Detailed information for compound 309846

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 289.35 | Formula: C16H21N2O3+
  • H donors: 2 H acceptors: 2 LogP: 1.51 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)O[C@@H]1CC2CCC([C@@H]1C(=O)N)[NH+]2C
  • InChi: 1S/C16H20N2O3/c1-18-11-7-8-12(18)14(15(17)19)13(9-11)21-16(20)10-5-3-2-4-6-10/h2-6,11-14H,7-9H2,1H3,(H2,17,19)/p+1/t11?,12?,13-,14+/m0/s1
  • InChiKey: LYAWGIUPISFTFF-CLRIEMFWSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0044 0.0287 0.0193
Brugia malayi sulfakinin receptor protein 0.0056 0.0411 0.0717
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Echinococcus multilocularis voltage dependent calcium channel 0.0084 0.0712 0.0712
Schistosoma mansoni biogenic amine (5HT) receptor 0.0307 0.3065 0.3776
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Loa Loa (eye worm) hypothetical protein 0.03 0.2997 0.5757
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0656 0.2345
Onchocerca volvulus 0.0056 0.0411 0.104
Loa Loa (eye worm) hypothetical protein 0.008 0.0666 0.1279
Schistosoma mansoni adenoreceptor 0.0056 0.0411 0.0353
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0411 0.0353
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0056 0.0411 0.104
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0044 0.0287 0.0287
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.015 0.1412 0.2461
Onchocerca volvulus 0.0044 0.0287 0.0725
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.008 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0411 0.0411
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0552
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0301
Onchocerca volvulus 0.0106 0.0942 0.2381
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0656 0.1634
Loa Loa (eye worm) hypothetical protein 0.0228 0.2236 0.4296
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.008 0.0666 0.0681
Onchocerca volvulus 0.008 0.0666 0.1682
Onchocerca volvulus 0.0106 0.0942 0.2381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Brugia malayi Melatonin receptor type 1A 0.0056 0.0411 0.0717
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0084 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0552
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0301
Schistosoma mansoni amine GPCR 0.06 0.6165 0.7774
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Toxoplasma gondii subtilisin SUB12 0.0032 0.0157 0.0665
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0411 0.079
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0411 0.0717
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Onchocerca volvulus 0.0031 0.0151 0.0382
Brugia malayi beta-lactamase family protein 0.0079 0.0656 0.1143
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0411 0.0411
Schistosoma mansoni hypothetical protein 0.0056 0.0411 0.0353
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1188 1
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Onchocerca volvulus 0.0032 0.0157 0.0396
Onchocerca volvulus 0.0106 0.0942 0.2381
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0056 0.0411 0.104
Schistosoma mansoni biogenic amine receptor 0.0056 0.0411 0.0353
Echinococcus multilocularis fibrillin 1 0.015 0.1412 0.1412
Loa Loa (eye worm) hypothetical protein 0.0307 0.3065 0.5888
Echinococcus granulosus g protein coupled receptor 0.0056 0.0411 0.0411
Schistosoma mansoni hypothetical protein 0.0044 0.0287 0.0193
Echinococcus granulosus g protein coupled receptor 0.0056 0.0411 0.0411
Echinococcus granulosus glycoprotein Antigen 5 0.008 0.0666 0.0666
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0656 0.126
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0414 0.4203 0.5244
Loa Loa (eye worm) hypothetical protein 0.0079 0.0656 0.126
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0084 0.0712 0.0712
Toxoplasma gondii microneme protein MIC17B 0.0032 0.0157 0.0665
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0411 0.104
Echinococcus granulosus voltage dependent calcium channel 0.0018 0.0009 0.0009
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0411 0.0411
Echinococcus multilocularis Tolloid protein 1 0.0194 0.1877 0.1877
Trichomonas vaginalis esterase, putative 0.0079 0.0656 0.1634
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0157 0.0665
Onchocerca volvulus 0.0056 0.0411 0.104
Loa Loa (eye worm) hypothetical protein 0.0391 0.3958 0.7604
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0656 0.1891
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0106 0.0942 0.181
Echinococcus multilocularis serotonin transporter 0.0391 0.3958 0.3958
Loa Loa (eye worm) hypothetical protein 0.008 0.0666 0.1279
Brugia malayi hypothetical protein 0.0106 0.0942 0.1642
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0411 0.0411
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Loa Loa (eye worm) hypothetical protein 0.015 0.1412 0.2713
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0411 0.0411
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0411 0.0717
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0066 0.0524 0.2315
Echinococcus multilocularis sodium channel protein 0.0036 0.02 0.02
Echinococcus granulosus fmrfamide receptor 0.0056 0.0411 0.0411
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0066 0.0524 0.2315
Onchocerca volvulus 0.0032 0.0157 0.0396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0346 0.0346
Echinococcus multilocularis tissue type plasminogen activator 0.0228 0.2236 0.2236
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0552
Brugia malayi Trypsin family protein 0.008 0.0666 0.116
Echinococcus granulosus cubilin 0.0044 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0106 0.0942 0.181
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Loa Loa (eye worm) hypothetical protein 0.015 0.1412 0.2713
Brugia malayi G-protein coupled receptor 0.0056 0.0411 0.0717
Loa Loa (eye worm) hypothetical protein 0.0123 0.112 0.2152
Brugia malayi neuropeptide F receptor 0.0056 0.0411 0.0717
Onchocerca volvulus 0.0032 0.0157 0.0396
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0084 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0301
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Mycobacterium ulcerans hypothetical protein 0.008 0.0666 0.0186
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0138 0.024
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.1229 0.236
Echinococcus multilocularis sodium and chloride dependent glycine 0.0066 0.0524 0.0524
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0411 0.0411
Onchocerca volvulus Putative cubilin 0.0061 0.0465 0.1174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.1188 0.3367
Brugia malayi Nematode astacin protease protein 30 0.0044 0.0287 0.05
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0411 0.0353
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0411 0.0411
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0066 0.0524 0.0499
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0411 0.0411
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.0411 0.079
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0411 0.079
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0066 0.0524 0.0524
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0656 0.5
Toxoplasma gondii kringle domain-containing protein 0.0228 0.2236 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.015 0.1412 0.2713
Echinococcus granulosus microtubule associated protein 2 0.0763 0.789 0.789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0066 0.0524 0.1007
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0066 0.0524 0.0499
Echinococcus granulosus lamin 0.003 0.0138 0.0138
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0656 0.0668
Onchocerca volvulus 0.0032 0.0157 0.0396
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0411 0.0717
Loa Loa (eye worm) solute carrier family 6 member 4 0.0391 0.3958 0.7604
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.008 0.0666 0.0681
Echinococcus multilocularis cpg binding protein 0.0033 0.017 0.017
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0157 0.0665
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0291 0.2895 0.7313
Loa Loa (eye worm) norepinephrine transporter 0.0391 0.3958 0.7604
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Toxoplasma gondii rhoptry neck protein RON1 0.0106 0.0942 0.4192
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0066 0.0524 0.0499
Onchocerca volvulus 0.0056 0.0411 0.104
Echinococcus granulosus biogenic amine 5HT receptor 0.0307 0.3065 0.3065
Onchocerca volvulus 0.0044 0.0287 0.0725
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni opsin-like receptor 0.0056 0.0411 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0172 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0056 0.0411 0.104
Onchocerca volvulus 0.0044 0.0287 0.0725
Onchocerca volvulus 0.0257 0.2544 0.6427
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Brugia malayi G protein-coupled receptor 0.0056 0.0411 0.0717
Plasmodium vivax apical sushi protein, putative 0.0106 0.0942 0.3734
Brugia malayi Dopamine receptor protein 1 0.0509 0.5206 0.9072
Treponema pallidum sodium- and chloride- dependent transporter 0.0391 0.3958 0.5
Loa Loa (eye worm) hypothetical protein 0.0194 0.1877 0.3606
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0084 0.0712 0.0742
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0411 0.0411
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0391 0.3958 0.6898
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Onchocerca volvulus 0.0032 0.0157 0.0396
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0552
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0066 0.0524 0.1007
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0172 0.0044
Loa Loa (eye worm) hypothetical protein 0.0066 0.0524 0.1007
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0411 0.104
Echinococcus multilocularis CUB 0.0044 0.0287 0.0287
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0157 0.0301
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0656 0.1634
Schistosoma mansoni hypothetical protein 0.0044 0.0287 0.0193
Echinococcus multilocularis lamin dm0 0.003 0.0138 0.0138
Loa Loa (eye worm) CUB domain-containing protein 0.0044 0.0287 0.0552
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Onchocerca volvulus 0.003 0.0138 0.0348
Trypanosoma cruzi hypothetical protein, conserved 0.0228 0.2236 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0066 0.0524 0.0914
Loa Loa (eye worm) intermediate filament protein 0.003 0.0138 0.0264
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Leishmania major hypothetical protein, conserved 0.0228 0.2236 1
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0411 0.0411
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Onchocerca volvulus 0.0032 0.0157 0.0396
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0172 0.0731
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0066 0.0524 0.0499
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0066 0.0524 0.0914
Loa Loa (eye worm) hypothetical protein 0.008 0.0666 0.1279
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.1188 0.1355
Brugia malayi hypothetical protein 0.0106 0.0942 0.1642
Brugia malayi Lectin C-type domain containing protein 0.0044 0.0287 0.05
Brugia malayi beta-lactamase 0.0079 0.0656 0.1143
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni opsin-like receptor 0.0056 0.0411 0.0353
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0411 0.079
Brugia malayi Pre-SET motif family protein 0.0033 0.0172 0.0299
Loa Loa (eye worm) hypothetical protein 0.0066 0.0524 0.1007
Onchocerca volvulus 0.003 0.0138 0.0348
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0032 0.0157 0.0665
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0411 0.0411
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0411 0.0411
Toxoplasma gondii hypothetical protein 0.0032 0.0157 0.0665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Brugia malayi larval opioid receptor 0.0056 0.0411 0.0717
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.008 0.0666 0.0666
Brugia malayi CXXC zinc finger family protein 0.0031 0.0151 0.0264
Schistosoma mansoni amine GPCR 0.0056 0.0411 0.0353
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.037 0.3738 0.718
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Brugia malayi CUB domain containing protein 0.0044 0.0287 0.05
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0151 0.0291
Onchocerca volvulus 0.0079 0.0656 0.1657
Mycobacterium leprae Probable lipase LipE 0.0079 0.0656 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0411 0.0717
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0172 0.0044
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0411 0.0411
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0533 0.051
Schistosoma mansoni hypothetical protein 0.0044 0.0287 0.0193
Toxoplasma gondii microneme protein MIC17A 0.0032 0.0157 0.0665
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus granulosus laminin 0.015 0.1412 0.1412
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0084 0.0712 0.0712
Echinococcus multilocularis sex peptide receptor 0.0056 0.0411 0.0411
Brugia malayi CUB domain containing protein 0.0044 0.0287 0.05
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0346 0.0346
Onchocerca volvulus 0.0106 0.0942 0.2381
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0411 0.0353
Schistosoma mansoni hypothetical protein 0.0443 0.4509 0.5639
Loa Loa (eye worm) CUB domain-containing protein 0.0044 0.0287 0.0552
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0411 0.0353
Brugia malayi hypothetical protein 0.0106 0.0942 0.1642
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0411 0.0411
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0346 0.0269
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni hypothetical protein 0.0056 0.0411 0.0353
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0411 0.0353
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0084 0.0712 0.0712
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0411 0.079
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Schistosoma mansoni cpg binding protein 0.0033 0.017 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0411 0.0353
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0066 0.0524 0.0914
Schistosoma mansoni sodium-dependent amino acid transporter 0.0066 0.0524 0.0499
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Brugia malayi hypothetical protein 0.0106 0.0942 0.1642
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0346 0.0665
Loa Loa (eye worm) hypothetical protein 0.0106 0.0942 0.181
Plasmodium vivax amine transporter, putative 0.0066 0.0524 0.1709
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Echinococcus granulosus intermediate filament protein 0.003 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus multilocularis cubilin 0.0044 0.0287 0.0287
Brugia malayi Calcium binding EGF domain containing protein 0.0061 0.0465 0.081
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0056 0.0411 0.104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0411 0.0411
Loa Loa (eye worm) beta-lactamase 0.0079 0.0656 0.126
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0036 0.02 0.02
Onchocerca volvulus 0.0228 0.2236 0.565
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Loa Loa (eye worm) hypothetical protein 0.0066 0.0524 0.1007
Toxoplasma gondii calcium binding egf domain-containing protein 0.015 0.1412 0.63
Onchocerca volvulus 0.0066 0.0524 0.1325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Loa Loa (eye worm) hypothetical protein 0.0066 0.0524 0.1007
Onchocerca volvulus 0.008 0.0666 0.1682
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0411 0.0353
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0411 0.0411
Echinococcus granulosus lamin dm0 0.003 0.0138 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0346 0.0269
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0411 0.0411
Schistosoma mansoni neuropeptide receptor 0.0056 0.0411 0.0353
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Schistosoma mansoni hypothetical protein 0.0056 0.0411 0.0353
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0411 0.0353
Echinococcus granulosus c4b binding protein beta chain 0.0106 0.0942 0.0942
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0346 0.0604
Echinococcus granulosus serotonin transporter 0.0391 0.3958 0.3958
Brugia malayi MH2 domain containing protein 0.0133 0.1229 0.2141
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.008 0.0666 0.0681
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0552
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0411 0.0717
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Onchocerca volvulus 0.0032 0.0157 0.0396
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0044 0.0287 0.05
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0106 0.0942 0.181
Brugia malayi pregnancy-associated plasma protein-A 0.0106 0.0942 0.1642
Echinococcus multilocularis somatostatin receptor 0.0056 0.0411 0.0411
Echinococcus granulosus dnaJ subfamily B 0.0443 0.4509 0.4509
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0301
Onchocerca volvulus 0.0079 0.0656 0.1657
Echinococcus multilocularis musashi 0.003 0.0138 0.0138
Brugia malayi CUB domain containing protein 0.0044 0.0287 0.05
Echinococcus multilocularis glycoprotein Antigen 5 0.008 0.0666 0.0666
Schistosoma mansoni hypothetical protein 0.008 0.0666 0.0681
Echinococcus multilocularis c4b binding protein beta chain 0.0106 0.0942 0.0942
Echinococcus multilocularis enteropeptidase 0.008 0.0666 0.0666
Brugia malayi Fibulin-1 precursor 0.015 0.1412 0.2461
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0411 0.0411
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0106 0.0942 0.2381
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0044 0.0287 0.0552
Schistosoma mansoni sodium/chloride dependent transporter 0.0066 0.0524 0.0499
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0044 0.0287 0.0552
Loa Loa (eye worm) hypothetical protein 0.0066 0.0524 0.1007
Brugia malayi Dopamine receptor protein 2 0.0056 0.0411 0.0717
Trichomonas vaginalis set domain proteins, putative 0.0257 0.2544 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.1188 0.5294
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni microtubule-associated protein tau 0.0763 0.789 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0411 0.0717
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Loa Loa (eye worm) hypothetical protein 0.0079 0.0656 0.126
Echinococcus granulosus sex peptide receptor 0.0056 0.0411 0.0411
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0157 0.0665
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0301
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0411 0.0411
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0066 0.0524 0.5
Schistosoma mansoni hypothetical protein 0.0228 0.2236 0.2707
Brugia malayi G-protein coupled receptor 0.0056 0.0411 0.0717
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0056 0.0411 0.104
Brugia malayi hypothetical protein 0.008 0.0666 0.116
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0017
Brugia malayi Pre-SET motif family protein 0.0226 0.2214 0.3859
Loa Loa (eye worm) hypothetical protein 0.0061 0.0465 0.0893
Onchocerca volvulus 0.0066 0.0524 0.1325
Schistosoma mansoni hypothetical protein 0.008 0.0666 0.0681
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0411 0.0411
Loa Loa (eye worm) calcium channel 0.0084 0.0712 0.1369
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0411 0.079
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0391 0.3958 0.4928
Loa Loa (eye worm) serotonin transporter b 0.0391 0.3958 0.7604
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus multilocularis voltage dependent calcium channel 0.0084 0.0712 0.0712
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.1188 0.1355
Onchocerca volvulus 0.008 0.0666 0.1682
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0056 0.0411 0.104
Brugia malayi Nematode astacin protease protein 30 0.0044 0.0287 0.05
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0458 0.2019
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0411 0.0353
Onchocerca volvulus 0.0056 0.0411 0.104
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus multilocularis C type lectin domian containing protein 0.0106 0.0942 0.0942
Loa Loa (eye worm) TK/ROR protein kinase 0.0228 0.2236 0.4296
Brugia malayi hypothetical protein 0.0066 0.0524 0.0914
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.1188 0.1188
Echinococcus granulosus cpg binding protein 0.0033 0.017 0.017
Brugia malayi AKH receptor 0.0056 0.0411 0.0717
Brugia malayi ORL1-like opioid receptor 0.0056 0.0411 0.0717
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.2214 0.4254
Echinococcus multilocularis Mastin 0.008 0.0666 0.0666
Schistosoma mansoni sodium/chloride dependent transporter 0.0391 0.3958 0.4928
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0051 0.0364 0.208
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0066 0.0524 0.0524
Brugia malayi intermediate filament protein 0.003 0.0138 0.024
Brugia malayi Serotonin receptor 0.0056 0.0411 0.0717
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0044 0.0287 0.0193
Brugia malayi Kringle domain containing protein 0.0228 0.2236 0.3897
Onchocerca volvulus 0.0106 0.0942 0.2381
Loa Loa (eye worm) hypothetical protein 0.037 0.3738 0.718
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0411 0.0353
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0056 0.0411 0.104
Brugia malayi Trypsin-like protease protein 5 0.008 0.0666 0.116
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Loa Loa (eye worm) hypothetical protein 0.015 0.1412 0.2713
Loa Loa (eye worm) hypothetical protein 0.0079 0.0656 0.126
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0411 0.0353
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0656 0.1634
Echinococcus granulosus Mastin 0.008 0.0666 0.0666
Schistosoma mansoni biogenic amine receptor 0.0056 0.0411 0.0353
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0044 0.0287 0.0552
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0411 0.0411
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1188 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus multilocularis transmembrane protease serine 3 0.008 0.0666 0.0666
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0044 0.0287 0.05
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0411 0.0353
Echinococcus multilocularis serotonin receptor 0.0307 0.3065 0.3065
Echinococcus multilocularis dnaJ subfamily B 0.0443 0.4509 0.4509
Onchocerca volvulus 0.0106 0.0942 0.2381
Loa Loa (eye worm) hypothetical protein 0.0079 0.0656 0.126
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni voltage-gated cation channel 0.0084 0.0712 0.0742
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0411 0.0411
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.015 0.1412 0.2713
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.008 0.0666 0.0666
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0172 0.0044
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0106 0.0942 0.181
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0552
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0552
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0051 0.0364 0.0393
Echinococcus multilocularis laminin 0.015 0.1412 0.1412
Schistosoma mansoni biogenic amine receptor 0.0056 0.0411 0.0353
Echinococcus granulosus g protein coupled receptor 0.0056 0.0411 0.0411
Echinococcus granulosus C type lectin domian containing protein 0.0106 0.0942 0.0942
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0066 0.0524 0.0499
Brugia malayi neuropeptide F receptor 0.0056 0.0411 0.0717
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0172 0.0172
Onchocerca volvulus 0.0056 0.0411 0.104
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0066 0.0524 0.0524
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0194 0.1877 0.3606
Loa Loa (eye worm) hypothetical protein 0.0033 0.0172 0.033
Onchocerca volvulus 0.0032 0.0157 0.0396
Brugia malayi Sushi domain 0.0106 0.0942 0.1642
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.008 0.0666 0.0666
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1188 1
Loa Loa (eye worm) hypothetical protein 0.0391 0.3958 0.7604
Brugia malayi GCC2 and GCC3 family protein 0.0123 0.112 0.1952
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0411 0.0353
Onchocerca volvulus 0.008 0.0666 0.1682
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0411 0.0717
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0194 0.1877 0.2244
Onchocerca volvulus 0.0106 0.0942 0.2381
Toxoplasma gondii microneme protein MIC4 0.0032 0.0157 0.0665
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0138 0.0264
Schistosoma mansoni cpg binding protein 0.0033 0.017 0.0042
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0411 0.0411
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0157 0.0665
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.1229 0.236
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0106 0.0942 0.181
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0228 0.2236 1
Brugia malayi hypothetical protein 0.0106 0.0942 0.1642
Echinococcus granulosus allatostatin A receptor 0.0056 0.0411 0.0411
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0066 0.0524 0.0499
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0044 0.0287 0.05
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Schistosoma mansoni amine GPCR 0.0056 0.0411 0.0353
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0066 0.0524 0.0524
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0124 0.1131 0.1281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0411 0.0411
Echinococcus granulosus CUB 0.0044 0.0287 0.0287
Toxoplasma gondii calcium binding egf domain-containing protein 0.015 0.1412 0.63
Echinococcus granulosus neuropeptide receptor 0.0056 0.0411 0.0411
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0411 0.0411
Brugia malayi Dopamine receptor 0.0056 0.0411 0.0717
Onchocerca volvulus 0.0056 0.0411 0.104
Onchocerca volvulus 0.0106 0.0942 0.2381
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0656 0.0656
Echinococcus granulosus cubilin 0.0044 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0411 0.0411
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0084 0.0712 0.0712
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0411 0.0411
Echinococcus granulosus sodium and chloride dependent glycine 0.0066 0.0524 0.0524
Echinococcus granulosus sodium and chloride dependent glycine 0.0066 0.0524 0.0524
Loa Loa (eye worm) hypothetical protein 0.003 0.0138 0.0264
Echinococcus multilocularis microtubule associated protein 2 0.0763 0.789 0.789
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0411 0.0353
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0411 0.0353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Loa Loa (eye worm) hypothetical protein 0.008 0.0666 0.1279
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Echinococcus granulosus transmembrane protease serine 3 0.008 0.0666 0.0666
Schistosoma mansoni cpg binding protein 0.0031 0.0151 0.0018
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0411 0.0411
Echinococcus granulosus serotonin receptor 0.0056 0.0411 0.0411
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0157 0.0665
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0157 0.0301
Brugia malayi Trypsin family protein 0.008 0.0666 0.116
Echinococcus multilocularis sodium and chloride dependent glycine 0.0066 0.0524 0.0524
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0411 0.0353
Brugia malayi CUB domain containing protein 0.0044 0.0287 0.05
Schistosoma mansoni amine GPCR 0.0056 0.0411 0.0353
Toxoplasma gondii rhoptry neck protein RON9 0.0106 0.0942 0.4192
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0066 0.0524 0.1007
Toxoplasma gondii microneme protein MIC17C 0.0032 0.0157 0.0665
Loa Loa (eye worm) hypothetical protein 0.0391 0.3958 0.7604
Echinococcus granulosus orexin receptor type 2 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Brugia malayi putative neuropeptide receptor 0.0056 0.0411 0.0717
Onchocerca volvulus 0.0033 0.0172 0.0433
Loa Loa (eye worm) hypothetical protein 0.0106 0.0942 0.181
Schistosoma mansoni opsin-like receptor 0.0056 0.0411 0.0353
Onchocerca volvulus 0.037 0.3738 0.9443
Onchocerca volvulus 0.0056 0.0411 0.104
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0066 0.0524 0.2315
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0411 0.0411
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0656 0.1634
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0504 0.5147 1
Schistosoma mansoni myosin xvIII 0.0056 0.0411 0.0353
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0656 1
Onchocerca volvulus 0.0056 0.0411 0.104
Brugia malayi Serotonin receptor 0.056 0.5738 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Brugia malayi Kelch motif family protein 0.0044 0.0287 0.05
Toxoplasma gondii hypothetical protein 0.0066 0.0524 0.2315
Echinococcus granulosus somatostatin receptor 0.0056 0.0411 0.0411
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0044 0.0287 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Echinococcus multilocularis serotonin receptor 0.0307 0.3065 0.3065
Plasmodium falciparum cysteine repeat modular protein 1 0.0228 0.2236 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0411 0.0411
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0411 0.0411
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0468 0.477 0.477
Loa Loa (eye worm) hypothetical protein 0.008 0.0666 0.1279
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0411 0.0411
Toxoplasma gondii hypothetical protein 0.0066 0.0524 0.2315
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0411 0.0353
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0411 0.0353
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0066 0.0524 0.0524
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0066 0.0524 0.0524
Echinococcus multilocularis lamin 0.003 0.0138 0.0138
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0963 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.015 0.1412 0.2461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0346 0.0346
Brugia malayi PAN domain containing protein 0.0032 0.0157 0.0273
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0301
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0301
Schistosoma mansoni amine GPCR 0.0056 0.0411 0.0353
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.008 0.0666 0.0681
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0656 0.1143
Onchocerca volvulus 0.0106 0.0942 0.2381
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0066 0.0524 0.1325
Onchocerca volvulus 0.0044 0.0287 0.0725
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0066 0.0524 0.0914
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0157 0.0301
Loa Loa (eye worm) hypothetical protein 0.0079 0.0656 0.126
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0172 0.0172
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0524 0.1709
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0411 0.0717
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0656 0.1891
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0411 0.0411
Echinococcus multilocularis cubilin 0.0044 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Toxoplasma gondii PAN domain-containing protein 0.0032 0.0157 0.0665
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0066 0.0524 0.0524
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0656 0.0656
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.008 0.0666 0.116
Brugia malayi CUB domain containing protein 0.0044 0.0287 0.05
Echinococcus granulosus enteropeptidase 0.008 0.0666 0.0666
Onchocerca volvulus Arrow homolog 0.015 0.1412 0.3568
Brugia malayi astacin protease protein 30 0.0044 0.0287 0.05
Brugia malayi Trypsin family protein 0.008 0.0666 0.116
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0084 0.0712 0.0712
Onchocerca volvulus 0.0056 0.0411 0.104
Schistosoma mansoni neuropeptide receptor 0.0056 0.0411 0.0353
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0066 0.0524 0.0499
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Brugia malayi hypothetical protein 0.0106 0.0942 0.1642
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.1188 0.1188
Echinococcus granulosus hypothetical protein 0.0056 0.0411 0.0411
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0411 0.0411
Schistosoma mansoni c4b-binding protein beta chain 0.0106 0.0942 0.1038
Brugia malayi hypothetical protein 0.0044 0.0287 0.05
Onchocerca volvulus 0.0032 0.0157 0.0396
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Schistosoma mansoni histamine h1 receptor 0.0056 0.0411 0.0353
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Loa Loa (eye worm) hypothetical protein 0.0106 0.0942 0.181
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0411 0.0411
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0084 0.0712 0.1242
Onchocerca volvulus 0.008 0.0666 0.1682
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0411 0.0411
Schistosoma mansoni hypothetical protein 0.0044 0.0287 0.0193
Echinococcus granulosus biogenic amine 5HT receptor 0.0468 0.477 0.477
Brugia malayi hypothetical protein 0.0106 0.0942 0.1642
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0056 0.0411 0.079
Brugia malayi beta-lactamase family protein 0.0079 0.0656 0.1143
Schistosoma mansoni cercarial elastase (S01 family) 0.008 0.0666 0.0681
Schistosoma mansoni hypothetical protein 0.0044 0.0287 0.0193
Onchocerca volvulus 0.0391 0.3958 1
Brugia malayi Protein kinase domain containing protein 0.0228 0.2236 0.3897
Brugia malayi GnHR receptor homolog 0.0056 0.0411 0.0717
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0411 0.0411
Brugia malayi RE15519p 0.0056 0.0411 0.0717
Loa Loa (eye worm) hypothetical protein 0.0079 0.0656 0.126
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0411 0.0411
Loa Loa (eye worm) DPY-31 protein 0.0044 0.0287 0.0552
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.1188 0.1185
Brugia malayi hypothetical protein 0.0056 0.0411 0.0717
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0056 0.0411 0.104
Loa Loa (eye worm) hypothetical protein 0.0307 0.3065 0.5888
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0411 0.0411
Onchocerca volvulus 0.0032 0.0157 0.0396
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0066 0.0524 0.0499
Loa Loa (eye worm) hypothetical protein 0.0066 0.0524 0.1007
Schistosoma mansoni neuropeptide receptor 0.0056 0.0411 0.0353
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0157 0.0301
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0084 0.0712 0.0742
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.037 0.3738 0.4644
Toxoplasma gondii ABC1 family protein 0.0079 0.0656 0.2905
Loa Loa (eye worm) hypothetical protein 0.0084 0.0712 0.1369
Loa Loa (eye worm) hypothetical protein 0.0509 0.5206 1
Onchocerca volvulus 0.0032 0.0157 0.0396
Schistosoma mansoni sodium/chloride dependent transporter 0.0066 0.0524 0.0499
Schistosoma mansoni egf-like domain protein 0.015 0.1412 0.1644
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0656 0.0668
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0656 0.1634
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0152 0.0152
Toxoplasma gondii microneme protein, putative 0.0032 0.0157 0.0665
Onchocerca volvulus 0.0079 0.0656 0.1657
Schistosoma mansoni biogenic amine (5HT) receptor 0.0468 0.477 0.5975
Echinococcus granulosus neuropeptide receptor 0.0056 0.0411 0.0411
Plasmodium falciparum apical sushi protein 0.0106 0.0942 0.2442
Brugia malayi follicle stimulating hormone receptor 0.0056 0.0411 0.0717
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0253
Toxoplasma gondii PAN/Apple domain-containing protein 0.0032 0.0157 0.0665
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0346 0.0269
Schistosoma mansoni neuropeptide receptor 0.0056 0.0411 0.0353
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0552
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.008 0.0666 0.0681
Echinococcus granulosus Tolloid protein 1 0.0194 0.1877 0.1877
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0411 0.0353
Loa Loa (eye worm) PAN domain-containing protein 0.0032 0.0157 0.0301
Toxoplasma gondii hypothetical protein 0.0032 0.0157 0.0665
Echinococcus granulosus voltage dependent calcium channel 0.0084 0.0712 0.0712
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0172 0.0172
Loa Loa (eye worm) trypsin family protein 0.008 0.0666 0.1279
Echinococcus granulosus tissue type plasminogen activator 0.0228 0.2236 0.2236
Brugia malayi Trypsin family protein 0.037 0.3738 0.6514
Schistosoma mansoni hypothetical protein 0.0056 0.0411 0.0353
Loa Loa (eye worm) voltage-dependent calcium channel 0.0018 0.0009 0.0017

Activities

Activity type Activity value Assay description Source Reference
RBA (binding) = 22 Binding affinity against human monoclonal antibody (mAb) 2E2 relative to cocaine by ELISA method. ChEMBL. 14695827

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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