Detailed information for compound 411707

Basic information

Technical information
  • TDR Targets ID: 411707
  • Name: 2-[(4-chlorophenyl)methyl]-3-hydroxy-8-propan -2-ylquinoline-4-carboxylic acid
  • MW: 355.815 | Formula: C20H18ClNO3
  • H donors: 2 H acceptors: 4 LogP: 5.62 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cc1nc2c(cccc2c(c1O)C(=O)O)C(C)C
  • InChi: 1S/C20H18ClNO3/c1-11(2)14-4-3-5-15-17(20(24)25)19(23)16(22-18(14)15)10-12-6-8-13(21)9-7-12/h3-9,11,23H,10H2,1-2H3,(H,24,25)
  • InChiKey: GWTUJJVNZIYLNO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-chlorophenyl)methyl]-3-hydroxy-8-isopropyl-quinoline-4-carboxylic acid
  • 2-[(4-chlorophenyl)methyl]-3-hydroxy-8-isopropyl-4-quinolinecarboxylic acid
  • 2-[(4-chlorophenyl)methyl]-3-hydroxy-8-propan-2-yl-quinoline-4-carboxylic acid
  • 2-(4-chlorobenzyl)-3-hydroxy-8-isopropyl-cinchoninic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0509 0.0509
Toxoplasma gondii proteasome subunit alpha1, putative 0.0035 0.0509 0.0266
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0035 0.0509 0.0509
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0035 0.0509 0.0509
Echinococcus granulosus Proteasome subunit alpha type 7 0.0035 0.0509 0.0509
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0035 0.0509 0.0266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0035 0.0509 0.0266
Leishmania major proteasome alpha 1 subunit, putative 0.0035 0.0509 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0035 0.0509 0.0509
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0467 1 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.025 0.025
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.025 0.025
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0079 0.0079
Onchocerca volvulus 0.0023 0.025 0.3966
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0509 0.0266
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Echinococcus granulosus proteasome subunit alpha type 6 0.0035 0.0509 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0035 0.0509 0.0433
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0035 0.0509 0.0509
Onchocerca volvulus 0.0023 0.025 0.3966
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0509 0.0509
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0035 0.0509 0.0509
Brugia malayi Proteasome subunit alpha type 1 0.0035 0.0509 0.0509
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0509 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0035 0.0509 0.0509
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0079 0.0079
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0509 0.0509
Echinococcus granulosus proteasome subunit beta type 6 0.0035 0.0509 0.0509
Brugia malayi proteasome subunit beta type 3 0.0035 0.0509 0.0509
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0035 0.0509 0.0509
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0035 0.0509 0.0509
Loa Loa (eye worm) ctsf protein 0.0023 0.025 0.0172
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0035 0.0509 0.0509
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0035 0.0509 0.0266
Plasmodium vivax vivapain-2 0.0023 0.025 0.025
Echinococcus granulosus proteasome subunit alpha type 2 0.0035 0.0509 0.0509
Leishmania major proteasome beta 7 subunit, putative 0.0035 0.0509 0.0266
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0035 0.0509 0.0509
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0035 0.0509 0.0433
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0035 0.0509 0.0509
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0035 0.0509 0.0266
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0035 0.0509 0.0509
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0035 0.0509 0.0509
Onchocerca volvulus 0.0023 0.025 0.3966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0035 0.0509 0.0509
Leishmania major proteasome alpha 7 subunit, putative 0.0035 0.0509 0.0266
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0035 0.0509 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Brugia malayi Cathepsin L-like precursor 0.0016 0.0079 0.0079
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.025 0.025
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0509 0.0509
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0467 1 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0035 0.0509 0.0509
Brugia malayi proteasome subunit alpha type 6 0.0035 0.0509 0.0509
Plasmodium vivax proteasome subunit beta type-6, putative 0.0035 0.0509 0.0509
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0035 0.0509 0.0509
Brugia malayi proteasome subunit alpha type 4 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0035 0.0509 0.0509
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.025 0.025
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0035 0.0509 0.0509
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0035 0.0509 0.0509
Trypanosoma cruzi 20S proteasome subunit 0.0035 0.0509 0.0509
Brugia malayi Cathepsin L-like precursor 0.0023 0.025 0.025
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0467 1 1
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0035 0.0509 0.0509
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0035 0.0509 0.0433
Plasmodium vivax proteasome subunit beta type-7, putative 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0035 0.0509 0.0509
Echinococcus multilocularis cysteine protease 0.0023 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0023 0.025 0.0172
Brugia malayi Cathepsin L-like precursor 0.0016 0.0079 0.0079
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0509 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0035 0.0509 0.0266
Echinococcus multilocularis proteasome subunit alpha type 2 0.0035 0.0509 0.0509
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0035 0.0509 0.5
Brugia malayi proteasome subunit beta type 2 0.0035 0.0509 0.0509
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0035 0.0509 0.0509
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0467 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.025 0.025
Loa Loa (eye worm) proteasome subunit beta type 3 0.0035 0.0509 0.0433
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0035 0.0509 0.0509
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0035 0.0509 0.0509
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.025 0.025
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0035 0.0509 0.0509
Loa Loa (eye worm) proteasome subunit beta type 2 0.0035 0.0509 0.0433
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.025 0.025
Onchocerca volvulus 0.0023 0.025 0.3966
Trypanosoma brucei proteasome alpha 7 subunit 0.0035 0.0509 0.0509
Brugia malayi proteasome subunit alpha type 3 0.0035 0.0509 0.0509
Echinococcus multilocularis proteasome subunit beta type 7 0.0035 0.0509 0.0509
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0035 0.0509 0.0509
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.025 0.0172
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0035 0.0509 0.0509
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0035 0.0509 0.0509
Echinococcus multilocularis cysteine protease 0.0023 0.025 0.025
Leishmania major proteasome alpha 2 subunit, putative 0.0035 0.0509 0.0266
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0035 0.0509 0.0509
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.025 0.025
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0035 0.0509 0.0509
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0035 0.0509 0.0266
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0035 0.0509 0.0509
Leishmania major proteasome alpha 7 subunit, putative 0.0035 0.0509 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Brugia malayi 20S proteasome alpha5 subunit 0.0035 0.0509 0.0509
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0509 0.0509
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0079 0.0079
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0509 0.0509
Echinococcus multilocularis proteasome subunit alpha type 6 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0035 0.0509 0.0509
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Brugia malayi Cathepsin L-like precursor 0.0023 0.025 0.025
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0035 0.0509 0.0509
Brugia malayi Cathepsin L-like cysteine proteinase 0.0016 0.0079 0.0079
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0467 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.025 0.025
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0035 0.0509 0.0509
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0035 0.0509 0.0509
Echinococcus multilocularis proteasome (prosome, macropain) 0.0467 1 1
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0035 0.0509 0.0509
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0035 0.0509 0.0509
Toxoplasma gondii proteasome subunit alpha type, putative 0.0035 0.0509 0.0266
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0035 0.0509 0.0509
Mycobacterium ulcerans proteasome PrcB 0.0467 1 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0035 0.0509 0.0509
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.025 0.0172
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0016 0.0079 0.0079
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0035 0.0509 0.0509
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.025 0.025
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0467 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0079 0.0079
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0035 0.0509 0.0509
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0035 0.0509 0.0433
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0035 0.0509 0.0509
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.025 0.025
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0035 0.0509 0.0509
Leishmania major proteasome beta-1 subunit, putative 0.0035 0.0509 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0035 0.0509 0.0509
Toxoplasma gondii peptidase, T1 family protein 0.0035 0.0509 0.0266
Onchocerca volvulus Cathepsin L homolog 0.0023 0.025 0.3966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.025 0.025
Plasmodium falciparum proteasome subunit beta type-5 0.0467 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Loa Loa (eye worm) PAS-3 protein 0.0035 0.0509 0.0433
Onchocerca volvulus Notchless protein homolog 0.0035 0.0509 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0035 0.0509 0.0433
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0035 0.0509 0.0509
Onchocerca volvulus 0.0023 0.025 0.3966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0035 0.0509 0.0266
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0509 0.0509
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.025 0.025
Brugia malayi proteasome subunit alpha type 1 0.0035 0.0509 0.0509
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0035 0.0509 0.0509
Plasmodium vivax proteasome subunit beta type-5, putative 0.0467 1 1
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0035 0.0509 0.0509
Echinococcus granulosus proteasome subunit beta t family 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0035 0.0509 0.0509
Leishmania major proteasome beta 5 subunit, putative 0.0467 1 1
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0035 0.0509 0.0509
Loa Loa (eye worm) proteasome subunit beta type 1 0.0035 0.0509 0.0433
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0509 0.0509
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0509 0.0509
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.025 0.025
Echinococcus multilocularis proteasome subunit beta type 6 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0035 0.0509 0.0509
Onchocerca volvulus Cathepsin F homolog 0.0023 0.025 0.3966
Plasmodium vivax proteasome subunit beta type-4, putative 0.0035 0.0509 0.0509
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0035 0.0509 0.0509
Brugia malayi Cathepsin L-like precursor 0.0023 0.025 0.025
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0035 0.0509 0.0509
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0035 0.0509 0.0509
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0035 0.0509 0.0509
Onchocerca volvulus Cathepsin L homolog 0.0023 0.025 0.3966
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0035 0.0509 0.0509
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0035 0.0509 0.0509
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0035 0.0509 0.0433
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.025 0.025
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0035 0.0509 0.0509
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0509 0.0266
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0035 0.0509 0.0433
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0035 0.0509 0.0509
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.025 0.025
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0509 0.0509
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0035 0.0509 0.0509
Plasmodium vivax proteasome subunit beta type-2, putative 0.0035 0.0509 0.0509
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0035 0.0509 0.0509
Echinococcus granulosus proteasome subunit beta type 7 0.0035 0.0509 0.0509
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0035 0.0509 0.0509
Echinococcus granulosus cathepsin l1 0.0016 0.0079 0.0079
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.025 0.025
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0509 0.0266
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.025 0.025
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0035 0.0509 0.0433
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0035 0.0509 0.0509
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0035 0.0509 0.0433
Loa Loa (eye worm) fibroinase 0.0023 0.025 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0467 1 1
Plasmodium vivax proteasome subunit beta type-1, putative 0.0035 0.0509 0.0509
Loa Loa (eye worm) cysteine protease 0.0023 0.025 0.0172
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0035 0.0509 0.0509
Echinococcus granulosus proteasome prosome macropain 0.0467 1 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0035 0.0509 0.0509
Brugia malayi Proteasome A-type and B-type family protein 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0035 0.0509 0.0509
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0035 0.0509 0.0509
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0035 0.0509 0.0509
Brugia malayi proteasome subunit beta type 1 0.0035 0.0509 0.0509
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0035 0.0509 0.0509
Plasmodium falciparum proteasome subunit beta type-4 0.0035 0.0509 0.0509
Brugia malayi Proteasome A-type and B-type family protein 0.0035 0.0509 0.0509
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.025 0.025
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.025 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Brugia malayi Proteasome A-type and B-type family protein 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0509 0.0266
Echinococcus granulosus subfamily T1A non peptidase ue 0.0035 0.0509 0.0509
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0035 0.0509 0.0509
Leishmania major proteasome alpha 3 subunit, putative 0.0035 0.0509 0.0266
Trypanosoma brucei proteasome beta 7 subunit 0.0035 0.0509 0.0509
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0035 0.0509 0.0509
Brugia malayi Cathepsin L-like precursor 0.0023 0.025 0.025
Brugia malayi Cathepsin L-like precursor 0.0023 0.025 0.025
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Onchocerca volvulus 0.0023 0.025 0.3966
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0035 0.0509 0.0266
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Brugia malayi cathepsin L-like precursor 0.0016 0.0079 0.0079
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0035 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0467 1 1
Trypanosoma brucei proteasome beta 6 subunit 0.0035 0.0509 0.0509
Entamoeba histolytica cysteine protease, putative 0.0023 0.025 0.025
Echinococcus granulosus Proteasome subunit alpha beta 0.0035 0.0509 0.0509
Leishmania major proteasome beta 2 subunit, putative 0.0035 0.0509 0.0266
Echinococcus granulosus cathepsin l1 0.0023 0.025 0.025
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0467 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.025 0.025
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0509 0.0509
Leishmania major proteasome beta 2 subunit, putative 0.0035 0.0509 0.0266
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0035 0.0509 0.0509
Toxoplasma gondii proteasome beta subunit 0.0035 0.0509 0.0266
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0035 0.0509 0.0509
Leishmania major proteasome alpha 1 subunit, putative 0.0035 0.0509 0.0266
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0035 0.0509 0.0509
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0509 0.0266
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0035 0.0509 0.0266
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0035 0.0509 0.0509
Leishmania major proteasome beta 3 subunit, putative 0.0035 0.0509 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.025 0.025
Plasmodium vivax vivapain-2 0.0023 0.025 0.025
Onchocerca volvulus 0.0023 0.025 0.3966
Toxoplasma gondii proteasome subunit beta type, putative 0.0467 1 1
Brugia malayi Proteasome subunit alpha type 7-1 0.0035 0.0509 0.0509
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0035 0.0509 0.0509
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0035 0.0509 0.0509
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0509 0.0509
Toxoplasma gondii heat shock protein hslv, putative 0.0035 0.0509 0.0266
Brugia malayi proteasome subunit alpha type 2 0.0035 0.0509 0.0509
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0035 0.0509 0.0509
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0035 0.0509 0.0266
Toxoplasma gondii proteasome subunit 0.0035 0.0509 0.0266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.025 0.025
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0467 1 1
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0035 0.0509 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.025 0.025
Plasmodium vivax proteasome subunit beta type-3, putative 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0035 0.0509 0.0509
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0035 0.0509 0.0509
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0035 0.0509 0.0509
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0035 0.0509 0.0509

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 225 uM Inhibition of P-Selectin by Biacore assay ChEMBL. 17201409
IC50 (binding) = 225 uM Inhibition of P-Selectin by Biacore assay ChEMBL. 17201409

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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