Detailed information for compound 457583

Basic information

Technical information
  • TDR Targets ID: 457583
  • Name: 3-(4-chloro-2-cyclohexylphenoxy)propanoic aci d
  • MW: 282.763 | Formula: C15H19ClO3
  • H donors: 1 H acceptors: 2 LogP: 4.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCOc1ccc(cc1C1CCCCC1)Cl
  • InChi: 1S/C15H19ClO3/c16-12-6-7-14(19-9-8-15(17)18)13(10-12)11-4-2-1-3-5-11/h6-7,10-11H,1-5,8-9H2,(H,17,18)
  • InChiKey: ZHWIAECJQUFYPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-chloro-2-cyclohexyl-phenoxy)propanoic acid
  • 3-(4-chloro-2-cyclohexyl-phenoxy)propionic acid
  • BBV-012146

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin D2 receptor 2 Starlite/ChEMBL References
Homo sapiens prostaglandin D2 receptor (DP) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis rhodopsin orphan GPCR prostaglandin D2 receptor (DP) 359 aa 312 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax SET domain protein, putative 0.0033 0.0321 0.1049
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0094 0.125 0.1194
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0149 0.0167
Plasmodium falciparum glutathione reductase 0.0022 0.0149 0.0347
Leishmania major macrophage migration inhibitory factor-like protein 0.0177 0.2521 0.2473
Leishmania major trypanothione reductase 0.0063 0.0773 0.0714
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0246 0.3568 0.8726
Loa Loa (eye worm) hypothetical protein 0.0029 0.0262 0.036
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0034 0.0338 0.0806
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0445 0.1089
Onchocerca volvulus 0.0261 0.3811 0.5119
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0262 0.0531
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.0773 0.1061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0262 0.036
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0591 0.0811
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0136 0.1895 0.1843
Echinococcus multilocularis protein kinase shaggy 0.0051 0.0591 0.1427
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0149 0.0086
Brugia malayi hypothetical protein 0.0489 0.7284 1
Brugia malayi PHD-finger family protein 0.0013 0.0011 0.0015
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0445 0.1069
Echinococcus granulosus peregrin 0.0035 0.0349 0.0835
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0262 0.0389
Loa Loa (eye worm) hypothetical protein 0.028 0.4088 0.5612
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0149 0.0167
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0149 0.0086
Schistosoma mansoni hypothetical protein 0.0032 0.0309 0.0757
Loa Loa (eye worm) hypothetical protein 0.0034 0.0339 0.0465
Onchocerca volvulus 0.0055 0.0657 0.0687
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0232
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0149 0.0086
Schistosoma mansoni hypothetical protein 0.0032 0.0307 0.075
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.1116
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.125 0.1194
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0338 0.0276
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0119 0.0226
Echinococcus multilocularis apoptotic protease activating factor 1 0.0034 0.0339 0.0809
Onchocerca volvulus 0.0051 0.0591 0.0593
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0149 0.0086
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0262 0.0622
Mycobacterium ulcerans hypothetical protein 0.0029 0.0262 0.0389
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0232
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0149 0.0086
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0177 0.2521 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0034 0.0338 0.0806
Brugia malayi beta-lactamase family protein 0.0029 0.0262 0.036
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1396 0.3415
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0262 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0338 0.0276
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Trypanosoma brucei ISWI complex protein 0.0017 0.0076 0.0012
Plasmodium falciparum glutathione reductase 0.0063 0.0773 0.2887
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.0773 0.2887
Echinococcus multilocularis beta adrenergic receptor kinase 0.0103 0.1396 0.34
Brugia malayi hypothetical protein 0.0034 0.0339 0.0465
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0609 0.147
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.1116
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Schistosoma mansoni jumonji domain containing protein 0.0084 0.1097 0.2683
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0262 0.0531
Loa Loa (eye worm) hypothetical protein 0.0489 0.7284 1
Schistosoma mansoni ap endonuclease 0.0016 0.0064 0.0156
Schistosoma mansoni bromodomain containing protein 0.007 0.0885 0.2164
Loa Loa (eye worm) hypothetical protein 0.0032 0.0307 0.0421
Leishmania major protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative 0.0136 0.1895 0.1843
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0034 0.0338 0.0806
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0034 0.0338 0.0806
Echinococcus granulosus semaphorin 5B 0.0023 0.0169 0.0392
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0034 0.0338 0.0276
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.0773 0.1386
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0232
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Echinococcus granulosus caspase 2 0.0034 0.0339 0.0809
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0051 0.0591 0.1427
Schistosoma mansoni caspase-7 (C14 family) 0.0034 0.0339 0.0829
Leishmania major hypothetical protein, conserved 0.0034 0.0338 0.0276
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0034 0.0338 0.0806
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0061 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1396 0.3415
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0309 0.0757
Schistosoma mansoni hypothetical protein 0.0023 0.0169 0.0413
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.1116
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0262 0.0809
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0114 0.1563 0.1509
Brugia malayi hypothetical protein 0.0167 0.2365 0.3247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0149 0.0167
Loa Loa (eye worm) hypothetical protein 0.0078 0.101 0.1387
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0034 0.0338 0.0806
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.2521 0.6557
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0591 0.2305
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Plasmodium vivax glutathione reductase, putative 0.0063 0.0773 0.2887
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0609 0.147
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Giardia lamblia Macrophage migration inhibitory factor 0.0177 0.2521 0.6106
Echinococcus multilocularis hypothetical protein 0.0023 0.0169 0.0392
Plasmodium falciparum thioredoxin reductase 0.0063 0.0773 0.2887
Echinococcus multilocularis peregrin 0.0035 0.0349 0.0835
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0186 0.2657 0.5068
Brugia malayi Thioredoxin reductase 0.0063 0.0773 0.1061
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0198 0.0464
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0262 0.0531
Loa Loa (eye worm) hypothetical protein 0.0055 0.0661 0.0907
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0034 0.0338 0.0826
Loa Loa (eye worm) hypothetical protein 0.0029 0.0262 0.036
Leishmania major hypothetical protein, conserved 0.002 0.0119 0.0056
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Schistosoma mansoni zinc finger protein 0.0022 0.0148 0.0362
Loa Loa (eye worm) hypothetical protein 0.0055 0.0657 0.0902
Onchocerca volvulus Cell death protein 3 homolog 0.0034 0.0339 0.0239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0149 0.0086
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0051 0.0591 0.131
Schistosoma mansoni lozenge 0.0061 0.0755 0.1846
Leishmania major macrophage migration inhibitory factor-like protein 0.0177 0.2521 0.2473
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0833 0.1143
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.028 0.4088 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0246 0.3568 0.4899
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0034 0.0338 0.0464
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0321 0.0786
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0262 0.02
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0149 0.0212
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0246 0.3568 0.4899
Echinococcus multilocularis semaphorin 5B 0.0023 0.0169 0.0392
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0262 0.0389
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0034 0.0338 0.1116
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.028 0.4088 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Brugia malayi plexin A 0.0065 0.0811 0.1113
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0149 0.0086
Loa Loa (eye worm) hypothetical protein 0.0029 0.0262 0.036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0149 0.0212
Onchocerca volvulus Alhambra homolog 0.0032 0.0309 0.0198
Mycobacterium ulcerans hypothetical protein 0.0351 0.5181 1
Giardia lamblia hypothetical protein 0.0034 0.0338 0.0681
Mycobacterium tuberculosis Conserved protein 0.0029 0.0262 0.0389
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0262 0.0531
Schistosoma mansoni semaphorin 5-related 0.0023 0.0169 0.0413
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0119 0.0056
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0309 0.0425
Brugia malayi intracellular kinase 0.0051 0.0591 0.0811
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0119 0.0138
Mycobacterium tuberculosis Conserved protein 0.0029 0.0262 0.0389
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0591 0.1407
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0119 0.0226
Brugia malayi Bromodomain containing protein 0.0035 0.0349 0.048
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0034 0.0338 0.0806
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0034 0.0338 0.0806
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.028 0.4088 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0034 0.0338 0.1116
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0106 0.0237
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0064 0.0134
Brugia malayi beta-lactamase family protein 0.0029 0.0262 0.036
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0093 0.1234 0.3004
Mycobacterium tuberculosis Conserved protein 0.0029 0.0262 0.0389
Toxoplasma gondii thioredoxin reductase 0.0063 0.0773 0.1763
Schistosoma mansoni hypothetical protein 0.0017 0.0076 0.0186
Loa Loa (eye worm) hypothetical protein 0.0034 0.0339 0.0465
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0149 0.0086
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0034 0.0338 0.0276
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0034 0.0338 0.0732
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0309 0.0737
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.028 0.4088 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0149 0.0167
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0177 0.2521 0.6106
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0262 0.0389
Onchocerca volvulus Huntingtin homolog 0.0195 0.2793 0.3688
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Onchocerca volvulus 0.0029 0.0262 0.0132
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0309 0.0611
Loa Loa (eye worm) hypothetical protein 0.0167 0.2365 0.3247
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0591 0.0811
Echinococcus multilocularis plexin a4 0.0065 0.0811 0.1966
Leishmania major hypothetical protein, conserved 0.0017 0.0076 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0309 0.1001
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.028 0.4088 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0051 0.0591 0.0531
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0464
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0773 0.0714
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0262 0.0389
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0149 0.0086
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0051 0.0591 0.1427
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0316 0.4637 0.4603
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Brugia malayi jmjC domain containing protein 0.0105 0.1428 0.196
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Schistosoma mansoni zinc finger protein 0.0017 0.0076 0.0186
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0034 0.0338 0.0826
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0198 0.0484
Brugia malayi Pre-SET motif family protein 0.0033 0.0321 0.0441
Loa Loa (eye worm) hypothetical protein 0.0029 0.0262 0.036
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0149 0.0086
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0149 1
Plasmodium falciparum phd finger protein, putative 0.0032 0.0309 0.1001
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0034 0.0338 0.0806
Leishmania major cAMP-specific phosphodiesterase, putative 0.0034 0.0338 0.0276
Plasmodium falciparum macrophage migration inhibitory factor 0.0177 0.2521 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0464
Onchocerca volvulus 0.0034 0.0339 0.0239
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0445 0.0611
Toxoplasma gondii hypothetical protein 0.0108 0.146 0.3471
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0149 0.0347
Trypanosoma brucei protein kinase, putative 0.0051 0.0591 0.0531
Brugia malayi hypothetical protein 0.0023 0.0169 0.0232
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0034 0.0338 0.0826
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0424 0.1017
Trypanosoma cruzi ISWI complex protein 0.0017 0.0076 0.0012
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0034 0.0338 0.0826
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0667 1 1
Echinococcus granulosus zinc finger protein 0.0022 0.0148 0.0341
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0321 0.064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.1428 0.3478
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Loa Loa (eye worm) sema domain-containing protein 0.0023 0.0169 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0338 0.0732
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0075 0.0971 0.1333
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0034 0.0338 0.0732
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0338 0.0276
Mycobacterium tuberculosis Conserved hypothetical protein 0.0351 0.5181 1
Brugia malayi hypothetical protein 0.002 0.0119 0.0163
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0262 0.0622
Leishmania major hypothetical protein, conserved 0.0029 0.0262 0.02
Schistosoma mansoni hypothetical protein 0.0034 0.0339 0.0829
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0149 0.0343
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.0773 0.1873
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0338 0.0276
Brugia malayi Sema domain containing protein 0.0023 0.0169 0.0232
Schistosoma mansoni hypothetical protein 0.0023 0.0169 0.0413
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0034 0.0338 0.0806
Loa Loa (eye worm) runx1 0.0061 0.0755 0.1036
Mycobacterium leprae Probable lipase LipE 0.0029 0.0262 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0106 0.0258
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0149 0.0347
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0106 0.0258
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Giardia lamblia PHD finger protein 15 0.0032 0.0309 0.0611
Brugia malayi jmjC domain containing protein 0.0041 0.0445 0.0611
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0034 0.0338 0.0826
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0149 0.0228
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0262 0.0389
Echinococcus granulosus G protein coupled receptor kinase 1 0.0093 0.1234 0.3004
Loa Loa (eye worm) PDE1B protein 0.0034 0.0338 0.0464
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0034 0.0338 0.0826
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0051 0.0591 0.1445
Loa Loa (eye worm) hypothetical protein 0.0489 0.7284 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Loa Loa (eye worm) hypothetical protein 0.0047 0.0537 0.0737
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0262 0.0389
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0149 0.0086
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Plasmodium falciparum phosphodiesterase gamma, putative 0.0034 0.0338 0.1116
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0075 0.0971 0.1333
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0034 0.0338 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0136 0.1895 0.4886
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0177 0.2521 0.3461
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0051 0.0591 0.0531
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0262 0.0642
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0106 0.0237
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0149 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0338 0.0276
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0149 0.0347
Echinococcus granulosus geminin 0.0248 0.3601 0.8805
Brugia malayi Bm-MIF-1, identical 0.0177 0.2521 0.3461
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0502 0.1209
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0591 0.1407
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0276
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0338 0.0276
Plasmodium falciparum thioredoxin reductase 0.0022 0.0149 0.0347
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0591 0.131
Trichomonas vaginalis STE family protein kinase 0.0136 0.1895 0.4886
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0064 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0338 0.0276
Onchocerca volvulus 0.0489 0.7284 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0034 0.0338 0.0276
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0149 0.0086
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0262 0.036
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0667 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0149 0.0167
Brugia malayi PHD-finger family protein 0.0027 0.0238 0.0327
Brugia malayi hypothetical protein 0.0013 0.0012 0.0017
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0149 1
Trypanosoma cruzi ISWI complex protein 0.0017 0.0076 0.0012
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0445 0.1089
Brugia malayi Sema domain containing protein 0.0023 0.0169 0.0232
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0149 0.0212
Loa Loa (eye worm) hypothetical protein 0.0195 0.2793 0.3834
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0034 0.0338 0.0826
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0034 0.0338 0.0464
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0413 0.099
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0034 0.0338 0.0276
Trichomonas vaginalis esterase, putative 0.0029 0.0262 0.0531
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0135 0.1874 0.1822
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0064 0.0203
Schistosoma mansoni hypothetical protein 0.0248 0.3601 0.8808
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0034 0.0338 0.0806
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.1428 0.3478
Echinococcus granulosus protein kinase shaggy 0.0051 0.0591 0.1427
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0136 0.1895 0.1843
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0034 0.0338 0.0464
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0034 0.0338 0.0276
Loa Loa (eye worm) hypothetical protein 0.0042 0.0465 0.0638
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.1116
Onchocerca volvulus 0.0167 0.2365 0.3087
Echinococcus multilocularis zinc finger protein 0.0022 0.0148 0.0341
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0262 0.02
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0034 0.0338 0.0276
Loa Loa (eye worm) hypothetical protein 0.0052 0.0609 0.0836
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0667 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Plasmodium falciparum phosphodiesterase delta, putative 0.0034 0.0338 0.1116
Echinococcus multilocularis caspase 2 0.0034 0.0339 0.0809
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0149 0.0204
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0149 0.0086
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0034 0.0338 0.0276
Plasmodium vivax serine/threonine protein kinase, putative 0.0136 0.1895 0.7452
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0262 0.0642
Onchocerca volvulus Huntingtin homolog 0.0195 0.2793 0.3688
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0034 0.0338 0.0732
Entamoeba histolytica protein kinase, putative 0.0051 0.0591 0.2305
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.028 0.4088 1
Loa Loa (eye worm) sema domain-containing protein 0.0023 0.0169 0.0232
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0149 0.0167
Toxoplasma gondii ABC1 family protein 0.0029 0.0262 0.0494
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0119 0.0056
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0591 0.2305
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0034 0.0338 0.0276
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0321 0.0766
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0149 0.0347
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0034 0.0338 0.0276
Brugia malayi Bromodomain containing protein 0.0042 0.0464 0.0637
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.028 0.4088 1
Onchocerca volvulus 0.0029 0.0262 0.0132
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0262 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0034 0.0338 0.0826
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0824 0.1999
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Trichomonas vaginalis set domain proteins, putative 0.0261 0.3811 1
Echinococcus granulosus plexin a4 0.0065 0.0811 0.1966
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0609 0.1489
Loa Loa (eye worm) hypothetical protein 0.0045 0.0505 0.0693
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0149 0.0228
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0198 0.0464
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0338 0.0732
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0166 0.0228
Brugia malayi glutathione reductase 0.0063 0.0773 0.1061
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Mycobacterium ulcerans lipase LipD 0.0029 0.0262 0.0389
Loa Loa (eye worm) hypothetical protein 0.0195 0.2793 0.3834
Brugia malayi hypothetical protein 0.0195 0.2793 0.3834
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.1116
Loa Loa (eye worm) glutathione reductase 0.0063 0.0773 0.1061
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0119 0.0226
Loa Loa (eye worm) hypothetical protein 0.0032 0.0309 0.0425
Echinococcus granulosus beta-adrenergic receptor kinase 0.0103 0.1396 0.34
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0034 0.0338 0.0276
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0094 0.125 0.1194
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Brugia malayi Plexin repeat family protein 0.0055 0.0657 0.0902
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0034 0.0338 0.0806
Mycobacterium ulcerans beta-lactamase 0.0029 0.0262 0.0389
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0034 0.0338 0.0464
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0149 0.0086
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0262 0.0389
Brugia malayi beta-lactamase 0.0029 0.0262 0.036
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0316 0.4637 0.4603
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0034 0.0338 0.0464
Treponema pallidum NADH oxidase 0.0022 0.0149 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Echinococcus multilocularis Protein lozenge 0.0061 0.0755 0.1828
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0029 0.004
Schistosoma mansoni plexin 0.0032 0.0307 0.075
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Schistosoma mansoni plexin 0.0055 0.0657 0.1608
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0232
Brugia malayi hypothetical protein 0.0023 0.0169 0.0232
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0103 0.1396 0.1916
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0262 0.0531
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0316 0.4637 0.4603
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0338 0.0681
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Brugia malayi Pre-SET motif family protein 0.023 0.3326 0.4566
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.3326 0.4566
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0232
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0061 0.0084
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0034 0.0338 0.0826
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0034 0.0338 0.0464
Loa Loa (eye worm) beta-lactamase 0.0029 0.0262 0.036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0424 0.1017
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0502 0.1209
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Echinococcus multilocularis geminin 0.0248 0.3601 0.8805
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0116 0.0159
Echinococcus granulosus apoptotic protease activating factor 1 0.0034 0.0339 0.0809
Leishmania major hypothetical protein, conserved 0.0034 0.0338 0.0276
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0034 0.0338 0.0464
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0034 0.0338 0.0276
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0034 0.0338 0.1116
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0064 0.0134
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0064 0.0087
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0119 0.0056
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0149 0.0364
Onchocerca volvulus 0.0029 0.0262 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0609 0.1489
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0149 0.0343
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0034 0.0338 0.0276
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0406
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0262 0.02
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0262 0.0389
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0262 0.0389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0149 0.0086
Trypanosoma brucei trypanothione reductase 0.0063 0.0773 0.0714
Loa Loa (eye worm) hypothetical protein 0.0023 0.0169 0.0232
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0094 0.125 0.1194
Onchocerca volvulus 0.0033 0.0321 0.0214
Schistosoma mansoni ap endonuclease 0.0016 0.0064 0.0156
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0034 0.0338 0.0826
Brugia malayi Cell death protein 3 precursor 0.0034 0.0339 0.0465
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0309 0.0611
Trypanosoma brucei eukaryotic translation initiation factor 2-alpha kinase 2 0.0136 0.1895 0.1843
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0303 0.072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0824 0.1999
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0015
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0177 0.2521 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0309 0.0737
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0338 0.0732
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0149 0.0086
Schistosoma mansoni hypothetical protein 0.0248 0.3601 0.8808
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0177 0.2521 0.6557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0321 0.0786
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0732
Giardia lamblia Hypothetical protein 0.0034 0.0338 0.0681
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Brugia malayi Bromodomain containing protein 0.0083 0.1082 0.1486
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0149 0.0167
Echinococcus granulosus semaphorin 1A 0.0023 0.0169 0.0392
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.0338 0.0276
Giardia lamblia Kinase, CMGC GSK 0.0051 0.0591 0.131
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0149 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.0338 0.0732
Plasmodium vivax glycogen synthase kinase 3, putative 0.0051 0.0591 0.2146
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0246 0.3568 0.8726
Loa Loa (eye worm) plexin A 0.0065 0.0811 0.1113
Plasmodium falciparum glycogen synthase kinase 3 0.0051 0.0591 0.2146
Brugia malayi PHD-finger family protein 0.0032 0.0309 0.0425
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.0773 0.1873
Loa Loa (eye worm) hypothetical protein 0.0029 0.0262 0.036

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.799 uM Displacement of [3H]PG2 from human CRTh2 receptor expressed in CHO cells ChEMBL. 17531480
Ki (binding) = 0.799 uM Displacement of [3H]PG2 from human CRTh2 receptor expressed in CHO cells ChEMBL. 17531480
Ki (binding) > 10 uM Binding affinity at prostanoid DP receptor ChEMBL. 17531480
Ki (binding) > 10 uM Binding affinity at prostanoid DP receptor ChEMBL. 17531480

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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