Detailed information for compound 404339

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1193.41 | Formula: C65H92O20
  • H donors: 0 H acceptors: 4 LogP: 12.1 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1OC2OC3(C)CCC4C2(C(C1CC1(CCCCCCCC2(CC5C(=O)OC6C78C5CCC(C8CCC(O6)(OO7)C)C)C(=O)OC5C67C2CCC(C7CCC(O5)(OO6)C)C)C(=O)OC2C56C1CCC(C6CCC(O2)(OO5)C)C)CCC4C)OO3
  • InChi: 1S/C65H92O20/c1-34-14-18-44-38(48(66)70-52-62(44)40(34)22-28-56(5,74-52)78-82-62)32-60(46-20-16-36(3)42-24-30-58(7)76-54(72-50(60)68)64(42,46)84-80-58)26-12-10-9-11-13-27-61(47-21-17-37(4)43-25-31-59(8)77-55(73-51(61)69)65(43,47)85-81-59)33-39-45-19-15-35(2)41-23-29-57(6)75-53(71-49(39)67)63(41,45)83-79-57/h34-47,52-55H,9-33H2,1-8H3
  • InChiKey: NBJUGGJBVUJNQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Treponema pallidum aminopeptidase P 0.00292631 0.015045 0.0340314
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.018906 0.1606 0.521883
Loa Loa (eye worm) hypothetical protein 0.03498 0.307013 0.584818
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.00439274 0.0284024 0.0786492
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.00292631 0.015045 0.020436
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00865019 0.0671823 0.121219
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Trichomonas vaginalis AGC family protein kinase 0.00444775 0.0289034 0.0479821
Schistosoma mansoni biogenic amine (5HT) receptor 0.00865019 0.0671823 0.121219
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Brugia malayi DNA repair protein RAD51 homolog 1 0.00218767 0.00831696 0.00564695
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.00292631 0.015045 0.020436
Toxoplasma gondii hypothetical protein 0.0475983 0.42195 1
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.00292631 0.015045 0.0496205
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00865019 0.0671823 0.121219
Echinococcus multilocularis cyclin dependent kinase 1 0.00439274 0.0284024 0.0462562
Trypanosoma brucei glycerol uptake protein, putative 0.00181745 0.0049447 0.0163083
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Trichomonas vaginalis CMGC family protein kinase 0.00439274 0.0284024 0.0470142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0030107 0.0158137 0.0226993
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.00935842 0.0736333 0.133689
Toxoplasma gondii target of rapamycin (TOR), putative 0.00229353 0.00928121 0.0115173
Echinococcus granulosus membrane bound acyltransferase:hhat 0.00181745 0.0049447 0.00091181
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Echinococcus granulosus neuropeptide Y receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus Peroxidase homolog 0.00546514 0.0381705 0.0338489
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus multilocularis serotonin receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) animal heme peroxidase 0.00546514 0.0381705 0.0651384
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00851103 0.0659147 0.119469
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.018906 0.1606 0.301798
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0344009 0.301738 1
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.00181745 0.0049447 0.00112988
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Schistosoma mansoni rab6-interacting 0.00204943 0.00705775 0.00499641
Schistosoma mansoni neuropeptide F-like receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus Neuropeptide F receptor homolog 0.00865019 0.0671823 0.062991
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0345919 0.303478 0.577986
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.00411321 0.0258561 0.0404593
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.00260141 0.0120856 0.0147153
Brugia malayi serine/threonine kinase 12 0.00575387 0.0408004 0.0533665
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.00411321 0.0258561 0.0420962
Echinococcus granulosus xaa Pro dipeptidase 0.00292631 0.015045 0.020436
Trichomonas vaginalis PIKK family atypical protein kinase 0.00186815 0.00540653 0.00259794
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.00851103 0.0659147 0.204421
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Toxoplasma gondii RNA-directed DNA polymerase 0.0345615 0.303201 0.715558
Entamoeba histolytica protein kinase, putative 0.00575387 0.0408004 0.0693735
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Entamoeba histolytica DNA repair protein RAD51, putative 0.00218767 0.00831696 0.00652464
Mycobacterium ulcerans transcriptional regulator NrdR 0.00676103 0.0499744 0.155167
Schistosoma mansoni hypothetical protein 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0030107 0.0158137 0.0219218
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0276399 0.240154 1
Brugia malayi sulfakinin receptor protein 0.00865019 0.0671823 0.0921226
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.291014
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00865019 0.0671823 0.121219
Trypanosoma cruzi hypothetical protein, conserved 0.0109616 0.088236 0.27926
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Loa Loa (eye worm) AUR protein kinase 0.00575387 0.0408004 0.0702221
Echinococcus multilocularis neuropeptides capa receptor 0.00865019 0.0671823 0.121219
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0585599 0.521795 1
Schistosoma mansoni peroxidasin 0.00546514 0.0381705 0.0651384
Schistosoma mansoni protein farnesyltransferase subunit beta 0.00411321 0.0258561 0.0413342
Giardia lamblia Rab geranylgeranyltransferase 0.0585599 0.521795 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00865019 0.0671823 0.0921226
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0030107 0.0158137 0.0364416
Brugia malayi follicle stimulating hormone receptor 0.00865019 0.0671823 0.0921226
Trypanosoma cruzi hypothetical protein, conserved 0.00411321 0.0258561 0.0701122
Brugia malayi Hhat protein 0.00181745 0.0049447 0.000692947
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.00575387 0.0408004 0.0693735
Echinococcus multilocularis cyclin dependent kinase 1 0.00439274 0.0284024 0.0462562
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0116319 0.0943417 0.173719
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi G protein-coupled receptor F59B2.13 0.00865019 0.0671823 0.0921226
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0276399 0.240154 1
Brugia malayi Peroxidasin 0.00546514 0.0381705 0.0495031
Trypanosoma cruzi lanosterol synthase, putative 0.00411321 0.0258561 0.0701122
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0368879 0.324392 0.618413
Echinococcus granulosus neuropeptide receptor A26 0.00865019 0.0671823 0.121219
Plasmodium vivax methionine aminopeptidase 1b, putative 0.018906 0.1606 0.301161
Leishmania major protein kinase, putative 0.00575387 0.0408004 0.120218
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.162583
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0368879 0.324392 0.618413
Toxoplasma gondii peptidase D, putative 0.00292631 0.015045 0.0253236
Loa Loa (eye worm) hypothetical protein 0.00204943 0.00705775 0.00499641
Echinococcus multilocularis cyclin dependent kinase 5 0.00439274 0.0284024 0.0462562
Echinococcus granulosus o acyltransferase membrane bound domain 0.00181745 0.0049447 0.00091181
Schistosoma mansoni DNA repair protein RAD51 0.00218767 0.00831696 0.0074305
Echinococcus granulosus cyclin dependent kinase 1 0.00439274 0.0284024 0.0462562
Entamoeba histolytica protein kinase, putative 0.00444775 0.0289034 0.0463552
Loa Loa (eye worm) hypothetical protein 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.00935842 0.0736333 0.133689
Leishmania major transcription factor-like protein 0.00292631 0.015045 0.0338645
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0585599 0.521795 1
Brugia malayi Melatonin receptor type 1A 0.00865019 0.0671823 0.0921226
Echinococcus granulosus Polycystic kidney disease protein 0.00204943 0.00705775 0.00499641
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Echinococcus multilocularis sex peptide receptor 0.00865019 0.0671823 0.121219
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.00411321 0.0258561 0.05122
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Giardia lamblia Aurora kinase 0.00575387 0.0408004 0.0702221
Loa Loa (eye worm) hypothetical protein 0.0585599 0.521795 1
Trichomonas vaginalis AGC family protein kinase 0.00575387 0.0408004 0.0709611
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.018906 0.1606 0.521883
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Trypanosoma brucei cdc2-related kinase 1 0.00439274 0.0284024 0.0936748
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Plasmodium vivax FACT complex subunit SPT16, putative 0.00292631 0.015045 0.019542
Echinococcus granulosus neuropeptide s receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Brugia malayi Protein kinase domain containing protein 0.00439274 0.0284024 0.0351532
Brugia malayi GnHR receptor homolog 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) hypothetical protein 0.00292631 0.015045 0.020436
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.00851103 0.0659147 0.217396
Trypanosoma cruzi cdc2-related kinase 3 0.00439274 0.0284024 0.0786492
Echinococcus granulosus tm gpcr rhodopsin 0.00865019 0.0671823 0.121219
Trypanosoma brucei cdc2-related kinase 3 0.00439274 0.0284024 0.0936748
Schistosoma mansoni adenoreceptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00865019 0.0671823 0.121219
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.00439274 0.0284024 0.0462562
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.00575387 0.0408004 0.0702221
Trypanosoma brucei protein farnesyltransferase beta subunit 0.00411321 0.0258561 0.0852771
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0276399 0.240154 0.456011
Echinococcus multilocularis GPCR, family 2 0.00935842 0.0736333 0.133689
Loa Loa (eye worm) hypothetical protein 0.0295772 0.257801 0.48969
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0344009 0.301738 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.018906 0.1606 0.646597
Plasmodium falciparum LCCL domain-containing protein 0.00204943 0.00705775 0.00408833
Schistosoma mansoni rab6-interacting 0.00204943 0.00705775 0.00499641
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.27926
Schistosoma mansoni neuropeptide f receptor 76f 0.00865019 0.0671823 0.121219
Brugia malayi putative neuropeptide receptor 0.00865019 0.0671823 0.0921226
Echinococcus granulosus biogenic amine 5HT receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis neuropeptide receptor A26 0.00865019 0.0671823 0.121219
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.00181745 0.0049447 0.00112988
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0109616 0.088236 0.161916
Echinococcus multilocularis serotonin receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni opsin-like receptor 0.00865019 0.0671823 0.121219
Chlamydia trachomatis methionine aminopeptidase 0.018906 0.1606 0.507702
Giardia lamblia Xaa-Pro dipeptidase 0.00292631 0.015045 0.020436
Entamoeba histolytica protein kinase, putative 0.00575387 0.0408004 0.0693735
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00865019 0.0671823 0.121219
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0585599 0.521795 0.759969
Brugia malayi Tachykinin-like peptides receptor 99D 0.00865019 0.0671823 0.0921226
Toxoplasma gondii hypothetical protein 0.00181745 0.0049447 0.00112988
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.018906 0.1606 0.646597
Mycobacterium ulcerans methionine aminopeptidase 0.018906 0.1606 0.646597
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00865019 0.0671823 0.121219
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0368879 0.324392 0.469974
Trypanosoma brucei methionine aminopeptidase, putative 0.018906 0.1606 0.52968
Trichomonas vaginalis CMGC family protein kinase 0.00439274 0.0284024 0.0470142
Onchocerca volvulus Dipeptidase C homolog 0.00292631 0.015045 0.0106195
Schistosoma mansoni neuropeptide receptor 0.00865019 0.0671823 0.121219
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0109616 0.088236 0.161152
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Loa Loa (eye worm) hypothetical protein 0.00204943 0.00705775 0.00499641
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0109616 0.088236 0.161916
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.00181745 0.0049447 0.00091181
Toxoplasma gondii methionine aminopeptidase 0.018906 0.1606 0.373978
Echinococcus granulosus lipoxygenase domain containing protein 0.00204943 0.00705775 0.00499641
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.00218767 0.00831696 0.0113066
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis xaa Pro dipeptidase 0.00292631 0.015045 0.020436
Schistosoma mansoni lipoxygenase 0.0115927 0.0939847 0.173029
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.05122
Echinococcus granulosus 7TM GPCR rhodopsin 0.00865019 0.0671823 0.121219
Trypanosoma cruzi protein farnesyltransferase, putative 0.00411321 0.0258561 0.0701122
Echinococcus granulosus alpha 1A adrenergic receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni polycystin 1-related 0.00204943 0.00705775 0.00499641
Echinococcus granulosus neuropeptide receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.018906 0.1606 0.301798
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0344009 0.301738 0.995094
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.00181745 0.0049447 0.00091181
Brugia malayi latrophilin 2 splice variant baaae 0.0202188 0.172558 0.246923
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.00292631 0.015045 0.019542
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis orexin receptor type 2 0.00865019 0.0671823 0.121219
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Brugia malayi neuropeptide F receptor 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0109616 0.088236 0.161152
Echinococcus granulosus neuropeptides capa receptor 0.00865019 0.0671823 0.121219
Trypanosoma cruzi cdc2-related kinase 3 0.00439274 0.0284024 0.0786492
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0344009 0.301738 0.574623
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00865019 0.0671823 0.121219
Echinococcus granulosus o acyltransferase membrane bound domain 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) neuropeptide F receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus neuropeptides capa receptor 0.00865019 0.0671823 0.121219
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.27926
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Trypanosoma brucei lanosterol synthase 0.00411321 0.0258561 0.0852771
Brugia malayi G-protein coupled receptor 0.00865019 0.0671823 0.0921226
Giardia lamblia Telomerase catalytic subunit 0.0345615 0.303201 0.577451
Giardia lamblia Rab geranylgeranyltransferase 0.0109616 0.088236 0.161916
Schistosoma mansoni neuropeptide receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.00935842 0.0736333 0.133689
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.00292631 0.015045 0.020436
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.018906 0.1606 0.301161
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.018906 0.1606 0.301798
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0585599 0.521795 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0475983 0.42195 0.807148
Brugia malayi serine/threonine-protein kinase 6 0.00575387 0.0408004 0.0533665
Schistosoma mansoni histamine h1 receptor 0.00865019 0.0671823 0.121219
Plasmodium vivax methionine aminopeptidase 1a, putative 0.018906 0.1606 0.301161
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0701122
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0420962
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0368879 0.324392 0.618716
Onchocerca volvulus Chorion peroxidase homolog 0.00546514 0.0381705 0.0338489
Echinococcus multilocularis neuropeptide FF receptor 2 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.00181745 0.0049447 0.00091181
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0109616 0.088236 0.161152
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus fmrfamide receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus multilocularis g protein coupled receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis RUN 0.00204943 0.00705775 0.00499641
Brugia malayi neuropeptide F receptor 0.00865019 0.0671823 0.0921226
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.018906 0.1606 0.52968
Brugia malayi hypothetical protein 0.00546514 0.0381705 0.0495031
Loa Loa (eye worm) hhat protein 0.00181745 0.0049447 0.00091181
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Toxoplasma gondii methionine aminopeptidase 2, putative 0.00851103 0.0659147 0.147174
Echinococcus granulosus G protein coupled receptor 139 0.00865019 0.0671823 0.121219
Schistosoma mansoni biogenic amine receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis Polycystic kidney disease protein 0.00204943 0.00705775 0.00499641
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.11106 1 1
Giardia lamblia Rab geranylgeranyltransferase 0.00411321 0.0258561 0.0413342
Loa Loa (eye worm) hypothetical protein 0.00411321 0.0258561 0.0413342
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.00292631 0.015045 0.0155307
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0344009 0.301738 0.574234
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Entamoeba histolytica cell division protein kinase 2, putative 0.00439274 0.0284024 0.0453857
Echinococcus granulosus dna repair protein rad51 1 0.00218767 0.00831696 0.0074305
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0585599 0.521795 1
Trichomonas vaginalis porcupine, putative 0.00181745 0.0049447 0.00170592
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis somatostatin receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00444775 0.0289034 0.0472248
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.00292631 0.015045 0.020436
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.00292631 0.015045 0.0338645
Echinococcus multilocularis ATPase, H+ transporting, lysosomal accessory 0.03498 0.307013 0.584818
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Plasmodium vivax farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0404593
Brugia malayi serine/threonine protein kinase 6 0.00575387 0.0408004 0.0533665
Loa Loa (eye worm) hypothetical protein 0.0106283 0.0852003 0.156048
Plasmodium vivax methionine aminopeptidase 1c, putative 0.00292631 0.015045 0.019542
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00865019 0.0671823 0.121219
Leishmania major RAD51/dmc1 protein 0.00218767 0.00831696 0.0113066
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0420962
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.00133595 0.000558899 0.00184333
Brugia malayi Serotonin receptor 0.00865019 0.0671823 0.0921226
Toxoplasma gondii transcriptional elongation factor FACT140 0.00292631 0.015045 0.0253236
Loa Loa (eye worm) hypothetical protein 0.00181745 0.0049447 0.00091181
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Schistosoma mansoni biogenic amine receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00439274 0.0284024 0.0462562
Onchocerca volvulus 0.00204943 0.00705775 0.00259637
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.00218767 0.00831696 0.0113066
Plasmodium falciparum geranylgeranyltransferase, putative 0.00411321 0.0258561 0.0404593
Toxoplasma gondii creatinase domain-containing protein 0.00292631 0.015045 0.0253236
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.00439274 0.0284024 0.0786492
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0420962
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.00411321 0.0258561 0.0480262
Trypanosoma cruzi hypothetical protein, conserved 0.00411321 0.0258561 0.0701122
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus multilocularis cyclin dependent kinase 0.00439274 0.0284024 0.0462562
Echinococcus multilocularis neuropeptide receptor 0.00865019 0.0671823 0.121219
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.00439274 0.0284024 0.057319
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00172403 0.0040938 0.0000624165
Schistosoma mansoni hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis xaa Pro dipeptidase 0.00292631 0.015045 0.020436
Schistosoma mansoni opsin-like receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.00292631 0.015045 0.0106195
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.00181745 0.0049447 0.00091181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0030107 0.0158137 0.0166599
Brugia malayi cell division control protein 2 homolog 0.00439274 0.0284024 0.0351532
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.00181745 0.0049447 0.00091181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0030107 0.0158137 0.0226993
Loa Loa (eye worm) hypothetical protein 0.0202188 0.172558 0.324912
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.018906 0.1606 0.646597
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0109616 0.088236 0.161916
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.018906 0.1606 0.521883
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0109616 0.088236 0.27926
Onchocerca volvulus 0.00546514 0.0381705 0.0338489
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00865019 0.0671823 0.121219
Entamoeba histolytica aminopeptidase, putative 0.00292631 0.015045 0.019542
Onchocerca volvulus Peroxidasin homolog 0.00546514 0.0381705 0.0338489
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.00851103 0.0659147 0.204421
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0345615 0.303201 1
Plasmodium vivax geranylgeranyltransferase, putative 0.00411321 0.0258561 0.0404593
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0344009 0.301738 0.712053
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00865019 0.0671823 0.0921226
Trichomonas vaginalis PIKK family atypical protein kinase 0.00178184 0.00462038 0.00107951
Trichomonas vaginalis transmembrane protein nessy, putative 0.00181745 0.0049447 0.00170592
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00851103 0.0659147 0.119469
Loa Loa (eye worm) DNA-binding protein 0.00292631 0.015045 0.020436
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.00292631 0.015045 0.0496205
Echinococcus granulosus methionyl aminopeptidase 2 0.00851103 0.0659147 0.118769
Brugia malayi metallopeptidase family M24 containing protein 0.00292631 0.015045 0.0155307
Loa Loa (eye worm) neuropeptide F receptor 0.00865019 0.0671823 0.121219
Trypanosoma cruzi cdc2-related kinase 1 0.00439274 0.0284024 0.0786492
Brugia malayi Dopamine receptor protein 2 0.00865019 0.0671823 0.0921226
Echinococcus granulosus somatostatin receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis dro:myosuppressin receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0585599 0.521795 1
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Treponema pallidum methionine aminopeptidase (map) 0.018906 0.1606 0.524456
Trypanosoma cruzi Metallopeptidase family M24, putative 0.00292631 0.015045 0.0338645
Trypanosoma brucei methionine aminopeptidase 2, putative 0.00851103 0.0659147 0.217396
Onchocerca volvulus 0.00546514 0.0381705 0.0338489
Schistosoma mansoni growth hormone secretagogue receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni peptidase 0.00292631 0.015045 0.020436
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0344009 0.301738 0.574623
Brugia malayi Telomerase reverse transcriptase 0.076498 0.685189 1
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0109616 0.088236 0.27926
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.00411321 0.0258561 0.0420962
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115927 0.0939847 0.173029
Brugia malayi Guanylate kinase family protein 0.00293558 0.0151294 0.0156548
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) rad51 0.00218767 0.00831696 0.0074305
Schistosoma mansoni neuropeptide F-like receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) MBOAT family protein 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0368879 0.324392 0.618413
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0109616 0.088236 0.161916
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus Dual oxidase homolog 0.00546514 0.0381705 0.0338489
Brugia malayi hypothetical protein 0.00204943 0.00705775 0.00379711
Trypanosoma cruzi aurora B kinase, putative 0.00575387 0.0408004 0.120218
Plasmodium falciparum protein kinase 5 0.00439274 0.0284024 0.0453857
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0585599 0.521795 1
Toxoplasma gondii meiotic recombination protein DMC1 family protein 0.00218767 0.00831696 0.00920762
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0344009 0.301738 0.574623
Brugia malayi hypothetical protein 0.03498 0.307013 0.444444
Trichomonas vaginalis conserved hypothetical protein 0.00181745 0.0049447 0.00170592
Trichomonas vaginalis PIKK family atypical protein kinase 0.00199531 0.00656477 0.00483507
Trypanosoma brucei target of rapamycin kinase 3, putative 0.00243765 0.0105939 0.0349403
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) latrophilin receptor protein 2 0.00935842 0.0736333 0.133689
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.00411321 0.0258561 0.0413342
Loa Loa (eye worm) AUR protein kinase 0.00575387 0.0408004 0.0702221
Brugia malayi Methionine aminopeptidase protein type I 0.018906 0.1606 0.229357
Schistosoma mansoni serine/threonine protein kinase 0.00575387 0.0408004 0.0702221
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.018906 0.1606 0.646597
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Echinococcus granulosus g protein coupled receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis conserved hypothetical protein 0.00181745 0.0049447 0.00170592
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trypanosoma cruzi target of rapamycin kinase 3 0.00243765 0.0105939 0.0189408
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.018906 0.1606 0.301798
Brugia malayi larval opioid receptor 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis G protein coupled receptor 139 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) G-protein coupled receptor 0.00865019 0.0671823 0.121219
Leishmania major hypothetical protein, conserved 0.00292631 0.015045 0.0338645
Loa Loa (eye worm) AUR protein kinase 0.00575387 0.0408004 0.0702221
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0030107 0.0158137 0.0364416
Trichomonas vaginalis PIKK family atypical protein kinase 0.00178184 0.00462038 0.00107951
Echinococcus granulosus tachykinin peptides receptor 99D 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trypanosoma brucei glycerol uptake protein, putative 0.00181745 0.0049447 0.0163083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0295772 0.257801 0.372149
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0344009 0.301738 0.995094
Echinococcus granulosus aurora kinase A 0.00575387 0.0408004 0.0702221
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Brugia malayi Latrophilin receptor protein 2 0.00935842 0.0736333 0.101599
Trichomonas vaginalis CMGC family protein kinase 0.00439274 0.0284024 0.0470142
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.00292631 0.015045 0.020436
Trichomonas vaginalis AGC family protein kinase 0.00575387 0.0408004 0.0709611
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00865019 0.0671823 0.0921226
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.00411321 0.0258561 0.0314127
Echinococcus multilocularis Proliferation associated protein 2G4 0.00292631 0.015045 0.020436
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.00181745 0.0049447 0.00091181
Echinococcus granulosus sex peptide receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis dna repair protein rad51 1 0.00218767 0.00831696 0.0074305
Entamoeba histolytica protein kinase , putative 0.00575387 0.0408004 0.0693735
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.00575387 0.0408004 0.0693735
Schistosoma mansoni hypothetical protein 0.00935842 0.0736333 0.133689
Brugia malayi G protein-coupled receptor 0.00865019 0.0671823 0.0921226
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0585599 0.521795 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0030107 0.0158137 0.0226993
Giardia lamblia Methionine aminopeptidase 0.00851103 0.0659147 0.118769
Giardia lamblia Kinase, CMGC CDK 0.00439274 0.0284024 0.0462562
Entamoeba histolytica protein kinase domain containing protein 0.00575387 0.0408004 0.0693735
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.00444775 0.0289034 0.0472248
Plasmodium falciparum protein farnesyltransferase subunit beta 0.00411321 0.0258561 0.0404593
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.00181745 0.0049447 0.00091181
Brugia malayi RE15519p 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis g protein coupled receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni cell polarity protein 0.00269421 0.0129309 0.0163493
Echinococcus multilocularis allatostatin A receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Trypanosoma cruzi aminopeptidase P1, putative 0.00292631 0.015045 0.0338645
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) TYRA-2 protein 0.00865019 0.0671823 0.121219
Echinococcus granulosus g protein coupled receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni loxhd1 0.00204943 0.00705775 0.00499641
Echinococcus granulosus 7tm_1 domain containing protein 0.00865019 0.0671823 0.121219
Brugia malayi G-protein coupled receptor 0.00865019 0.0671823 0.0921226
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.00411321 0.0258561 0.0404593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0030107 0.0158137 0.0364416
Schistosoma mansoni biogenic amine receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.00181745 0.0049447 0.00091181
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0344009 0.301738 0.436695
Loa Loa (eye worm) MBOAT family protein 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0368879 0.324392 0.618413
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0420962
Echinococcus multilocularis neuropeptide Y receptor 0.00865019 0.0671823 0.121219
Brugia malayi metallopeptidase family M24 containing protein 0.00292631 0.015045 0.0155307
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni protein kinase 0.00575387 0.0408004 0.0702221
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0030107 0.0158137 0.0210292
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.00935842 0.0736333 0.101599
Leishmania major farnesyltransferase beta subunit 0.00411321 0.0258561 0.0701122
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.00439274 0.0284024 0.0462562
Echinococcus multilocularis G-protein coupled receptor, putative 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00292631 0.015045 0.020436
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0109616 0.088236 0.291014
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00865019 0.0671823 0.121219
Leishmania major methionine aminopeptidase 2, putative 0.00851103 0.0659147 0.204421
Echinococcus multilocularis g protein coupled receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.00292631 0.015045 0.020436
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Leishmania major geranylgeranyltransferase, putative 0.00411321 0.0258561 0.0701122
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Loa Loa (eye worm) guanylate kinase 0.00246572 0.0108497 0.0123263
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi Doublecortin family protein 0.00204943 0.00705775 0.00379711
Trichomonas vaginalis meiosis-specific recA homolog Dmc1 0.00218767 0.00831696 0.00821943
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis methionyl aminopeptidase 2 0.00851103 0.0659147 0.118769
Plasmodium falciparum telomerase reverse transcriptase 0.0345615 0.303201 0.577066
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.00411321 0.0258561 0.0413342
Loa Loa (eye worm) hypothetical protein 0.00411321 0.0258561 0.0413342
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00865019 0.0671823 0.121219
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0852771
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0109616 0.088236 0.291014
Plasmodium vivax methionine aminopeptidase 2, putative 0.00851103 0.0659147 0.117964
Echinococcus granulosus tm gpcr rhodopsin 0.00865019 0.0671823 0.121219
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.00851103 0.0659147 0.0617177
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.00292631 0.015045 0.020436
Onchocerca volvulus 0.00292631 0.015045 0.0106195
Loa Loa (eye worm) hypothetical protein 0.00181745 0.0049447 0.00091181
Trypanosoma brucei hypothetical protein, conserved 0.0109616 0.088236 0.291014
Schistosoma mansoni lipoxygenase 0.00790373 0.0603829 0.108076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus multilocularis lipoxygenase domain containing protein 0.00204943 0.00705775 0.00499641
Echinococcus granulosus dro:myosuppressin receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis sterol O acyltransferase 1 0.0124457 0.101755 0.188049
Trichomonas vaginalis PIKK family atypical protein kinase 0.00178184 0.00462038 0.00107951
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.00181745 0.0049447 0.00091181
Trypanosoma brucei Metallopeptidase family M24, putative 0.00292631 0.015045 0.0496205
Echinococcus granulosus ATPase H transporting lysosomal accessory 0.03498 0.307013 0.584818
Brugia malayi metallopeptidase family M24 containing protein 0.00292631 0.015045 0.0155307
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0030107 0.0158137 0.0521556
Echinococcus granulosus g protein coupled receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus protein farnesyltransferase subunit beta 0.00411321 0.0258561 0.0413342
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Toxoplasma gondii aurora kinase 0.00575387 0.0408004 0.0870167
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Brugia malayi Serotonin receptor 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) G-protein coupled receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00204943 0.00705775 0.00259637
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.00292631 0.015045 0.019542
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00865019 0.0671823 0.0921226
Echinococcus granulosus Proliferation associated protein 2G4 0.00292631 0.015045 0.020436
Trichomonas vaginalis PIKK family atypical protein kinase 0.00172403 0.0040938 0.0000624165
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.00181745 0.0049447 0.00091181
Echinococcus multilocularis FACT complex subunit SPT16 0.00292631 0.015045 0.020436
Echinococcus granulosus microsomal glutathione S transferase 3 0.0116319 0.0943417 0.173719
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Echinococcus granulosus FACT complex subunit SPT16 0.00292631 0.015045 0.020436
Loa Loa (eye worm) initiation factor 2-associated protein 0.00851103 0.0659147 0.118769
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.018906 0.1606 0.646597
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00865019 0.0671823 0.121219
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.00243765 0.0105939 0.0189408
Schistosoma mansoni opsin-like receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni biogenic amine (5HT) receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni alpha-1 adrenergic receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Loa Loa (eye worm) STAT protein 0.0312888 0.273391 0.519827
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00865019 0.0671823 0.121219
Giardia lamblia Prenyltransferase 0.00411321 0.0258561 0.0413342
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Onchocerca volvulus Peroxidase homolog 0.00546514 0.0381705 0.0338489
Trypanosoma cruzi Metallopeptidase family M24, putative 0.00292631 0.015045 0.0338645
Echinococcus granulosus o acyltransferase membrane bound domain 0.00181745 0.0049447 0.00091181
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.0109616 0.088236 0.0841394
Brugia malayi STAT protein, DNA binding domain containing protein 0.0312888 0.273391 0.395052
Plasmodium vivax telomerase reverse transcriptase, putative 0.0345615 0.303201 0.577066
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.018906 0.1606 0.52968
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0496205
Plasmodium falciparum aminopeptidase P 0.00292631 0.015045 0.019542
Schistosoma mansoni microsomal glutathione s-transferase 0.0116319 0.0943417 0.173719
Leishmania major telomerase reverse transcriptase, putative 0.0345615 0.303201 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0404593
Trypanosoma cruzi hypothetical protein, conserved 0.0109616 0.088236 0.27926
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00865019 0.0671823 0.121219
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0109616 0.088236 0.161916
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00865019 0.0671823 0.121219
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00851103 0.0659147 0.119469
Chlamydia trachomatis transcriptional repressor NrdR 0.00676103 0.0499744 0.121835
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.00411321 0.0258561 0.0420962
Trichomonas vaginalis AGC family protein kinase 0.00575387 0.0408004 0.0709611
Brugia malayi ORL1-like opioid receptor 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus biogenic amine 5HT receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00186815 0.00540653 0.00259794
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00865019 0.0671823 0.121219
Mycobacterium leprae conserved hypothetical protein 0.00676103 0.0499744 0.155167
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.00575387 0.0408004 0.0693735
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Trichomonas vaginalis AGC family protein kinase 0.00444775 0.0289034 0.0479821
Plasmodium vivax multidomain scavenger receptor, putative 0.00204943 0.00705775 0.00408833
Echinococcus multilocularis fmrfamide receptor 0.00865019 0.0671823 0.121219
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00865019 0.0671823 0.0921226
Echinococcus multilocularis methionine aminopeptidase, type I 0.00292631 0.015045 0.020436
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.00411321 0.0258561 0.0420962
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Loa Loa (eye worm) animal heme peroxidase 0.00546514 0.0381705 0.0651384
Mycobacterium ulcerans methionine aminopeptidase MapB 0.018906 0.1606 0.646597
Loa Loa (eye worm) hypothetical protein 0.00935842 0.0736333 0.133689
Echinococcus granulosus allatostatin A receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Brugia malayi Dopamine receptor 0.00865019 0.0671823 0.0921226
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0368879 0.324392 0.618065
Trichomonas vaginalis AGC family protein kinase 0.00575387 0.0408004 0.0709611
Schistosoma mansoni hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis neuropeptides capa receptor 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Schistosoma mansoni myosin xvIII 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) phosphatidylinositol 3 0.0030107 0.0158137 0.0219218
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0496205
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Echinococcus granulosus RUN 0.00204943 0.00705775 0.00499641
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.018906 0.1606 0.373978
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.00181745 0.0049447 0.00091181
Entamoeba histolytica cell division protein kinase 2, putative 0.00439274 0.0284024 0.0453857
Echinococcus granulosus hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00439274 0.0284024 0.0462562
Giardia lamblia GTOR 0.0030107 0.0158137 0.0219218
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00851103 0.0659147 0.119469
Echinococcus multilocularis lipoxygenase domain containing protein 0.00204943 0.00705775 0.00499641
Loa Loa (eye worm) hhat protein 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) blistered cuticle protein 3 0.00546514 0.0381705 0.0651384
Echinococcus multilocularis peroxidasin 0.00546514 0.0381705 0.0651384
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00865019 0.0671823 0.062991
Onchocerca volvulus Peroxidasin homolog 0.00546514 0.0381705 0.0338489
Trypanosoma cruzi DNA repair protein RAD51, putative 0.00218767 0.00831696 0.0113066
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.00411321 0.0258561 0.0413342
Schistosoma mansoni amine GPCR 0.00865019 0.0671823 0.121219
Plasmodium vivax proliferation-associated protein 2g4, putative 0.00292631 0.015045 0.019542
Echinococcus granulosus neuropeptide FF receptor 2 0.00865019 0.0671823 0.121219
Echinococcus granulosus serotonin receptor 0.00865019 0.0671823 0.121219
Entamoeba histolytica methionine aminopeptidase, putative 0.00851103 0.0659147 0.117964
Plasmodium vivax serine/threonine protein kinase 6, putative 0.00575387 0.0408004 0.0693735
Brugia malayi phosphoinositide-dependent protein kinase I 0.00444775 0.0289034 0.0358893
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0368879 0.324392 0.618413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Brugia malayi MBOAT family protein 0.00181745 0.0049447 0.000692947
Schistosoma mansoni zinc finger protein 0.00181745 0.0049447 0.00091181
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Loa Loa (eye worm) hypothetical protein 0.0124457 0.101755 0.188049
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Echinococcus granulosus rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Brugia malayi Blistered cuticle protein 3 0.00546514 0.0381705 0.0495031
Echinococcus granulosus serine:threonine protein kinase 12 B 0.00575387 0.0408004 0.0702221
Echinococcus granulosus cyclin dependent kinase 5 0.00439274 0.0284024 0.0462562
Schistosoma mansoni neuropeptide receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus xaa Pro dipeptidase 0.00292631 0.015045 0.020436
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Brugia malayi putative neuropeptide receptor NPR1 0.00865019 0.0671823 0.0921226
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115927 0.0939847 0.173029
Echinococcus multilocularis fmrfamide receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus GPCR family 2 0.00935842 0.0736333 0.133689
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.00444775 0.0289034 0.0472248
Trichomonas vaginalis PIKK family atypical protein kinase 0.00192951 0.00596543 0.00367746
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0030107 0.0158137 0.0521556
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00865019 0.0671823 0.121219
Onchocerca volvulus 0.00865019 0.0671823 0.062991
Echinococcus multilocularis neuropeptide receptor 0.00865019 0.0671823 0.121219
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Onchocerca volvulus 0.00546514 0.0381705 0.0338489
Echinococcus multilocularis xaa pro aminopeptidase 0.00292631 0.015045 0.020436
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.00935842 0.0736333 0.133689
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.00997637 0.079262 0.285271
Schistosoma mansoni serine/threonine protein kinase 0.00439274 0.0284024 0.0462562
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0109616 0.088236 0.161916
Echinococcus granulosus peptide allatostatin:somatostatin 0.00865019 0.0671823 0.121219
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0344009 0.301738 0.574623
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.00411321 0.0258561 0.0314127
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus neuropeptide receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis g-protein coupled receptor 0.00865019 0.0671823 0.121219
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0030107 0.0158137 0.0364416
Trypanosoma cruzi lanosterol synthase, putative 0.00411321 0.0258561 0.0701122
Echinococcus granulosus xaa pro aminopeptidase 0.00292631 0.015045 0.020436
Echinococcus granulosus lipoxygenase domain containing protein 0.00204943 0.00705775 0.00499641
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis aurora kinase A 0.00575387 0.0408004 0.0702221
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00865019 0.0671823 0.121219
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.00292631 0.015045 0.0212146
Trypanosoma cruzi DNA repair protein RAD51, putative 0.00218767 0.00831696 0.0113066
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0344009 0.301738 0.574234
Plasmodium vivax protein kinase Crk2 0.00439274 0.0284024 0.0453857
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.018906 0.1606 0.301161
Echinococcus granulosus methionine aminopeptidase type I 0.00292631 0.015045 0.020436
Schistosoma mansoni hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni serine/threonine protein kinase 0.00444775 0.0289034 0.0472248
Schistosoma mansoni hypothetical protein 0.00935842 0.0736333 0.133689
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni peroxidasin 0.00546514 0.0381705 0.0651384
Brugia malayi AKH receptor 0.00865019 0.0671823 0.0921226
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0030107 0.0158137 0.0219218
Trichomonas vaginalis AGC family protein kinase 0.00444775 0.0289034 0.0479821
Echinococcus granulosus lysophospholipid acyltransferase 7 0.00181745 0.0049447 0.00091181
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Toxoplasma gondii hypothetical protein 0.0109616 0.088236 0.200641
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.00292631 0.015045 0.0338645
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00865019 0.0671823 0.121219
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.00292631 0.015045 0.0338645
Echinococcus granulosus orexin receptor type 2 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) melatonin receptor type 1A 0.00865019 0.0671823 0.121219
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0345615 0.303201 1
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0344009 0.301738 0.995174
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.00292631 0.015045 0.020436
Loa Loa (eye worm) doublecortin family protein 0.00204943 0.00705775 0.00499641
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00865019 0.0671823 0.121219
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0585599 0.521795 1
Trypanosoma brucei telomerase reverse transcriptase 0.0345615 0.303201 1
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0276399 0.240154 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.00676103 0.0499744 0.155167
Schistosoma mansoni sterol O-acyltransferase 1 0.0124457 0.101755 0.188049
Schistosoma mansoni serine/threonine protein kinase 0.00439274 0.0284024 0.0462562
Brugia malayi Animal haem peroxidase family protein 0.00546514 0.0381705 0.0495031
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.00444775 0.0289034 0.0472248
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Loa Loa (eye worm) diacylglycerol acyltransferase 0.00181745 0.0049447 0.00091181
Trypanosoma cruzi protein farnesyltransferase, putative 0.00411321 0.0258561 0.0701122
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.00411321 0.0258561 0.0413342
Echinococcus multilocularis neuropeptide Y receptor 0.00865019 0.0671823 0.121219
Brugia malayi hypothetical protein 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.00181745 0.0049447 0.00091181
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0030107 0.0158137 0.0219218
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.00851103 0.0659147 0.118769
Loa Loa (eye worm) methionine aminopeptidase type I 0.018906 0.1606 0.301798
Loa Loa (eye worm) animal heme peroxidase 0.00546514 0.0381705 0.0651384
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus sterol O acyltransferase 1 0.0124457 0.101755 0.188049
Echinococcus multilocularis neuropeptide s receptor 0.00865019 0.0671823 0.121219
Echinococcus multilocularis disks large 3 0.00269421 0.0129309 0.0163493
Loa Loa (eye worm) animal heme peroxidase 0.00546514 0.0381705 0.0651384
Onchocerca volvulus 0.00181745 0.0049447 0.000473819
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Trypanosoma brucei aurora B kinase 0.00575387 0.0408004 0.134565
Brugia malayi initiation factor 2-associated protein. 0.00851103 0.0659147 0.0902604
Schistosoma mansoni neuropeptide receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Schistosoma mansoni hypothetical protein 0.00204943 0.00705775 0.00499641
Brugia malayi Protein kinase domain containing protein 0.00444775 0.0289034 0.0358893
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0030107 0.0158137 0.0210292
Brugia malayi hypothetical protein 0.00204943 0.00705775 0.00379711
Schistosoma mansoni hypothetical protein 0.0202188 0.172558 0.324912
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0585599 0.521795 1
Loa Loa (eye worm) MBOAT family protein 0.00181745 0.0049447 0.00091181
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00865019 0.0671823 0.121219
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.00845661 0.065419 0.202759
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00865019 0.0671823 0.121219
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0585599 0.521795 1
Loa Loa (eye worm) hypothetical protein 0.00292631 0.015045 0.020436
Loa Loa (eye worm) hypothetical protein 0.00426948 0.0272796 0.0440859
Schistosoma mansoni hypothetical protein 0.00865019 0.0671823 0.121219
Toxoplasma gondii methionine aminopeptidase 0.018906 0.1606 0.373978
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.00411321 0.0258561 0.0404593
Echinococcus multilocularis rhodopsin orphan GPCR 0.00865019 0.0671823 0.121219
Giardia lamblia Kinase, CMGC CDK 0.00439274 0.0284024 0.0462562
Plasmodium falciparum methionine aminopeptidase 2 0.00851103 0.0659147 0.117964
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.00181745 0.0049447 0.00091181
Echinococcus granulosus cyclin dependent kinase 0.00439274 0.0284024 0.0462562
Echinococcus granulosus neuropeptide Y receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Trypanosoma cruzi aminopeptidase P, putative 0.00292631 0.015045 0.0338645
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.00292631 0.015045 0.0338645
Trichomonas vaginalis PIKK family atypical protein kinase 0.00249901 0.0111528 0.0136969
Trichomonas vaginalis PIKK family atypical protein kinase 0.00172403 0.0040938 0.0000624165
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.018906 0.1606 0.301798
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00865019 0.0671823 0.121219
Echinococcus granulosus tm gpcr rhodopsin 0.00865019 0.0671823 0.121219
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.00292631 0.015045 0.020436
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.00292631 0.015045 0.0253236
Entamoeba histolytica peptidase, putative 0.00292631 0.015045 0.019542
Schistosoma mansoni hypothetical protein 0.00935842 0.0736333 0.133689
Echinococcus granulosus disks large 3 0.00269421 0.0129309 0.0163493
Plasmodium falciparum serine/threonine protein kinase, putative 0.00575387 0.0408004 0.0693735
Trypanosoma cruzi cdc2-related kinase 1 0.00439274 0.0284024 0.0786492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00865019 0.0671823 0.121219
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0276399 0.240154 1
Loa Loa (eye worm) hypothetical protein 0.00546514 0.0381705 0.0651384
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.00411321 0.0258561 0.05122
Plasmodium falciparum FACT complex subunit SPT16, putative 0.00292631 0.015045 0.019542
Entamoeba histolytica hypothetical protein, conserved 0.00292631 0.015045 0.019542
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0109616 0.088236 0.123051
Plasmodium vivax peptidase, putative 0.00292631 0.015045 0.019542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024412 0.0106262 0.0126798
Trichomonas vaginalis conserved hypothetical protein 0.00181745 0.0049447 0.00170592
Brugia malayi Dopamine receptor protein 1 0.00865019 0.0671823 0.0921226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0295772 0.257801 0.48969
Brugia malayi Calcitonin receptor-like protein seb-1 0.0295772 0.257801 0.372149
Giardia lamblia Xaa-Pro dipeptidase 0.00292631 0.015045 0.020436
Echinococcus granulosus g-protein coupled receptor 0.00865019 0.0671823 0.121219
Loa Loa (eye worm) hypothetical protein 0.00865019 0.0671823 0.121219
Brugia malayi diacylglycerol acyltransferase 0.00181745 0.0049447 0.000692947
Echinococcus granulosus peroxidasin 0.00546514 0.0381705 0.0651384
Schistosoma mansoni hypothetical protein 0.00935842 0.0736333 0.133689
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.00292631 0.015045 0.019542
Trichomonas vaginalis PIKK family atypical protein kinase 0.00229353 0.00928121 0.0100819
Toxoplasma gondii MAPEG family protein 0.0116319 0.0943417 0.215266

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 20 nM Antimalarial activity against Plasmodium falciparum. ChEMBL. 11741486
EC50 (functional) > 20 nM Antimalarial activity against Plasmodium falciparum. ChEMBL. 11741486
IC50 (functional) = 5.4 uM Cytotoxicity against KB cells. ChEMBL. 11741486
IC50 (functional) = 9.6 uM Cytotoxicity against BC cells. ChEMBL. 11741486
IC50 (functional) > 42 uM Cytotoxicity against vero cells. ChEMBL. 11741486
TI (ADMET) > 2.1 Therapeutic index (TI) determined as IC50 of vero cells to that of EC50 ChEMBL. 11741486

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 11741486

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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