Detailed information for compound 49135

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.9 | Formula: C20H28ClN2O4-
  • H donors: 2 H acceptors: 2 LogP: 3.07 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1noc(c1)/C=C\c1ccccc1OCC(CNC(C)(C)C)O.[Cl-]
  • InChi: 1S/C20H28N2O4.ClH/c1-20(2,3)21-12-17(23)14-25-19-8-6-5-7-15(19)9-10-18-11-16(13-24-4)22-26-18;/h5-11,17,21,23H,12-14H2,1-4H3;1H/p-1/b10-9+;
  • InChiKey: PRQKVEWHVVLBMH-RRABGKBLSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0038 0.0232 0.0526
Trichomonas vaginalis esterase, putative 0.0036 0.0206 0.0461
Loa Loa (eye worm) hypothetical protein 0.0143 0.1247 0.1767
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0003 0.0003
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0144 0.0531
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2121 0.2121
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0181 0.0411
Echinococcus granulosus Solute carrier family 22 5 0.1026 0.9794 0.9794
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0144 0.1842
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0144 0.1842
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.044 0.044
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0268 0.0375
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0181 0.0824
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0038 0.0232 0.0359
Loa Loa (eye worm) hypothetical protein 0.0437 0.4093 0.5796
Brugia malayi Pre-SET motif family protein 0.0412 0.3853 0.5457
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0905 0.3305
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0233 0.0325
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0046 0.0072
Brugia malayi hypothetical protein 0.0437 0.4093 0.5796
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0042 0.0156
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0233 0.1064
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0237 0.2158 1
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0768 0.1083
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0905 0.0905
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0206 0.0206
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0193 0.0299
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0181 0.0256
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0181 0.2324
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0072
Echinococcus multilocularis solute carrier family 22 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus granulosus solute carrier family 22 0.0015 0.0003 0.0003
Loa Loa (eye worm) sugar transporter 0.0015 0.0003 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0323 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0046 0.0046
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0268 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0176 0.0245
Brugia malayi hypothetical protein 0.0015 0.0003 0.0005
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0176 0.226
Leishmania major pyruvate kinase 0.0033 0.0181 0.0252
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0181 0.0404
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0206 0.0461
Loa Loa (eye worm) beta-lactamase 0.0036 0.0206 0.0292
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0176
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0905 0.205
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0768 0.3547
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0905 0.1278
Plasmodium vivax glutathione reductase, putative 0.0094 0.0768 1
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0065
Schistosoma mansoni sugar transporter 0.0015 0.0003 0.0005
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0279 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Mycobacterium tuberculosis Probable oxidoreductase 0.0237 0.2158 1
Onchocerca volvulus 0.0015 0.0003 0.0007
Brugia malayi Bromodomain containing protein 0.0034 0.0193 0.0273
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0176 0.0245
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0176 0.0696
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0046 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1382 0.6398
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0245
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0046 0.0065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1227 0.1735
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0144 0.0391
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.044 0.5715
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0176 0.0249
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1048 1 1
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Schistosoma mansoni glucose transport protein 0.0015 0.0003 0.0005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0237 0.2158 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2747 0.3887
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0942
Plasmodium falciparum thioredoxin reductase 0.0094 0.0768 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0206 0.2654
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0493 0.1726
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0176 0.226
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0233 0.073
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0696
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0279 0.0395
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0042 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0503 0.0713
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0505
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0233 0.0329
Echinococcus multilocularis pyruvate kinase 0.0017 0.0026 0.0026
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.6453 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0279 0.0432
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Leishmania major hypothetical protein, conserved 0.0036 0.0206 0.0287
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0181 0.0252
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0046 0.0046
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0484 0.0681
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0233 0.0233
Brugia malayi glutathione reductase 0.0094 0.0768 0.1087
Brugia malayi CXXC zinc finger family protein 0.0063 0.0472 0.0669
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0046 0.0046
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.1247 0.1767
Brugia malayi glutaminase DH11.1 0.0271 0.2485 0.352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.1889 0.2675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0322 0.0322
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0493 0.0493
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0206 0.0942
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0905 0.0905
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.0945 0.0945
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.3853 0.5457
Echinococcus granulosus microtubule associated protein 2 0.0681 0.6453 0.6453
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0046 0.0046
Echinococcus granulosus dna polymerase eta 0.0064 0.0477 0.0477
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1226 0.4926
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0233 0.0329
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0322 0.0322
Mycobacterium ulcerans glutaminase 0.0271 0.2485 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0206 0.0817
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.044 0.0682
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0046 0.0046
Mycobacterium ulcerans hypothetical protein 0.0036 0.0206 0.0817
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0768 0.0768
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus granulosus peregrin 0.0034 0.0193 0.0193
Schistosoma mansoni glutaminase 0.0271 0.2485 0.3851
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0905 0.3634
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0176 0.0245
Schistosoma mansoni hypothetical protein 0.0066 0.0503 0.078
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0222 0.2857
Trichomonas vaginalis set domain proteins, putative 0.0469 0.4404 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0181 0.0256
Echinococcus granulosus pyruvate kinase 0.0033 0.0181 0.0181
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1226 0.5286
Schistosoma mansoni hypothetical protein 0.0143 0.1247 0.1933
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0206 0.0319
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2747 0.3887
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.1216 0.1722
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.1216 0.1722
Loa Loa (eye worm) glutaminase 0.0271 0.2485 0.352
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0768 0.0768
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0206 0.0287
Loa Loa (eye worm) runx1 0.0055 0.0393 0.0556
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0181 0.0256
Loa Loa (eye worm) hypothetical protein 0.0038 0.0232 0.0328
Leishmania major trypanothione reductase 0.0094 0.0768 0.1083
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0206 0.0942
Brugia malayi jmjC domain containing protein 0.0112 0.0945 0.1338
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0493 0.0698
Echinococcus multilocularis dna polymerase eta 0.0064 0.0477 0.0477
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0093 0.0131
Echinococcus granulosus cpg binding protein 0.0065 0.0489 0.0489
Onchocerca volvulus 0.0015 0.0003 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.044 0.0682
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.044 0.0682
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0233 0.036
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0227 0.0227
Giardia lamblia Pyruvate kinase 0.0017 0.0026 0.0085
Plasmodium falciparum glutathione reductase 0.0094 0.0768 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0206 0.0206
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0206 0.0287
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0674 0.8778
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0484 0.1937
Brugia malayi MH2 domain containing protein 0.014 0.1216 0.1722
Schistosoma mansoni sugar transporter 0.0015 0.0003 0.0005
Trypanosoma brucei unspecified product 0.0038 0.0233 0.0325
Brugia malayi 6-phosphofructokinase 0.0108 0.0905 0.1282
Brugia malayi hypothetical protein 0.0015 0.0003 0.0005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0176
Echinococcus granulosus dna polymerase kappa 0.0038 0.0233 0.0233
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0003 0.0005
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0176 0.0393
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0063 0.0098
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0744 0.7061 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0084 0.012
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1226 0.5675
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0233 0.1064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0046 0.0046
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0046 0.0065
Echinococcus multilocularis pyruvate kinase 0.0017 0.0026 0.0026
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0046 0.0072
Schistosoma mansoni hypothetical protein 0.0066 0.0503 0.078
Loa Loa (eye worm) hypothetical protein 0.0437 0.4093 0.5796
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0046 0.0065
Leishmania major DNA polymerase eta, putative 0.0064 0.0477 0.0671
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.0052 0.0052
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.1889 0.2675
Schistosoma mansoni cpg binding protein 0.0065 0.0489 0.0757
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0213 0.1927 0.893
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0493 0.0694
Brugia malayi beta-lactamase 0.0036 0.0206 0.0292
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0088
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0181 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0046 0.0046
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0484 0.0484
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0176 0.226
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0046 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0545 0.0771
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.0052 0.0052
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0268 0.0375
Leishmania major C-8 sterol isomerase-like protein 0.0744 0.7061 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0072
Echinococcus granulosus solute carrier family 22 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0744 0.7061 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0144 0.1842
Trypanosoma brucei unspecified product 0.0026 0.0118 0.0162
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2654 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0042 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Echinococcus multilocularis solute carrier family 22 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0213 0.1927 0.893
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0181 0.0256
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0193 0.248
Trypanosoma brucei trypanothione reductase 0.0094 0.0768 0.1083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0206 0.0292
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0905 0.3664
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0176 1
Mycobacterium tuberculosis Probable reductase 0.0213 0.1927 0.893
Toxoplasma gondii exonuclease III APE 0.0019 0.0042 0.0505
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0181 0.2324
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.2747 0.3887
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0477 0.0671
Brugia malayi Muscleblind-like protein 0.0147 0.1289 0.1825
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.0052 0.0635
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0905 0.4186
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0461
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.2747 0.3887
Giardia lamblia Pyruvate kinase 0.0033 0.0181 0.067
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0181 0.0411
Schistosoma mansoni glucose transporter 0.0015 0.0003 0.0005
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0003 0.0005
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0084 0.0163
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0046 0.0065
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0942
Onchocerca volvulus 0.0437 0.4093 0.9294
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0322 0.0455
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0046 0.0046
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0026 0.0295
Onchocerca volvulus 0.0036 0.0206 0.0468
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0461
Echinococcus granulosus muscleblind protein 0.0147 0.1289 0.1289
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.2654 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0046 0.0046
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0003 0.0005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0493 0.0694
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0176 0.226
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0233 0.2121 0.3004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0233 0.0521
Echinococcus granulosus solute carrier family 22 0.0015 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0055
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0093 0.0131
Onchocerca volvulus 0.0015 0.0003 0.0007
Schistosoma mansoni cpg binding protein 0.0065 0.0489 0.0757
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0262 0.0262
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0003 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0193 0.248
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0373 0.0529
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0176 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0484 0.2232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0322 0.0455
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0144 0.1842
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0505
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0905 0.1282
Mycobacterium ulcerans lipase LipD 0.0036 0.0206 0.0817
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1289 0.1289
Onchocerca volvulus 0.006 0.044 0.0999
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trypanosoma brucei C-8 sterol isomerase, putative 0.0744 0.7061 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0181 0.0252
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0273
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0233 0.0233
Onchocerca volvulus 0.0015 0.0003 0.0007
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0905 0.3305
Echinococcus granulosus pyruvate kinase 0.0017 0.0026 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0042 0.0059
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0477 0.0671
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Schistosoma mansoni glucose transport protein 0.0015 0.0003 0.0005
Brugia malayi Thioredoxin reductase 0.0094 0.0768 0.1087
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0003 0.0003
Chlamydia trachomatis pyruvate kinase 0.0033 0.0181 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0213 0.1927 0.8834
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0213 0.1927 0.893
Plasmodium vivax SET domain protein, putative 0.006 0.044 0.5715
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0206 0.0128
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0088
Echinococcus multilocularis solute carrier family 22 0.0015 0.0003 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0503 0.0503
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0905 0.205
Schistosoma mansoni hypothetical protein 0.0066 0.0503 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0118 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0477 0.0676
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.1889 0.2675
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Onchocerca volvulus 0.0015 0.0003 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0118 0.0162
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0905 0.1278
Schistosoma mansoni pyruvate kinase 0.0017 0.0026 0.004
Brugia malayi hypothetical protein 0.0019 0.0046 0.0065
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0042 0.2237
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0046 0.0046
Onchocerca volvulus 0.0015 0.0003 0.0007
Onchocerca volvulus Putative transporter 0.0015 0.0003 0.0007
Brugia malayi jmjC domain containing protein 0.0043 0.0279 0.0395
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0206 0.2654
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0176 0.0393
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0905 0.3305
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0227 0.0227
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2654 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0206 0.0942
Brugia malayi hypothetical protein 0.0233 0.2121 0.3004
Echinococcus granulosus disco interacting protein 2 0.0038 0.0232 0.0232
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0206 0.0942
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0206 0.0942
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0744 0.7061 1
Toxoplasma gondii hypothetical protein 0.0048 0.0327 0.4242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Loa Loa (eye worm) hypothetical protein 0.0209 0.1889 0.2675
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0493 0.0698
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0046 0.0065
Brugia malayi Sugar transporter family protein 0.0015 0.0003 0.0005
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0016
Mycobacterium ulcerans hypothetical protein 0.0157 0.1382 0.5554
Onchocerca volvulus 0.0469 0.4404 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0144 0.032
Giardia lamblia PHD finger protein 15 0.0034 0.0193 0.0715
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0046 0.0065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0905 0.1403
Onchocerca volvulus 0.0048 0.0323 0.0733
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0046 0.0065
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0055
Plasmodium falciparum thioredoxin reductase 0.0032 0.0176 0.226
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0034 0.0193 0.0299
Echinococcus multilocularis pyruvate kinase 0.0017 0.0026 0.0026
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0503 0.0713
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0768 0.1087
Loa Loa (eye worm) hypothetical protein 0.0059 0.0429 0.0607
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0176 0.0245
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2121 0.2121
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0484 0.0484
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0279 0.0432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0322 0.0498
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus multilocularis solute carrier family 22 0.0015 0.0003 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0905 0.3305
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0503 0.0503
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0042 0.0146
Brugia malayi major facilitator superfamily protein 0.0015 0.0003 0.0005
Schistosoma mansoni survival motor neuron protein 0.0048 0.0323 0.05
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.0232 0.0328
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0503 0.0503
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0046 0.0098
Schistosoma mansoni pyruvate kinase 0.0033 0.0181 0.028
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Onchocerca volvulus 0.0036 0.0206 0.0468
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0905 0.1278
Brugia malayi beta-lactamase family protein 0.0036 0.0206 0.0292
Echinococcus multilocularis Protein lozenge 0.0055 0.0393 0.0393
Leishmania major modification methylase-like protein 0.002 0.0052 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Trichomonas vaginalis glutaminase, putative 0.0271 0.2485 0.564
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0026 0.0295
Brugia malayi 6-phosphofructokinase 0.0108 0.0905 0.1282
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0193 0.0273
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0046 0.0072
Schistosoma mansoni hypothetical protein 0.0066 0.0503 0.078
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0206 0.0461
Echinococcus granulosus pyruvate kinase 0.0017 0.0026 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0472 0.0669
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Loa Loa (eye worm) sugar transporter 0.0015 0.0003 0.0005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0176 0.0802
Brugia malayi hypothetical protein 0.0019 0.0046 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0046 0.0046
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0233 0.0325
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0503 0.0713
Loa Loa (eye worm) hypothetical protein 0.0147 0.1289 0.1825
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0042 0.0055
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0484 0.0686
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0046 0.0065
Echinococcus multilocularis expressed protein 0.037 0.3444 0.3444
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0181 0.0256
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.012
Brugia malayi PHD-finger family protein 0.0034 0.0193 0.0273
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0233 0.0924
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0233 0.0521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0322 0.0322
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0015 0.0003 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0905 0.205
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0905 0.1403
Onchocerca volvulus 0.0063 0.0472 0.1072
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0322 0.0322
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0046 0.0046
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.0052 0.008
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0026 0.0295
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0176 0.0245
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0176 0.226
Brugia malayi hypothetical protein 0.0015 0.0003 0.0005
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0193 0.0193
Brugia malayi Pre-SET motif family protein 0.006 0.044 0.0623
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.044 0.044
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0144 0.1842
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0046 0.0046
Echinococcus granulosus expressed protein 0.037 0.3444 0.3444
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0046 0.0072
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0176 0.0696
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0222 0.0309
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0046 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0245
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0768 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Mycobacterium tuberculosis Probable dehydrogenase 0.0213 0.1927 0.893
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1227 0.1735
Brugia malayi phosphofructokinase 0.0108 0.0905 0.1282
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Loa Loa (eye worm) glutathione reductase 0.0094 0.0768 0.1087
Giardia lamblia DINP protein human, muc B family 0.0038 0.0233 0.0865
Toxoplasma gondii hypothetical protein 0.0084 0.0674 0.8778
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0042 0.0055
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.0945 0.0945
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0942
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0206 0.0817
Mycobacterium ulcerans beta-lactamase 0.0036 0.0206 0.0817
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0206 0.0287
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0046 0.0065
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2059 0.9543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0181 0.0404
Schistosoma mansoni sugar transporter 0.0015 0.0003 0.0005
Leishmania major DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0118 0.0162
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0003 0.0005
Leishmania major pyruvate kinase 0.0033 0.0181 0.0252
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0233 0.0233
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.0052 0.0635
Brugia malayi PXA domain containing protein 0.0019 0.0046 0.0065
Plasmodium falciparum glutathione reductase 0.0032 0.0176 0.226
Schistosoma mansoni DNA polymerase eta 0.0064 0.0477 0.0739
Echinococcus multilocularis disco interacting protein 2 0.0038 0.0232 0.0232
Echinococcus multilocularis pyruvate kinase 0.0026 0.0114 0.0114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0357 0.0501
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0193 0.0193
Brugia malayi PXA domain containing protein 0.0019 0.0046 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.044 0.0682
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0046 0.0046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0484 0.1937
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0484 0.075
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.2654 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Brugia malayi Sugar transporter family protein 0.0015 0.0003 0.0005
Onchocerca volvulus Alhambra homolog 0.0034 0.0193 0.0438
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0181 0.0252
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0063 0.0472 0.0732
Toxoplasma gondii thioredoxin reductase 0.0094 0.0768 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0233 0.0325
Treponema pallidum NADH oxidase 0.0032 0.0176 0.0513
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.043 0.5579
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus multilocularis peregrin 0.0034 0.0193 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0322 0.0498
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0144 0.1842
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0206 0.0942
Brugia malayi major facilitator superfamily protein 0.0015 0.0003 0.0005
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0176 0.0245
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0206 0.0319
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0176 0.0652
Plasmodium falciparum pyruvate kinase 0.0033 0.0181 0.2324
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0273
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0905 0.1282
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0144 0.1842
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0144 0.0391
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0722 0.1119
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Plasmodium falciparum phd finger protein, putative 0.0034 0.0193 0.248
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0905 0.1282
Schistosoma mansoni lozenge 0.0055 0.0393 0.0609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0064 0.0477 0.0676
Onchocerca volvulus 0.0036 0.0206 0.0468
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0495 0.0767
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.0052 0.0635
Onchocerca volvulus 0.0015 0.0003 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0079 0.0112
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0193 0.248
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0181 0.0716
Echinococcus multilocularis GPCR, family 2 0.0066 0.0503 0.0503
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.6453 0.6453
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0176 0.226
Echinococcus granulosus pyruvate kinase 0.0017 0.0026 0.0026
Trypanosoma brucei unspecified product 0.0026 0.0118 0.0162
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0268 0.0375
Echinococcus granulosus pyruvate kinase 0.0033 0.0181 0.0181
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0206 0.0942
Onchocerca volvulus 0.0015 0.0003 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0461
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0493 0.0694
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0046 0.0065
Loa Loa (eye worm) hypothetical protein 0.038 0.3542 0.5016
Brugia malayi Sugar transporter family protein 0.0015 0.0003 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0322 0.0322
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0042 0.0179
Schistosoma mansoni glucose transport protein 0.0015 0.0003 0.0005
Echinococcus granulosus GPCR family 2 0.0066 0.0503 0.0503
Schistosoma mansoni sugar transporter 0.0015 0.0003 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0042 0.0059
Schistosoma mansoni hypothetical protein 0.0048 0.0323 0.05
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0905 0.205
Brugia malayi beta-lactamase family protein 0.0036 0.0206 0.0292
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0176 0.8672
Loa Loa (eye worm) hypothetical protein 0.006 0.044 0.0623
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0493 0.0694
Schistosoma mansoni pyruvate kinase 0.0033 0.0181 0.028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0233 0.036
Echinococcus granulosus solute carrier family 22 0.0015 0.0003 0.0003
Mycobacterium leprae Probable lipase LipE 0.0036 0.0206 0.0128
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0003 0.0003
Echinococcus multilocularis pyruvate kinase 0.0033 0.0181 0.0181
Loa Loa (eye worm) glutaminase 2 0.0271 0.2485 0.352
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1227 0.1735
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0493 0.0493
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0046 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0233 0.0924
Leishmania major DNA polymerase eta, putative 0.0037 0.0222 0.0309
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0503 0.0503
Onchocerca volvulus 0.0015 0.0003 0.0007
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.0052 0.0038
Echinococcus multilocularis muscleblind protein 0.0147 0.1289 0.1289
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.0052 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus multilocularis cpg binding protein 0.0065 0.0489 0.0489
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0213 0.1927 0.893
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0206 0.0292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0237 0.2158 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0066 0.0503 0.0713
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0046 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0176 0.0245
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0233 0.0325
Loa Loa (eye worm) hypothetical protein 0.0147 0.1289 0.1825
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0181 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0322 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.0052 0.0635
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0493 0.0764
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005

Activities

Activity type Activity value Assay description Source Reference
ED20 (functional) ~ 0.8 mg kg-1 Dose required for hypotensive activity in anesthetized rat after intravenous administration ChEMBL. 6118439
ED20 (functional) ~ 21.5 mg kg-1 Dose required for antihypertensive activity in spontaneous hypertensive rats after oral administration ChEMBL. 6118439
ED50 (functional) = 0.0074 mg kg-1 Dose required for inhibition of isoproterenol-induced tachycardia in pithed rat after intravenous administration ChEMBL. 6118439
ED50 (functional) = 0.21 mg kg-1 Dose required for inhibition of L-phenylephrine-induced pressor response in pithed rats after intravenous administration ChEMBL. 6118439
Relative potency (functional) ~ 2.2 Relative potency required for antihypertensive activity in spontaneous hypertensive rats after oral administration ChEMBL. 6118439
Relative potency (functional) = 2.2 Relative potency required for inhibition of L-phenylephrine-induced pressor response in pithed rats ChEMBL. 6118439
Relative potency (functional) ~ 6.5 Relative potency required for hypotensive activity in anesthetized rat ChEMBL. 6118439
Relative potency (functional) = 18.9 Relative potency required for inhibition of isoproterenol-induced tachycardia in pithed rat after intravenous administration ChEMBL. 6118439

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.