Detailed information for compound 335833

Basic information

Technical information
  • TDR Targets ID: 335833
  • Name: (3-amino-1-hydroxy-1-phosphonopropyl)phosphon ic acid
  • MW: 235.069 | Formula: C3H11NO7P2
  • H donors: 6 H acceptors: 7 LogP: -6.9 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCC(P(=O)(O)O)(P(=O)(O)O)O
  • InChi: 1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
  • InChiKey: WRUUGTRCQOWXEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • APD
  • Acide pamidronique [INN-French]
  • Acido pamidronico [INN-Spanish]
  • Acidum pamidronicum [INN-Latin]
  • Pamidronate
  • Pamidronate Disodium
  • Pamidronic acid
  • (3-amino-1-hydroxy-1-phosphono-propyl)phosphonic acid
  • (3-azanyl-1-hydroxy-1-phosphono-propyl)phosphonic acid
  • 40391-99-9
  • STOCK1N-12562
  • C07395
  • (3-Amino-1-hydroxypropylidene)bisphosphonic acid
  • (3-Amino-1-hydroxypropylidene)diphosphonic acid
  • Amidronate
  • EINECS 254-905-2
  • Pamidronic acid [BAN:INN]
  • ChemDiv1_025240
  • HSCI1_000312
  • 109552-15-0 (PENTAHYDRATE)
  • 3-Amino-1-hydroxypropylidene-1,1-diphosphonate
  • 40391-99-9 (FREE ACID)
  • 57248-88-1 (DISODIUM SALT)
  • AIDS-088658
  • AIDS088658
  • Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-
  • NCGC00159433-02
  • NCGC00159433-03
  • (3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyl diphosphate synthase Starlite/ChEMBL References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Leishmania donovani farnesyl pyrophosphate synthase Starlite/ChEMBL References
Trypanosoma cruzi farnesyl pyrophosphate synthase Curated by TDR Targets No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative Curated by TDR Targets No references
Leishmania major farnesyl pyrophosphate synthase Curated by TDR Targets References
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Babesia bovis farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_127590 All targets in OG5_127590
Giardia lamblia Farnesyl diphosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative Get druggable targets OG5_127590 All targets in OG5_127590
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium vivax geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Cryptosporidium hominis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum putative farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii polyprenyl synthetase superfamily protein Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) polyprenyl synthetase Get druggable targets OG5_127590 All targets in OG5_127590
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium berghei geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus granulosus farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium yoelii farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Polyprenyl synthetase family protein Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium knowlesi geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0034 0.0034
Brugia malayi Cytochrome P450 family protein 0.0031 0.015 0.02
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0021 0.0077 0.0103
Brugia malayi Cation transporter family protein 0.0021 0.0077 0.0103
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0619 0.4725 1
Onchocerca volvulus 0.014 0.0997 0.2588
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0156 0.1125 0.1125
Onchocerca volvulus 0.0021 0.0077 0.0199
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0046 0.0062
Echinococcus multilocularis dna polymerase eta 0.0017 0.0046 0.0046
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0021 0.0077 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0278 0.0278
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0258 0.1683
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0278 0.0371
Leishmania major farnesyl pyrophosphate synthase 0.0619 0.4725 1
Leishmania major solanesyl-diphosphate synthase, putative 0.0156 0.1125 0.2327
Schistosoma mansoni nAChR subunit 0.0021 0.0077 0.0077
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0209 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.014 0.0997 0.1332
Loa Loa (eye worm) hypothetical protein 0.0038 0.0202 0.027
Onchocerca volvulus 0.0021 0.0077 0.0199
Mycobacterium tuberculosis Conserved protein 0.0048 0.0286 0.0538
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0021 0.0077 0.0103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0262
Echinococcus granulosus geminin 0.0363 0.273 0.273
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0021 0.0077 0.0103
Echinococcus granulosus intermediate filament protein 0.0033 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0027
Schistosoma mansoni kinase 0.0042 0.024 0.024
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.029 0.0584
Entamoeba histolytica hypothetical protein 0.0209 0.1534 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0046 0.0046
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0141 0.0141
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0083 0.0558 0.0558
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0141 0.0366
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0046 0.0062
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0558 0.0558
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0029 0.0133 0.0178
Schistosoma mansoni hypothetical protein 0.0048 0.0284 0.0284
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0034
Brugia malayi excitatory GABA receptor EXP-1A 0.0021 0.0077 0.0103
Echinococcus multilocularis dnaJ subfamily B 0.1298 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0131
Brugia malayi Polyprenyl synthetase family protein 0.0619 0.4725 0.631
Schistosoma mansoni glutathione synthetase 0.0156 0.1125 0.1125
Echinococcus granulosus laminin 0.0014 0.002 0.002
Brugia malayi polk-prov protein 0.0038 0.0202 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0202 0.042
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0133 0.0212
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0208 0.1527 0.3963
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0296 0.0484
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0133 0.0212
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0156 0.1125 0.2327
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.0286 0.0538
Entamoeba histolytica hypothetical protein 0.0209 0.1534 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0083 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0235 0.174 0.2324
Echinococcus multilocularis mothers against decapentaplegic 5 0.0066 0.0427 0.0427
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0048 0.0286 0.0452
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0021 0.0077 0.0077
Echinococcus multilocularis glycine receptor subunit beta 0.0021 0.0077 0.0077
Treponema pallidum octaprenyl-diphosphate synthase 0.0156 0.1125 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0066 0.0427 0.0427
Onchocerca volvulus 0.0021 0.0077 0.0199
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0021 0.0077 0.0077
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0046 0.0046
Brugia malayi hypothetical protein 0.0235 0.174 0.2324
Echinococcus multilocularis lamin dm0 0.0033 0.0164 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0202 0.042
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0077 0.0077
Trypanosoma cruzi polyprenyl synthase, putative 0.0156 0.1125 0.2327
Echinococcus multilocularis geminin 0.0363 0.273 0.273
Brugia malayi MH1 domain containing protein 0.0037 0.0196 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0558 0.1047
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0083 0.0558 0.0745
Brugia malayi RNA recognition motif domain containing protein 0.0363 0.2731 0.3647
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.002 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0558 0.1047
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0156 0.1125 0.5
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0021 0.0077 0.0103
Echinococcus multilocularis smad 0.0066 0.0427 0.0427
Schistosoma mansoni nAChR subunit 0.0021 0.0077 0.0077
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0156 0.1125 0.1503
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0077 0.0103
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0133 0.0273
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0077 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0363 0.2731 0.2731
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0034 0.0045
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0077 0.0103
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0141 0.0141
Brugia malayi MH2 domain containing protein 0.0975 0.7488 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0034 0.0034
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.002 0.0027
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0258 0.0478
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0046 0.0026
Schistosoma mansoni egf-like domain protein 0.0014 0.002 0.002
Onchocerca volvulus 0.0048 0.0284 0.0736
Onchocerca volvulus 0.0507 0.3853 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.029 0.029
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0021 0.0077 0.0077
Echinococcus granulosus Smad4 0.0066 0.0427 0.0427
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.002 0.0012
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0156 0.1125 0.2327
Schistosoma mansoni tar DNA-binding protein 0.0363 0.2731 0.2731
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0141 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.042 0.3174 0.6693
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0077 0.0077
Brugia malayi Cation transporter family protein 0.0021 0.0077 0.0103
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0156 0.1125 0.2327
Loa Loa (eye worm) polyprenyl synthetase 0.0156 0.1125 0.1503
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0156 0.1125 0.2375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0558 0.1047
Schistosoma mansoni transcription factor LCR-F1 0.0209 0.1534 0.1534
Brugia malayi RNA binding protein 0.0363 0.2731 0.3647
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0033 0.0033
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0077 0.0077
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0076 0.0153
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.002 0.0027
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0021 0.0077 0.0077
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0619 0.4725 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0164 0.0218
Echinococcus granulosus citrate lyase subunit beta protein 0.0048 0.0286 0.0286
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0021 0.0077 0.0103
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0156 0.1125 0.7337
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.1201 0.1201
Loa Loa (eye worm) ACC-1 protein 0.0021 0.0077 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Brugia malayi intermediate filament protein 0.0033 0.0164 0.0218
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Brugia malayi hypothetical protein 0.0507 0.3853 0.5146
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0619 0.4725 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0077 0.0077
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.029 0.047
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0066 0.0427 0.0427
Echinococcus multilocularis Smad4 0.0066 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0558 0.1047
Echinococcus multilocularis cpg binding protein 0.0096 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Echinococcus granulosus lamin dm0 0.0033 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0066 0.0427 0.057
Onchocerca volvulus 0.0021 0.0077 0.0199
Schistosoma mansoni tar DNA-binding protein 0.0363 0.2731 0.2731
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0156 0.1125 0.2327
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0156 0.1125 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0083 0.0558 0.1118
Leishmania major polyprenyl synthase, putative 0.0156 0.1125 0.2327
Onchocerca volvulus 0.0021 0.0077 0.0199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.0043
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0619 0.4725 0.4725
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0012 0.0012
Schistosoma mansoni Smad4 0.003 0.0141 0.0141
Brugia malayi serine/threonine-protein kinase plk-2 0.0083 0.0558 0.0745
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.1164 0.1164
Schistosoma mansoni cpg binding protein 0.0096 0.0659 0.0659
Schistosoma mansoni nAChR subunit 0.0021 0.0077 0.0077
Schistosoma mansoni intermediate filament proteins 0.0033 0.0164 0.0164
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0034 0.0045
Leishmania major DNA polymerase eta, putative 0.0017 0.0046 0.0026
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.1201 0.1603
Brugia malayi MH1 domain containing protein 0.0066 0.0427 0.057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.174 0.174
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0021 0.0077 0.0077
Echinococcus multilocularis musashi 0.0033 0.0164 0.0164
Echinococcus granulosus lamin 0.0033 0.0164 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0558 0.1047
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0021 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.0131
Onchocerca volvulus 0.0091 0.0619 0.1606
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0021 0.0077 0.0103
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0133 0.0212
Trypanosoma cruzi polyprenyl synthase, putative 0.0156 0.1125 0.2327
Loa Loa (eye worm) RNA binding protein 0.0363 0.2731 0.3647
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0076 0.0102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0127 0.0169
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0296 0.0559
Brugia malayi Polyprenyl synthetase family protein 0.0156 0.1125 0.1503
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0234 0.0487
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0034
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0156 0.1125 0.2257
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0034
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0619 0.4725 1
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0156 0.1125 0.7337
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0076 0.009
Schistosoma mansoni hypothetical protein 0.0209 0.1534 0.1534
Brugia malayi Cytochrome P450 family protein 0.0021 0.0076 0.0102
Trypanosoma cruzi polo-like protein kinase, putative 0.0083 0.0558 0.1118
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0296 0.0559
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0156 0.1125 0.1125
Trypanosoma cruzi hypothetical protein, conserved 0.042 0.3174 0.6693
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0619 0.4725 1
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0156 0.1125 0.1125
Echinococcus granulosus glycine receptor subunit beta 0.0021 0.0077 0.0077
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0046 0.0301
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0278 0.0278
Schistosoma mansoni Smad4 0.003 0.0141 0.0141
Trypanosoma brucei polo-like protein kinase 0.0083 0.0558 0.1174
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0133 0.0212
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0066 0.0427 0.0427
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0296 0.0473
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0021 0.0077 0.0077
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0619 0.4725 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0077 0.0103
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0156 0.1125 0.2327
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0258 0.0325
Schistosoma mansoni lamin 0.0033 0.0164 0.0164
Brugia malayi hypothetical protein 0.0018 0.0054 0.0072
Brugia malayi MH2 domain containing protein 0.0066 0.0427 0.057
Loa Loa (eye worm) hypothetical protein 0.0507 0.3853 0.5146
Echinococcus multilocularis lamin 0.0033 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0027
Schistosoma mansoni nAChR subunit 0.0021 0.0077 0.0077
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0076 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0296 0.0484
Brugia malayi CXXC zinc finger family protein 0.0091 0.0619 0.0826
Schistosoma mansoni lozenge 0.0064 0.0405 0.0405
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0021 0.0077 0.0077
Loa Loa (eye worm) TAR-binding protein 0.0363 0.2731 0.3647
Schistosoma mansoni nAChR subunit 0.0021 0.0077 0.0077
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.1201 0.1201
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0108 0.0159
Brugia malayi Smad1 0.0066 0.0427 0.057
Schistosoma mansoni smad1 5 8 and 0.0066 0.0427 0.0427
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0619 0.4725 1
Echinococcus granulosus cpg binding protein 0.0096 0.0659 0.0659
Brugia malayi MH1 domain containing protein 0.0066 0.0427 0.057
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0156 0.1125 0.1125
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0558 0.1047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0212
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0021 0.0077 0.0077
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0133 0.0212
Giardia lamblia Kinase, PLK 0.0083 0.0558 0.0975
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0086 0.0086
Echinococcus multilocularis glycine receptor subunit beta 0.0021 0.0077 0.0077
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.015 0.02
Mycobacterium ulcerans hypothetical protein 0.0048 0.0286 0.0452
Brugia malayi hypothetical protein 0.014 0.0997 0.1332
Brugia malayi Fibulin-1 precursor 0.0014 0.002 0.0027
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0046 0.0046
Trypanosoma brucei unspecified product 0.0042 0.0234 0.0487
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0077 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.0231 0.0344
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0296 0.0618
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0209 0.1534 0.1534
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0086 0.0086
Loa Loa (eye worm) runx1 0.0064 0.0405 0.0541
Entamoeba histolytica serine/threonine protein kinase, putative 0.0083 0.0558 0.3639
Trypanosoma brucei hypothetical protein, conserved 0.042 0.3174 0.6714
Schistosoma mansoni cpg binding protein 0.0096 0.0659 0.0659
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.002 0.0012
Schistosoma mansoni survival motor neuron protein 0.0048 0.0284 0.0284
Toxoplasma gondii histone lysine methyltransferase SET1 0.0177 0.1284 0.2695
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0046 0.0061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0037
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0164 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0133 0.0252
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0046 0.0061
Loa Loa (eye worm) LGC-31 protein 0.0021 0.0077 0.0103
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0021 0.0077 0.0077
Leishmania major cytochrome p450-like protein 0.0021 0.0076 0.009
Brugia malayi hypothetical protein 0.0209 0.1534 0.2048
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0027
Echinococcus multilocularis fibrillin 1 0.0014 0.002 0.002
Loa Loa (eye worm) nuclear factor I 0.0037 0.0196 0.0262
Brugia malayi N-terminal motif family protein 0.0208 0.1527 0.2039
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0156 0.1125 0.1503
Onchocerca volvulus Arrow homolog 0.0014 0.002 0.0053
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0164 0.0218
Echinococcus granulosus dna polymerase kappa 0.005 0.0296 0.0296
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0037
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.002 0.0027
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.0286 0.0538
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0034 0.0063
Brugia malayi MH2 domain containing protein 0.0066 0.0427 0.057
Loa Loa (eye worm) transcription factor SMAD2 0.0975 0.7488 1
Echinococcus multilocularis dna polymerase kappa 0.005 0.0296 0.0296
Brugia malayi MH1 domain containing protein 0.0037 0.0196 0.0262
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.002 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0141 0.0188
Schistosoma mansoni Smad4 0.0066 0.0427 0.0427
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0188
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.013 0.013
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0156 0.1125 0.2327
Schistosoma mansoni nAChR subunit 0.0021 0.0077 0.0077
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0021 0.0077 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0363 0.2731 0.2731
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0284 0.0379
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0156 0.1125 0.1125
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0156 0.1125 0.2257
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0086 0.0086
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Brugia malayi MH2 domain containing protein 0.003 0.0141 0.0188
Echinococcus granulosus tar DNA binding protein 0.0363 0.2731 0.2731
Loa Loa (eye worm) hypothetical protein 0.0208 0.1527 0.2039
Echinococcus multilocularis tar DNA binding protein 0.0363 0.2731 0.2731
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0619 0.4725 0.4725
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.029 0.047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0278 0.0278
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0021 0.0077 0.0103
Brugia malayi TAR-binding protein 0.0363 0.2731 0.3647
Entamoeba histolytica hypothetical protein 0.0209 0.1534 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0048 0.0286 0.0538
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0021 0.0077 0.0103
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0021 0.0077 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0296 0.0559
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0048 0.0286 0.0452
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.013 0.013
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0034 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0193 0.1413 0.1413
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0048 0.0286 0.0463
Loa Loa (eye worm) hypothetical protein 0.0033 0.0164 0.0218
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0086 0.0086
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0021 0.0077 0.0103
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0076 0.0102
Giardia lamblia Farnesyl diphosphate synthase 0.0619 0.4725 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0021 0.0077 0.0077
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0619 0.4725 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0077 0.0103
Echinococcus granulosus dna polymerase eta 0.0017 0.0046 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0278 0.0371
Schistosoma mansoni smad 0.0066 0.0427 0.0427
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0046 0.0026
Loa Loa (eye worm) ACC-1 protein 0.0021 0.0077 0.0103
Leishmania major hypothetical protein, conserved 0.0029 0.0133 0.0212
Echinococcus granulosus nAChR subunit 0.0021 0.0077 0.0077
Echinococcus granulosus TGF beta signal transducer SmadC 0.0066 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0363 0.2731 0.2731
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.002 0.0027
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0619 0.0826
Brugia malayi Cytochrome P450 family protein 0.0021 0.0076 0.0102
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0046 0.0089
Loa Loa (eye worm) hypothetical protein 0.0507 0.3853 0.5146
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0619 0.4725 1
Trichomonas vaginalis CAMK family protein kinase 0.0041 0.0231 0.0344
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0156 0.1125 0.2358
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0619 0.4725 0.4725
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Echinococcus multilocularis Tolloid protein 1 0.0014 0.002 0.002
Schistosoma mansoni hypothetical protein 0.1298 1 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0083 0.0558 0.1118
Loa Loa (eye worm) acetyltransferase 0.0166 0.1201 0.1603
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0076 0.0102
Echinococcus granulosus Tolloid protein 1 0.0014 0.002 0.002
Schistosoma mansoni smad1 5 8 and 0.0066 0.0427 0.0427
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0156 0.1125 0.7337
Brugia malayi hypothetical protein 0.0029 0.0133 0.0178
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0156 0.1125 0.2327
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0278 0.0278
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0558 0.1047
Onchocerca volvulus Serine\/threonine kinase homolog 0.0083 0.0558 0.1449
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.174 0.174
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0077 0.0103
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.029 0.0545
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0108 0.0221
Entamoeba histolytica hypothetical protein 0.0209 0.1534 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0034 0.0045
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0077 0.0103
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0048 0.0286 0.0452
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0021 0.0077 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0296 0.0559
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0077 0.0103
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0296 0.0618
Onchocerca volvulus 0.0021 0.0077 0.0199
Loa Loa (eye worm) MH2 domain-containing protein 0.0975 0.7488 1
Onchocerca volvulus 0.0033 0.0164 0.0424
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0041
Loa Loa (eye worm) Smad1 0.0066 0.0427 0.057
Brugia malayi Cation transporter family protein 0.0021 0.0077 0.0103
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0619 0.4725 1
Schistosoma mansoni cpg binding protein 0.0091 0.0619 0.0619
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0296 0.0473
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.0286 0.0538
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0021 0.0077 0.0077
Onchocerca volvulus 0.0033 0.0164 0.0424
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Schistosoma mansoni DNA polymerase eta 0.0017 0.0046 0.0046
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0021 0.0077 0.0103
Echinococcus granulosus smad 0.0066 0.0427 0.0427
Echinococcus multilocularis citrate lyase subunit beta protein 0.0048 0.0286 0.0286
Loa Loa (eye worm) histone methyltransferase 0.0028 0.013 0.0173
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.0077 0.0103
Schistosoma mansoni smad 0.003 0.0141 0.0141
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0156 0.1125 0.5
Schistosoma mansoni smad1 5 8 and 0.0066 0.0427 0.0427
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0021 0.0077 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0296 0.0618
Schistosoma mansoni lamin 0.0033 0.0164 0.0164
Schistosoma mansoni nAChR subunit 0.0021 0.0077 0.0077
Echinococcus granulosus glycine receptor subunit beta 0.0021 0.0077 0.0077
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0021 0.0077 0.0103
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0021 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0363 0.273 0.273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0278 0.0278
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.0077 0.0077
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0156 0.1125 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0363 0.2731 0.3647
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0156 0.1125 0.1125
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0021 0.0077 0.0077
Loa Loa (eye worm) polyprenyl synthetase 0.0619 0.4725 0.631
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0108 0.0159
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0046 0.0062
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0156 0.1125 0.2327
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0021 0.0077 0.0077
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.0077 0.0077
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.042 0.3174 0.6693
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.029 0.0584
Mycobacterium ulcerans hypothetical protein 0.0048 0.0286 0.0452
Echinococcus multilocularis Protein lozenge 0.0064 0.0405 0.0405
Schistosoma mansoni trans-prenyltransferase 0.0156 0.1125 0.1125
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0141 0.0188
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0427 0.057
Schistosoma mansoni hypothetical protein 0.0363 0.273 0.273
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0619 0.4725 1
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0619 0.4725 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0046 0.0046
Echinococcus multilocularis laminin 0.0014 0.002 0.002
Onchocerca volvulus Putative nachr subunit 0.0021 0.0077 0.0199
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0141 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0278 0.0278
Leishmania major DNA polymerase kappa, putative 0.0025 0.0108 0.0159
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0103
Echinococcus multilocularis nAChR subunit 0.0021 0.0077 0.0077
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0156 0.1125 0.1125
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.0077 0.0077

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) 0 Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as oriT ssDNA cleavage at 200 nM ChEMBL. 17630285
Control (ADMET) = 55.7 % Inhibition of HAP dissolution was determined in 3.87 mM calcium and 2.32 mM phosphate metastable solution at 0.24 mM concentration *: p<0.05 ChEMBL. 11020278
Control (ADMET) = 79.4 % Inhibition of HAP dissolution was determined in 3.87 mM calcium and 2.32 mM phosphate metastable solution at 0.048 mM concentration *: p<0.05 ChEMBL. 11020278
EC50 (functional) > 10 mM Inhibition of conjugate DNA transfer between tetracycline-resistant F plasmid positive Escherichia coli JS10 to streptomycin-resistant F plasmid deficient Escherichia coli JS4 ChEMBL. 17630285
EC50 (functional) > 10 mM Cytotoxicity against tetracycline-resistant F plasmid positive Escherichia coli JS10 ChEMBL. 17630285
EC50 (functional) > 10 mM Cytotoxicity against streptomycin-resistant F plasmid deficient Escherichia coli JS4 ChEMBL. 17630285
EC50 (functional) > 10 mM Inhibition of conjugate DNA transfer between tetracycline-resistant F plasmid positive Escherichia coli JS10 to streptomycin-resistant F plasmid deficient Escherichia coli JS4 ChEMBL. 17630285
EC50 (functional) > 10 mM Cytotoxicity against tetracycline-resistant F plasmid positive Escherichia coli JS10 ChEMBL. 17630285
EC50 (functional) > 10 mM Cytotoxicity against streptomycin-resistant F plasmid deficient Escherichia coli JS4 ChEMBL. 17630285
EC50 (functional) = 5.66 uM Effective concentration to activate gammadelta T cells ChEMBL. 12383012
EC50 (functional) = 43 uM Effective concentration of the compound against human Gamma delta T cells ChEMBL. 15828834
ED100 (functional) = 11 mg kg-1 Effective dose for increased serum urea level rats after a treatment period of 1 h in renal tolerability model ChEMBL. 12166945
ED50 (functional) = 7.1 ug kg-1 Effective dose for increased cancellous bone area in young interact rats after a treatment period of 10 days ChEMBL. 12166945
ED50 (functional) = 22.7 ug kg-1 Effective dose for increased cancellous bone calcium in young interact rats after a treatment period of 10 days ChEMBL. 12166945
ED50 (functional) = 61 ug kg-1 Effective dose after subcutaneous administration to TPTX rats for 50% reduction of hypercalcemia ChEMBL. 12166945
ED50 (functional) = 210 ug kg-1 Effective dose for increased cancellous bone hydroxy proline in young interact rats after a treatment period of 10 days ChEMBL. 12166945
ED50 (functional) = 390 ug kg-1 Effective dose for increased adiographic bone density in young interact rats after a treatment period of 10 days ChEMBL. 12166945
F (ADMET) = 0.44 % Bioavailability by the ratios of 14C p.o. /14C i.v. accumulated in bone at 24 hr (dose 10 mg/kg p.o.) ChEMBL. 11020278
F (ADMET) = 1.74 % Bioavailability by the ratios of 14C p.o. /14C i.v. accumulated in urine at 24 hr (dose 10 mg/kg p.o.) ChEMBL. 11020278
IC50 (functional) Inhibition of L. donovani(Amastigotes) strain MHOM/ET/67/L82 maintained in pathogen free spleen from female golden hamsters; toxic ChEMBL. 11300872
IC50 (binding) = -5.73 Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) ChEMBL. 14613320
IC50 (functional) < -4 Log IC50 brucei Trypomastigotes ChEMBL. 12086478
IC50 (binding) = 3.7 Inhibition of human recombinant geranylgeranyl diphosphate synthase ChEMBL. 18800762
IC50 (functional) 0 Inhibition of L. donovani(Amastigotes) strain MHOM/ET/67/L82 maintained in pathogen free spleen from female golden hamsters; toxic ChEMBL. 11300872
IC50 (binding) = 200 nM Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting ChEMBL. 21780776
IC50 (binding) = 353.2 nM Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins ChEMBL. 18327899
IC50 (binding) = 353.2 nM Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins ChEMBL. 18327899
IC50 (binding) = 1932 nM Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 ChEMBL. 18327899
IC50 (binding) = 1932 nM Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 ChEMBL. 18327899
IC50 (functional) = 0.009 uM Inhibitory activity of compound on p24 production in peripheral blood mononuclear cells infected with HIV strain HTLV IIIB wild type. ChEMBL. 10386942
IC50 (functional) = 0.2 uM Inhibition of bone resorption in the calvaria assay of mouse ChEMBL. 12166945
IC50 (binding) = 0.2 uM Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzyme ChEMBL. 12014956
IC50 (binding) = 0.2 uM Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzyme ChEMBL. 12014956
IC50 (functional) = 0.2 uM Inhibition of bone resorption in the calvaria assay of mouse ChEMBL. 12166945
IC50 (functional) = 0.4 uM Inhibitory activity of compound on p24 production in peripheral blood mononuclear cells infected with HIV strain RT-MDR. ChEMBL. 10386942
IC50 (binding) = 1.5 uM Inhibition of purified recombinant HIV-1 reverse transcriptase ChEMBL. 10386942
IC50 (functional) = 1.6 uM In vitro inhibitory concentration against bone resorption in 17 day old fetal mouse metatarsals ChEMBL. 15828834
IC50 (functional) = 1.6 uM In vitro inhibitory concentration against bone resorption in 17 day old fetal mouse metatarsals ChEMBL. 15828834
IC50 (binding) = 1.9 uM Inhibitory activity against farnesyl Pyrophosphate Synthase was determined ChEMBL. 14613320
IC50 (binding) = 1.9 uM Inhibitory activity against farnesyl Pyrophosphate Synthase was determined ChEMBL. 14613320
IC50 (functional) = 33.6 uM Antiproliferative activity against rat 13762 cell line ChEMBL. 16970405
IC50 (functional) = 35.6 uM Inhibition of T. gondii tachyzoites in human foreskin fibroblast monolayer(DMEM with 10%fetal calf serum) ChEMBL. 11300872
IC50 (functional) = 35.6 uM Inhibition of T. gondii tachyzoites in human foreskin fibroblast monolayer(DMEM with 10%fetal calf serum) ChEMBL. 11300872
IC50 (functional) = 38 uM In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) ChEMBL. 15857119
IC50 (functional) = 50 uM Inhibitory activity of compound on p24 production in peripheral blood mononuclear cells infected with HIV strain A17. ChEMBL. 10386942
IC50 (functional) = 60 uM Inhibition of T. cruzi Amastigotes was determined in Vero cells culture and fetal calf serum ChEMBL. 11300872
IC50 (functional) = 60 uM Inhibition of T. cruzi Amastigotes was determined in Vero cells culture and fetal calf serum ChEMBL. 11300872
IC50 (functional) = 62 uM Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release ChEMBL. 14711309
IC50 (functional) = 65 uM In vitro antiparasitic activity against T. cruzi (amastigotes) ChEMBL. 11277521
IC50 (functional) = 65 uM In vitro antiparasitic activity against T. cruzi (amastigotes) ChEMBL. 11277521
IC50 (functional) = 71.8 uM Antiproliferative activity against human NCI-H460 cell line by MTT assay ChEMBL. 16970405
IC50 (functional) = 71.8 uM Antiproliferative activity against human NCI-H460 cell line by MTT assay ChEMBL. 16970405
IC50 (functional) > 100 uM Inhibitory activity of compound on p24 production in peripheral blood mononuclear cells infected with HIV strain A17 variant. ChEMBL. 10386942
IC50 (functional) > 100 uM In vitro growth inhibition of blood-stream-form Trypanosoma brucei rhodesiense Trypomastigotes ChEMBL. 12086478
IC50 (functional) = 100 uM Inhibition of mineralization in the calvaria assay of mouse ChEMBL. 12166945
IC50 (functional) = 100 uM Inhibition of mineralization in the calvaria assay of mouse ChEMBL. 12166945
IC50 (functional) > 100 uM In vitro growth inhibition of blood-stream-form Trypanosoma brucei rhodesiense Trypomastigotes ChEMBL. 12086478
IC50 (functional) = 141 uM Antiproliferative activity against human MCF7 cell line by MTT assay ChEMBL. 16970405
IC50 (functional) = 141 uM Antiproliferative activity against human MCF7 cell line by MTT assay ChEMBL. 16970405
IC50 (functional) = 167 uM Ability to inhibit growth of D. discoideum. ChEMBL. 12086477
IC50 (functional) = 167 uM Inhibitory concentration of the compound against Dictyostelium discoideum cell growth ChEMBL. 15828834
IC50 (functional) = 167 uM Ability to inhibit growth of D. discoideum. ChEMBL. 12086477
IC50 (functional) = 167 uM Inhibitory concentration of the compound against Dictyostelium discoideum cell growth ChEMBL. 15828834
IC50 (functional) = 177 uM Inhibition of T. rhodesiense (strain STIB900) was determined using blood stream from trypomastigotes ChEMBL. 11300872
IC50 (functional) = 177 uM Inhibition of T. rhodesiense (strain STIB900) was determined using blood stream from trypomastigotes ChEMBL. 11300872
IC50 (binding) = 180 uM Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase). ChEMBL. 12014956
IC50 (binding) = 180 uM Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase). ChEMBL. 12014956
IC50 (binding) = 181.97 uM Inhibition of human recombinant geranylgeranyl diphosphate synthase ChEMBL. 18800762
IC50 (functional) > 200 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (functional) > 200 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) > 200 uM Inhibition of P. falciparum (intraerythrocytic stages) strain 3D7 ChEMBL. 11300872
IC50 (functional) > 200 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (functional) > 200 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) > 200 uM Inhibition of P. falciparum (intraerythrocytic stages) strain 3D7 ChEMBL. 11300872
IC50 (functional) = 200 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
IC50 (functional) = 200 uM Antimicrobial activity against Entamoeba histolytica ChEMBL. 20185316
IC50 (functional) > 200 uM Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR ChEMBL. 20457823
IC50 (functional) = 408 uM Antiproliferative activity against human SF-268 cell line by MTT assay ChEMBL. 16970405
IC50 (functional) = 408 uM Antiproliferative activity against human SF-268 cell line by MTT assay ChEMBL. 16970405
IC50 (functional) = 941 uM Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL ChEMBL. 14711309
Inhibition (ADMET) Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins ChEMBL. 22931300
Inhibition (ADMET) Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins ChEMBL. 22931300
Inhibition (ADMET) Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins ChEMBL. 22931300
Inhibition (ADMET) Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins ChEMBL. 22931300
Inhibition (ADMET) Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins ChEMBL. 22931300
Inhibition (ADMET) Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins ChEMBL. 22931300
Initial concentration (ADMET) = 46.9 % Inhibition of HAP formation , by the compound (1.0 mM) absorbed , was obtained in vitro studies.*: p<0.05 ChEMBL. 11020278
Initial concentration (ADMET) = 63.8 % Inhibition of HAP formation, by the compound (0.1 mM) absorbed , was obtained in vitro studies.*: p<0.05 ChEMBL. 11020278
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
Ki (binding) = 55.9 nM Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins ChEMBL. 18327899
Ki (binding) = 55.9 nM Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins ChEMBL. 18327899
Ki (binding) = 190 nM Binding affinity towards Farnesyl diphosphate synthase from leishmania major ChEMBL. 15828834
Ki (binding) = 190 nM Binding affinity towards Farnesyl diphosphate synthase from leishmania major ChEMBL. 15828834
Ki (binding) = 331.4 nM Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 ChEMBL. 18327899
Ki (binding) = 331.4 nM Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 ChEMBL. 18327899
Ki (binding) = 0.18 uM Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand ChEMBL. 14613320
Ki (binding) = 0.18 uM Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand ChEMBL. 14613320
Ki (binding) = 50.6 uM Inhibition of hypoxanthine-guanine phosphoribosyltransferase (TcHPRT) ChEMBL. 15357980
LD50 (ADMET) = 156 uM 50% lethal dose for inhibition of KB cells growth ChEMBL. 12086478
LD50 (ADMET) = 156 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
LD50 (ADMET) = 156 uM 50% lethal dose for inhibition of KB cells growth ChEMBL. 12086478
LD50 (ADMET) = 156 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
LD50 (functional) = 156 uM Lethal dose required to inhibit the growth of human KB (nasopharyngeal carcinoma) cell line ChEMBL. 15857119
LED (functional) = 0.03 mg kg-1 Inhibition of bone resorption in rat assessed as phosphate ChEMBL. 18327899
LED (functional) = 0.03 mgP kg-1 Bone resorption activity in rats. ChEMBL. 12086477
Log IC50 (functional) = 3.03 pIC50 value for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL ChEMBL. 14711309
Log IC50 (functional) < 4 Log IC50 brucei Trypomastigotes ChEMBL. 12086478
Log IC50 (functional) = 4.21 pIC50 value for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release ChEMBL. 14711309
Log IC50 (binding) = 5.73 Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) ChEMBL. 14613320
NOL (functional) = 0.1 mg kg-1 Effective dose for increased urinary excretion of MDH in rats after a treatment period of 14 days in renal tolerability model ChEMBL. 12166945
NOL (functional) = 10 mM Effective dose for increased mucosal permeability of perfused ileal loop in rats after a treatment period of 2 hr in intestinal tolerability model ChEMBL. 12166945
Permeability (ADMET) = 0.00000004 cm s-1 Basolateral to apical fluxes of the compound across Caco-2 cell monolayers at 37 degree celsius was studied. ChEMBL. 11020278
Permeability (ADMET) = 0.00000004 cm s-1 Basolateral to apical fluxes of the compound across Caco-2 cell monolayers at 37 degree celsius was studied. ChEMBL. 11020278
Permeability (ADMET) = 0.00000005 cm s-1 Apical to basolateral fluxes of the compound across Caco-2 cell monolayers at 37 degree celsius was studied. ChEMBL. 11020278
Permeability (ADMET) = 0.00000005 cm s-1 Apical to basolateral fluxes of the compound across Caco-2 cell monolayers at 37 degree celsius was studied. ChEMBL. 11020278
Potency (functional) 4.2562 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.3359 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Ratio (functional) = 500 Ratio of calvaria mineralization to calvaria bone resorption ChEMBL. 12166945
Reduction (functional) = 5 % Mean reduction in parasitaemia of Plasmodium berghei ANKA suppressive test in mice (in vivo) at 25 mg/kg scheduled for 4 days ChEMBL. 14695831
Reduction (functional) = 5 % Mean reduction in parasitaemia of Plasmodium berghei ANKA suppressive test in mice (in vivo) at 25 mg/kg scheduled for 4 days ChEMBL. 14695831
T1/2 (ADMET) = 1 hr Half life in human plasma at 1 mg/kg, iv ChEMBL. 25893039
Therapeutic ratio (functional) = 1.2 Therapeutic ratio comparing nephrotoxic potential versus bone antiresorptive potency ( reciprocal of ED50 (TPTX assay) / the total urinary malate dehydrogenase excretion) ChEMBL. 12166945
TI (ADMET) < 2 Therapeutic index measured as the ratio of LD50 (KB cells) to IC50 (T.b. rhodesiense) ChEMBL. 12086478

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 12166945
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania donovani 22228  
Annotator: aaronjr@u.washington.edu Comment: Drug: Bisphosphonates; Drug: 109552-15-0; Drug: (Alendronate) 129318-43-0. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, homologue LmjF22.1360) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions); Q0GKD7_LEIDO; References: 11850291
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania donovani 22228  
Annotator: aaronjr@u.washington.edu Comment: Drug: Bisphosphonates; Drug: 109552-15-0; Drug: (Alendronate) 129318-43-0. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, homologue LmjF22.1360) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions); Q0GKD7_LEIDO; References: 11850291
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania amazonensis 22228  
Annotator: aaronjr@u.washington.edu Comment: Drug: Bisphosphonates; Drug: 109552-15-0. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, homologue LmjF22.1360) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions); Q0GKD7_LEIDO; References: 12089677
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22228  
Annotator: aaronjr@u.washington.edu Comment: Drug: Bisphosphonates; Drug: 109552-15-0. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, homologue LmjF22.1360) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions); Q0GKD7_LEIDO; References: 12089677
growth (GO:0040007) decreased (PATO:0000468) amastigote (BTO:0000062) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 46630  
Annotator: millerja@u.washington.edu Comment: Compound structure in Scheme 1 of referenced publication References: 11300872 15164969 16143525
growth (GO:0040007) decreased (PATO:0000468) amastigote (BTO:0000062) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 51685  
Annotator: millerja@u.washington.edu Comment: Compound structure in Scheme 1 of referenced publication References: 11300872 15164969 16143525
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 46630  
Annotator: millerja@u.washington.edu Comment: References: 11435429 16143525
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 51685  
Annotator: millerja@u.washington.edu Comment: References: 11435429 16143525

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

25 literature references were collected for this gene.

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