Detailed information for compound 342983

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.444 | Formula: C18H31NO2
  • H donors: 3 H acceptors: 2 LogP: 4.26 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCc1ccc(cc1)CCC(CO)(O)N
  • InChi: 1S/C18H31NO2/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)13-14-18(19,21)15-20/h9-12,20-21H,2-8,13-15,19H2,1H3
  • InChiKey: BKKVDWZESDOMLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0024 0.0069 0.0069
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0273 0.0273
Echinococcus multilocularis ribonuclease H1 0.0463 0.2616 0.5133
Loa Loa (eye worm) glutamate receptor 0.0075 0.0367 0.1122
Schistosoma mansoni hypothetical protein 0.0039 0.016 0.016
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0039 0.016 0.0126
Schistosoma mansoni ap endonuclease 0.0022 0.0057 0.0057
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0049 0.0215 0.0658
Loa Loa (eye worm) hypothetical protein 0.0235 0.1293 0.3958
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0173 0.0933 0.2857
Brugia malayi reverse transcriptase 0.0039 0.016 0.0489
Brugia malayi reverse transcriptase 0.0039 0.016 0.0489
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0256 0.062
Toxoplasma gondii ribonuclease HI protein 0.0463 0.2616 1
Leishmania major ribonuclease H1, putative 0.0463 0.2616 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0575 0.3267 1
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0039 0.016 0.0401
Echinococcus granulosus nmda type glutamate receptor 0.0018 0.0036 0.0118
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0232 0.0232
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.016 0.0313
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0039 0.016 0.0401
Schistosoma mansoni hypothetical protein 0.0025 0.0079 0.0079
Brugia malayi hypothetical protein 0.0039 0.0156 0.0478
Trichomonas vaginalis glucosylceramidase, putative 0.0575 0.3267 1
Echinococcus multilocularis muscleblind protein 0.0161 0.0864 0.1695
Brugia malayi Zinc knuckle family protein 0.0039 0.016 0.0489
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.212 0.6427
Brugia malayi Receptor family ligand binding region containing protein 0.0049 0.0215 0.0658
Brugia malayi N-terminal motif family protein 0.0135 0.0715 0.2189
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0256 0.0861
Schistosoma mansoni hypothetical protein 0.0319 0.1781 0.1781
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0256 0.0861
Treponema pallidum ribonuclease H (rnhA) 0.0463 0.2616 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0025 0.0076 0.0253
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0076 0.0233
Echinococcus granulosus GPCR family 3 C terminal 0.0031 0.0111 0.0368
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0337 0.0337
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0045 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.212 0.6427
Schistosoma mansoni phosphoglucomutase 0.0463 0.2616 0.2616
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0057 0.0175
Schistosoma mansoni hypothetical protein 0.0051 0.023 0.023
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0256 0.0784
Schistosoma mansoni tyrosine kinase 0.0025 0.0076 0.0076
Echinococcus multilocularis glutamate receptor 2 0.0018 0.0036 0.007
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0682 0.2089
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0682 0.2089
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0337 0.0661
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0337 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.089 0.5097 1
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0232 0.0709
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0109
Echinococcus multilocularis muscleblind protein 1 0.0161 0.0864 0.1695
Trichomonas vaginalis glucosylceramidase, putative 0.0575 0.3267 1
Echinococcus multilocularis tyrosine kinase 0.0025 0.0076 0.015
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0076 0.0233
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0256 0.062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0171 0.0568
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0256 0.0502
Brugia malayi reverse transcriptase 0.0039 0.016 0.0489
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0018 0.0036 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0237 0.0237
Echinococcus multilocularis neuropeptide s receptor 0.0532 0.3018 0.5921
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0337 0.1093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0045 0.0045
Loa Loa (eye worm) TK/ALK protein kinase 0.0436 0.2461 0.7534
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0018 0.0036 0.007
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0018 0.0036 0.007
Brugia malayi Bromodomain containing protein 0.0086 0.0432 0.1323
Echinococcus multilocularis neuropeptide receptor A26 0.0532 0.3018 0.5921
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.1139 0.2235
Echinococcus multilocularis nmda type glutamate receptor 0.0018 0.0036 0.007
Giardia lamblia Ribonuclease H 0.0463 0.2616 1
Brugia malayi RNase H family protein 0.0463 0.2616 0.8009
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0039 0.016 0.0529
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0337 1
Brugia malayi Bromodomain containing protein 0.0044 0.0187 0.0573
Trypanosoma brucei ribonuclease H1 0.0463 0.2616 0.2592
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Echinococcus granulosus MAM 0.0051 0.023 0.0761
Trichomonas vaginalis glucosylceramidase, putative 0.0575 0.3267 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0082 0.0082
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0039 0.016 0.0126
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0057 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0256 0.0861
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.033 0.1093
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0256 0.062
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0045 0.0089
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0256 0.0861
Loa Loa (eye worm) hypothetical protein 0.0051 0.023 0.0703
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0039 0.016 0.0529
Brugia malayi hypothetical protein 0.0039 0.016 0.0489
Brugia malayi MAP kinase sur-1 0.0056 0.0256 0.0784
Echinococcus granulosus neuropeptide receptor A26 0.0532 0.3018 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Echinococcus granulosus atrial natriuretic peptide receptor 0.0018 0.0036 0.0118
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0273 0.0905
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0039 0.016 0.0529
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0045 0.015
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0109
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0256 0.0502
Giardia lamblia Reverse transcriptase/endonuclease 0.0039 0.016 0.0401
Loa Loa (eye worm) hypothetical protein 0.0161 0.0864 0.2644
Echinococcus granulosus KRAB A domain containing protein 0.0039 0.016 0.0529
Onchocerca volvulus 0.0052 0.0232 0.076
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0018 0.0036 0.0109
Trypanosoma brucei ingi protein (ORF1) 0.0502 0.2845 0.282
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0076 0.0233
Trichomonas vaginalis reverse transcriptases, putative 0.0039 0.016 0.0319
Loa Loa (eye worm) hypothetical protein 0.0037 0.0148 0.0453
Loa Loa (eye worm) hypothetical protein 0.0052 0.0232 0.0709
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0273 0.0836
Loa Loa (eye worm) hypothetical protein 0.0135 0.0715 0.2189
Brugia malayi RNase H family protein 0.0463 0.2616 0.8009
Echinococcus granulosus tyrosine kinase 0.0025 0.0076 0.0253
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0018 0.0036 0.0118
Trypanosoma cruzi ribonuclease H1, putative 0.0463 0.2616 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0109
Trypanosoma brucei ingi protein (ORF1) 0.0502 0.2845 0.282
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Trypanosoma cruzi extracellular receptor, putative 0.0018 0.0036 0.0007
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0256 0.0778
Entamoeba histolytica hypothetical protein 0.0039 0.0156 1
Schistosoma mansoni phosphoglucomutase 0.0463 0.2616 0.2616
Loa Loa (eye worm) glutamate receptor 0.0191 0.1037 0.3176
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0156 0.0306
Loa Loa (eye worm) hypothetical protein 0.0047 0.0203 0.0623
Schistosoma mansoni hypothetical protein 0.0039 0.016 0.016
Entamoeba histolytica hypothetical protein 0.0039 0.0156 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Schistosoma mansoni metabotropic glutamate receptor 0.016 0.0858 0.0858
Entamoeba histolytica hypothetical protein 0.0039 0.0156 1
Brugia malayi hypothetical protein 0.0018 0.0036 0.0109
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0057 0.0023
Brugia malayi RNase H family protein 0.0463 0.2616 0.8009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0337 0.1116
Brugia malayi hypothetical protein 0.0039 0.016 0.0489
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0037 0.0148 0.0453
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0109
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.016 0.0529
Entamoeba histolytica hypothetical protein 0.0039 0.0156 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0256 0.0861
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0237 0.0725
Echinococcus granulosus muscleblind protein 0.0161 0.0864 0.2862
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.2238 0.6794
Schistosoma mansoni phosphoglucomutase 0.0463 0.2616 0.2616
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0057 0.0091
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0237 0.0785
Brugia malayi Calcitonin receptor-like protein seb-1 0.0037 0.0148 0.0453
Brugia malayi MH2 domain containing protein 0.0129 0.0682 0.2089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0057 0.0189
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0232 0.0232
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0337 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0575 0.3267 1
Trypanosoma brucei unspecified product 0.0502 0.2845 0.282
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0217 0.1189 0.1189
Schistosoma mansoni ap endonuclease 0.0022 0.0057 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0575 0.3267 1
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0039 0.016 0.0126
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0232 0.0767
Onchocerca volvulus 0.0051 0.023 0.0752
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0237 0.0465
Loa Loa (eye worm) hypothetical protein 0.0049 0.0216 0.0662
Trypanosoma brucei protein kinase, putative 0.0056 0.0256 0.0223
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0018 0.0036 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0256 0.0256
Echinococcus granulosus neuropeptide s receptor 0.0532 0.3018 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0057 0.0091
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0057 0.1787
Brugia malayi hypothetical protein 0.0039 0.016 0.0489
Schistosoma mansoni hypothetical protein 0.0031 0.0111 0.0111
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0018 0.0036 0.007
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0049 0.0151
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0031 0.0111 0.034
Onchocerca volvulus 0.0039 0.016 0.0481
Loa Loa (eye worm) hypothetical protein 0.0044 0.0188 0.0574
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0273 0.0536
Echinococcus multilocularis MAM 0.0051 0.023 0.0451
Onchocerca volvulus Poor gastrulation protein homolog 0.0031 0.0111 0.0293
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.212 0.6427
Mycobacterium tuberculosis Possible maturase 0.0039 0.016 0.3665
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0057 0.0175
Schistosoma mansoni protein kinase 0.0039 0.016 0.016
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0045 0.0045
Schistosoma mansoni tyrosine kinase 0.0025 0.0076 0.0076
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0463 0.2616 1
Trypanosoma brucei RNA helicase, putative 0.1735 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0018 0.0036 0.0118
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0135 0.0715 0.2634
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0069 0.0212
Schistosoma mansoni bromodomain containing protein 0.0073 0.0354 0.0354
Echinococcus granulosus glutamate receptor 2 0.0018 0.0036 0.0118
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0243
Loa Loa (eye worm) hypothetical protein 0.0081 0.0404 0.1235
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0256 0.0849
Schistosoma mansoni hypothetical protein 0.0039 0.0156 0.0156
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0018 0.0036 0.0118
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Schistosoma mansoni hypothetical protein 0.0051 0.023 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.016 0.0488
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0232 0.0454
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.212 0.6427
Brugia malayi Protein kinase domain containing protein 0.0436 0.2462 0.7537
Echinococcus multilocularis metabotropic glutamate receptor 2 0.016 0.0858 0.1683
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0039 0.016 0.0401
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0039 0.016 0.0319
Echinococcus granulosus metabotropic glutamate receptor 5 0.0235 0.1293 0.4284
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0256 0.0849
Trichomonas vaginalis glucosylceramidase, putative 0.0575 0.3267 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0171 0.0336
Trichomonas vaginalis glucosylceramidase, putative 0.0575 0.3267 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0025 0.0076 0.0158
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0039 0.016 0.0401
Echinococcus granulosus metabotropic glutamate receptor 2 0.016 0.0858 0.2843
Brugia malayi hypothetical protein 0.0051 0.023 0.0703
Echinococcus granulosus ribonuclease H1 0.0463 0.2616 0.8669
Brugia malayi latrophilin 2 splice variant baaae 0.0025 0.0079 0.0243
Onchocerca volvulus 0.0025 0.0076 0.0158
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0273 0.0905
Brugia malayi Guanylyl cyclase protein 23 0.0025 0.0076 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.212 0.6427
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0163 0.0163
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0039 0.016 0.0481
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0232 0.0232
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Leishmania major extracellular receptor, putative 0.0018 0.0036 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0057 0.0112
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0139
Echinococcus multilocularis zinc finger protein 0.0023 0.0062 0.0122
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0082 0.0161
Brugia malayi mbt repeat family protein 0.0052 0.0232 0.0709
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0232 0.076
Loa Loa (eye worm) hypothetical protein 0.0059 0.0273 0.0836
Schistosoma mansoni zinc finger protein 0.0018 0.0034 0.0034
Echinococcus multilocularis GPCR, family 3, C terminal 0.0031 0.0111 0.0218
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0031 0.0111 0.0293
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0045 0.0045
Trichomonas vaginalis reverse transcriptases, putative 0.0039 0.016 0.0319
Brugia malayi Metabotropic glutamate receptor precursor. 0.0191 0.1037 0.3176
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0109
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0337 0.0337
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0049 0.0215 0.0658
Onchocerca volvulus Ribonuclease H1 homolog 0.0463 0.2616 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0256 0.0778
Onchocerca volvulus Glucosylceramidase homolog 0.0377 0.212 0.8077
Brugia malayi Zinc knuckle family protein 0.0039 0.016 0.0489
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0232 0.0767
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0273 0.0536
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0018 0.0036 0.007
Trypanosoma brucei hypothetical protein, conserved 0.0502 0.2845 0.282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0233
Trypanosoma cruzi ribonuclease H1, putative 0.0463 0.2616 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0082 0.0272
Loa Loa (eye worm) hypothetical protein 0.0378 0.2123 0.6497
Schistosoma mansoni metabotropic glutamate receptor 0.0093 0.0471 0.0471
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0156 0.0517
Onchocerca volvulus 0.0039 0.016 0.0481
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0235 0.1293 0.2537
Schistosoma mansoni glutamate receptor NMDA 0.0018 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.212 0.6427
Schistosoma mansoni hypothetical protein 0.0018 0.0034 0.0034
Echinococcus multilocularis receptor type guanylyl cyclase 0.0025 0.0076 0.015
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0057 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0237 0.0237
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.033 0.0647
Echinococcus multilocularis glutamate receptor 2 0.0018 0.0036 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0337 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0237 0.0785
Brugia malayi mbt repeat family protein 0.0052 0.0232 0.0709
Loa Loa (eye worm) MBCTL1 0.0059 0.0273 0.0836
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Brugia malayi hypothetical protein 0.0039 0.016 0.0489
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0045 0.0089
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0337 0.1174
Brugia malayi Muscleblind-like protein 0.0161 0.0864 0.2644
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0502 0.2845 0.282
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0237 0.0725
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0256 0.0223
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.016 0.0313
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0057 0.0091
Trichomonas vaginalis ribonuclease H1, putative 0.0463 0.2616 0.7973
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0039 0.016 0.0529
Loa Loa (eye worm) hypothetical protein 0.0161 0.0864 0.2644
Brugia malayi PHD-finger family protein 0.0029 0.0098 0.0299
Loa Loa (eye worm) hypothetical protein 0.0051 0.023 0.0703
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0256 0.0861
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.1139 0.3774
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0237 0.0237
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0045 0.015
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0039 0.016 0.0313
Echinococcus granulosus glutamate receptor 2 0.0018 0.0036 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0237 0.0465
Loa Loa (eye worm) hypothetical protein 0.0049 0.0215 0.0658
Trichomonas vaginalis glucosylceramidase, putative 0.0377 0.212 0.6427
Schistosoma mansoni zinc finger protein 0.0023 0.0062 0.0062
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Loa Loa (eye worm) hypothetical protein 0.0051 0.023 0.0703
Brugia malayi metabotropic glutamate receptor type 2 0.0093 0.0471 0.144
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0076 0.0233
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0037 0.0148 0.0453
Brugia malayi Pao retrotransposon peptidase family protein 0.0039 0.016 0.0489
Trichomonas vaginalis glucosylceramidase, putative 0.0397 0.2238 0.6794
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0039 0.016 0.016
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0256 0.062
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0156 0.0156
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0039 0.016 0.0319
Onchocerca volvulus 0.0051 0.023 0.0752
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0018 0.0036 0.007
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0232 0.0454
Echinococcus granulosus zinc finger protein 0.0023 0.0062 0.0206
Schistosoma mansoni protein kinase 0.0025 0.0076 0.0076

Activities

Activity type Activity value Assay description Source Reference
(functional) 0 Agonistic activity against Sphingosine 1-phosphate receptor ChEMBL. 16190743
Minimum single dose (functional) = 0.1 mg kg-1 Minimum single dose (p.o.) required for lowering of peripheral blood lymphocytes (PBLs) in dogs after 24 hrs of treatment; n=3 ChEMBL. 16190743
Minimum single dose (functional) = 0.2 mg kg-1 Minimum single dose (p.o.) required for lowering of peripheral blood lymphocytes (PBLs) in rats after 24 hrs of treatment; n=3 ChEMBL. 16190743
Minimum single dose (functional) = 1 mg kg-1 Minimum single dose (p.o.) required for lowering of peripheral blood lymphocytes (PBLs) in mice after 24 hrs of treatment; n=3 ChEMBL. 16190743
Resistance (functional) = 344 % Percent increase in airway resistance in anesthetized rats upon i.v. dose of 10 mpk over 30 min ChEMBL. 16190743
Survival (functional) = 13 day Median graft survival time upon p.o. dose of 1.0 mpk in combination with 1 mpk CsA per day for 28 days in rats by skin allograft experiment; n=14 ChEMBL. 16190743

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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