TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 528.685 | Formula: C32H40N4O3
H donors: 3 H acceptors: 2 LogP: 6.21 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N[C@@H](C(=O)N[C@H](CNc1ccc(cc1)N1CCCCC1)CCc1ccccc1)C)OCc1ccccc1
InChi: 1S/C32H40N4O3/c1-25(34-32(38)39-24-27-13-7-3-8-14-27)31(37)35-29(16-15-26-11-5-2-6-12-26)23-33-28-17-19-30(20-18-28)36-21-9-4-10-22-36/h2-3,5-8,11-14,17-20,25,29,33H,4,9-10,15-16,21-24H2,1H3,(H,34,38)(H,35,37)/t25-,29+/m1/s1
InChiKey: PUVIOAPORHOQCE-IRPSRAIASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Echinococcus multilocularis	SH2 motif	0.0071	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Onchocerca volvulus		0.0137	0.2149	1
Loa Loa (eye worm)	cathepsin B	0.0065	0.0158	0.044
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0069	0.0274	0.0274
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0071	0.0322	0.0322
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0071	0.0322	0.0322
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0865	0.2405
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0865	0.2405
Schistosoma mansoni	cell polarity protein	0.0069	0.0274	0.0338
Onchocerca volvulus		0.0071	0.0322	0.15
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Plasmodium vivax	vivapain-2	0.0059	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0865	0.2405
Echinococcus granulosus	c src tyrosine kinase	0.0159	0.275	0.275
Echinococcus multilocularis	nostrin	0.0069	0.0274	0.0274
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0071	0.0322	0.0397
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0102	0.117	0.117
Loa Loa (eye worm)	animal heme peroxidase	0.0137	0.2149	0.5973
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.019	0.3597	0.3597
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.3196	0.3939
Schistosoma mansoni	adapter molecule crk	0.014	0.2207	0.272
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0065	0.0158	0.0495
Brugia malayi	SH2 domain containing protein	0.0071	0.0322	0.0896
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0069	0.0274	0.0274
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Echinococcus granulosus	tensin	0.0071	0.0322	0.0322
Entamoeba histolytica	hypothetical protein	0.0069	0.0274	0.3172
Echinococcus granulosus	expressed conserved protein	0.0071	0.0322	0.0322
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0122	0.1712	0.1712
Schistosoma mansoni	apoptosis stimulating of P53	0.0069	0.0274	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Echinococcus granulosus	SH2 motif	0.0071	0.0322	0.0322
Entamoeba histolytica	hypothetical protein, conserved	0.0069	0.0274	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0176	0.3196	1
Leishmania major	hypothetical protein, conserved	0.0069	0.0274	1
Echinococcus multilocularis	transfer RNA-Ala	0.0069	0.0274	0.0274
Echinococcus granulosus	N chimaerin	0.0071	0.0322	0.0322
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0069	0.0274	0.0274
Loa Loa (eye worm)	thyroid receptor interactor	0.0069	0.0274	0.0763
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0071	0.0322	0.0397
Onchocerca volvulus		0.0137	0.2149	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0159	0.275	0.275
Echinococcus multilocularis	endophilin A3	0.0069	0.0274	0.0274
Schistosoma mansoni	SH2A	0.0071	0.0322	0.0397
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.014	0.2207	0.272
Schistosoma mansoni	tyrosine kinase	0.0159	0.275	0.3388
Schistosoma mansoni	growth factor receptor-bound protein	0.014	0.2207	0.272
Onchocerca volvulus	Chorion peroxidase homolog	0.0137	0.2149	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0122	0.1712	0.1712
Brugia malayi	protein-tyrosine kinase	0.0122	0.1712	0.476
Brugia malayi	Peroxidasin	0.0137	0.2149	0.5973
Brugia malayi	SH2 domain containing protein	0.0071	0.0322	0.0896
Loa Loa (eye worm)	animal heme peroxidase	0.0137	0.2149	0.5973
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.019	0.3597	0.3597
Schistosoma mansoni	tensin	0.0071	0.0322	0.0397
Schistosoma mansoni	vav2	0.0073	0.0397	0.0489
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.0817	0.1007
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Trichomonas vaginalis	p67phox protein, putative	0.0069	0.0274	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0071	0.0322	0.15
Brugia malayi	cathepsin B-like cysteine proteinase	0.0176	0.3196	0.8886
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0274	0.0763
Schistosoma mansoni	tensin-related	0.0071	0.0322	0.0397
Echinococcus granulosus	growth factor receptor bound protein 2	0.014	0.2207	0.2207
Brugia malayi	Animal haem peroxidase family protein	0.0137	0.2149	0.5973
Schistosoma mansoni	tyrosine kinase	0.0356	0.8115	1
Entamoeba histolytica	hypothetical protein	0.0069	0.0274	0.3172
Echinococcus granulosus	Spectrin alpha actinin	0.0069	0.0274	0.0274
Loa Loa (eye worm)	animal heme peroxidase	0.0137	0.2149	0.5973
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0425	1	1
Onchocerca volvulus	Peroxidase homolog	0.0137	0.2149	1
Onchocerca volvulus		0.0071	0.0322	0.15
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0071	0.0322	0.0896
Loa Loa (eye worm)	STAT protein	0.0071	0.0322	0.0896
Schistosoma mansoni	hypothetical protein	0.0071	0.0322	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0073	0.0397	0.1104
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0069	0.0274	0.0338
Echinococcus multilocularis	tensin	0.0071	0.0322	0.0322
Schistosoma mansoni	run and tbc1 domain containing	0.0069	0.0274	0.0338
Schistosoma mansoni	tyrosine kinase	0.0091	0.0865	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0397	0.1104
Onchocerca volvulus		0.0069	0.0274	0.1277
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Onchocerca volvulus		0.0071	0.0322	0.15
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.019	0.3597	0.3597
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Onchocerca volvulus		0.0069	0.0274	0.1277
Entamoeba histolytica	SH2 domain containing protein	0.0071	0.0322	0.3727
Echinococcus granulosus	intersectin 2	0.0069	0.0274	0.0274
Onchocerca volvulus		0.0091	0.0865	0.4026
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0122	0.1712	0.1712
Brugia malayi	RhoGAP domain containing protein	0.0071	0.0322	0.0896
Entamoeba histolytica	hypothetical protein	0.0069	0.0274	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Loa Loa (eye worm)	SH2 domain-containing protein	0.0071	0.0322	0.0896
Echinococcus multilocularis	expressed protein	0.0069	0.0274	0.0274
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0071	0.0322	0.0322
Echinococcus multilocularis	growth factor receptor bound protein 2	0.014	0.2207	0.2207
Brugia malayi	hypothetical protein	0.0137	0.2149	0.5973
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0069	0.0274	0.0274
Echinococcus granulosus	tyrosine protein kinase Fyn	0.019	0.3597	0.3597
Schistosoma mansoni	sorting nexin	0.0069	0.0274	0.0338
Schistosoma mansoni	tyrosine kinase	0.0159	0.275	0.3388
Brugia malayi	Tyrosine-protein kinase abl-1	0.0159	0.275	0.7645
Schistosoma mansoni	C-fyn	0.0069	0.0274	0.0338
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.019	0.3597	0.3597
Brugia malayi	Animal haem peroxidase family protein	0.0137	0.2149	0.5973
Brugia malayi	SH2 domain containing protein	0.0071	0.0322	0.0896
Onchocerca volvulus	Dual oxidase homolog	0.0137	0.2149	1
Schistosoma mansoni	tyrosine kinase	0.019	0.3597	0.4432
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0069	0.0274	0.0274
Echinococcus granulosus	NCK adaptor protein	0.014	0.2207	0.2207
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0071	0.0322	0.0896
Brugia malayi	Animal haem peroxidase family protein	0.0137	0.2149	0.5973
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0069	0.0274	0.0274
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0059	0	0.5
Echinococcus multilocularis	tyrosine kinase	0.0091	0.0865	0.0865
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0069	0.0274	0.0338
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0091	0.0865	0.0865
Echinococcus multilocularis	SH2 motif	0.0071	0.0322	0.0322
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0069	0.0274	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Onchocerca volvulus		0.0091	0.0865	0.4026
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0274	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0071	0.0322	0.0322
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0071	0.0322	0.0322
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0071	0.0322	0.0896
Loa Loa (eye worm)	hypothetical protein	0.014	0.2207	0.6136
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0071	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Onchocerca volvulus	Peroxidasin homolog	0.0137	0.2149	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0071	0.0322	0.0322
Brugia malayi	Variant SH3 domain containing protein	0.0071	0.0322	0.0896
Echinococcus granulosus	tyrosine protein kinase Lyn	0.019	0.3597	0.3597
Brugia malayi	Tensin	0.0071	0.0322	0.0896
Schistosoma mansoni	peroxidasin	0.0137	0.2149	0.2648
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0069	0.0274	0.0858
Onchocerca volvulus		0.0069	0.0274	0.1277
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0071	0.0322	0.0322
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0059	0	0.5
Brugia malayi	SH2 domain containing protein	0.0091	0.0865	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Echinococcus granulosus	tyrosine kinase	0.0122	0.1712	0.1712
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0274	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.019	0.3597	0.3597
Toxoplasma gondii	cathepsin B	0.0065	0.0158	1
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0069	0.0274	0.0274
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0069	0.0274	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.014	0.2207	0.6136
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0274	1
Echinococcus granulosus	nostrin	0.0069	0.0274	0.0274
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0071	0.0322	0.0896
Brugia malayi	Variant SH3 domain containing protein	0.0073	0.0397	0.1104
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.3196	0.3939
Loa Loa (eye worm)	SRC-1	0.019	0.3597	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0071	0.0322	0.0322
Echinococcus multilocularis	tensin	0.0071	0.0322	0.0322
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0072	0.0349	0.0349
Echinococcus granulosus	peroxidasin	0.0137	0.2149	0.2149
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0091	0.0865	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.019	0.3597	0.3597
Loa Loa (eye worm)	TK/ABL protein kinase	0.0091	0.0865	0.2405
Echinococcus granulosus	SH2 domain containing protein 7	0.0071	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Schistosoma mansoni	formin binding protein and related proteins	0.0069	0.0274	0.0338
Echinococcus granulosus	tyrosine protein kinase shark	0.0091	0.0865	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Echinococcus granulosus	hypothetical protein	0.0071	0.0322	0.0322
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0071	0.0322	0.15
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Echinococcus granulosus	SH2 motif	0.0071	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.019	0.3597	0.3597
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0071	0.0322	0.0322
Echinococcus multilocularis	SH2 domain containing protein 7	0.0071	0.0322	0.0322
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0071	0.0322	0.0322
Loa Loa (eye worm)	blistered cuticle protein 3	0.0137	0.2149	0.5973
Entamoeba histolytica	hypothetical protein, conserved	0.0069	0.0274	0.3172
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0274	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0069	0.0274	0.0858
Schistosoma mansoni	eps8-related protein	0.0069	0.0274	0.0338
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0071	0.0322	0.3727
Echinococcus multilocularis	tyrosine protein kinase shark	0.0091	0.0865	0.0865
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.019	0.3597	0.3597
Loa Loa (eye worm)	TK protein kinase	0.0122	0.1712	0.476
Brugia malayi	SH3 domain containing protein	0.0069	0.0274	0.0763
Schistosoma mansoni	tensin	0.0071	0.0322	0.0397
Schistosoma mansoni	tensin	0.0071	0.0322	0.0397
Giardia lamblia	Cathepsin B precursor	0.0065	0.0158	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0071	0.0322	0.0322
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0069	0.0274	0.0338
Echinococcus granulosus	tyrosine protein kinase Src64B	0.019	0.3597	0.3597
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0071	0.0322	0.0397
Echinococcus multilocularis	NCK adaptor protein	0.014	0.2207	0.2207
Brugia malayi	Myosin tail family protein	0.0069	0.0274	0.0763
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0865	0.2405
Brugia malayi	SH2 domain containing protein	0.0071	0.0322	0.0896
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0069	0.0274	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Schistosoma mansoni	dynamin-associated protein	0.0069	0.0274	0.0338
Echinococcus multilocularis	SHC transforming protein 3	0.0071	0.0322	0.0322
Echinococcus multilocularis	N chimaerin	0.0071	0.0322	0.0322
Brugia malayi	Animal haem peroxidase family protein	0.0137	0.2149	0.5973
Echinococcus multilocularis	cathepsin b	0.0176	0.3196	0.3196
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Onchocerca volvulus		0.0137	0.2149	1
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0274	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0071	0.0322	0.0322
Entamoeba histolytica	protein kinase, putative	0.0069	0.0274	0.3172
Schistosoma mansoni	hypothetical protein	0.0069	0.0274	0.0338
Echinococcus multilocularis		0.0071	0.0322	0.0322
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0069	0.0274	0.0763
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.3196	0.3939
Loa Loa (eye worm)	hypothetical protein	0.0176	0.3196	0.8886
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Giardia lamblia	Cathepsin B precursor	0.0065	0.0158	0.5
Brugia malayi	hypothetical protein	0.0071	0.0322	0.0896
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0274	0.0763
Entamoeba histolytica	unconventional myosin IB	0.0069	0.0274	0.3172
Brugia malayi	Guanylate kinase family protein	0.0069	0.0274	0.0763
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0065	0.0158	0.5762
Echinococcus granulosus	tyrosine protein kinase Blk	0.0122	0.1712	0.1712
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0071	0.0322	0.0322
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Brugia malayi	SH2 domain containing protein	0.0071	0.0322	0.0896
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0274	0.0763
Echinococcus granulosus	expressed protein	0.0069	0.0274	0.0274
Brugia malayi	hypothetical protein	0.0091	0.0865	0.2405
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0071	0.0322	0.0322
Onchocerca volvulus	Peroxidase homolog	0.0137	0.2149	1
Onchocerca volvulus		0.0071	0.0322	0.15
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0071	0.0322	0.0896
Schistosoma mansoni	peroxidasin	0.0137	0.2149	0.2648
Brugia malayi	Variant SH3 domain containing protein	0.014	0.2207	0.6136
Onchocerca volvulus		0.0069	0.0274	0.1277
Brugia malayi	Animal haem peroxidase family protein	0.0137	0.2149	0.5973
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Brugia malayi	Peripheral plasma membrane protein CASK	0.0069	0.0274	0.0763
Echinococcus multilocularis	SH2 motif	0.0071	0.0322	0.0322
Onchocerca volvulus	Putative cortactin	0.0069	0.0274	0.1277
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0069	0.0274	0.3172
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0159	0.275	0.3388
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Loa Loa (eye worm)	SH2 domain-containing protein	0.0071	0.0322	0.0896
Brugia malayi	Blistered cuticle protein 3	0.0137	0.2149	0.5973
Echinococcus multilocularis	intersectin 2	0.0069	0.0274	0.0274
Schistosoma mansoni	Dab2-interacting protein-like	0.0069	0.0274	0.0338
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0091	0.0865	0.0865
Brugia malayi	SH2 domain containing protein	0.0071	0.0322	0.0896
Echinococcus granulosus	cathepsin b	0.0176	0.3196	0.3196
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0071	0.0322	0.0397
Schistosoma mansoni	dreadlocks/dock	0.0069	0.0274	0.0338
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0091	0.0865	0.0865
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0071	0.0322	0.0322
Echinococcus granulosus	src region	0.0069	0.0274	0.0274
Echinococcus granulosus	tyrosine kinase	0.0091	0.0865	0.0865
Onchocerca volvulus		0.0071	0.0322	0.15
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.019	0.3597	0.3597
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0274	0.0763
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0102	0.117	0.117
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.019	0.3597	0.3597
Brugia malayi	protein-tyrosine kinase	0.0069	0.0274	0.0763
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0865	0.2405
Entamoeba histolytica	protein kinase, putative	0.0071	0.0322	0.3727
Echinococcus multilocularis	c src tyrosine kinase	0.0159	0.275	0.275
Echinococcus multilocularis	cathepsin b	0.0176	0.3196	0.3196
Schistosoma mansoni	growth factor receptor-bound protein	0.014	0.2207	0.272
Loa Loa (eye worm)	animal heme peroxidase	0.0137	0.2149	0.5973
Loa Loa (eye worm)	guanylate kinase	0.0069	0.0274	0.0763
Brugia malayi	SRC-1	0.019	0.3597	1
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0274	0.0763
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.019	0.3597	0.3597
Brugia malayi	SH2 domain containing protein	0.0071	0.0322	0.0896
Entamoeba histolytica	hypothetical protein	0.0072	0.0349	0.4036
Onchocerca volvulus		0.0069	0.0274	0.1277
Entamoeba histolytica	hypothetical protein	0.0069	0.0274	0.3172
Brugia malayi	Src substrate cortactin	0.0069	0.0274	0.0763
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0065	0.0158	0.0195
Entamoeba histolytica	hypothetical protein	0.0069	0.0274	0.3172
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0274	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.019	0.3597	0.3597
Brugia malayi	Sex muscle abnormal protein 5	0.014	0.2207	0.6136
Onchocerca volvulus		0.0091	0.0865	0.4026
Schistosoma mansoni	nck2/grb4	0.014	0.2207	0.272
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0176	0.3196	0.3939
Schistosoma mansoni	shc transforming protein	0.0071	0.0322	0.0397
Echinococcus multilocularis	Spectrin alpha actinin	0.0069	0.0274	0.0274
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Schistosoma mansoni	tyrosine kinase	0.019	0.3597	0.4432
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0059	0	0.5
Echinococcus multilocularis	peroxidasin	0.0137	0.2149	0.2149
Onchocerca volvulus		0.0071	0.0322	0.15
Giardia lamblia	Cathepsin B precursor	0.0065	0.0158	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0069	0.0274	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0065	0.0158	0.5762
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0072	0.0349	0.043
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0091	0.0865	0.0865
Schistosoma mansoni	suppressor of cytokine signaling	0.0071	0.0322	0.0397
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0071	0.0322	0.0896
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0069	0.0274	0.0274
Loa Loa (eye worm)	SH2 domain-containing protein	0.0071	0.0322	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Loa Loa (eye worm)	TK/FER protein kinase	0.0091	0.0865	0.2405
Loa Loa (eye worm)	protein-tyrosine kinase	0.0069	0.0274	0.0763
Schistosoma mansoni	sorbin	0.0069	0.0274	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0322	0.0896
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0072	0.0349	0.0349
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0071	0.0322	0.0322
Brugia malayi	SH2 domain containing protein	0.0091	0.0865	0.2405
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0865	0.2405
Onchocerca volvulus	Peroxidasin homolog	0.0137	0.2149	1
Entamoeba histolytica	hypothetical protein	0.0069	0.0274	0.3172
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.019	0.3597	0.3597
Onchocerca volvulus		0.0091	0.0865	0.4026
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0274	0.0763
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0071	0.0322	0.0896
Schistosoma mansoni	tensin-related	0.0071	0.0322	0.0397
Schistosoma mansoni	hypothetical protein	0.0069	0.0274	0.0338
Echinococcus granulosus	endophilin A3	0.0069	0.0274	0.0274
Brugia malayi	Variant SH3 domain containing protein	0.014	0.2207	0.6136
Trypanosoma cruzi	hypothetical protein, conserved	0.0069	0.0274	0.0858
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0069	0.0274	0.0274
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0069	0.0274	0.0274
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.014	0.2207	0.6136
Onchocerca volvulus		0.0091	0.0865	0.4026
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0274	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0069	0.0274	0.0858
Onchocerca volvulus		0.0091	0.0865	0.4026
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2149	0.5973
Echinococcus granulosus	tyrosine protein kinase Srms	0.0091	0.0865	0.0865
Schistosoma mansoni	suppressor of cytokine signaling	0.0071	0.0322	0.0397
Plasmodium vivax	vivapain-2	0.0059	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0071	0.0322	0.0397
Schistosoma mansoni	signal transduction protein lnk-related	0.0071	0.0322	0.0397
Brugia malayi	Spectrin alpha chain	0.0069	0.0274	0.0763
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0069	0.0274	0.1277
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0069	0.0274	0.0274
Schistosoma mansoni	hypothetical protein	0.0071	0.0322	0.0397
Echinococcus granulosus	cathepsin b	0.0176	0.3196	0.3196
Echinococcus granulosus	SHC transforming protein 3	0.0071	0.0322	0.0322
Trypanosoma brucei	conserved protein	0.0069	0.0274	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0122	0.1712	0.1712
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0069	0.0274	0.3172
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0274	0.0763
Echinococcus multilocularis	signal transduction protein lnk realted	0.0071	0.0322	0.0322
Loa Loa (eye worm)	p53BP2	0.0069	0.0274	0.0763
Entamoeba histolytica	hypothetical protein	0.0069	0.0274	0.3172
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0065	0.0158	0.5762
Echinococcus granulosus	tyrosine protein kinase Src42A	0.019	0.3597	0.3597

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.009 uM	Inhibitory activity against recombinant human cathepsin K	ChEMBL.	14684304
Ki (binding)	= 0.009 uM	Inhibitory activity against recombinant human cathepsin K	ChEMBL.	14684304
Ki (binding)	= 2.094 uM	Inhibitory activity against recombinant human cathepsin B	ChEMBL.	14684304
Ki (binding)	= 2.094 uM	Inhibitory activity against recombinant human cathepsin B	ChEMBL.	14684304
Ki (binding)	= 4.11 uM	Inhibitory activity against recombinant human cathepsin L	ChEMBL.	14684304
Ki (binding)	= 4.11 uM	Inhibitory activity against recombinant human cathepsin L	ChEMBL.	14684304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL353633

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 301721