Detailed information for compound 334671

Basic information

Technical information
  • TDR Targets ID: 334671
  • Name: (6-hydroxy-6,6-diphosphonohexyl)azanium
  • MW: 278.157 | Formula: C6H18NO7P2+
  • H donors: 6 H acceptors: 7 LogP: -5.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: [NH3+]CCCCCC(P(=O)(O)O)(P(=O)(O)O)O
  • InChi: 1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)/p+1
  • InChiKey: PUUSSSIBPPTKTP-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • (6-hydroxy-6,6-diphosphono-hexyl)ammonium
  • (6-hydroxy-6,6-diphosphonohexyl)ammonium
  • (6-hydroxy-6,6-diphosphono-hexyl)azanium
  • AIDS231606
  • Phosphonic acid, (6-amino-1-hydroxyhexylidene)bis-, conjugate acid
  • AIDS-231606

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.2277 0.227
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0048 0.0125
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0171 0.1127 0.1118
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0127 0.0806 0.0797
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0171 0.1127 0.1118
Onchocerca volvulus 0.003 0.0104 0.013
Loa Loa (eye worm) hypothetical protein 0.0114 0.0713 0.1111
Brugia malayi Dihydrofolate reductase 0.0332 0.2297 0.3585
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0463 0.0454
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0094 0.0565 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0018 0.0011
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.2277 1
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0094 0.0565 0.1792
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0097 0.0148
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.1392 1 1
Brugia malayi jmjC domain containing protein 0.0018 0.0012 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0168 0.0159
Schistosoma mansoni jun-related protein 0.0074 0.0422 0.0413
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0463 0.0454
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.026
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0017 0.0009 0.0026
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0094 0.0565 0.1792
Loa Loa (eye worm) DR-78 0.0019 0.0018 0.0025
Echinococcus multilocularis lamin 0.003 0.0104 0.0095
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0012 0.0002
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0034 0.0024
Chlamydia trachomatis endonuclease IV 0.0086 0.0511 0.2193
Loa Loa (eye worm) intermediate filament protein 0.003 0.0104 0.016
Plasmodium vivax multidomain scavenger receptor, putative 0.0088 0.0523 0.1681
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.026
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0017 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0016
Brugia malayi hypothetical protein 0.0088 0.0523 0.0815
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0168 0.026
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0171 0.1127 0.1118
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0236 0.0366
Echinococcus multilocularis RUN 0.0088 0.0523 0.0514
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0615 0.435 0.6792
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0094 0.0565 0.1792
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0168 0.0159
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0124 0.0114
Brugia malayi hypothetical protein 0.0088 0.0523 0.0815
Giardia lamblia hypothetical protein 0.0171 0.1127 0.4341
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0168 0.0159
Echinococcus multilocularis jun protein 0.0091 0.0547 0.0538
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0171 0.1127 0.1118
Brugia malayi nuclear receptor NHR-88 0.0039 0.0168 0.026
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0386 0.2685 0.2678
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0171 0.1127 0.1118
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0372 0.2583 0.2576
Echinococcus multilocularis Protein lozenge 0.0063 0.0338 0.0329
Schistosoma mansoni loxhd1 0.0088 0.0523 0.0514
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.3625
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0168 0.0159
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0949 0.6777 0.6774
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.2277 0.227
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0094 0.0565 0.2448
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0236 0.0366
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0012
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0124 0.05
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0372 0.2583 0.2576
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1392 1 1
Schistosoma mansoni nuclear receptor 0.0019 0.0018 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0068 0.0105
Schistosoma mansoni hypothetical protein 0.0054 0.0278 0.0269
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0171 0.1127 0.1118
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0016
Schistosoma mansoni lamin 0.003 0.0104 0.0095
Schistosoma mansoni rab6-interacting 0.0088 0.0523 0.0514
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0171 0.1127 0.3608
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0168 0.0159
Brugia malayi 6-phosphofructokinase 0.0123 0.0774 0.1206
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0168 0.0159
Brugia malayi Flap endonuclease-1 0.0029 0.0097 0.0148
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.0881 0.0873
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0018 0.0025
Echinococcus granulosus lamin 0.003 0.0104 0.0095
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0058 0.0049
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0168 0.0159
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0012 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0124 0.0114
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0372 0.2583 0.2576
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0101 0.0619 0.061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.026
Loa Loa (eye worm) runx1 0.0063 0.0338 0.0526
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0017 0.0009 0.0012
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0171 0.1127 0.1118
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0048 0.0125
Brugia malayi Pre-SET motif family protein 0.0897 0.6404 1
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0094 0.0565 0.1814
Schistosoma mansoni lamin 0.003 0.0104 0.0095
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.0774 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.1221 0.8756 0.8755
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0018 0.0008
Entamoeba histolytica hypothetical protein 0.008 0.0463 0.2
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.1127 0.1118
Schistosoma mansoni coup transcription factor 0.0039 0.0168 0.0159
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0146 0.0945 0.0937
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.0774 0.3369
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0168 0.026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0171 0.1127 0.1118
Brugia malayi jmjC domain containing protein 0.0066 0.0365 0.0568
Plasmodium vivax hypothetical protein, conserved 0.0443 0.3106 1
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0168 0.0159
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0443 0.3106 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0168 0.0159
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.0818 0.081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0168 0.026
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0034 0.005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0463 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0168 0.026
Mycobacterium ulcerans putative regulatory protein 0.0443 0.3106 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0124 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0168 0.026
Plasmodium vivax SET domain protein, putative 0.0129 0.0818 0.2632
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0168 0.026
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0018 0.0025
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0097 0.0306
Brugia malayi Doublecortin family protein 0.0088 0.0523 0.0815
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.0774 0.2467
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0171 0.1127 0.1118
Leishmania major hypothetical protein, conserved 0.0171 0.1127 0.1118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.2277 0.227
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1053 0.3369
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0094 0.0565 0.0556
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0101 0.0619 0.061
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0048 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.2277 0.227
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Schistosoma mansoni nuclear receptor 0.0019 0.0018 0.0008
Brugia malayi hypothetical protein 0.0021 0.0034 0.005
Echinococcus multilocularis lamin dm0 0.003 0.0104 0.0095
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.182 0.1812
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.005
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0168 0.0159
Entamoeba histolytica hypothetical protein 0.008 0.0463 0.2
Brugia malayi conserved hypotetical protein 0.0019 0.0018 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.1127 0.1118
Brugia malayi hypothetical protein 0.0267 0.182 0.2841
Trichomonas vaginalis conserved hypothetical protein 0.1221 0.8756 0.8755
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0086 0.0511 0.162
Toxoplasma gondii hypothetical protein 0.0443 0.3106 0.3547
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0034 0.0024
Loa Loa (eye worm) hypothetical protein 0.0171 0.1127 0.1758
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0124 0.0114
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.0547 0.0538
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0124 0.0114
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0171 0.1127 0.1118
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0171 0.1127 0.1118
Brugia malayi Pre-SET motif family protein 0.0129 0.0818 0.1276
Onchocerca volvulus 0.0054 0.0278 0.0368
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0171 0.1127 0.1118
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0774 0.0765
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0018 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.0774 0.1206
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.005
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0171 0.1127 0.1118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0372 0.2583 0.2576
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0168 0.0159
Echinococcus granulosus geminin 0.0336 0.2322 0.2315
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0094 0.0565 0.1792
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0097 0.0087
Giardia lamblia Hypothetical protein 0.0171 0.1127 0.4341
Brugia malayi intermediate filament protein 0.003 0.0104 0.016
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0372 0.2583 0.8312
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1392 1 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0332 0.2297 0.7387
Onchocerca volvulus 0.0072 0.0404 0.0541
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0168 0.026
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.0009 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0066 0.0365 0.0356
Loa Loa (eye worm) hypothetical protein 0.0086 0.0511 0.0796
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0278 0.0432
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.2277 0.227
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0365 0.0356
Echinococcus granulosus phd:f box containing protein 0.0018 0.0012 0.0002
Loa Loa (eye worm) dihydrofolate reductase 0.0332 0.2297 0.3585
Loa Loa (eye worm) hypothetical protein 0.0615 0.435 0.6792
Echinococcus granulosus RUN 0.0088 0.0523 0.0514
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.1127 0.1118
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0372 0.2583 0.8316
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0094 0.0565 0.0556
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0168 0.0159
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1053 0.3369
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0171 0.1127 0.1118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0073
Giardia lamblia Farnesyl diphosphate synthase 0.0372 0.2583 1
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0372 0.2583 0.2576
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0094 0.0565 0.0556
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.026
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0127 0.0806 0.0797
Schistosoma mansoni lipoxygenase 0.0386 0.2685 0.2678
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0058 0.0088
Brugia malayi steroid hormone receptor 0.0039 0.0168 0.026
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.2277 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0018 0.0008
Echinococcus granulosus Polycystic kidney disease protein 0.0088 0.0523 0.0514
Toxoplasma gondii GAF domain-containing protein 0.0443 0.3106 0.3547
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.0547 0.0538
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0048 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0034 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0012
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0511 0.1642
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.3625
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0018 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0168 0.0159
Leishmania major polyprenyl synthase, putative 0.0094 0.0565 0.0556
Giardia lamblia Fructose-bisphosphate aldolase 0.0329 0.2277 0.8811
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0171 0.1127 0.1118
Loa Loa (eye worm) hypothetical protein 0.003 0.0104 0.016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0365 0.0356
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0097 0.0087
Plasmodium falciparum LCCL domain-containing protein 0.0088 0.0523 0.166
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0058 0.0049
Mycobacterium ulcerans endonuclease IV 0.0086 0.0511 0.162
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.1118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0097 0.0087
Schistosoma mansoni hypothetical protein 0.008 0.0463 0.0454
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0018 0.0008
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0124 0.0141
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0168 0.0159
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Loa Loa (eye worm) polyprenyl synthetase 0.0372 0.2583 0.4033
Brugia malayi Polyprenyl synthetase family protein 0.0372 0.2583 0.4033
Schistosoma mansoni rab6-interacting 0.0088 0.0523 0.0514
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0086 0.0511 0.0796
Echinococcus granulosus lipoxygenase domain containing protein 0.0088 0.0523 0.0514
Brugia malayi hypothetical protein 0.0017 0.0009 0.0012
Brugia malayi hypothetical protein 0.008 0.0463 0.0721
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0012 0.0002
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Leishmania major hypothetical protein, conserved 0.0171 0.1127 0.1118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.178 0.2778
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0372 0.2583 0.8312
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.0774 0.0765
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0012 0.0016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0168 0.0159
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0168 0.026
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0094 0.0565 0.1792
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0171 0.1127 0.1118
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0168 0.0159
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0168 0.026
Brugia malayi jmjC domain containing protein 0.0018 0.0012 0.0016
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0171 0.1127 0.1118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0818 0.081
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0615 0.435 0.4344
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0097 0.0087
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0146 0.0945 0.0937
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0094 0.0565 0.0556
Toxoplasma gondii hypothetical protein 0.1221 0.8756 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0146 0.0945 0.1474
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0017 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0154
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0897 0.6404 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0012 0.0013
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0171 0.1127 0.1118
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0018 0.0025
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0017 0.0009 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.1127 0.1118
Schistosoma mansoni dihydrofolate reductase 0.0332 0.2297 0.229
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0094 0.0565 0.1792
Treponema pallidum fructose-bisphosphate aldolase 0.0329 0.2277 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0168 0.026
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0012 0.0002
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0146 0.0945 0.0937
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0146 0.0945 0.1474
Loa Loa (eye worm) hypothetical protein 0.0443 0.3106 0.4849
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.0774 0.1206
Schistosoma mansoni hypothetical protein 0.0336 0.2322 0.2315
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0615 0.435 0.4344
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0097 0.0338
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0774 0.3369
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0168 0.0218
Brugia malayi follicle stimulating hormone receptor 0.0261 0.178 0.2778
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0511 0.162
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.1127 0.1118
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.0774 0.0765
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0018 0.0008
Brugia malayi nuclear receptor NHR-88 0.0019 0.0018 0.0025
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0094 0.0565 1
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0124 0.0114
Schistosoma mansoni hypothetical protein 0.0033 0.0124 0.0115
Entamoeba histolytica hypothetical protein 0.008 0.0463 0.2
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0171 0.1127 0.3608
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0034 0.0024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0146 0.0945 0.0937
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0949 0.6777 0.6774
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0018 0.0008
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0101 0.0619 0.061
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1053 0.3369
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0171 0.1127 0.1118
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.026
Onchocerca volvulus 0.0088 0.0523 0.0705
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0097 0.011
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1392 1 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.0058 0.0049
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0012 0.0002
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0094 0.0565 0.0556
Loa Loa (eye worm) hypothetical protein 0.0039 0.0168 0.026
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0171 0.1127 0.1118
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.1118
Brugia malayi SET domain containing protein 0.0018 0.0011 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0774 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.1221 0.8756 0.8755
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0094 0.0565 0.2448
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0168 0.026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0168 0.0159
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Brugia malayi Cytochrome P450 family protein 0.0025 0.0068 0.0105
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0012 0.0002
Loa Loa (eye worm) doublecortin family protein 0.0088 0.0523 0.0815
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.1118
Onchocerca volvulus 0.1021 0.7305 1
Brugia malayi nuclear receptor NHR-67 0.0019 0.0018 0.0025
Onchocerca volvulus 0.0088 0.0523 0.0705
Chlamydia trachomatis dihydrofolate reductase 0.0332 0.2297 1
Brugia malayi hypothetical protein 0.0114 0.0713 0.1111
Leishmania major farnesyl pyrophosphate synthase 0.0372 0.2583 0.2576
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.1127 0.1118
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0171 0.1127 0.1118
Brugia malayi 6-phosphofructokinase 0.0123 0.0774 0.1206
Echinococcus granulosus intermediate filament protein 0.003 0.0104 0.0095
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0124 0.0784 0.0775
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0168 0.026
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0332 0.2297 0.7387
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0021 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Schistosoma mansoni hypothetical protein 0.0088 0.0523 0.0514
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0171 0.1127 0.4341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0818 0.081
Brugia malayi jmjC domain containing protein 0.0066 0.0365 0.0568
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0086 0.0511 0.162
Onchocerca volvulus 0.0019 0.0018 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0168 0.026
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.0881 0.0873
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0012 0.0002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Loa Loa (eye worm) hypothetical protein 0.0267 0.182 0.2841
Plasmodium falciparum phosphodiesterase gamma, putative 0.0171 0.1127 0.3608
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0818 0.0935
Leishmania major solanesyl-diphosphate synthase, putative 0.0094 0.0565 0.0556
Loa Loa (eye worm) hypothetical protein 0.0088 0.0523 0.0815
Loa Loa (eye worm) hypothetical protein 0.0171 0.1127 0.1758
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0171 0.1127 0.1118
Leishmania major hypothetical protein, conserved 0.0018 0.0012 0.0002
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0171 0.1127 0.1118
Brugia malayi ecdysteroid receptor 0.0039 0.0168 0.026
Brugia malayi bZIP transcription factor family protein 0.0091 0.0547 0.0851
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0171 0.1127 0.1118
Loa Loa (eye worm) hypothetical protein 0.0114 0.0713 0.1111
Brugia malayi tailless protein 0.0019 0.0018 0.0025
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0615 0.435 0.6792
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0018 0.0025
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0124 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.1127 0.1118
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0365 0.0356
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.3608
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0094 0.0565 0.2448
Plasmodium vivax JmjC domain containing protein 0.0018 0.0012 0.0033
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Echinococcus multilocularis musashi 0.003 0.0104 0.0095
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0171 0.1127 0.1758
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0168 0.0159
Schistosoma mansoni hypothetical protein 0.0074 0.0422 0.0413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0372 0.2583 0.8312
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.0774 0.0765
Trypanosoma brucei hypothetical protein, conserved 0.0171 0.1127 0.1118
Schistosoma mansoni thyroid hormone receptor 0.0177 0.1166 0.1158
Brugia malayi phosphofructokinase 0.0123 0.0774 0.1206
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.0009 0.0012
Trypanosoma cruzi polyprenyl synthase, putative 0.0094 0.0565 0.0556
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0124 0.0141
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0097 0.0384
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0146 0.0945 0.0937
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0094 0.0565 0.0556
Echinococcus granulosus lipoxygenase domain containing protein 0.0088 0.0523 0.0514
Onchocerca volvulus 0.0114 0.0713 0.0964
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.005
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0124 0.0369
Trypanosoma cruzi polyprenyl synthase, putative 0.0094 0.0565 0.0556
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0018 0.0008
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0094 0.0565 0.0645
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Brugia malayi jmjC domain containing protein 0.0018 0.0012 0.0016
Echinococcus granulosus jun protein 0.0091 0.0547 0.0538
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0365 0.0356
Mycobacterium leprae conserved hypothetical protein 0.0443 0.3106 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0171 0.1127 0.1118
Echinococcus granulosus transcription factor Dp 1 0.0085 0.0498 0.0489
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0171 0.1127 0.1758
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0168 0.0159
Toxoplasma gondii hypothetical protein 0.0443 0.3106 0.3547
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0171 0.1127 0.1118
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0104 0.016
Plasmodium falciparum flap endonuclease 1 0.0029 0.0097 0.0281
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0012 0.0002
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0171 0.1127 0.1118
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0372 0.2583 0.2576
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0774 0.3369
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0949 0.6777 0.6774
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0012 0.0002
Mycobacterium ulcerans putative regulatory protein 0.0443 0.3106 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1392 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.1127 0.1118
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0124 0.0141
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0124 0.0444
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0774 0.0765
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0774 0.0765
Echinococcus multilocularis transcription factor Dp 1 0.0085 0.0498 0.0489
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0372 0.2583 0.2576
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0168 0.026
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.1127 0.1118
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.1392 1 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.3608
Brugia malayi jmjC domain containing protein 0.0018 0.0012 0.0016
Echinococcus granulosus flap endonuclease 1 0.0029 0.0097 0.0087
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0104 0.016
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0171 0.1127 0.1118
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0012 0.0002
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.0774 0.2467
Onchocerca volvulus 0.0039 0.0168 0.0218
Entamoeba histolytica hypothetical protein 0.008 0.0463 0.2
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0094 0.0565 0.2427
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0146 0.0945 0.4127
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0168 0.0159
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0372 0.2583 0.295
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0171 0.1127 0.1758
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0168 0.0159
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0018 0.0025
Loa Loa (eye worm) RecQ helicase 0.0024 0.0058 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0012 0.0016
Schistosoma mansoni lipoxygenase 0.0227 0.1533 0.1525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.2277 0.227
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0168 0.0159
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.1118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0168 0.026
Loa Loa (eye worm) hypothetical protein 0.0033 0.0124 0.0192
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0171 0.1127 0.1118
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0168 0.026
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0127 0.0806 0.2572
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0017 0.0009 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0034 0.005
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0017 0.0009 0.0011
Brugia malayi M-phase phosphoprotein, mpp8 0.0114 0.0713 0.1111
Loa Loa (eye worm) polyprenyl synthetase 0.0094 0.0565 0.0879
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0127 0.0806 0.0921
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0168 0.026
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0168 0.0218
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0171 0.1127 0.1758
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0146 0.0945 0.0937
Schistosoma mansoni flap endonuclease-1 0.0027 0.0076 0.0067
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0443 0.3106 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0012 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0018 0.0008
Echinococcus multilocularis dihydrofolate reductase 0.0332 0.2297 0.229
Brugia malayi hypothetical protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0018 0.0025
Plasmodium vivax unspecified product 0.0017 0.0009 0.0026
Schistosoma mansoni glutathione synthetase 0.0094 0.0565 0.0556
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0012 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0168 0.026
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0365 0.0356
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.3625
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0033
Loa Loa (eye worm) hypothetical protein 0.0088 0.0523 0.0815
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.0774 0.2467
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Brugia malayi ecdysone receptor 0.0019 0.0018 0.0025
Schistosoma mansoni polycystin 1-related 0.0088 0.0523 0.0514
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0018 0.0025
Brugia malayi nuclear receptor RXR 0.0019 0.0018 0.0025
Schistosoma mansoni zinc finger protein 0.0019 0.0018 0.0008
Brugia malayi dihydrofolate reductase family protein 0.0332 0.2297 0.3585
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0012 0.0002
Plasmodium vivax phosphodiesterase gamma, putative 0.0171 0.1127 0.3625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0818 0.081
Brugia malayi ethe1-prov protein 0.0017 0.0009 0.0012
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0018 0.0011
Loa Loa (eye worm) PDE1B protein 0.0171 0.1127 0.1758
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0012 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1392 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0124 0.0114
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0443 0.3106 1
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0094 0.0565 0.0556
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0124 0.0114
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0171 0.1127 0.1118
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0018 0.0008
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1392 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0236 0.0366
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0018 0.0025
Echinococcus granulosus lamin dm0 0.003 0.0104 0.0095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0089 0.0528 0.0823
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0018 0.0008
Loa Loa (eye worm) phosphofructokinase 0.0123 0.0774 0.1206
Mycobacterium ulcerans hypothetical protein 0.0023 0.0048 0.0125
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0094 0.0565 0.0556
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.0774 0.0765
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0018 0.0008
Onchocerca volvulus 0.0114 0.0713 0.0964
Onchocerca volvulus 0.003 0.0104 0.013
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0168 0.0159
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0094 0.0565 0.0556
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0372 0.2583 0.2576
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0615 0.435 0.4344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0168 0.0159
Brugia malayi nuclear hormone receptor 0.0019 0.0018 0.0025
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0124 0.0394
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.1127 0.1758
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.0818 0.081
Loa Loa (eye worm) hypothetical protein 0.0049 0.0236 0.0366
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0094 0.0565 0.0879
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0615 0.435 0.4344
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0012 0.0013
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0124 0.0504
Schistosoma mansoni hypothetical protein 0.0137 0.0881 0.0873
Echinococcus multilocularis thyroid hormone receptor alpha 0.0177 0.1166 0.1158
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0818 0.081
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0037 0.0088
Onchocerca volvulus 0.0019 0.0018 0.0011
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0018 0.0008
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.1127 0.1118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Brugia malayi hypothetical protein 0.0021 0.0034 0.005
Schistosoma mansoni trans-prenyltransferase 0.0094 0.0565 0.0556
Onchocerca volvulus 0.0142 0.0912 0.1237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0168 0.026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0358 0.2482 0.3874
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0386 0.2685 0.2678
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0018 0.0008
Loa Loa (eye worm) hypothetical protein 0.0129 0.0818 0.1276
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0018 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Schistosoma mansoni hypothetical protein 0.0336 0.2322 0.2315
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0124 0.0369
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0127 0.0806 0.2592
Echinococcus multilocularis lysine specific demethylase 5A 0.0066 0.0365 0.0356
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0012 0.0002
Echinococcus multilocularis geminin 0.0336 0.2322 0.2315
Trichomonas vaginalis set domain proteins, putative 0.1021 0.7305 0.7302
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.182 0.1812
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0615 0.435 0.4344
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0168 0.026
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0101 0.0619 0.061
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0168 0.0159
Brugia malayi hypothetical protein 0.0137 0.088 0.1373
Brugia malayi Polyprenyl synthetase family protein 0.0094 0.0565 0.0879
Toxoplasma gondii endonuclease IV APN 0.0086 0.0511 0.0584
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0372 0.2583 0.8312
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0171 0.1127 0.1118
Schistosoma mansoni survival motor neuron protein 0.0054 0.0278 0.0269
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0094 0.0565 0.1792
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0365 0.0568
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1392 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0774 0.3369
Schistosoma mansoni intermediate filament proteins 0.003 0.0104 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0168 0.026
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.1118
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1
Treponema pallidum octaprenyl-diphosphate synthase 0.0094 0.0565 0.2448
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0168 0.0218
Brugia malayi hypothetical protein 0.0072 0.0404 0.0629
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0332 0.2297 0.7387
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0012 0.0007
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0018 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0177 0.1166 0.1158
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0034 0.0024
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0171 0.1127 0.1118
Brugia malayi nuclear hormone receptor 0.0039 0.0168 0.026
Plasmodium falciparum GAF domain-related protein, putative 0.0443 0.3106 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0615 0.435 0.4344
Brugia malayi nuclear receptor RXR 0.0021 0.0034 0.005
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0094 0.0565 0.0556
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0094 0.0565 0.0556
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0124 0.0394
Schistosoma mansoni lozenge 0.0063 0.0338 0.0329
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1392 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.0774 0.0765
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0171 0.1127 0.1758
Brugia malayi hypothetical protein 0.0019 0.0018 0.0025
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0058 0.0049
Plasmodium falciparum phosphodiesterase delta, putative 0.0171 0.1127 0.3608
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.0774 0.0765
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0168 0.026
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0097 0.0087
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0171 0.1127 0.1287
Mycobacterium ulcerans epimerase 0.0023 0.0048 0.0125
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0168 0.0159
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0171 0.1127 0.1118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0168 0.026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0012 0.0002
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1392 1 1
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0372 0.2583 0.2576
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0018 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0443 0.3106 0.31
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0012 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.2277 0.227
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0094 0.0565 0.0879
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0146 0.0945 0.0937
Echinococcus multilocularis Polycystic kidney disease protein 0.0088 0.0523 0.0514
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0142 0.0912 0.0903
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0168 0.0159
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0124 0.0192
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0127 0.0806 0.0797
Echinococcus multilocularis lipoxygenase domain containing protein 0.0088 0.0523 0.0514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.2277 0.227
Echinococcus granulosus dihydrofolate reductase 0.0332 0.2297 0.229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0168 0.026
Echinococcus multilocularis lipoxygenase domain containing protein 0.0088 0.0523 0.0514
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0025
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0171 0.1127 0.1118
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1392 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 59.7 uM In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) ChEMBL. 15857119
LD50 (functional) = 680 uM Lethal dose required to inhibit the growth of human KB (nasopharyngeal carcinoma) cell line ChEMBL. 15857119
TI (functional) = 11.39 Therapeutic index (TI) value as ratio of lethal dose (LD50) to the inhibitory concentration (IC50) ChEMBL. 15857119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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