611 0.0735
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1272 0.3481 0.3944
Toxoplasma gondii fructose-bisphospatase II 0.1272 0.3481 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus hypothetical protein 0.0244 0.0441 0.048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Echinococcus granulosus neuroglian 0.0359 0.0781 0.0868
Echinococcus granulosus neuropeptide receptor 0.0301 0.0611 0.0674
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0224 0.038 0.0897
Schistosoma mansoni roundabout 0.0161 0.0194 0.0234
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0177 0.0244 0.0226
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0282 0.0555 0.061
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0112 0.0051 0.0037
Echinococcus granulosus g protein coupled receptor 0.0301 0.0611 0.0674
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0224 0.038 0.0412
Loa Loa (eye worm) hypothetical protein 0.0361 0.0786 0.0769
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0301 0.0611 0.0735
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0301 0.0611 0.0735
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1272 0.3481 0.4191
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) SRC-1 0.0192 0.0288 0.027
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0251 0.0461 0.1134
Loa Loa (eye worm) hypothetical protein 0.0161 0.0194 0.0176
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0251 0.0461 0.1134
Loa Loa (eye worm) hypothetical protein 0.0498 0.1192 0.1175
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0301 0.0611 0.0674
Echinococcus granulosus tm gpcr rhodopsin 0.3069 0.8797 1
Echinococcus multilocularis contactin neuroglian septate junction protein 0.017 0.0223 0.0233
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.017 0.0223 0.0233
Echinococcus granulosus c src tyrosine kinase 0.0134 0.0116 0.0111
Echinococcus granulosus aurora kinase A 0.012 0.0075 0.0064
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1272 0.3481 0.3944
Echinococcus granulosus dro:myosuppressin receptor 0.0301 0.0611 0.0674
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) hypothetical protein 0.03 0.0605 0.0588
Brugia malayi Dopamine receptor protein 1 0.0301 0.0611 0.0596
Plasmodium vivax serine/threonine kinase-1, putative 0.0251 0.0461 1
Schistosoma mansoni nephrin 0.0369 0.081 0.0975
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Schistosoma mansoni cell adhesion molecule 0.017 0.0223 0.0269
Loa Loa (eye worm) hypothetical protein 0.0115 0.006 0.0041
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0381 0.0847 0.0943
Loa Loa (eye worm) hypothetical protein 0.0498 0.1192 0.1175
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Loa Loa (eye worm) neuropeptide F receptor 0.0301 0.0611 0.0593
Echinococcus granulosus dual specificity protein kinase clk2 0.0251 0.0461 0.0504
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Onchocerca volvulus 0.0301 0.0611 0.0609
Schistosoma mansoni opsin-like receptor 0.0301 0.0611 0.0735
Brugia malayi Melatonin receptor type 1A 0.0301 0.0611 0.0596
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0301 0.0611 0.0674
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0223 0.0208
Brugia malayi serine/threonine kinase 12 0.012 0.0075 0.006
Loa Loa (eye worm) hypothetical protein 0.03 0.0605 0.0588
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0301 0.0611 0.0596
Echinococcus multilocularis cyclin dependent kinase 0.0224 0.038 0.0412
Schistosoma mansoni cell adhesion molecule 0.0391 0.0876 0.1054
Brugia malayi Protein kinase domain containing protein 0.0368 0.0807 0.0793
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0301 0.0611 0.0735
Echinococcus granulosus tm gpcr rhodopsin 0.0301 0.0611 0.0674
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0288 0.0307
Brugia malayi Tyrosine-protein kinase abl-1 0.0134 0.0116 0.0101
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0288 0.0307
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0301 0.0611 0.0674
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1272 0.3481 0.3469
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Brugia malayi cell division control protein 2 homolog 0.0224 0.038 0.0366
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1272 0.3481 1
Onchocerca volvulus 0.301 0.8621 0.9467
Schistosoma mansoni tyrosine kinase 0.1534 0.4258 0.5125
Echinococcus multilocularis epidermal growth factor receptor 0.2904 0.8307 0.9442
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.012 0.0075 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0224 0.038 0.7906
Brugia malayi Protein kinase domain containing protein 0.0224 0.038 0.0366
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus neuropeptide FF receptor 2 0.0301 0.0611 0.0674
Brugia malayi Peroxidasin 0.0161 0.0194 0.0179
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) hypothetical protein 0.029 0.0576 0.0558
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0028 0.0033
Echinococcus multilocularis fmrfamide receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) melatonin receptor type 1A 0.0301 0.0611 0.0593
Entamoeba histolytica cell division protein kinase 2, putative 0.0224 0.038 0.429
Brugia malayi GnHR receptor homolog 0.0301 0.0611 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Echinococcus granulosus somatostatin receptor 0.0301 0.0611 0.0674
Echinococcus granulosus peptide allatostatin:somatostatin 0.0301 0.0611 0.0674
Echinococcus multilocularis somatostatin receptor 0.0301 0.0611 0.0674
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0301 0.0611 0.0596
Echinococcus granulosus g protein coupled receptor 0.0301 0.0611 0.0674
Brugia malayi G protein-coupled receptor F59B2.13 0.0301 0.0611 0.0596
Loa Loa (eye worm) hypothetical protein 0.0161 0.0194 0.0176
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Schistosoma mansoni tyrosine kinase 0.0192 0.0288 0.0347
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Echinococcus granulosus tachykinin peptides receptor 99D 0.0301 0.0611 0.0674
Schistosoma mansoni titin 0.0169 0.022 0.0265
Brugia malayi Immunoglobulin I-set domain containing protein 0.017 0.0223 0.0208
Echinococcus multilocularis neuroglian 0.0359 0.0781 0.0868
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0301 0.0611 0.0593
Schistosoma mansoni tyrosine kinase 0.1534 0.4258 0.5125
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus multilocularis aurora kinase A 0.012 0.0075 0.0064
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0301 0.0611 0.0674
Echinococcus granulosus serotonin receptor 0.0301 0.0611 0.0674
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0301 0.0611 0.0674
Echinococcus granulosus neuropeptide Y receptor 0.0301 0.0611 0.0674
Schistosoma mansoni neuropeptide receptor 0.0301 0.0611 0.0735
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.012 0.0075 0.0064
Schistosoma mansoni tyrosine kinase 0.2904 0.8307 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Brugia malayi G-protein coupled receptor 0.0301 0.0611 0.0596
Entamoeba histolytica protein kinase, putative 0.012 0.0075 0.0205
Schistosoma mansoni biogenic amine receptor 0.0301 0.0611 0.0735
Brugia malayi Protein kinase domain containing protein 0.0115 0.006 0.0044
Echinococcus granulosus serine:threonine protein kinase 12 B 0.012 0.0075 0.0064
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0224 0.038 0.0897
Echinococcus multilocularis tyrosine protein kinase otk 0.0161 0.0194 0.02
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.017 0.0223 0.0233
Echinococcus multilocularis Immunoglobulin 0.029 0.0576 0.0635
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1272 0.3481 1
Loa Loa (eye worm) G-protein coupled receptor 0.0301 0.0611 0.0593
Echinococcus multilocularis cyclin dependent kinase 1 0.0224 0.038 0.0412
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0134 0.0116 0.014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0301 0.0611 0.0735
Echinococcus multilocularis g protein coupled receptor 0.0301 0.0611 0.0674
Brugia malayi putative neuropeptide receptor NPR1 0.0301 0.0611 0.0596
Echinococcus multilocularis tyrosine protein kinase Abl 0.0134 0.0116 0.0111
Brugia malayi Protein kinase domain containing protein 0.0115 0.006 0.0044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0301 0.0611 0.0735
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Schistosoma mansoni tyrosine kinase 0.0134 0.0116 0.014
Brugia malayi hypothetical protein 0.0301 0.0611 0.0596
Giardia lamblia Kinase, CMGC CDK 0.0224 0.038 0.7906
Onchocerca volvulus 0.0301 0.0611 0.0609
Onchocerca volvulus 0.0301 0.0611 0.0609
Echinococcus granulosus orexin receptor type 2 0.0301 0.0611 0.0674
Trypanosoma cruzi cdc2-related kinase 3 0.0224 0.038 0.0897
Schistosoma mansoni vesicular amine transporter 0.029 0.0576 0.0694
Schistosoma mansoni amine GPCR 0.0301 0.0611 0.0735
Onchocerca volvulus 0.0301 0.0611 0.0609
Echinococcus multilocularis dual specificity protein kinase clk2 0.0251 0.0461 0.0504
Loa Loa (eye worm) hypothetical protein 0.0361 0.0786 0.0769
Echinococcus multilocularis dual specificity 0.0368 0.0807 0.0898
Loa Loa (eye worm) hypothetical protein 0.029 0.0576 0.0558
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0161 0.0194 0.0234
Schistosoma mansoni tyrosine kinase 0.0282 0.0555 0.0668
Entamoeba histolytica protein kinase, putative 0.0143 0.0143 0.1117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Schistosoma mansoni serine/threonine protein kinase 0.0368 0.0807 0.0972
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0301 0.0611 0.0674
Schistosoma mansoni amine GPCR 0.0301 0.0611 0.0735
Brugia malayi serine/threonine protein kinase 6 0.012 0.0075 0.006
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) AUR protein kinase 0.012 0.0075 0.0056
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0224 0.038 0.0362
Echinococcus granulosus roundabout 2 0.017 0.0223 0.0233
Brugia malayi hypothetical protein 0.0498 0.1192 0.1178
Echinococcus granulosus cyclin dependent kinase 0.0224 0.038 0.0412
Brugia malayi Protein kinase domain containing protein 0.0115 0.006 0.0044
Echinococcus granulosus epidermal growth factor receptor 0.162 0.4509 0.5116
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus tyrosine protein kinase Srms 0.0115 0.006 0.0046
Echinococcus granulosus g protein coupled receptor 0.0301 0.0611 0.0674
Echinococcus multilocularis g-protein coupled receptor 0.0301 0.0611 0.0674
Trichomonas vaginalis CMGC family protein kinase 0.0224 0.038 0.7906
Echinococcus multilocularis hemicentin 1 0.0169 0.022 0.0229
Brugia malayi fructose-1,6-bisphosphatase 0.1272 0.3481 0.3471
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Trichomonas vaginalis CMGC family protein kinase 0.0224 0.038 0.7906
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301 0.0611 0.0674
Echinococcus granulosus tyrosine protein kinase Src42A 0.0192 0.0288 0.0307
Schistosoma mansoni tyrosine kinase 0.0192 0.0288 0.0347
Schistosoma mansoni tyrosine kinase 0.1088 0.2936 0.3534
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0473 0.1118 0.3063
Plasmodium vivax serine/threonine protein kinase 6, putative 0.012 0.0075 0.1455
Schistosoma mansoni neuropeptide receptor 0.0301 0.0611 0.0735
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0192 0.0288 0.0307
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301 0.0611 0.0735
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0368 0.0807 0.215
Echinococcus granulosus tyrosine protein kinase shark 0.0115 0.006 0.0046
Brugia malayi Protein kinase domain containing protein 0.0115 0.006 0.0044
Echinococcus granulosus epidermal growth factor receptor 0.2904 0.8307 0.9442
Entamoeba histolytica protein kinase, putative 0.0368 0.0807 1
Loa Loa (eye worm) hypothetical protein 0.03 0.0605 0.0588
Brugia malayi putative neuropeptide receptor 0.0301 0.0611 0.0596
Schistosoma mansoni biogenic amine receptor 0.0301 0.0611 0.0735
Echinococcus granulosus fmrfamide receptor 0.0301 0.0611 0.0674
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0154 0.0175 0.0178
Schistosoma mansoni tyrosine kinase 0.0115 0.006 0.0072
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.0194 0.0179
Echinococcus multilocularis 0.0876 0.2311 0.2611
Echinococcus multilocularis ephrin type A receptor 4 A 0.0289 0.0573 0.0632
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0301 0.0611 0.0593
Echinococcus granulosus alpha 1A adrenergic receptor 0.0301 0.0611 0.0674
Entamoeba histolytica hypothetical protein 0.0368 0.0807 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0143 0.0143 0.0142
Echinococcus multilocularis neuropeptide s receptor 0.0301 0.0611 0.0674
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0301 0.0611 0.0735
Plasmodium falciparum protein kinase 5 0.0224 0.038 0.7906
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0301 0.0611 0.0593
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus sex peptide receptor 0.0301 0.0611 0.0674
Echinococcus multilocularis tyrosine kinase 0.0115 0.006 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0301 0.0611 0.0674
Leishmania major 0.1272 0.3481 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0301 0.0611 0.0735
Schistosoma mansoni neuropeptide receptor 0.0301 0.0611 0.0735
Echinococcus multilocularis allatostatin A receptor 0.0301 0.0611 0.0674
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0301 0.0611 0.0674
Onchocerca volvulus 0.0301 0.0611 0.0609
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0173 0.0232 0.0243
Schistosoma mansoni amine GPCR 0.0301 0.0611 0.0735
Schistosoma mansoni neuropeptide F-like receptor 0.0301 0.0611 0.0735
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Echinococcus granulosus fibroblast growth factor receptor 4 0.0282 0.0555 0.061
Brugia malayi hypothetical protein 0.03 0.0605 0.0591
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0115 0.006 0.0046
Echinococcus multilocularis fmrfamide receptor 0.0301 0.0611 0.0674
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0251 0.0461 0.1134
Echinococcus granulosus cyclin dependent kinase 1 0.0224 0.038 0.0412
Echinococcus multilocularis basement membrane specific heparan sulfate 0.029 0.0576 0.0635
Echinococcus granulosus defective proboscis extension response 0.029 0.0576 0.0635
Echinococcus granulosus 7TM GPCR rhodopsin 0.0301 0.0611 0.0674
Schistosoma mansoni tyrosine kinase 0.1534 0.4258 0.5125
Echinococcus granulosus 7tm_1 domain containing protein 0.0301 0.0611 0.0674
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0169 0.022 0.0177
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.006 0.0041
Brugia malayi G protein-coupled receptor 0.0301 0.0611 0.0596
Echinococcus multilocularis roundabout 2 0.046 0.108 0.1209
Schistosoma mansoni neuroglian 0.017 0.0223 0.0269
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0301 0.0611 0.0735
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0115 0.006 0.0046
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0301 0.0611 0.0735
Brugia malayi ORL1-like opioid receptor 0.0301 0.0611 0.0596
Toxoplasma gondii fructose-bisphospatase I 0.0473 0.1118 0.3063
Giardia lamblia Kinase, CMGC CLK 0.0251 0.0461 1
Loa Loa (eye worm) hypothetical protein 0.029 0.0576 0.0558
Brugia malayi Dopamine receptor protein 2 0.0301 0.0611 0.0596
Loa Loa (eye worm) hypothetical protein 0.0301 0.0611 0.0593
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0251 0.0461 0.1134
Entamoeba histolytica protein kinase, putative 0.012 0.0075 0.0205

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 7.72 In vitro inhibitory activity against beta-2 adrenergic receptor determined as pA2 in guinea pig trachea ChEMBL. 2861288
Kd (binding) = 8.07 In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atria ChEMBL. 2861288
pA2 (binding) = 7.72 In vitro inhibitory activity against beta-2 adrenergic receptor determined as pA2 in guinea pig trachea ChEMBL. 2861288
pA2 (binding) = 8.07 In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atria ChEMBL. 2861288

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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