TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 289.35 | Formula: C16H21N2O3+
H donors: 2 H acceptors: 2 LogP: 1.51 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)O[C@@H]1CC2CCC([C@@H]1C(=O)N)[NH+]2C
InChi: 1S/C16H20N2O3/c1-18-11-7-8-12(18)14(15(17)19)13(9-11)21-16(20)10-5-3-2-4-6-10/h2-6,11-14H,7-9H2,1H3,(H2,17,19)/p+1/t11?,12?,13-,14+/m0/s1
InChiKey: LYAWGIUPISFTFF-CLRIEMFWSA-O

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0056	0.0411	0.0353
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0504	0.5147	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0056	0.0411	0.0717
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0307	0.3065	0.5888
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0942	0.181
Onchocerca volvulus		0.0079	0.0656	0.1657
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0056	0.0411	0.079
Brugia malayi	follicle stimulating hormone receptor	0.0056	0.0411	0.0717
Brugia malayi	Kringle domain containing protein	0.0228	0.2236	0.3897
Echinococcus multilocularis	Tolloid protein 1	0.0194	0.1877	0.1877
Brugia malayi	GCC2 and GCC3 family protein	0.0123	0.112	0.1952
Brugia malayi	hypothetical protein	0.008	0.0666	0.116
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0066	0.0524	0.0524
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0129	0.1188	0.3367
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Echinococcus granulosus	7TM GPCR rhodopsin	0.0056	0.0411	0.0411
Brugia malayi	beta-lactamase family protein	0.0079	0.0656	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0194	0.1877	0.3606
Onchocerca volvulus		0.0106	0.0942	0.2381
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0056	0.0411	0.0411
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0414	0.4203	0.5244
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0524	0.1007
Echinococcus granulosus	voltage dependent calcium channel	0.0018	0.0009	0.0009
Echinococcus multilocularis	neuropeptides capa receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Toxoplasma gondii	microneme protein, putative	0.0032	0.0157	0.0665
Toxoplasma gondii	ABC1 family protein	0.0079	0.0656	0.2905
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.015	0.1412	0.2713
Onchocerca volvulus	Arrow homolog	0.015	0.1412	0.3568
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0084	0.0712	0.0712
Schistosoma mansoni	neuropeptide receptor	0.0056	0.0411	0.0353
Brugia malayi	neuropeptide F receptor	0.0056	0.0411	0.0717
Echinococcus multilocularis	tissue type plasminogen activator	0.0228	0.2236	0.2236
Echinococcus granulosus	fmrfamide receptor	0.0056	0.0411	0.0411
Onchocerca volvulus		0.0079	0.0656	0.1657
Loa Loa (eye worm)	MH2 domain-containing protein	0.0133	0.1229	0.236
Toxoplasma gondii	microneme protein MIC17B	0.0032	0.0157	0.0665
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.1188	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0468	0.477	0.5975
Onchocerca volvulus		0.0056	0.0411	0.104
Toxoplasma gondii	rhoptry neck protein RON1	0.0106	0.0942	0.4192
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0656	0.126
Loa Loa (eye worm)	lectin C-type domain-containing protein	0.0044	0.0287	0.0552
Loa Loa (eye worm)	CUB domain-containing protein	0.0044	0.0287	0.0552
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0151	0.0264
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0056	0.0411	0.0717
Brugia malayi	ORL1-like opioid receptor	0.0056	0.0411	0.0717
Plasmodium vivax	apical sushi protein, putative	0.0106	0.0942	0.3734
Brugia malayi	Serotonin receptor	0.0056	0.0411	0.0717
Leishmania major	hypothetical protein, conserved	0.0228	0.2236	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0056	0.0411	0.104
Onchocerca volvulus		0.0044	0.0287	0.0725
Schistosoma mansoni	hypothetical protein	0.008	0.0666	0.0681
Schistosoma mansoni	hypothetical protein	0.0056	0.0411	0.0353
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.0533	0.051
Echinococcus granulosus	beta LACTamase domain containing family member	0.0079	0.0656	0.0656
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0391	0.3958	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.0301
Echinococcus multilocularis	voltage dependent calcium channel	0.0084	0.0712	0.0712
Brugia malayi	CUB domain containing protein	0.0044	0.0287	0.05
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.0301
Brugia malayi	CUB domain containing protein	0.0044	0.0287	0.05
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Toxoplasma gondii	calcium binding egf domain-containing protein	0.015	0.1412	0.63
Brugia malayi	MH2 domain containing protein	0.0133	0.1229	0.2141
Echinococcus multilocularis	orexin receptor type 2	0.0056	0.0411	0.0411
Echinococcus multilocularis	C type lectin domian containing protein	0.0106	0.0942	0.0942
Echinococcus granulosus	voltage dependent calcium channel	0.0084	0.0712	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0066	0.0524	0.0524
Loa Loa (eye worm)	TYRA-2 protein	0.0056	0.0411	0.079
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0346	0.0604
Echinococcus granulosus	somatostatin receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	zinc metalloproteinase toh-2	0.0044	0.0287	0.0552
Echinococcus granulosus	biogenic amine 5HT receptor	0.0468	0.477	0.477
Brugia malayi	Pre-SET motif family protein	0.0226	0.2214	0.3859
Brugia malayi	CUB domain containing protein	0.0044	0.0287	0.05
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0391	0.3958	0.6898
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Onchocerca volvulus		0.0032	0.0157	0.0396
Onchocerca volvulus		0.0066	0.0524	0.1325
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0066	0.0524	0.0524
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0051	0.0364	0.0393
Onchocerca volvulus		0.0032	0.0157	0.0396
Loa Loa (eye worm)	hypothetical protein	0.008	0.0666	0.1279
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0157	0.0665
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.2214	0.4254
Echinococcus multilocularis	fibrillin 1	0.015	0.1412	0.1412
Brugia malayi	putative neuropeptide receptor NPR1	0.0056	0.0411	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0287	0.0552
Brugia malayi	Protein kinase domain containing protein	0.0228	0.2236	0.3897
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus granulosus	G protein coupled receptor 139	0.0056	0.0411	0.0411
Echinococcus granulosus	dro:myosuppressin receptor	0.0056	0.0411	0.0411
Onchocerca volvulus		0.008	0.0666	0.1682
Loa Loa (eye worm)	hypothetical protein	0.03	0.2997	0.5757
Echinococcus granulosus	C type lectin domian containing protein	0.0106	0.0942	0.0942
Schistosoma mansoni	neuropeptide F-like receptor	0.0056	0.0411	0.0353
Loa Loa (eye worm)	beta-lactamase	0.0079	0.0656	0.126
Onchocerca volvulus		0.0033	0.0172	0.0433
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.0411	0.0353
Echinococcus granulosus	transmembrane protease serine 3	0.008	0.0666	0.0666
Echinococcus granulosus	neuropeptide Y receptor	0.0056	0.0411	0.0411
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Loa Loa (eye worm)	hypothetical protein	0.015	0.1412	0.2713
Schistosoma mansoni	sodium/chloride dependent transporter	0.0066	0.0524	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0656	0.126
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0129	0.1188	0.1188
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0079	0.0656	0.126
Loa Loa (eye worm)	hypothetical protein	0.0228	0.2236	0.4296
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0172	0.0044
Schistosoma mansoni	neuropilin (nrp) and tolloid (tll)-like	0.0044	0.0287	0.0193
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0307	0.3065	0.3776
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0066	0.0524	0.0499
Echinococcus multilocularis	musashi	0.003	0.0138	0.0138
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0346	0.0346
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0056	0.0411	0.104
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.008	0.0666	0.0666
Onchocerca volvulus		0.037	0.3738	0.9443
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Trichomonas vaginalis	penicillin-binding protein, putative	0.0079	0.0656	0.1634
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Brugia malayi	Sushi domain	0.0106	0.0942	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0287	0.0552
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0066	0.0524	0.2315
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.015	0.1412	0.2461
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0942	0.181
Echinococcus granulosus	sodium and chloride dependent glycine	0.0066	0.0524	0.0524
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0346	0.0269
Onchocerca volvulus		0.0044	0.0287	0.0725
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.0411	0.0353
Echinococcus granulosus	tissue type plasminogen activator	0.0228	0.2236	0.2236
Loa Loa (eye worm)	transcription factor SMAD2	0.0133	0.1229	0.236
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.0656	0.1891
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0056	0.0411	0.0411
Brugia malayi	Dopamine receptor	0.0056	0.0411	0.0717
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0056	0.0411	0.0411
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Loa Loa (eye worm)	hypothetical protein	0.008	0.0666	0.1279
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0084	0.0712	0.0712
Echinococcus granulosus	neuropeptide Y receptor	0.0056	0.0411	0.0411
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0056	0.0411	0.0717
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.0411	0.0411
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Onchocerca volvulus	Putative cubilin	0.0061	0.0465	0.1174
Echinococcus granulosus	neuropeptides capa receptor	0.0056	0.0411	0.0411
Schistosoma mansoni	hypothetical protein	0.0044	0.0287	0.0193
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	calcium channel	0.0084	0.0712	0.1369
Onchocerca volvulus		0.0106	0.0942	0.2381
Loa Loa (eye worm)	hypothetical protein	0.008	0.0666	0.1279
Onchocerca volvulus		0.003	0.0138	0.0348
Brugia malayi	GnHR receptor homolog	0.0056	0.0411	0.0717
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0157	0.0301
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0056	0.0411	0.0353
Toxoplasma gondii	microneme protein MIC4	0.0032	0.0157	0.0665
Brugia malayi	Pre-SET motif family protein	0.0033	0.0172	0.0299
Loa Loa (eye worm)	hypothetical protein	0.015	0.1412	0.2713
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0129	0.1188	0.1185
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0172	0.0731
Echinococcus multilocularis	glycoprotein Antigen 5	0.008	0.0666	0.0666
Brugia malayi	intermediate filament protein	0.003	0.0138	0.024
Echinococcus multilocularis	cpg binding protein	0.0033	0.017	0.017
Echinococcus multilocularis	neuropeptide receptor A26	0.0056	0.0411	0.0411
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.0656	0.1634
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Brugia malayi	Nematode astacin protease protein 30	0.0044	0.0287	0.05
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0129	0.1188	0.1188
Onchocerca volvulus		0.0228	0.2236	0.565
Echinococcus multilocularis	cubilin	0.0044	0.0287	0.0287
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0391	0.3958	0.7604
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	neuropeptide f receptor 76f	0.0056	0.0411	0.0353
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0066	0.0524	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0018	0.0009	0.0017
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Schistosoma mansoni	biogenic amine receptor	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	amine GPCR	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Onchocerca volvulus		0.008	0.0666	0.1682
Schistosoma mansoni	hypothetical protein	0.0044	0.0287	0.0193
Echinococcus multilocularis	G protein coupled receptor 139	0.0056	0.0411	0.0411
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0056	0.0411	0.0411
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Schistosoma mansoni	neuropeptide receptor	0.0056	0.0411	0.0353
Onchocerca volvulus		0.0106	0.0942	0.2381
Echinococcus granulosus	laminin	0.015	0.1412	0.1412
Echinococcus multilocularis	dnaJ subfamily B	0.0443	0.4509	0.4509
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0056	0.0411	0.079
Onchocerca volvulus		0.0106	0.0942	0.2381
Onchocerca volvulus		0.0056	0.0411	0.104
Echinococcus multilocularis	Mastin	0.008	0.0666	0.0666
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0056	0.0411	0.0411
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0157	0.0665
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0157	0.0665
Onchocerca volvulus		0.008	0.0666	0.1682
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0051	0.0364	0.208
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus multilocularis	voltage dependent calcium channel	0.0084	0.0712	0.0712
Trichomonas vaginalis	set domain proteins, putative	0.0257	0.2544	1
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0032	0.0157	0.0665
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0056	0.0411	0.0411
Toxoplasma gondii	rhoptry neck protein RON9	0.0106	0.0942	0.4192
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus multilocularis	g-protein coupled receptor	0.0056	0.0411	0.0411
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.0656	0.1634
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.0411	0.0353
Schistosoma mansoni	egf-like domain protein	0.015	0.1412	0.1644
Echinococcus multilocularis	lamin dm0	0.003	0.0138	0.0138
Echinococcus granulosus	sex peptide receptor	0.0056	0.0411	0.0411
Trichomonas vaginalis	penicillin-binding protein, putative	0.0079	0.0656	0.1634
Brugia malayi	G protein-coupled receptor	0.0056	0.0411	0.0717
Brugia malayi	Calcium binding EGF domain containing protein	0.0061	0.0465	0.081
Echinococcus multilocularis	CUB	0.0044	0.0287	0.0287
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0056	0.0411	0.0411
Toxoplasma gondii	microneme protein MIC17A	0.0032	0.0157	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus granulosus	g protein coupled receptor	0.0056	0.0411	0.0411
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Echinococcus multilocularis	microtubule associated protein 2	0.0763	0.789	0.789
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0157	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0942	0.181
Schistosoma mansoni	hypothetical protein	0.0056	0.0411	0.0353
Loa Loa (eye worm)	melatonin receptor type 1A	0.0056	0.0411	0.079
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0066	0.0524	0.0524
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus multilocularis	laminin	0.015	0.1412	0.1412
Loa Loa (eye worm)	hypothetical protein	0.037	0.3738	0.718
Echinococcus granulosus	7tm_1 domain containing protein	0.0056	0.0411	0.0411
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.1188	1
Schistosoma mansoni	myosin xvIII	0.0056	0.0411	0.0353
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0032	0.0157	0.0665
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Trypanosoma cruzi	hypothetical protein, conserved	0.0228	0.2236	1
Onchocerca volvulus		0.0056	0.0411	0.104
Plasmodium falciparum	cysteine repeat modular protein 1	0.0228	0.2236	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.0301
Brugia malayi	hypothetical protein	0.0106	0.0942	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0656	0.126
Onchocerca volvulus		0.0032	0.0157	0.0396
Schistosoma mansoni	neuropeptide receptor	0.0056	0.0411	0.0353
Echinococcus granulosus	hypothetical protein	0.0056	0.0411	0.0411
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0157	0.0665
Echinococcus multilocularis	neuropeptide Y receptor	0.0056	0.0411	0.0411
Echinococcus granulosus	allatostatin A receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0056	0.0411	0.0411
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0066	0.0524	0.0524
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Onchocerca volvulus		0.0106	0.0942	0.2381
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0656	0.126
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0056	0.0411	0.0353
Onchocerca volvulus		0.0106	0.0942	0.2381
Schistosoma mansoni	sodium/chloride dependent transporter	0.0391	0.3958	0.4928
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.0656	0.1891
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0066	0.0524	0.0499
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0151	0.0291
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Schistosoma mansoni	hypothetical protein	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.037	0.3738	0.718
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0066	0.0524	0.0499
Schistosoma mansoni	aldehyde dehydrogenase	0.0129	0.1188	0.1355
Brugia malayi	sulfakinin receptor protein	0.0056	0.0411	0.0717
Toxoplasma gondii	microneme protein MIC17C	0.0032	0.0157	0.0665
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Loa Loa (eye worm)	hypothetical protein	0.0307	0.3065	0.5888
Brugia malayi	CUB domain containing protein	0.0044	0.0287	0.05
Schistosoma mansoni	sodium/chloride dependent transporter	0.0066	0.0524	0.0499
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.008	0.0666	0.0681
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0346	0.0665
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.008	0.0666	0.0666
Brugia malayi	RE15519p	0.0056	0.0411	0.0717
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0194	0.1877	0.3606
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.008	0.0666	0.0666
Echinococcus granulosus	neuropeptide FF receptor 2	0.0056	0.0411	0.0411
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0056	0.0411	0.0411
Echinococcus multilocularis	sex peptide receptor	0.0056	0.0411	0.0411
Toxoplasma gondii	aldehyde dehydrogenase	0.0129	0.1188	0.5294
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0132	0.0253
Brugia malayi	Kelch motif family protein	0.0044	0.0287	0.05
Schistosoma mansoni	amine GPCR	0.06	0.6165	0.7774
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0287	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	voltage-gated cation channel	0.0084	0.0712	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0524	0.1007
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Echinococcus granulosus	serotonin transporter	0.0391	0.3958	0.3958
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.008	0.0666	0.0681
Brugia malayi	hypothetical protein	0.0106	0.0942	0.1642
Toxoplasma gondii	hypothetical protein	0.0066	0.0524	0.2315
Echinococcus granulosus	biogenic amine 5HT receptor	0.0307	0.3065	0.3065
Onchocerca volvulus		0.0031	0.0151	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0656	0.126
Brugia malayi	hypothetical protein	0.0106	0.0942	0.1642
Schistosoma mansoni	hypothetical protein	0.0443	0.4509	0.5639
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0056	0.0411	0.0717
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.0656	0.1634
Loa Loa (eye worm)	hypothetical protein	0.0391	0.3958	0.7604
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0066	0.0524	0.1007
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0056	0.0411	0.0411
Echinococcus multilocularis	serotonin receptor	0.0307	0.3065	0.3065
Echinococcus granulosus	tm gpcr rhodopsin	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0287	0.0552
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0066	0.0524	0.1007
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0524	0.1007
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0056	0.0411	0.079
Brugia malayi	hypothetical protein	0.0106	0.0942	0.1642
Echinococcus granulosus	serotonin receptor	0.0056	0.0411	0.0411
Echinococcus granulosus	orexin receptor type 2	0.0056	0.0411	0.0411
Onchocerca volvulus		0.008	0.0666	0.1682
Brugia malayi	Suppressor of lurcher protein 1 precursor	0.0044	0.0287	0.05
Echinococcus multilocularis	neuropeptide receptor	0.0056	0.0411	0.0411
Onchocerca volvulus		0.0106	0.0942	0.2381
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0066	0.0524	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0056	0.0411	0.0411
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0056	0.0411	0.0717
Brugia malayi	beta-lactamase	0.0079	0.0656	0.1143
Onchocerca volvulus		0.0056	0.0411	0.104
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0465	0.0893
Schistosoma mansoni	c4b-binding protein beta chain	0.0106	0.0942	0.1038
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0524	0.1007
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	neuropeptide F-like receptor	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0391	0.3958	0.7604
Brugia malayi	hypothetical protein	0.0044	0.0287	0.05
Echinococcus multilocularis	transmembrane protease serine 3	0.008	0.0666	0.0666
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0056	0.0411	0.079
Onchocerca volvulus		0.0044	0.0287	0.0725
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0157	0.0301
Schistosoma mansoni	histamine h1 receptor	0.0056	0.0411	0.0353
Onchocerca volvulus		0.0044	0.0287	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0391	0.3958	0.7604
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0157	0.0301
Schistosoma mansoni	hypothetical protein	0.008	0.0666	0.0681
Loa Loa (eye worm)	G-protein coupled receptor	0.0056	0.0411	0.079
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Brugia malayi	Calcium binding EGF domain containing protein	0.015	0.1412	0.2461
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0056	0.0411	0.0353
Echinococcus multilocularis	neuropeptide s receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	neuropeptide F receptor	0.0056	0.0411	0.079
Brugia malayi	Serotonin receptor	0.056	0.5738	1
Onchocerca volvulus		0.0032	0.0157	0.0396
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Brugia malayi	Fibulin-1 precursor	0.015	0.1412	0.2461
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0056	0.0411	0.0411
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0066	0.0524	0.0499
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0066	0.0524	0.0524
Loa Loa (eye worm)	TK/ROR protein kinase	0.0228	0.2236	0.4296
Brugia malayi	Dopamine receptor protein 2	0.0056	0.0411	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0524	0.1007
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0056	0.0411	0.0353
Onchocerca volvulus		0.0056	0.0411	0.104
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.008	0.0666	0.0681
Onchocerca volvulus		0.0032	0.0157	0.0396
Brugia malayi	CUB domain containing protein	0.0044	0.0287	0.05
Schistosoma mansoni	biogenic amine receptor	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0509	0.5206	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0172	0.0172
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.008	0.0666	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus multilocularis	enteropeptidase	0.008	0.0666	0.0666
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0079	0.0656	0.0668
Brugia malayi	Trypsin family protein	0.008	0.0666	0.116
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0066	0.0524	0.0914
Toxoplasma gondii	hypothetical protein	0.0032	0.0157	0.0665
Loa Loa (eye worm)	neuropeptide F receptor	0.0056	0.0411	0.079
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0152	0.0152
Echinococcus multilocularis	neuropeptide receptor	0.0056	0.0411	0.0411
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0194	0.1877	0.2244
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0084	0.0712	0.1242
Onchocerca volvulus		0.0032	0.0157	0.0396
Onchocerca volvulus		0.0056	0.0411	0.104
Brugia malayi	hypothetical protein	0.0106	0.0942	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Onchocerca volvulus		0.0032	0.0157	0.0396
Plasmodium vivax	amine transporter, putative	0.0066	0.0524	0.1709
Brugia malayi	Dopamine receptor protein 1	0.0509	0.5206	0.9072
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0084	0.0712	0.0712
Schistosoma mansoni	cpg binding protein	0.0033	0.017	0.0042
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0056	0.0411	0.0411
Brugia malayi	putative neuropeptide receptor	0.0056	0.0411	0.0717
Plasmodium falciparum	apical sushi protein	0.0106	0.0942	0.2442
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.037	0.3738	0.4644
Echinococcus granulosus	dnaJ subfamily B	0.0443	0.4509	0.4509
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Onchocerca volvulus		0.0106	0.0942	0.2381
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0084	0.0712	0.0712
Echinococcus granulosus	g-protein coupled receptor	0.0056	0.0411	0.0411
Mycobacterium leprae	Probable lipase LipE	0.0079	0.0656	0.5
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0138	0.0264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0066	0.0524	0.0524
Echinococcus multilocularis	cubilin	0.0044	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0524	0.1007
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0079	0.0656	0.1143
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0079	0.0656	0.0656
Echinococcus multilocularis	lamin	0.003	0.0138	0.0138
Brugia malayi	Trypsin family protein	0.008	0.0666	0.116
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0124	0.1131	0.1281
Toxoplasma gondii	calcium binding egf domain-containing protein	0.015	0.1412	0.63
Toxoplasma gondii	subtilisin SUB12	0.0032	0.0157	0.0665
Echinococcus granulosus	c4b binding protein beta chain	0.0106	0.0942	0.0942
Onchocerca volvulus		0.0257	0.2544	0.6427
Echinococcus multilocularis	c4b binding protein beta chain	0.0106	0.0942	0.0942
Echinococcus granulosus	Tolloid protein 1	0.0194	0.1877	0.1877
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0066	0.0524	0.2315
Echinococcus multilocularis	serotonin receptor	0.0307	0.3065	0.3065
Echinococcus granulosus	glycoprotein Antigen 5	0.008	0.0666	0.0666
Loa Loa (eye worm)	hypothetical protein	0.015	0.1412	0.2713
Echinococcus granulosus	neuropeptide receptor	0.0056	0.0411	0.0411
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Onchocerca volvulus		0.0056	0.0411	0.104
Toxoplasma gondii	hypothetical protein	0.0066	0.0524	0.2315
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0287	0.0552
Echinococcus multilocularis	dro:myosuppressin receptor	0.0056	0.0411	0.0411
Brugia malayi	hypothetical protein	0.0066	0.0524	0.0914
Onchocerca volvulus		0.0079	0.0656	0.1657
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0287	0.0552
Loa Loa (eye worm)	DPY-31 protein	0.0044	0.0287	0.0552
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0056	0.0411	0.0353
Onchocerca volvulus		0.0106	0.0942	0.2381
Brugia malayi	AKH receptor	0.0056	0.0411	0.0717
Plasmodium vivax	hypothetical protein, conserved	0.0079	0.0656	0.2345
Onchocerca volvulus		0.0056	0.0411	0.104
Echinococcus granulosus	neuropeptide receptor A26	0.0056	0.0411	0.0411
Onchocerca volvulus		0.0391	0.3958	1
Echinococcus granulosus	g protein coupled receptor	0.0056	0.0411	0.0411
Brugia malayi	hypothetical protein	0.0106	0.0942	0.1642
Echinococcus granulosus	lamin dm0	0.003	0.0138	0.0138
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0172	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.0301
Echinococcus multilocularis	serotonin transporter	0.0391	0.3958	0.3958
Brugia malayi	zinc metalloproteinase toh-2 precursor	0.0044	0.0287	0.05
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0084	0.0712	0.0742
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0066	0.0524	0.0499
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0084	0.0712	0.0712
Echinococcus multilocularis	fmrfamide receptor	0.0056	0.0411	0.0411
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0084	0.0712	0.0712
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.0524	0.1709
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0056	0.0411	0.0411
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0056	0.0411	0.0353
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0138	0.0264
Schistosoma mansoni	opsin-like receptor	0.0056	0.0411	0.0353
Echinococcus granulosus	lamin	0.003	0.0138	0.0138
Echinococcus granulosus	Mastin	0.008	0.0666	0.0666
Echinococcus granulosus	neuropilin nrp and tolloid tll	0.0044	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.0301
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0066	0.0524	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0172	0.033
Onchocerca volvulus		0.0056	0.0411	0.104
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	microtubule-associated protein tau	0.0763	0.789	1
Echinococcus granulosus	neuropeptide s receptor	0.0056	0.0411	0.0411
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0963	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0079	0.0656	0.0668
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Echinococcus multilocularis	neuropeptides capa receptor	0.0056	0.0411	0.0411
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0712	0.1369
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0056	0.0411	0.0353
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.015	0.1412	0.2713
Echinococcus granulosus	CUB	0.0044	0.0287	0.0287
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Onchocerca volvulus		0.0056	0.0411	0.104
Brugia malayi	Zinc metalloproteinase toh-2 precursor	0.0044	0.0287	0.05
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0287	0.0552
Schistosoma mansoni	hypothetical protein	0.0056	0.0411	0.0353
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0106	0.0942	0.181
Schistosoma mansoni	hypothetical protein	0.0044	0.0287	0.0193
Onchocerca volvulus		0.0032	0.0157	0.0396
Onchocerca volvulus		0.0291	0.2895	0.7313
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0066	0.0524	0.0499
Onchocerca volvulus		0.0106	0.0942	0.2381
Echinococcus granulosus	sodium and chloride dependent glycine	0.0066	0.0524	0.0524
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0468	0.477	0.477
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0129	0.1188	1
Brugia malayi	neuropeptide F receptor	0.0056	0.0411	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0656	0.126
Onchocerca volvulus		0.0056	0.0411	0.104
Loa Loa (eye worm)	norepinephrine transporter	0.0391	0.3958	0.7604
Echinococcus multilocularis	allatostatin A receptor	0.0056	0.0411	0.0411
Onchocerca volvulus		0.0056	0.0411	0.104
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0056	0.0411	0.0717
Schistosoma mansoni	opsin-like receptor	0.0056	0.0411	0.0353
Schistosoma mansoni	growth hormone secretagogue receptor	0.0056	0.0411	0.0353
Brugia malayi	beta-lactamase family protein	0.0079	0.0656	0.1143
Brugia malayi	hypothetical protein	0.0106	0.0942	0.1642
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0084	0.0712	0.0712
Brugia malayi	Nematode astacin protease protein 30	0.0044	0.0287	0.05
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Mycobacterium ulcerans	hypothetical protein	0.008	0.0666	0.0186
Schistosoma mansoni	cercarial elastase (S01 family)	0.008	0.0666	0.0681
Onchocerca volvulus		0.0066	0.0524	0.1325
Trypanosoma brucei	hypothetical protein, conserved	0.0079	0.0656	1
Schistosoma mansoni	biogenic amine receptor	0.0056	0.0411	0.0353
Brugia malayi	Trypsin family protein	0.008	0.0666	0.116
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0346	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0066	0.0524	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0524	0.1007
Schistosoma mansoni	amine GPCR	0.0056	0.0411	0.0353
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0066	0.0524	0.0499
Onchocerca volvulus		0.0056	0.0411	0.104
Loa Loa (eye worm)	hypothetical protein	0.003	0.0138	0.0264
Trichomonas vaginalis	esterase, putative	0.0079	0.0656	0.1634
Schistosoma mansoni	opsin-like receptor	0.0056	0.0411	0.0353
Schistosoma mansoni	hypothetical protein	0.0044	0.0287	0.0193
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0157	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0942	0.181
Brugia malayi	Melatonin receptor type 1A	0.0056	0.0411	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0056	0.0411	0.0353
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0066	0.0524	0.0914
Toxoplasma gondii	kringle domain-containing protein	0.0228	0.2236	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0157	0.0301
Onchocerca volvulus		0.0066	0.0524	0.1325
Onchocerca volvulus		0.0056	0.0411	0.104
Schistosoma mansoni	adenoreceptor	0.0056	0.0411	0.0353
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0346	0.0269
Schistosoma mansoni	neuropilin (nrp) and tolloid (tll)-like	0.0044	0.0287	0.0193
Echinococcus multilocularis	fmrfamide receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	G-protein coupled receptor	0.0056	0.0411	0.079
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.008	0.0666	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.0301
Schistosoma mansoni	amine GPCR	0.0056	0.0411	0.0353
Brugia malayi	larval opioid receptor	0.0056	0.0411	0.0717
Brugia malayi	Trypsin family protein	0.037	0.3738	0.6514
Onchocerca volvulus		0.0032	0.0157	0.0396
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0172	0.0044
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0411	0.0411
Echinococcus granulosus	tm gpcr rhodopsin	0.0056	0.0411	0.0411
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0346	0.0346
Echinococcus granulosus	cubilin	0.0044	0.0287	0.0287
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0066	0.0524	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0056	0.0411	0.0411
Brugia malayi	astacin protease protein 30	0.0044	0.0287	0.05
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0066	0.0524	0.0524
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.008	0.0666	0.0681
Brugia malayi	Lectin C-type domain containing protein	0.0044	0.0287	0.05
Loa Loa (eye worm)	serotonin transporter b	0.0391	0.3958	0.7604
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Onchocerca volvulus		0.0032	0.0157	0.0396
Onchocerca volvulus		0.003	0.0138	0.0348
Onchocerca volvulus		0.008	0.0666	0.1682
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0172	0.0172
Brugia malayi	PAN domain containing protein	0.0032	0.0157	0.0273
Echinococcus granulosus	enteropeptidase	0.008	0.0666	0.0666
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.008	0.0666	0.1279
Echinococcus multilocularis	neuropilin (nrp) and tolloid (tll)	0.0044	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0942	0.181
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	hypothetical protein	0.0044	0.0287	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Toxoplasma gondii	hypothetical protein	0.0032	0.0157	0.0665
Onchocerca volvulus		0.0056	0.0411	0.104
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.0411	0.0411
Brugia malayi	G-protein coupled receptor	0.0056	0.0411	0.0717
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0056	0.0411	0.0353
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Echinococcus granulosus	neuropeptide receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus granulosus	neuropeptides capa receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus granulosus	cpg binding protein	0.0033	0.017	0.017
Echinococcus multilocularis	sodium channel protein	0.0036	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0287	0.0552
Onchocerca volvulus		0.0056	0.0411	0.104
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	CUB domain-containing protein	0.0044	0.0287	0.0552
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0066	0.0524	0.0914
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0036	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus granulosus	g protein coupled receptor	0.0056	0.0411	0.0411
Brugia malayi	hypothetical protein	0.0056	0.0411	0.0717
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0056	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0009	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0942	0.181
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0056	0.0411	0.0411
Loa Loa (eye worm)	trypsin family protein	0.008	0.0666	0.1279
Echinococcus multilocularis	neuropeptide Y receptor	0.0056	0.0411	0.0411
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0172	0.0044
Schistosoma mansoni	cpg binding protein	0.0033	0.017	0.0042
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0056	0.0411	0.079
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.008	0.0666	0.116
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Schistosoma mansoni	hypothetical protein	0.0228	0.2236	0.2707
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Echinococcus multilocularis	somatostatin receptor	0.0056	0.0411	0.0411
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0066	0.0524	0.2315
Schistosoma mansoni	aldehyde dehydrogenase	0.0129	0.1188	0.1355
Echinococcus granulosus	intermediate filament protein	0.003	0.0138	0.0138
Brugia malayi	pregnancy-associated plasma protein-A	0.0106	0.0942	0.1642
Brugia malayi	Trypsin-like protease protein 5	0.008	0.0666	0.116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0411	0.0353
Echinococcus granulosus	microtubule associated protein 2	0.0763	0.789	0.789
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0056	0.0411	0.0717
Schistosoma mansoni	cpg binding protein	0.0031	0.0151	0.0018
Schistosoma mansoni	neuropeptide receptor	0.0056	0.0411	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0942	0.181
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0044	0.0287	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0411	0.079
Treponema pallidum	sodium- and chloride- dependent transporter	0.0391	0.3958	0.5
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0228	0.2236	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.112	0.2152
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0138	0.024
Brugia malayi	G-protein coupled receptor	0.0056	0.0411	0.0717
Onchocerca volvulus		0.0056	0.0411	0.104
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0157	0.0301
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0157	0.0665
Echinococcus granulosus	cubilin	0.0044	0.0287	0.0287
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0084	0.0712	0.0742
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0458	0.2019
Loa Loa (eye worm)	hypothetical protein	0.008	0.0666	0.1279
Onchocerca volvulus		0.0032	0.0157	0.0396
Mycobacterium leprae	conserved hypothetical protein	0.0079	0.0656	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
RBA (binding)	= 22	Binding affinity against human monoclonal antibody (mAb) 2E2 relative to cocaine by ELISA method.	ChEMBL.	14695827

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 392024

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 309846