TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 416.921 | Formula: C22H27ClN3O3-
H donors: 1 H acceptors: 2 LogP: 4.86 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1c(C)cccc1C)Oc1ccc2c(c1)[C@]1(C)CC[N+]([C@H]1N2C)([O-])C.[Cl-]
InChi: 1S/C22H27N3O3.ClH/c1-14-7-6-8-15(2)19(14)23-21(26)28-16-9-10-18-17(13-16)22(3)11-12-25(5,27)20(22)24(18)4;/h6-10,13,20H,11-12H2,1-5H3,(H,23,26);1H/p-1/t20-,22-,25?;/m0./s1
InChiKey: VXGUMUCYPRASGK-QFPJJMDASA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	jmjC domain containing protein	0.0191	0.0815	0.1091
Mycobacterium ulcerans	hypothetical protein	0.0154	0.0633	0.5374
Brugia malayi	MH2 domain containing protein	0.0076	0.0259	0.0346
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.02	0.0297
Leishmania major	mitochondrial DNA polymerase beta	0.0292	0.13	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0359	0.1626	0.2176
Schistosoma mansoni	hypothetical protein	0.0246	0.1077	0.16
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0159	0.0657	0.0657
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.009	0.0326	0.0437
Echinococcus granulosus	survival motor neuron protein 1	0.0494	0.2275	0.2275
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Echinococcus multilocularis	survival motor neuron protein 1	0.0494	0.2275	0.2275
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0076	0.0259	0.0259
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0159	0.0657	0.5052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0461
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0637	0.2966	0.3969
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0064	0.02	0.0297
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0058	0.0173	0.0256
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0021	0.0028
Brugia malayi	TAR-binding protein	0.0065	0.0203	0.0272
Echinococcus multilocularis	Smad4	0.0076	0.0259	0.0259
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.004	0.0084	0.0084
Echinococcus granulosus	importin subunit beta 1	0.006	0.0178	0.0178
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0066	0.0207	0.1592
Mycobacterium ulcerans	glutaminase	0.0264	0.1166	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0088	0.068
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0025	0.0013	0.0017
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0244	0.1876
Brugia malayi	RNA, U transporter 1	0.017	0.0709	0.0949
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0232	0.0232
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0084	0.0084
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0159	0.0657	0.5052
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0084	0.0113
Brugia malayi	jmjC domain containing protein	0.0074	0.0248	0.0332
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0055	0.0073
Onchocerca volvulus	Huntingtin homolog	0.0133	0.0533	0.1057
Onchocerca volvulus	Huntingtin homolog	0.0133	0.0533	0.1057
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.004	0.0084	0.0084
Echinococcus multilocularis	cpg binding protein	0.0061	0.0183	0.0183
Brugia malayi	MH2 domain containing protein	0.112	0.5298	0.709
Schistosoma mansoni	hypothetical protein	0.0521	0.2405	0.3574
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Loa Loa (eye worm)	hypothetical protein	0.0029	0.003	0.004
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.0582	0.9191
Trichomonas vaginalis	glutaminase, putative	0.0264	0.1166	0.156
Leishmania major	phosphopantetheinyl transferase-like protein	0.0025	0.0013	0.0099
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.014	0.0566	0.0758
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.044	0.2014	0.2695
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0203	0.0272
Schistosoma mansoni	smad	0.0076	0.0259	0.0384
Trypanosoma brucei	DNA polymerase eta, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Trypanosoma cruzi	target of rapamycin kinase 3	0.013	0.0519	0.3991
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0183	0.0183
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0055	0.0073
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0461
Echinococcus granulosus	lysine specific demethylase 5A	0.0074	0.0248	0.0248
Loa Loa (eye worm)	jmjC domain-containing protein	0.0074	0.0248	0.0332
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0203	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0025
Echinococcus multilocularis	dna polymerase eta	0.004	0.0084	0.0084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0106	0.04	0.0536
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0111	0.0428	0.0428
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0048	0.0124	0.0166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.0657	0.0879
Leishmania major	importin beta-1 subunit, putative	0.0048	0.0124	0.0952
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Echinococcus granulosus	intermediate filament protein	0.0027	0.0021	0.0021
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.02	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0081	0.0108
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0034	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0114	0.0439	0.0588
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.004	0.0084	0.0113
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0114	0.0439	0.0439
Schistosoma mansoni	hypothetical protein	0.0111	0.0428	0.0636
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0066	0.0207	0.1592
Plasmodium vivax	SET domain protein, putative	0.0064	0.02	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Schistosoma mansoni	hypothetical protein	0.0101	0.0376	0.056
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0013	0.0643
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.003	0.1677
Echinococcus multilocularis	tumor protein p63	0.2093	1	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0674	0.0902
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0191	0.0815	0.0815
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0074	0.0248	0.0368
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.1587	0.7558	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0048	0.0124	0.0952
Trypanosoma brucei	unspecified product	0.004	0.0084	0.0648
Trypanosoma brucei	importin beta-1 subunit, putative	0.006	0.0178	0.1371
Leishmania major	hypothetical protein, conserved	0.0029	0.003	0.023
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Echinococcus multilocularis	muscleblind protein 1	0.0162	0.0674	0.0674
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Echinococcus multilocularis	peregrin	0.0058	0.0173	0.0173
Echinococcus granulosus	snurportin 1	0.0637	0.2966	0.2966
Toxoplasma gondii	hypothetical protein	0.0047	0.0117	0.0155
Loa Loa (eye worm)	Smad1	0.0076	0.0259	0.0346
Brugia malayi	MH2 domain containing protein	0.0034	0.0055	0.0073
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0013	0.0721
Echinococcus granulosus	jumonji domain containing protein	0.0081	0.0283	0.0283
Echinococcus multilocularis	GPCR, family 2	0.0114	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0439	0.0588
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0101	0.038	0.0509
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.0566	0.0842
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0142	0.0189
Leishmania major	cathepsin L-like protease	0.0073	0.0244	0.1876
Loa Loa (eye worm)	glutaminase 2	0.0264	0.1166	0.156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Leishmania major	cathepsin L-like protease	0.0073	0.0244	0.1876
Schistosoma mansoni	importin beta-1	0.006	0.0178	0.0265
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.02	0.0297
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0124	0.049	0.0728
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.014	0.0566	0.0566
Schistosoma mansoni	lamin	0.0027	0.0021	0.0031
Echinococcus granulosus	dna polymerase kappa	0.004	0.0084	0.0084
Schistosoma mansoni	hypothetical protein	0.0029	0.0028	0.0042
Brugia malayi	latrophilin 2 splice variant baaae	0.0246	0.1077	0.1441
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0259	0.0384
Echinococcus multilocularis	importin subunit beta 1	0.006	0.0178	0.0178
Entamoeba histolytica	deoxycytidyl transferase, putative	0.004	0.0084	0.0644
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0066	0.0207	0.0207
Onchocerca volvulus		0.0306	0.137	0.2785
Loa Loa (eye worm)	hypothetical protein	0.01	0.0374	0.0501
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0159	0.0657	0.0657
Echinococcus granulosus	microtubule associated protein 2	0.1416	0.6728	0.6728
Entamoeba histolytica	hypothetical protein	0.0111	0.0428	0.3272
Brugia malayi	intermediate filament protein	0.0027	0.0021	0.0028
Brugia malayi	Pre-SET motif family protein	0.0064	0.02	0.0268
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Echinococcus multilocularis	muscleblind protein	0.0162	0.0674	0.0674
Schistosoma mansoni	Smad4	0.0076	0.0259	0.0384
Schistosoma mansoni	cpg binding protein	0.0061	0.0183	0.0273
Onchocerca volvulus		0.05	0.2307	0.4718
Trichomonas vaginalis	set domain proteins, putative	0.05	0.2307	0.3087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0069	0.0092
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0029	0.0028	0.0028
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0244	0.1876
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0203	0.0272
Loa Loa (eye worm)	nuclear factor I	0.0042	0.0094	0.0126
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0159	0.0657	0.0879
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0101	0.0376	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0038
Schistosoma mansoni	cellular tumor antigen P53	0.0306	0.137	0.2036
Echinococcus granulosus	muscleblind protein	0.0162	0.0674	0.0674
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.0633	1
Brugia malayi	MH1 domain containing protein	0.0076	0.0259	0.0346
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.014	0.0566	0.0566
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0066	0.0207	0.1592
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0114	0.0439	0.0588
Echinococcus granulosus	cpg binding protein	0.0061	0.0183	0.0183
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0694
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0292	0.13	1
Loa Loa (eye worm)	transcription factor SMAD2	0.112	0.5298	0.709
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0114	0.0439	0.0439
Brugia malayi	MH1 domain containing protein	0.0076	0.0259	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0037	0.0069	0.0102
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0159	0.0657	0.5052
Brugia malayi	PHD-finger family protein	0.0058	0.0173	0.0231
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0052	0.0142	0.0189
Echinococcus granulosus	peregrin	0.0058	0.0173	0.0173
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0064	0.02	0.0265
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0111	0.0427	0.0565
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0094	0.0126
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.004	0.0084	0.0125
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.007	0.0228	0.1752
Schistosoma mansoni	survival motor neuron protein	0.0101	0.0376	0.056
Entamoeba histolytica	hypothetical protein	0.0052	0.0142	0.1082
Loa Loa (eye worm)	hypothetical protein	0.009	0.0326	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.157	0.7473	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Plasmodium falciparum	importin beta, putative	0.006	0.0178	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.0557	0.4287
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0132	0.1013
Leishmania major	cathepsin L-like protease	0.0073	0.0244	0.1876
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0066	0.0207	0.1592
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0123	0.0483	0.0639
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.0084	0.1152
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	0.13	1
Schistosoma mansoni	hypothetical protein	0.0114	0.0439	0.0653
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0293	0.1307	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.013	0.0519	0.3991
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Onchocerca volvulus		0.0101	0.0376	0.0734
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0055	0.0073
Schistosoma mansoni	hypothetical protein	0.0114	0.0439	0.0653
Echinococcus multilocularis	snurportin 1	0.0637	0.2966	0.2966
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0159	0.0657	0.5052
Toxoplasma gondii	FATC domain-containing protein	0.0052	0.0142	0.0187
Brugia malayi	MH1 domain containing protein	0.0042	0.0094	0.0126
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.003	0.023
Loa Loa (eye worm)	MH1 domain-containing protein	0.0076	0.0259	0.0346
Echinococcus granulosus	serine protein kinase ATM	0.0052	0.0142	0.0142
Giardia lamblia	Fructose-bisphosphate aldolase	0.0293	0.1307	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0191	0.0815	0.0815
Schistosoma mansoni	jumonji domain containing protein	0.0152	0.0625	0.0929
Schistosoma mansoni	terminal deoxycytidyl transferase	0.004	0.0084	0.0125
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0028	0.0024	0.0183
Onchocerca volvulus		0.0057	0.0168	0.0303
Trypanosoma brucei	unspecified product	0.0028	0.0024	0.0185
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0084	0.0619
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Schistosoma mansoni	cpg binding protein	0.0061	0.0183	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0021	0.0028
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0168	0.1294
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0292	0.13	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0244	0.1876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Schistosoma mansoni	smad	0.0034	0.0055	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Trichomonas vaginalis	glucosylceramidase, putative	0.1085	0.5133	0.6869
Brugia malayi	MH2 domain containing protein	0.0076	0.0259	0.0346
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0067	0.0213	0.164
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1077	0.1441
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0039	0.0081	0.062
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0674	0.0902
Echinococcus granulosus	lamin	0.0027	0.0021	0.0021
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Schistosoma mansoni	transcription factor LCR-F1	0.0111	0.0428	0.0636
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Echinococcus multilocularis	musashi	0.0027	0.0021	0.0021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0076	0.0259	0.0384
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0159	0.0657	0.5052
Entamoeba histolytica	hypothetical protein	0.0111	0.0428	0.3272
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0024	0.0185
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0173	0.8628
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0008	0.001
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0029	0.0028	0.0028
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0041	0.0089	0.0118
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0025	0.0013	0.0017
Loa Loa (eye worm)	hypothetical protein	0.004	0.0084	0.0113
Brugia malayi	Bromodomain containing protein	0.0058	0.0173	0.0231
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0259	0.0384
Schistosoma mansoni	hypothetical protein	0.0637	0.2966	0.4408
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0533	0.0713
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0084	0.0113
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.007	0.0227	0.175
Trichomonas vaginalis	importin beta-1, putative	0.0048	0.0124	0.0166
Echinococcus granulosus	geminin	0.0521	0.2405	0.2405
Brugia malayi	F/Y-rich N-terminus family protein	0.0039	0.0078	0.0105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0088	0.068
Echinococcus granulosus	histone lysine methyltransferase setb	0.0064	0.02	0.02
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0037	0.0069	0.0526
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.003	0.1495
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Giardia lamblia	GTOR	0.0159	0.0657	0.5023
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0052	0.0142	0.1089
Brugia malayi	glutaminase DH11.1	0.0264	0.1166	0.156
Schistosoma mansoni	hypothetical protein	0.0521	0.2405	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0008	0.001
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0101	0.038	0.0509
Trypanosoma brucei	importin beta-1 subunit, putative	0.006	0.0178	0.1371
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0244	0.1876
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0089	0.0119
Schistosoma mansoni	lamin	0.0027	0.0021	0.0031
Entamoeba histolytica	protein kinase rad3, putative	0.0037	0.0069	0.0526
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.009	0.0326	0.0485
Trichomonas vaginalis	glucosylceramidase, putative	0.1085	0.5133	0.6869
Treponema pallidum	fructose-bisphosphate aldolase	0.0293	0.1307	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0074	0.0248	0.0368
Loa Loa (eye worm)	PHD-finger family protein	0.0058	0.0173	0.0231
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.0557	0.4287
Brugia malayi	hypothetical protein	0.0111	0.0428	0.0572
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0066	0.0207	0.0277
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0089	0.0119
Echinococcus multilocularis	L aminoadipate semialdehyde	0.009	0.0326	0.0326
Echinococcus multilocularis	jumonji domain containing protein	0.0081	0.0283	0.0283
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0021	0.0028
Leishmania major	DNA polymerase eta, putative	0.004	0.0084	0.0648
Brugia malayi	mothers against decapentaplegic homolog 3	0.0034	0.0055	0.0073
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0066	0.0207	0.0307
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.003	0.023
Trichomonas vaginalis	glucosylceramidase, putative	0.157	0.7473	1
Echinococcus granulosus	mothers against decapentaplegic 2	0.0034	0.0055	0.0055
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.0173	0.0228
Brugia malayi	Importin beta-1 subunit	0.006	0.0178	0.0239
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.0566	0.0842
Brugia malayi	hypothetical protein	0.0494	0.2275	0.3044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.0657	0.0879
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0359	0.1626	0.2176
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0203	0.0272
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0021	0.0031
Giardia lamblia	PHD finger protein 15	0.0058	0.0173	0.132
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.0582	0.494
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Loa Loa (eye worm)	MH2 domain-containing protein	0.112	0.5298	0.709
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0024	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0533	0.0713
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.004	0.0084	0.0113
Echinococcus granulosus	smad	0.0076	0.0259	0.0259
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0064	0.02	0.02
Echinococcus granulosus	L aminoadipate semialdehyde	0.009	0.0326	0.0326
Loa Loa (eye worm)	jmjC domain-containing protein	0.0121	0.0473	0.0633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Loa Loa (eye worm)	MH2 domain-containing protein	0.0076	0.0259	0.0346
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0028	0.0024	0.0183
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.014	0.0566	0.0566
Trypanosoma brucei	unspecified product	0.0028	0.0024	0.0185
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0159	0.0657	0.0976
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0066	0.0207	0.1592
Plasmodium vivax	importin-beta 2, putative	0.006	0.0178	0.8913
Brugia malayi	FAT domain containing protein	0.0029	0.0028	0.0038
Entamoeba histolytica	hypothetical protein	0.0111	0.0428	0.3272
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0114	0.0439	0.0439
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.003	0.004
Onchocerca volvulus	Alhambra homolog	0.0058	0.0173	0.0313
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0025	0.0013	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0111	0.0428	0.0428
Brugia malayi	RNA binding protein	0.0065	0.0203	0.0272
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0084	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0494	0.2275	0.3044
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0359	0.1626	0.2176
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0159	0.0657	0.5023
Echinococcus multilocularis	serine protein kinase ATM	0.0052	0.0142	0.0142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Echinococcus multilocularis	lamin	0.0027	0.0021	0.0021
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.1307	0.1749
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0114	0.0439	0.0439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.0657	0.0879
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.0173	0.0228
Brugia malayi	hypothetical protein	0.0133	0.0533	0.0713
Schistosoma mansoni	cpg binding protein	0.0057	0.0168	0.0249
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0021	0.0028
Schistosoma mansoni	Smad4	0.0034	0.0055	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0028	0.0038
Plasmodium falciparum	phd finger protein, putative	0.0058	0.0173	0.968
Entamoeba histolytica	hypothetical protein	0.0025	0.0013	0.0098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0462
Schistosoma mansoni	microtubule-associated protein tau	0.1416	0.6728	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0088	0.068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0244	0.1876
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.013	0.0519	0.3991
Echinococcus multilocularis	lamin dm0	0.0027	0.0021	0.0021
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.014	0.0566	0.0566
Brugia malayi	Muscleblind-like protein	0.0162	0.0674	0.0902
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0168	0.0224
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0064	0.02	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0101	0.038	0.0509
Schistosoma mansoni	hypothetical protein	0.0114	0.0439	0.0653
Entamoeba histolytica	hypothetical protein	0.0111	0.0428	0.3272
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0138	0.0557	0.4287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0345	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0069	0.0092
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Echinococcus granulosus	Smad4	0.0076	0.0259	0.0259
Onchocerca volvulus		0.009	0.0326	0.0631
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0037
Giardia lamblia	DINP protein human, muc B family	0.004	0.0084	0.0644
Brugia malayi	Latrophilin receptor protein 2	0.0114	0.0439	0.0588
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Schistosoma mansoni	DNA polymerase eta	0.004	0.0084	0.0125
Entamoeba histolytica	hypothetical protein	0.0048	0.0124	0.0947
Leishmania major	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0034	0.0055	0.0055
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0159	0.0657	0.5023
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0037	0.0069	0.0069
Schistosoma mansoni	smad1 5 8 and	0.0076	0.0259	0.0384
Schistosoma mansoni	glutaminase	0.0264	0.1166	0.1733
Trichomonas vaginalis	glucosylceramidase, putative	0.103	0.4865	0.6511
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0066	0.0207	0.1592
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0203	0.0203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.013	0.0518	0.0693
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0037	0.0069	0.0529
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0024	0.0185
Echinococcus multilocularis	microtubule associated protein 2	0.1416	0.6728	0.6728
Echinococcus granulosus	dna polymerase eta	0.004	0.0084	0.0084
Loa Loa (eye worm)	phosphatidylinositol 3	0.0159	0.0657	0.0879
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.014	0.0566	0.0758
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0293	0.1307	1
Brugia malayi	Pre-SET motif family protein	0.044	0.2014	0.2695
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0037	0.0069	0.0092
Toxoplasma gondii	HEAT repeat-containing protein	0.006	0.0178	0.0236
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0089	0.0119
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Onchocerca volvulus	Glucosylceramidase homolog	0.103	0.4865	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0168	0.0224
Brugia malayi	Smad1	0.0076	0.0259	0.0346
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.003	0.1677
Schistosoma mansoni	hypothetical protein	0.0114	0.0439	0.0653
Loa Loa (eye worm)	phosphatidylinositol 3	0.0066	0.0207	0.0277
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.004	0.0084	0.0648
Trypanosoma cruzi	DNA polymerase eta, putative	0.004	0.0084	0.0648
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.157	0.7473	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0048	0.0124	0.0166
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0034	0.0055	0.007
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0088	0.068
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0052	0.0142	0.021
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.003	0.023
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0037	0.0069	0.0069
Echinococcus granulosus	GPCR family 2	0.0114	0.0439	0.0439
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0159	0.0657	0.5052
Brugia malayi	MH1 domain containing protein	0.0042	0.0094	0.0126
Echinococcus granulosus	PHD finger protein rhinoceros	0.0058	0.0173	0.0173
Brugia malayi	hypothetical protein	0.0029	0.003	0.004
Echinococcus multilocularis	geminin	0.0521	0.2405	0.2405
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0066	0.0207	0.0207
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.004	0.0084	0.1152
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0076	0.0259	0.0259
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Schistosoma mansoni	hypothetical protein	0.0058	0.0173	0.0256
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0203	0.0302
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0076	0.0259	0.0259
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0036	0.0063	0.0093
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0084	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Echinococcus granulosus	lamin dm0	0.0027	0.0021	0.0021
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0058	0.0173	0.0173
Trichomonas vaginalis	DNA polymerase eta, putative	0.004	0.0084	0.0113
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.0582	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.0566	0.0842
Loa Loa (eye worm)	glutaminase	0.0264	0.1166	0.156
Schistosoma mansoni	Smad4	0.0034	0.0055	0.0081
Echinococcus granulosus	mothers against decapentaplegic 6	0.0034	0.0055	0.0055
Echinococcus granulosus	mothers against decapentaplegic 5	0.0076	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0359	0.1626	0.2176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0483	0.0647
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0052	0.0142	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0064	0.02	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0173	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0306	0.137	0.1833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0069	0.0092
Loa Loa (eye worm)	hypothetical protein	0.006	0.0178	0.0239
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0207	0.0277
Echinococcus multilocularis	smad	0.0076	0.0259	0.0259
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0013	0.0099
Onchocerca volvulus		0.0064	0.02	0.037
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0025	0.0013	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 186 uM	Inhibition of Torpedo californica AChE	ChEMBL.	16913695
Inhibition (binding)	= 13 %	Inhibition of AChE in CD1 mouse brain at 11 mg/kg, po after 6 hrs	ChEMBL.	16913695

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 456113

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 371044