TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 418.528 | Formula: C26H30N2O3
H donors: 2 H acceptors: 3 LogP: 3.59 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: C=C[C@@]1(C)CC[C@H]2[C@]3(C1(C#N)[C@H]1O[C@H]1C(C1=Nc4c([C@]31O)c(C2(C)C)ccc4)(C)C)O
InChi: 1S/C26H30N2O3/c1-7-23(6)12-11-16-21(2,3)14-9-8-10-15-17(14)25(29)20(28-15)22(4,5)18-19(31-18)24(23,13-27)26(16,25)30/h7-10,16,18-19,29-30H,1,11-12H2,2-6H3/t16-,18-,19+,23+,24?,25-,26+/m1/s1
InChiKey: JNFLCQAQLNNMTM-CCZGIPDWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0029	0.0466	0.0466
Leishmania major	proteasome beta 2 subunit, putative	0.0029	0.0466	0.0178
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0029	0.0466	0.0466
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0029	0.0466	0.0466
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0293	0.0293
Echinococcus granulosus	proteasome subunit beta t family	0.0029	0.0466	0.0466
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0029	0.0466	0.0466
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0386	1	1
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0029	0.0466	0.0376
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0293	0.0293
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0029	0.0466	0.0178
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0029	0.0466	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0386	1	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0029	0.0466	0.0466
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0293	0.0293
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0386	1	1
Toxoplasma gondii	heat shock protein hslv, putative	0.0029	0.0466	0.0178
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0029	0.0466	0.0466
Brugia malayi	proteasome subunit alpha type 2	0.0029	0.0466	0.0466
Leishmania major	proteasome alpha 1 subunit, putative	0.0029	0.0466	0.0178
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0029	0.0466	0.0466
Echinococcus granulosus	proteasome subunit beta type 6	0.0029	0.0466	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0029	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0293	0.0202
Entamoeba histolytica	cysteine proteinase, putative	0.0015	0.0093	0.0093
Trypanosoma cruzi	20S proteasome subunit	0.0029	0.0466	0.0466
Leishmania major	proteasome beta 3 subunit, putative	0.0029	0.0466	0.0178
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0029	0.0466	0.0466
Brugia malayi	proteasome subunit beta type 3	0.0029	0.0466	0.0466
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0029	0.0466	0.0466
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0029	0.0466	0.0376
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0293	0.0293
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0029	0.0466	0.0178
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0023	0.0293	0.0202
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0029	0.0466	0.0466
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0029	0.0466	0.0466
Leishmania major	proteasome alpha 3 subunit, putative	0.0029	0.0466	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0029	0.0466	0.0466
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0093	0.0093
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0029	0.0466	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0029	0.0466	0.0466
Echinococcus granulosus	Proteasome subunit alpha beta	0.0029	0.0466	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0293	0.0293
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0029	0.0466	0.0466
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0029	0.0466	0.0466
Toxoplasma gondii	peptidase, T1 family protein	0.0029	0.0466	0.0178
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0029	0.0466	0.0466
Brugia malayi	proteasome subunit alpha type 3	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0029	0.0466	0.5
Plasmodium falciparum	proteasome subunit beta type-5	0.0386	1	1
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0029	0.0466	0.0466
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0029	0.0466	0.0178
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0029	0.0466	0.0466
Echinococcus multilocularis	proteasome subunit beta type 6	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0029	0.0466	0.0466
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0029	0.0466	0.0466
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0386	1	1
Brugia malayi	20S proteasome alpha5 subunit	0.0029	0.0466	0.0466
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0029	0.0466	0.0466
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0029	0.0466	0.0178
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0015	0.0093	0.0093
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0029	0.0466	0.0466
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0029	0.0466	0.0466
Echinococcus granulosus	proteasome subunit beta type 7	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Echinococcus multilocularis	cysteine protease	0.0023	0.0293	0.0293
Trypanosoma brucei	proteasome alpha 7 subunit	0.0029	0.0466	0.0466
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0029	0.0466	0.0376
Loa Loa (eye worm)	PAS-3 protein	0.0029	0.0466	0.0376
Echinococcus granulosus	cathepsin l1	0.0015	0.0093	0.0093
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0029	0.0466	0.0466
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0029	0.0466	0.0466
Echinococcus granulosus	proteasome prosome macropain	0.0386	1	1
Onchocerca volvulus		0.0023	0.0293	0.5362
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0029	0.0466	0.0466
Plasmodium vivax	vivapain-2	0.0023	0.0293	0.0293
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0029	0.0466	0.0466
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0023	0.0293	0.0293
Leishmania major	proteasome beta 5 subunit, putative	0.0386	1	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0029	0.0466	0.0178
Brugia malayi	cathepsin L-like precursor	0.0015	0.0093	0.0093
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0023	0.0293	0.0293
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0029	0.0466	0.0466
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0293	0.0293
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0029	0.0466	0.0466
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0386	1	1
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0029	0.0466	0.0466
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0029	0.0466	0.0466
Onchocerca volvulus	Notchless protein homolog	0.0029	0.0466	1
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0029	0.0466	0.0376
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0386	1	1
Loa Loa (eye worm)	fibroinase	0.0023	0.0293	0.0202
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0029	0.0466	0.0466
Leishmania major	proteasome alpha 7 subunit, putative	0.0029	0.0466	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0093	0.0093
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0029	0.0466	0.0466
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0029	0.0466	0.0466
Brugia malayi	Cathepsin L-like precursor	0.0015	0.0093	0.0093
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0029	0.0466	0.0178
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0029	0.0466	0.0466
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0386	1	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0029	0.0466	0.0466
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0029	0.0466	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Mycobacterium ulcerans	proteasome PrcB	0.0386	1	1
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0293	0.0293
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Brugia malayi	proteasome subunit alpha type 6	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0029	0.0466	0.0178
Brugia malayi	Proteasome A-type and B-type family protein	0.0029	0.0466	0.0466
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0029	0.0466	0.0466
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0029	0.0466	0.0466
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0029	0.0466	0.0466
Brugia malayi	proteasome subunit beta type 1	0.0029	0.0466	0.0466
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0029	0.0466	0.0466
Onchocerca volvulus	Cathepsin L homolog	0.0023	0.0293	0.5362
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0293	0.0293
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0029	0.0466	0.0466
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0029	0.0466	0.0466
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0029	0.0466	0.0466
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit beta type-4	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0029	0.0466	0.0466
Echinococcus multilocularis	cathepsin L cysteine protease	0.0023	0.0293	0.0293
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0029	0.0466	0.0466
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0029	0.0466	0.0376
Onchocerca volvulus	Cathepsin F homolog	0.0023	0.0293	0.5362
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0029	0.0466	0.0466
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0293	0.0293
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0029	0.0466	0.0466
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0029	0.0466	0.0466
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0293	0.0293
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0029	0.0466	0.0178
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0029	0.0466	0.0466
Brugia malayi	proteasome subunit alpha type 4	0.0029	0.0466	0.0466
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0029	0.0466	0.0466
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0029	0.0466	0.0466
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0023	0.0293	0.0202
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0386	1	1
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0029	0.0466	0.0466
Leishmania major	proteasome alpha 2 subunit, putative	0.0029	0.0466	0.0178
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0293	0.0293
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0029	0.0466	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Brugia malayi	Proteasome A-type and B-type family protein	0.0029	0.0466	0.0466
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0029	0.0466	0.0376
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0029	0.0466	0.0466
Leishmania major	proteasome beta 2 subunit, putative	0.0029	0.0466	0.0178
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0029	0.0466	0.0466
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0029	0.0466	0.0466
Trypanosoma cruzi	cruzipain precursor, putative	0.0023	0.0293	0.0293
Loa Loa (eye worm)	ctsf protein	0.0023	0.0293	0.0202
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0015	0.0093	0.0093
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0029	0.0466	0.0466
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Echinococcus granulosus	proteasome subunit alpha type 6	0.0029	0.0466	0.0466
Brugia malayi	Proteasome subunit alpha type 7-1	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0029	0.0466	0.0466
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0029	0.0466	0.0466
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0029	0.0466	0.0466
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0029	0.0466	0.0466
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0029	0.0466	0.0466
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0023	0.0293	0.0293
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0029	0.0466	0.0466
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0093	0.0093
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0029	0.0466	0.0178
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0029	0.0466	0.0466
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0029	0.0466	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome beta subunit	0.0029	0.0466	0.0178
Onchocerca volvulus		0.0023	0.0293	0.5362
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0029	0.0466	0.0376
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0029	0.0466	0.0466
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0386	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0015	0.0093	0.0093
Onchocerca volvulus		0.0023	0.0293	0.5362
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0029	0.0466	0.0466
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0293	0.0293
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0293	0.0293
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0029	0.0466	0.0466
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0023	0.0293	0.0293
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0029	0.0466	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0029	0.0466	0.0466
Leishmania major	proteasome alpha 1 subunit, putative	0.0029	0.0466	0.0178
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0029	0.0466	0.0466
Echinococcus multilocularis	proteasome subunit beta type 7	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0029	0.0466	0.0466
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0029	0.0466	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0029	0.0466	0.0376
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0029	0.0466	0.0178
Brugia malayi	Proteasome A-type and B-type family protein	0.0029	0.0466	0.0466
Loa Loa (eye worm)	cysteine protease	0.0023	0.0293	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0023	0.0293	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Onchocerca volvulus		0.0023	0.0293	0.5362
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0029	0.0466	0.0466
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0029	0.0466	0.0466
Echinococcus granulosus	proteasome subunit alpha type 2	0.0029	0.0466	0.0466
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0029	0.0466	0.0376
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Brugia malayi	proteasome subunit alpha type 1	0.0029	0.0466	0.0466
Leishmania major	proteasome alpha 7 subunit, putative	0.0029	0.0466	0.0178
Brugia malayi	proteasome subunit beta type 2	0.0029	0.0466	0.0466
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0029	0.0466	0.0466
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0029	0.0466	0.0466
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0029	0.0466	0.0466
Onchocerca volvulus		0.0023	0.0293	0.5362
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0029	0.0466	0.0376
Echinococcus multilocularis	cysteine protease	0.0023	0.0293	0.0293
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0029	0.0466	0.0466
Echinococcus multilocularis	cathepsin L cysteine protease	0.0023	0.0293	0.0293
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0029	0.0466	0.0466
Leishmania major	proteasome beta 7 subunit, putative	0.0029	0.0466	0.0178
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0029	0.0466	0.0466
Brugia malayi	Proteasome subunit alpha type 1	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0023	0.0293	0.0293
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0029	0.0466	0.0178
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Trypanosoma brucei	proteasome beta 6 subunit	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome subunit	0.0029	0.0466	0.0178
Trypanosoma brucei	proteasome beta 7 subunit	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0029	0.0466	0.0466
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0029	0.0466	0.0178
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0029	0.0466	0.0466
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0029	0.0466	0.0178
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0029	0.0466	0.0466
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0029	0.0466	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0293	0.0293
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0386	1	1
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0386	1	1
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0029	0.0466	0.0178
Onchocerca volvulus	Cathepsin L homolog	0.0023	0.0293	0.5362
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0029	0.0466	0.0466
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0029	0.0466	0.0466
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0293	0.0293
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0029	0.0466	0.0178
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0023	0.0293	0.0293
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0029	0.0466	0.0466
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0029	0.0466	0.0466
Echinococcus granulosus	cathepsin l1	0.0023	0.0293	0.0293
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0029	0.0466	0.0376
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0386	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0029	0.0466	0.0466
Onchocerca volvulus		0.0023	0.0293	0.5362
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Leishmania major	proteasome beta-1 subunit, putative	0.0029	0.0466	0.0178
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0293	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0293	0.0293
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0029	0.0466	0.0376
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0023	0.0293	0.0293
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0029	0.0466	0.0178
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0029	0.0466	0.0466
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0029	0.0466	0.0466
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0029	0.0466	0.0466
Toxoplasma gondii	proteasome subunit beta type, putative	0.0386	1	1
Plasmodium vivax	vivapain-2	0.0023	0.0293	0.0293
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.0293	0.0293
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Onchocerca volvulus		0.0023	0.0293	0.5362
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0029	0.0466	0.0466
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0029	0.0466	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0293	0.0293
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0023	0.0293	0.0293

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 468018

Bibliographic References

No literature references available for this target.

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Detailed information for compound 412148