Detailed information for compound 36524

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.493 | Formula: C23H28N4O4
  • H donors: 2 H acceptors: 4 LogP: 2.88 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)[N+](=O)[O-])Nc1cc(CN2CCCC2)c(c(c1)CN1CCCC1)O
  • InChi: 1S/C23H28N4O4/c28-22-18(15-25-9-1-2-10-25)13-20(14-19(22)16-26-11-3-4-12-26)24-23(29)17-5-7-21(8-6-17)27(30)31/h5-8,13-14,28H,1-4,9-12,15-16H2,(H,24,29)
  • InChiKey: ZDJKPTSVPRZPBG-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus activin receptor type 0.0049 0.0096 0.0087
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.075
Brugia malayi hypothetical protein 0.006 0.0212 0.023
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.008 0.0433 0.193
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0127 0.0922 0.1
Giardia lamblia Kinase, AGC PKA 0.014 0.106 0.4708
Entamoeba histolytica p21-activated kinase 0.0076 0.0383 0.1658
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0142 0.1086 0.4845
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0141 0.1069 0.1287
Leishmania major casein kinase II, putative 0.0084 0.0472 0.2076
Loa Loa (eye worm) hypothetical protein 0.0077 0.0394 0.0428
Entamoeba histolytica cell division protein kinase 2, putative 0.0103 0.0667 0.2915
Echinococcus granulosus tyrosine protein kinase Fyn 0.0141 0.1069 0.1061
Schistosoma mansoni tyrosine kinase 0.0141 0.1069 0.1851
Giardia lamblia Kinase, PLK 0.0252 0.2241 1
Echinococcus multilocularis serine threonine protein kinase 0.0167 0.1347 0.1624
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0103 0.0667 0.2946
Trypanosoma cruzi polo-like protein kinase, putative 0.0252 0.2241 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0109 0.0731 0.3229
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0191 0.033
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0009 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0132 0.0979 0.4325
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0049 0.0096 0.043
Loa Loa (eye worm) TK/ROR protein kinase 0.0047 0.0079 0.0086
Schistosoma mansoni protein kinase 0.017 0.1375 0.238
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0168 0.0193
Trypanosoma brucei aurora B kinase 0.0129 0.0944 0.4144
Loa Loa (eye worm) hypothetical protein 0.0088 0.0511 0.0555
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0175 0.1435 0.1557
Echinococcus granulosus hypothetical protein 0.0062 0.0242 0.0233
Echinococcus multilocularis PAK box P21 Rho binding 0.0049 0.0101 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0745 0.3292
Giardia lamblia Aurora kinase 0.0129 0.0944 0.4189
Plasmodium falciparum NIMA related kinase 1 0.012 0.0847 0.7974
Echinococcus granulosus mitogen activated protein kinase 14 0.0142 0.1086 0.1077
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0472 0.2086
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.012 0.0847 0.7974
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.007 0.0326 0.0384
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0168 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Giardia lamblia Kinase, CMGC MAPK 0.0068 0.0302 0.1313
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Giardia lamblia Kinase, CMGC CDK 0.0103 0.0667 0.2946
Echinococcus granulosus dual specificity protein kinase clk2 0.008 0.0433 0.0425
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.022
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0057 0.0191 0.0851
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.012 0.0847 0.3811
Onchocerca volvulus 0.0114 0.0787 0.1463
Schistosoma mansoni tyrosine kinase 0.0382 0.3613 0.6255
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0074 0.0369 0.064
Echinococcus granulosus tyrosine protein kinase Srms 0.006 0.0212 0.0203
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Brugia malayi Protein kinase domain containing protein 0.017 0.1375 0.1491
Echinococcus multilocularis 0.0171 0.1388 0.1674
Schistosoma mansoni tyrosine kinase 0.0065 0.0269 0.0466
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.008 0.0433 0.1881
Entamoeba histolytica PH domain containing protein kinase, putative 0.0145 0.1117 0.4911
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0252 0.2241 0.2233
Echinococcus granulosus mitogen activated protein kinase 3 0.0068 0.0302 0.0293
Schistosoma mansoni serine/threonine-protein kinase 0.0145 0.1117 0.1933
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0168 0.0742
Echinococcus multilocularis mitogen activated protein kinase 14 0.0142 0.1086 0.1307
Schistosoma mansoni serine/threonine protein kinase 0.0374 0.3528 0.6108
Loa Loa (eye worm) SRC-1 0.0141 0.1069 0.116
Schistosoma mansoni tyrosine kinase 0.0586 0.5777 1
Brugia malayi Variant SH3 domain containing protein 0.0063 0.0246 0.0267
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0127 0.0922 0.0914
Schistosoma mansoni protein kinase 0.004 0.001 0.0017
Schistosoma mansoni hypothetical protein 0.006 0.0219 0.0379
Trichomonas vaginalis STE family protein kinase 0.007 0.0326 0.1439
Schistosoma mansoni tyrosine kinase 0.0061 0.0231 0.04
Plasmodium vivax casein kinase 1, putative 0.0055 0.0168 0.1511
Brugia malayi SH2 domain containing protein 0.006 0.0212 0.023
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Schistosoma mansoni serine/threonine kinase 0.0078 0.041 0.071
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0057 0.0191 0.1727
Brugia malayi casein kinase 1, delta 0.0055 0.0168 0.0182
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.017 0.1375 0.1491
Echinococcus multilocularis tyrosine protein kinase shark 0.006 0.0212 0.0246
Leishmania major casein kinase, putative 0.0055 0.0168 0.0711
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2265 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.0302 0.1349
Echinococcus multilocularis tyrosine protein kinase Abl 0.0161 0.1284 0.1547
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0084 0.0472 0.0512
Schistosoma mansoni tyrosine kinase 0.0083 0.046 0.0796
Echinococcus multilocularis cyclin dependent kinase 1 0.0103 0.0667 0.0798
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.004 0.001 0.0002
Giardia lamblia Kinase, NEK 0.012 0.0847 0.3754
Loa Loa (eye worm) hypothetical protein 0.0073 0.0351 0.0381
Loa Loa (eye worm) TK/ABL protein kinase 0.0264 0.2367 0.2568
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.004 0.001 0.0002
Schistosoma mansoni tyrosine kinase 0.0191 0.1598 0.2766
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0103 0.0667 0.0658
Echinococcus granulosus casein kinase I delta 0.0055 0.0168 0.0159
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0141 0.1069 0.1287
Echinococcus multilocularis hypothetical protein 0.006 0.0219 0.0254
Trichomonas vaginalis STE family protein kinase 0.0069 0.0312 0.1377
Echinococcus granulosus cyclin dependent kinase 5 0.0103 0.0667 0.0658
Trichomonas vaginalis STE family protein kinase 0.0049 0.0101 0.0444
Loa Loa (eye worm) hypothetical protein 0.0108 0.0729 0.0791
Echinococcus granulosus nervana 2 0.0122 0.0869 0.086
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0667 0.2944
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.014 0.106 1
Echinococcus multilocularis protein kinase shaggy 0.0112 0.0769 0.0922
Trichomonas vaginalis CAMK family protein kinase 0.0252 0.2241 0.9895
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0248 0.2207 0.2394
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2265 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0129 0.0944 0.4144
Brugia malayi Protein kinase c protein 2 0.0092 0.0555 0.0602
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0132 0.0978 0.1061
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.021 0.1796 0.1948
Brugia malayi Stress-activated protein kinase jnk-1 0.0246 0.2178 0.2362
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0068 0.0302 0.1349
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0302 0.1335
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0214 0.1846 0.1839
Echinococcus multilocularis growth factor receptor bound protein 2 0.0053 0.0138 0.0157
Echinococcus multilocularis mitogen activated protein kinase 0.0068 0.0302 0.0356
Loa Loa (eye worm) TK/EPH protein kinase 0.0111 0.0753 0.0817
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0472 0.2086
Trichomonas vaginalis CAMK family protein kinase 0.0252 0.2241 0.9895
Echinococcus multilocularis rho associated protein kinase 0.0306 0.2811 0.34
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0158 0.1253 0.1245
Schistosoma mansoni protein kinase 0.0202 0.1712 0.2964
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.041 0.071
Trichomonas vaginalis STE family protein kinase 0.007 0.0326 0.1439
Echinococcus multilocularis myosin iiia 0.0069 0.0312 0.0367
Echinococcus multilocularis dual specificity 0.0106 0.0702 0.0841
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.022
Entamoeba histolytica casein kinase 1, putative 0.0055 0.0168 0.0704
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.017 0.1381 0.1498
Echinococcus granulosus tyrosine protein kinase Lyn 0.0159 0.126 0.1252
Schistosoma mansoni growth factor receptor-bound protein 0.0053 0.0138 0.0239
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0055 0.0168 0.0182
Echinococcus granulosus tyrosine kinase 0.006 0.0212 0.0203
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.1022 0.1769
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0191 0.033
Echinococcus multilocularis tyrosine protein kinase Blk 0.0117 0.0821 0.0986
Echinococcus granulosus tyrosine protein kinase Fps85D 0.006 0.0212 0.0203
Schistosoma mansoni tyrosine kinase 0.0083 0.046 0.0796
Brugia malayi Protein kinase domain containing protein 0.0426 0.4087 0.4433
Schistosoma mansoni tyrosine kinase 0.0226 0.1965 0.3402
Loa Loa (eye worm) hypothetical protein 0.0137 0.1026 0.1112
Brugia malayi casein kinase I 0.0055 0.0168 0.0182
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0112 0.0769 0.3433
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.1703 0.2948
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0769 0.337
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0057 0.0191 0.0851
Echinococcus granulosus tyrosine protein kinase Src42A 0.0087 0.05 0.0491
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.0922 0.1597
Plasmodium vivax protein kinase Crk2 0.0103 0.0667 0.6259
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0183 0.1518 0.151
Entamoeba histolytica protein kinase, putative 0.0106 0.0702 0.3073
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0158 0.1253 0.151
Schistosoma mansoni vesicular amine transporter 0.0074 0.0369 0.064
Echinococcus granulosus raf serine:threonine protein kinase 0.0064 0.0261 0.0252
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2265 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0057 0.0191 0.0207
Schistosoma mansoni ste20-related kinase 0.0188 0.1564 0.2707
Brugia malayi serine/threonine-protein kinase PAK 7 0.0214 0.1844 0.2
Echinococcus granulosus tyrosine kinase 0.0117 0.0821 0.0813
Entamoeba histolytica protein kinase , putative 0.0129 0.0944 0.4144
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0103 0.0667 0.2991
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.2241 0.3879
Brugia malayi Protein kinase domain 0.007 0.0326 0.0354
Entamoeba histolytica SH2-protein kinase domain containing protein 0.006 0.0212 0.0899
Trypanosoma cruzi polo-like protein kinase, putative 0.0252 0.2241 1
Echinococcus granulosus Glutaredoxin protein 5 0.0122 0.0869 0.086
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.1022 0.1769
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0429 0.4112 0.4107
Schistosoma mansoni tyrosine kinase 0.0382 0.3613 0.6255
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0141 0.1069 0.1287
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0202 0.1712 0.1704
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.017 0.1375 0.1367
Plasmodium falciparum calcium-dependent protein kinase 1 0.004 0.001 0.0005
Trypanosoma brucei polo-like protein kinase 0.0252 0.2241 0.9894
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.004 0.001 0.0011
Brugia malayi map kinase activated protein kinase protein 2 0.0374 0.3528 0.3827
Plasmodium falciparum calcium-dependent protein kinase 2 0.004 0.001 0.0005
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0092 0.056 0.0551
Loa Loa (eye worm) hypothetical protein 0.0077 0.0394 0.0428
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0106 0.0702 0.3073
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.0302 0.1349
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0667 0.2944
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0944 0.4168
Echinococcus multilocularis 0.0062 0.0242 0.0283
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0063 0.0246 0.0426
Echinococcus granulosus tyrosine protein kinase Src42A 0.0141 0.1069 0.1061
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0238 0.2101 0.2279
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.0702 0.3073
Brugia malayi Sex muscle abnormal protein 5 0.0053 0.0138 0.015
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0055 0.0168 0.0182
Loa Loa (eye worm) hypothetical protein 0.0263 0.2364 0.2564
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0214 0.1846 0.223
Echinococcus granulosus mitogen activated protein kinase 11 0.0142 0.1086 0.1077
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0087 0.05 0.0595
Brugia malayi Protein kinase domain containing protein 0.0098 0.0618 0.067
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0066 0.0279 0.0327
Schistosoma mansoni vav2 0.0068 0.0303 0.0525
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0141 0.1069 0.1287
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0145 0.1117 0.4985
Plasmodium falciparum protein serine/threonine kinase-1 0.008 0.0433 0.4038
Brugia malayi ephrin receptor 1 precursor 0.006 0.0219 0.0237
Echinococcus granulosus dual specificity 0.0106 0.0702 0.0694
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0096 0.0386
Echinococcus multilocularis epidermal growth factor receptor 0.0586 0.5777 0.7001
Echinococcus multilocularis activin receptor type 0.0049 0.0096 0.0106
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0139 0.1055 0.1144
Trichomonas vaginalis CAMK family protein kinase 0.004 0.001 0.0043
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.021 0.1796 0.1789
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0069 0.0312 0.1342
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0069 0.0312 0.1392
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0382 0.3613 0.3607
Echinococcus granulosus N chimaerin 0.0063 0.0246 0.0237
Onchocerca volvulus 0.006 0.0212 0.0331
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Echinococcus multilocularis rac serine:threonine kinase 0.0145 0.1117 0.1344
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0301 0.2767 0.3001
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0129 0.0944 0.0936
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.075
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0112 0.0769 0.1332
Trichomonas vaginalis CAMK family protein kinase 0.0252 0.2241 0.9895
Schistosoma mansoni tyrosine kinase 0.006 0.0212 0.0367
Brugia malayi SRC-1 0.0141 0.1069 0.116
Loa Loa (eye worm) hypothetical protein 0.0109 0.0733 0.0795
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0162 0.1291 0.14
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0055 0.0163 0.0186
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0112 0.0769 0.3457
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0667 0.2944
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0057 0.0191 0.0851
Loa Loa (eye worm) hypothetical protein 0.0119 0.0844 0.0916
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0122 0.0869 0.086
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0142 0.1086 0.1177
Echinococcus granulosus mitogen activated protein kinase 0.0068 0.0302 0.0293
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0302 0.1335
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.1011 0.175
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0226 0.1965 0.2374
Trichomonas vaginalis CK1 family protein kinase 0.0055 0.0168 0.0742
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0601 0.5929 0.643
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0135 0.1011 0.1096
Brugia malayi Protein kinase domain containing protein 0.0169 0.1366 0.1482
Schistosoma mansoni protein kinase 0.007 0.0326 0.0564
Brugia malayi serine/threonine kinase 12 0.0129 0.0944 0.1024
Leishmania major protein kinase, putative 0.004 0.001 0.0002
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0183 0.1518 0.1647
Plasmodium falciparum calcium-dependent protein kinase 5 0.004 0.001 0.0005
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0112 0.0769 0.0834
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0084 0.0476 0.0516
Brugia malayi Protein kinase domain containing protein 0.0175 0.1435 0.1557
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0063 0.0246 0.0267
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0103 0.0667 0.2946
Loa Loa (eye worm) TK/EGFR protein kinase 0.0586 0.5777 0.6265
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0098 0.0618 0.067
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Loa Loa (eye worm) hypothetical protein 0.0117 0.082 0.0889
Onchocerca volvulus 0.006 0.0212 0.0331
Schistosoma mansoni protein kinase 0.0084 0.0472 0.0818
Schistosoma mansoni atypical protein kinase C 0.0248 0.2203 0.3813
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0214 0.1844 0.2
Echinococcus multilocularis nervana 2 0.0122 0.0869 0.1043
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.021 0.1796 0.2169
Schistosoma mansoni protein kinase 0.0202 0.1712 0.2964
Trichomonas vaginalis CAMK family protein kinase 0.0252 0.2241 0.9895
Plasmodium falciparum glycogen synthase kinase 3 0.0112 0.0769 0.7235
Loa Loa (eye worm) AUR protein kinase 0.0129 0.0944 0.1024
Brugia malayi Furin-like cysteine rich region family protein 0.0586 0.5777 0.6265
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0302 0.1335
Echinococcus multilocularis calcium activated potassium channel 0.0078 0.041 0.0486
Echinococcus granulosus protein kinase shaggy 0.0112 0.0769 0.0761
Echinococcus granulosus cyclin dependent kinase 0.0103 0.0667 0.0658
Echinococcus multilocularis cyclin dependent kinase 0.0103 0.0667 0.0798
Entamoeba histolytica protein kinase, putative 0.0129 0.0944 0.4144
Entamoeba histolytica protein kinase, putative 0.0248 0.2207 0.9747
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0101 0.0649 0.0704
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0057 0.0191 0.0207
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.075
Trypanosoma cruzi cdc2-related kinase 3 0.0103 0.0667 0.2975
Entamoeba histolytica serine/threonine protein kinase, putative 0.0252 0.2241 0.9894
Echinococcus multilocularis dual specificity protein kinase clk2 0.008 0.0433 0.0515
Echinococcus granulosus casein kinase I delta 0.0055 0.0168 0.0159
Giardia lamblia Kinase, CMGC GSK 0.0112 0.0769 0.3406
Echinococcus multilocularis serine:threonine protein kinase 0.0098 0.0618 0.0739
Loa Loa (eye worm) AUR protein kinase 0.0129 0.0944 0.1024
Loa Loa (eye worm) hypothetical protein 0.0109 0.0733 0.0795
Echinococcus multilocularis tyrosine protein kinase Srms 0.0117 0.0821 0.0986
Loa Loa (eye worm) hypothetical protein 0.0137 0.1026 0.1112
Brugia malayi P38 map kinase family protein 2 0.0142 0.1086 0.1177
Loa Loa (eye worm) hypothetical protein 0.0141 0.1075 0.1166
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.0922 0.1597
Onchocerca volvulus 0.0478 0.4631 0.9025
Echinococcus granulosus protein kinase c iota type 0.0242 0.2139 0.2132
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0175 0.1435 0.1557
Brugia malayi MAP kinase sur-1 0.0068 0.0302 0.0328
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0055 0.0168 0.0193
Onchocerca volvulus Serine\/threonine kinase homolog 0.0252 0.2241 0.4322
Brugia malayi intracellular kinase 0.0112 0.0769 0.0834
Echinococcus multilocularis mitogen activated protein kinase 3 0.0068 0.0302 0.0356
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0472 0.2086
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0057 0.0191 0.0804
Entamoeba histolytica protein kinase, putative 0.0112 0.0769 0.337
Echinococcus multilocularis raf serine:threonine protein kinase 0.0064 0.0261 0.0305
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.0182
Echinococcus granulosus serine:threonine protein kinase N2 0.0127 0.0922 0.0914
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0055 0.0168 0.075
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1435 0.2485
Onchocerca volvulus 0.006 0.0212 0.0331
Brugia malayi Casein kinase II, alpha chain 0.0084 0.0472 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0433 0.075
Loa Loa (eye worm) AGC/PKN protein kinase 0.0127 0.0922 0.1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Entamoeba histolytica PH domain containing protein kinase, putative 0.0063 0.0248 0.1058
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0055 0.0168 0.0159
Brugia malayi Fibronectin type III domain containing protein 0.0077 0.0394 0.0428
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0191 0.033
Echinococcus granulosus protein kinase c epsilon type 0.0162 0.1291 0.1283
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0057 0.0191 0.0804
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0226 0.1965 0.1958
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.0182
Echinococcus multilocularis ephrin type A receptor 4 A 0.0093 0.057 0.0681
Loa Loa (eye worm) TK protein kinase 0.0242 0.2139 0.232
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0055 0.0163 0.0153
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0084 0.0472 0.4409
Schistosoma mansoni protein kinase 0.0055 0.0163 0.0281
Trypanosoma cruzi Protein kinase B 0.0145 0.1117 0.4985
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0175 0.1435 0.2738
Echinococcus granulosus rho-associated protein kinase 1 0.0306 0.2811 0.2804
Giardia lamblia Kinase, CMGC CLK 0.008 0.0433 0.1901
Brugia malayi phosphoinositide-dependent protein kinase I 0.0066 0.0279 0.0302
Giardia lamblia Kinase, CMGC CDK 0.0103 0.0667 0.2946
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Brugia malayi Hr1 repeat family protein 0.0127 0.0922 0.1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0049 0.0096 0.0386
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.004 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0075 0.0372 0.0403
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0053 0.0138 0.0239
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0055 0.0168 0.0193
Plasmodium falciparum serine/threonine protein kinase, putative 0.0129 0.0944 0.8898
Onchocerca volvulus 0.006 0.0212 0.0331
Brugia malayi protein kinase C II. 0.0162 0.1291 0.14
Schistosoma mansoni protein kinase 0.0049 0.0101 0.0174
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0168 0.0193
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0158 0.1253 0.151
Trichomonas vaginalis AGC family protein kinase 0.012 0.0847 0.374
Trypanosoma brucei Casein kinase II 0.0084 0.0472 0.2054
Trypanosoma brucei protein kinase, putative 0.0112 0.0769 0.337
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0068 0.0302 0.1313
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.1703 0.2948
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2265 1
Trichomonas vaginalis STE family protein kinase 0.007 0.0326 0.1439
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0279 0.1231
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.014 0.106 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0112 0.0769 0.0761
Loa Loa (eye worm) hypothetical protein 0.0137 0.1026 0.1112
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0127 0.0922 0.1108
Echinococcus granulosus nervana 2 0.0122 0.0869 0.086
Echinococcus multilocularis serine:threonine protein kinase N2 0.0127 0.0922 0.1108
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.004 0.001 0.0005
Echinococcus multilocularis casein kinase I alpha 0.0055 0.0168 0.0193
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0141 0.1069 0.1287
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.041 0.071
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0922 0.4073
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0135 0.1011 0.1003
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2265 1
Echinococcus granulosus roundabout 2 0.0111 0.0758 0.075
Schistosoma mansoni serine/threonine protein kinase 0.004 0.001 0.0017
Echinococcus multilocularis Immunoglobulin 0.0074 0.0369 0.0437
Schistosoma mansoni nephrin 0.0093 0.0568 0.0984
Loa Loa (eye worm) hypothetical protein 0.0074 0.0369 0.0401
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.022
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0618 0.2729
Trypanosoma cruzi cdc2-related kinase 1 0.0103 0.0667 0.2975
Trypanosoma cruzi aurora B kinase, putative 0.0129 0.0944 0.4213
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0055 0.0168 0.0159
Loa Loa (eye worm) AGC/PKA protein kinase 0.0057 0.0191 0.0207
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0394 0.0428
Entamoeba histolytica protein kinase, putative 0.0054 0.0158 0.0658
Loa Loa (eye worm) hypothetical protein 0.0088 0.0511 0.0555
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.001
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0944 0.4168
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0279 0.1231
Echinococcus granulosus calcium activated potassium channel 0.0078 0.041 0.0401
Loa Loa (eye worm) AGC/NDR protein kinase 0.0127 0.0922 0.1
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Leishmania major protein kinase, putative 0.0049 0.0096 0.039
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.004 0.0009 0.001
Brugia malayi Kinase associated domain 1 family protein 0.006 0.0219 0.0237
Entamoeba histolytica casein kinase, putative 0.0055 0.0168 0.0704
Leishmania major protein kinase, putative 0.008 0.0433 0.1901
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.014 0.106 0.1275
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0047 0.0079 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0078 0.041 0.181
Echinococcus granulosus tyrosine protein kinase Fyn 0.0141 0.1069 0.1061
Echinococcus multilocularis cyclin dependent kinase 5 0.0103 0.0667 0.0798
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.0922 0.1597
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0078 0.041 0.0445
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.0915 0.0992
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0068 0.0302 0.1349
Loa Loa (eye worm) hypothetical protein 0.0053 0.0138 0.015
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0472 0.2086
Onchocerca volvulus 0.0119 0.0844 0.1575
Brugia malayi hypothetical protein 0.0077 0.0394 0.0428
Brugia malayi SH2 domain containing protein 0.006 0.0212 0.023
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.2811 0.4866
Loa Loa (eye worm) hypothetical protein 0.0098 0.0618 0.067
Entamoeba histolytica cell division protein kinase 2, putative 0.0103 0.0667 0.2915
Echinococcus granulosus defective proboscis extension response 0.0074 0.0369 0.0361
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0057 0.0191 0.0804
Trypanosoma brucei protein kinase, putative 0.0068 0.0302 0.1299
Loa Loa (eye worm) hypothetical protein 0.0077 0.0394 0.0428
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.004 0.001 0.0005
Echinococcus granulosus casein kinase I alpha 0.0055 0.0168 0.0159
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0068 0.0302 0.1313
Plasmodium vivax unspecified product 0.0084 0.0472 0.4409
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0183 0.1518 0.1831
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.004 0.001 0.0002
Plasmodium vivax calcium-dependent protein kinase, putative 0.004 0.001 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0053 0.0138 0.015
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0055 0.0168 0.0182
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0074 0.0369 0.064
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0702 0.1216
Toxoplasma gondii AGC kinase 0.0057 0.0191 0.0825
Giardia lamblia Kinase, AGC PKA 0.0057 0.0191 0.0813
Schistosoma mansoni nck2/grb4 0.0053 0.0138 0.0239
Brugia malayi Protein kinase domain containing protein 0.0066 0.0279 0.0302
Brugia malayi putative serine/threonine kinase SADA gamma 0.004 0.0009 0.001
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0987 0.1708
Giardia lamblia Kinase, STE STE20 0.0069 0.0312 0.1356
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0135 0.0595
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1291 0.2235
Giardia lamblia Kinase, STE STE20 0.007 0.0326 0.1419
Trypanosoma cruzi cdc2-related kinase 1 0.0103 0.0667 0.2975
Brugia malayi Cam kinase protein 1 0.004 0.001 0.0011
Brugia malayi Protein kinase domain containing protein 0.0913 0.922 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0122 0.0869 0.1043
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0127 0.0922 0.0914
Entamoeba histolytica protein kinase, putative 0.0127 0.0922 0.4049
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.008 0.0433 0.1935
Echinococcus multilocularis tyrosine protein kinase HCK 0.0088 0.0515 0.0613
Echinococcus granulosus growth factor receptor bound protein 2 0.0053 0.0138 0.0129
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0175 0.1435 0.1731
Loa Loa (eye worm) hypothetical protein 0.0074 0.0369 0.0401
Echinococcus granulosus tyrosine protein kinase Fyn 0.0141 0.1069 0.1061
Echinococcus granulosus neuroglian 0.0091 0.0543 0.0534
Brugia malayi Temporarily assigned gene name protein 59 0.0127 0.0924 0.1002
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0129 0.0944 0.4144
Onchocerca volvulus Tyrosine kinase homolog 0.0525 0.5126 1
Entamoeba histolytica protein kinase, putative 0.0047 0.0081 0.032
Echinococcus granulosus casein kinase ii subunit alpha 0.0084 0.0472 0.0464
Loa Loa (eye worm) hypothetical protein 0.006 0.0219 0.0237
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0135 0.1011 0.1096
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0264 0.2367 0.2862
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0141 0.1069 0.1287
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0129 0.0944 0.4144
Brugia malayi cell division control protein 2 homolog 0.0103 0.0667 0.0723
Trichomonas vaginalis STE family protein kinase 0.012 0.0847 0.374
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0302 0.0523
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0066 0.0279 0.0302
Brugia malayi Protein kinase domain containing protein 0.0106 0.0702 0.0762
Entamoeba histolytica protein kinase, putative 0.0254 0.2265 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0141 0.1069 0.1287
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.007 0.0326 0.0384
Brugia malayi Protein kinase domain containing protein 0.006 0.0212 0.023
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.007 0.0326 0.0317
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0141 0.1069 0.1287
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0142 0.1086 0.4824
Echinococcus granulosus serine/threonine protein kinase 0.0145 0.1117 0.1109
Brugia malayi Protein kinase domain containing protein 0.0183 0.1518 0.1647
Brugia malayi Protein kinase domain containing protein 0.0078 0.041 0.0445
Giardia lamblia Kinase, CMGC CK2 0.0084 0.0472 0.2076
Schistosoma mansoni serine/threonine protein kinase 0.021 0.1796 0.311
Schistosoma mansoni tyrosine kinase 0.0426 0.4087 0.7076
Schistosoma mansoni protein kinase 0.004 0.001 0.0017
Echinococcus granulosus tyrosine protein kinase ABL1 0.0264 0.2367 0.236
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.008 0.0433 0.1935
Loa Loa (eye worm) hypothetical protein 0.0092 0.056 0.0607
Echinococcus granulosus serine:threonine protein kinase 0.0098 0.0618 0.0609
Brugia malayi Variant SH3 domain containing protein 0.0053 0.0138 0.015
Echinococcus granulosus epidermal growth factor receptor 0.0586 0.5777 0.5773
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0158 0.1253 0.1245
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0055 0.0164 0.0177
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0922 0.4073
Trypanosoma cruzi casein kinase II, putative 0.0084 0.0472 0.2109
Brugia malayi Variant SH3 domain containing protein 0.0053 0.0138 0.015
Schistosoma mansoni kinase 0.027 0.2432 0.4211
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0066 0.0279 0.027
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0202 0.1712 0.2067
Echinococcus multilocularis death associated protein kinase 1 0.082 0.8248 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.004 0.001 0.0005
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0128 0.0937 0.1126
Entamoeba histolytica protein kinase domain containing protein 0.0084 0.0472 0.2054
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0472 0.2086
Loa Loa (eye worm) hypothetical protein 0.0057 0.0191 0.0207
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0057 0.0191 0.0851
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.1518 0.2628
Toxoplasma gondii casein kinase I 0.0055 0.0168 0.0722
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0175 0.1435 0.1427
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.007 0.0326 0.0317
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0922 0.4073
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Echinococcus multilocularis serine:threonine protein kinase 3 0.0238 0.2101 0.2539
Leishmania major protein kinase A catalytic subunit isoform 1 0.0057 0.0191 0.0813
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Brugia malayi Immunoglobulin I-set domain containing protein 0.0601 0.5929 0.643
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0226 0.1965 0.2374
Echinococcus multilocularis NCK adaptor protein 0.0053 0.0138 0.0157
Brugia malayi Protein kinase domain containing protein 0.006 0.0212 0.023
Giardia lamblia Kinase, CMGC GSK 0.0112 0.0769 0.3406
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0069 0.0312 0.1342
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0141 0.1069 0.1061
Echinococcus granulosus NCK adaptor protein 0.0053 0.0138 0.0129
Schistosoma mansoni serine/threonine kinase 0.0127 0.0922 0.1597
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.008 0.0433 0.1935
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0009 0.0016
Loa Loa (eye worm) TK protein kinase 0.0088 0.0515 0.0558
Loa Loa (eye worm) hypothetical protein 0.004 0.001 0.0011
Plasmodium falciparum protein kinase, putative 0.0049 0.0096 0.0829
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0191 0.0842
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Leishmania major protein kinase, putative 0.0129 0.0944 0.4189
Trypanosoma brucei rac serine-threonine kinase, putative 0.0254 0.2265 1
Echinococcus granulosus aurora kinase A 0.0129 0.0944 0.0936
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0074 0.0369 0.0437
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0141 0.1069 0.1287
Brugia malayi Protein kinase domain containing protein 0.0172 0.1397 0.1515
Entamoeba histolytica protein kinase, putative 0.0049 0.0101 0.0405
Leishmania major protein kinase, putative 0.008 0.0433 0.1901
Schistosoma mansoni protein kinase 0.0055 0.0168 0.0291
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.007 0.0326 0.0384
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0063 0.0246 0.0237
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0745 0.3292
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0063 0.0246 0.0426
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0374 0.3528 0.4272
Entamoeba histolytica hypothetical protein 0.0106 0.0702 0.3073
Onchocerca volvulus 0.0112 0.0769 0.1427
Brugia malayi Protein kinase domain containing protein 0.006 0.0212 0.023
Schistosoma mansoni ephrin receptor 0.0093 0.057 0.0988
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0009 0.0041
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0106 0.0702 0.3135
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.022
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0063 0.0246 0.0287
Schistosoma mansoni growth factor receptor-bound protein 0.0053 0.0138 0.0239
Echinococcus granulosus Immunoglobulin 0.0074 0.0369 0.0361
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0069 0.0312 0.1342
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0103 0.0667 0.0723
Brugia malayi p70 ribosomal S6 kinase beta 0.0248 0.2207 0.2394
Echinococcus multilocularis mitogen activated protein kinase 11 0.0142 0.1086 0.1307
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0112 0.0769 0.0834
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0129 0.0944 0.8898
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0103 0.0667 0.0723
Trypanosoma brucei casein kinase I, isoform 2 0.0055 0.0168 0.0704
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0066 0.0279 0.0302
Onchocerca volvulus 0.0063 0.0249 0.0403
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0141 0.1069 0.1061
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0117 0.0821 0.0813
Schistosoma mansoni serine/threonine protein kinase 0.0246 0.2178 0.3771
Echinococcus multilocularis protein kinase c iota type 0.0242 0.2139 0.2586
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0049 0.0096 0.043
Echinococcus granulosus tyrosine protein kinase shark 0.006 0.0212 0.0203
Echinococcus multilocularis neuroglian 0.0091 0.0543 0.0648
Entamoeba histolytica protein kinase, putative 0.004 0.001 0.0002
Onchocerca volvulus 0.0287 0.262 0.5068
Loa Loa (eye worm) hypothetical protein 0.0063 0.0249 0.027
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0057 0.0191 0.0182
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0103 0.0667 0.0723
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0429 0.4112 0.498
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.008 0.0432 0.0468
Echinococcus multilocularis protein kinase c epsilon type 0.0162 0.1291 0.1556
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0769 0.3397
Echinococcus multilocularis cyclin dependent kinase 1 0.0103 0.0667 0.0798
Entamoeba histolytica protein kinase, putative 0.0066 0.0279 0.1195
Plasmodium vivax serine/threonine kinase-1, putative 0.008 0.0433 0.4038
Loa Loa (eye worm) hypothetical protein 0.008 0.0432 0.0468
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0106 0.0702 0.0762
Entamoeba histolytica protein kinase, putative 0.0055 0.0168 0.0705
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0068 0.0302 0.0328
Leishmania major protein kinase A catalytic subunit 0.0057 0.0191 0.0813
Schistosoma mansoni adapter molecule crk 0.0053 0.0138 0.0239
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.004 0.001 0.0005
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0057 0.0191 0.1727
Echinococcus granulosus epidermal growth factor receptor 0.0382 0.3613 0.3607
Loa Loa (eye worm) hypothetical protein 0.0062 0.0242 0.0263
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.1253 0.2169
Echinococcus granulosus ephrin type A receptor 4 A 0.0093 0.057 0.0562
Onchocerca volvulus 0.0137 0.1026 0.1932
Plasmodium falciparum casein kinase 1 0.0055 0.0168 0.1511
Echinococcus granulosus serine:threonine protein kinase 0.0098 0.0618 0.0609
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0261 0.0452
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0112 0.0769 0.0922
Entamoeba histolytica protein kinase, putative 0.007 0.0326 0.1404
Giardia lamblia Kinase, AGC AKT 0.0101 0.0649 0.2866
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0944 0.4168
Toxoplasma gondii AGC kinase 0.0248 0.2207 1
Schistosoma mansoni protein kinase 0.004 0.001 0.0017
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0106 0.0702 0.3106
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0472 0.2086
Echinococcus granulosus NDR protein kinase 0.0127 0.0922 0.0914
Brugia malayi STE20-like kinase MST 0.0238 0.2101 0.2279
Entamoeba histolytica protein kinase, putative 0.0042 0.0023 0.0061
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0068 0.0302 0.1333
Entamoeba histolytica protein kinase, putative 0.0054 0.0158 0.0658
Loa Loa (eye worm) CMGC/CLK protein kinase 0.008 0.0433 0.047
Echinococcus multilocularis serine:threonine protein kinase 38 0.0127 0.0922 0.1108
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.075
Echinococcus granulosus serine:threonine protein kinase 3 0.0238 0.2101 0.2094
Schistosoma mansoni hypothetical protein 0.006 0.0219 0.0379
Echinococcus multilocularis casein kinase i 0.0055 0.0168 0.0193
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0374 0.3528 0.3827
Schistosoma mansoni cell adhesion molecule 0.0095 0.0585 0.1012
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.004 0.0009 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0944 0.1634
Trypanosoma cruzi cdc2-related kinase 3 0.0103 0.0667 0.2975
Echinococcus granulosus c-Jun N-terminal kinases 0.0246 0.2178 0.2171
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0127 0.0922 0.1108
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0944 0.4168
Brugia malayi protein kinase C3,putative 0.0133 0.0992 0.1076
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0252 0.2241 0.2709
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0168 0.0291
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.004 0.001 0.0011
Echinococcus multilocularis mitogen activated protein kinase 11 0.0142 0.1086 0.1307
Echinococcus multilocularis serine:threonine protein kinase N2 0.0127 0.0922 0.1108
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0769 0.3397
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0252 0.2241 0.243
Brugia malayi Protein kinase domain containing protein 0.0127 0.0922 0.1
Brugia malayi protein-tyrosine kinase 0.0117 0.0821 0.0891
Echinococcus multilocularis epidermal growth factor receptor 0.0382 0.3613 0.4375
Loa Loa (eye worm) TK protein kinase 0.0117 0.0821 0.0891
Loa Loa (eye worm) AUR protein kinase 0.0129 0.0944 0.1024
Brugia malayi RhoGAP domain containing protein 0.0063 0.0246 0.0267
Echinococcus multilocularis casein kinase I delta 0.0055 0.0168 0.0193
Schistosoma mansoni tyrosine kinase 0.0141 0.1069 0.1851
Echinococcus granulosus tyrosine protein kinase HCK 0.0088 0.0515 0.0506
Echinococcus granulosus fibroblast growth factor receptor 4 0.0226 0.1965 0.1958
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2265 1
Schistosoma mansoni serine/threonine-protein kinase 0.0145 0.1117 0.1933
Echinococcus multilocularis casein kinase I delta 0.0055 0.0168 0.0193
Echinococcus granulosus twitchin 0.0109 0.0734 0.0726
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0136 0.1022 0.1229
Loa Loa (eye worm) TK/INSR protein kinase 0.0426 0.4087 0.4433
Entamoeba histolytica protein kinase, putative 0.0254 0.2265 1
Echinococcus multilocularis c src tyrosine kinase 0.0083 0.046 0.0547
Echinococcus multilocularis Glutaredoxin protein 5 0.0122 0.0869 0.1043
Schistosoma mansoni tyrosine kinase 0.0235 0.206 0.3567
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.004 0.001 0.0001
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0049 0.0096 0.0396
Echinococcus granulosus Protein kinase C brain isozyme 0.0201 0.1703 0.1695
Brugia malayi Protein kinase domain containing protein 0.0254 0.2265 0.2456
Leishmania major protein kinase A catalytic subunit isoform 2 0.0057 0.0191 0.0813
Loa Loa (eye worm) hypothetical protein 0.0114 0.0787 0.0854
Brugia malayi Immunoglobulin I-set domain containing protein 0.0242 0.2139 0.232
Plasmodium falciparum casein kinase 2, alpha subunit 0.0084 0.0472 0.4409
Giardia lamblia Kinase, NEK 0.012 0.0847 0.3754
Echinococcus multilocularis aurora kinase A 0.0129 0.0944 0.1135
Echinococcus granulosus tyrosine protein kinase Src64B 0.0141 0.1069 0.1061
Brugia malayi Protein kinase domain containing protein 0.006 0.0212 0.023
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0168 0.0291
Entamoeba histolytica protein kinase domain containing protein 0.0129 0.0944 0.4144
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0106 0.0702 0.3135
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.1253 0.2169
Schistosoma mansoni protein kinase 0.007 0.0326 0.0564
Echinococcus multilocularis Immunoglobulin 0.0074 0.0369 0.0437
Plasmodium falciparum calcium-dependent protein kinase 4 0.004 0.001 0.0005
Schistosoma mansoni tyrosine kinase 0.0426 0.4087 0.7076
Echinococcus granulosus cyclin dependent kinase 1 0.0103 0.0667 0.0658
Trichomonas vaginalis STE family protein kinase 0.007 0.0326 0.1439
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0769 0.337
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0252 0.2241 1
Brugia malayi Protein kinase domain containing protein 0.0103 0.0667 0.0723
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0433 0.075
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0098 0.0623 0.0675
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0129 0.0944 0.1135
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0117 0.0821 0.0986
Giardia lamblia Kinase, CK1 Casein kinase 0.0055 0.0168 0.0711
Schistosoma mansoni tyrosine kinase 0.0351 0.3292 0.5698
Onchocerca volvulus 0.0306 0.2811 0.5444
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.041 0.071
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.017 0.1375 0.1657
Brugia malayi Protein kinase domain containing protein 0.008 0.0433 0.047
Echinococcus granulosus casein kinase I alpha 0.0055 0.0168 0.0159
Brugia malayi C1-like domain containing protein 0.0132 0.0978 0.1061
Echinococcus multilocularis casein kinase ii subunit alpha 0.0084 0.0472 0.0562
Schistosoma mansoni protein kinase C mu 0.0132 0.0978 0.1694
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.006 0.0212 0.0246
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0472 0.2086
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.004 0.001 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0302 0.1335
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0252 0.2241 0.9895
Brugia malayi serine/threonine-protein kinase 6 0.0129 0.0944 0.1024
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0279 0.1231
Entamoeba histolytica protein kinase, putative 0.0055 0.0168 0.0705
Echinococcus granulosus protein kinase C gamma type 0.0167 0.1347 0.1339
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0106 0.0706 0.3122
Leishmania major protein kinase, putative 0.0069 0.0312 0.1356
Echinococcus multilocularis nervana 2 0.0122 0.0869 0.1043
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.008 0.0433 0.1935
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0053 0.0138 0.015
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0083 0.046 0.0796
Brugia malayi serine/threonine protein kinase 6 0.0129 0.0944 0.1024
Echinococcus granulosus casein kinase i 0.0055 0.0168 0.0159
Echinococcus multilocularis N chimaerin 0.0063 0.0246 0.0287
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0068 0.0302 0.1299
Entamoeba histolytica protein kinase 2, putative 0.014 0.106 0.4658
Trypanosoma cruzi rac serine-threonine kinase, putative 0.014 0.106 0.4729
Entamoeba histolytica protein kinase, putative 0.0106 0.0702 0.3073
Entamoeba histolytica PH domain containing protein kinase, putative 0.0145 0.1117 0.4911
Echinococcus granulosus tyrosine protein kinase Blk 0.0117 0.0821 0.0813
Giardia lamblia Kinase, NEK 0.012 0.0847 0.3754
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.001 0.0001
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0128 0.0937 0.0929
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0374 0.3528 0.3522
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0246 0.2178 0.2633
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.014 0.106 0.1051
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0069 0.0312 0.1392
Echinococcus multilocularis mitogen activated protein kinase 14 0.0142 0.1086 0.1307
Schistosoma mansoni protein kinase 0.0129 0.0944 0.1634
Trichomonas vaginalis AGC family protein kinase 0.0254 0.2265 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0112 0.0769 0.3406
Onchocerca volvulus 0.006 0.0212 0.0331
Echinococcus granulosus casein kinase I alpha 0.0055 0.0168 0.0159
Entamoeba histolytica protein kinase, putative 0.0088 0.0515 0.2241
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0212 0.023
Schistosoma mansoni tyrosine kinase 0.0351 0.3292 0.5698
Schistosoma mansoni protein kinase 0.0049 0.0096 0.0167
Brugia malayi Tyrosine-protein kinase abl-1 0.0161 0.1284 0.1393
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0142 0.1086 0.4773
Echinococcus multilocularis serine:threonine protein kinase 0.0098 0.0618 0.0739
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0047 0.0079 0.007
Brugia malayi Protein kinase domain containing protein 0.006 0.0212 0.023
Echinococcus granulosus c src tyrosine kinase 0.0083 0.046 0.0451
Onchocerca volvulus 0.0055 0.0168 0.0244
Echinococcus multilocularis tyrosine kinase 0.006 0.0212 0.0246
Loa Loa (eye worm) AGC/AKT protein kinase 0.0254 0.2265 0.2456
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0667 0.1154
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0667 0.1154
Trypanosoma brucei cdc2-related kinase 1 0.0103 0.0667 0.2915
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0246 0.2178 0.2362
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0136 0.1022 0.1014
Trypanosoma cruzi casein kinase, putative 0.0055 0.0168 0.075
Trichomonas vaginalis CAMK family protein kinase 0.0252 0.2241 0.9895
Plasmodium vivax glycogen synthase kinase 3, putative 0.0112 0.0769 0.7235
Toxoplasma gondii aurora kinase 0.0129 0.0944 0.4252
Entamoeba histolytica PH domain containing protein kinase, putative 0.0063 0.0248 0.1058
Echinococcus multilocularis insulin receptor 0.0426 0.4087 0.495
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0047 0.0081 0.032
Onchocerca volvulus 0.008 0.0432 0.0763
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0142 0.1086 0.4845
Trypanosoma brucei protein kinase, putative 0.0049 0.0096 0.0386
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0175 0.1435 0.1557
Entamoeba histolytica casein kinase, putative 0.0084 0.0472 0.2054
Echinococcus granulosus insulin receptor 0.0426 0.4087 0.4082
Echinococcus granulosus serine threonine protein kinase nrc 0.014 0.106 0.1051
Trypanosoma brucei cdc2-related kinase 3 0.0103 0.0667 0.2915
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0058 0.02 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0479 0.083
Echinococcus multilocularis roundabout 2 0.0111 0.0758 0.0909
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0433 0.1914
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0279 0.0483
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0201 0.1703 0.2056
Brugia malayi probable protein kinase 0.0055 0.0163 0.0176
Brugia malayi serine/threonine-protein kinase plk-2 0.0252 0.2241 0.243
Trichomonas vaginalis CAMK family protein kinase 0.0252 0.2241 0.9895
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0135 0.1011 0.1216
Plasmodium falciparum protein kinase 5 0.0103 0.0667 0.6259
Entamoeba histolytica protein kinase, putative 0.0129 0.0944 0.4144
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.008 0.0433 0.1881
Toxoplasma gondii CMGC kinase, CK2 family 0.0084 0.0472 0.2107
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0132 0.0978 0.1061
Schistosoma mansoni tyrosine kinase 0.0351 0.3292 0.5698
Brugia malayi Protein kinase domain containing protein 0.0127 0.0922 0.1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0057 0.0191 0.0825
Toxoplasma gondii AGC kinase 0.0057 0.0191 0.0825
Onchocerca volvulus 0.006 0.0212 0.0331
Loa Loa (eye worm) hypothetical protein 0.006 0.0212 0.023
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0913 0.922 1
Trypanosoma cruzi SNF1-related protein kinases, putative 0.004 0.0009 0.0041
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.007 0.0326 0.0317

Activities

Activity type Activity value Assay description Source Reference
Dose (functional) = 11 mg kg-1 Evaluated for ouabain-induced arrhythmia in anesthetized adult male mongrel dogs. Administered intravenously. ChEMBL. 6384519
Inhibition (functional) = 24 % Parasympatholytic activity was assessed from the ability to inhibit electrically stimulated contraction of isolated guinea pig ileum at 4 mg/L of base ChEMBL. 6384519

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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