Detailed information for compound 335554

Basic information

Technical information
  • TDR Targets ID: 335554
  • Name: 2-hydroxy-6-(4-hydroxyphenyl)naphthalene-1-ca rbonitrile
  • MW: 261.275 | Formula: C17H11NO2
  • H donors: 2 H acceptors: 3 LogP: 4.36 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(O)ccc2c1ccc(c2)c1ccc(cc1)O
  • InChi: 1S/C17H11NO2/c18-10-16-15-7-3-12(9-13(15)4-8-17(16)20)11-1-5-14(19)6-2-11/h1-9,19-20H
  • InChiKey: QZUOTBJDFQFRGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydroxy-6-(4-hydroxyphenyl)-1-naphthalenecarbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0124 0.1834 0.2393
Loa Loa (eye worm) hypothetical protein 0.0242 0.3844 0.3844
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0363
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0365 0.095
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0242 0.3844 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0363 0.4425
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0363 0.0363
Schistosoma mansoni alpha-glucosidase 0.0146 0.2203 0.2874
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.006 0.0751 0.0751
Leishmania major geranylgeranyltransferase, putative 0.006 0.0751 0.2145
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0007 0.0007
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0124 0.1834 0.4771
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0363 0.0937
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0376 0.0978
Loa Loa (eye worm) hypothetical protein 0.0248 0.3943 0.3943
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.006 0.0751 0.0751
Schistosoma mansoni DNA helicase recq1 0.0019 0.0052 0.0068
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0126 0.1866 0.1866
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0076 0.0195
Plasmodium falciparum thioredoxin reductase 0.0047 0.0533 0.1386
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0365 0.095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0363
Schistosoma mansoni inositol monophosphatase 0.0038 0.0376 0.049
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0363
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.006 0.0751 0.098
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0007 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0007 0.0009
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.006 0.0751 0.0869
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.1834 0.4739
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0694 0.1981
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0006 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0365 0.095
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0037 0.0363 0.1977
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0222 0.3503 0.9113
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0116 0.0134
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0242 0.3844 1
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.006 0.0751 0.098
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0222 0.3503 0.9113
Brugia malayi beta-lactamase 0.0037 0.0363 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0751 0.1941
Leishmania major lanosterol synthase, putative 0.0183 0.2846 0.8123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0007 0.0007
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0076
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0006 0.0016
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0006 0.0018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0007 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.3788 0.9788
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0006 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0179 0.2775 0.3621
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0052 0.0136
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0076 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1295 0.1499
Plasmodium falciparum glutathione reductase 0.0016 0.0006 0.0016
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.006 0.0751 0.0869
Onchocerca volvulus 0.0037 0.0363 0.1977
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0006 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0819 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0007 0.0008
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0052 0.0061
Schistosoma mansoni DNA helicase recq5 0.0019 0.0052 0.0068
Loa Loa (eye worm) hypothetical protein 0.006 0.0751 0.0751
Schistosoma mansoni hypothetical protein 0.0297 0.4783 0.624
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0052 0.0136
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0365 0.095
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0467 0.7665 1
Echinococcus granulosus importin subunit beta 1 0.0028 0.0201 0.0232
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0006 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0007 0.0008
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0467 0.7665 0.8869
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0376 0.0435
Leishmania major hypothetical protein, conserved 0.0051 0.0593 0.1694
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.006 0.0751 0.0869
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0052 0.0052
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0052 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0363 0.0937
Leishmania major importin beta-1 subunit, putative 0.0023 0.0111 0.0317
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0006 0.0018
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0052 0.0052
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0007 0.0008
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0222 0.3503 0.9113
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0052
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0111 0.0289
Plasmodium falciparum importin beta, putative 0.0028 0.0201 0.0522
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0006 0.0076
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0363 0.0937
Echinococcus granulosus geminin 0.0179 0.2775 0.3211
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0052 0.0061
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0308 0.1739
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0244 0.387 1
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1771 0.4575
Schistosoma mansoni alpha-glucosidase 0.0146 0.2203 0.2874
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Brugia malayi POT family protein 0.0042 0.0444 0.0444
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0242 0.3844 1
Mycobacterium tuberculosis Probable reductase 0.0108 0.1566 0.4045
Onchocerca volvulus 0.0098 0.1391 0.7582
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0363 0.0937
Loa Loa (eye worm) POT family protein 0.0042 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0242 0.3844 0.5015
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0694 0.0694
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.006 0.0751 0.1954
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0076 0.0196
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0007 0.0007
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0365 0.1042
Schistosoma mansoni inositol monophosphatase 0.0038 0.0376 0.049
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.006 0.0751 0.2145
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0248 0.3943 0.3943
Schistosoma mansoni importin beta-1 0.0028 0.0201 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0007 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0007 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0007 0.0008
Giardia lamblia Rab geranylgeranyltransferase 0.0242 0.3844 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0376 0.0978
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0007 0.0007
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0006 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0694 0.1793
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0694 0.0694
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0533 0.0617
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0467 0.7665 0.7665
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0052 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0007 0.0008
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0124 0.1834 0.2122
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0694 0.1805
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0052 0.015
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0363 0.2047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1295 0.1499
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0016
Mycobacterium ulcerans beta-lactamase 0.0037 0.0363 0.4425
Leishmania major trypanothione reductase 0.0047 0.0533 0.1521
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1771 0.4575
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0111 0.0289
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0007 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0819 0.0948
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0006 0.0016
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.006 0.0751 0.1941
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0074 0.0193
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0694 0.1805
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0694 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0363 0.0943
Plasmodium falciparum geranylgeranyltransferase, putative 0.006 0.0751 0.1954
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0006 0.0076
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0242 0.3844 0.3844
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0007 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0694 0.1805
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0007 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0007 0.0008
Entamoeba histolytica hypothetical protein 0.0023 0.0111 0.0289
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0007 0.0008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0052 0.0061
Schistosoma mansoni coup transcription factor 0.0016 0.0007 0.0009
Echinococcus multilocularis geminin 0.0179 0.2775 0.3211
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.006 0.0751 0.0751
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1771 0.4575
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.2603 0.3012
Brugia malayi RNA, U transporter 1 0.0079 0.1074 0.1074
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0006 0.0018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0006 0.0016
Entamoeba histolytica Ran family GTPase 0.0021 0.0076 0.0196
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0007 0.0039
Plasmodium falciparum glutathione reductase 0.0047 0.0533 0.1386
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0222 0.3503 1
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0124 0.1834 0.4739
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0201 0.0518
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0124 0.1834 0.2122
Mycobacterium ulcerans lipase LipD 0.0037 0.0363 0.4425
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0363 0.0943
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0365 0.0423
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0124 0.1834 0.4739
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.006 0.0751 0.1954
Mycobacterium leprae Probable lipase LipE 0.0037 0.0363 0.2047
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0694 0.1805
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0007 0.0008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0076 0.0195
Brugia malayi beta-lactamase family protein 0.0037 0.0363 0.0363
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1295 0.1499
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0222 0.3503 0.9052
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0201 0.0232
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0124 0.1834 0.4771
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0052 0.0136
Toxoplasma gondii hypothetical protein 0.0124 0.1834 0.5235
Trichomonas vaginalis esterase, putative 0.0037 0.0363 0.0943
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0819 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0363 0.0937
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0006 0.0016
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0222 0.3503 0.9113
Trypanosoma cruzi protein farnesyltransferase, putative 0.0222 0.3503 0.9052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0052 0.0052
Echinococcus granulosus snurportin 1 0.0297 0.4783 0.5534
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0819 0.2339
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0242 0.3844 0.4448
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0124 0.1834 0.4739
Toxoplasma gondii hypothetical protein 0.0118 0.1737 0.4959
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.1834 0.4739
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0222 0.3503 0.4053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1295 0.169
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0365 0.095
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0201 0.0518
Mycobacterium tuberculosis Conserved protein 0.0037 0.0363 0.0937
Schistosoma mansoni ran 0.0021 0.0076 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1295 0.1499
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0007 0.0009
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0111 0.0287
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0819 0.1069
Toxoplasma gondii exonuclease III APE 0.0057 0.0694 0.1981
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0076 0.0076
Loa Loa (eye worm) beta-lactamase 0.0037 0.0363 0.0363
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0376 0.1073
Brugia malayi Thioredoxin reductase 0.0047 0.0533 0.0533
Treponema pallidum NADH oxidase 0.0016 0.0006 0.009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1566 0.4045
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0007 0.0007
Brugia malayi hypothetical protein 0.0051 0.0593 0.0593
Schistosoma mansoni ap endonuclease 0.0057 0.0694 0.0905
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0124 0.1834 0.1834
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0006 0.0016
Mycobacterium tuberculosis Conserved protein 0.0037 0.0363 0.0937
Loa Loa (eye worm) RecQ helicase 0.0019 0.0052 0.0052
Brugia malayi steroid hormone receptor 0.0016 0.0007 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0006 0.0016
Brugia malayi nuclear hormone receptor 0.0016 0.0007 0.0007
Giardia lamblia Rab geranylgeranyltransferase 0.006 0.0751 0.1954
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0593 0.1543
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0593 0.1543
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0201 0.0573
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0365 0.0944
Onchocerca volvulus 0.0016 0.0007 0.0039
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0376 0.4588
Brugia malayi hypothetical protein 0.0033 0.0286 0.0286
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.006 0.0751 0.1954
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0124 0.1834 0.4739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0007 0.0007
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0222 0.3503 0.9113
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.1834 0.4739
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0365 0.0944
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0365 0.095
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0376 0.0435
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0365 0.1042
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.0074 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0751 0.1941
Brugia malayi Importin beta-1 subunit 0.0028 0.0201 0.0201
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1825 0.1825
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0007 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0694 0.0803
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.2603 0.2603
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0242 0.3844 1
Brugia malayi ecdysteroid receptor 0.0016 0.0007 0.0007
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0376 0.1073
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0593 0.1533
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0007 0.0008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0363 0.0363
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0694 0.1793
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0376 0.0971
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0052 0.0136
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0694 0.8469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0007 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1295 0.1295
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0694 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0007 0.0009
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0006 0.0018
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0376 0.5417
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0819 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0593 0.1543
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0593 0.1533
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0363 0.0473
Schistosoma mansoni alpha glucosidase 0.0038 0.0365 0.0476
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0222 0.3503 0.9113
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0365 0.095
Leishmania major GTP-binding protein, putative 0.0021 0.0076 0.0216
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0363 0.0943
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0593 0.1694
Leishmania major farnesyltransferase beta subunit 0.0222 0.3503 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1566 0.4045
Trypanosoma cruzi lanosterol synthase, putative 0.0244 0.387 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0006 0.009
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.006 0.0751 0.0751
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0076 0.0196
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1771 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Plasmodium vivax glutathione reductase, putative 0.0047 0.0533 0.1386
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1825 0.1825
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0124 0.1834 0.2122
Echinococcus multilocularis snurportin 1 0.0297 0.4783 0.5534
Trypanosoma brucei lanosterol synthase 0.0244 0.387 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0016
Onchocerca volvulus 0.0124 0.1834 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0007 0.0008
Schistosoma mansoni ap endonuclease 0.0057 0.0694 0.0905
Onchocerca volvulus 0.0037 0.0363 0.1977
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0363 0.4425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1295 0.169
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1566 0.8841
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0242 0.3844 0.4448
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.006 0.0751 0.1954
Mycobacterium tuberculosis Conserved protein 0.0037 0.0363 0.0937
Plasmodium vivax geranylgeranyltransferase, putative 0.006 0.0751 0.1954
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0365 0.095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0016
Loa Loa (eye worm) inositol-1 0.0038 0.0376 0.0376
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0363 0.0937
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0018
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.006 0.0751 0.098
Schistosoma mansoni hypothetical protein 0.0023 0.0116 0.0151
Loa Loa (eye worm) glutathione reductase 0.0047 0.0533 0.0533
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0007 0.0008
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0222 0.3503 0.9113
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0604 1 1
Brugia malayi Inositol-1 0.0038 0.0376 0.0376
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0694 0.0803
Giardia lamblia Rab geranylgeranyltransferase 0.0124 0.1834 0.4771
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.006 0.0751 0.1954
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0007 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0006 0.0016
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0819 0.0948
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0593 0.1533
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0533 0.0617
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0052 0.0136
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0222 0.3503 0.457
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0016
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0365 0.0423
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0467 0.7665 0.8869
Giardia lamblia Prenyltransferase 0.0222 0.3503 0.9113
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0124 0.1834 0.4739
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0376 0.0971
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0052 0.0061
Toxoplasma gondii ABC1 family protein 0.0037 0.0363 0.1035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.0037 0.0363 0.4425
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0242 0.3844 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0201 0.0201
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.006 0.0751 0.1954
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0116 0.0134
Brugia malayi nuclear receptor NHR-88 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0819 0.2117
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0052 0.0136
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0365 0.095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0363
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0076 0.0216
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0376 0.0971
Trypanosoma brucei trypanothione reductase 0.0047 0.0533 0.1377
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0363 0.0937
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1566 0.4045
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0533 0.1377
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0365 0.095
Plasmodium vivax importin-beta 2, putative 0.0028 0.0201 0.0522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0363 0.0473
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0363 0.0419
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0222 0.3503 0.4053
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0007 0.0039
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0222 0.3503 0.9113
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.2603 0.3012
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0363 0.0937
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0363 0.0943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0007 0.0007
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0052 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0363 0.0943
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0524 0.8643 1
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0533 0.1386
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0052 0.015
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0242 0.3844 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0006 0.0016
Plasmodium falciparum thioredoxin reductase 0.0016 0.0006 0.0016
Brugia malayi MH2 domain containing protein 0.0123 0.1825 0.1825
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0376 0.0978
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0007 0.0008
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0124 0.1834 0.5235
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0363 0.0943
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0376 0.0978
Echinococcus granulosus bloom syndrome protein 0.0019 0.0052 0.0061
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0076 0.0195
Brugia malayi glutathione reductase 0.0047 0.0533 0.0533
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0122 0.1804 0.1804
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0007 0.0039
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0533 0.0533
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0007 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0007 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0007 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0007 0.0007
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.2603 0.2603
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0007 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0007 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0006 0.0016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0018
Trichomonas vaginalis ran, putative 0.0021 0.0076 0.0196
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0819 0.2339
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.006 0.0751 0.1941
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0124 0.1834 0.4739
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1295 0.1295
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0124 0.1834 0.2122
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.4783 0.4783
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0007 0.0009
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0242 0.3844 0.3844
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0007 0.0008
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0222 0.3503 0.9113
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0076 0.0087
Schistosoma mansoni ran 0.0021 0.0076 0.0099
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0162 0.2479 0.6448
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0365 0.0365
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0365 0.095
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0124 0.1834 0.4771
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0007 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0007 0.0009
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0467 0.7665 0.7665
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0052 0.015
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0076 0.0087
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0694 0.1793
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0052 0.0136
Trypanosoma brucei glucosidase, putative 0.0038 0.0365 0.0944
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0363 0.0419
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0694 0.1805
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0365 0.0365
Schistosoma mansoni dopamine-beta-monooxygenase 0.0248 0.3943 0.5144
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0006 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0308 0.0796
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0363
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0124 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0363
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0363 0.0937
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0016
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0222 0.3503 0.3503
Echinococcus granulosus tm gpcr rhodopsin 0.0524 0.8643 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0124 0.1834 0.4771
Loa Loa (eye worm) hypothetical protein 0.0051 0.0593 0.0593
Toxoplasma gondii thioredoxin reductase 0.0047 0.0533 0.1521
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1566 0.4045
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.006 0.0751 0.2145
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0819 0.1069
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0052 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0006 0.0016
Leishmania major hypothetical protein, conserved 0.0037 0.0363 0.1035
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0076 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0694 0.1805
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.2603 0.3012
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0006 0.0016
Brugia malayi beta-lactamase family protein 0.0037 0.0363 0.0363
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0222 0.3503 0.3503
Schistosoma mansoni hypothetical protein 0.0179 0.2775 0.3621
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0533 0.1377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1295 0.169
Trypanosoma cruzi lanosterol synthase, putative 0.0244 0.387 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1566 0.4045
Trypanosoma cruzi protein farnesyltransferase, putative 0.0222 0.3503 0.9052
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0363 0.0937
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0118 0.1737 0.4519
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0111 0.0289
Schistosoma mansoni peptidylglycine monooxygenase 0.0248 0.3943 0.5144
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0007 0.0007
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.006 0.0751 0.1954

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 81 nM Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor beta expressed in Escherichia coli ChEMBL. 15943471
IC50 (binding) = 81 nM Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor beta expressed in Escherichia coli ChEMBL. 15943471
IC50 (binding) = 1402 nM Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha expressed in Escherichia coli ChEMBL. 15943471
IC50 (binding) = 1402 nM Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha expressed in Escherichia coli ChEMBL. 15943471
Ratio (binding) = 17 Relative inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha and beta expressed in Escherichia coli ChEMBL. 15943471
Ratio (binding) = 17 Relative inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha and beta expressed in Escherichia coli ChEMBL. 15943471

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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