Detailed information for compound 329282

Basic information

Technical information
  • TDR Targets ID: 329282
  • Name: (Z)-3-[3-[5-(dimethylamino)-3-ethyl-2-methyl- 6-oxo-1H-pyridine-4-carbonyl]phenyl]-2-phenyl prop-2-enenitrile
  • MW: 411.496 | Formula: C26H25N3O2
  • H donors: 1 H acceptors: 4 LogP: 5.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C\c1cccc(c1)C(=O)c1c(CC)c(C)nc(c1N(C)C)O)/c1ccccc1
  • InChi: 1S/C26H25N3O2/c1-5-22-17(2)28-26(31)24(29(3)4)23(22)25(30)20-13-9-10-18(14-20)15-21(16-27)19-11-7-6-8-12-19/h6-15H,5H2,1-4H3,(H,28,31)/b21-15+
  • InChiKey: DNMOPWGIJSGICE-RCCKNPSSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-3-[3-[5-(dimethylamino)-3-ethyl-2-methyl-6-oxo-1H-pyridine-4-carbonyl]phenyl]-2-phenyl-prop-2-enenitrile
  • (Z)-3-[3-[[5-(dimethylamino)-3-ethyl-2-methyl-6-oxo-1H-pyridin-4-yl]-oxomethyl]phenyl]-2-phenyl-2-propenenitrile
  • (Z)-3-[3-[[5-(dimethylamino)-3-ethyl-2-methyl-6-oxo-1H-pyridin-4-yl]carbonyl]phenyl]-2-phenyl-prop-2-enenitrile
  • (Z)-3-[3-[3-(dimethylamino)-5-ethyl-2-keto-6-methyl-1H-pyridine-4-carbonyl]phenyl]-2-phenyl-acrylonitrile
  • (Z)-3-{3-[1-(Dimethylamino-ethyl-methyl-oxo-1,2-dihydro-pyridin-4-yl)-methanoyl]-phenyl}-2-phenyl-acrylonitrile
  • AIDS-221528
  • AIDS221528

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.1104 0.1287
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0054 0.0443 0.0443
Trypanosoma cruzi oligopeptidase b 0.0054 0.0443 0.1592
Loa Loa (eye worm) hypothetical protein 0.0045 0.0346 0.0403
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.0168 0.0168
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0308 0.2256
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0154 0.0521
Loa Loa (eye worm) hypothetical protein 0.0027 0.0154 0.0179
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0386 0.045
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.0836 1
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0308 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Onchocerca volvulus 0.0118 0.1136 0.1323
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0229 0.2343 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0084 0.0088
Plasmodium falciparum peptidase, putative 0.0054 0.0443 0.5306
Echinococcus multilocularis cpg binding protein 0.0035 0.0237 0.0237
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.0836 0.0879
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0054 0.0443 0.0443
Schistosoma mansoni hypothetical protein 0.0036 0.0252 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.0836 0.0984
Echinococcus granulosus acylamino acid releasing enzyme 0.0054 0.0443 0.0522
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0619 0.0652
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.002 0.0024
Echinococcus granulosus geminin 0.0195 0.1977 0.2329
Onchocerca volvulus 0.0054 0.0443 0.0516
Echinococcus granulosus serine protein kinase ATM 0.0029 0.0168 0.0198
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0836 0.526
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Brugia malayi basement membrane proteoglycan precursor 0.0054 0.0443 0.0516
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0154 0.0521
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0836 0.526
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0054 0.0443 0.0443
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0118 0.1136 0.1323
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0252 0.0294
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0252 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0154 0.1402
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0054 0.0443 0.0522
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Trypanosoma cruzi oligopeptidase b 0.0054 0.0443 0.1592
Echinococcus multilocularis glycoprotein Antigen 5 0.0118 0.1136 0.1136
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0203 0.2789
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0308 0.4222
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0308 0.0903
Loa Loa (eye worm) hypothetical protein 0.0331 0.3445 0.4015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0154 0.0521
Brugia malayi hypothetical protein 0.0031 0.0193 0.0225
Loa Loa (eye worm) inositol-1 0.0043 0.0319 0.0372
Brugia malayi SET domain containing protein 0.0014 0.0008 0.0009
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0054 0.0443 0.0467
Leishmania major oligopeptidase b 0.0054 0.0443 0.1592
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0173 0.0394
Toxoplasma gondii FATC domain-containing protein 0.0029 0.0168 0.0717
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0217 0.0252
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0443 0.1592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0031 0.0193 0.0225
Schistosoma mansoni hypothetical protein 0.0054 0.0443 0.0466
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0031 0.0193 0.0203
Onchocerca volvulus 0.0331 0.3445 0.4015
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0467 0.0545
Onchocerca volvulus 0.0042 0.0308 0.0359
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0118 0.1136 0.1338
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0054 0.0443 0.0516
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0319 0.4382
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0054 0.0443 0.0467
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Loa Loa (eye worm) hypothetical protein 0.0118 0.1136 0.1323
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Trichomonas vaginalis chromobox protein, putative 0.008 0.0729 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.0836 0.0836
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0173 0.2066
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0383 0.5254
Echinococcus granulosus transmembrane protease serine 3 0.0118 0.1136 0.1338
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.1089 0.1089
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0054 0.0443 0.0443
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0153 0.1517 1
Loa Loa (eye worm) trypsin family protein 0.0118 0.1136 0.1323
Mycobacterium tuberculosis Conserved protein 0.0042 0.0308 0.0903
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0499 0.1618
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0079 0.0945
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0173 0.2066
Brugia malayi Probable ClpP-like protease 0.009 0.0836 0.0974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Brugia malayi CUB domain containing protein 0.0031 0.0193 0.0225
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0054 0.0443 0.1592
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Toxoplasma gondii kringle domain-containing protein 0.0052 0.0416 0.1777
Onchocerca volvulus 0.0027 0.0154 0.0179
Onchocerca volvulus 0.0118 0.1136 0.1323
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0084 0.0761
Brugia malayi Cytochrome P450 family protein 0.0056 0.0467 0.0545
Onchocerca volvulus 0.0052 0.0416 0.0485
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0319 0.1043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0081 0.1117
Echinococcus multilocularis microtubule associated protein 2 0.0796 0.8489 0.8489
Brugia malayi beta-lactamase family protein 0.0042 0.0308 0.0359
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0031 0.0193 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Entamoeba histolytica prolyl oligopeptidase family protein 0.0054 0.0443 0.404
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0084 0.0097
Loa Loa (eye worm) hypothetical protein 0.0118 0.1136 0.1323
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Brugia malayi CUB domain containing protein 0.0031 0.0193 0.0225
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0319 0.291
Loa Loa (eye worm) prolyl oligopeptidase 0.0682 0.7251 0.8449
Schistosoma mansoni chromobox protein 0.008 0.0729 0.0767
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0168 0.0196
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0154 0.0521
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0319 0.1043
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0031 0.0193 0.0225
Schistosoma mansoni cpg binding protein 0.0033 0.0217 0.0228
Brugia malayi Calcium binding EGF domain containing protein 0.0031 0.0193 0.0225
Schistosoma mansoni hypothetical protein 0.0031 0.0193 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0308 0.0992
Schistosoma mansoni hypothetical protein 0.0031 0.0193 0.0203
Onchocerca volvulus 0.0054 0.0443 0.0516
Echinococcus granulosus glycoprotein Antigen 5 0.0118 0.1136 0.1338
Brugia malayi chromobox protein homolog 3 0.0045 0.0346 0.0403
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0308 0.3683
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0054 0.0443 0.6083
Loa Loa (eye worm) hypothetical protein 0.0118 0.1136 0.1323
Echinococcus granulosus cpg binding protein 0.0035 0.0237 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Brugia malayi Trypsin family protein 0.0118 0.1136 0.1323
Echinococcus multilocularis cubilin 0.0031 0.0193 0.0193
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0084 0.0097
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0084 0.0088
Loa Loa (eye worm) hypothetical protein 0.0027 0.0154 0.0179
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0031 0.0193 0.0225
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.0168 0.0374
Brugia malayi hypothetical protein 0.0273 0.2815 0.328
Echinococcus granulosus low density lipoprotein receptor protein 0.0054 0.0443 0.0522
Onchocerca volvulus 0.0805 0.8582 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0054 0.0443 0.0443
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0118 0.1136 0.1195
Schistosoma mansoni hypothetical protein 0.0195 0.1977 0.208
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0054 0.0443 0.0466
Echinococcus granulosus Dipeptidyl peptidase 9 0.0229 0.2343 0.276
Schistosoma mansoni hypothetical protein 0.0054 0.0443 0.0466
Echinococcus multilocularis protein patched 0.0049 0.0386 0.0386
Trypanosoma brucei prolyl oligopeptidase, putative 0.0054 0.0443 0.1592
Brugia malayi CUB domain containing protein 0.0085 0.0779 0.0907
Onchocerca volvulus 0.0031 0.0193 0.0225
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0054 0.0443 0.404
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.1104 0.1287
Mycobacterium tuberculosis Probable peptidase 0.0054 0.0443 0.1411
Loa Loa (eye worm) hypothetical protein 0.0025 0.0125 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Onchocerca volvulus 0.0014 0.0008 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0472 0.4973 0.4973
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0383 0.0446
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0081 0.1117
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0229 0.2343 1
Brugia malayi beta-lactamase 0.0042 0.0308 0.0359
Schistosoma mansoni hypothetical protein 0.0047 0.0367 0.0386
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0271 0.1717
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0054 0.0443 0.0467
Mycobacterium ulcerans hypothetical protein 0.0042 0.0308 0.159
Mycobacterium ulcerans lipoprotein LpqF 0.0073 0.0654 0.3999
Onchocerca volvulus 0.0054 0.0443 0.0516
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0154 0.0179
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0194 0.2326
Loa Loa (eye worm) hypothetical protein 0.0042 0.0308 0.0359
Trypanosoma brucei oligopeptidase b 0.0054 0.0443 0.1592
Loa Loa (eye worm) hypothetical protein 0.0049 0.0386 0.045
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0308 0.0903
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0079 0.0045
Onchocerca volvulus 0.0687 0.7304 0.8511
Loa Loa (eye worm) hypothetical protein 0.0042 0.0308 0.0359
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0308 0.0359
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0836 1
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0031 0.0193 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Loa Loa (eye worm) hypothetical protein 0.0035 0.024 0.028
Schistosoma mansoni hypothetical protein 0.0079 0.071 0.0747
Echinococcus multilocularis prolyl endopeptidase 0.0054 0.0443 0.0443
Echinococcus granulosus cubilin 0.0031 0.0193 0.0227
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0084 0.0084
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0252 0.0297
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0031 0.0193 0.0225
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0153 0.1517 0.5437
Brugia malayi prolyl oligopeptidase family protein 0.0054 0.0443 0.0517
Brugia malayi Heterochromatin protein 1 0.008 0.0729 0.0849
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0084 0.0098
Echinococcus granulosus chromobox protein 1 0.008 0.0729 0.0859
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0229 0.2343 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0194 0.0593
Schistosoma mansoni hypothetical protein 0.0047 0.0367 0.0386
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0031 0.0193 0.0484
Trichomonas vaginalis chromobox protein, putative 0.008 0.0729 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0054 0.0443 0.0522
Mycobacterium ulcerans beta-lactamase 0.0042 0.0308 0.159
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0154 0.0311
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0073 0.0654 0.2201
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Echinococcus multilocularis transmembrane protease serine 3 0.0118 0.1136 0.1136
Schistosoma mansoni hypothetical protein 0.0031 0.0193 0.0203
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0081 0.1117
Loa Loa (eye worm) hypothetical protein 0.0085 0.0779 0.0907
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Loa Loa (eye worm) hypothetical protein 0.0118 0.1136 0.1323
Loa Loa (eye worm) DOMON domain-containing protein 0.0331 0.3445 0.4015
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0054 0.0443 0.4247
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Brugia malayi Protein kinase domain containing protein 0.0052 0.0416 0.0485
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0308 0.4222
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0154 0.0521
Echinococcus granulosus CUB 0.0031 0.0193 0.0227
Schistosoma mansoni hypothetical protein 0.0036 0.0252 0.0265
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Trichomonas vaginalis esterase, putative 0.0042 0.0308 0.4222
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.002 0.0022
Brugia malayi Lectin C-type domain containing protein 0.0031 0.0193 0.0225
Toxoplasma gondii hypothetical protein 0.0054 0.0443 0.1892
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Loa Loa (eye worm) hypothetical protein 0.006 0.0505 0.0588
Brugia malayi prolyl oligopeptidase family protein 0.0054 0.0443 0.0517
Onchocerca volvulus 0.0054 0.0443 0.0516
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0319 0.1043
Brugia malayi astacin protease protein 30 0.0031 0.0193 0.0225
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0194 0.2326
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0054 0.0443 0.0443
Echinococcus granulosus low density lipoprotein receptor ldl 0.0054 0.0443 0.0522
Loa Loa (eye worm) hypothetical protein 0.0114 0.1089 0.1269
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0092
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0229 0.2343 1
Schistosoma mansoni hypothetical protein 0.0118 0.1136 0.1195
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0836 0.3566
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.2735 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.1617 0.1617
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0836 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0252 0.0294
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0054 0.0443 0.0516
Entamoeba histolytica hypothetical protein 0.0029 0.0168 0.1531
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0118 0.1136 0.1195
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.1617 0.1905
Loa Loa (eye worm) DPY-31 protein 0.0031 0.0193 0.0225
Schistosoma mansoni inositol monophosphatase 0.0043 0.0319 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0443 0.5306
Brugia malayi Kringle domain containing protein 0.0052 0.0416 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0416 0.1473
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0054 0.0443 0.2534
Brugia malayi hypothetical protein 0.0029 0.0173 0.0201
Onchocerca volvulus 0.0118 0.1136 0.1323
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0386 0.0386
Onchocerca volvulus 0.0035 0.024 0.028
Schistosoma mansoni hypothetical protein 0.0036 0.0252 0.0265
Echinococcus multilocularis enteropeptidase 0.0118 0.1136 0.1136
Brugia malayi Nematode astacin protease protein 30 0.0031 0.0193 0.0225
Loa Loa (eye worm) beta-lactamase 0.0042 0.0308 0.0359
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0252 0.0297
Schistosoma mansoni hypothetical protein 0.0036 0.0252 0.0265
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0346 0.0403
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0252 0.0294
Loa Loa (eye worm) hypothetical protein 0.0331 0.3445 0.4015
Echinococcus multilocularis tissue type plasminogen activator 0.0052 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0079 0.071 0.0827
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0084 0.0097
Schistosoma mansoni hypothetical protein 0.0031 0.0193 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0056 0.0461 0.0485
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0319 0.1671
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0031 0.0193 0.0225
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0836 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0203 0.2789
Echinococcus granulosus Mastin 0.0118 0.1136 0.1338
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0517
Brugia malayi prolyl oligopeptidase family protein 0.0054 0.0443 0.0517
Schistosoma mansoni cpg binding protein 0.0035 0.0237 0.0249
Brugia malayi HSF-type DNA-binding domain containing protein 0.0114 0.1098 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Loa Loa (eye worm) hypothetical protein 0.0042 0.0308 0.0359
Onchocerca volvulus 0.0054 0.0443 0.0516
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0044 0.0599
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0308 0.0324
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0079 0.0945
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0443 0.1592
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0499 0.0587
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0499 0.1618
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0031 0.0193 0.0203
Loa Loa (eye worm) hypothetical protein 0.0273 0.2815 0.328
Echinococcus multilocularis cubilin 0.0031 0.0193 0.0193
Schistosoma mansoni patched 1 0.0049 0.0386 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0044 0.0599
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Echinococcus granulosus prolyl endopeptidase 0.0054 0.0443 0.0522
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0031 0.0193 0.0225
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0319 0.4382
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0054 0.0443 0.1592
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0173 0.2066
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0054 0.0443 0.0516
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0054 0.0443 0.1592
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0836 1
Schistosoma mansoni hypothetical protein 0.0031 0.0193 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0154 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0346 0.4746
Onchocerca volvulus 0.0331 0.3445 0.4015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Loa Loa (eye worm) prolyl oligopeptidase 0.0054 0.0443 0.0517
Echinococcus granulosus basement membrane specific heparan sulfate 0.0054 0.0443 0.0522
Schistosoma mansoni microtubule-associated protein tau 0.0796 0.8489 0.8932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0308 0.0308
Echinococcus multilocularis geminin 0.0195 0.1977 0.1977
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0054 0.0443 0.0466
Brugia malayi CXXC zinc finger family protein 0.0033 0.0217 0.0252
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0173 0.0394
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0081 0.1117
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0889 0.9503 1
Echinococcus multilocularis GPCR, family 2 0.0036 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0047 0.0367 0.0386
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0308 0.4222
Giardia lamblia Alanyl dipeptidyl peptidase 0.0054 0.0443 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0308 0.0903
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0729 0.0849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0168 0.2306
Brugia malayi Muscle positioning protein 4 0.0331 0.3445 0.4015
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.002 0.002
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0114 0.1098 0.1279
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0461 0.0537
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0092
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0118 0.1136 0.1195
Echinococcus granulosus dnaJ subfamily B 0.0472 0.4973 0.5859
Echinococcus granulosus microtubule associated protein 2 0.0796 0.8489 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0118 0.1136 0.1195
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0193 0.2648
Brugia malayi Inositol-1 0.0043 0.0319 0.0372
Loa Loa (eye worm) hypothetical protein 0.009 0.0836 0.0974
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0308 0.0992
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.1108 0.1166
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0229 0.2343 0.2466
Plasmodium falciparum cysteine repeat modular protein 1 0.0052 0.0416 0.4985
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0054 0.0443 0.1411
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0154 0.1402
Schistosoma mansoni hypothetical protein 0.0052 0.0416 0.0438
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0229 0.2343 0.2343
Entamoeba histolytica hypothetical protein, conserved 0.0054 0.0443 0.404
Brugia malayi Calcium binding EGF domain containing protein 0.0054 0.0443 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Echinococcus multilocularis expressed conserved protein 0.0107 0.1014 0.1014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Echinococcus granulosus basement membrane specific heparan sulfate 0.0054 0.0443 0.0522
Entamoeba histolytica heat shock transcription factor, putative 0.0114 0.1098 1
Brugia malayi CUB domain containing protein 0.0031 0.0193 0.0225
Brugia malayi beta-lactamase family protein 0.0042 0.0308 0.0359
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0054 0.0443 0.404
Loa Loa (eye worm) hypothetical protein 0.0118 0.1136 0.1323
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0386 0.5294
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.071 0.0827
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Brugia malayi prolyl oligopeptidase family protein 0.0229 0.2343 0.273
Brugia malayi prolyl oligopeptidase family protein 0.0682 0.7251 0.8449
Echinococcus granulosus Tolloid protein 1 0.0031 0.0193 0.0227
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0154 0.0179
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0054 0.0443 0.0443
Schistosoma mansoni hypothetical protein 0.0195 0.1977 0.208
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.1104 0.1287
Schistosoma mansoni hypothetical protein 0.0472 0.4973 0.5233
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0173 0.0394
Entamoeba histolytica prolyl oligopeptidase family protein 0.0054 0.0443 0.404
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0319 0.0376
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0052 0.0416 0.4985
Leishmania major hypothetical protein, conserved 0.0042 0.0308 0.0992
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0308 0.159
Echinococcus granulosus expressed conserved protein 0.0107 0.1014 0.1195
Echinococcus granulosus enteropeptidase 0.0118 0.1136 0.1338
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0084 0.0097
Echinococcus granulosus cubilin 0.0031 0.0193 0.0227
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0168 0.0374
Schistosoma mansoni hypothetical protein 0.0118 0.1136 0.1195
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0805 0.8582 0.903
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0308 0.0903
Loa Loa (eye worm) hypothetical protein 0.0175 0.1757 0.2047
Toxoplasma gondii prolyl endopeptidase 0.0054 0.0443 0.1892
Echinococcus multilocularis acylamino acid releasing enzyme 0.0054 0.0443 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Leishmania major hypothetical protein, conserved 0.0052 0.0416 0.1473
Brugia malayi Kelch motif family protein 0.0031 0.0193 0.0225
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0682 0.7251 0.8541
Brugia malayi enteropeptidase precursor 0.0054 0.0443 0.0516
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0054 0.0443 0.1592
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0054 0.0443 0.6083
Loa Loa (eye worm) hypothetical protein 0.0042 0.0308 0.0359
Onchocerca volvulus 0.0031 0.0193 0.0225
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.0168 0.0177
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0054 0.0443 0.1592
Loa Loa (eye worm) hypothetical protein 0.0029 0.0173 0.0201
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0319 0.4382
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0229 0.2343 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0084 0.0357
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.2815 0.2815
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.1089 0.1269
Brugia malayi Trypsin family protein 0.0118 0.1136 0.1323
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.0836 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0081 0.1117
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0252 0.0252
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0118 0.1136 0.1136
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0271 0.0765
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0308 0.0903
Onchocerca volvulus Prolyl endopeptidase homolog 0.0054 0.0443 0.0517
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0038 0.0518
Loa Loa (eye worm) hypothetical protein 0.0052 0.0416 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Giardia lamblia Alanyl dipeptidyl peptidase 0.0054 0.0443 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0084 0.0084
Mycobacterium ulcerans hypothetical protein 0.0027 0.0154 0.0521
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0084 0.0761
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0081 0.1117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0081 0.1117
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0308 0.0362
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0308 0.0324
Onchocerca volvulus 0.0042 0.0308 0.0359
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0517
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0054 0.0443 0.0516
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0308 0.4222
Echinococcus granulosus GPCR family 2 0.0036 0.0252 0.0297
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0092
Onchocerca volvulus 0.0056 0.0461 0.0537
Brugia malayi SEA domain containing protein 0.0331 0.3445 0.4015
Brugia malayi hypothetical protein 0.0019 0.0061 0.0071
Loa Loa (eye worm) hypothetical protein 0.0114 0.1098 0.1279
Onchocerca volvulus 0.0331 0.3445 0.4015
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Brugia malayi Nematode astacin protease protein 30 0.0031 0.0193 0.0225
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Echinococcus granulosus tissue type plasminogen activator 0.0052 0.0416 0.0491
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0118 0.1136 0.1338
Toxoplasma gondii ABC1 family protein 0.0042 0.0308 0.1313
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0154 0.0179
Brugia malayi Trypsin family protein 0.0118 0.1136 0.1323
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0308 0.0992
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0092
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0383 0.5254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Echinococcus multilocularis CUB 0.0031 0.0193 0.0193
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0308 0.159
Loa Loa (eye worm) hypothetical protein 0.0042 0.0308 0.0359
Leishmania major hypothetical protein, conserved 0.0029 0.0173 0.0394
Loa Loa (eye worm) hypothetical protein 0.0805 0.8582 1
Onchocerca volvulus Arrow homolog 0.0054 0.0443 0.0516
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0225
Loa Loa (eye worm) hypothetical protein 0.0805 0.8582 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0836 1
Loa Loa (eye worm) CUB domain-containing protein 0.0031 0.0193 0.0225
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.1089 0.1283
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0319 0.0319
Mycobacterium leprae Probable lipase LipE 0.0042 0.0308 0.2256
Brugia malayi Trypsin-like protease protein 5 0.0118 0.1136 0.1323
Echinococcus multilocularis Tolloid protein 1 0.0031 0.0193 0.0193
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0154 0.0311
Onchocerca volvulus 0.0031 0.0193 0.0225
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.2815 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0031 0.0193 0.0227
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0031 0.0193 0.0484
Onchocerca volvulus 0.0042 0.0308 0.0359
Brugia malayi hypothetical protein 0.0175 0.1757 0.2047
Onchocerca volvulus 0.0331 0.3445 0.4015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Echinococcus multilocularis low density lipoprotein receptor protein 0.0054 0.0443 0.0443
Entamoeba histolytica prolyl oligopeptidase family protein 0.0054 0.0443 0.404
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0538 0.2296
Mycobacterium tuberculosis Conserved protein 0.0042 0.0308 0.0903
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0118 0.1136 0.1136
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0031 0.0193 0.0203
Brugia malayi CUB domain containing protein 0.0031 0.0193 0.0225
Trypanosoma brucei prolyl endopeptidase 0.0054 0.0443 0.1592
Schistosoma mansoni chromobox protein 0.008 0.0729 0.0767
Trypanosoma cruzi prolyl endopeptidase 0.0054 0.0443 0.1592
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0173 0.0737
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0319 0.1363
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0682 0.7251 0.8449
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0081 0.1117
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0154 0.0311
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0154 0.1402
Echinococcus granulosus low density lipoprotein receptor ldl 0.0054 0.0443 0.0522
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0154 0.0326
Schistosoma mansoni cpg binding protein 0.0035 0.0237 0.0249
Echinococcus multilocularis chromobox protein 1 0.008 0.0729 0.0729
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0084 0.0002
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0054 0.0443 0.0466
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.0416 0.0485
Schistosoma mansoni hypothetical protein 0.0331 0.3445 0.3625
Echinococcus multilocularis Mastin 0.0118 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0517
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0386 0.0455
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0054 0.0443 0.1592
Onchocerca volvulus 0.0054 0.0443 0.0516
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0084 0.0098
Trypanosoma brucei beta lactamase 0.0073 0.0654 0.2525
Echinococcus multilocularis protein dispatched 1 0.0056 0.0461 0.0461
Brugia malayi hypothetical protein 0.0118 0.1136 0.1323
Loa Loa (eye worm) hypothetical protein 0.0115 0.1104 0.1287
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.002 0.0024
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0054 0.0443 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0836 0.3566
Schistosoma mansoni hypothetical protein 0.0047 0.0367 0.0386
Schistosoma mansoni inositol monophosphatase 0.0043 0.0319 0.0336
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.1089 0.992
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0386 0.0455
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0118 0.1136 0.1195
Onchocerca volvulus 0.0331 0.3445 0.4015
Mycobacterium ulcerans lipase LipD 0.0042 0.0308 0.159
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0682 0.7251 0.763
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0054 0.0443 0.0467
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Loa Loa (eye worm) hypothetical protein 0.0042 0.0308 0.0359
Brugia malayi CHE-14 protein 0.0049 0.0386 0.045
Entamoeba histolytica heat shock transcription factor, putative 0.0114 0.1098 1
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0054 0.0443 0.1892
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0443 0.6083
Onchocerca volvulus Putative cubilin 0.0031 0.0193 0.0225
Echinococcus granulosus chromobox protein 1 0.008 0.0729 0.0859
Schistosoma mansoni cercarial elastase (S01 family) 0.0118 0.1136 0.1195
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0229 0.2343 1
Mycobacterium ulcerans hypothetical protein 0.0118 0.1136 0.7346
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0054 0.0443 0.0516
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0308 0.4222
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0319 0.1043
Entamoeba histolytica heat shock transcription factor, putative 0.0114 0.1098 1
Onchocerca volvulus 0.0118 0.1136 0.1323
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0149 0.1471 0.1548
Echinococcus multilocularis chromobox protein 1 0.008 0.0729 0.0729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Toxoplasma gondii hypothetical protein 0.0031 0.0194 0.083
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0499 0.5056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Onchocerca volvulus 0.0033 0.0217 0.0252
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0308 0.0903
Loa Loa (eye worm) hypothetical protein 0.0027 0.0154 0.0179
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0308 0.0903
Schistosoma mansoni survival motor neuron protein 0.0056 0.0461 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0073 0.0654 0.7339
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0154 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0346 0.4746
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0054 0.0443 0.0516
Onchocerca volvulus 0.0118 0.1136 0.1323
Onchocerca volvulus 0.0031 0.0193 0.0225
Brugia malayi Trypsin family protein 0.0805 0.8582 1
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0031 0.0193 0.0193
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0125 0.0181
Loa Loa (eye worm) hypothetical protein 0.0036 0.0252 0.0294
Loa Loa (eye worm) hypothetical protein 0.0054 0.0443 0.0516
Loa Loa (eye worm) CUB domain-containing protein 0.0031 0.0193 0.0225
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0308 0.0903
Brugia malayi CHD4 protein 0.0015 0.002 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0154 0.0521
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0682 0.7251 0.7251
Loa Loa (eye worm) hypothetical protein 0.0085 0.0779 0.0907
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0084 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.1147

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 uM Inhibitory activity against HIV-1 mutant strain 103N; ND = Not determined ChEMBL. 15481987
IC50 (functional) 0 uM Inhibitory activity against HIV-1 mutant strain 181C; ND = Not determined ChEMBL. 15481987
IC50 (functional) 0 uM Inhibitory activity against HIV-1 mutant strain 188L; ND = not determined ChEMBL. 15481987
IC50 (functional) = 1 uM Inhibitory activity against wild type HIV-1 LAI cell line ChEMBL. 15481987
Selectivity index (functional) = 16 uM Selectivity index of cytotoxic activity (CC50) to inhibitory activity (IC50) relative to LAI cell line ChEMBL. 15481987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.