Detailed information for compound 371370

Basic information

Technical information
  • TDR Targets ID: 371370
  • Name: 9-bromo-2-(4-methoxyphenyl)-1'-propylspiro[1, 10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5, 4'-piperidine]
  • MW: 470.402 | Formula: C24H28BrN3O2
  • H donors: 0 H acceptors: 0 LogP: 5.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CCC2(CC1)Oc1ccc(cc1C1N2N=C(C1)c1ccc(cc1)OC)Br
  • InChi: 1S/C24H28BrN3O2/c1-3-12-27-13-10-24(11-14-27)28-22(20-15-18(25)6-9-23(20)30-24)16-21(26-28)17-4-7-19(29-2)8-5-17/h4-9,15,22H,3,10-14,16H2,1-2H3
  • InChiKey: DZZXFSLRKYTBEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 9-bromo-2-(4-methoxyphenyl)-1'-propyl-spiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]
  • STOCK3S-03394
  • Oprea1_519017

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Echinococcus granulosus hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus carbonic anhydrase II 0.1096 0.5617 0.5614
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0045 0.0097 0.0173
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1096 0.5617 0.5617
Schistosoma mansoni sodium/chloride dependent transporter 0.0043 0.0088 0.0082
Onchocerca volvulus 0.0041 0.0076 0.007
Echinococcus multilocularis voltage dependent calcium channel 0.004 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0413 0.0407
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.053 0.2642 0.2642
Echinococcus multilocularis slit 2 protein 0.0366 0.1779 0.1774
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0195 0.0883 0.0883
Echinococcus multilocularis peroxidasin 0.1931 1 1
Plasmodium falciparum carbonic anhydrase 0.053 0.2642 0.688
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0105 0.0413 0.0407
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.067 0.0664
Brugia malayi Trypsin family protein 0.0105 0.0413 0.0413
Onchocerca volvulus Peroxidase homolog 0.1931 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0041 0.0076 0.007
Echinococcus granulosus peroxidasin 0.1931 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) norepinephrine transporter 0.0243 0.1134 0.1134
Schistosoma mansoni hypothetical protein 0.0366 0.1779 0.1774
Echinococcus granulosus protein jagged 2 0.0366 0.1779 0.1774
Schistosoma mansoni hypothetical protein 0.0366 0.1779 0.1774
Trypanosoma brucei carbonic anhydrase-like protein 0.1096 0.5617 1
Plasmodium falciparum amino acid transporter, putative 0.0041 0.0076 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0755 0.3826 0.6811
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1224 0.6288 1
Brugia malayi GCC2 and GCC3 family protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) serotonin transporter b 0.0243 0.1134 0.1134
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0045 0.0097 0.0091
Echinococcus granulosus hypothetical protein 0.0847 0.4309 0.4306
Brugia malayi ecdysteroid receptor 0.0028 0.0006 0.0006
Brugia malayi Animal haem peroxidase family protein 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0105 0.0413 0.0413
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0164 0.0721 0.132
Echinococcus multilocularis fat cadherin tumor suppressor 0.0366 0.1779 0.1774
Echinococcus granulosus notch 0.0366 0.1779 0.1774
Brugia malayi Peroxidasin 0.1931 1 1
Schistosoma mansoni carbonic anhydrase 0.1224 0.6288 0.6286
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0413 0.0407
Echinococcus multilocularis fibropellin Ia 0.0366 0.1779 0.1774
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.053 0.2642 0.2642
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.0076 0.007
Echinococcus multilocularis mitogen activated protein kinase 11 0.0128 0.0533 0.0527
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0481 0.0475
Echinococcus multilocularis Mastin 0.0105 0.0413 0.0407
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0045 0.0097 0.0173
Schistosoma mansoni peroxidasin 0.1931 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0006 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0366 0.1779 0.1774
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0045 0.0097 0.0091
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0076 0.007
Onchocerca volvulus Dual oxidase homolog 0.1931 1 1
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0031 0.0055
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0045 0.0097 0.0091
Echinococcus granulosus carbonic anhydrase 0.053 0.2642 0.2637
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.0076 0.007
Schistosoma mansoni carbonic anhydrase-related 0.053 0.2642 0.2637
Leishmania major hypothetical protein, conserved 0.0755 0.3826 0.6084
Brugia malayi Kringle domain containing protein 0.0755 0.3826 0.3826
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0076 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Onchocerca volvulus 0.0105 0.0413 0.0407
Schistosoma mansoni hypothetical protein 0.0366 0.1779 0.1774
Brugia malayi EGF-like domain containing protein 0.0366 0.1779 0.1779
Brugia malayi EGF-like domain containing protein 0.0366 0.1779 0.1779
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0413 0.0407
Schistosoma mansoni carbonic anhydrase-related 0.053 0.2642 0.2637
Echinococcus granulosus delta-like protein 1 0.0366 0.1779 0.1774
Brugia malayi Animal haem peroxidase family protein 0.1931 1 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0366 0.1779 0.1779
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.004 0.0072 0.0066
Brugia malayi Cytochrome P450 family protein 0.0076 0.026 0.026
Schistosoma mansoni laminin gamma-3 chain 0.0366 0.1779 0.1774
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Schistosoma mansoni notch 0.0366 0.178 0.1775
Schistosoma mansoni hypothetical protein 0.0126 0.0523 0.0517
Onchocerca volvulus Chorion peroxidase homolog 0.1931 1 1
Schistosoma mansoni cytochrome c oxidase subunit II 0.0122 0.0502 0.0496
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0027 0.0002 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0006 0.0006
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.004 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.0755 0.3826 0.3826
Toxoplasma gondii hypothetical protein 0.0041 0.0076 0.0118
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0413 0.0407
Brugia malayi Delta serrate ligand family protein 0.0366 0.1779 0.1779
Mycobacterium ulcerans integral membrane transporter 0.0033 0.0031 0.0042
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0105 0.0413 0.0413
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0006 0.0006
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.004 0.0072 0.0066
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0076 0.0076
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0076 0.0076
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0128 0.0533 0.0949
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0071 0.023 0.2761
Mycobacterium leprae PROBABLE TRANSFERASE 0.0068 0.0216 0.0341
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0045 0.0097 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Echinococcus granulosus transmembrane protease serine 3 0.0105 0.0413 0.0407
Loa Loa (eye worm) hypothetical protein 0.0105 0.0413 0.0413
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.0076 0.007
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0523 0.0517
Entamoeba histolytica protein kinase, putative 0.0195 0.0883 0.1305
Brugia malayi Blistered cuticle protein 3 0.1931 1 1
Brugia malayi steroid hormone receptor 0.0028 0.0006 0.0006
Brugia malayi Calcium binding EGF domain containing protein 0.0366 0.1779 0.1779
Onchocerca volvulus 0.0243 0.1134 0.1128
Loa Loa (eye worm) animal heme peroxidase 0.1931 1 1
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0045 0.0097 0.005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Onchocerca volvulus 0.0366 0.1779 0.1774
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.053 0.2642 0.2642
Schistosoma mansoni thyroid hormone receptor 0.0154 0.067 0.0664
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Loa Loa (eye worm) blistered cuticle protein 3 0.1931 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1096 0.5617 1
Onchocerca volvulus 0.1931 1 1
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0682 0.344 0.6855
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Echinococcus granulosus serotonin transporter 0.0243 0.1134 0.1128
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0076 0.007
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0076 0.007
Brugia malayi EGF-like domain containing protein 0.0366 0.1779 0.1779
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0237 0.1103 0.2097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Brugia malayi Cadherin domain containing protein 0.0366 0.1779 0.1779
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.004 0.0072 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0006 0.0006
Giardia lamblia High cysteine protein 0.0366 0.1779 0.5
Echinococcus granulosus protein jagged 2 0.0366 0.1779 0.1774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0006 0.0006
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Echinococcus granulosus protein jagged 1 0.0366 0.1779 0.1774
Echinococcus multilocularis carbonic anhydrase 0.053 0.2642 0.2637
Echinococcus granulosus protein jagged 1 0.0366 0.1779 0.1774
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0195 0.0883 0.0939
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0071 0.023 0.2761
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0076 0.0118
Echinococcus multilocularis protein jagged 1 0.0366 0.1779 0.1774
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0413 0.0407
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0243 0.1134 0.1128
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.0076 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Loa Loa (eye worm) hypothetical protein 0.053 0.2642 0.2642
Echinococcus multilocularis mitogen activated protein kinase 11 0.0128 0.0533 0.0527
Echinococcus granulosus slit 2 protein 0.0366 0.1779 0.1774
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0243 0.1134 0.1134
Entamoeba histolytica ankyrin, putative 0.0071 0.0231 0.0255
Schistosoma mansoni lipoxygenase 0.0118 0.0481 0.0475
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Schistosoma mansoni slit 0.0366 0.1779 0.1774
Onchocerca volvulus 0.0041 0.0076 0.007
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0045 0.0097 0.0132
Loa Loa (eye worm) solute carrier family 6 member 4 0.0243 0.1134 0.1134
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0031 0.0055
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.0076 0.0076
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.4236 0.4232
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0006 0.0006
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0366 0.1779 0.1774
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0006 0.0006
Echinococcus multilocularis serotonin transporter 0.0243 0.1134 0.1128
Toxoplasma gondii hypothetical protein 0.0036 0.0046 0.004
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0413 0.0407
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0243 0.1134 0.1128
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Echinococcus granulosus glycoprotein Antigen 5 0.0105 0.0413 0.0407
Entamoeba histolytica acetyltransferase, putative 0.0071 0.023 0.0254
Loa Loa (eye worm) trypsin family protein 0.0105 0.0413 0.0413
Loa Loa (eye worm) animal heme peroxidase 0.1931 1 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.004 0.0072 0.0128
Schistosoma mansoni hypothetical protein 0.0755 0.3826 0.3822
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.004 0.0072 0.0066
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.053 0.2642 0.2642
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0104 0.0407 0.0991
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0755 0.3826 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0076 0.0118
Schistosoma mansoni hypothetical protein 0.017 0.0753 0.0747
Schistosoma mansoni notch 0.0366 0.1779 0.1774
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0076 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0883 0.0878
Brugia malayi Muscle positioning protein 4 0.0366 0.1779 0.1779
Onchocerca volvulus 0.0366 0.1779 0.1774
Echinococcus granulosus neural cadherin 0.0366 0.1779 0.1774
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1096 0.5617 0.5614
Echinococcus multilocularis protein jagged 1 0.0366 0.1779 0.1774
Onchocerca volvulus Peroxidasin homolog 0.1931 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.017 0.0753 0.0747
Mycobacterium ulcerans transferase 0.0068 0.0216 0.0295
Echinococcus granulosus geminin 0.017 0.0753 0.0747
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0195 0.0883 0.0878
Toxoplasma gondii hypothetical protein 0.0041 0.0076 0.0118
Toxoplasma gondii transporter, cation channel family protein 0.004 0.0072 0.0107
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.026 0.026
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.0076 0.0076
Echinococcus granulosus cytochrome c oxidase subunit II 0.0149 0.0644 0.0639
Loa Loa (eye worm) hypothetical protein 0.0243 0.1134 0.1134
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.0076 0.007
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.053 0.2642 0.2642
Brugia malayi Animal haem peroxidase family protein 0.1931 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Schistosoma mansoni cell polarity protein 0.0366 0.1779 0.1774
Mycobacterium ulcerans hypothetical protein 0.0105 0.0413 0.0564
Loa Loa (eye worm) animal heme peroxidase 0.1931 1 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0755 0.3826 1
Mycobacterium ulcerans carbonic anhydrase 0.1421 0.7324 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0041 0.0076 0.007
Loa Loa (eye worm) calcium channel 0.004 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) Notch2 0.0366 0.1779 0.1779
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0045 0.0097 0.0173
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Brugia malayi Protein kinase domain containing protein 0.0195 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Onchocerca volvulus 0.0105 0.0413 0.0407
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1096 0.5617 0.5617
Brugia malayi Animal haem peroxidase family protein 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Echinococcus multilocularis carbonic anhydrase 0.053 0.2642 0.2637
Loa Loa (eye worm) hypothetical protein 0.0105 0.0413 0.0413
Loa Loa (eye worm) TK/ROR protein kinase 0.0755 0.3826 0.3826
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0149 0.0644 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Onchocerca volvulus 0.0105 0.0413 0.0407
Onchocerca volvulus 0.0105 0.0413 0.0407
Onchocerca volvulus Peroxidasin homolog 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Brugia malayi Trypsin-like protease protein 5 0.0105 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0041 0.0076 1
Schistosoma mansoni hypothetical protein 0.0366 0.1779 0.1774
Brugia malayi EGF-like domain containing protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Onchocerca volvulus Slit protein homolog 0.0366 0.1779 0.1774
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0195 0.0883 0.0883
Echinococcus granulosus mitogen activated protein kinase 14 0.0128 0.0533 0.0527
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Brugia malayi Trypsin family protein 0.0105 0.0413 0.0413
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0128 0.0533 0.0949
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.004 0.0072 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0072 0.0129
Schistosoma mansoni hypothetical protein 0.053 0.2642 0.2637
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0006 0.0006
Echinococcus granulosus voltage dependent calcium channel 0.004 0.0072 0.0066
Echinococcus multilocularis enteropeptidase 0.0105 0.0413 0.0407
Toxoplasma gondii kringle domain-containing protein 0.0755 0.3826 1
Schistosoma mansoni peroxidasin 0.1931 1 1
Brugia malayi hypothetical protein 0.0105 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0523 0.0517
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Echinococcus granulosus enteropeptidase 0.0105 0.0413 0.0407
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0031 0.0055
Schistosoma mansoni notch 0.0366 0.1779 0.1774
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0006 0.0006
Schistosoma mansoni voltage-gated cation channel 0.004 0.0072 0.0066
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0413 0.0407
Onchocerca volvulus 0.0205 0.0936 0.093
Loa Loa (eye worm) hypothetical protein 0.1123 0.5759 0.5759
Echinococcus multilocularis mitogen activated protein kinase 14 0.0128 0.0533 0.0527
Onchocerca volvulus 0.0068 0.0216 0.021
Schistosoma mansoni carbonic anhydrase-related 0.053 0.2642 0.2637
Brugia malayi Calcium binding EGF domain containing protein 0.0366 0.1779 0.1779
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0006 0.0006
Echinococcus granulosus carbonic anhydrase 0.053 0.2642 0.2637
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.0076 0.007
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.004 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0105 0.0413 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0006 0.0006
Brugia malayi Trypsin family protein 0.0105 0.0413 0.0413
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0041 0.0076 0.007
Echinococcus granulosus tissue type plasminogen activator 0.0755 0.3826 0.3822
Trichomonas vaginalis AGC family protein kinase 0.0195 0.0883 0.0939
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0076 0.007
Mycobacterium ulcerans carbonic anhydrase 0.1224 0.6288 0.8586
Onchocerca volvulus Peroxidase homolog 0.1931 1 1
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0031 0.0042
Echinococcus granulosus neurogenic locus notch protein 4 0.0366 0.1779 0.1774
Schistosoma mansoni hypothetical protein 0.0366 0.1779 0.1774
Brugia malayi EGF-like domain containing protein 0.0366 0.1779 0.1779
Onchocerca volvulus Neurogenic locus notch homolog 0.0366 0.178 0.1775
Brugia malayi Trypsin family protein 0.0105 0.0413 0.0413
Echinococcus multilocularis neurogenic locus notch protein 0.0366 0.1779 0.1774
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.004 0.0072 0.0066
Echinococcus granulosus fibropellin Ia 0.0366 0.1779 0.1774
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.0076 0.007
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0041 0.0076 0.007
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Leishmania major hypothetical protein, conserved 0.004 0.0072 0.0115
Brugia malayi nuclear receptor NHR-88 0.0028 0.0006 0.0006
Echinococcus multilocularis tissue type plasminogen activator 0.0755 0.3826 0.3822
Brugia malayi Cadherin domain containing protein 0.0366 0.1779 0.1779
Brugia malayi nuclear hormone receptor 0.0028 0.0006 0.0006
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0195 0.0883 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0006 0.0006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0076 0.0118
Toxoplasma gondii MAPEG family protein 0.0112 0.0449 0.1102
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0076 0.0076
Brugia malayi Animal haem peroxidase family protein 0.1931 1 1
Plasmodium vivax amine transporter, putative 0.0041 0.0076 0.0118
Onchocerca volvulus 0.0366 0.1779 0.1774
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0041 0.0076 0.0076
Onchocerca volvulus 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Echinococcus multilocularis geminin 0.017 0.0753 0.0747
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1096 0.5617 1
Onchocerca volvulus 0.0366 0.1779 0.1774
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0006 0.0006
Schistosoma mansoni cytochrome-c oxidase 0.0045 0.0097 0.0091
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0112 0.0449 0.0443
Leishmania major carbonic anhydrase family protein, putative 0.1224 0.6288 1
Schistosoma mansoni notch 0.0366 0.1779 0.1774
Schistosoma mansoni microsomal glutathione s-transferase 0.0112 0.0449 0.0443
Echinococcus granulosus microsomal glutathione S transferase 3 0.0112 0.0449 0.0443
Loa Loa (eye worm) animal heme peroxidase 0.1931 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0105 0.0413 0.0413
Echinococcus multilocularis neurogenic locus protein delta 0.0366 0.1779 0.1774
Onchocerca volvulus Putative cubilin 0.0366 0.1779 0.1774
Echinococcus multilocularis protein jagged 2 0.0366 0.1779 0.1774
Mycobacterium leprae Probable transmembrane transport protein 0.0237 0.1103 0.1751
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0041 0.0076 0.007
Brugia malayi follicle stimulating hormone receptor 0.0245 0.1145 0.1145
Brugia malayi P38 map kinase family protein 2 0.0128 0.0533 0.0533
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0105 0.0413 0.0407
Echinococcus multilocularis mitogen activated protein kinase 14 0.0128 0.0533 0.0527
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.053 0.2642 0.2642
Plasmodium falciparum transporter, putative 0.0041 0.0076 0.0118
Schistosoma mansoni notch 0.0366 0.1779 0.1774
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0006 0.0006
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0128 0.0533 0.0533
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0413 0.0407
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0105 0.0413 0.0407
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0072 0.0129
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.049 0.2433 0.2428
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Brugia malayi Calcium binding EGF domain containing protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.1145 0.1145
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0006 0.0006
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1096 0.5617 0.5617
Echinococcus granulosus voltage dependent calcium channel 0.004 0.0072 0.0066
Schistosoma mansoni hypothetical protein 0.0366 0.1779 0.1774
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Toxoplasma gondii hypothetical protein 0.053 0.2642 0.688
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0366 0.1779 0.1774
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0071 0.023 0.0322
Loa Loa (eye worm) carbonic anhydrase 3 0.1096 0.5617 0.5617
Mycobacterium ulcerans epoxide hydrolase EphA 0.0164 0.0721 0.0984
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0105 0.0413 0.0407
Loa Loa (eye worm) hypothetical protein 0.0105 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) hypothetical protein 0.0105 0.0413 0.0413
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0248 0.0242
Brugia malayi hypothetical protein 0.0041 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0072
Leishmania major carbonic anhydrase-like protein 0.1096 0.5617 0.8933
Echinococcus multilocularis carbonic anhydrase II 0.1096 0.5617 0.5614
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Schistosoma mansoni thyroid hormone receptor 0.0154 0.067 0.0664
Trichomonas vaginalis AGC family protein kinase 0.0195 0.0883 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.1421 0.7324 1
Onchocerca volvulus 0.0755 0.3826 0.3822
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.004 0.0072 0.0066
Onchocerca volvulus 0.0105 0.0413 0.0407
Echinococcus granulosus mitogen activated protein kinase 11 0.0128 0.0533 0.0527
Onchocerca volvulus 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Echinococcus granulosus dynactin 5 p25 0.0071 0.023 0.0224
Echinococcus multilocularis carbonic anhydrase 0.053 0.2642 0.2637
Echinococcus granulosus Mastin 0.0105 0.0413 0.0407
Echinococcus multilocularis notch 0.0366 0.1779 0.1774
Loa Loa (eye worm) hypothetical protein 0.0243 0.1134 0.1134
Schistosoma mansoni carbonic anhydrase 0.053 0.2642 0.2637
Brugia malayi EGF-like domain containing protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) notch protein 0.0366 0.1779 0.1779
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.004 0.0072 0.0128
Loa Loa (eye worm) hypothetical protein 0.053 0.2642 0.2642
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0248 0.0242
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0031 0.0042
Echinococcus granulosus carbonic anhydrase 0.053 0.2642 0.2637
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0041 0.0076 0.007
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1096 0.5617 0.5614
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0128 0.0533 0.0847
Echinococcus multilocularis neurogenic locus notch protein 0.0366 0.1779 0.1774
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0072 0.0129
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.0076 0.007
Echinococcus multilocularis voltage dependent calcium channel 0.004 0.0072 0.0066
Brugia malayi phosphoinositide-dependent protein kinase I 0.0195 0.0883 0.0883
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0976 0.4986 1
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Schistosoma mansoni hypothetical protein 0.0105 0.0413 0.0407
Mycobacterium ulcerans hypothetical protein 0.004 0.0072 0.0099
Toxoplasma gondii EGF family domain-containing protein 0.0366 0.1779 0.4606
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.0076 0.007
Schistosoma mansoni notch 0.0366 0.1779 0.1774
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0779 0.3951 0.7893
Onchocerca volvulus 0.0041 0.0076 0.007
Entamoeba histolytica carbonic anhydrase, putative 0.1224 0.6288 1
Onchocerca volvulus 0.0366 0.1779 0.1774
Echinococcus granulosus neurogenic locus notch protein 0.0366 0.1779 0.1774
Schistosoma mansoni hypothetical protein 0.0105 0.0413 0.0407
Echinococcus multilocularis neurogenic locus protein delta 0.0366 0.1779 0.1774
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0072
Schistosoma mansoni cercarial elastase (S01 family) 0.0105 0.0413 0.0407
Onchocerca volvulus 0.0045 0.0097 0.0091
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Echinococcus granulosus neurogenic locus notch protein 0.0366 0.1779 0.1774
Treponema pallidum sodium- and chloride- dependent transporter 0.0243 0.1134 0.5
Loa Loa (eye worm) voltage-dependent calcium channel 0.004 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0076 0.007
Trichomonas vaginalis conserved hypothetical protein 0.1421 0.7324 1
Brugia malayi EGF-like domain containing protein 0.0366 0.1779 0.1779
Onchocerca volvulus 0.0105 0.0413 0.0407
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0128 0.0533 0.0949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0755 0.3826 0.3826
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.004 0.0072 0.0066
Echinococcus multilocularis neurogenic locus notch protein 4 0.0366 0.1779 0.1774
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Echinococcus multilocularis transmembrane protease serine 3 0.0105 0.0413 0.0407
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0481 0.0475
Echinococcus multilocularis glycoprotein Antigen 5 0.0105 0.0413 0.0407
Loa Loa (eye worm) hypothetical protein 0.0366 0.1779 0.1779
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Schistosoma mansoni lipoxygenase 0.0083 0.0294 0.0288
Brugia malayi notch-like transmembrane receptor 0.0366 0.1779 0.1779
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0006
Onchocerca volvulus Putative sulfate transporter 0.0205 0.0936 0.093
Schistosoma mansoni septate junction protein 0.0366 0.1779 0.1774
Echinococcus granulosus neurogenic locus protein delta 0.0366 0.1779 0.1774
Echinococcus multilocularis neural cadherin 0.0366 0.1779 0.1774

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 179 nM Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release ChEMBL. 16844377
IC50 (functional) = 179 nM Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release ChEMBL. 16844377

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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