Detailed information for compound 420390

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 305.369 | Formula: C17H23NO4
  • H donors: 0 H acceptors: 2 LogP: 3.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C)ccc1OC(=O)[C@H]1CCCN1C(=O)C(C)C
  • InChi: 1S/C17H23NO4/c1-11(2)16(19)18-9-5-6-13(18)17(20)22-14-8-7-12(3)10-15(14)21-4/h7-8,10-11,13H,5-6,9H2,1-4H3/t13-/m1/s1
  • InChiKey: WTJYXABAKKLTMH-CYBMUJFWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.052 0.052
Echinococcus granulosus Tubulin alpha 1 chain 0.0037 0.0792 0.0792
Echinococcus granulosus protein kinase c iota type 0.0187 0.5797 0.5797
Echinococcus granulosus nuclear factor of activated T cells 5 0.0283 0.9 0.9
Schistosoma mansoni hypothetical protein 0.0076 0.2072 0.2072
Trichomonas vaginalis dexras1, putative 0.0028 0.0473 0.0649
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0572 0.0572
Echinococcus multilocularis Tubulin beta 2C chain 0.0059 0.1516 0.1516
Loa Loa (eye worm) tubulin alpha chain 0.0037 0.0792 0.1076
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0038
Leishmania major beta tubulin 0.0059 0.1516 1
Leishmania major beta tubulin 0.0059 0.1516 1
Schistosoma mansoni tubulin subunit alpha 0.0037 0.0792 0.0792
Trypanosoma brucei epsilon tubulin 0.0029 0.0512 0.3004
Mycobacterium tuberculosis Conserved protein 0.0034 0.0669 0.0886
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.3068 0.4495
Leishmania major beta tubulin 0.0059 0.1516 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0159
Trichomonas vaginalis tubulin beta chain, putative 0.0037 0.0792 0.1088
Echinococcus granulosus Tubulin beta 2C chain 0.0059 0.1516 0.1516
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.0117 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0572 0.0777
Brugia malayi conserved hypotetical protein 0.0015 0.0029 0.004
Plasmodium falciparum tubulin epsilon chain, putative 0.0029 0.0512 0.3004
Echinococcus granulosus protein kinase C gamma type 0.0017 0.0117 0.0117
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0552 0.0552
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0552 0.0552
Toxoplasma gondii cathepsin B 0.0029 0.0528 0.3116
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0088 0.0088
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0572 0.0777
Onchocerca volvulus 0.0015 0.0029 0.004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.7367 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0059 0.1516 0.2058
Echinococcus granulosus tubulin alpha 3 chain 0.0037 0.0792 0.0792
Brugia malayi Hemopexin family protein 0.0024 0.0356 0.0484
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.109 0.1518
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.003 0.0552 0.3282
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0572 0.0777
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0669 0.0669
Onchocerca volvulus 0.0016 0.0092 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.2523 0.2523
Loa Loa (eye worm) tubulin alpha 2 0.0025 0.0373 0.0506
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0572 0.0572
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0021 0.0245 0.0337
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0038 0.0051
Toxoplasma gondii beta-tubulin, putative 0.0059 0.1516 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0572 0.0777
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0245 0.0333
Entamoeba histolytica Ras family GTPase 0.0028 0.0473 0.3119
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0669 0.0919
Loa Loa (eye worm) hypothetical protein 0.0029 0.052 0.0706
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0026 0.0429 0.0429
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.109 0.109
Brugia malayi steroid hormone receptor 0.0031 0.0572 0.0777
Echinococcus granulosus tubulin alpha 1C chain 0.0037 0.0792 0.0792
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0038 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.052 0.3063
Loa Loa (eye worm) alpha-tubulin 0.0037 0.0792 0.1076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.052 0.052
Loa Loa (eye worm) DR-78 0.0015 0.0029 0.004
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.0669 0.0886
Echinococcus granulosus tubulin alpha chain 0.0037 0.0792 0.0792
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0792 0.0792
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.3068 0.4495
Echinococcus granulosus tubulin alpha 3 chain 0.0037 0.0792 0.0792
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Entamoeba histolytica protein kinase, putative 0.0017 0.0117 0.0769
Leishmania major beta tubulin 0.0059 0.1516 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0572 0.0572
Trichomonas vaginalis tubulin beta chain, putative 0.0037 0.0792 0.1088
Brugia malayi beta-tubulin, identical 0.0059 0.1516 0.2058
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.109 0.109
Echinococcus multilocularis Tubulin beta 2C chain 0.0059 0.1516 0.1516
Leishmania major epsilon tubulin, putative 0.0029 0.0512 0.3004
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0572 0.0777
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0669 1
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0029 0.0029
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0283 0.9 0.9
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0029 0.0029
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0026 0.0429 0.0582
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0242 0.0243
Entamoeba histolytica protein kinase, putative 0.0017 0.0117 0.0769
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.0777
Plasmodium vivax tubulin alpha chain, putative 0.0037 0.0792 0.4959
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.122 0.4668
Trichomonas vaginalis tubulin epsilon chain, putative 0.0059 0.1516 0.2082
Loa Loa (eye worm) beta-lactamase 0.0034 0.0669 0.0908
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0572 0.0572
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Brugia malayi follicle stimulating hormone receptor 0.0234 0.7367 1
Brugia malayi Hr1 repeat family protein 0.0017 0.0117 0.0158
Trichomonas vaginalis tubulin, putative 0.0059 0.1516 0.2082
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Echinococcus granulosus Tubulin beta 2C chain 0.0059 0.1516 0.1516
Schistosoma mansoni zinc finger protein 0.0015 0.0029 0.0029
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0215 0.6727 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0029 0.0512 0.0703
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.122 0.4668
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0092 0.0126
Echinococcus granulosus serine:threonine protein kinase N2 0.0017 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Echinococcus multilocularis Tubulin alpha 1 chain 0.0037 0.0792 0.0792
Toxoplasma gondii ABC1 family protein 0.0034 0.0669 0.4101
Trichomonas vaginalis CMGC family protein kinase 0.005 0.122 0.1676
Loa Loa (eye worm) tubulin beta-4 chain 0.0059 0.1516 0.2058
Brugia malayi tubulin alpha chain - mouse 0.0037 0.0792 0.1076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0572 0.0777
Trypanosoma brucei alpha tubulin 0.0037 0.0792 0.4959
Plasmodium falciparum tubulin gamma chain 0.0029 0.0512 0.3004
Schistosoma mansoni tar DNA-binding protein 0.0059 0.1523 0.1523
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0029 0.004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0572 0.0572
Brugia malayi nuclear receptor RXR 0.0016 0.0088 0.0119
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Echinococcus multilocularis Tubulin alpha 1 chain 0.0037 0.0792 0.0792
Echinococcus granulosus Tubulin beta 2C chain 0.0059 0.1516 0.1516
Echinococcus multilocularis tar DNA binding protein 0.0059 0.1523 0.1523
Mycobacterium ulcerans hydrolase 0.0021 0.0242 0.2747
Loa Loa (eye worm) alpha-tubulin 0.0037 0.0792 0.1076
Leishmania major beta tubulin 0.0059 0.1516 1
Echinococcus multilocularis tubulin alpha 0.0029 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0119
Echinococcus granulosus cathepsin b 0.0089 0.2523 0.2523
Loa Loa (eye worm) tubulin beta-2A chain 0.0059 0.1516 0.2058
Brugia malayi nuclear receptor RXR 0.0015 0.0029 0.004
Loa Loa (eye worm) matrixin family protein 0.0038 0.0814 0.1105
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0029 0.0029
Brugia malayi Matrixin family protein 0.0017 0.0117 0.0159
Treponema pallidum NADH oxidase 0.0016 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.0777
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0119
Schistosoma mansoni jun-related protein 0.0076 0.2072 0.2072
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0016 0.0092 0.0126
Trichomonas vaginalis esterase, putative 0.0034 0.0669 0.0919
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0025 0.0373 0.0506
Schistosoma mansoni tubulin subunit beta 0.0059 0.1516 0.1516
Schistosoma mansoni tubulin subunit beta 0.0059 0.1516 0.1516
Brugia malayi nuclear receptor NHR-67 0.0015 0.0029 0.004
Echinococcus granulosus tubulin subunit TubB 0.0037 0.0792 0.0792
Schistosoma mansoni tubulin subunit epsilon 0.0029 0.0512 0.0512
Leishmania major hypothetical protein, conserved 0.0034 0.0669 0.4101
Loa Loa (eye worm) hypothetical protein 0.0089 0.2523 0.3425
Echinococcus granulosus Tubulin beta 2C chain 0.0059 0.1516 0.1516
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.2523 0.2523
Onchocerca volvulus 0.0024 0.0356 0.0489
Brugia malayi alpha-tubulin 0.0037 0.0792 0.1076
Echinococcus granulosus beta tubulin 0.0059 0.1516 0.1516
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0029 0.0528 0.3116
Loa Loa (eye worm) Ras protein let-60 0.0028 0.0473 0.0642
Leishmania major beta tubulin 0.0059 0.1516 1
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0029 0.004
Giardia lamblia Beta tubulin 0.0059 0.1516 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.0777
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.3461 0.5087
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0038 0.0038
Brugia malayi Tubulin alpha-2 chain 0.0037 0.0792 0.1076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0572 0.0777
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0029 0.004
Brugia malayi tailless protein 0.0015 0.0029 0.004
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.0669 0.0886
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.3461 0.5087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0572 0.0777
Giardia lamblia Cathepsin B precursor 0.0029 0.0528 0.3116
Brugia malayi Tubulin alpha-2 chain 0.0037 0.0792 0.1076
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0669 0.2411
Loa Loa (eye worm) hypothetical protein 0.0034 0.0669 0.0908
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0572 0.0572
Trichomonas vaginalis GTP-binding protein rit, putative 0.0028 0.0473 0.0649
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.122 0.794
Echinococcus multilocularis tubulin alpha 3 chain 0.0037 0.0792 0.0792
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0029 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0572 0.0572
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.052 0.052
Brugia malayi hypothetical protein 0.0015 0.0029 0.004
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0115 0.3382 0.3382
Brugia malayi tubulin alpha-2 chain 0.0037 0.0792 0.1076
Echinococcus granulosus tubulin alpha chain 0.0037 0.0792 0.0792
Brugia malayi nuclear receptor NHR-88 0.0015 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0669 0.0908
Echinococcus granulosus ras gtpase 0.0028 0.0473 0.0473
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0029 0.004
Leishmania major beta tubulin 0.0059 0.1516 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Onchocerca volvulus 0.0232 0.7282 1
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0669 0.2411
Echinococcus granulosus tubulin alpha chain 0.0037 0.0792 0.0792
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0038
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0029 0.004
Plasmodium vivax tubulin alpha chain, putative 0.0037 0.0792 0.4959
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0552 0.0552
Brugia malayi Pre-SET motif family protein 0.0029 0.052 0.0706
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0025 0.0373 0.0512
Schistosoma mansoni tar DNA-binding protein 0.0059 0.1523 0.1523
Entamoeba histolytica protein kinase, putative 0.0017 0.0117 0.0769
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0528 0.0725
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0089 0.2523 0.2523
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0792 0.0792
Plasmodium falciparum thioredoxin reductase 0.0046 0.109 0.7028
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Echinococcus multilocularis Tubulin beta 2C chain 0.0059 0.1516 0.1516
Brugia malayi bZIP transcription factor family protein 0.0093 0.2654 0.3603
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.1102 0.1495
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.122 0.794
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0093 0.2654 0.2654
Echinococcus multilocularis protein kinase c epsilon type 0.0029 0.0505 0.0505
Schistosoma mansoni tubulin subunit alpha 0.0037 0.0792 0.0792
Giardia lamblia Gamma tubulin 0.0029 0.0512 0.3004
Brugia malayi nuclear hormone receptor 0.0015 0.0029 0.004
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0029 0.004
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0029 0.0512 0.3004
Loa Loa (eye worm) AGC/NDR protein kinase 0.0017 0.0117 0.0158
Echinococcus granulosus tubulin alpha chain 0.0037 0.0792 0.0792
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0669 0.4101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0572 0.0777
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0572 0.0777
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0609 0.0827
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0119
Brugia malayi Protein kinase domain containing protein 0.0017 0.0117 0.0158
Trypanosoma brucei tubulin gamma chain 0.0029 0.0512 0.3004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0572 0.0777
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.122 0.122
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Trichomonas vaginalis CMGC family protein kinase 0.005 0.122 0.1676
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0572 0.0572
Echinococcus multilocularis GPCR, family 2 0.0015 0.0038 0.0038
Onchocerca volvulus Matrilysin homolog 0.0017 0.0117 0.0161
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0572 0.0572
Brugia malayi RNA binding protein 0.0059 0.1523 0.2067
Plasmodium falciparum alpha tubulin 1 0.0037 0.0792 0.4959
Schistosoma mansoni tar DNA-binding protein 0.0059 0.1523 0.1523
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0092 0.0126
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0059 0.1523 0.2067
Plasmodium falciparum tubulin beta chain 0.0059 0.1516 1
Toxoplasma gondii alpha tubulin TUBA1 0.0037 0.0792 0.4959
Plasmodium falciparum alpha tubulin 2 0.0037 0.0792 0.4959
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0029 0.0029
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0026 0.0429 0.0429
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0572 0.0572
Trypanosoma brucei trypanothione reductase 0.0046 0.109 0.7028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0089 0.2523 0.2523
Schistosoma mansoni tubulin subunit beta 0.0059 0.1516 0.1516
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.0777
Schistosoma mansoni nuclear receptor 0.0015 0.0029 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0669 0.0919
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0016 0.0082 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.005 0.122 0.1676
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0025 0.0373 0.0506
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.052 0.052
Echinococcus multilocularis tubulin subunit beta 0.0059 0.1516 0.1516
Plasmodium falciparum glutathione reductase 0.0046 0.109 0.7028
Echinococcus multilocularis tubulin gamma 1 chain 0.0029 0.0512 0.0512
Trichomonas vaginalis set domain proteins, putative 0.0232 0.7282 1
Onchocerca volvulus Matrilysin homolog 0.0038 0.0814 0.1118
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.008 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.122 0.4668
Schistosoma mansoni tubulin subunit gamma 0.0029 0.0512 0.0512
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0029 0.0029
Echinococcus multilocularis tubulin beta 1 chain 0.0059 0.1516 0.1516
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0017 0.0117 0.0117
Echinococcus granulosus tubulin alpha chain 0.0037 0.0792 0.0792
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.109 0.7028
Brugia malayi protein kinase C II. 0.0029 0.0505 0.0685
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0029 0.004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0572 0.0572
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0117 0.0117
Entamoeba histolytica ras-1, putative 0.0028 0.0473 0.3119
Toxoplasma gondii alpha-tubulin I, putative 0.0037 0.0792 0.4959
Trypanosoma brucei beta tubulin 0.0029 0.0512 0.3004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0669 0.0908
Echinococcus granulosus Tubulin beta 2C chain 0.0059 0.1516 0.1516
Mycobacterium ulcerans hypothetical protein 0.0034 0.0669 1
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0029 0.004
Plasmodium vivax glutathione reductase, putative 0.0046 0.109 0.7028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0572 0.0777
Trichomonas vaginalis tubulin beta chain, putative 0.0037 0.0792 0.1088
Trichomonas vaginalis tubulin epsilon chain, putative 0.0037 0.0792 0.1088
Echinococcus multilocularis tubulin alpha 1C chain 0.0037 0.0792 0.0792
Schistosoma mansoni hypothetical protein 0.0313 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0669 0.0919
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.109 0.1479
Loa Loa (eye worm) AGC/AKT protein kinase 0.0017 0.0117 0.0158
Onchocerca volvulus 0.0017 0.0117 0.0161
Trichomonas vaginalis tubulin gamma chain, putative 0.0029 0.0512 0.0703
Brugia malayi hypothetical protein 0.0016 0.0088 0.0119
Leishmania major beta tubulin 0.0059 0.1516 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.0669 0.0886
Entamoeba histolytica tubulin alpha-1 chain 0.0037 0.0792 0.5225
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.3068 0.4495
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.0777
Echinococcus granulosus tubulin alpha 0.0029 0.0512 0.0512
Trypanosoma cruzi beta tubulin, putative 0.0059 0.1516 0.5879
Mycobacterium tuberculosis Conserved protein 0.0034 0.0669 0.0886
Onchocerca volvulus 0.0029 0.052 0.0714
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0117 0.0117
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0092 0.0126
Echinococcus multilocularis cathepsin b 0.0089 0.2523 0.2523
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0119
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0017 0.0117 0.0158
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0029 0.0029
Echinococcus granulosus beta tubulin 0.0059 0.1516 0.1516
Echinococcus multilocularis jun protein 0.0093 0.2654 0.2654
Giardia lamblia Cathepsin B precursor 0.0029 0.0528 0.3116
Echinococcus multilocularis Tubulin beta 2C chain 0.0059 0.1516 0.1516
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Trypanosoma brucei alpha tubulin 0.0037 0.0792 0.4959
Loa Loa (eye worm) hypothetical protein 0.0037 0.0792 0.1076
Leishmania major gamma-tubulin 0.0029 0.0512 0.3004
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.122 0.4668
Brugia malayi hypothetical protein 0.0073 0.1987 0.2697
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.008 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.1102 0.1495
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0088 0.0088
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0117 0.0117
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.1102 0.1495
Echinococcus multilocularis protein kinase c iota type 0.0187 0.5797 0.5797
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0017 0.0117 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0059 0.1523 0.1523
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0038
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Echinococcus multilocularis cathepsin b 0.0089 0.2523 0.2523
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0669 0.0908
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0038 0.0051
Schistosoma mansoni tubulin subunit alpha 0.0037 0.0792 0.0792
Trypanosoma cruzi epsilon tubulin, putative 0.0029 0.0512 0.1766
Brugia malayi Matrixin family protein 0.0017 0.0117 0.0159
Echinococcus multilocularis tubulin epsilon chain 0.0029 0.0512 0.0512
Mycobacterium ulcerans beta-lactamase 0.0034 0.0669 1
Trypanosoma cruzi alpha tubulin, putative 0.0037 0.0792 0.2915
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0792 0.0792
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0017 0.0117 0.0117
Trypanosoma brucei alpha tubulin 0.0037 0.0792 0.4959
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0669 0.0669
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0029 0.0528 0.1832
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0088 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0572 0.0777
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0158
Loa Loa (eye worm) tubulin gamma chain 0.0029 0.0512 0.0695
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0183 0.5649 0.7668
Trypanosoma brucei rac serine-threonine kinase, putative 0.0017 0.0117 0.0253
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0059 0.1516 0.1516
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0088 0.0119
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0029 0.004
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0572 0.0777
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0115 0.3382 0.3382
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0572 0.0777
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0062 0.1626 0.1626
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0572 0.0777
Brugia malayi hypothetical protein 0.0015 0.0029 0.004
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0026 0.0429 0.0582
Entamoeba histolytica tubulin alpha chain, putative 0.0037 0.0792 0.5225
Echinococcus granulosus Tubulin alpha 1 chain 0.0037 0.0792 0.0792
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0115 0.3382 0.3382
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0088 0.0119
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0017 0.0117 0.0117
Echinococcus granulosus tubulin alpha 1C chain 0.0037 0.0792 0.0792
Loa Loa (eye worm) BEN-1 protein 0.0059 0.1516 0.2058
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.0117 0.0117
Schistosoma mansoni coup transcription factor 0.0031 0.0572 0.0572
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0093 0.2654 0.2654
Loa Loa (eye worm) hypothetical protein 0.0021 0.0242 0.0329
Trichomonas vaginalis tubulin gamma chain, putative 0.0029 0.0512 0.0703
Echinococcus granulosus tar DNA binding protein 0.0059 0.1523 0.1523
Trichomonas vaginalis tubulin epsilon chain, putative 0.0059 0.1516 0.2082
Loa Loa (eye worm) hypothetical protein 0.0047 0.1102 0.1495
Entamoeba histolytica tubulin family protein 0.0059 0.1516 1
Trypanosoma brucei beta tubulin 0.0059 0.1516 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.122 0.122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0159
Echinococcus multilocularis tubulin alpha 1C chain 0.0037 0.0792 0.0792
Trypanosoma brucei alpha tubulin 0.0037 0.0792 0.4959
Giardia lamblia Kinase, CMGC MAPK 0.005 0.122 0.794
Leishmania major beta tubulin 0.0059 0.1516 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0041 0.0904 0.0904
Trichomonas vaginalis tubulin, putative 0.0016 0.0092 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0029 0.0029
Onchocerca volvulus 0.0034 0.0669 0.0919
Schistosoma mansoni serine/threonine kinase 0.0017 0.0117 0.0117
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Schistosoma mansoni thyroid hormone receptor 0.0146 0.4409 0.4409
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0669 0.0669
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.122 0.1657
Entamoeba histolytica protein kinase, putative 0.0017 0.0117 0.0769
Echinococcus granulosus tubulin subunit beta 0.0059 0.1516 0.1516
Toxoplasma gondii beta-1 tubulin, putative 0.0059 0.1516 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0119
Brugia malayi Tubulin gamma chain 0.0029 0.0512 0.0695
Schistosoma mansoni nuclear receptor 0.0015 0.0029 0.0029
Loa Loa (eye worm) tubulin alpha-3 chain 0.0021 0.0245 0.0333
Echinococcus granulosus Tubulin alpha 1 chain 0.0037 0.0792 0.0792
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0029 0.0029
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0037 0.0792 0.1088
Echinococcus granulosus Protein kinase C brain isozyme 0.0029 0.0505 0.0505
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0552 0.3282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.0777
Plasmodium vivax tubulin gamma chain, putative 0.0029 0.0512 0.3004
Brugia malayi Ras-related protein R-Ras2 0.0028 0.0473 0.0642
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0669 0.0919
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0669 0.4101
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0552 0.0552
Echinococcus multilocularis tubulin alpha 3 chain 0.0037 0.0792 0.0792
Brugia malayi beta-lactamase 0.0034 0.0669 0.0908
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Echinococcus multilocularis ras gtpase 0.0028 0.0473 0.0473
Loa Loa (eye worm) tubulin alpha-2 chain 0.0037 0.0792 0.1076
Brugia malayi Protein kinase domain containing protein 0.0017 0.0117 0.0158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0669 0.0908
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0572 0.0572
Entamoeba histolytica tubulin family protein 0.0059 0.1516 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0029 0.0029
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0062 0.1626 0.1626
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0029 0.0505 0.0685
Schistosoma mansoni tubulin subunit beta 0.0059 0.1516 0.1516
Echinococcus multilocularis hypothetical protein 0.0037 0.0792 0.0792
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.0669 0.0886
Onchocerca volvulus 0.0031 0.0572 0.0786
Loa Loa (eye worm) cathepsin B 0.0029 0.0528 0.0716
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0505 0.0505
Schistosoma mansoni hypothetical protein 0.0024 0.0356 0.0356
Brugia malayi TAR-binding protein 0.0059 0.1523 0.2067
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.008 0.008
Brugia malayi nuclear hormone receptor 0.0031 0.0572 0.0777
Toxoplasma gondii AGC kinase 0.0017 0.0117 0.0253
Loa Loa (eye worm) tubulin alpha 2 0.0025 0.0373 0.0506
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0572 0.0572
Trichomonas vaginalis tubulin alpha chain, putative 0.0059 0.1516 0.2082
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.3068 0.4495
Brugia malayi Protein kinase domain containing protein 0.0017 0.0117 0.0158
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.008 0.008
Echinococcus multilocularis serine:threonine protein kinase 38 0.0017 0.0117 0.0117
Trichomonas vaginalis tubulin epsilon chain, putative 0.0037 0.0792 0.1088
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0572 0.0777
Brugia malayi glutathione reductase 0.0046 0.109 0.1479
Echinococcus granulosus tubulin beta 1 chain 0.0059 0.1516 0.1516
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0572 0.0572
Giardia lamblia Beta tubulin 0.0059 0.1516 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0059 0.1516 0.1516
Trichomonas vaginalis tubulin beta chain, putative 0.0037 0.0792 0.1088
Schistosoma mansoni tubulin subunit beta 0.0059 0.1516 0.1516
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0572 0.0786
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0029 0.0505 0.0505
Plasmodium vivax tubulin beta chain, putative 0.0059 0.1516 1
Leishmania major alpha tubulin 0.0037 0.0792 0.4959
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.008 0.5
Brugia malayi beta-lactamase family protein 0.0034 0.0669 0.0908
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Echinococcus multilocularis Tubulin beta 2C chain 0.0059 0.1516 0.1516
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0029 0.0029
Trichomonas vaginalis ras-dva small GTPase, putative 0.0028 0.0473 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0572 0.0777
Echinococcus multilocularis Tubulin alpha 1 chain 0.0037 0.0792 0.0792
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0572 0.0777
Trypanosoma cruzi tubulin gamma chain 0.0029 0.0512 0.1766
Echinococcus granulosus GPCR family 2 0.0015 0.0038 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.052 0.052
Loa Loa (eye worm) TAR-binding protein 0.0059 0.1523 0.2067
Brugia malayi RNA recognition motif domain containing protein 0.0059 0.1523 0.2067
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.3068 0.4495
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0669 0.0669
Trypanosoma brucei alpha tubulin, putative 0.0016 0.0092 0.0082
Leishmania major beta tubulin 0.0059 0.1516 1
Onchocerca volvulus 0.0034 0.0669 0.0919
Trypanosoma brucei cysteine peptidase C (CPC) 0.0029 0.0528 0.3116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0029 0.0029
Giardia lamblia Alpha-tubulin 0.0037 0.0792 0.4959
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0572 0.0777
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.4409 0.4409
Echinococcus multilocularis peroxisome assembly protein 26 0.0037 0.0792 0.0792
Mycobacterium tuberculosis Conserved protein 0.0034 0.0669 0.0886
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0088 0.0119
Loa Loa (eye worm) hypothetical protein 0.0032 0.0609 0.0827
Schistosoma mansoni hypothetical protein 0.0032 0.0609 0.0609
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0669 0.0908
Loa Loa (eye worm) hypothetical protein 0.003 0.0552 0.0749
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0528 0.0528
Brugia malayi ecdysteroid receptor 0.0031 0.0572 0.0777
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0572 0.0572
Trichomonas vaginalis CMGC family protein kinase 0.005 0.122 0.1676
Leishmania major beta tubulin 0.0059 0.1516 1
Giardia lamblia Cathepsin B precursor 0.0029 0.0528 0.3116
Echinococcus granulosus protein kinase c epsilon type 0.0029 0.0505 0.0505
Brugia malayi Tubulin beta-1 chain 0.0059 0.1516 0.2058
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.008 0.011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Brugia malayi Matrixin family protein 0.0017 0.0117 0.0159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0572 0.0572
Echinococcus multilocularis beta tubulin 0.0059 0.1516 0.1516
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0572 0.0777
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0242 0.0329
Loa Loa (eye worm) hypothetical protein 0.0028 0.0473 0.0642
Plasmodium vivax SET domain protein, putative 0.0029 0.052 0.3063
Schistosoma mansoni tubulin subunit beta 0.0059 0.1516 0.1516
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0572 0.0572
Loa Loa (eye worm) RNA binding protein 0.0059 0.1523 0.2067
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0669 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0117 0.0117
Leishmania major trypanothione reductase 0.0046 0.109 0.7028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.0669 0.0886
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0029 0.0029
Trypanosoma brucei beta tubulin 0.0059 0.1516 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0089 0.2523 0.3425
Mycobacterium leprae Probable lipase LipE 0.0034 0.0669 0.1327
Trypanosoma brucei epsilon tubulin 0.0029 0.0512 0.3004
Echinococcus granulosus tubulin epsilon chain 0.0029 0.0512 0.0512
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.0669 0.0886
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.0117 0.0158
Leishmania major beta tubulin 0.0059 0.1516 1
Trypanosoma cruzi epsilon tubulin, putative 0.0029 0.0512 0.1766
Echinococcus multilocularis geminin 0.0313 1 1
Loa Loa (eye worm) BEN-1 protein 0.0059 0.1516 0.2058
Loa Loa (eye worm) hypothetical protein 0.0034 0.0669 0.0908
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.0777
Loa Loa (eye worm) hypothetical protein 0.0034 0.0669 0.0908
Echinococcus granulosus alpha tubulin 0.0037 0.0792 0.0792
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0017 0.0117 0.0117
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0017 0.0117 0.0158
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.109 0.4132
Schistosoma mansoni memapsin-2 (A01 family) 0.0215 0.672 0.672
Brugia malayi Ras protein let-60 0.0028 0.0473 0.0642
Brugia malayi Tubulin alpha chain 0.0037 0.0792 0.1076
Schistosoma mansoni atypical protein kinase C 0.0199 0.6186 0.6186
Brugia malayi nuclear receptor NHR-88 0.0031 0.0572 0.0777
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0484 0.0484
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.008 0.5
Trypanosoma brucei epsilon tubulin 0.0029 0.0512 0.3004
Schistosoma mansoni tar DNA-binding protein 0.0059 0.1523 0.1523
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0088 0.0088
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.122 0.794
Brugia malayi Tubulin beta chain 0.0016 0.0092 0.0125
Echinococcus granulosus cathepsin b 0.0089 0.2523 0.2523
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.3068 0.8779
Loa Loa (eye worm) AGC/PKN protein kinase 0.0017 0.0117 0.0158
Leishmania major beta tubulin 0.0059 0.1516 1
Echinococcus granulosus jun protein 0.0093 0.2654 0.2654
Brugia malayi ecdysone receptor 0.0015 0.0029 0.004
Echinococcus granulosus tubulin gamma 1 chain 0.0029 0.0512 0.0512
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0017 0.0117 0.0117
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0572 0.0572
Brugia malayi Matrixin family protein 0.0017 0.0117 0.0159
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0029 0.004
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0814 0.1118
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0117 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0572 0.0777
Trypanosoma brucei beta tubulin 0.0059 0.1516 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.0669 0.0886
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0017 0.0117 0.0158
Leishmania major beta tubulin 0.0059 0.1516 1
Plasmodium vivax tubulin epsilon chain, putative 0.0029 0.0512 0.3004
Leishmania major beta tubulin 0.0059 0.1516 1
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0792 0.0792
Echinococcus granulosus peroxisome assembly protein 26 0.0037 0.0792 0.0792
Schistosoma mansoni hypothetical protein 0.0313 1 1
Leishmania major beta tubulin 0.0059 0.1516 1
Echinococcus multilocularis beta tubulin 0.0059 0.1516 0.1516
Giardia lamblia Beta tubulin 0.0059 0.1516 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Schistosoma mansoni thyroid hormone receptor 0.0146 0.4409 0.4409
Trichomonas vaginalis tubulin beta chain, putative 0.0059 0.1516 0.2082
Mycobacterium ulcerans lipase LipD 0.0034 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0117 0.0159
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0572 0.0786
Brugia malayi Matrixin family protein 0.0041 0.0929 0.1261
Loa Loa (eye worm) matrixin family protein 0.0041 0.0929 0.1261
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.0777
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0029 0.0029
Trichomonas vaginalis tubulin beta chain, putative 0.0037 0.0792 0.1088
Onchocerca volvulus 0.0034 0.0669 0.0919
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.122 0.122
Entamoeba histolytica tubulin gamma chain 0.0029 0.0512 0.3375
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0029 0.0029
Entamoeba histolytica Ras family GTPase 0.0028 0.0473 0.3119
Trichomonas vaginalis tubulin gamma chain, putative 0.0059 0.1516 0.2082
Schistosoma mansoni alpha tubulin 0.0037 0.0792 0.0792
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0572 0.0777
Brugia malayi beta-lactamase family protein 0.0034 0.0669 0.0908
Brugia malayi MAP kinase sur-1 0.005 0.122 0.1657
Trypanosoma brucei beta tubulin 0.0059 0.1516 1
Echinococcus granulosus mitogen activated protein kinase 0.005 0.122 0.122
Trichomonas vaginalis rap1 and, putative 0.0028 0.0473 0.0649
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0089 0.2523 1
Trichomonas vaginalis tubulin, putative 0.0016 0.0092 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0572 0.0777
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.3461 0.5087
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0117 0.016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.6343 0.8611
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0669 0.1327
Brugia malayi protein kinase C3,putative 0.0171 0.526 0.7141
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.3461 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0572 0.0572
Trypanosoma brucei protein kinase, putative 0.005 0.122 0.794
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0572 0.0572
Echinococcus granulosus NDR protein kinase 0.0017 0.0117 0.0117
Brugia malayi Pre-SET motif family protein 0.0204 0.6343 0.8611
Echinococcus multilocularis serine threonine protein kinase 0.0017 0.0117 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0117 0.0117
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.008 0.011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.004
Onchocerca volvulus 0.0073 0.1987 0.2728
Toxoplasma gondii beta tubulin 0.0059 0.1516 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.122 0.122
Schistosoma mansoni alpha tubulin 0.0037 0.0792 0.0792
Trichomonas vaginalis tubulin beta chain, putative 0.0037 0.0792 0.1088
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0092 0.0126
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0792 0.0792
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.052 0.052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0572 0.0786
Loa Loa (eye worm) beta-tubulin 0.0059 0.1516 0.2058
Loa Loa (eye worm) glutathione reductase 0.0046 0.109 0.1479
Loa Loa (eye worm) tubulin alpha chain 0.0037 0.0792 0.1076
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0505 0.0505
Toxoplasma gondii thioredoxin reductase 0.0046 0.109 0.7028
Mycobacterium tuberculosis Probable reductase 0.0106 0.3068 0.4495
Leishmania major beta tubulin 0.0059 0.1516 1
Brugia malayi Thioredoxin reductase 0.0046 0.109 0.1479
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0572 0.0572
Brugia malayi hypothetical protein 0.0016 0.0088 0.0119
Trichomonas vaginalis ral, putative 0.0028 0.0473 0.0649
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0669 0.0919
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0505 0.0505
Giardia lamblia Alpha-tubulin 0.0037 0.0792 0.4959
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0572 0.0572
Loa Loa (eye worm) tubulin beta chain 0.0059 0.1516 0.2058
Leishmania major beta tubulin 0.0059 0.1516 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.008 0.0109
Trichomonas vaginalis rheb, putative 0.0028 0.0473 0.0649
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0017 0.0117 0.0158
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0572 0.0572
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0091 0.2569 0.3487
Onchocerca volvulus 0.0015 0.0029 0.004
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.122 0.794
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0572 0.0572
Schistosoma mansoni alpha tubulin 0.0037 0.0792 0.0792
Echinococcus multilocularis tubulin subunit TubB 0.0037 0.0792 0.0792
Schistosoma mansoni hypothetical protein 0.0047 0.1121 0.1121
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0572 0.0572

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of Fischer 344 rat brain acetylcholine esterase at 0.6 mM ChEMBL. 17126019
Activity (functional) 0 Inhibition of Fe(II)/ascorbate-induced lipid peroxidation in Fischer 344 rat hepatic microsomal membranes ChEMBL. 17126019
Activity (binding) 0 Inhibition of Fischer 344 rat brain acetylcholine esterase at 0.6 mM ChEMBL. 17126019
Activity (functional) = 79.3 % Increase of oedema in BALB/c mouse with FCA-induced inflammation at 0.30 mmol/kg, ip ChEMBL. 17126019
Activity (functional) = 79.3 % Increase of oedema in BALB/c mouse with FCA-induced inflammation at 0.30 mmol/kg, ip ChEMBL. 17126019
Inhibition (functional) = 1 % Anti-inflammatory activity against of FCA-induced odema in BALB/c mouse asssessed as oedema inhibition at 0.30 mmol/kg, ip ChEMBL. 17126019
Inhibition (functional) = 1 % Anti-inflammatory activity against of FCA-induced odema in BALB/c mouse asssessed as oedema inhibition at 0.30 mmol/kg, ip ChEMBL. 17126019
Inhibition (binding) = 42 % Inhibition of soybean lipoxygenase at 0.3 mM ChEMBL. 17126019
Inhibition (binding) = 42 % Inhibition of soybean lipoxygenase at 0.3 mM ChEMBL. 17126019

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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