Detailed information for compound 501373

Basic information

Technical information
  • TDR Targets ID: 501373
  • Name: 4-nitro-N-[(E)-pyridin-2-ylmethylideneamino]b enzamide
  • MW: 270.244 | Formula: C13H10N4O3
  • H donors: 1 H acceptors: 4 LogP: 1.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)[N+](=O)[O-])N/N=C/c1ccccn1
  • InChi: 1S/C13H10N4O3/c18-13(10-4-6-12(7-5-10)17(19)20)16-15-9-11-3-1-2-8-14-11/h1-9H,(H,16,18)/b15-9+
  • InChiKey: SSGCHTFAHFBUJG-OQLLNIDSSA-N  


Substructure search Similarity search

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Synonyms

  • 4-nitro-N-[(E)-2-pyridylmethyleneamino]benzamide
  • 4-nitro-N-(pyridin-2-ylmethylideneamino)benzamide
  • 4-nitro-N-(2-pyridylmethyleneamino)benzamide
  • 4-nitro-N'-[(1E)-pyridin-2-ylmethylene]benzohydrazide
  • MLS000660833
  • SMR000310471

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major phosphatidylinositol kinase, putative 0.0193 0.0119 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.5044 0.3488 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1005 0.0683 0.1874
Onchocerca volvulus 0.0193 0.0119 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Entamoeba histolytica protein kinase rad3, putative 0.0567 0.0379 0.5512
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0438 0.0289 0.0181
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0193 0.0119 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0193 0.0119 0.1687
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0567 0.0379 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0373 0.0244 0.2219
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1005 0.0683 0.1874
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.023 0.5
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1005 0.0683 0.1874
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1005 0.0683 1
Trichomonas vaginalis conserved hypothetical protein 0.0631 0.0424 0.5399
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0193 0.0119 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0379 0.4601
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0005 0.0479
Loa Loa (eye worm) phosphatidylinositol 3 0.1005 0.0683 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0193 0.0119 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0567 0.0379 0.4601
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1005 0.0683 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0193 0.0119 0.1748
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1005 0.0683 0.0579
Entamoeba histolytica hypothetical protein 0.0193 0.0119 0.1687
Toxoplasma gondii FATC domain-containing protein 0.0567 0.0379 0.4601
Loa Loa (eye worm) hypothetical protein 0.0567 0.0379 0.5545
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0193 0.0119 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0193 0.0119 0.0009
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0193 0.0119 1
Mycobacterium leprae conserved hypothetical protein 0.0193 0.0119 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0373 0.0244 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1005 0.0683 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0193 0.0119 0.1687
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1005 0.0683 0.0579
Leishmania major phosphatidylinositol 3-kinase, putative 0.0193 0.0119 0.0316
Loa Loa (eye worm) phosphatidylinositol 3 0.1005 0.0683 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0193 0.0119 0.1687
Leishmania major phosphatidylinositol 4-kinase, putative 0.0193 0.0119 0.0316
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.023 0.3323
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Leishmania major hypothetical protein, unknown function 0.0193 0.0119 0.0316
Loa Loa (eye worm) phosphatidylinositol 3 0.0193 0.0119 0.1748
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0005 0.0074
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0193 0.0119 0.0009
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0193 0.0119 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Brugia malayi FAT domain containing protein 0.0438 0.0289 0.4195
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0193 0.0119 0.1687
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0193 0.0119 0.0009
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0567 0.0379 0.077
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1005 0.0683 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.023 0.1968
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1005 0.0683 1
Plasmodium vivax hypothetical protein, conserved 0.0193 0.0119 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0005 0.0479
Echinococcus multilocularis 0.0193 0.0119 0.0009
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.023 0.1968
Loa Loa (eye worm) hypothetical protein 0.0373 0.0244 0.3579
Giardia lamblia GTOR 0.1005 0.0683 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.023 0.1968
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1005 0.0683 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0567 0.0379 0.077
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.023 0.3323
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1005 0.0683 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0193 0.0119 0.1748
Loa Loa (eye worm) hypothetical protein 0.018 0.011 0.1617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0379 0.4601
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0105 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1005 0.0683 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0105 0.8785
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0567 0.0379 0.5512
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0193 0.0119 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.023 0.1968
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0193 0.0119 0.1687
Brugia malayi Muscleblind-like protein 0.018 0.011 0.1555
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0193 0.0119 0.0316
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1005 0.0683 0.1673
Schistosoma mansoni hypothetical protein 0.0438 0.0289 0.3017
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0193 0.0119 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0379 0.4601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1005 0.0683 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.0564 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0379 0.4601
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0085 0.1249
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1005 0.0683 0.1673
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1005 0.0683 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1005 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1005 0.0683 0.1673
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0193 0.0119 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0193 0.0119 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0379 0.4601
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0193 0.0119 0.0009
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0193 0.0119 0.1687
Loa Loa (eye worm) hypothetical protein 0.0193 0.0119 0.1748
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0631 0.0424 0.5399
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.4421 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0631 0.0424 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0193 0.0119 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0438 0.0289 0.0181
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0005 0.0479
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.023 0.1968
Echinococcus multilocularis serine protein kinase ATM 0.0567 0.0379 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.023 0.1968
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0193 0.0119 0.0009
Echinococcus multilocularis Zinc finger, PHD finger 0.0193 0.0119 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0005 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0567 0.0379 0.4601
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0193 0.0119 0.1687
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0193 0.0119 0.1748
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0193 0.0119 0.1687
Loa Loa (eye worm) phosphatidylinositol 3 0.0193 0.0119 0.1748
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.1005 0.0683 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0193 0.0119 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0105 0.8732
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0005 0.0421
Echinococcus granulosus serine protein kinase ATM 0.0567 0.0379 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0567 0.0379 0.4601
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1005 0.0683 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0005 0.0479
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0193 0.0119 0.1687
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0193 0.0119 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0193 0.0119 0.1748
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0193 0.0119 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0005 0.0479
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0567 0.0379 0.0271
Loa Loa (eye worm) hypothetical protein 0.0631 0.0424 0.6203
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0379 0.4601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0193 0.0119 0.1687
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.023 0.1968
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0085 0.1249
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0193 0.0119 0.1687
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1005 0.0683 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.018 0.011 0.1617
Loa Loa (eye worm) hypothetical protein 0.0029 0.0005 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1005 0.0683 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0373 0.0244 0.2219
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0005 0.0479
Brugia malayi MH2 domain containing protein 0.0144 0.0085 0.1184
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0631 0.0424 0.5399
Entamoeba histolytica hypothetical protein 0.0567 0.0379 0.5512
Trypanosoma cruzi target of rapamycin kinase 3 0.1005 0.0683 0.1673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0379 0.4601
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0005 0.0479
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0005 0.0479
Toxoplasma gondii target of rapamycin (TOR), putative 0.1005 0.0683 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0567 0.0379 0.5512
Entamoeba histolytica hypothetical protein 0.0193 0.0119 0.1687
Loa Loa (eye worm) phosphatidylinositol 3 0.0193 0.0119 0.1748
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.023 0.1968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0567 0.0379 0.4601
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0193 0.0119 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0005 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.023 0.1968
Onchocerca volvulus 0.0193 0.0119 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0193 0.0119 0.1687
Trichomonas vaginalis conserved hypothetical protein 0.0438 0.0289 0.3017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0193 0.0119 0.1687
Loa Loa (eye worm) hypothetical protein 0.0193 0.0119 0.1748
Echinococcus granulosus microtubule associated protein 2 0.0833 0.0564 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.1005 0.0683 1
Entamoeba histolytica hypothetical protein 0.0193 0.0119 0.1687
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0193 0.0119 0.0316
Plasmodium vivax hypothetical protein 0.0193 0.0119 1
Leishmania major hypothetical protein, conserved 0.5237 0.3622 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0193 0.0119 0.0009
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1005 0.0683 0.1673
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0193 0.0119 0.1687
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.0564 0.7888
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0567 0.0379 0.5512
Entamoeba histolytica hypothetical protein 0.0193 0.0119 0.1687
Loa Loa (eye worm) hypothetical protein 0.0438 0.0289 0.4237

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 31.5 uM PUBCHEM_BIOASSAY: HTS Dose response counterscreen for assays utilizing the enzyme, b-galactosidase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1777, AID1778, AID1785, AID1786, AID2284, AID2285, AID2348, AID2352, AID2357, AID2359, AID2370, AID2420, AID2478, AID2491, AID2492, AID2493, AID2495, AID2497, AID2498, AID2500, AID434981, AID449737, AID463105, AID485352, AID488822, AID488842, AID488935] ChEMBL. No reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
IC50 (functional) = 14.7 uM PUBCHEM_BIOASSAY: uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1777, AID1785, AID1786, AID1966, AID2136, AID2285, AID2495, AID434981, AID463105, AID488826, AID488935] ChEMBL. No reference
IC50 (functional) > 32 uM PUBCHEM_BIOASSAY: HTS Image-Based Screen for Selective Antagonists of the KOR Receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1777, AID1778, AID1785, AID1786, AID2284, AID2285, AID2348, AID2352, AID2357, AID2359, AID2370, AID2420, AID2478, AID2491, AID2492, AID2493, AID2495, AID2497, AID2498, AID2500, AID434981, AID449737, AID463105, AID488822, AID488842, AID488935] ChEMBL. No reference
IC50 (ADMET) = 35.5 uM Antiproliferative activity against human SK-MN-C cells by MTT assay ChEMBL. 18159922
Potency (functional) = 3.1548 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.