Detailed information for compound 455719

Basic information

Technical information
  • TDR Targets ID: 455719
  • Name: 4-(pyridin-4-ylmethylsulfanyl)-1H-pyrazolo[3, 4-d]pyrimidine
  • MW: 243.288 | Formula: C11H9N5S
  • H donors: 1 H acceptors: 4 LogP: 1.44 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: n1ccc(cc1)CSc1ncnc2c1cn[nH]2
  • InChi: 1S/C11H9N5S/c1-3-12-4-2-8(1)6-17-11-9-5-15-16-10(9)13-7-14-11/h1-5,7H,6H2,(H,13,14,15,16)
  • InChiKey: FGWLSABIEOZVJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-pyridylmethylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine
  • 4-(4-pyridylmethylthio)-1H-pyrazolo[3,4-d]pyrimidine
  • 4-(pyridin-4-ylmethylsulfanyl)-1H-pyrazolo[4,3-e]pyrimidine
  • 4-(4-pyridylmethylsulfanyl)-1H-pyrazolo[4,3-e]pyrimidine
  • 4-(4-pyridylmethylthio)-1H-pyrazolo[4,3-e]pyrimidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.006 0.0192
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.002 0.0091 0.0219
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0086 0.036
Leishmania major farnesyltransferase beta subunit 0.002 0.0091 0.0386
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0273 0.2174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0172 0.0547
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0021 0.0067
Brugia malayi Peptidase family C54 containing protein 0.0115 0.0786 0.25
Loa Loa (eye worm) DRP-1 protein 0.0021 0.0102 0.0102
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0091 0.0602
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0172 0.0547
Echinococcus granulosus heat shock protein 0.0045 0.0273 0.087
Echinococcus multilocularis dynamin 0.0021 0.0102 0.0324
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.002 0.0091 0.029
Schistosoma mansoni cpg binding protein 0.0031 0.0172 0.0548
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0175 0.0556
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0086 0.0274
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0273 0.1142
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0021 0.0179
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0086 0.0285
Schistosoma mansoni vesicular acetylcholine transporter 0.0438 0.3143 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0018 0.0156
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0028
Plasmodium falciparum phd finger protein, putative 0.0031 0.0175 0.1345
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0045 0.0275 0.1147
Plasmodium vivax geranylgeranyltransferase, putative 0.002 0.0091 0.0602
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.002 0.0091 0.029
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0021 0.0089
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0115 0.0786 0.328
Plasmodium falciparum dynamin-like protein 0.0021 0.0102 0.0718
Leishmania major GTP-binding protein, putative 0.0021 0.0102 0.0431
Echinococcus multilocularis peregrin 0.0031 0.0175 0.0556
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0096 0.0651 0.2571
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0172 0.0547
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0115 0.0786 0.4514
Loa Loa (eye worm) RecQ helicase 0.0023 0.0119 0.0119
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0119 0.048
Echinococcus multilocularis geminin 0.033 0.2356 0.7494
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0021 0.0067
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0254 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.006 0.0251
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0069
Schistosoma mansoni survival motor neuron protein 0.0047 0.0293 0.0932
Schistosoma mansoni protein phosphatase 2C 0.001 0.0021 0.0067
Onchocerca volvulus 0.0331 0.2363 0.2238
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0188 0.1323 0.5522
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0091 0.029
Trichomonas vaginalis dynamin, putative 0.0021 0.0102 0.0379
Trypanosoma cruzi dynamin-1-like protein 0.0021 0.0102 0.0425
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0226 0.1133
Plasmodium vivax heat shock protein, putative 0.0169 0.1182 1
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0547
Plasmodium falciparum heat shock protein 90 0.0045 0.0273 0.2193
Schistosoma mansoni cpg binding protein 0.0029 0.016 0.051
Brugia malayi PHD-finger family protein 0.0031 0.0175 0.0556
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0438 0.3143 0.3143
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0033 0.0106
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0115 0.0786 0.3326
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0039 0.0163
Echinococcus granulosus endoplasmin 0.0042 0.0254 0.0806
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0172 0.0547
Echinococcus granulosus cpg binding protein 0.0031 0.0172 0.0548
Loa Loa (eye worm) heat shock protein 75 0.003 0.0164 0.0164
Schistosoma mansoni DNA helicase recq5 0.001 0.0018 0.0058
Plasmodium vivax endoplasmin, putative 0.0045 0.0273 0.2174
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0848 0.0848
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0175 0.148
Schistosoma mansoni protein farnesyltransferase subunit beta 0.002 0.0091 0.029
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.016 0.016
Toxoplasma gondii Hsp90 domain-containing protein 0.0169 0.1182 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0656 0.0656
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0254 0.1738
Echinococcus granulosus heat shock protein 90 0.0045 0.0273 0.087
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.002 0.0091 0.029
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0273 0.0985
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0172 0.0547
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0086 0.0274
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0273 0.1142
Echinococcus multilocularis heat shock protein 90 0.0038 0.0226 0.072
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0273 0.0985
Echinococcus granulosus cysteine protease atg4b 0.0115 0.0786 0.25
Onchocerca volvulus 0.0331 0.2363 0.2238
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0115 0.0786 0.25
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0091 0.0314
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0045 0.0275 0.2325
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0175 0.0175
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0021 0.0067
Echinococcus granulosus dynamin 0.0021 0.0102 0.0324
Echinococcus multilocularis Peptidase C54 0.0115 0.0786 0.25
Plasmodium falciparum cysteine protease ATG4, putative 0.0045 0.0275 0.2204
Plasmodium falciparum geranylgeranyltransferase, putative 0.002 0.0091 0.0625
Entamoeba histolytica peptidase, C54 family 0.0045 0.0275 0.0991
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0254 0.1296
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0115 0.0786 0.4514
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0092 0.0618 0.0618
Schistosoma mansoni DNA helicase recq1 0.001 0.0018 0.0058
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0102 0.0425
Loa Loa (eye worm) hypothetical protein 0.0053 0.0337 0.0337
Echinococcus multilocularis cysteine protease atg4b 0.0115 0.0786 0.25
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0547
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0273 0.1142
Trypanosoma brucei heat shock protein, putative 0.0045 0.0273 0.1142
Trypanosoma brucei Sterol methyltransferase, putative 0.0188 0.1323 0.5522
Echinococcus multilocularis dynamin 1 protein 0.0021 0.0102 0.0324
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0083 0.0264
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0092 0.0618 0.1966
Leishmania major lanosterol synthase, putative 0.0316 0.2253 0.9534
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0848 0.2698
Schistosoma mansoni jumonji domain containing protein 0.001 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0023 0.0114 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0086 0.0285
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0273 0.1142
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0273 0.2314
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0175 0.148
Plasmodium falciparum heat shock protein 90, putative 0.0169 0.1182 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0091 0.0091
Toxoplasma gondii dynamin gtpase 0.0014 0.0049 0.0418
Loa Loa (eye worm) hypothetical protein 0.0097 0.0656 0.0656
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.006 0.0192
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1693 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0115 0.0786 0.4514
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1482 0.1482
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.006 0.0192
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.006 0.036
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.002 0.0091 0.0314
Toxoplasma gondii dynamin-related protein DRPA 0.0021 0.0102 0.0862
Schistosoma mansoni heat shock protein 0.0045 0.0273 0.087
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.002 0.0091 0.0219
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Giardia lamblia Dynamin 0.0021 0.0102 0.0348
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0091 0.0314
Giardia lamblia Prenyltransferase 0.002 0.0091 0.0303
Echinococcus granulosus geminin 0.033 0.2356 0.7494
Echinococcus granulosus vesicular acetylcholine transporter 0.0438 0.3143 1
Schistosoma mansoni cpg binding protein 0.0031 0.0172 0.0548
Echinococcus granulosus protein farnesyltransferase subunit beta 0.002 0.0091 0.029
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0273 0.1142
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0226 0.072
Schistosoma mansoni hypothetical protein 0.001 0.0022 0.007
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0022 0.0187
Loa Loa (eye worm) histone methyltransferase 0.001 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0848 0.2698
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0091 0.038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0656 0.2088
Entamoeba histolytica hypothetical protein 0.0036 0.0212 0.0729
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0086 0.0198
Entamoeba histolytica hypothetical protein 0.0036 0.0212 0.0729
Leishmania major phospholipase A1, putative 0.0331 0.2363 1
Trichomonas vaginalis dynamin, putative 0.0021 0.0102 0.0379
Trypanosoma brucei heat shock protein, putative 0.0045 0.0273 0.1142
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.006 0.006
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0188 0.1323 0.5522
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0406 0.1292
Trypanosoma cruzi lanosterol synthase, putative 0.0335 0.2396 1
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0235 0.0747
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0115 0.0786 0.328
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0021 0.0179
Trypanosoma brucei heat shock protein, putative 0.0045 0.0273 0.1142
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0331 0.2363 0.7517
Plasmodium falciparum endoplasmin, putative 0.0032 0.0184 0.1426
Toxoplasma gondii exonuclease III APE 0.0019 0.0086 0.0729
Brugia malayi hypothetical protein 0.0036 0.0212 0.0676
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0212 0.0676
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0022 0.0187
Echinococcus granulosus heat shock protein 90 0.0038 0.0226 0.072
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0091 0.0314
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0062 0.0524
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0264 0.0839
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0254 1
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Trichomonas vaginalis dynamin, putative 0.0021 0.0102 0.0379
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0009 0.0028
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0331 0.2363 0.2363
Giardia lamblia PHD finger protein 15 0.0031 0.0175 0.0652
Trypanosoma brucei phospholipase A1, putative 0.0331 0.2363 0.9862
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0226 0.0945
Entamoeba histolytica hypothetical protein 0.0096 0.0651 0.2571
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.006 0.0413
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0034
Trypanosoma brucei protein farnesyltransferase beta subunit 0.002 0.0091 0.038
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0091 0.0771
Schistosoma mansoni ap endonuclease 0.0019 0.0086 0.0274
Echinococcus granulosus phd:f box containing protein 0.001 0.0021 0.0067
Plasmodium falciparum protein farnesyltransferase subunit beta 0.002 0.0091 0.0625
Loa Loa (eye worm) RNA binding protein 0.0123 0.0848 0.0848
Brugia malayi Dynamin 0.0023 0.0114 0.0362
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0188 0.1323 0.5522
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0086 0.0283
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0273 0.1142
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0188 0.1323 0.5522
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0172 0.0547
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0235 0.0747
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0091 0.038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0028
Echinococcus multilocularis heat shock protein 90 0.0045 0.0273 0.087
Brugia malayi TAR-binding protein 0.0123 0.0848 0.2698
Brugia malayi jmjC domain containing protein 0.001 0.0021 0.0067
Entamoeba histolytica hypothetical protein 0.0036 0.0212 0.0729
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0273 0.0273
Brugia malayi jmjC domain containing protein 0.0102 0.0691 0.2198
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0223 0.0708
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0091 0.0314
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0273 0.1142
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0235 0.0747
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0039 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0848 0.2698
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.006 0.0192
Entamoeba histolytica peptidase, C54 family 0.0045 0.0275 0.0991
Brugia malayi jmjC domain containing protein 0.001 0.0021 0.0067
Trypanosoma brucei heat shock protein, putative 0.0045 0.0273 0.1142
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0022 0.0092
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0119 0.048
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.002 0.0091 0.029
Schistosoma mansoni autophagin-1 (C54 family) 0.0115 0.0786 0.25
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0119 0.0377
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.002 0.0091 0.029
Brugia malayi AF-10 protein 0.001 0.0022 0.007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0086 0.0583
Schistosoma mansoni dynamin 0.0021 0.0102 0.0324
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0018 0.0156
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0152 0.1055 0.4405
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0164 0.0004
Loa Loa (eye worm) hypothetical protein 0.0066 0.0432 0.0432
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0091 0.0314
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0091 0.0314
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0184 0.0877
Trypanosoma cruzi lanosterol synthase, putative 0.0335 0.2396 1
Brugia malayi Phospholipase A2 family protein 0.0362 0.2592 0.8245
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0045 0.0275 0.1163
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0045 0.0275 0.1147
Echinococcus multilocularis cpg binding protein 0.0031 0.0172 0.0548
Echinococcus granulosus Peptidase C54 0.0115 0.0786 0.25
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0159 0.0507
Brugia malayi jmjC domain containing protein 0.0039 0.0235 0.0747
Loa Loa (eye worm) hypothetical protein 0.0118 0.0806 0.0806
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0212 0.0676
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0358 0.303
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0115 0.0786 0.4514
Trypanosoma cruzi phospholipase A1, putative 0.0331 0.2363 0.9862
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0432 0.1375
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0021 0.0021
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.002 0.0091 0.038
Brugia malayi PHD-finger family protein 0.0012 0.0034 0.0109
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.002 0.0091 0.0771
Brugia malayi Pre-SET motif family protein 0.0031 0.0172 0.0547
Brugia malayi Hsp90 protein 0.003 0.0164 0.0522
Trypanosoma brucei heat shock protein, putative 0.0045 0.0273 0.1142
Onchocerca volvulus 0.0031 0.0172 0.0012
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.002 0.0091 0.0314
Onchocerca volvulus 0.0047 0.0293 0.0135
Loa Loa (eye worm) hypothetical protein 0.0232 0.1639 0.1639
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0045 0.0275 0.1147
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0035 0.0119
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.006 0.051
Echinococcus granulosus tar DNA binding protein 0.0123 0.0848 0.2698
Brugia malayi hypothetical protein 0.0232 0.1639 0.5214
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0086 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0848 0.2698
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0273 0.1142
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0119 0.0377
Trypanosoma brucei heat shock protein, putative 0.0045 0.0273 0.1142
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0018 0.0058
Leishmania major sterol 24-c-methyltransferase, putative 0.0188 0.1323 0.5599
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0175 0.1324
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0137 0.1021
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0273 0.2314
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0188 0.1323 0.5522
Schistosoma mansoni hypothetical protein 0.0047 0.0293 0.0932
Trypanosoma cruzi heat shock protein, putative 0.003 0.0164 0.0686
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0018 0.0058
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0338 0.2418 1
Onchocerca volvulus Alhambra homolog 0.0031 0.0175 0.0015
Schistosoma mansoni phd/f-box containing protein 0.001 0.0021 0.0067
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0438 0.3143 0.3032
Trichomonas vaginalis dynamin, putative 0.0021 0.0102 0.0379
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0021 0.0067
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0098 0.0665 0.2776
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0172 0.0547
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.006 0.051
Entamoeba histolytica peptidase, C54 family 0.0045 0.0275 0.0991
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0086 0.0591
Schistosoma mansoni hypothetical protein 0.0066 0.0432 0.1375
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0021 0.0067
Entamoeba histolytica dynamin-like protein 0.0021 0.0102 0.0264
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0086 0.0274
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0273 0.1417
Giardia lamblia Grp94/Hsp90 0.0042 0.0254 0.098
Plasmodium falciparum JmjC domain-containing protein, putative 0.001 0.0021 0.0024
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0175 0.0556
Entamoeba histolytica peptidase, C54 family 0.0045 0.0275 0.0991
Echinococcus multilocularis endoplasmin 0.0042 0.0254 0.0806
Schistosoma mansoni endoplasmin 0.0045 0.0273 0.087
Brugia malayi CXXC zinc finger family protein 0.0029 0.016 0.051
Brugia malayi isocitrate dehydrogenase 0.0015 0.006 0.0192
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0083 0.0263
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0009 0.0028
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0035 0.0143
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.006 0.0251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0656 0.2088
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0022 0.0092
Trypanosoma brucei heat shock protein, putative 0.0045 0.0273 0.1142
Trichomonas vaginalis dynamin, putative 0.0021 0.0102 0.0379
Brugia malayi Dynamin central region family protein 0.0021 0.0102 0.0324
Echinococcus multilocularis heat shock protein 0.0045 0.0273 0.087
Schistosoma mansoni heat shock protein 0.0045 0.0273 0.087
Echinococcus granulosus bloom syndrome protein 0.0023 0.0119 0.0377
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0021 0.0102 0.0379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0172 0.0547
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0018 0.0018
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0172 0.1456
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0172 0.0547
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0039 0.0165
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0018 0.0058
Schistosoma mansoni hypothetical protein 0.0031 0.0175 0.0556
Loa Loa (eye worm) hypothetical protein 0.0115 0.0786 0.0786
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0691 0.2198
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0254 0.1296
Brugia malayi Isocitrate dehydrogenase 0.0015 0.006 0.0192
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0091 0.029
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1639 0.5214
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0063 0.0363
Toxoplasma gondii dynamin-related protein DRPB 0.0021 0.0102 0.0862
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0021 0.0067
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.006 0.0336
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0033 0.0106
Loa Loa (eye worm) hypothetical protein 0.0362 0.2592 0.2592
Brugia malayi Dynamin 0.0023 0.0114 0.0362
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0086 0.036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0086 0.34
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0091 0.029
Echinococcus granulosus GPCR family 2 0.0031 0.0172 0.0547
Loa Loa (eye worm) endoplasmin 0.0045 0.0273 0.0273
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0069
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0848 0.2698
Schistosoma mansoni hypothetical protein 0.033 0.2356 0.7494
Schistosoma mansoni hypothetical protein 0.0036 0.0212 0.0676
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0091 0.0303
Plasmodium vivax farnesyltransferase beta subunit, putative 0.002 0.0091 0.0602
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0172 0.0547
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0172
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0021 0.0067
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0152 0.1055 0.4405
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0264 0.0839
Brugia malayi Bromodomain containing protein 0.0031 0.0175 0.0556
Trypanosoma brucei heat shock protein, putative 0.0045 0.0273 0.1142
Schistosoma mansoni ap endonuclease 0.0019 0.0086 0.0274
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0172 0.0547
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0137 0.0593
Brugia malayi jmjC domain containing protein 0.001 0.0021 0.0067
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0164 0.0522
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0084 0.0352
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.006 0.0192
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0547
Treponema pallidum heat shock protein 90 0.0042 0.0254 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0021 0.0089
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0172 0.0547
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0164 0.0522
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0691 0.2198
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0254 1
Schistosoma mansoni heat shock protein 0.003 0.0164 0.0522
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0018 0.0058
Leishmania major heat shock protein, putative 0.003 0.0164 0.0695
Entamoeba histolytica peptidase, C54 family 0.0115 0.0786 0.314
Onchocerca volvulus Phospholipase A2 homolog 0.1376 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0175 0.0556
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0273 0.1063
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.006 0.0251
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0091 0.0314
Echinococcus granulosus dynamin 1 protein 0.0021 0.0102 0.0324
Brugia malayi jmjC domain containing protein 0.001 0.0021 0.0067
Leishmania major geranylgeranyltransferase, putative 0.002 0.0091 0.0386
Leishmania major hypothetical protein, conserved 0.001 0.0021 0.009
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0226 0.0867
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0235 0.0235
Plasmodium vivax heat shock protein 90, putative 0.003 0.0164 0.1233
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0184 0.0877
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0115 0.0786 0.4514
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0115 0.0786 0.25
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.002 0.0091 0.0219
Schistosoma mansoni endoplasmin 0.0045 0.0273 0.087
Schistosoma mansoni dynamin 0.0023 0.0114 0.0362
Plasmodium vivax dynamin protein, putative 0.0021 0.0102 0.0695
Brugia malayi heat shock protein 90 0.0045 0.0273 0.087
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0254 0.1073
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Trypanosoma brucei lanosterol synthase 0.0335 0.2396 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0018 0.0058
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0547
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0091 0.0091
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1639 0.5214
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.001 0.0021 0.0089
Entamoeba histolytica hypothetical protein 0.0036 0.0212 0.0729
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0172 0.0547
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0021
Echinococcus multilocularis GPCR, family 2 0.0031 0.0172 0.0547
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0095 0.0302
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0086 0.036
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.002 0.0091 0.038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0172
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0848 0.2698
Schistosoma mansoni hypothetical protein 0.033 0.2356 0.7494
Brugia malayi Endoplasmin precursor 0.0045 0.0273 0.087
Entamoeba histolytica dynamin-1-like protein, putative 0.0021 0.0102 0.0264
Trichomonas vaginalis dynamin, putative 0.0021 0.0102 0.0379
Trypanosoma cruzi phospholipase A1, putative 0.0331 0.2363 0.9862
Plasmodium vivax SET domain protein, putative 0.0031 0.0172 0.1299
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0086 0.0086
Onchocerca volvulus 0.0331 0.2363 0.2238
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0207 0.1459 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0172 0.0172
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0538 0.1712
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0086 0.056
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0164 0.0526
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0021 0.0067
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.006 0.0192
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0098 0.0683
Leishmania major sterol 24-c-methyltransferase, putative 0.0188 0.1323 0.5599
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0091 0.0625
Trichomonas vaginalis mgm1, putative 0.0021 0.0102 0.0379
Brugia malayi vesicular acetylcholine transporter unc-17 0.0438 0.3143 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0018 0.0058
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0293 0.0932
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0021 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0416 0.0416
Plasmodium vivax dynamin-like protein, putative 0.0021 0.0102 0.0695
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0848 0.0848
Echinococcus multilocularis dynamin 1 0.0023 0.0114 0.0362
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0091 0.038
Brugia malayi Pre-SET motif family protein 0.021 0.1482 0.4715
Loa Loa (eye worm) hypothetical protein 0.0031 0.0175 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0848 0.2698
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0091 0.029
Giardia lamblia DNA repair protein RAD52 0.0338 0.2418 1
Brugia malayi Cytochrome P450 family protein 0.0026 0.014 0.0446
Schistosoma mansoni dynamin 0.0023 0.0114 0.0362
Leishmania major heat shock protein 83-1 0.0045 0.0273 0.1158
Brugia malayi RNA binding protein 0.0123 0.0848 0.2698
Plasmodium falciparum dynamin-like protein 0.0021 0.0102 0.0718
Echinococcus granulosus dynamin 1 0.0023 0.0114 0.0362
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.006 0.0192
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.006 0.0255
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0102 0.0425
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0091 0.0771
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0164 0.0686
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0164 0.139
Onchocerca volvulus 0.0239 0.1693 0.1558
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.002 0.0091 0.029
Echinococcus multilocularis phd:f box containing protein 0.001 0.0021 0.0067
Onchocerca volvulus Phospholipase A2 homolog 0.0362 0.2592 0.2471
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.006 0.0251
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0212 0.0676
Echinococcus multilocularis vesicular acetylcholine transporter 0.0438 0.3143 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0091 0.038
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0226 0.0945
Echinococcus granulosus peregrin 0.0031 0.0175 0.0556
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.014 0.014

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 250 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ChEMBL. 17239593
MIC (functional) = 250 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ChEMBL. 17239593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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