Detailed information for compound 310359

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.805 | Formula: C16H13ClN2O2S
  • H donors: 2 H acceptors: 3 LogP: 3.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C(=C(C(S2)C)C(=O)Nc1ccccn1)O
  • InChi: 1S/C16H13ClN2O2S/c1-9-14(16(21)19-13-4-2-3-7-18-13)15(20)11-8-10(17)5-6-12(11)22-9/h2-9,20H,1H3,(H,18,19,21)
  • InChiKey: SYAZNPMNIKVROG-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0121
Entamoeba histolytica cell division protein kinase 2, putative 0.0135 0.0779 0.2738
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.001 0.0033
Schistosoma mansoni hypothetical protein 0.0037 0.0173 0.0548
Plasmodium vivax protein kinase Crk2 0.0135 0.0779 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0313 0.1118
Echinococcus multilocularis cyclin k 0.0059 0.0313 0.0313
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0395 0.1253
Loa Loa (eye worm) hypothetical protein 0.0059 0.0313 0.1118
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0313 0.1118
Schistosoma mansoni hypothetical protein 0.052 0.3156 1
Schistosoma mansoni cyclin B 0.0463 0.2802 0.8878
Entamoeba histolytica hypothetical protein 0.0037 0.0173 0.0564
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0293 0.0993
Trypanosoma cruzi mitotic cyclin, putative 0.0059 0.0313 0.1068
Echinococcus multilocularis cyclin b3 0.0246 0.1467 0.1467
Entamoeba histolytica hypothetical protein 0.0183 0.1075 0.3802
Trichomonas vaginalis cyclin B, putative 0.0059 0.0313 0.1068
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0128 0.1166
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0183 0.1075 0.3802
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.001 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0293 0.0993
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0033 0.0302
Echinococcus granulosus cyclin B 0.0463 0.2802 0.8878
Trichomonas vaginalis cyclin D, putative 0.0246 0.1467 0.5209
Loa Loa (eye worm) CYL-1 protein 0.0059 0.0313 0.1118
Echinococcus multilocularis lamin 0.0027 0.0111 0.0111
Echinococcus multilocularis geminin 0.052 0.3156 0.3156
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0046 0.0108
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0361 0.0361
Entamoeba histolytica cyclin family protein 0.0246 0.1467 0.5209
Entamoeba histolytica protein kinase, putative 0.0183 0.1075 0.3802
Trichomonas vaginalis cyclins, putative 0.0463 0.2802 1
Schistosoma mansoni hypothetical protein 0.0059 0.0313 0.0993
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0086 0.0252
Echinococcus granulosus tar DNA binding protein 0.0067 0.0361 0.1143
Brugia malayi Cytochrome P450 family protein 0.0033 0.0149 0.0532
Loa Loa (eye worm) cyclin domain-containing protein 0.0059 0.0313 0.1118
Plasmodium falciparum cyclin 0.0246 0.1467 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0135 0.0779 0.7077
Schistosoma mansoni cyclin l 0.0059 0.0313 0.0993
Trypanosoma cruzi cdc2-related kinase 1 0.0135 0.0779 0.2738
Echinococcus granulosus hypothetical protein 0.0061 0.0324 0.1028
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0313 0.1068
Toxoplasma gondii hypothetical protein 0.0187 0.11 1
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0293 0.0927
Loa Loa (eye worm) hypothetical protein 0.0178 0.1047 0.3737
Brugia malayi Fli-1 protein 0.0217 0.1287 0.4593
Brugia malayi transcription factor E74 isoform 0.001 0.001 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0173 0.0548
Trichomonas vaginalis cyclin B3, putative 0.0246 0.1467 0.5209
Echinococcus multilocularis cyclin dependent kinase 0.0135 0.0779 0.0779
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0033 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0293 0.0993
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0313 0.1118
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0293 0.0927
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0033 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0128 0.0407
Echinococcus granulosus protein C ets 2 0.001 0.001 0.0033
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0059 0.0313 0.3749
Echinococcus granulosus cyclin b3 0.0246 0.1467 0.4648
Echinococcus granulosus Ankyrin 0.0014 0.0035 0.011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0046 0.0312
Echinococcus granulosus cyclins 0.0246 0.1467 0.4648
Brugia malayi Protein kinase domain containing protein 0.0019 0.0062 0.0221
Loa Loa (eye worm) hypothetical protein 0.0029 0.0128 0.0458
Leishmania major cytochrome p450-like protein 0.0014 0.0033 0.006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.1359 0.4849
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0313 0.1118
Brugia malayi Cyclin, N-terminal domain containing protein 0.0463 0.2802 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0046 0.0145
Echinococcus granulosus bloom syndrome protein 0.0021 0.0076 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0128 0.0407
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0046 0.0155
Entamoeba histolytica cyclin C, putative 0.0059 0.0313 0.1068
Entamoeba histolytica cell division protein kinase 2, putative 0.0135 0.0779 0.2738
Echinococcus multilocularis 0.0014 0.0033 0.0033
Treponema pallidum methylated-DNA-protein-cysteine S-methyltransferase (dat) 0.033 0.198 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0149 0.0532
Echinococcus granulosus death domain containing protein 0.0014 0.0034 0.0108
Giardia lamblia Hypothetical protein 0.0059 0.0313 0.1118
Entamoeba histolytica protein kinase, putative 0.0183 0.1075 0.3802
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0086 0.0252
Brugia malayi Uncoordinated protein 44 0.0014 0.0034 0.0121
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0059 0.0313 0.0993
Echinococcus granulosus geminin 0.052 0.3156 1
Leishmania major mitotic cyclin, putative 0.0059 0.0313 0.1068
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0086 0.0088
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.001 0.001
Giardia lamblia Kinase, CMGC CLK 0.0066 0.0352 0.1258
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0059 0.0313 0.0313
Echinococcus granulosus dual specificity 0.0183 0.1075 0.3407
Leishmania major cyclin 9, putative 0.0059 0.0313 0.1068
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.001 0.0037
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0034 0.0108
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0034 0.0121
Loa Loa (eye worm) hypothetical protein 0.0026 0.0108 0.0384
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0066 0.0352 0.1208
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1391 0.4935
Echinococcus granulosus dual specificity protein kinase clk2 0.0066 0.0352 0.1117
Schistosoma mansoni g1/s-specific cyclin C 0.0059 0.0313 0.0993
Trypanosoma brucei cyclin 9 0.0059 0.0313 0.1068
Brugia malayi Pre-SET motif family protein 0.0206 0.1215 0.4338
Trichomonas vaginalis cyclin B, putative 0.0463 0.2802 1
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0076 0.0273
Trypanosoma brucei cdc2-related kinase 1 0.0135 0.0779 0.2738
Brugia malayi hypothetical protein 0.0059 0.0313 0.1118
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0034 0.0034
Trichomonas vaginalis cyclins, putative 0.0463 0.2802 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0183 0.1075 0.3802
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0059 0.0313 0.0313
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0059 0.0313 0.2848
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0066 0.0352 0.1208
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0293 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0352 0.1117
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0293 0.0993
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0046 0.0108
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0122 0.0385
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0388 0.1384
Echinococcus multilocularis cyclins 0.0246 0.1467 0.1467
Loa Loa (eye worm) cyclin C 0.0059 0.0313 0.1118
Brugia malayi intermediate filament protein 0.0027 0.0111 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0313 0.1068
Echinococcus multilocularis cyclins 0.0246 0.1467 0.1467
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0128 0.0128
Echinococcus granulosus cyclins 0.0059 0.0313 0.0993
Echinococcus granulosus G2:mitotic specific cyclin B3 0.036 0.2168 0.6869
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.001 0.0033
Leishmania major cytochrome p450-like protein 0.0014 0.0033 0.006
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0361 0.1143
Echinococcus multilocularis dual specificity protein kinase clk2 0.0066 0.0352 0.0352
Trichomonas vaginalis cyclin B, putative 0.0463 0.2802 1
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0059 0.0313 0.1068
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0046 0.0417
Brugia malayi cytochrome P450 0.0014 0.0033 0.0116
Schistosoma mansoni hypothetical protein 0.0059 0.0313 0.0993
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0128 0.0407
Echinococcus granulosus cyclins 0.0246 0.1467 0.4648
Schistosoma mansoni cyclins 0.0246 0.1467 0.4648
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0313 0.1068
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0779 0.2467
Loa Loa (eye worm) hypothetical protein 0.0216 0.1281 0.4572
Entamoeba histolytica hypothetical protein 0.0037 0.0173 0.0564
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0293 0.1044
Schistosoma mansoni hypothetical protein 0.001 0.001 0.0033
Loa Loa (eye worm) RNA binding protein 0.0067 0.0361 0.1288
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0033 0.006
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0046 0.0108
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0046 0.0108
Brugia malayi Ets-domain containing protein 0.0072 0.0388 0.1384
Entamoeba histolytica cyclin family protein 0.0246 0.1467 0.5209
Schistosoma mansoni Cyclin fold protein 0.0059 0.0313 0.0993
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0124
Echinococcus granulosus lamin 0.0027 0.0111 0.0351
Onchocerca volvulus 0.0027 0.0111 0.0277
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0046 0.0046
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0034 0.0123
Trichomonas vaginalis cyclins, putative 0.0276 0.1648 0.5859
Echinococcus multilocularis cyclin y 0.0059 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0081
Trypanosoma brucei cdc2-related kinase 3 0.0135 0.0779 0.2738
Giardia lamblia G2/mitotic-specific cyclin B 0.0463 0.2802 1
Trichomonas vaginalis cyclin A, putative 0.0059 0.0313 0.1068
Echinococcus granulosus Cyclin L1 0.0059 0.0313 0.0993
Onchocerca volvulus Protein CNPPD1 homolog 0.0059 0.0313 0.1009
Trypanosoma brucei mitotic cyclin 0.0059 0.0313 0.1068
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0293 0.0993
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.001 0.0033
Leishmania major mitotic cyclin, putative 0.0059 0.0313 0.1068
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0066 0.0352 0.1208
Loa Loa (eye worm) cyclin domain-containing protein 0.0059 0.0313 0.1118
Plasmodium vivax SET domain protein, putative 0.0029 0.0128 0.1264
Trichomonas vaginalis cyclins, putative 0.0059 0.0313 0.1068
Trypanosoma cruzi cyclin 6, putative 0.0463 0.2802 1
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0034 0.0108
Mycobacterium tuberculosis Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra 0.1002 0.6129 1
Echinococcus granulosus cyclin t1 0.0059 0.0313 0.0993
Loa Loa (eye worm) cyclin domain-containing protein 0.0059 0.0313 0.1118
Trypanosoma cruzi CYC2-like cyclin, putative 0.0463 0.2802 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.001 0.001
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0076 0.0218
Entamoeba histolytica cyclin, domain containing protein 0.0059 0.0313 0.1068
Schistosoma mansoni cyclin k 0.0059 0.0313 0.0993
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0046 0.0046
Giardia lamblia Hypothetical protein 0.0059 0.0313 0.1118
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0033 0.006
Echinococcus granulosus cyclins 0.0246 0.1467 0.4648
Echinococcus multilocularis cyclins 0.0246 0.1467 0.1467
Echinococcus multilocularis cyclin dependent kinase 1 0.0135 0.0779 0.0779
Echinococcus granulosus cyclins 0.0246 0.1467 0.4648
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0779 0.2467
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.001 0.0033
Trichomonas vaginalis cyclin B, putative 0.0059 0.0313 0.1068
Trichomonas vaginalis cyclin B3, putative 0.0059 0.0313 0.1068
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0183 0.1075 0.3837
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.001 0.001
Trypanosoma cruzi cyclin, putative 0.0463 0.2802 1
Plasmodium vivax cyclin homologue, putative 0.0059 0.0313 0.3749
Brugia malayi cell division control protein 2 homolog 0.0135 0.0779 0.2779
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0066 0.0352 0.3204
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0293 0.0927
Echinococcus multilocularis Cyclin L1 0.0059 0.0313 0.0313
Schistosoma mansoni cyclin B3 0.036 0.2168 0.6869
Leishmania major protein kinase, putative 0.0066 0.0352 0.1208
Trichomonas vaginalis cyclin A, putative 0.0463 0.2802 1
Echinococcus granulosus lamin dm0 0.0027 0.0111 0.0351
Echinococcus multilocularis ets variant gene 4 0.001 0.001 0.001
Schistosoma mansoni ets 0.001 0.001 0.0033
Echinococcus granulosus cyclin y 0.0059 0.0313 0.0993
Toxoplasma gondii cyclin dependent kinase binding protein 0.0059 0.0313 0.2848
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0128 0.0407
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0034 0.0123
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0086 0.0307
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0388 0.0388
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0059 0.0313 0.0993
Entamoeba histolytica hypothetical protein 0.0037 0.0173 0.0564
Echinococcus granulosus cyclins 0.0246 0.1467 0.4648
Brugia malayi Ets-domain containing protein 0.0072 0.0388 0.1384
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0463 0.2802 1
Schistosoma mansoni ets-related 0.0217 0.1287 0.4078
Schistosoma mansoni cyclin d 0.0059 0.0313 0.0993
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0293 0.0993
Trypanosoma cruzi mitotic cyclin, putative 0.0059 0.0313 0.1068
Brugia malayi hypothetical protein 0.0037 0.0173 0.0617
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0111 0.0395
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0361 0.1288
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0313 0.1068
Echinococcus multilocularis cyclin y 0.0059 0.0313 0.0313
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.001 0.001
Echinococcus multilocularis cyclin dependent kinase 5 0.0135 0.0779 0.0779
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0313 0.1118
Loa Loa (eye worm) cyclin domain-containing protein 0.036 0.2168 0.7738
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.001 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0779 0.2738
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0173 0.0548
Plasmodium falciparum protein serine/threonine kinase-1 0.0066 0.0352 0.2402
Giardia lamblia Cyclin A 0.0246 0.1467 0.5236
Loa Loa (eye worm) D-ets-2 protein 0.001 0.001 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.1075 0.3407
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0034 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0313 0.3749
Brugia malayi Protein kinase domain containing protein 0.0066 0.0352 0.1258
Entamoeba histolytica protein kinase domain containing protein 0.0183 0.1075 0.3802
Echinococcus granulosus cyclin G2 0.0059 0.0313 0.0993
Echinococcus multilocularis cyclin 0.0059 0.0313 0.0313
Brugia malayi Protein kinase domain containing protein 0.0135 0.0779 0.2779
Schistosoma mansoni netrin receptor unc5 0.0014 0.0034 0.0108
Brugia malayi Ets-domain containing protein 0.001 0.001 0.0037
Echinococcus granulosus cyclin k 0.0059 0.0313 0.0993
Leishmania major cyclin 0.0463 0.2802 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0066 0.0352 0.4275
Echinococcus granulosus cyclin y 0.0059 0.0313 0.0993
Echinococcus granulosus cyclin G2 0.0059 0.0313 0.0993
Echinococcus multilocularis cyclin B 0.0463 0.2802 0.2802
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0066 0.0352 0.1208
Mycobacterium leprae PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA 0.1002 0.6129 1
Echinococcus granulosus cyclin A3 4 0.0059 0.0313 0.0993
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0046 0.0108
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0361 0.1288
Schistosoma mansoni gabp alpha 0.0072 0.0388 0.1229
Echinococcus multilocularis cyclin B3 1 0.0246 0.1467 0.1467
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0361 0.1143
Giardia lamblia Cyclin fold protein 1, putative 0.0059 0.0313 0.1118
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0779 0.2738
Mycobacterium ulcerans DNA-methyltransferase (modification methylase) 0.0134 0.0773 0.1215
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0293 0.2659
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0046 0.0046
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0313 0.1118
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0352 0.1208
Trichomonas vaginalis methylated-DNA--protein-cysteine methyltransferase, putative 0.033 0.198 0.7051
Loa Loa (eye worm) hypothetical protein 0.0059 0.0313 0.1118
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0037
Trichomonas vaginalis cyclins, putative 0.0463 0.2802 1
Brugia malayi hypothetical protein 0.0059 0.0313 0.1118
Trypanosoma cruzi cyclin 9, putative 0.0059 0.0313 0.1068
Brugia malayi Death domain containing protein 0.0014 0.0034 0.0121
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0046 0.0164
Echinococcus multilocularis protein C ets 2 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.001 0.001 0.0033
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0135 0.0779 0.2467
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0352 0.1117
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0066 0.0352 0.1208
Echinococcus multilocularis G1:S specific cyclin D1 0.0059 0.0313 0.0313
Brugia malayi RNA binding protein 0.0067 0.0361 0.1288
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.1467 0.5209
Loa Loa (eye worm) hypothetical protein 0.013 0.075 0.2678
Giardia lamblia Hypothetical protein 0.0246 0.1467 0.5236
Trichomonas vaginalis cyclin D, putative 0.0059 0.0313 0.1068
Brugia malayi Cytochrome P450 family protein 0.0023 0.0086 0.0307
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0361 0.1143
Trypanosoma brucei protein kinase, putative 0.0056 0.0293 0.0993
Trichomonas vaginalis cyclin B, putative 0.0463 0.2802 1
Onchocerca volvulus 0.0027 0.0111 0.0277
Echinococcus multilocularis Ankyrin 0.0014 0.0035 0.0035
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0046 0.0022
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0033 0.006
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0046 0.0164
Echinococcus multilocularis cyclin G2 0.0059 0.0313 0.0313
Leishmania major hypothetical protein, conserved 0.033 0.198 0.7051
Plasmodium falciparum protein kinase 5 0.0135 0.0779 0.5307
Brugia malayi Cyclin, N-terminal domain containing protein 0.0463 0.2802 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0135 0.0779 0.2738
Chlamydia trachomatis methylated-DNA protein-cysteine methyltransferase 0.033 0.198 0.5
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0034 0.0108
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0293 0.0993
Onchocerca volvulus Cyclin L homolog 0.0059 0.0313 0.1009
Onchocerca volvulus Cyclin L homolog 0.0059 0.0313 0.1009
Brugia malayi Cytochrome P450 family protein 0.0023 0.0086 0.0307
Echinococcus multilocularis cyclin A3 4 0.0059 0.0313 0.0313
Echinococcus multilocularis cyclin t1 0.0059 0.0313 0.0313
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.001 0.0037
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0066 0.0352 0.1208
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.001 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0313 0.1068
Plasmodium falciparum cyclin 1 0.0059 0.0313 0.2135
Trypanosoma brucei cyclin 3 0.0059 0.0313 0.1068
Brugia malayi cyclin fold protein 1 variant b 0.0059 0.0313 0.1118
Brugia malayi Cyclin, N-terminal domain containing protein 0.036 0.2168 0.7738
Brugia malayi hypothetical protein 0.012 0.0689 0.2457
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0293 0.0293
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.001 0.0033
Entamoeba histolytica hypothetical protein 0.0059 0.0313 0.1068
Echinococcus granulosus G1:S specific cyclin D1 0.0059 0.0313 0.0993
Echinococcus multilocularis cyclin G2 0.0059 0.0313 0.0313
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0046 0.0145
Schistosoma mansoni intermediate filament proteins 0.0027 0.0111 0.0351
Loa Loa (eye worm) hypothetical protein 0.0061 0.0324 0.1156
Trichomonas vaginalis cyclin B, putative 0.0246 0.1467 0.5209
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0033 0.006
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0395 0.0395
Trichomonas vaginalis cyclins, putative 0.0246 0.1467 0.5209
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0293 0.0993
Trypanosoma cruzi cdc2-related kinase 3 0.0135 0.0779 0.2738
Schistosoma mansoni ets-related 0.001 0.001 0.0033
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0026 0.0026
Leishmania major protein kinase, putative 0.0066 0.0352 0.1208
Brugia malayi Cyclin, N-terminal domain containing protein 0.0059 0.0313 0.1118
Brugia malayi MAP kinase sur-1 0.0056 0.0293 0.1044
Schistosoma mansoni lamin 0.0027 0.0111 0.0351
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0035 0.011
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0135 0.0779 0.2738
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0179
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0033 0.0103
Giardia lamblia Cyclin B-like protein 0.0059 0.0313 0.1118
Onchocerca volvulus 0.0463 0.2802 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0173 0.0173
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0293 0.0993
Echinococcus granulosus intermediate filament protein 0.0027 0.0111 0.0351
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0049 0.0155
Onchocerca volvulus 0.0234 0.1391 0.4904
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0076 0.0218
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0111 0.0395
Loa Loa (eye worm) cyclin domain-containing protein 0.0059 0.0313 0.1118
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0086 0.0307
Brugia malayi Protein kinase domain containing protein 0.0183 0.1075 0.3837
Loa Loa (eye worm) cytochrome P450 0.0014 0.0033 0.0116
Entamoeba histolytica cyclin, putative 0.0463 0.2802 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0128 0.0128
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.001 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0086 0.0307
Trypanosoma brucei mitotic cyclin 6 0.0463 0.2802 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.0395
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0293 0.1044
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0059 0.0313 0.1118
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0779 0.2738
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.033 0.198 0.7051
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0103
Loa Loa (eye worm) hypothetical protein 0.0313 0.1881 0.6713
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0361 0.1143
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0086 0.0252
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0135 0.0779 0.2779
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0046 0.0417
Brugia malayi Cyclin C 0.0059 0.0313 0.1118
Loa Loa (eye worm) fli-1 protein 0.0217 0.1287 0.4593
Echinococcus multilocularis dual specificity 0.0183 0.1075 0.1075
Loa Loa (eye worm) hypothetical protein 0.0061 0.0324 0.1158
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0293 0.0993
Schistosoma mansoni cytochrome P450 0.0014 0.0033 0.0103
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0128 0.0407
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0059 0.0313 0.2848
Loa Loa (eye worm) RecQ helicase 0.0021 0.0076 0.0273
Entamoeba histolytica hypothetical protein 0.0037 0.0173 0.0564
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0135 0.0779 0.2779
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0066 0.0352 0.1258
Loa Loa (eye worm) cyclin domain-containing protein 0.0059 0.0313 0.1118
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0059 0.0313 0.2135
Echinococcus multilocularis cyclins 0.0246 0.1467 0.1467
Brugia malayi isocitrate dehydrogenase 0.0016 0.0046 0.0164
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0388 0.1229
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0111 0.0395
Trichomonas vaginalis cyclin D, putative 0.0246 0.1467 0.5209
Schistosoma mansoni elf1 0.001 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.0463 0.2802 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0046 0.0046
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0076 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0293 0.0993
Schistosoma mansoni cyclin G 0.0059 0.0313 0.0993
Loa Loa (eye worm) hypothetical protein 0.0178 0.1047 0.3737
Brugia malayi TAR-binding protein 0.0067 0.0361 0.1288
Trichomonas vaginalis cyclin B, putative 0.0463 0.2802 1
Toxoplasma gondii cyclin 4, putative 0.0059 0.0313 0.2848
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0046 0.0046
Leishmania major cytochrome p450-like protein 0.0023 0.0086 0.0252
Trichomonas vaginalis cyclins, putative 0.0463 0.2802 1
Brugia malayi Cytochrome P450 family protein 0.0014 0.0033 0.0116
Entamoeba histolytica cyclin, putative 0.0246 0.1467 0.5209
Echinococcus granulosus cyclin dependent kinase 0.0135 0.0779 0.2467
Trichomonas vaginalis cyclins, putative 0.0059 0.0313 0.1068
Schistosoma mansoni lamin 0.0027 0.0111 0.0351
Echinococcus granulosus cyclin dependent kinase 1 0.0135 0.0779 0.2467
Trypanosoma cruzi cyclin, putative 0.0463 0.2802 1
Loa Loa (eye worm) hypothetical protein 0.0463 0.2802 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0135 0.0779 0.0779
Trichomonas vaginalis cyclin B3, putative 0.0059 0.0313 0.1068
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.001 0.0037
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0034 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0081
Schistosoma mansoni cyclin G2 0.0059 0.0313 0.0993
Echinococcus multilocularis cyclins 0.0246 0.1467 0.1467
Plasmodium vivax cyclin 4, putative 0.0059 0.0313 0.3749
Brugia malayi follicle stimulating hormone receptor 0.0229 0.1359 0.4849
Giardia lamblia Kinase, CMGC CDK 0.0135 0.0779 0.2779
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.033 0.198 0.7051
Mycobacterium ulcerans methylated-DNA--protein-cysteine methyltransferase Ogt 0.1002 0.6129 1
Echinococcus granulosus cyclin B3 1 0.0246 0.1467 0.4648
Onchocerca volvulus 0.0029 0.0128 0.0341
Onchocerca volvulus 0.0059 0.0313 0.1009
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0026 0.0081
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0061 0.0413
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0059 0.0313 0.0993
Brugia malayi Pre-SET motif family protein 0.0029 0.0128 0.0458
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0135 0.0779 0.2779
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0183 0.1075 0.3802
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1215 0.4338
Schistosoma mansoni hypothetical protein 0.052 0.3156 1
Trypanosoma cruzi cdc2-related kinase 1 0.0135 0.0779 0.2738
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0183 0.1075 0.3802
Toxoplasma gondii hypothetical protein 0.0059 0.0313 0.2848
Echinococcus granulosus cyclin dependent kinase 5 0.0135 0.0779 0.2467
Echinococcus multilocularis lamin dm0 0.0027 0.0111 0.0111
Echinococcus multilocularis cyclins 0.0246 0.1467 0.1467
Entamoeba histolytica cyclin, domain containing protein 0.0059 0.0313 0.1068
Trypanosoma cruzi cdc2-related kinase 3 0.0135 0.0779 0.2738
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0361 0.1288
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.036 0.2168 0.2168
Echinococcus multilocularis cyclins 0.0246 0.1467 0.1467
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0092
Echinococcus multilocularis musashi 0.0027 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0014 0.0034 0.0108
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0059 0.0313 0.2135
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.001 0.0037
Echinococcus multilocularis 0.0061 0.0324 0.0324
Giardia lamblia Kinase, CMGC CDK 0.0135 0.0779 0.2779
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0361 0.1143
Echinococcus granulosus cyclin 0.0059 0.0313 0.0993
Trypanosoma brucei hypothetical protein, conserved 0.0134 0.0773 0.272
Loa Loa (eye worm) cyclin domain-containing protein 0.0059 0.0313 0.1118

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = -13 % Inhibition of human Prostaglandin G/H synthase 2 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = -13 % Inhibition of human Prostaglandin G/H synthase 2 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = -11 % Inhibition of human Prostaglandin G/H synthase 2 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = -11 % Inhibition of human Prostaglandin G/H synthase 2 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = 0 % Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = 0 % Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = 14 % Inhibition of human Prostaglandin G/H synthase 1 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = 14 % Inhibition of human Prostaglandin G/H synthase 1 at 0.1 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = 25 % Inhibition of human Prostaglandin G/H synthase 1 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = 25 % Inhibition of human Prostaglandin G/H synthase 1 at 1 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = 30 % Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488
Inhibition (binding) = 30 % Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as mean percent inhibition of control PGE-2 production ChEMBL. 9083488

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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