Detailed information for compound 508475

Basic information

Technical information
  • TDR Targets ID: 508475
  • Name: 2-[6-cyano-3-[(2,2-difluoro-2-pyridin-2-yleth yl)amino]-2-fluorophenyl]-N-[2-(diaminomethyl ideneamino)oxyethyl]acetamide
  • MW: 435.403 | Formula: C19H20F3N7O2
  • H donors: 4 H acceptors: 3 LogP: 0.92 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(c(c1CC(=O)NCCONC(=N)N)F)NCC(c1ccccn1)(F)F
  • InChi: 1S/C19H20F3N7O2/c20-17-13(9-16(30)27-7-8-31-29-18(24)25)12(10-23)4-5-14(17)28-11-19(21,22)15-3-1-2-6-26-15/h1-6,28H,7-9,11H2,(H,27,30)(H4,24,25,29)
  • InChiKey: STHCHQXQLDMISY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[6-cyano-3-[[2,2-difluoro-2-(2-pyridyl)ethyl]amino]-2-fluoro-phenyl]-N-(2-guanidinooxyethyl)acetamide
  • 2-[6-cyano-3-[[2,2-difluoro-2-(2-pyridyl)ethyl]amino]-2-fluorophenyl]-N-(2-guanidinooxyethyl)acetamide
  • N-[2-[bis(azanyl)methylideneamino]oxyethyl]-2-[6-cyano-3-[(2,2-difluoro-2-pyridin-2-yl-ethyl)amino]-2-fluoro-phenyl]ethanamide
  • 2-[6-cyano-3-[(2,2-difluoro-2-pyridin-2-yl-ethyl)amino]-2-fluoro-phenyl]-N-[2-(diaminomethylideneamino)oxyethyl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0111 0.0184
Chlamydia trachomatis endonuclease IV 0.0075 0.1494 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0246 0.0246
Brugia malayi nuclear hormone receptor 0.0012 0.0079 0.0133
Mycobacterium ulcerans hypothetical protein 0.0035 0.0603 0.4038
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0376 0.0677
Onchocerca volvulus 0.0012 0.0072 0.0052
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0146 0.308 0.308
Onchocerca volvulus 0.0012 0.0072 0.0052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0376 0.0428
Onchocerca volvulus 0.0012 0.0072 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0452 0.0782
Loa Loa (eye worm) hypothetical protein 0.0035 0.0603 0.1048
Schistosoma mansoni cpg binding protein 0.003 0.0479 0.0546
Brugia malayi Uncoordinated protein 44 0.0029 0.0452 0.0817
Schistosoma mansoni hypothetical protein 0.0037 0.0641 0.073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0907 0.1651
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0226 0.3093
Toxoplasma gondii ABC1 family protein 0.0035 0.0603 0.4009
Brugia malayi ecdysone receptor 0.0012 0.0079 0.0133
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0603 0.0603
Echinococcus multilocularis geminin 0.0167 0.3528 0.3528
Entamoeba histolytica hypothetical protein 0.0019 0.0234 0.3028
Echinococcus multilocularis Ankyrin 0.0029 0.0457 0.0457
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0237 0.1587
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0111 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0237 0.3291
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0091 0.1513
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0091 0.1513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0376 0.0649
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0457 0.0521
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0603 0.1242
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0246 0.0246
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0282 0.4672
Brugia malayi Cytochrome P450 family protein 0.0016 0.0161 0.0284
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0234 0.0267
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0226 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.016 0.0183
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0376 0.0677
Schistosoma mansoni tyrosine kinase 0.0011 0.0058 0.0066
Brugia malayi hypothetical protein 0.0013 0.0111 0.0192
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0376 0.0376
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0079 0.0079
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.016 0.103
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.016 0.0271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0376 0.0376
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0091 0.0618
Entamoeba histolytica hypothetical protein 0.0019 0.0234 0.3028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0376 0.0677
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.009
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1202 0.137
Onchocerca volvulus 0.0049 0.0898 0.3054
Echinococcus granulosus C type lectin domian containing protein 0.0012 0.0072 0.0072
Brugia malayi hypothetical protein 0.0012 0.0079 0.0133
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0289 0.1892
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0289 0.0289
Loa Loa (eye worm) glutamate receptor 0.0019 0.0234 0.04
Schistosoma mansoni ap endonuclease 0.0018 0.0226 0.0258
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0079 0.0079
Onchocerca volvulus 0.0012 0.0079 0.0078
Brugia malayi bZIP transcription factor family protein 0.0171 0.3628 0.6642
Loa Loa (eye worm) hypothetical protein 0.0013 0.0111 0.0184
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0226 0.0466
Brugia malayi hypothetical protein 0.0019 0.0246 0.044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Leishmania major cytochrome p450-like protein 0.0016 0.0161 0.1901
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0012 0.0072 0.0115
Echinococcus multilocularis nmda type glutamate receptor 0.0011 0.0058 0.0058
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0091 0.0618
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0256 0.0527
Brugia malayi Doublecortin family protein 0.0019 0.0246 0.044
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0649
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.013 0.0411
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0058 0.009
Leishmania major DNA polymerase eta, putative 0.0019 0.0237 0.3291
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1149 0.1309
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Schistosoma mansoni hypothetical protein 0.0021 0.0289 0.0329
Brugia malayi hypoxia-induced factor 1 0.0148 0.3114 0.5698
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0058 0.0058
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1024 0.1024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0226 0.3093
Brugia malayi hypothetical protein 0.0012 0.0072 0.012
Brugia malayi Latrophilin receptor protein 2 0.0016 0.016 0.0281
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0234 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0289 0.4234
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0237 0.3077
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.016 0.0622
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0079 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0237 0.3291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Mycobacterium leprae Probable lipase LipE 0.0035 0.0603 0.4038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0091 0.0149
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0246 0.1226
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0649
Mycobacterium ulcerans lipase LipD 0.0035 0.0603 0.4038
Schistosoma mansoni protein kinase 0.0011 0.0058 0.0066
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0237 0.0423
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0161 0.1804
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0234 0.3884
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0603 0.1094
Toxoplasma gondii rhoptry neck protein RON9 0.0012 0.0072 0.0435
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0234 0.04
Echinococcus multilocularis cpg binding protein 0.003 0.0479 0.0479
Brugia malayi hypothetical protein 0.0134 0.2809 0.514
Loa Loa (eye worm) hypothetical protein 0.0035 0.0603 0.1048
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0234 0.0267
Loa Loa (eye worm) hypothetical protein 0.0019 0.0234 0.04
Loa Loa (eye worm) hypothetical protein 0.0019 0.0246 0.0421
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0237 0.3291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0237 0.0237
Brugia malayi ecdysteroid receptor 0.0025 0.0376 0.0677
Schistosoma mansoni hypothetical protein 0.0167 0.3528 0.4019
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0376 0.1157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0058 0.009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0237 0.0488
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Onchocerca volvulus Poor gastrulation protein homolog 0.0019 0.0234 0.0642
Schistosoma mansoni single-minded 0.0048 0.088 0.1003
Brugia malayi hypothetical protein 0.0012 0.0072 0.012
Echinococcus granulosus atrial natriuretic peptide receptor 0.0011 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0091 0.1513
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0603 0.4038
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.016 0.016
Loa Loa (eye worm) beta-lactamase 0.0035 0.0603 0.1048
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0226 0.0226
Onchocerca volvulus Netrin receptor homolog 0.0029 0.0452 0.1433
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0237 0.0423
Echinococcus granulosus RUN 0.0019 0.0246 0.0246
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0161 0.1901
Onchocerca volvulus 0.0012 0.0072 0.0052
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0234 0.0234
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0376 0.0376
Brugia malayi isocitrate dehydrogenase 0.0016 0.016 0.0282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Leishmania major DNA polymerase kappa, putative 0.0019 0.0237 0.3291
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0376 0.0376
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0058 0.0066
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0234 0.0267
Loa Loa (eye worm) hypothetical protein 0.0019 0.0234 0.04
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0013 0.0111 0.0184
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.016 0.016
Onchocerca volvulus 0.0019 0.0246 0.0686
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0234 0.0418
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0234 0.0418
Schistosoma mansoni coup transcription factor 0.0025 0.0376 0.0428
Entamoeba histolytica hypothetical protein 0.0037 0.0641 1
Brugia malayi TAR-binding protein 0.0062 0.1202 0.2193
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0079 0.0079
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0234 0.0234
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0561 0.1017
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0234 0.0234
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0237 0.027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0111 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0111 0.0184
Echinococcus multilocularis GPCR, family 3, C terminal 0.0019 0.0234 0.0234
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0079 0.0133
Echinococcus granulosus single minded 2 0.0035 0.0603 0.0603
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0376 0.0677
Brugia malayi hypothetical protein 0.0037 0.0641 0.1164
Mycobacterium tuberculosis Conserved protein 0.0035 0.0603 0.1242
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0603 0.3736
Brugia malayi PXA domain containing protein 0.0019 0.0234 0.0418
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1007 0.6722
Brugia malayi nuclear receptor NHR-88 0.0025 0.0376 0.0677
Schistosoma mansoni lipoxygenase 0.0019 0.0246 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0376 0.0677
Brugia malayi conserved hypotetical protein 0.0012 0.0079 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0091 0.1513
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0079 0.0079
Echinococcus granulosus nuclear factor of activated T cells 5 0.0146 0.308 0.308
Loa Loa (eye worm) hypothetical protein 0.0035 0.0603 0.1048
Brugia malayi Receptor family ligand binding region containing protein 0.0131 0.2736 0.5006
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.1494 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Onchocerca volvulus 0.0012 0.0079 0.0078
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.0452 0.0452
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.088 0.1003
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0161 0.108
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.016 0.0281
Schistosoma mansoni nuclear receptor 0.0012 0.0079 0.009
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0237 0.321
Echinococcus granulosus jun protein 0.0171 0.3628 0.3628
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0376 0.0677
Brugia malayi hypothetical protein 0.0012 0.0072 0.012
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0246 0.1608
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0079 0.0079
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.00000000059134
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0226 0.1474
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0091 0.1513
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.1494 0.2728
Onchocerca volvulus 0.0035 0.0603 0.1983
Echinococcus granulosus c4b binding protein beta chain 0.0012 0.0072 0.0072
Echinococcus multilocularis C type lectin domian containing protein 0.0012 0.0072 0.0072
Onchocerca volvulus 0.0035 0.0603 0.1983
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0603 0.4038
Brugia malayi nuclear hormone receptor 0.0025 0.0376 0.0677
Mycobacterium tuberculosis Conserved protein 0.0035 0.0603 0.1242
Echinococcus granulosus neuropeptide receptor A26 0.0457 1 1
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0282 0.0282
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0226 0.0386
Loa Loa (eye worm) hypothetical protein 0.0035 0.0603 0.1048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0603 0.1048
Onchocerca volvulus 0.0012 0.0072 0.0052
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0234 0.0234
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0603 0.1242
Schistosoma mansoni DNA polymerase eta 0.0019 0.0237 0.027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0376 0.0376
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0079 0.009
Brugia malayi hypothetical protein 0.0012 0.0072 0.012
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0079 0.009
Onchocerca volvulus 0.0019 0.0246 0.0686
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0058 0.0094
Trichomonas vaginalis esterase, putative 0.0035 0.0603 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0237 0.321
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0007 0.0007
Brugia malayi Guanylyl cyclase protein 23 0.0011 0.0058 0.0094
Echinococcus granulosus geminin 0.0167 0.3528 0.3528
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0091 0.0091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0603 0.1048
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0237 0.3291
Echinococcus granulosus dna polymerase kappa 0.0019 0.0237 0.0237
Entamoeba histolytica hypothetical protein 0.0037 0.0641 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0226 0.2892
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.016 0.103
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0111 0.0192
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.0001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0237 0.0237
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0161 0.1901
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0234 0.3884
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0603 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0011 0.0058 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1202 0.137
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0234 0.0418
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0376 0.0428
Loa Loa (eye worm) hypothetical protein 0.0019 0.0234 0.04
Schistosoma mansoni DNA helicase recq5 0.0009 0.0007 0.0008
Schistosoma mansoni lipoxygenase 0.0054 0.1024 0.1167
Echinococcus multilocularis neuropeptide receptor A26 0.0457 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.016 0.1788
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0603 1
Brugia malayi Sushi domain 0.0012 0.0072 0.012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.016 0.016
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0264 0.5703 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0376 0.0428
Schistosoma mansoni zinc finger protein 0.0012 0.0079 0.009
Onchocerca volvulus 0.0012 0.0072 0.0052
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0058 0.0058
Brugia malayi hypothetical protein 0.0012 0.0072 0.012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0376 0.0677
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0234 0.04
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0237 0.321
Brugia malayi beta-lactamase family protein 0.0035 0.0603 0.1094
Schistosoma mansoni jun-related protein 0.0139 0.2914 0.332
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0444 0.0768
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.016 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0649
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0603 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0226 0.3752
Schistosoma mansoni loxhd1 0.0019 0.0246 0.0281
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0376 0.0376
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0091 0.0618
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0376 0.0428
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0376 0.1157
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0226 0.301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0234 0.04
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.016 0.103
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0079 0.0078
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0007 0.0002
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0649
Echinococcus granulosus glutamate receptor 2 0.0011 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0016 0.016 0.0182
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0603 0.1242
Brugia malayi hypothetical protein 0.0012 0.0079 0.0133
Loa Loa (eye worm) hypothetical protein 0.0049 0.0907 0.1581
Echinococcus granulosus dna polymerase eta 0.0019 0.0237 0.0237
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0234 0.0418
Brugia malayi CXXC zinc finger family protein 0.0028 0.0444 0.0802
Loa Loa (eye worm) hypothetical protein 0.0021 0.0289 0.0496
Echinococcus granulosus bloom syndrome protein 0.0021 0.0282 0.0282
Loa Loa (eye worm) glutamate receptor 0.003 0.0478 0.0828
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0237 0.0488
Brugia malayi nuclear receptor NHR-67 0.0012 0.0079 0.0133
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.1494 1
Brugia malayi hypothetical protein 0.0019 0.0234 0.0418
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0019 0.0234 0.0267
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0091 0.0091
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0058 0.0058
Brugia malayi Cytochrome P450 family protein 0.0016 0.0161 0.0284
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0226 0.3093
Loa Loa (eye worm) hypothetical protein 0.003 0.0478 0.0828
Giardia lamblia DINP protein human, muc B family 0.0019 0.0237 1
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0376 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0649
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0376 0.0649
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0253 0.5459 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0091 0.0091
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0234 0.04
Brugia malayi hypothetical protein 0.016 0.3391 0.6206
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0091 0.1513
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0246 0.0246
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.1494 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.016 0.016
Echinococcus granulosus netrin receptor unc 5 0.0029 0.0452 0.0452
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0603 0.1242
Echinococcus granulosus Ankyrin 0.0029 0.0457 0.0457
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0019 0.0234 0.0418
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0234 0.0267
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0282 0.0505
Brugia malayi beta-lactamase 0.0035 0.0603 0.1094
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0079 0.0079
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0246 0.0246
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0452 0.0817
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0167 0.3528 0.4019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0171 0.3628 0.3628
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0376 0.1157
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.0452 0.0452
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0641 0.0641
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1202 0.137
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0091 0.0618
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0091 0.1513
Brugia malayi nuclear receptor RXR 0.0013 0.0111 0.0192
Brugia malayi hypothetical protein 0.0012 0.0072 0.012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.4855 1
Schistosoma mansoni rab6-interacting 0.0019 0.0246 0.0281
Loa Loa (eye worm) hypothetical protein 0.0019 0.0234 0.04
Echinococcus granulosus GPCR family 2 0.0016 0.016 0.016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0111 0.0111
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.016 0.1885
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0234 0.0234
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.009
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0161 0.0272
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0376 0.0376
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.016 0.033
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0079 0.0128
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.0058 0.0058
Brugia malayi steroid hormone receptor 0.0025 0.0376 0.0677
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0376 0.0428
Schistosoma mansoni hypothetical protein 0.0016 0.016 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0376 0.0677
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0237 0.321
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0603 1
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0079 0.0079
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0079 0.0078
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0064 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0376 0.0677
Mycobacterium ulcerans epimerase 0.002 0.0256 0.1713
Onchocerca volvulus 0.0134 0.2809 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0376 0.0376
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0237 0.3931
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.8778 0.8778
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0246 0.0421
Echinococcus multilocularis RUN 0.0019 0.0246 0.0246
Leishmania major hypothetical protein, conserved 0.0021 0.0289 0.4234
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0376 0.0428
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.016 0.1788
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0603 0.0603
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0603 0.0687
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0376 0.0649
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0478 0.0864
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.009
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0376 0.0649
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1024 0.1024
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0234 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0376 0.0677
Schistosoma mansoni hypothetical protein 0.0016 0.016 0.0182
Loa Loa (eye worm) RNA binding protein 0.0062 0.1202 0.21
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0171 0.3628 0.3628
Schistosoma mansoni hypothetical protein 0.0402 0.8778 1
Onchocerca volvulus 0.0025 0.0376 0.1157
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0234 0.0234
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.016 0.1885
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0058 0.0058
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0019 0.0234 0.0642
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0907 0.1651
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0376 0.0677
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0079 0.0133
Echinococcus multilocularis c4b binding protein beta chain 0.0012 0.0072 0.0072
Onchocerca volvulus 0.0035 0.0603 0.1983
Schistosoma mansoni hypothetical protein 0.0139 0.2914 0.332
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0234 0.0234
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.016 0.016
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0256 0.0458
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0603 1
Echinococcus granulosus dnaJ subfamily B 0.0402 0.8778 0.8778
Loa Loa (eye worm) DR-78 0.0012 0.0079 0.0128
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0064 0.0118
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0234 0.0267
Brugia malayi nuclear receptor NHR-88 0.0012 0.0079 0.0133
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0183 0.0209
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0234 0.0418
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0234 0.0234
Onchocerca volvulus 0.0012 0.0072 0.0052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.0001
Echinococcus granulosus nmda type glutamate receptor 0.0011 0.0058 0.0058
Trypanosoma brucei unspecified product 0.0013 0.0106 0.0776
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0376 0.0376
Brugia malayi hypothetical protein 0.0019 0.0234 0.0418
Loa Loa (eye worm) hypothetical protein 0.0013 0.0111 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1202 0.137
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0234 0.3884
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0376 0.0376
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0376 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0106 0.0776
Onchocerca volvulus 0.0035 0.0603 0.1983
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0907 0.1581
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0603 0.0687
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1202 0.21
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0091 0.1513
Loa Loa (eye worm) hypothetical protein 0.0013 0.0111 0.0184
Echinococcus multilocularis dna polymerase eta 0.0019 0.0237 0.0237
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0091 0.0618
Echinococcus granulosus metabotropic glutamate receptor 2 0.0011 0.0058 0.0058
Schistosoma mansoni polycystin 1-related 0.0019 0.0246 0.0281
Brugia malayi pregnancy-associated plasma protein-A 0.0012 0.0072 0.012
Schistosoma mansoni nuclear receptor 0.0012 0.0079 0.009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0649
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0058 0.009
Echinococcus granulosus glutamate receptor 2 0.0011 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0033 0.0561 0.0974
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0226 0.1515
Loa Loa (eye worm) hypothetical protein 0.0049 0.0898 0.1566
Onchocerca volvulus 0.0021 0.0289 0.084
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0111 0.0126
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0603 0.1094
Brugia malayi RNA binding protein 0.0062 0.1202 0.2193
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1202 0.21
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0234 0.3884
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0161 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0376 0.0649
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Mycobacterium leprae Possible regulatory protein 0.0012 0.0091 0.0611
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0603 1
Brugia malayi GCC2 and GCC3 family protein 0.0012 0.0072 0.012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0603 0.1048
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.016 0.3391 0.5941
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0237 0.1587
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0011 0.0058 0.0058
Schistosoma mansoni metabotropic glutamate receptor 0.0011 0.0058 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.009
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0234 0.0267
Loa Loa (eye worm) hypothetical protein 0.0166 0.3524 0.6175
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0234 0.0267
Entamoeba histolytica hypothetical protein 0.0019 0.0234 0.3028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0234 0.04
Schistosoma mansoni hypothetical protein 0.0033 0.0561 0.0639
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0376 0.0677
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.0452 0.0515
Brugia malayi PXA domain containing protein 0.0019 0.0234 0.0418
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0111 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0106 0.0776
Echinococcus multilocularis tyrosine kinase 0.0011 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0478 0.0828
Trypanosoma brucei unspecified product 0.0019 0.0237 0.321
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0282 0.4672
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Brugia malayi tailless protein 0.0012 0.0079 0.0133
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0091 0.1513
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Echinococcus granulosus death domain containing protein 0.0029 0.0452 0.0452
Echinococcus granulosus tumor protein p63 0.0332 0.7219 0.7219
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0064 0.1061
Brugia malayi PAS domain containing protein 0.0048 0.088 0.1602
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0289 0.1523
Brugia malayi Metabotropic glutamate receptor precursor. 0.003 0.0478 0.0864
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0079 0.009
Echinococcus granulosus expressed protein 0.0367 0.7994 0.7994
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0079 0.0133
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0091 0.0618
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0079 0.0133
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0058 0.0058
Brugia malayi hypothetical protein 0.0019 0.0246 0.044
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0603 0.1242
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0226 0.1086
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0237 0.3291
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0234 0.0234
Mycobacterium ulcerans hypothetical protein 0.002 0.0256 0.1713
Brugia malayi beta-lactamase family protein 0.0035 0.0603 0.1094
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.1494 0.3077
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0234 0.0267
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0079 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0376 0.0677
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0603 0.1242
Brugia malayi hypothetical protein 0.0013 0.0111 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0603 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0002
Echinococcus granulosus metabotropic glutamate receptor 5 0.003 0.0478 0.0478
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0256 0.1713
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.016 0.1885
Schistosoma mansoni c4b-binding protein beta chain 0.0012 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0234 0.04
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0234 0.0418
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0376 0.0376
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0079 0.0133
Toxoplasma gondii exonuclease III APE 0.0018 0.0226 0.1474
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0641 0.073
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0237 0.027
Plasmodium falciparum apical sushi protein 0.0012 0.0072 0.0435
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0058 0.0058
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0234 0.0267
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0376 0.0376
Toxoplasma gondii rhoptry neck protein RON1 0.0012 0.0072 0.0435
Echinococcus multilocularis netrin receptor unc 5 0.0029 0.0452 0.0452
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0289 0.0496
Echinococcus granulosus cpg binding protein 0.003 0.0479 0.0479
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0649
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.0478 0.0544
Echinococcus multilocularis metabotropic glutamate receptor 5 0.003 0.0478 0.0478
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0091 0.0149
Entamoeba histolytica hypothetical protein 0.0037 0.0641 1
Brugia malayi Protein kinase domain containing protein 0.0021 0.0289 0.0517
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0603 0.4038
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1202 0.1202
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0234 0.0267
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0387 0.0669
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0127 0.0803
Loa Loa (eye worm) hypothetical protein 0.002 0.0256 0.0438
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0058 0.0058
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0256 0.0721
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0115
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0452 0.0782
Brugia malayi Isocitrate dehydrogenase 0.0016 0.016 0.0282
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0246 0.0246
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0234 0.04
Loa Loa (eye worm) hypothetical protein 0.0019 0.0237 0.0405
Loa Loa (eye worm) RecQ helicase 0.0021 0.0282 0.0484
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0226 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0234 0.0267
Schistosoma mansoni hypothetical protein 0.0016 0.016 0.0182
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0237 0.3931
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0091 0.1513
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0376 0.0649
Mycobacterium leprae conserved hypothetical protein 0.002 0.0256 0.1713
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.3114 0.5455
Schistosoma mansoni tyrosine kinase 0.0011 0.0058 0.0066
Echinococcus granulosus tyrosine kinase 0.0011 0.0058 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.016 0.016
Schistosoma mansoni rab6-interacting 0.0019 0.0246 0.0281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0079 0.0079
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0898 0.1023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.016 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0106 0.0776
Schistosoma mansoni hypothetical protein 0.0019 0.0246 0.0281
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0376 0.0428
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.009
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0079 0.0133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.009
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0376 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0234 0.3884
Echinococcus multilocularis tumor protein p63 0.0332 0.7219 0.7219
Onchocerca volvulus 0.0012 0.0072 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0603 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0011 0.0058 0.0058
Leishmania major protein kinase, putative 0.0012 0.0091 0.0618
Brugia malayi Kringle domain containing protein 0.0021 0.0289 0.0517
Schistosoma mansoni ap endonuclease 0.0018 0.0226 0.0258
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0376 0.0649
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0226 1
Toxoplasma gondii endonuclease IV APN 0.0075 0.1494 1
Brugia malayi Protein kinase domain containing protein 0.0029 0.0452 0.0817
Brugia malayi Death domain containing protein 0.0029 0.0452 0.0817
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0603 0.1242
Mycobacterium ulcerans endonuclease IV 0.0075 0.1494 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0091 0.0091
Onchocerca volvulus 0.0012 0.0072 0.0052
Brugia malayi Cytochrome P450 family protein 0.0026 0.0387 0.0699
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0376 0.0428
Echinococcus granulosus tar DNA binding protein 0.0062 0.1202 0.1202
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0226 0.0403
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0234 0.3884
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0131 0.2736 0.4792
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0234 0.04
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0376 0.0649
Mycobacterium tuberculosis Conserved protein 0.0035 0.0603 0.1242
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0079 0.009
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0161 0.0272
Brugia malayi hypothetical protein 0.0012 0.0072 0.012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1202 0.2193
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0091 0.1513
Leishmania major protein kinase, putative 0.0012 0.0091 0.0618
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0234 0.0267
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0246 0.0421
Schistosoma mansoni cpg binding protein 0.003 0.0479 0.0546
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0226 0.9531
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0376 0.0376
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0289 0.1892
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.0058 0.0058
Onchocerca volvulus 0.0012 0.0072 0.0052
Leishmania major hypothetical protein, conserved 0.0035 0.0603 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0225 0.1465
Mycobacterium ulcerans beta-lactamase 0.0035 0.0603 0.4038
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0075 0.1494 0.2612
Brugia malayi nuclear receptor RXR 0.0012 0.0079 0.0133
Echinococcus multilocularis jun protein 0.0171 0.3628 0.3628
Schistosoma mansoni cpg binding protein 0.0028 0.0444 0.0505
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0079 0.009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1202 0.137
Onchocerca volvulus 0.0028 0.0444 0.1403
Schistosoma mansoni netrin receptor unc5 0.0029 0.0452 0.0515
Echinococcus multilocularis GPCR, family 2 0.0016 0.016 0.016
Echinococcus multilocularis expressed protein 0.0367 0.7994 0.7994
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0234 0.0234
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0376 0.0376
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0016 0.016 0.027
Trypanosoma brucei unspecified product 0.0013 0.0106 0.0776
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0237 0.0405
Schistosoma mansoni hypothetical protein 0.0019 0.0234 0.0267
Schistosoma mansoni hypothetical protein 0.0029 0.0452 0.0515
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0011 0.0058 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0237 0.321
Onchocerca volvulus 0.0012 0.0091 0.0122
Entamoeba histolytica hypothetical protein 0.0037 0.0641 1
Brugia malayi hypothetical protein 0.0011 0.0058 0.0094
Loa Loa (eye worm) hypothetical protein 0.0017 0.0187 0.0318
Loa Loa (eye worm) hypothetical protein 0.0029 0.0457 0.0792
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0376 0.0428
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0237 0.0237
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0246 0.0246
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0376 0.0677
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.016 0.016
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0091 0.0618
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0237 0.3291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0128
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0226 0.3752
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0376 0.0428
Schistosoma mansoni DNA helicase recq1 0.0009 0.0007 0.0008
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0376 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0376 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0234 0.3884
Echinococcus multilocularis neuropeptide s receptor 0.0457 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0649
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0234 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0376 0.0677
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0234 0.0234
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0376 0.0428
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0064 0.0118
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0603 0.4038
Echinococcus granulosus GPCR family 3 C terminal 0.0019 0.0234 0.0234

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) >= 2.5 Anticoagulant activity in conscious dog plasma assessed as increase in activated partial thromboplastin time at 10 mg/kg, po after 3 hrs relative to baseline ChEMBL. 18420408
Activity (functional) = 5 hr Anticoagulant activity in dog plasma assessed as time required to double activated partial thromboplastin time at 10 mg/kg, po after 8 hrs ChEMBL. 18420408
Activity (functional) = 0.36 uM Anticoagulant activity in human plasma assessed as concentration required to double activated partial thromboplastin time ChEMBL. 18420408
CL (ADMET) = 13 ml/min.kg Clearance in dog at 1 mg/kg, iv ChEMBL. 18420408
CL (ADMET) = 30 ml/min.kg Clearance in rat at 2 mg/kg, iv ChEMBL. 18420408
Cmax (ADMET) = 0.03 uM Cmax in rat at 10 mg/kg, po ChEMBL. 18420408
Cmax (ADMET) = 3.5 uM Cmax in dog at 10 mg/kg, po ChEMBL. 18420408
ED50 (functional) = 40 ug/kg Antithrombotic activity in iv dosed rat electrically stimulated carotid artery model ChEMBL. 18420408
F (ADMET) = 2 % Bioavailability in rat at 10 mg/kg, po ChEMBL. 18420408
F (ADMET) = 49 % Bioavailability in dog at 10 mg/kg, po ChEMBL. 18420408
Fold change (functional) = 2.83 Anticoagulant activity in dog plasma assessed as time required to maximise activated partial thromboplastin time at 10 mg/kg, po after 8 hrs relative to baseline ChEMBL. 18420408
Inhibition (functional) = 51 % Inhibition of thrombus formation in dog arteriovenous-shunt model at 3 mg/kg, po after 5 hrs ChEMBL. 18420408
Inhibition (binding) = 85 % Inhibition of human ERG ion channel at 10 uM by patch clamp assay ChEMBL. 18420408
Inhibition (binding) = 85 % Inhibition of human ERG ion channel at 10 uM by patch clamp assay ChEMBL. 18420408
Ki (binding) = 1.2 nM Binding affinity to human thrombin ChEMBL. 18420408
Ki (binding) = 1.2 nM Binding affinity to human thrombin ChEMBL. 18420408
Papp (ADMET) = 0.9 10^-6 cm/s Apparent permeability from apical to basolateral side of the human CaCO2 membrane ChEMBL. 18420408
Papp (ADMET) = 8.5 10^-6 cm/s Apparent permeability from basolateral to apical side of the human CaCO2 membrane ChEMBL. 18420408
PPB (ADMET) = 56 % Protein binding in human plasma ChEMBL. 18420408
PPB (ADMET) <= 69 % Protein binding in dog plasma ChEMBL. 18420408
PPB (ADMET) <= 69 % Protein binding in rat plasma ChEMBL. 18420408
Ratio (ADMET) = 9.7 Ratio of apparent permeability from apical to basolateral over basolateral to apical side of human CaCO2 cells membrane ChEMBL. 18420408
Ratio Ki (binding) = 1170 Ratio of Ki for human thrombin to Ki for trypsin (unknown origin) ChEMBL. 18420408
Stabilty (ADMET) >= 86 % Metabolic stability in human liver microsomes after 10 mins ChEMBL. 18420408
Stabilty (ADMET) >= 86 % Metabolic stability in dog liver microsomes after 10 mins ChEMBL. 18420408
Stabilty (ADMET) > 95 % Metabolic stability in rat liver microsomes after 10 mins ChEMBL. 18420408
t1/2 (ADMET) = 1 hr Half life in rat at 2 mg/kg, iv ChEMBL. 18420408
t1/2 (ADMET) = 2.5 hr Half life in dog at 10 mg/kg, po ChEMBL. 18420408
t1/2 (ADMET) = 2.9 hr Half life in dog at 1 mg/kg, iv ChEMBL. 18420408
Vdss (ADMET) = 2.9 L/Kg Volume of distribution at steady state in dog at 1 mg/kg, iv ChEMBL. 18420408
Vdss (ADMET) = 6 L/Kg Volume of distribution at steady state in rat at 2 mg/kg, iv ChEMBL. 18420408

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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