Detailed information for compound 350823

Basic information

Technical information
  • TDR Targets ID: 350823
  • Name: 4-amino-5-chloro-2-ethoxy-N-[[(1S,8S)-2,3,5,6 ,7,8-hexahydro-1H-pyrrolizin-1-yl]methyl]benz amide
  • MW: 337.844 | Formula: C17H24ClN3O2
  • H donors: 2 H acceptors: 1 LogP: 2.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(N)c(cc1C(=O)NC[C@@H]1CCN2[C@H]1CCC2)Cl
  • InChi: 1S/C17H24ClN3O2/c1-2-23-16-9-14(19)13(18)8-12(16)17(22)20-10-11-5-7-21-6-3-4-15(11)21/h8-9,11,15H,2-7,10,19H2,1H3,(H,20,22)/t11-,15-/m0/s1
  • InChiKey: QDTWANUYGDJQMC-NHYWBVRUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-azanyl-5-chloro-2-ethoxy-N-[[(1S,8S)-2,3,5,6,7,8-hexahydro-1H-pyrrolizin-1-yl]methyl]benzamide
  • 4-amino-5-chloro-2-ethoxy-N-[[(1S,8S)-pyrrolizidin-1-yl]methyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 3 (5-HT3) receptor Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Rattus norvegicus Serotonin 4 (5-HT4) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Get druggable targets OG5_133042 All targets in OG5_133042
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 489 aa 31.3 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.9 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Serotonin 4 (5-HT4) receptor   406 aa 390 aa 27.9 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Serotonin 3 (5-HT3) receptor   483 aa 490 aa 31.0 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 482 aa 23.9 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 477 aa 26.6 %
Echinococcus multilocularis nAChR subunit Serotonin 3 (5-HT3) receptor   483 aa 495 aa 24.2 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Serotonin 3 (5-HT3) receptor   483 aa 387 aa 25.6 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 27.7 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Serotonin 3 (5-HT3) receptor   483 aa 464 aa 24.8 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 505 aa 21.2 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Serotonin 3 (5-HT3) receptor   483 aa 478 aa 25.1 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 484 aa 26.0 %
Echinococcus multilocularis allatostatin A receptor Serotonin 4 (5-HT4) receptor   406 aa 331 aa 26.0 %
Onchocerca volvulus Large subunit GTPase 1 homolog Serotonin 3 (5-HT3) receptor   483 aa 394 aa 19.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 461 aa 24.3 %
Echinococcus granulosus allatostatin A receptor Serotonin 4 (5-HT4) receptor   406 aa 345 aa 25.2 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 336 aa 24.1 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 387 aa 30.5 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 452 aa 29.2 %
Brugia malayi Cation transporter family protein Serotonin 3 (5-HT3) receptor   483 aa 507 aa 28.2 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Serotonin 3 (5-HT3) receptor   483 aa 541 aa 25.5 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 386 aa 22.8 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Echinococcus granulosus orexin receptor type 2 Serotonin 4 (5-HT4) receptor   406 aa 445 aa 22.2 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.6 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 26.8 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 4 (5-HT4) receptor   406 aa 385 aa 31.7 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 346 aa 23.1 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.4 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 4 (5-HT4) receptor   406 aa 384 aa 33.3 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 4 (5-HT4) receptor   406 aa 445 aa 22.2 %
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   406 aa 352 aa 21.3 %
Onchocerca volvulus Putative zinc finger protein Serotonin 3 (5-HT3) receptor   483 aa 489 aa 25.8 %
Onchocerca volvulus Phospholipase d-related homolog Serotonin 4 (5-HT4) receptor   406 aa 389 aa 19.3 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   406 aa 351 aa 22.2 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Serotonin 3 (5-HT3) receptor   483 aa 514 aa 23.2 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 4 (5-HT4) receptor   406 aa 407 aa 25.1 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 482 aa 25.1 %
Loa Loa (eye worm) hypothetical protein Serotonin 4 (5-HT4) receptor   406 aa 384 aa 22.4 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 457 aa 24.7 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 463 aa 26.8 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 4 (5-HT4) receptor   406 aa 348 aa 30.7 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein Serotonin 3 (5-HT3) receptor   483 aa 388 aa 21.9 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Serotonin 3 (5-HT3) receptor   483 aa 503 aa 22.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 473 aa 27.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0199 0.1739 0.4115
Onchocerca volvulus 0.0205 0.1814 0.3652
Brugia malayi Pre-SET motif family protein 0.0062 0.0221 0.0252
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0205 0.1814 0.2124
Schistosoma mansoni opsin-like receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Echinococcus granulosus chromobox protein 1 0.0074 0.0363 0.0171
Echinococcus granulosus sex peptide receptor 0.0205 0.1814 0.1651
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0342 0.3333 0.437
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0035 0.0071
Onchocerca volvulus 0.0199 0.1739 0.3501
Echinococcus granulosus 7tm_1 domain containing protein 0.0205 0.1814 0.1651
Onchocerca volvulus 0.0205 0.1814 0.3652
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0205 0.1814 0.4301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Onchocerca volvulus 0.0144 0.113 0.2276
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi Cation transporter family protein 0.0342 0.3333 0.3798
Schistosoma mansoni nAChR subunit 0.0144 0.113 0.2608
Echinococcus multilocularis g protein coupled receptor 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0342 0.3333 0.4148
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus granulosus biogenic amine 5HT receptor 0.0205 0.1814 0.1651
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0342 0.3333 0.437
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.0826 0.0642
Brugia malayi Heterochromatin protein 1 0.0074 0.0363 0.0414
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0205 0.1814 0.4301
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Echinococcus granulosus glycine receptor subunit alpha 1 0.0342 0.3333 0.32
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0205 0.1814 0.2124
Schistosoma mansoni hypothetical protein 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0413 0.4116 0.5397
Echinococcus granulosus glycine receptor subunit alpha 1 0.0342 0.3333 0.32
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0199 0.1739 0.1982
Brugia malayi ORL1-like opioid receptor 0.0205 0.1814 0.2067
Echinococcus multilocularis sex peptide receptor 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0049 0.0077 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0205 0.1814 0.2124
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0205 0.1814 0.1651
Loa Loa (eye worm) hypothetical protein 0.0199 0.1739 0.2281
Loa Loa (eye worm) melatonin receptor type 1A 0.0205 0.1814 0.2379
Schistosoma mansoni biogenic amine receptor 0.0205 0.1814 0.4301
Schistosoma mansoni acetylcholine receptor-related 0.0144 0.113 0.2608
Brugia malayi Serotonin receptor 0.0697 0.7271 0.8287
Trypanosoma cruzi acyl-CoA oxidase, putative 0.01 0.0644 1
Brugia malayi hypothetical protein 0.0144 0.113 0.1288
Schistosoma mansoni amine GPCR 0.0205 0.1814 0.4301
Echinococcus multilocularis conserved hypothetical protein 0.0738 0.7723 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0205 0.1814 0.2067
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0144 0.113 0.1288
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0342 0.3333 0.3798
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Echinococcus multilocularis chromobox protein 1 0.0074 0.0363 0.0189
Schistosoma mansoni amine GPCR 0.0205 0.1814 0.4301
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0342 0.3333 0.8061
Schistosoma mansoni nAChR subunit 0.0342 0.3333 0.8061
Schistosoma mansoni biogenic amine (5HT) receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0342 0.3333 0.3798
Echinococcus granulosus tm gpcr rhodopsin 0.0205 0.1814 0.1651
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi G-protein coupled receptor 0.0205 0.1814 0.2067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Onchocerca volvulus 0.0205 0.1814 0.3652
Onchocerca volvulus 0.0074 0.0356 0.0717
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0413 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Onchocerca volvulus 0.0205 0.1814 0.3652
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0363 0.0731
Echinococcus multilocularis neuropeptide Y receptor 0.0205 0.1814 0.2124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0205 0.1814 0.2379
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0205 0.1814 0.4301
Echinococcus multilocularis orexin receptor type 2 0.0205 0.1814 0.2124
Echinococcus granulosus fmrfamide receptor 0.0205 0.1814 0.1651
Trypanosoma brucei acyl-CoA oxidase, putative 0.01 0.0644 1
Schistosoma mansoni chromobox protein 0.0074 0.0363 0.0708
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0342 0.3333 0.437
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Loa Loa (eye worm) G-protein coupled receptor 0.0205 0.1814 0.2379
Schistosoma mansoni opsin-like receptor 0.0205 0.1814 0.4301
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0205 0.1814 0.4301
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0342 0.3333 0.32
Echinococcus granulosus rhodopsin orphan GPCR 0.0205 0.1814 0.1651
Brugia malayi GnHR receptor homolog 0.0205 0.1814 0.2067
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0025 0.0032
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Mycobacterium ulcerans acyl-CoA dehydrogenase 0.0104 0.0686 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis neuropeptide receptor 0.0205 0.1814 0.2124
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0342 0.3333 0.3798
Plasmodium vivax SET domain protein, putative 0.0062 0.0221 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0205 0.1814 0.2067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Schistosoma mansoni neuropeptide f receptor 76f 0.0205 0.1814 0.4301
Schistosoma mansoni nAChR subunit 0.0342 0.3333 0.8061
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0205 0.1814 0.4301
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi Dopamine receptor 0.0205 0.1814 0.2067
Schistosoma mansoni neuropeptide F-like receptor 0.0205 0.1814 0.4301
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0035 0.0071
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0144 0.113 0.1288
Schistosoma mansoni lipoxygenase 0.0116 0.0826 0.1853
Loa Loa (eye worm) hypothetical protein 0.0062 0.0221 0.029
Onchocerca volvulus 0.0144 0.113 0.2276
Onchocerca volvulus 0.0342 0.3333 0.671
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0205 0.1814 0.2124
Brugia malayi putative neuropeptide receptor 0.0205 0.1814 0.2067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0221 0.0356
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0205 0.1814 0.2379
Echinococcus granulosus rhodopsin orphan GPCR 0.0205 0.1814 0.1651
Onchocerca volvulus 0.0413 0.4116 0.8286
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Schistosoma mansoni amine GPCR 0.0205 0.1814 0.4301
Brugia malayi Dopamine receptor protein 2 0.0205 0.1814 0.2067
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0205 0.1814 0.4301
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.0826 0.0806
Echinococcus multilocularis rhodopsin orphan GPCR 0.0205 0.1814 0.2124
Echinococcus multilocularis neuropeptide FF receptor 2 0.0205 0.1814 0.2124
Echinococcus granulosus dro:myosuppressin receptor 0.0205 0.1814 0.1651
Brugia malayi hypothetical protein 0.0144 0.113 0.1288
Loa Loa (eye worm) GABA receptor subunit 0.0199 0.1739 0.2281
Onchocerca volvulus 0.0205 0.1814 0.3652
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0199 0.1739 0.1982
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi Dopamine receptor protein 1 0.0205 0.1814 0.2067
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0199 0.1739 0.1982
Schistosoma mansoni acetylcholine receptor subunit beta 0.0144 0.113 0.2608
Schistosoma mansoni nAChR subunit 0.0144 0.113 0.2608
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0342 0.3333 0.4148
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0342 0.3333 0.3798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Schistosoma mansoni biogenic amine (5HT) receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0342 0.3333 0.8061
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0342 0.3333 0.32
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis chromobox protein 1 0.0074 0.0363 0.0189
Onchocerca volvulus 0.0144 0.113 0.2276
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Loa Loa (eye worm) hypothetical protein 0.0199 0.1739 0.2281
Onchocerca volvulus 0.0413 0.4116 0.8286
Loa Loa (eye worm) ACC-1 protein 0.0342 0.3333 0.437
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0205 0.1814 0.2124
Brugia malayi sulfakinin receptor protein 0.0205 0.1814 0.2067
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0205 0.1814 0.1651
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus granulosus allatostatin A receptor 0.0205 0.1814 0.1651
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0205 0.1814 0.4301
Mycobacterium leprae conserved hypothetical protein 0.01 0.0644 0.5
Onchocerca volvulus 0.0205 0.1814 0.3652
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Echinococcus multilocularis nAChR subunit 0.0199 0.1739 0.2024
Loa Loa (eye worm) ACC-1 protein 0.0342 0.3333 0.437
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Echinococcus granulosus g-protein coupled receptor 0.0205 0.1814 0.1651
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Schistosoma mansoni biogenic amine receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0729 0.7626 1
Schistosoma mansoni amine GPCR 0.0205 0.1814 0.4301
Echinococcus granulosus neuropeptide Y receptor 0.0205 0.1814 0.1651
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0342 0.3333 0.4148
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0144 0.113 0.1482
Loa Loa (eye worm) acetylcholine receptor protein 0.0144 0.113 0.1482
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0205 0.1814 0.2379
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0342 0.3333 0.437
Schistosoma mansoni lipoxygenase 0.0081 0.0438 0.0893
Schistosoma mansoni hypothetical protein 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0199 0.1739 0.2281
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0205 0.1814 0.4301
Echinococcus granulosus tm gpcr rhodopsin 0.0205 0.1814 0.1651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0205 0.1814 0.2124
Schistosoma mansoni histamine h1 receptor 0.0205 0.1814 0.4301
Echinococcus multilocularis G protein coupled receptor 139 0.0205 0.1814 0.2124
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0245 0.0321
Onchocerca volvulus 0.0199 0.1739 0.3501
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Onchocerca volvulus 0.0205 0.1814 0.3652
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Schistosoma mansoni nAChR subunit 0.0342 0.3333 0.8061
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0342 0.3333 0.3798
Schistosoma mansoni neurotransmitter gated ion channel 0.0144 0.113 0.2608
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0144 0.113 0.1482
Onchocerca volvulus 0.0205 0.1814 0.3652
Loa Loa (eye worm) hypothetical protein 0.0199 0.1739 0.2281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Echinococcus granulosus tumor protein p63 0.0333 0.323 0.3094
Schistosoma mansoni adenoreceptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0025 0.0032
Brugia malayi G-protein coupled receptor 0.0205 0.1814 0.2067
Echinococcus multilocularis fmrfamide receptor 0.0205 0.1814 0.2124
Echinococcus granulosus peptide allatostatin:somatostatin 0.0205 0.1814 0.1651
Echinococcus granulosus neuropeptide receptor 0.0205 0.1814 0.1651
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0342 0.3333 0.32
Echinococcus granulosus rhodopsin orphan GPCR 0.0205 0.1814 0.1651
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0144 0.113 0.1288
Brugia malayi Cation transporter family protein 0.0342 0.3333 0.3798
Echinococcus multilocularis glycine receptor subunit beta 0.0342 0.3333 0.4148
Schistosoma mansoni nAChR subunit 0.0342 0.3333 0.8061
Onchocerca volvulus 0.0205 0.1814 0.3652
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0342 0.3333 0.3798
Echinococcus granulosus neuropeptides capa receptor 0.0205 0.1814 0.1651
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Onchocerca volvulus 0.0342 0.3333 0.671
Onchocerca volvulus 0.0205 0.1814 0.3652
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0342 0.3333 0.3798
Schistosoma mansoni nAChR subunit 0.0342 0.3333 0.8061
Echinococcus multilocularis neuropeptide Y receptor 0.0205 0.1814 0.2124
Schistosoma mansoni nAChR subunit 0.0342 0.3333 0.8061
Schistosoma mansoni hypothetical protein 0.0205 0.1814 0.4301
Echinococcus granulosus glycine receptor subunit alpha 1 0.0342 0.3333 0.32
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0205 0.1814 0.4301
Echinococcus granulosus tachykinin peptides receptor 99D 0.0205 0.1814 0.1651
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0205 0.1814 0.2067
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0342 0.3333 0.4148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0221 0.0356
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0205 0.1814 0.2067
Echinococcus granulosus biogenic amine 5HT receptor 0.0205 0.1814 0.1651
Brugia malayi putative neuropeptide receptor NPR1 0.0205 0.1814 0.2067
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0342 0.3333 0.437
Echinococcus granulosus rhodopsin orphan GPCR 0.0205 0.1814 0.1651
Brugia malayi Serotonin receptor 0.0205 0.1814 0.2067
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0144 0.113 0.1212
Brugia malayi hypothetical protein 0.0144 0.113 0.1288
Echinococcus granulosus 7TM GPCR rhodopsin 0.0205 0.1814 0.1651
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0205 0.1814 0.2124
Echinococcus multilocularis serotonin receptor 0.0205 0.1814 0.2124
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0342 0.3333 0.3798
Echinococcus granulosus G protein coupled receptor 139 0.0205 0.1814 0.1651
Loa Loa (eye worm) CYP4Cod1 0.0044 0.0025 0.0032
Onchocerca volvulus Putative nachr subunit 0.0342 0.3333 0.671
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0205 0.1814 0.2124
Echinococcus granulosus chromobox protein 1 0.0074 0.0363 0.0171
Echinococcus multilocularis tumor protein p63 0.0333 0.323 0.4011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0342 0.3333 0.4148
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0035 0.0071
Echinococcus granulosus nAChR subunit 0.0342 0.3333 0.32
Loa Loa (eye worm) hypothetical protein 0.0413 0.4116 0.5397
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Onchocerca volvulus Neuropeptide F receptor homolog 0.0205 0.1814 0.3652
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0144 0.113 0.0953
Brugia malayi larval opioid receptor 0.0205 0.1814 0.2067
Brugia malayi follicle stimulating hormone receptor 0.0205 0.1814 0.2067
Schistosoma mansoni opsin-like receptor 0.0205 0.1814 0.4301
Onchocerca volvulus 0.0205 0.1814 0.3652
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0205 0.1814 0.4301
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0144 0.113 0.1212
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0205 0.1814 0.2067
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0342 0.3333 0.8061
Schistosoma mansoni neurotransmitter gated ion channel 0.0199 0.1739 0.4115
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0221 0.0026
Schistosoma mansoni amine GPCR 0.0205 0.1814 0.4301
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0205 0.1814 0.2124
Echinococcus multilocularis neuropeptides capa receptor 0.0205 0.1814 0.2124
Brugia malayi Melatonin receptor type 1A 0.0205 0.1814 0.2067
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi neuropeptide F receptor 0.0205 0.1814 0.2067
Echinococcus granulosus rhodopsin orphan GPCR 0.0205 0.1814 0.1651
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0363 0.0476
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Schistosoma mansoni neuropeptide receptor 0.0205 0.1814 0.4301
Schistosoma mansoni neuropeptide receptor 0.0205 0.1814 0.4301
Echinococcus granulosus neuropeptide FF receptor 2 0.0205 0.1814 0.1651
Echinococcus multilocularis G-protein coupled receptor, putative 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0199 0.1739 0.2281
Loa Loa (eye worm) neuropeptide F receptor 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis allatostatin A receptor 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus granulosus neuropeptides capa receptor 0.0205 0.1814 0.1651
Brugia malayi hypothetical protein 0.0144 0.113 0.1288
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Brugia malayi Cytochrome P450 family protein 0.0044 0.0025 0.0028
Loa Loa (eye worm) G-protein coupled receptor 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis rhodopsin orphan GPCR 0.0205 0.1814 0.2124
Toxoplasma gondii acyl-CoA dehydrogenase, middle domain-containing protein 0.0833 0.8775 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0205 0.1814 0.4301
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0144 0.113 0.1288
Echinococcus granulosus neuropeptide receptor 0.0205 0.1814 0.1651
Brugia malayi neuropeptide F receptor 0.0205 0.1814 0.2067
Brugia malayi Acyl-CoA oxidase family protein 0.0833 0.8775 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0342 0.3333 0.3798
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0342 0.3333 0.3798
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0144 0.113 0.1288
Echinococcus multilocularis g protein coupled receptor 0.0205 0.1814 0.2124
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0342 0.3333 0.3798
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0342 0.3333 0.32
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0144 0.113 0.1288
Onchocerca volvulus 0.0205 0.1814 0.3652
Schistosoma mansoni biogenic amine receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0342 0.3333 0.437
Echinococcus granulosus g protein coupled receptor 0.0205 0.1814 0.1651
Brugia malayi hypothetical protein 0.0144 0.113 0.1288
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi Cytochrome P450 family protein 0.0044 0.0025 0.0028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0342 0.3333 0.3798
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0205 0.1814 0.2124
Echinococcus granulosus orexin receptor type 2 0.0205 0.1814 0.1651
Echinococcus multilocularis neuropeptides capa receptor 0.0205 0.1814 0.2124
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0205 0.1814 0.2124
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0342 0.3333 0.4148
Echinococcus multilocularis neuropeptide receptor 0.0205 0.1814 0.2124
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0199 0.1739 0.2281
Echinococcus granulosus rhodopsin orphan GPCR 0.0205 0.1814 0.1651
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0199 0.1739 0.2281
Loa Loa (eye worm) hypothetical protein 0.01 0.0644 0.0844
Onchocerca volvulus 0.0342 0.3333 0.671
Onchocerca volvulus 0.0205 0.1814 0.3652
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0205 0.1814 0.1651
Schistosoma mansoni chromobox protein 0.0074 0.0363 0.0708
Loa Loa (eye worm) hypothetical protein 0.0269 0.2522 0.3307
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Echinococcus multilocularis fmrfamide receptor 0.0205 0.1814 0.2124
Echinococcus granulosus somatostatin receptor 0.0205 0.1814 0.1651
Brugia malayi Tachykinin-like peptides receptor 99D 0.0205 0.1814 0.2067
Echinococcus granulosus glycine receptor subunit beta 0.0342 0.3333 0.32
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0342 0.3333 0.3798
Onchocerca volvulus 0.0205 0.1814 0.3652
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0342 0.3333 0.4148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0221 0.0356
Schistosoma mansoni growth hormone secretagogue receptor 0.0205 0.1814 0.4301
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Onchocerca volvulus 0.0413 0.4116 0.8286
Leishmania major acyl-CoA oxidase, putative 0.01 0.0644 1
Brugia malayi Pre-SET motif family protein 0.043 0.4308 0.4909
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0144 0.113 0.0953
Echinococcus granulosus tm gpcr rhodopsin 0.0205 0.1814 0.1651
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Schistosoma mansoni neuropeptide F-like receptor 0.0205 0.1814 0.4301
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0342 0.3333 0.32
Onchocerca volvulus 0.0205 0.1814 0.3652
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0342 0.3333 0.4148
Echinococcus granulosus neuropeptide Y receptor 0.0205 0.1814 0.1651
Echinococcus granulosus neuropeptide receptor A26 0.0205 0.1814 0.1651
Echinococcus multilocularis g protein coupled receptor 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0342 0.3333 0.8061
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi hypothetical protein 0.01 0.0644 0.0733
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0342 0.3333 0.32
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0205 0.1814 0.1651
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Brugia malayi hypothetical protein 0.0205 0.1814 0.2067
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0205 0.1814 0.3652
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0413 0.4116 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus granulosus nAChR subunit 0.0199 0.1739 0.1574
Echinococcus multilocularis serotonin receptor 0.0205 0.1814 0.2124
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0342 0.3333 0.3798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0205 0.1814 0.4301
Brugia malayi G protein-coupled receptor 0.0205 0.1814 0.2067
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0205 0.1814 0.1651
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus granulosus serotonin receptor 0.0205 0.1814 0.1651
Onchocerca volvulus 0.0489 0.4967 1
Loa Loa (eye worm) neuropeptide F receptor 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0342 0.3333 0.4148
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.043 0.4308 0.5649
Echinococcus multilocularis dro:myosuppressin receptor 0.0205 0.1814 0.2124
Entamoeba histolytica hypothetical protein 0.0199 0.1739 0.5
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis rhodopsin orphan GPCR 0.0205 0.1814 0.2124
Schistosoma mansoni myosin xvIII 0.0205 0.1814 0.4301
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0205 0.1814 0.2124
Schistosoma mansoni hypothetical protein 0.0205 0.1814 0.4301
Echinococcus granulosus glycine receptor subunit beta 0.0342 0.3333 0.32
Echinococcus multilocularis g-protein coupled receptor 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus multilocularis neuropeptide s receptor 0.0205 0.1814 0.2124
Echinococcus multilocularis nAChR subunit 0.0342 0.3333 0.4148
Loa Loa (eye worm) hypothetical protein 0.0199 0.1739 0.2281
Loa Loa (eye worm) LGC-31 protein 0.0342 0.3333 0.437
Brugia malayi RE15519p 0.0205 0.1814 0.2067
Loa Loa (eye worm) TYRA-2 protein 0.0205 0.1814 0.2379
Echinococcus granulosus g protein coupled receptor 0.0205 0.1814 0.1651
Brugia malayi AKH receptor 0.0205 0.1814 0.2067
Trichomonas vaginalis set domain proteins, putative 0.0489 0.4967 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0205 0.1814 0.2124
Echinococcus granulosus g protein coupled receptor 0.0205 0.1814 0.1651
Schistosoma mansoni nAChR subunit 0.0342 0.3333 0.8061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0205 0.1814 0.2124
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Onchocerca volvulus 0.0205 0.1814 0.3652
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Schistosoma mansoni neuropeptide receptor 0.0205 0.1814 0.4301
Trypanosoma cruzi acyl-CoA oxidase, putative 0.01 0.0644 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Loa Loa (eye worm) hypothetical protein 0.0342 0.3333 0.437
Schistosoma mansoni neurotransmitter gated ion channel 0.0144 0.113 0.2608
Echinococcus granulosus neuropeptide s receptor 0.0205 0.1814 0.1651
Loa Loa (eye worm) acyl-CoA oxidase 0.0514 0.5234 0.6864
Echinococcus granulosus alpha 1A adrenergic receptor 0.0205 0.1814 0.1651
Onchocerca volvulus 0.0049 0.0077 0.0156
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0342 0.3333 0.3798
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0342 0.3333 0.3798
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0363 0.0731
Schistosoma mansoni neuropeptide receptor 0.0205 0.1814 0.4301
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0356 0.0691
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0205 0.1814 0.2379
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0342 0.3333 0.32
Brugia malayi Cation transporter family protein 0.0413 0.4116 0.469
Onchocerca volvulus 0.0205 0.1814 0.3652
Echinococcus multilocularis somatostatin receptor 0.0205 0.1814 0.2124
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0144 0.113 0.1212
Echinococcus multilocularis neuropeptide receptor A26 0.0205 0.1814 0.2124
Echinococcus granulosus rhodopsin orphan GPCR 0.0205 0.1814 0.1651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0205 0.1814 0.2124
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0199 0.1739 0.4115
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0205 0.1814 0.2067
Echinococcus multilocularis glycine receptor subunit beta 0.0342 0.3333 0.4148
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0205 0.1814 0.1651
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0199 0.1739 0.1982
Brugia malayi Cytochrome P450 family protein 0.0064 0.0245 0.0279
Loa Loa (eye worm) hypothetical protein 0.0205 0.1814 0.2379
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0342 0.3333 0.32
Loa Loa (eye worm) hypothetical protein 0.0144 0.113 0.1482
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0342 0.3333 0.4148
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0205 0.1814 0.2124
Brugia malayi excitatory GABA receptor EXP-1A 0.0342 0.3333 0.3798

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 195 nM Agonism at 5HT4 receptor in rat tunica muscularis mucosa ChEMBL. 16451077
EC50 (functional) = 195 nM Agonism at 5HT4 receptor in rat tunica muscularis mucosa ChEMBL. 16451077
IC50 (binding) = 5300 nM Binding affinity to dopamine receptor D2 ChEMBL. 16451077
IC50 (binding) = 5300 nM Binding affinity to dopamine receptor D2 ChEMBL. 16451077
Inhibition (functional) = 48 % Antagonism at 5HT3 receptor in mice by von Bezold-Jarisch reflex inhibition at 3 mg/kg, ip ChEMBL. 16451077
Inhibition (functional) = 48 % Antagonism at 5HT3 receptor in mice by von Bezold-Jarisch reflex inhibition at 3 mg/kg, ip ChEMBL. 16451077
Inhibition (functional) = 89 % Antagonism at 5HT3 receptor in mice by von Bezold-Jarisch reflex inhibition at 10 mg/kg, ip ChEMBL. 16451077
Inhibition (functional) = 89 % Antagonism at 5HT3 receptor in mice by von Bezold-Jarisch reflex inhibition at 10 mg/kg, ip ChEMBL. 16451077
Ki (binding) = 25 nM Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar rat ChEMBL. 16451077
Ki (binding) = 25 nM Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar rat ChEMBL. 16451077

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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