Detailed information for compound 324477

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.816 | Formula: C15H24ClN2O2-
  • H donors: 1 H acceptors: 2 LogP: 2.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@H]2[C@@H](N1)CCCC2.[Cl-]
  • InChi: 1S/C15H24N2O2.ClH/c1-10(18)14-7-4-8-17(14)15(19)13-9-11-5-2-3-6-12(11)16-13;/h11-14,16H,2-9H2,1H3;1H/p-1/t11-,12-,13-,14-;/m0./s1
  • InChiKey: YSRZULBPZXJGNV-ZMNOQRQPSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0099 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0109 0.0556 0.0556
Schistosoma mansoni biogenic amine receptor 0.0031 0.0099 0.0157
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0031 0.0099 0.0037
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0031 0.0099 0.0157
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0099 0.0099
Echinococcus multilocularis serotonin receptor 0.0031 0.0099 0.0095
Entamoeba histolytica hypothetical protein 0.0026 0.007 0.0087
Loa Loa (eye worm) hypothetical protein 0.007 0.0326 0.0326
Echinococcus multilocularis GPCR, family 2 0.0048 0.0196 0.0192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.1011 0.1009
Echinococcus granulosus neuropeptide FF receptor 2 0.0031 0.0099 0.0095
Entamoeba histolytica hypothetical protein 0.0039 0.0145 0.0242
Loa Loa (eye worm) hypothetical protein 0.0412 0.2327 0.2327
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0099 0.0095
Echinococcus multilocularis somatostatin receptor 0.0031 0.0099 0.0095
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0029 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0346 0.1943 0.4003
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0196 0.0183
Onchocerca volvulus 0.0031 0.0099 0.0037
Brugia malayi Dopamine receptor protein 2 0.0031 0.0099 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.1011 0.1009
Brugia malayi chromobox protein homolog 3 0.0038 0.0138 0.0126
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0096 0.0083
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0136 0.0225
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0065 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Onchocerca volvulus 0.0031 0.0099 0.0037
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0052 0.0023
Loa Loa (eye worm) hypothetical protein 0.0042 0.0162 0.0162
Echinococcus multilocularis lamin dm0 0.0031 0.0096 0.0092
Echinococcus granulosus peptide allatostatin:somatostatin 0.0031 0.0099 0.0095
Brugia malayi G protein-coupled receptor 0.0031 0.0099 0.0086
Echinococcus multilocularis importin subunit beta 1 0.0031 0.01 0.0097
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.007 0.0326 0.0323
Schistosoma mansoni hypothetical protein 0.0103 0.0519 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0074 0.0094
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.003 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.041 0.2314 0.2314
Brugia malayi beta-lactamase family protein 0.0109 0.0556 0.0544
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1724 1 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0065 0.0037
Entamoeba histolytica Ran family GTPase 0.0023 0.0052 0.0048
Mycobacterium ulcerans lipase LipD 0.0109 0.0556 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0196 0.0192
Loa Loa (eye worm) hypothetical protein 0.0103 0.0519 0.0519
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0099 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.1011 0.1009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0797 0.0786
Loa Loa (eye worm) solute carrier family 6 member 4 0.0412 0.2327 0.2327
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.007 0.0326 0.0314
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Schistosoma mansoni hypothetical protein 0.0514 0.2922 0.6496
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0412 0.2327 0.2318
Onchocerca volvulus 0.0031 0.0099 0.0037
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0319 0.0528
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0319 0.4345
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.007 0.0326 0.0323
Onchocerca volvulus 0.0109 0.0556 0.2083
Toxoplasma gondii ABC1 family protein 0.0109 0.0556 0.1103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Schistosoma mansoni ran 0.0023 0.0052 0.0052
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0031 0.0099 0.0086
Echinococcus granulosus lamin 0.0031 0.0096 0.0092
Echinococcus granulosus sex peptide receptor 0.0031 0.0099 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1011 0.2206
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0029 0.0026
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Entamoeba histolytica hypothetical protein 0.0039 0.0145 0.0242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0031 0.0099 0.0157
Echinococcus multilocularis sodium and chloride dependent glycine 0.007 0.0326 0.0323
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0052 0.0048
Trichomonas vaginalis spcc417.12 protein, putative 0.0069 0.0322 0.0614
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0065 0.0037
Schistosoma mansoni lamin 0.0031 0.0096 0.015
Onchocerca volvulus 0.0069 0.0322 0.1036
Schistosoma mansoni tar DNA-binding protein 0.0196 0.1065 0.2326
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Brugia malayi Carboxylesterase family protein 0.041 0.2314 0.2305
Onchocerca volvulus Neuropeptide F receptor homolog 0.0031 0.0099 0.0037
Echinococcus granulosus g protein coupled receptor 0.0031 0.0099 0.0095
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0322 0.0659
Echinococcus granulosus hypothetical protein 0.0031 0.0099 0.0095
Giardia lamblia Macrophage migration inhibitory factor 0.0837 0.4811 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0322
Echinococcus granulosus neuropeptide receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) melatonin receptor type 1A 0.0031 0.0099 0.0099
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0029 0.0029
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0099 0.0095
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0136 0.0108
Schistosoma mansoni importin beta-1 0.0031 0.01 0.016
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.007 0.0326 0.0622
Brugia malayi RNA binding protein 0.0196 0.1065 0.1053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Brugia malayi intermediate filament protein 0.0031 0.0096 0.0083
Onchocerca volvulus 0.0109 0.0556 0.2083
Brugia malayi secreted modular calcium-binding protein 1 0.0098 0.0492 0.048
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0837 0.4811 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0162 0.0299
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0162 0.0278
Onchocerca volvulus 0.0031 0.0099 0.0037
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0098 0.0492 0.048
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0099 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0099 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0138 0.0229
Echinococcus multilocularis tar DNA binding protein 0.0196 0.1065 0.1062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.003 0.0092 0.0092
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0069 0.0322 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0837 0.4811 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0326 0.0326
Onchocerca volvulus 0.0031 0.0099 0.0037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0196 0.0192
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0519 0.0507
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0556 0.0529
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0136 0.0108
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0556 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.007 0.0326 0.0668
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0031 0.0099 0.0099
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0155 0.0264
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0099 0.0095
Echinococcus multilocularis mitogen activated protein kinase 14 0.1724 1 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0797 0.0797
Brugia malayi Heterochromatin protein 1 0.0067 0.0311 0.0299
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.1065 0.1065
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.007 0.0326 0.0326
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.007 0.0326 0.0323
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus multilocularis sodium and chloride dependent glycine 0.007 0.0326 0.0323
Loa Loa (eye worm) hypothetical protein 0.0356 0.2 0.2
Echinococcus granulosus lamin dm0 0.0031 0.0096 0.0092
Brugia malayi Dopamine receptor 0.0031 0.0099 0.0086
Brugia malayi hypothetical protein 0.0039 0.0145 0.0132
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0157
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0556 0.1139
Onchocerca volvulus 0.0055 0.0236 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.007 0.0087
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.007 0.0326 0.0668
Mycobacterium ulcerans hypothetical protein 0.0109 0.0556 1
Schistosoma mansoni lamin 0.0031 0.0096 0.015
Loa Loa (eye worm) TYRA-2 protein 0.0031 0.0099 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0098 0.0492 0.0492
Entamoeba histolytica hypothetical protein 0.0039 0.0145 0.0242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus multilocularis para nitrobenzyl esterase 0.0069 0.0322 0.0319
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0196 0.0192
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0031 0.0099 0.0157
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0162 0.0133
Schistosoma mansoni hypothetical protein 0.0048 0.0196 0.0375
Schistosoma mansoni gliotactin 0.0069 0.0322 0.0659
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0031 0.0099 0.0095
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0136 0.0225
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0556 0.0553
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0311 0.0591
Echinococcus granulosus orexin receptor type 2 0.0031 0.0099 0.0095
Echinococcus multilocularis mitogen activated protein kinase 11 0.1724 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0236 0.0224
Echinococcus multilocularis G-protein coupled receptor, putative 0.0031 0.0099 0.0095
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0099 0.0095
Echinococcus granulosus acetylcholinesterase 0.041 0.2314 0.2312
Schistosoma mansoni opsin-like receptor 0.0031 0.0099 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0556 0.1103
Schistosoma mansoni sodium/chloride dependent transporter 0.0078 0.0375 0.0776
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Onchocerca volvulus 0.0031 0.0099 0.0037
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1724 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni chromobox protein 0.0067 0.0311 0.0635
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0319 0.0651
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0052 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Echinococcus multilocularis acetylcholinesterase 0.041 0.2314 0.2312
Echinococcus granulosus g-protein coupled receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0311 0.0311
Echinococcus multilocularis carboxylesterase 5A 0.041 0.2314 0.2312
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0098 0.0492 0.048
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.283 0.2828
Brugia malayi putative neuropeptide receptor 0.0031 0.0099 0.0086
Schistosoma mansoni neuropeptide f receptor 76f 0.0031 0.0099 0.0157
Schistosoma mansoni sodium/chloride dependent transporter 0.0412 0.2327 0.5161
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.1065 0.1053
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.007 0.0326 0.0622
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0322 0.0537
Mycobacterium tuberculosis Conserved protein 0.0109 0.0556 0.1139
Onchocerca volvulus 0.0098 0.0492 0.1797
Onchocerca volvulus 0.0109 0.0556 0.2083
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0136 0.0225
Loa Loa (eye worm) hypothetical protein 0.0098 0.0492 0.0492
Brugia malayi putative neuropeptide receptor NPR1 0.0031 0.0099 0.0086
Brugia malayi follicle stimulating hormone receptor 0.0259 0.1434 0.1423
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0319 0.0316
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0412 0.2327 0.2327
Echinococcus granulosus chromobox protein 1 0.0067 0.0311 0.0308
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0099 0.0095
Echinococcus multilocularis neuropeptide FF receptor 2 0.0031 0.0099 0.0095
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.007 0.0042
Brugia malayi larval opioid receptor 0.0031 0.0099 0.0086
Plasmodium falciparum macrophage migration inhibitory factor 0.0837 0.4811 1
Onchocerca volvulus 0.0031 0.0099 0.0037
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0556 0.1139
Plasmodium falciparum transporter, putative 0.007 0.0326 0.0577
Echinococcus granulosus chromobox protein 1 0.0067 0.0311 0.0308
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0322
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0556 0.1139
Toxoplasma gondii hypothetical protein 0.007 0.0326 0.0622
Brugia malayi Melatonin receptor type 1A 0.0031 0.0099 0.0086
Schistosoma mansoni neuroligin 3 (S09 family) 0.0069 0.0322 0.0659
Loa Loa (eye worm) RNA binding protein 0.0196 0.1065 0.1065
Echinococcus granulosus tar DNA binding protein 0.0196 0.1065 0.1062
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Brugia malayi Carboxylesterase family protein 0.041 0.2314 0.2305
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0556 0.1103
Loa Loa (eye worm) hypothetical protein 0.0109 0.0556 0.0556
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.041 0.2314 0.5131
Brugia malayi G-protein coupled receptor 0.0031 0.0099 0.0086
Echinococcus granulosus g protein coupled receptor 0.0031 0.0099 0.0095
Schistosoma mansoni amine GPCR 0.0031 0.0099 0.0157
Schistosoma mansoni microtubule-associated protein tau 0.0781 0.4483 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.007 0.0042
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0031 0.0099 0.0095
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0356 0.2 0.199
Schistosoma mansoni amine GPCR 0.0031 0.0099 0.0157
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0099 0.0099
Echinococcus granulosus somatostatin receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0109 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0109 0.0556 0.0556
Brugia malayi Importin beta-1 subunit 0.0031 0.01 0.0087
Schistosoma mansoni inositol monophosphatase 0.0038 0.0136 0.0242
Loa Loa (eye worm) carboxylesterase 0.041 0.2314 0.2314
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.007 0.0326 0.0323
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0322 0.0537
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0099 0.0095
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.01 0.0071
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0334 0.1869 0.1869
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus multilocularis allatostatin A receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) carboxylesterase 0.0069 0.0322 0.0322
Echinococcus multilocularis calcium activated potassium channel 0.0018 0.0022 0.0019
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0031 0.0099 0.0095
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.007 0.0326 0.5
Mycobacterium tuberculosis Carboxylesterase LipT 0.0069 0.0322 0.0537
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0162 0.0159
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.007 0.0326 0.0323
Onchocerca volvulus 0.0069 0.0322 0.1036
Schistosoma mansoni alpha-1 adrenergic receptor 0.0031 0.0099 0.0157
Echinococcus granulosus microtubule associated protein 2 0.0781 0.4483 0.4481
Loa Loa (eye worm) hypothetical protein 0.0098 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0099 0.0157
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0556 0.1139
Mycobacterium tuberculosis Conserved protein 0.0109 0.0556 0.1139
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0099 0.0157
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0031 0.0099 0.0157
Schistosoma mansoni amine GPCR 0.0031 0.0099 0.0157
Onchocerca volvulus 0.007 0.0326 0.1054
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.007 0.0326 0.0668
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0322 0.0659
Echinococcus granulosus neuropeptide s receptor 0.0498 0.283 0.2828
Loa Loa (eye worm) hypothetical protein 0.007 0.0326 0.0326
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.283 0.2828
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.283 0.2828
Onchocerca volvulus 0.007 0.0326 0.1054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1724 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0074 0.0094
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.1482 0.1479
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0556 0.1184
Echinococcus granulosus sodium and chloride dependent glycine 0.007 0.0326 0.0323
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0031 0.0099 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1011 0.2206
Echinococcus multilocularis chromobox protein 1 0.0067 0.0311 0.0308
Schistosoma mansoni hypothetical protein 0.0334 0.1869 0.4131
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0162 0.0159
Brugia malayi Tachykinin-like peptides receptor 99D 0.0031 0.0099 0.0086
Echinococcus multilocularis microtubule associated protein 2 0.0781 0.4483 0.4481
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0029 0.0026
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0031 0.0099 0.0099
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.007 0.0326 0.0622
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0099 0.0157
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0162 0.0299
Brugia malayi Sodium:neurotransmitter symporter family protein 0.007 0.0326 0.0314
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0099 0.0095
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0162 0.0133
Leishmania major hypothetical protein, conserved 0.0109 0.0556 0.0529
Echinococcus granulosus dro:myosuppressin receptor 0.0031 0.0099 0.0095
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0136 0.0225
Entamoeba histolytica hypothetical protein 0.0039 0.0145 0.0242
Schistosoma mansoni tar DNA-binding protein 0.0196 0.1065 0.2326
Loa Loa (eye worm) hypothetical protein 0.0109 0.0556 0.0556
Brugia malayi Carboxylesterase family protein 0.0069 0.0322 0.031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0556 0.0544
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.007 0.0326 0.0326
Loa Loa (eye worm) TAR-binding protein 0.0196 0.1065 0.1065
Plasmodium falciparum importin beta, putative 0.0031 0.01 0.0101
Schistosoma mansoni opsin-like receptor 0.0031 0.0099 0.0157
Echinococcus granulosus G protein coupled receptor 139 0.0031 0.0099 0.0095
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0031 0.0099 0.0095
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0049 0.002
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0098 0.0492 0.048
Plasmodium vivax importin-beta 2, putative 0.0031 0.01 0.0101
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0319 0.0607
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0099 0.0095
Echinococcus granulosus allatostatin A receptor 0.0031 0.0099 0.0095
Schistosoma mansoni intermediate filament proteins 0.0031 0.0096 0.015
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0162 0.0149
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0031 0.0099 0.0095
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0136 0.0108
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0096 0.0096
Onchocerca volvulus 0.0031 0.0099 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.1011 0.1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0556 0.1184
Echinococcus multilocularis G protein coupled receptor 139 0.0031 0.0099 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0196 0.0192
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0048 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0055 0.0236 0.0466
Brugia malayi hypothetical protein 0.0268 0.1482 0.1471
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0099 0.0095
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0029 0.0016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0145 0.0141
Mycobacterium leprae Probable lipase LipE 0.0109 0.0556 1
Schistosoma mansoni histamine h1 receptor 0.0031 0.0099 0.0157
Schistosoma mansoni neuropeptide receptor 0.0031 0.0099 0.0157
Schistosoma mansoni BC026374 protein (S09 family) 0.0069 0.0322 0.0659
Echinococcus granulosus snurportin 1 0.0334 0.1869 0.1866
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0631 0.0631
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0311 0.0591
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0319 0.4345
Schistosoma mansoni neuropeptide receptor 0.0031 0.0099 0.0157
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0837 0.4811 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0096 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0556 0.0529
Brugia malayi hypothetical protein 0.007 0.0326 0.0314
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0698 0.4001 1
Onchocerca volvulus 0.0412 0.2327 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0797 0.0797
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0029 0.0026
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.1482 0.1479
Onchocerca volvulus 0.0098 0.0492 0.1797
Leishmania major GTP-binding protein, putative 0.0023 0.0052 0.0023
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0155 0.0289
Brugia malayi beta-lactamase family protein 0.0109 0.0556 0.0544
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0098 0.0492 0.0492
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Echinococcus granulosus neuroligin 0.0069 0.0322 0.0319
Onchocerca volvulus 0.0031 0.0099 0.0037
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0556 0.1139
Echinococcus granulosus tachykinin peptides receptor 99D 0.0031 0.0099 0.0095
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0157
Leishmania major macrophage migration inhibitory factor-like protein 0.0837 0.4811 0.4796
Brugia malayi ORL1-like opioid receptor 0.0031 0.0099 0.0086
Schistosoma mansoni biogenic amine receptor 0.0031 0.0099 0.0157
Mycobacterium tuberculosis Conserved protein 0.0109 0.0556 0.1139
Echinococcus multilocularis dro:myosuppressin receptor 0.0031 0.0099 0.0095
Onchocerca volvulus 0.0031 0.0099 0.0037
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0136 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1011 0.2206
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus multilocularis serotonin transporter 0.0412 0.2327 0.2325
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0556 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0322
Brugia malayi Serotonin receptor 0.0031 0.0099 0.0086
Brugia malayi AKH receptor 0.0031 0.0099 0.0086
Echinococcus granulosus BC026374 protein S09 family 0.0069 0.0322 0.0319
Loa Loa (eye worm) hypothetical protein 0.007 0.0326 0.0326
Loa Loa (eye worm) norepinephrine transporter 0.0412 0.2327 0.2327
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0556 0.1103
Brugia malayi neuropeptide F receptor 0.0031 0.0099 0.0086
Echinococcus granulosus uncharacterized sodium dependent transporter 0.007 0.0326 0.0323
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0069 0.0322 0.0319
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0162 0.0133
Leishmania major macrophage migration inhibitory factor-like protein 0.0837 0.4811 0.4796
Brugia malayi Inositol-1 0.0038 0.0136 0.0124
Brugia malayi MH2 domain containing protein 0.0122 0.0631 0.0619
Schistosoma mansoni tar DNA-binding protein 0.0196 0.1065 0.2326
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Onchocerca volvulus 0.0069 0.0322 0.1036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0099 0.0157
Echinococcus granulosus sodium and chloride dependent glycine 0.007 0.0326 0.0323
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0196 0.0183
Onchocerca volvulus 0.0031 0.0099 0.0037
Schistosoma mansoni hypothetical protein 0.0048 0.0196 0.0375
Loa Loa (eye worm) hypothetical protein 0.007 0.0326 0.0326
Brugia malayi TAR-binding protein 0.0196 0.1065 0.1053
Echinococcus multilocularis acetylcholinesterase 0.041 0.2314 0.2312
Schistosoma mansoni tar DNA-binding protein 0.0196 0.1065 0.2326
Echinococcus granulosus intermediate filament protein 0.0031 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Onchocerca volvulus 0.0031 0.0099 0.0037
Echinococcus granulosus mitogen activated protein kinase 11 0.1724 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Echinococcus granulosus carboxylesterase 5A 0.041 0.2314 0.2312
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0031 0.0099 0.0095
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0319 0.0316
Echinococcus multilocularis snurportin 1 0.0334 0.1869 0.1866
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0065 0.0077
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0099 0.0095
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0099 0.0095
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0162 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0556 0.1103
Loa Loa (eye worm) hypothetical protein 0.007 0.0326 0.0326
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0098 0.0492 0.0492
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0031 0.0099 0.0157
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0322
Onchocerca volvulus 0.0069 0.0322 0.1036
Echinococcus multilocularis BC026374 protein (S09 family) 0.0069 0.0322 0.0319
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0157
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0031 0.0099 0.0095
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0162 0.0278
Echinococcus multilocularis neuroligin 0.0069 0.0322 0.0319
Schistosoma mansoni neuropeptide receptor 0.0031 0.0099 0.0157
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0136 0.0225
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.1011 0.1011
Echinococcus granulosus importin subunit beta 1 0.0031 0.01 0.0097
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.1434 0.1434
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Brugia malayi beta-lactamase 0.0109 0.0556 0.0544
Loa Loa (eye worm) hypothetical protein 0.0412 0.2327 0.2327
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0031 0.0099 0.0157
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.01 0.0071
Schistosoma mansoni hypothetical protein 0.0039 0.0145 0.026
Echinococcus granulosus serotonin transporter 0.0412 0.2327 0.2325
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0029 0.0029
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0422 0.2385 0.2385
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0099 0.0157
Onchocerca volvulus 0.0069 0.0322 0.1036
Schistosoma mansoni acetylcholinesterase 0.0069 0.0322 0.0659
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.007 0.0326 0.0668
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0099 0.0095
Brugia malayi sulfakinin receptor protein 0.0031 0.0099 0.0086
Entamoeba histolytica hypothetical protein 0.0025 0.0065 0.0077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0514 0.2922 0.6496
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Brugia malayi Bm-MIF-1, identical 0.0837 0.4811 0.4805
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0099 0.0157
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Onchocerca volvulus 0.0031 0.0099 0.0037
Brugia malayi Carboxylesterase family protein 0.0069 0.0322 0.031
Echinococcus multilocularis musashi 0.0031 0.0096 0.0092
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0031 0.0099 0.0086
Onchocerca volvulus 0.0031 0.0099 0.0037
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0162 0.0278
Onchocerca volvulus 0.0031 0.0096 0.0023
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0138 0.0213
Plasmodium vivax amine transporter, putative 0.007 0.0326 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0138 0.0229
Onchocerca volvulus 0.0031 0.0099 0.0037
Brugia malayi Serotonin receptor 0.0031 0.0099 0.0086
Echinococcus multilocularis serotonin receptor 0.0031 0.0099 0.0095
Echinococcus granulosus GPCR family 2 0.0048 0.0196 0.0192
Onchocerca volvulus 0.0098 0.0492 0.1797
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1724 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0031 0.0099 0.0099
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0052 0.0048
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0162 0.0159
Echinococcus multilocularis sex peptide receptor 0.0031 0.0099 0.0095
Schistosoma mansoni growth hormone secretagogue receptor 0.0031 0.0099 0.0157
Schistosoma mansoni opsin-like receptor 0.0031 0.0099 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0145 0.0141
Plasmodium vivax hypothetical protein, conserved 0.007 0.0326 0.0577
Echinococcus granulosus uncharacterized sodium dependent transporter 0.007 0.0326 0.0323
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) carboxylesterase 0.0069 0.0322 0.0322
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0048 0.0196 0.0375
Schistosoma mansoni adenoreceptor 0.0031 0.0099 0.0157
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0099 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0031 0.0099 0.0095
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0136 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0556 0.0529
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.041 0.2314 0.2314
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0877 0.5043 0.5041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0797 0.0786
Trichomonas vaginalis ran, putative 0.0023 0.0052 0.0048
Schistosoma mansoni myosin xvIII 0.0031 0.0099 0.0157
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) beta-lactamase 0.0109 0.0556 0.0556
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0319 0.0651
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0412 0.2327 0.5161
Schistosoma mansoni neuropeptide receptor 0.0031 0.0099 0.0157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0099 0.0095
Brugia malayi hypothetical protein 0.0069 0.0322 0.031
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0099 0.0095
Echinococcus granulosus neuropeptide receptor 0.0031 0.0099 0.0095
Echinococcus multilocularis mitogen activated protein kinase 14 0.1724 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0109 0.0556 0.0556
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0145 0.026
Schistosoma mansoni amine GPCR 0.0031 0.0099 0.0157
Echinococcus multilocularis g-protein coupled receptor 0.0031 0.0099 0.0095
Echinococcus granulosus fmrfamide receptor 0.0031 0.0099 0.0095
Brugia malayi GnHR receptor homolog 0.0031 0.0099 0.0086
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.007 0.0326 0.0668
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0556 0.1139
Brugia malayi Carboxylesterase family protein 0.0069 0.0322 0.031
Echinococcus granulosus g protein coupled receptor 0.0031 0.0099 0.0095
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0162 0.0159
Toxoplasma gondii FATC domain-containing protein 0.0026 0.007 0.0087
Toxoplasma gondii hypothetical protein 0.007 0.0326 0.0622
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0031 0.0099 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0556 0.1103
Trichomonas vaginalis esterase, putative 0.0109 0.0556 0.1103
Schistosoma mansoni survival motor neuron protein 0.0055 0.0236 0.0466
Loa Loa (eye worm) acetylcholinesterase 1 0.041 0.2314 0.2314
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Echinococcus granulosus mitogen activated protein kinase 14 0.1724 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Brugia malayi Sodium:neurotransmitter symporter family protein 0.007 0.0326 0.0314
Brugia malayi Carboxylesterase family protein 0.0069 0.0322 0.031
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0556 0.0553
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0837 0.4811 1
Brugia malayi RE15519p 0.0031 0.0099 0.0086
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0099 0.0095
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0556 0.1139
Echinococcus granulosus serotonin receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Schistosoma mansoni biogenic amine receptor 0.0031 0.0099 0.0157
Onchocerca volvulus 0.0031 0.0099 0.0037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.007 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0099 0.0157
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0136 0.0133
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0319 0.0291
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0162 0.0159
Brugia malayi neuropeptide F receptor 0.0031 0.0099 0.0086
Onchocerca volvulus 0.0031 0.0099 0.0037
Onchocerca volvulus 0.007 0.0326 0.1054
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0556 0.0556
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0837 0.4811 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0326 0.0326
Schistosoma mansoni sodium-dependent amino acid transporter 0.007 0.0326 0.0668
Echinococcus multilocularis chromobox protein 1 0.0067 0.0311 0.0308
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.01 0.0149
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0031 0.0099 0.0095
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0322 0.0659
Mycobacterium ulcerans carboxylesterase, LipT 0.0069 0.0322 0.4423
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0098 0.0492 0.0492
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0052 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0099 0.0099
Brugia malayi G protein-coupled receptor F59B2.13 0.0031 0.0099 0.0086
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0837 0.4811 0.4811
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0099 0.0157
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0422 0.2385 0.2385
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0029 0.0016
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0052 0.0023
Echinococcus granulosus calcium activated potassium channel 0.0018 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0322
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0031 0.0099 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0162 0.0278
Brugia malayi Sodium:neurotransmitter symporter family protein 0.007 0.0326 0.0314
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1724 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0099 0.0095
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0052 0.0023
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0162 0.0133
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.007 0.0094
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0556 0.106
Schistosoma mansoni ran 0.0023 0.0052 0.0052
Echinococcus multilocularis mitogen activated protein kinase 11 0.1724 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0099 0.0099
Echinococcus granulosus para nitrobenzyl esterase 0.0069 0.0322 0.0319
Echinococcus granulosus serine protein kinase ATM 0.0026 0.007 0.0067
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0556 1
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0099 0.0095
Mycobacterium ulcerans beta-lactamase 0.0109 0.0556 1
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0031 0.0099 0.0157
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0136 0.0133
Schistosoma mansoni hypothetical protein 0.0048 0.0196 0.0375
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0031 0.0099 0.0086
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.007 0.0326 0.0668
Echinococcus granulosus geminin 0.0514 0.2922 0.292
Brugia malayi G-protein coupled receptor 0.0031 0.0099 0.0086
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0052 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.1011 0.1009
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0099 0.0095
Schistosoma mansoni amine GPCR 0.0031 0.0099 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0099 0.0157
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.007 0.0326 0.0668
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Brugia malayi Dopamine receptor protein 1 0.0031 0.0099 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Onchocerca volvulus 0.0031 0.0096 0.0023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0322
Loa Loa (eye worm) inositol-1 0.0038 0.0136 0.0136
Brugia malayi hypothetical protein 0.0031 0.0099 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Brugia malayi RNA, U transporter 1 0.0089 0.0437 0.0425
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0013 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Plasmodium falciparum amino acid transporter, putative 0.007 0.0326 0.0577
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0065 0.0077
Schistosoma mansoni sodium/chloride dependent transporter 0.007 0.0326 0.0668
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0162 0.0278
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.007 0.0326 0.0668
Loa Loa (eye worm) serotonin transporter b 0.0412 0.2327 0.2327
Treponema pallidum sodium- and chloride- dependent transporter 0.0412 0.2327 0.5
Schistosoma mansoni tar DNA-binding protein 0.0196 0.1065 0.2326
Echinococcus granulosus acetylcholinesterase 0.041 0.2314 0.2312
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0099 0.0095
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0155 0.0264
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus multilocularis geminin 0.0514 0.2922 0.292
Echinococcus multilocularis lamin 0.0031 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus multilocularis orexin receptor type 2 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0031 0.0099 0.0095
Schistosoma mansoni inositol monophosphatase 0.0038 0.0136 0.0242
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0322
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0031 0.0099 0.0157
Schistosoma mansoni chromobox protein 0.0067 0.0311 0.0635
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0069 0.0322 0.0319
Echinococcus granulosus alpha 1A adrenergic receptor 0.0031 0.0099 0.0095
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0099 0.0095
Schistosoma mansoni hypothetical protein 0.0031 0.0099 0.0157
Onchocerca volvulus 0.0098 0.0492 0.1797
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0268 0.1482 0.1482
Echinococcus granulosus 7tm_1 domain containing protein 0.0031 0.0099 0.0095
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0099 0.0099
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0319 0.4345

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100000 nM Inhibitory concentration against dipeptidyl peptidase IV ChEMBL. 15482928

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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