Detailed information for compound 49240

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 381.874 | Formula: C19H26ClN2O4-
  • H donors: 2 H acceptors: 2 LogP: 2.88 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1noc(c1)/C=C\c1ccccc1OCC(CNC(C)C)O.[Cl-]
  • InChi: 1S/C19H26N2O4.ClH/c1-14(2)20-11-17(22)13-24-19-7-5-4-6-15(19)8-9-18-10-16(12-23-3)21-25-18;/h4-10,14,17,20,22H,11-13H2,1-3H3;1H/p-1/b9-8+;
  • InChiKey: UADXRNLPRRCQEI-HRNDJLQDSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0046 0.0065
Echinococcus multilocularis expressed protein 0.037 0.3444 0.3444
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0181 0.0256
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0484 0.0686
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.012
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0233 0.0521
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0233 0.0924
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0322 0.0322
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0015 0.0003 0.0003
Brugia malayi PHD-finger family protein 0.0034 0.0193 0.0273
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0905 0.205
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0233 0.0325
Loa Loa (eye worm) hypothetical protein 0.0147 0.1289 0.1825
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0042 0.0055
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0503 0.0713
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0176 0.0802
Loa Loa (eye worm) sugar transporter 0.0015 0.0003 0.0005
Brugia malayi hypothetical protein 0.0019 0.0046 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0046 0.0046
Echinococcus granulosus pyruvate kinase 0.0017 0.0026 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0472 0.0669
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0144 0.1842
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0046 0.0046
Echinococcus granulosus expressed protein 0.037 0.3444 0.3444
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0046 0.0072
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0176 0.0696
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Brugia malayi hypothetical protein 0.0015 0.0003 0.0005
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0193 0.0193
Brugia malayi Pre-SET motif family protein 0.006 0.044 0.0623
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.044 0.044
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0176 0.0245
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0176 0.226
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0905 0.1403
Onchocerca volvulus 0.0063 0.0472 0.1072
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.0052 0.008
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0046 0.0046
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0322 0.0322
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0026 0.0295
Brugia malayi major facilitator superfamily protein 0.0015 0.0003 0.0005
Schistosoma mansoni survival motor neuron protein 0.0048 0.0323 0.05
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.0232 0.0328
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0046 0.0098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0503 0.0503
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0905 0.3305
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0503 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0042 0.0146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0322 0.0498
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus multilocularis solute carrier family 22 0.0015 0.0003 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0503 0.0713
Echinococcus multilocularis pyruvate kinase 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0059 0.0429 0.0607
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.0768 0.1087
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0176 0.0245
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2121 0.2121
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0484 0.0484
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0279 0.0432
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0046 0.0072
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0206 0.0461
Schistosoma mansoni hypothetical protein 0.0066 0.0503 0.078
Leishmania major modification methylase-like protein 0.002 0.0052 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Trichomonas vaginalis glutaminase, putative 0.0271 0.2485 0.564
Brugia malayi 6-phosphofructokinase 0.0108 0.0905 0.1282
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0026 0.0295
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0193 0.0273
Onchocerca volvulus 0.0036 0.0206 0.0468
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0905 0.1278
Brugia malayi beta-lactamase family protein 0.0036 0.0206 0.0292
Echinococcus multilocularis Protein lozenge 0.0055 0.0393 0.0393
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0046 0.0072
Schistosoma mansoni pyruvate kinase 0.0033 0.0181 0.028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0206 0.0942
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0744 0.7061 1
Toxoplasma gondii hypothetical protein 0.0048 0.0327 0.4242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Loa Loa (eye worm) hypothetical protein 0.0209 0.1889 0.2675
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0227 0.0227
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0206 0.0942
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2654 1
Brugia malayi hypothetical protein 0.0233 0.2121 0.3004
Echinococcus granulosus disco interacting protein 2 0.0038 0.0232 0.0232
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0206 0.0942
Brugia malayi jmjC domain containing protein 0.0043 0.0279 0.0395
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0206 0.2654
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0176 0.0393
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0905 0.3305
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0118 0.0162
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0905 0.1278
Schistosoma mansoni pyruvate kinase 0.0017 0.0026 0.004
Brugia malayi hypothetical protein 0.0019 0.0046 0.0065
Onchocerca volvulus 0.0015 0.0003 0.0007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0042 0.2237
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0046 0.0046
Onchocerca volvulus Putative transporter 0.0015 0.0003 0.0007
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0046 0.0065
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0055
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0046 0.0046
Plasmodium falciparum thioredoxin reductase 0.0032 0.0176 0.226
Schistosoma mansoni hypothetical protein 0.0034 0.0193 0.0299
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0046 0.0065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0905 0.1403
Onchocerca volvulus 0.0048 0.0323 0.0733
Mycobacterium ulcerans hypothetical protein 0.0157 0.1382 0.5554
Onchocerca volvulus 0.0469 0.4404 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0144 0.032
Giardia lamblia PHD finger protein 15 0.0034 0.0193 0.0715
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0493 0.0698
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0046 0.0065
Brugia malayi Sugar transporter family protein 0.0015 0.0003 0.0005
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0016
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0042 0.0059
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0477 0.0671
Schistosoma mansoni glucose transport protein 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0181 0.0252
Trypanosoma brucei C-8 sterol isomerase, putative 0.0744 0.7061 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0273
Onchocerca volvulus 0.0015 0.0003 0.0007
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0233 0.0233
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0905 0.3305
Echinococcus granulosus pyruvate kinase 0.0017 0.0026 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Onchocerca volvulus 0.006 0.044 0.0999
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Mycobacterium ulcerans lipase LipD 0.0036 0.0206 0.0817
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1289 0.1289
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0477 0.0676
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.1889 0.2675
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Onchocerca volvulus 0.0015 0.0003 0.0007
Schistosoma mansoni hypothetical protein 0.0066 0.0503 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0118 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0206 0.0128
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0088
Echinococcus multilocularis solute carrier family 22 0.0015 0.0003 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0503 0.0503
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0905 0.205
Brugia malayi Thioredoxin reductase 0.0094 0.0768 0.1087
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0003 0.0003
Chlamydia trachomatis pyruvate kinase 0.0033 0.0181 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0213 0.1927 0.893
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0213 0.1927 0.8834
Plasmodium vivax SET domain protein, putative 0.006 0.044 0.5715
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0503 0.0503
Onchocerca volvulus 0.0015 0.0003 0.0007
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.0052 0.0038
Echinococcus multilocularis muscleblind protein 0.0147 0.1289 0.1289
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.0052 0.0069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0233 0.0924
Leishmania major DNA polymerase eta, putative 0.0037 0.0222 0.0309
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0046 0.0046
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0493 0.0493
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1227 0.1735
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.0052 0.0635
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0493 0.0764
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0233 0.0325
Loa Loa (eye worm) hypothetical protein 0.0147 0.1289 0.1825
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0181 0.0252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0322 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0046 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0176 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus multilocularis cpg binding protein 0.0065 0.0489 0.0489
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0213 0.1927 0.893
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0237 0.2158 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0206 0.0292
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0066 0.0503 0.0713
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0461
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0493 0.0694
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0046 0.0065
Onchocerca volvulus 0.0015 0.0003 0.0007
Trypanosoma brucei unspecified product 0.0026 0.0118 0.0162
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0268 0.0375
Echinococcus granulosus pyruvate kinase 0.0033 0.0181 0.0181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0206 0.0942
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0079 0.0112
Echinococcus multilocularis GPCR, family 2 0.0066 0.0503 0.0503
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0181 0.0716
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0193 0.248
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.6453 0.6453
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0176 0.226
Echinococcus granulosus pyruvate kinase 0.0017 0.0026 0.0026
Mycobacterium leprae Probable lipase LipE 0.0036 0.0206 0.0128
Echinococcus granulosus solute carrier family 22 0.0015 0.0003 0.0003
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0003 0.0003
Loa Loa (eye worm) glutaminase 2 0.0271 0.2485 0.352
Echinococcus multilocularis pyruvate kinase 0.0033 0.0181 0.0181
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0176 0.8672
Brugia malayi beta-lactamase family protein 0.0036 0.0206 0.0292
Loa Loa (eye worm) hypothetical protein 0.006 0.044 0.0623
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0493 0.0694
Schistosoma mansoni pyruvate kinase 0.0033 0.0181 0.028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0233 0.036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0322 0.0322
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0042 0.0179
Schistosoma mansoni glucose transport protein 0.0015 0.0003 0.0005
Echinococcus granulosus GPCR family 2 0.0066 0.0503 0.0503
Schistosoma mansoni sugar transporter 0.0015 0.0003 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0042 0.0059
Schistosoma mansoni hypothetical protein 0.0048 0.0323 0.05
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0905 0.205
Loa Loa (eye worm) hypothetical protein 0.038 0.3542 0.5016
Brugia malayi Sugar transporter family protein 0.0015 0.0003 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Brugia malayi major facilitator superfamily protein 0.0015 0.0003 0.0005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0206 0.0942
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus multilocularis peregrin 0.0034 0.0193 0.0193
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0144 0.1842
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0322 0.0498
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Onchocerca volvulus Alhambra homolog 0.0034 0.0193 0.0438
Brugia malayi Sugar transporter family protein 0.0015 0.0003 0.0005
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0181 0.0252
Schistosoma mansoni cpg binding protein 0.0063 0.0472 0.0732
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0233 0.0325
Treponema pallidum NADH oxidase 0.0032 0.0176 0.0513
Toxoplasma gondii thioredoxin reductase 0.0094 0.0768 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.043 0.5579
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0046 0.0046
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0484 0.1937
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0484 0.075
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.2654 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0064 0.0477 0.0676
Onchocerca volvulus 0.0036 0.0206 0.0468
Onchocerca volvulus 0.0015 0.0003 0.0007
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.0052 0.0635
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0495 0.0767
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0144 0.0391
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0722 0.1119
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Plasmodium falciparum phd finger protein, putative 0.0034 0.0193 0.248
Schistosoma mansoni lozenge 0.0055 0.0393 0.0609
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0905 0.1282
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0905 0.1282
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0144 0.1842
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0206 0.0319
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0176 0.0245
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0176 0.0652
Plasmodium falciparum pyruvate kinase 0.0033 0.0181 0.2324
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0273
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0206 0.0287
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0046 0.0065
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2059 0.9543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.0945 0.0945
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0942
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0042 0.0055
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0206 0.0817
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Mycobacterium ulcerans beta-lactamase 0.0036 0.0206 0.0817
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Brugia malayi phosphofructokinase 0.0108 0.0905 0.1282
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0003 0.0003
Loa Loa (eye worm) glutathione reductase 0.0094 0.0768 0.1087
Giardia lamblia DINP protein human, muc B family 0.0038 0.0233 0.0865
Toxoplasma gondii hypothetical protein 0.0084 0.0674 0.8778
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0222 0.0309
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0046 0.0046
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.0768 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0245
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Mycobacterium tuberculosis Probable dehydrogenase 0.0213 0.1927 0.893
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1227 0.1735
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0118 0.0162
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0003 0.0005
Leishmania major pyruvate kinase 0.0033 0.0181 0.0252
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.0052 0.0635
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0233 0.0233
Brugia malayi PXA domain containing protein 0.0019 0.0046 0.0065
Plasmodium falciparum glutathione reductase 0.0032 0.0176 0.226
Echinococcus multilocularis pyruvate kinase 0.0026 0.0114 0.0114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0357 0.0501
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0193 0.0193
Echinococcus multilocularis disco interacting protein 2 0.0038 0.0232 0.0232
Schistosoma mansoni DNA polymerase eta 0.0064 0.0477 0.0739
Brugia malayi PXA domain containing protein 0.0019 0.0046 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.044 0.0682
Leishmania major DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0181 0.0404
Schistosoma mansoni sugar transporter 0.0015 0.0003 0.0005
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.1889 0.2675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0322 0.0322
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0493 0.0493
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0206 0.0942
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.1247 0.1767
Brugia malayi glutaminase DH11.1 0.0271 0.2485 0.352
Brugia malayi glutathione reductase 0.0094 0.0768 0.1087
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0046 0.0046
Brugia malayi CXXC zinc finger family protein 0.0063 0.0472 0.0669
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0181 0.0252
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0046 0.0046
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0484 0.0681
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0233 0.0233
Echinococcus granulosus peregrin 0.0034 0.0193 0.0193
Schistosoma mansoni glutaminase 0.0271 0.2485 0.3851
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0905 0.3634
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0176 0.0245
Schistosoma mansoni hypothetical protein 0.0066 0.0503 0.078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0322 0.0322
Mycobacterium ulcerans glutaminase 0.0271 0.2485 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0206 0.0817
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0233 0.0329
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.044 0.0682
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0046 0.0046
Mycobacterium ulcerans hypothetical protein 0.0036 0.0206 0.0817
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0768 0.0768
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus granulosus dna polymerase eta 0.0064 0.0477 0.0477
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1226 0.4926
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0905 0.0905
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.0945 0.0945
Echinococcus granulosus microtubule associated protein 2 0.0681 0.6453 0.6453
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.3853 0.5457
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0046 0.0046
Toxoplasma gondii ABC1 family protein 0.0036 0.0206 0.2654
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0493 0.1726
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0176 0.226
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0233 0.073
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0696
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2747 0.3887
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Plasmodium falciparum thioredoxin reductase 0.0094 0.0768 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0942
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Schistosoma mansoni glucose transport protein 0.0015 0.0003 0.0005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0237 0.2158 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0181 0.0181
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1227 0.1735
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0046 0.0065
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0144 0.0391
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.044 0.5715
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0176 0.0249
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1048 1 1
Onchocerca volvulus 0.0015 0.0003 0.0007
Entamoeba histolytica hypothetical protein 0.0019 0.0046 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Leishmania major hypothetical protein, conserved 0.0036 0.0206 0.0287
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0233 0.0329
Echinococcus multilocularis pyruvate kinase 0.0017 0.0026 0.0026
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.6453 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0279 0.0432
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0505
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0233 0.0325
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0279 0.0395
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0042 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0503 0.0713
Leishmania major pyruvate kinase 0.0033 0.0181 0.0252
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0181 0.0404
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0206 0.0461
Loa Loa (eye worm) beta-lactamase 0.0036 0.0206 0.0292
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0176
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0176 0.0245
Brugia malayi hypothetical protein 0.0015 0.0003 0.0005
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0176 0.226
Loa Loa (eye worm) sugar transporter 0.0015 0.0003 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0323 0.0457
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0268 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0072
Echinococcus multilocularis solute carrier family 22 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Echinococcus granulosus solute carrier family 22 0.0015 0.0003 0.0003
Onchocerca volvulus 0.0015 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0046 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1382 0.6398
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0245
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0176 0.0245
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0176 0.0696
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0065
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0279 0.0279
Schistosoma mansoni sugar transporter 0.0015 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Onchocerca volvulus 0.0015 0.0003 0.0007
Mycobacterium tuberculosis Probable oxidoreductase 0.0237 0.2158 1
Brugia malayi Bromodomain containing protein 0.0034 0.0193 0.0273
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0905 0.205
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0905 0.1278
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.0768 0.3547
Plasmodium vivax glutathione reductase, putative 0.0094 0.0768 1
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0144 0.1842
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0268 0.0375
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.044 0.044
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0181 0.0824
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0038 0.0232 0.0359
Loa Loa (eye worm) hypothetical protein 0.0437 0.4093 0.5796
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0144 0.1842
Loa Loa (eye worm) hypothetical protein 0.0143 0.1247 0.1767
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0003 0.0003
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0144 0.0531
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0181 0.0411
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2121 0.2121
Echinococcus granulosus Solute carrier family 22 5 0.1026 0.9794 0.9794
Onchocerca volvulus 0.0038 0.0232 0.0526
Trichomonas vaginalis esterase, putative 0.0036 0.0206 0.0461
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0206 0.0206
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0193 0.0299
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0181 0.0256
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0181 0.2324
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0768 0.1083
Onchocerca volvulus 0.0015 0.0003 0.0007
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0905 0.0905
Brugia malayi hypothetical protein 0.0437 0.4093 0.5796
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0042 0.0156
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0046 0.0072
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0237 0.2158 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0233 0.1064
Brugia malayi Pre-SET motif family protein 0.0412 0.3853 0.5457
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0905 0.3305
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0233 0.0325
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0046 0.0046
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0003 0.0005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0493 0.0694
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0176 0.226
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0072
Onchocerca volvulus 0.0036 0.0206 0.0468
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0461
Echinococcus granulosus muscleblind protein 0.0147 0.1289 0.1289
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.2654 1
Onchocerca volvulus 0.0437 0.4093 0.9294
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0322 0.0455
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0046 0.0046
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0026 0.0295
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0176 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0484 0.2232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0322 0.0455
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0144 0.1842
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0505
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0905 0.1282
Schistosoma mansoni cpg binding protein 0.0065 0.0489 0.0757
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0003 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0262 0.0262
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0193 0.248
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0098
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0373 0.0529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0055
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0093 0.0131
Onchocerca volvulus 0.0015 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0233 0.2121 0.3004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0233 0.0521
Echinococcus granulosus solute carrier family 22 0.0015 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2654 0.6023
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0144 0.032
Echinococcus multilocularis solute carrier family 22 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0213 0.1927 0.893
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0181 0.0256
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0193 0.248
Trypanosoma brucei trypanothione reductase 0.0094 0.0768 0.1083
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0144 0.1842
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2654 1
Trypanosoma brucei unspecified product 0.0026 0.0118 0.0162
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0042 0.0042
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.0052 0.0052
Leishmania major C-8 sterol isomerase-like protein 0.0744 0.7061 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0268 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0744 0.7061 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0003 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0545 0.0771
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0003 0.0005
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0084 0.0163
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0046 0.0065
Mycobacterium tuberculosis Conserved protein 0.0036 0.0206 0.0942
Giardia lamblia Pyruvate kinase 0.0033 0.0181 0.067
Schistosoma mansoni glucose transporter 0.0015 0.0003 0.0005
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0181 0.0411
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0005
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.2747 0.3887
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0477 0.0671
Brugia malayi Muscleblind-like protein 0.0147 0.1289 0.1825
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.0052 0.0635
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.2747 0.3887
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0905 0.4186
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0206 0.0461
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0905 0.3664
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0206 0.0292
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0176 1
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0181 0.2324
Toxoplasma gondii exonuclease III APE 0.0019 0.0042 0.0505
Mycobacterium tuberculosis Probable reductase 0.0213 0.1927 0.893
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0046 0.0072
Schistosoma mansoni hypothetical protein 0.0066 0.0503 0.078
Loa Loa (eye worm) hypothetical protein 0.0437 0.4093 0.5796
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0046 0.0065
Echinococcus multilocularis pyruvate kinase 0.0017 0.0026 0.0026
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0744 0.7061 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1226 0.5675
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0084 0.012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0233 0.1064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0065
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0046 0.0046
Echinococcus granulosus dna polymerase kappa 0.0038 0.0233 0.0233
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0176 0.0176
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0003 0.0005
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0176 0.0393
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0063 0.0098
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0181 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0176 0.0245
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0046 0.0046
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0484 0.0484
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0046 0.0046
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0176 0.226
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0493 0.0694
Brugia malayi beta-lactamase 0.0036 0.0206 0.0292
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.1889 0.2675
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0213 0.1927 0.893
Schistosoma mansoni cpg binding protein 0.0065 0.0489 0.0757
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0046 0.0065
Leishmania major DNA polymerase eta, putative 0.0064 0.0477 0.0671
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.0052 0.0052
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0232 0.0328
Leishmania major trypanothione reductase 0.0094 0.0768 0.1083
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0206 0.0942
Brugia malayi jmjC domain containing protein 0.0112 0.0945 0.1338
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0493 0.0698
Echinococcus multilocularis dna polymerase eta 0.0064 0.0477 0.0477
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0093 0.0131
Loa Loa (eye worm) glutaminase 0.0271 0.2485 0.352
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.1216 0.1722
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0768 0.0768
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0206 0.0287
Loa Loa (eye worm) runx1 0.0055 0.0393 0.0556
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0181 0.0256
Schistosoma mansoni hypothetical protein 0.0143 0.1247 0.1933
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0206 0.0319
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2747 0.3887
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.1216 0.1722
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0222 0.2857
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0181 0.0256
Trichomonas vaginalis set domain proteins, putative 0.0469 0.4404 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0181 0.0181
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1226 0.5286
Brugia malayi MH2 domain containing protein 0.014 0.1216 0.1722
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0484 0.1937
Trypanosoma brucei unspecified product 0.0038 0.0233 0.0325
Schistosoma mansoni sugar transporter 0.0015 0.0003 0.0005
Brugia malayi 6-phosphofructokinase 0.0108 0.0905 0.1282
Brugia malayi hypothetical protein 0.0015 0.0003 0.0005
Giardia lamblia Pyruvate kinase 0.0017 0.0026 0.0085
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0206 0.0206
Plasmodium falciparum glutathione reductase 0.0094 0.0768 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0206 0.0287
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0674 0.8778
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0233 0.036
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0227 0.0227
Echinococcus granulosus cpg binding protein 0.0065 0.0489 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.044 0.0682
Onchocerca volvulus 0.0015 0.0003 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.044 0.0682
Loa Loa (eye worm) hypothetical protein 0.0036 0.0206 0.0292

Activities

Activity type Activity value Assay description Source Reference
ED20 (functional) ~ 1 mg kg-1 Dose required for hypotensive activity in anesthetized rat after intravenous administration ChEMBL. 6118439
ED20 (functional) = 18.2 mg kg-1 Dose required for antihypertensive activity in spontaneous hypertensive rats after oral administration ChEMBL. 6118439
ED50 (functional) = 0.0064 mg kg-1 Dose required for inhibition of isoproterenol-induced tachycardia in pithed rat after intravenous administration ChEMBL. 6118439
ED50 (functional) = 0.61 mg kg-1 Dose required for inhibition of L-phenylephrine-induced pressor response in pithed rats after intravenous administration ChEMBL. 6118439
Relative potency (functional) = 0.8 Relative potency required for inhibition of L-phenylephrine-induced pressor response in pithed rats ChEMBL. 6118439
Relative potency (functional) = 2.6 Relative potency required for antihypertensive activity in spontaneous hypertensive rats after oral administration ChEMBL. 6118439
Relative potency (functional) ~ 5.2 Relative potency required for hypotensive activity in anesthetized rat ChEMBL. 6118439
Relative potency (functional) = 21.9 Relative potency required for inhibition of isoproterenol-induced tachycardia in pithed rat after intravenous administration ChEMBL. 6118439

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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