Detailed information for compound 412148

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.528 | Formula: C26H30N2O3
  • H donors: 2 H acceptors: 3 LogP: 3.59 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=C[C@@]1(C)CC[C@H]2[C@]3(C1(C#N)[C@H]1O[C@H]1C(C1=Nc4c([C@]31O)c(C2(C)C)ccc4)(C)C)O
  • InChi: 1S/C26H30N2O3/c1-7-23(6)12-11-16-21(2,3)14-9-8-10-15-17(14)25(29)20(28-15)22(4,5)18-19(31-18)24(23,13-27)26(16,25)30/h7-10,16,18-19,29-30H,1,11-12H2,2-6H3/t16-,18-,19+,23+,24?,25-,26+/m1/s1
  • InChiKey: JNFLCQAQLNNMTM-CCZGIPDWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0029 0.0466 0.0466
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0029 0.0466 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Echinococcus multilocularis proteasome subunit beta type 6 0.0029 0.0466 0.0466
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0029 0.0466 0.0466
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0293 0.0293
Leishmania major proteasome beta-1 subunit, putative 0.0029 0.0466 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Echinococcus multilocularis cysteine protease 0.0023 0.0293 0.0293
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0093 0.0093
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0029 0.0466 0.0466
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0029 0.0466 0.0178
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0029 0.0466 0.0376
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0029 0.0466 0.0466
Brugia malayi Proteasome A-type and B-type family protein 0.0029 0.0466 0.0466
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0029 0.0466 0.0466
Loa Loa (eye worm) proteasome subunit beta type 2 0.0029 0.0466 0.0376
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0029 0.0466 0.0178
Loa Loa (eye worm) PAS-3 protein 0.0029 0.0466 0.0376
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0029 0.0466 0.0466
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0029 0.0466 0.0466
Leishmania major proteasome alpha 1 subunit, putative 0.0029 0.0466 0.0178
Loa Loa (eye worm) proteasome subunit beta type 1 0.0029 0.0466 0.0376
Echinococcus multilocularis proteasome subunit alpha type 6 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Onchocerca volvulus Cathepsin F homolog 0.0023 0.0293 0.5362
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0029 0.0466 0.0466
Toxoplasma gondii proteasome subunit alpha type, putative 0.0029 0.0466 0.0178
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0029 0.0466 0.0178
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0029 0.0466 0.0466
Plasmodium falciparum proteasome subunit beta type-5 0.0386 1 1
Mycobacterium ulcerans proteasome PrcB 0.0386 1 1
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0029 0.0466 0.0466
Toxoplasma gondii peptidase, T1 family protein 0.0029 0.0466 0.0178
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0029 0.0466 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Brugia malayi Cathepsin L-like precursor 0.0015 0.0093 0.0093
Echinococcus multilocularis cysteine protease 0.0023 0.0293 0.0293
Echinococcus granulosus proteasome subunit alpha type 2 0.0029 0.0466 0.0466
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0029 0.0466 0.0466
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0029 0.0466 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0293 0.0293
Echinococcus granulosus proteasome subunit beta t family 0.0029 0.0466 0.0466
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0029 0.0466 0.0376
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0029 0.0466 0.0466
Echinococcus multilocularis proteasome subunit alpha type 2 0.0029 0.0466 0.0466
Echinococcus granulosus proteasome subunit beta type 6 0.0029 0.0466 0.0466
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0029 0.0466 0.0466
Loa Loa (eye worm) fibroinase 0.0023 0.0293 0.0202
Leishmania major proteasome alpha 3 subunit, putative 0.0029 0.0466 0.0178
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit beta type-7, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0029 0.0466 0.0466
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0029 0.0466 0.0466
Toxoplasma gondii proteasome subunit 0.0029 0.0466 0.0178
Brugia malayi Cathepsin L-like precursor 0.0023 0.0293 0.0293
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0029 0.0466 0.0466
Echinococcus multilocularis proteasome (prosome, macropain) 0.0386 1 1
Onchocerca volvulus 0.0023 0.0293 0.5362
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0029 0.0466 0.0178
Echinococcus granulosus Proteasome subunit alpha type 7 0.0029 0.0466 0.0466
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0293 0.0293
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0029 0.0466 0.0466
Brugia malayi Cathepsin L-like precursor 0.0023 0.0293 0.0293
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0029 0.0466 0.0466
Leishmania major proteasome alpha 2 subunit, putative 0.0029 0.0466 0.0178
Echinococcus granulosus cathepsin l1 0.0015 0.0093 0.0093
Trypanosoma cruzi 20S proteasome subunit 0.0029 0.0466 0.0466
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0029 0.0466 0.0466
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit beta type-6, putative 0.0029 0.0466 0.0466
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0293 0.0293
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0029 0.0466 0.0466
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0029 0.0466 0.0466
Echinococcus granulosus proteasome subunit beta type 7 0.0029 0.0466 0.0466
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0029 0.0466 0.0466
Leishmania major proteasome alpha 7 subunit, putative 0.0029 0.0466 0.0178
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0029 0.0466 0.0466
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0029 0.0466 0.0178
Brugia malayi Cathepsin L-like precursor 0.0023 0.0293 0.0293
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0029 0.0466 0.0466
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.0293 0.0293
Leishmania major proteasome alpha 7 subunit, putative 0.0029 0.0466 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0293 0.0293
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0386 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0029 0.0466 0.0466
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0029 0.0466 0.0466
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.0293 0.0293
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0293 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Brugia malayi Proteasome subunit alpha type 7-1 0.0029 0.0466 0.0466
Brugia malayi Proteasome A-type and B-type family protein 0.0029 0.0466 0.0466
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0029 0.0466 0.0466
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0029 0.0466 0.0178
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.0293 0.0293
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Onchocerca volvulus 0.0023 0.0293 0.5362
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0029 0.0466 0.0376
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0029 0.0466 0.0466
Echinococcus multilocularis proteasome subunit beta type 7 0.0029 0.0466 0.0466
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0029 0.0466 0.0466
Onchocerca volvulus 0.0023 0.0293 0.5362
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0093 0.0093
Brugia malayi Cathepsin L-like precursor 0.0023 0.0293 0.0293
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0029 0.0466 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Leishmania major proteasome beta 5 subunit, putative 0.0386 1 1
Echinococcus granulosus subfamily T1A non peptidase ue 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit beta type-2, putative 0.0029 0.0466 0.0466
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0029 0.0466 0.0466
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0029 0.0466 0.0466
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit beta type-5, putative 0.0386 1 1
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0029 0.0466 0.0466
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0029 0.0466 0.0178
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0029 0.0466 0.0466
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0029 0.0466 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0293 0.0293
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0386 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0386 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0293 0.0293
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0386 1 1
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0386 1 1
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0386 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0029 0.0466 0.0466
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.0293 0.0293
Echinococcus granulosus proteasome subunit alpha type 6 0.0029 0.0466 0.0466
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0386 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0029 0.0466 0.0466
Brugia malayi Cathepsin L-like cysteine proteinase 0.0015 0.0093 0.0093
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0029 0.0466 0.0466
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0029 0.0466 0.0466
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0029 0.0466 0.0466
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0029 0.0466 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0029 0.0466 0.0466
Leishmania major proteasome beta 3 subunit, putative 0.0029 0.0466 0.0178
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0386 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0029 0.0466 0.0466
Brugia malayi proteasome subunit beta type 2 0.0029 0.0466 0.0466
Brugia malayi proteasome subunit beta type 1 0.0029 0.0466 0.0466
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0029 0.0466 0.0466
Leishmania major proteasome alpha 1 subunit, putative 0.0029 0.0466 0.0178
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Loa Loa (eye worm) cysteine protease 0.0023 0.0293 0.0202
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0293 0.0293
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0029 0.0466 0.0466
Toxoplasma gondii proteasome subunit beta type, putative 0.0386 1 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0029 0.0466 0.0466
Onchocerca volvulus 0.0023 0.0293 0.5362
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0029 0.0466 0.0466
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0029 0.0466 0.0178
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0029 0.0466 0.0466
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0029 0.0466 0.0466
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0029 0.0466 0.0466
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0029 0.0466 0.0466
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0029 0.0466 0.0466
Brugia malayi Cathepsin L-like precursor 0.0023 0.0293 0.0293
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0029 0.0466 0.0466
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0029 0.0466 0.0466
Brugia malayi Proteasome A-type and B-type family protein 0.0029 0.0466 0.0466
Leishmania major proteasome beta 2 subunit, putative 0.0029 0.0466 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0029 0.0466 0.0466
Echinococcus granulosus proteasome prosome macropain 0.0386 1 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0029 0.0466 0.0178
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.0293 0.0202
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0029 0.0466 0.0466
Echinococcus granulosus cathepsin l1 0.0023 0.0293 0.0293
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit beta type-4, putative 0.0029 0.0466 0.0466
Brugia malayi proteasome subunit alpha type 1 0.0029 0.0466 0.0466
Brugia malayi proteasome subunit alpha type 3 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0029 0.0466 0.0466
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0029 0.0466 0.0376
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0029 0.0466 0.0466
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0029 0.0466 0.0178
Brugia malayi proteasome subunit alpha type 2 0.0029 0.0466 0.0466
Onchocerca volvulus Notchless protein homolog 0.0029 0.0466 1
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0029 0.0466 0.0466
Leishmania major proteasome beta 7 subunit, putative 0.0029 0.0466 0.0178
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.0293 0.0293
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0029 0.0466 0.0466
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0029 0.0466 0.0466
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0293 0.0293
Loa Loa (eye worm) proteasome subunit beta type 3 0.0029 0.0466 0.0376
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0029 0.0466 0.0466
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0029 0.0466 0.0178
Onchocerca volvulus 0.0023 0.0293 0.5362
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0029 0.0466 0.0466
Toxoplasma gondii heat shock protein hslv, putative 0.0029 0.0466 0.0178
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0293 0.0293
Brugia malayi proteasome subunit alpha type 4 0.0029 0.0466 0.0466
Echinococcus granulosus Proteasome subunit alpha beta 0.0029 0.0466 0.0466
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0029 0.0466 0.0466
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0029 0.0466 0.0466
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0293 0.5362
Brugia malayi proteasome subunit alpha type 6 0.0029 0.0466 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Onchocerca volvulus 0.0023 0.0293 0.5362
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0029 0.0466 0.0466
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0029 0.0466 0.0376
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0029 0.0466 0.0178
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0029 0.0466 0.0466
Brugia malayi Cathepsin L-like precursor 0.0023 0.0293 0.0293
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0029 0.0466 0.0466
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0029 0.0466 0.0466
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0029 0.0466 0.0376
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0029 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0023 0.0293 0.0202
Plasmodium falciparum proteasome subunit beta type-4 0.0029 0.0466 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0029 0.0466 0.0376
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0015 0.0093 0.0093
Plasmodium vivax proteasome subunit beta type-3, putative 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0029 0.0466 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0293 0.0293
Plasmodium vivax vivapain-2 0.0023 0.0293 0.0293
Entamoeba histolytica cysteine protease, putative 0.0023 0.0293 0.0293
Toxoplasma gondii proteasome subunit alpha1, putative 0.0029 0.0466 0.0178
Brugia malayi cathepsin L-like precursor 0.0015 0.0093 0.0093
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0029 0.0466 0.0466
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0293 0.5362
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0386 1 1
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0029 0.0466 0.0466
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0029 0.0466 0.0466
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0293 0.0293
Trypanosoma brucei proteasome beta 7 subunit 0.0029 0.0466 0.0466
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0293 0.0293
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0029 0.0466 0.0466
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0093 0.0093
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0029 0.0466 0.0466
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0293 0.0293
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0029 0.0466 0.0466
Trypanosoma brucei proteasome alpha 7 subunit 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0029 0.0466 0.0466
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0029 0.0466 0.0178
Plasmodium vivax proteasome subunit beta type-1, putative 0.0029 0.0466 0.0466
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0029 0.0466 0.0178
Leishmania major proteasome beta 2 subunit, putative 0.0029 0.0466 0.0178
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0029 0.0466 0.0466
Brugia malayi Proteasome subunit alpha type 1 0.0029 0.0466 0.0466
Brugia malayi Cathepsin L-like precursor 0.0015 0.0093 0.0093
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0029 0.0466 0.0466
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0029 0.0466 0.0466
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0029 0.0466 0.0466
Brugia malayi proteasome subunit beta type 3 0.0029 0.0466 0.0466
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0029 0.0466 0.0466
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0386 1 1
Onchocerca volvulus 0.0023 0.0293 0.5362
Brugia malayi 20S proteasome alpha5 subunit 0.0029 0.0466 0.0466
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0029 0.0466 0.0466
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0029 0.0466 0.0376
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0029 0.0466 0.0466
Loa Loa (eye worm) ctsf protein 0.0023 0.0293 0.0202
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0029 0.0466 0.0466
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0029 0.0466 0.0466
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0029 0.0466 0.0466
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0029 0.0466 0.0466
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0029 0.0466 0.0466
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0029 0.0466 0.0466
Trypanosoma brucei proteasome beta 6 subunit 0.0029 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0293 0.0293
Plasmodium vivax vivapain-2 0.0023 0.0293 0.0293
Toxoplasma gondii proteasome beta subunit 0.0029 0.0466 0.0178
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0293 0.0293
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0029 0.0466 0.0466

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.