Detailed information for compound 511022

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 317.836 | Formula: C16H16ClN3S
  • H donors: 2 H acceptors: 0 LogP: 3.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C(\c1cccc(c1)Cl)/CCc1ccccc1
  • InChi: 1S/C16H16ClN3S/c17-14-8-4-7-13(11-14)15(19-20-16(18)21)10-9-12-5-2-1-3-6-12/h1-8,11H,9-10H2,(H3,18,20,21)/b19-15-
  • InChiKey: ZPJOOIQETRZYQI-CYVLTUHYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.00319348 0.0461868 0.0708717
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Schistosoma mansoni sodium/chloride dependent transporter 0.00968628 0.182592 0.412678
Loa Loa (eye worm) carboxylesterase 0.00127248 0.0058289 0.0058289
Schistosoma mansoni nAChR subunit 0.00183333 0.0176118 0.0398045
Brugia malayi putative neuropeptide receptor NPR1 0.00436326 0.0707623 0.108582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Schistosoma mansoni voltage-gated potassium channel 0.00359661 0.0546561 0.123529
Loa Loa (eye worm) hypothetical protein 0.00127248 0.0058289 0.0058289
Loa Loa (eye worm) hypothetical protein 0.00214112 0.024078 0.024078
Echinococcus granulosus sodium and chloride dependent glycine 0.00164428 0.0136399 0.0536549
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.00127248 0.0058289 0.0557676
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00436326 0.0707623 0.0707623
Brugia malayi hypothetical protein 0.00183333 0.0176118 0.0270246
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00164428 0.0136399 0.0308277
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.0461868 0.181683
Schistosoma mansoni nAChR subunit 0.00397445 0.062594 0.141469
Brugia malayi G-protein coupled receptor 0.00436326 0.0707623 0.108582
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00339301 0.0503787 0.198173
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00436326 0.0707623 0.108582
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.00127248 0.0058289 0.5
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.00164428 0.0136399 0.5
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Loa Loa (eye worm) G-protein coupled receptor 0.00436326 0.0707623 0.0707623
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.00183333 0.0176118 0.0692789
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Trichomonas vaginalis dynamin, putative 0.001373 0.00794076 0.0759728
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00164428 0.0136399 0.0209299
Loa Loa (eye worm) hypothetical protein 0.00164428 0.0136399 0.0136399
Echinococcus granulosus cysteine protease 0.00188629 0.0187244 0.0736553
Loa Loa (eye worm) hypothetical protein 0.0114958 0.220609 0.220609
Plasmodium falciparum cysteine proteinase falcipain 2a 0.00319348 0.0461868 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.00127248 0.0058289 0.0229289
Plasmodium vivax vivapain-2 0.00319348 0.0461868 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Loa Loa (eye worm) hypothetical protein 0.00214112 0.024078 0.024078
Schistosoma mansoni glutamate receptor kainate 0.00339301 0.0503787 0.113861
Echinococcus granulosus g-protein coupled receptor 0.00436326 0.0707623 0.278355
Echinococcus granulosus cathepsin L 0.00188629 0.0187244 0.0736553
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00127248 0.0058289 0.0131739
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Echinococcus granulosus glutamate receptor 2 0.00339301 0.0503787 0.198173
Echinococcus multilocularis glycine receptor subunit alpha 1 0.00397445 0.062594 0.246224
Onchocerca volvulus 0.00230221 0.0274624 0.124485
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.00125561 0.00547447 0.0215347
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Echinococcus granulosus neuroligin 0.00127248 0.0058289 0.0229289
Loa Loa (eye worm) hypothetical protein 0.0114958 0.220609 0.220609
Echinococcus multilocularis neuropeptide receptor 0.00436326 0.0707623 0.278355
Brugia malayi Papain family cysteine protease containing protein 0.00188629 0.0187244 0.0287318
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00968628 0.182592 0.412678
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018915 0.0188339 0.180192
Brugia malayi Dynamin 0.00147805 0.0101478 0.0155714
Schistosoma mansoni biogenic amine (5HT) receptor 0.00436326 0.0707623 0.15993
Onchocerca volvulus 0.00319348 0.0461868 0.209361
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 0.254216 0.574555
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus neuropeptide receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Schistosoma mansoni sodium/chloride dependent transporter 0.00164428 0.0136399 0.0308277
Echinococcus granulosus glutamate receptor subunit protein glur 0.00125561 0.00547447 0.0215347
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0018915 0.0188339 0.0740862
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.00597015 0.104521 1
Loa Loa (eye worm) glutamate receptor 2 0.00339301 0.0503787 0.0503787
Schistosoma mansoni nAChR subunit 0.00397445 0.062594 0.141469
Schistosoma mansoni neurotransmitter gated ion channel 0.00214112 0.024078 0.0544188
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0018915 0.0188339 0.0425666
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.00397445 0.062594 0.246224
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00397445 0.062594 0.096048
Echinococcus granulosus orexin receptor type 2 0.00436326 0.0707623 0.278355
Schistosoma mansoni cathepsin F (C01 family) 0.00230221 0.0274624 0.0620679
Brugia malayi excitatory GABA receptor EXP-1A 0.00397445 0.062594 0.096048
Onchocerca volvulus 0.00397445 0.062594 0.283733
Loa Loa (eye worm) hypothetical protein 0.00164428 0.0136399 0.0136399
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00326218 0.0476301 0.187361
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus multilocularis orexin receptor type 2 0.00436326 0.0707623 0.278355
Toxoplasma gondii dynamin-related protein DRPB 0.001373 0.00794076 0.0759728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Schistosoma mansoni glutamate receptor kainate 0.00339301 0.0503787 0.113861
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.00397445 0.062594 0.141469
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00299254 0.0419654 0.401501
Echinococcus multilocularis g protein coupled receptor 0.00436326 0.0707623 0.278355
Echinococcus multilocularis g protein coupled receptor 0.00436326 0.0707623 0.278355
Brugia malayi cathepsin L-like precursor 0.00230221 0.0274624 0.04214
Schistosoma mansoni opsin-like receptor 0.00436326 0.0707623 0.15993
Echinococcus granulosus somatostatin receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00436326 0.0707623 0.278355
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Leishmania major cathepsin L-like protease 0.00319348 0.0461868 0.396002
Schistosoma mansoni dynamin 0.00147805 0.0101478 0.0229351
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00164428 0.0136399 0.0209299
Echinococcus multilocularis neuropeptide Y receptor 0.00436326 0.0707623 0.278355
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.0461868 0.181683
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.00164428 0.0136399 0.0536549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00436326 0.0707623 0.278355
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.00183333 0.0176118 0.0270246
Echinococcus granulosus neuropeptide FF receptor 2 0.00436326 0.0707623 0.278355
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00127248 0.0058289 0.0058289
Onchocerca volvulus 0.00319348 0.0461868 0.209361
Echinococcus multilocularis neuroligin 0.00127248 0.0058289 0.0229289
Schistosoma mansoni myosin xvIII 0.00436326 0.0707623 0.15993
Echinococcus multilocularis neuropeptide receptor A26 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Entamoeba histolytica cysteine proteinase, putative 0.00230221 0.0274624 0.594595
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Echinococcus multilocularis cysteine protease 0.00319348 0.0461868 0.181683
Loa Loa (eye worm) hypothetical protein 0.00968628 0.182592 0.182592
Loa Loa (eye worm) DRP-1 protein 0.001373 0.00794076 0.00794076
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.00397445 0.062594 0.141469
Echinococcus granulosus neuropeptide receptor A26 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00164428 0.0136399 0.0136399
Echinococcus granulosus cathepsin L cysteine protease 0.00188629 0.0187244 0.0736553
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0018915 0.0188339 0.180192
Echinococcus multilocularis sex peptide receptor 0.00436326 0.0707623 0.278355
Brugia malayi Cathepsin L-like precursor 0.00319348 0.0461868 0.0708717
Schistosoma mansoni cathepsin F (C01 family) 0.00319348 0.0461868 0.104387
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00164428 0.0136399 0.0209299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.0187244 0.042319
Loa Loa (eye worm) hypothetical protein 0.00230221 0.0274624 0.0274624
Brugia malayi G-protein coupled receptor 0.00436326 0.0707623 0.108582
Trypanosoma cruzi cysteine peptidase, putative 0.00188629 0.0187244 0.0736553
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) ACC-1 protein 0.00397445 0.062594 0.062594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00188629 0.0187244 0.111654
Onchocerca volvulus 0.00319348 0.0461868 0.209361
Brugia malayi Carboxylesterase family protein 0.00127248 0.0058289 0.0089442
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Echinococcus multilocularis glutamate receptor subunit protein glur 0.00125561 0.00547447 0.0215347
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00436326 0.0707623 0.278355
Echinococcus granulosus glycine receptor subunit beta 0.00397445 0.062594 0.246224
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.00125561 0.00547447 0.0215347
Schistosoma mansoni hypothetical protein 0.00125561 0.00547447 0.0123729
Onchocerca volvulus 0.00183333 0.0176118 0.0798329
Echinococcus granulosus serotonin transporter 0.00968628 0.182592 0.718256
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00436326 0.0707623 0.278355
Onchocerca volvulus Putative nachr subunit 0.0114958 0.220609 1
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0018915 0.0188339 0.0188339
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00339301 0.0503787 0.198173
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.00164428 0.0136399 0.0536549
Echinococcus multilocularis para nitrobenzyl esterase 0.00127248 0.0058289 0.0229289
Schistosoma mansoni BC026374 protein (S09 family) 0.00127248 0.0058289 0.0131739
Onchocerca volvulus 0.00319348 0.0461868 0.209361
Schistosoma mansoni voltage-gated potassium channel 0.00106648 0.00150124 0.00339296
Loa Loa (eye worm) hypothetical protein 0.0320152 0.651695 0.651695
Schistosoma mansoni opsin-like receptor 0.00436326 0.0707623 0.15993
Schistosoma mansoni neuroligin 3 (S09 family) 0.00127248 0.0058289 0.0131739
Entamoeba histolytica G protein alpha subunit, putative 0.0018915 0.0188339 0.407777
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.00183333 0.0176118 0.0692789
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Loa Loa (eye worm) hypothetical protein 0.00214112 0.024078 0.024078
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Schistosoma mansoni amine GPCR 0.00436326 0.0707623 0.15993
Brugia malayi Tachykinin-like peptides receptor 99D 0.00436326 0.0707623 0.108582
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0114958 0.220609 0.867799
Echinococcus granulosus nAChR subunit 0.00214112 0.024078 0.0947147
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.00183333 0.0176118 0.0270246
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.0187244 0.405405
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.00214112 0.024078 0.0544188
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00183333 0.0176118 0.0270246
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.00164428 0.0136399 0.0209299
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.00164428 0.0136399 0.0536549
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00436326 0.0707623 0.278355
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Plasmodium vivax hypothetical protein, conserved 0.00164428 0.0136399 0.295321
Trichomonas vaginalis dynamin, putative 0.001373 0.00794076 0.0759728
Brugia malayi Cathepsin L-like precursor 0.00230221 0.0274624 0.04214
Brugia malayi Cathepsin L-like precursor 0.00319348 0.0461868 0.0708717
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Onchocerca volvulus 0.00127248 0.0058289 0.0264219
Loa Loa (eye worm) G-protein coupled receptor 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.0018915 0.0188339 0.0188339
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018915 0.0188339 0.0425666
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.00397445 0.062594 0.246224
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00436326 0.0707623 0.15993
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.00397445 0.062594 0.096048
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0018915 0.0188339 0.0288998
Echinococcus granulosus glycine receptor subunit alpha 1 0.00397445 0.062594 0.246224
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00127248 0.0058289 0.0131739
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018915 0.0188339 0.0425666
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Plasmodium falciparum amino acid transporter, putative 0.00164428 0.0136399 0.295321
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.00397445 0.062594 0.096048
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018915 0.0188339 0.0425666
Brugia malayi neuropeptide F receptor 0.00436326 0.0707623 0.108582
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Brugia malayi Carboxylesterase family protein 0.00127248 0.0058289 0.0089442
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00339301 0.0503787 0.198173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Loa Loa (eye worm) GABA receptor subunit 0.00214112 0.024078 0.024078
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00397445 0.062594 0.096048
Schistosoma mansoni biogenic amine receptor 0.00436326 0.0707623 0.15993
Schistosoma mansoni neurotransmitter gated ion channel 0.00183333 0.0176118 0.0398045
Plasmodium falciparum dynamin-like protein 0.001373 0.00794076 0.171927
Leishmania major cathepsin L-like protease 0.00319348 0.0461868 0.396002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00164428 0.0136399 0.0308277
Loa Loa (eye worm) hypothetical protein 0.00164428 0.0136399 0.0136399
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Schistosoma mansoni nAChR subunit 0.00397445 0.062594 0.141469
Echinococcus multilocularis acetylcholinesterase 0.00753098 0.137312 0.54014
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.00397445 0.062594 0.096048
Onchocerca volvulus Neuropeptide F receptor homolog 0.00436326 0.0707623 0.32076
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00164428 0.0136399 0.0308277
Trichomonas vaginalis spcc417.12 protein, putative 0.00127248 0.0058289 0.0557676
Plasmodium vivax vivapain-1 0.00188629 0.0187244 0.405405
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Schistosoma mansoni nAChR subunit 0.00397445 0.062594 0.141469
Entamoeba histolytica cysteine protease, putative 0.00319348 0.0461868 1
Giardia lamblia Cathepsin B precursor 0.00597015 0.104521 1
Schistosoma mansoni neuropeptide F-like receptor 0.00436326 0.0707623 0.15993
Echinococcus granulosus cathepsin b 0.0130955 0.254216 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.00397445 0.062594 0.246224
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.00397445 0.062594 0.246224
Echinococcus multilocularis G-protein coupled receptor, putative 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Brugia malayi Papain family cysteine protease containing protein 0.00188629 0.0187244 0.0287318
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Trypanosoma cruzi cysteine proteinase, putative 0.00188629 0.0187244 0.0736553
Loa Loa (eye worm) hypothetical protein 0.00214112 0.024078 0.024078
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.00397445 0.062594 0.062594
Onchocerca volvulus 0.00319348 0.0461868 0.209361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00188629 0.0187244 0.111654
Echinococcus granulosus tm gpcr rhodopsin 0.00436326 0.0707623 0.278355
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0114958 0.220609 0.498598
Entamoeba histolytica dynamin-1-like protein, putative 0.001373 0.00794076 0.171927
Onchocerca volvulus 0.00214112 0.024078 0.109144
Loa Loa (eye worm) glutamate receptor 1 0.00339301 0.0503787 0.0503787
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.0130955 0.254216 0.254216
Echinococcus granulosus 7tm_1 domain containing protein 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00127248 0.0058289 0.0058289
Echinococcus granulosus peptide allatostatin:somatostatin 0.00436326 0.0707623 0.278355
Schistosoma mansoni nAChR subunit 0.00397445 0.062594 0.141469
Loa Loa (eye worm) cathepsin B 0.00597015 0.104521 0.104521
Echinococcus granulosus nmda type glutamate receptor 0.00125561 0.00547447 0.0215347
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.00183333 0.0176118 0.0176118
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Echinococcus multilocularis voltage gated potassium channel 0.00106648 0.00150124 0.00590538
Brugia malayi Melatonin receptor type 1A 0.00436326 0.0707623 0.108582
Schistosoma mansoni neuropeptide receptor 0.00436326 0.0707623 0.15993
Schistosoma mansoni acetylcholine receptor-related 0.00183333 0.0176118 0.0398045
Loa Loa (eye worm) ACC-1 protein 0.00397445 0.062594 0.062594
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00436326 0.0707623 0.278355
Brugia malayi follicle stimulating hormone receptor 0.00436326 0.0707623 0.108582
Loa Loa (eye worm) hypothetical protein 0.00164428 0.0136399 0.0136399
Echinococcus granulosus hypothetical protein 0.00436326 0.0707623 0.278355
Echinococcus granulosus rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.00397445 0.062594 0.246224
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.00397445 0.062594 0.062594
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Entamoeba histolytica cysteine proteinase 1, putative 0.00188629 0.0187244 0.405405
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Schistosoma mansoni neurotransmitter gated ion channel 0.00183333 0.0176118 0.0398045
Schistosoma mansoni dynamin 0.00147805 0.0101478 0.0229351
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018915 0.0188339 0.0288998
Echinococcus multilocularis cathepsin b 0.0130955 0.254216 1
Loa Loa (eye worm) hypothetical protein 0.00230221 0.0274624 0.0274624
Brugia malayi Glutamate receptor 2 precursor 0.00339301 0.0503787 0.077304
Plasmodium vivax dynamin-like protein, putative 0.001373 0.00794076 0.171927
Brugia malayi Cathepsin L-like precursor 0.00319348 0.0461868 0.0708717
Echinococcus multilocularis nAChR subunit 0.00214112 0.024078 0.0947147
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni growth hormone secretagogue receptor 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Entamoeba histolytica cysteine proteinase, putative 0.00319348 0.0461868 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.00164428 0.0136399 0.0536549
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00164428 0.0136399 0.0308277
Echinococcus granulosus rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Echinococcus granulosus voltage gated potassium channel 0.00106648 0.00150124 0.00590538
Plasmodium vivax dynamin protein, putative 0.001373 0.00794076 0.171927
Brugia malayi Cathepsin L-like precursor 0.00319348 0.0461868 0.0708717
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Echinococcus multilocularis glutamate receptor 2 0.00213741 0.024 0.0944077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Echinococcus multilocularis neuropeptide FF receptor 2 0.00436326 0.0707623 0.278355
Echinococcus granulosus dynamin 1 0.00147805 0.0101478 0.039918
Loa Loa (eye worm) norepinephrine transporter 0.00968628 0.182592 0.182592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00230221 0.0274624 0.262745
Loa Loa (eye worm) hypothetical protein 0.0114958 0.220609 0.220609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Echinococcus multilocularis rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00436326 0.0707623 0.15993
Echinococcus granulosus dynamin 0.001373 0.00794076 0.0312363
Echinococcus granulosus neuropeptides capa receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Schistosoma mansoni nAChR subunit 0.00397445 0.062594 0.141469
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Onchocerca volvulus Cathepsin F homolog 0.00319348 0.0461868 0.209361
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00436326 0.0707623 0.0707623
Echinococcus granulosus cathepsin l1 0.00319348 0.0461868 0.181683
Schistosoma mansoni neuropeptide receptor 0.00436326 0.0707623 0.15993
Schistosoma mansoni amine GPCR 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00436326 0.0707623 0.15993
Echinococcus multilocularis glycine receptor subunit beta 0.00397445 0.062594 0.246224
Schistosoma mansoni alpha-1 adrenergic receptor 0.00436326 0.0707623 0.15993
Onchocerca volvulus 0.0114958 0.220609 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.00183333 0.0176118 0.0692789
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Echinococcus granulosus rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0018915 0.0188339 0.0740862
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.00183333 0.0176118 0.0270246
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00436326 0.0707623 0.278355
Plasmodium vivax vivapain-2 0.00319348 0.0461868 1
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00164428 0.0136399 0.0308277
Schistosoma mansoni voltage-gated potassium channel 0.00106648 0.00150124 0.00339296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0114958 0.220609 0.338515
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00436326 0.0707623 0.108582
Loa Loa (eye worm) hypothetical protein 0.00127248 0.0058289 0.0058289
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00106648 0.00150124 0.00590538
Schistosoma mansoni cathepsin F (C01 family) 0.00319348 0.0461868 0.104387
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.00397445 0.062594 0.062594
Loa Loa (eye worm) hypothetical protein 0.0485943 1 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018915 0.0188339 0.0425666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00436326 0.0707623 0.0707623
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.0187244 0.405405
Loa Loa (eye worm) hypothetical protein 0.0485943 1 1
Schistosoma mansoni neuropeptide receptor 0.00436326 0.0707623 0.15993
Schistosoma mansoni glutamate receptor NMDA 0.00339301 0.0503787 0.113861
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00164428 0.0136399 0.0308277
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.00183333 0.0176118 0.0692789
Onchocerca volvulus 0.00214112 0.024078 0.109144
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.00397445 0.062594 0.141469
Echinococcus multilocularis sodium and chloride dependent glycine 0.00164428 0.0136399 0.0536549
Echinococcus granulosus neuropeptide Y receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.00397445 0.062594 0.246224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Echinococcus multilocularis rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018915 0.0188339 0.0740862
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Brugia malayi sulfakinin receptor protein 0.00436326 0.0707623 0.108582
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Brugia malayi hypothetical protein 0.00183333 0.0176118 0.0270246
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00339301 0.0503787 0.198173
Echinococcus multilocularis neuropeptides capa receptor 0.00436326 0.0707623 0.278355
Echinococcus granulosus neuropeptide s receptor 0.00436326 0.0707623 0.278355
Plasmodium vivax amine transporter, putative 0.00164428 0.0136399 0.295321
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni nAChR subunit 0.00397445 0.062594 0.141469
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00164428 0.0136399 0.130499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Echinococcus multilocularis neuropeptides capa receptor 0.00436326 0.0707623 0.278355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.0187244 0.405405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 0.254216 0.574555
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0114958 0.220609 0.867799
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.00125561 0.00547447 0.0215347
Mycobacterium tuberculosis Carboxylesterase LipT 0.00127248 0.0058289 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00397445 0.062594 0.096048
Echinococcus granulosus neuropeptide receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00214112 0.024078 0.024078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.00597015 0.104521 0.411151
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.00214112 0.024078 0.0369467
Echinococcus multilocularis dynamin 0.001373 0.00794076 0.0312363
Entamoeba histolytica hypothetical protein 0.00214112 0.024078 0.521318
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00436326 0.0707623 0.108582
Echinococcus multilocularis neuropeptide Y receptor 0.00436326 0.0707623 0.278355
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00397445 0.062594 0.096048
Brugia malayi Serotonin receptor 0.00436326 0.0707623 0.108582
Brugia malayi Carboxylesterase family protein 0.00127248 0.0058289 0.0089442
Toxoplasma gondii hypothetical protein 0.00164428 0.0136399 0.130499
Loa Loa (eye worm) solute carrier family 6 member 4 0.00968628 0.182592 0.182592
Echinococcus multilocularis serotonin receptor 0.00436326 0.0707623 0.278355
Brugia malayi RE15519p 0.00436326 0.0707623 0.108582
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.00164428 0.0136399 0.0536549
Plasmodium vivax unspecified product 0.00188629 0.0187244 0.405405
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Loa Loa (eye worm) hypothetical protein 0.00968628 0.182592 0.182592
Echinococcus multilocularis G protein coupled receptor 139 0.00436326 0.0707623 0.278355
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00597015 0.104521 0.236229
Echinococcus multilocularis rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Brugia malayi neuropeptide F receptor 0.00436326 0.0707623 0.108582
Brugia malayi larval opioid receptor 0.00436326 0.0707623 0.108582
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.00214112 0.024078 0.0544188
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Treponema pallidum sodium- and chloride- dependent transporter 0.00968628 0.182592 0.5
Echinococcus granulosus fmrfamide receptor 0.00436326 0.0707623 0.278355
Brugia malayi hypothetical protein 0.00183333 0.0176118 0.0270246
Schistosoma mansoni glutamate receptor kainate 0.00339301 0.0503787 0.113861
Toxoplasma gondii cathepsin B 0.00597015 0.104521 1
Echinococcus multilocularis glutamate receptor 2 0.00339301 0.0503787 0.198173
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.00397445 0.062594 0.096048
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Brugia malayi hypothetical protein 0.00127248 0.0058289 0.0089442
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00319348 0.0461868 0.181683
Trypanosoma cruzi cysteine proteinase, putative 0.00188629 0.0187244 0.0736553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Brugia malayi putative neuropeptide receptor 0.00436326 0.0707623 0.108582
Echinococcus granulosus glycine receptor subunit alpha 1 0.00397445 0.062594 0.246224
Loa Loa (eye worm) neuropeptide F receptor 0.00436326 0.0707623 0.0707623
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00319348 0.0461868 0.441889
Plasmodium falciparum dynamin-like protein 0.001373 0.00794076 0.171927
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Brugia malayi Dopamine receptor 0.00436326 0.0707623 0.108582
Echinococcus multilocularis serotonin receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni voltage-gated potassium channel 0.00359661 0.0546561 0.123529
Echinococcus multilocularis dynamin 1 protein 0.001373 0.00794076 0.0312363
Brugia malayi Cathepsin L-like precursor 0.00319348 0.0461868 0.0708717
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Plasmodium vivax vivapain-3 0.00188629 0.0187244 0.405405
Schistosoma mansoni acetylcholine receptor subunit beta 0.00183333 0.0176118 0.0398045
Brugia malayi Dopamine receptor protein 1 0.0320152 0.651695 1
Trichomonas vaginalis mgm1, putative 0.001373 0.00794076 0.0759728
Loa Loa (eye worm) LGC-31 protein 0.00397445 0.062594 0.062594
Echinococcus granulosus tachykinin peptides receptor 99D 0.00436326 0.0707623 0.278355
Brugia malayi hypothetical protein 0.00183333 0.0176118 0.0270246
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.00397445 0.062594 0.141469
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00319348 0.0461868 0.0461868
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.00397445 0.062594 0.096048
Brugia malayi Cation transporter family protein 0.00397445 0.062594 0.096048
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Onchocerca volvulus 0.00397445 0.062594 0.283733
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0018915 0.0188339 0.0288998
Echinococcus granulosus acetylcholinesterase 0.00753098 0.137312 0.54014
Brugia malayi Glutamate receptor 1 precursor 0.00339301 0.0503787 0.077304
Echinococcus multilocularis glycine receptor subunit beta 0.00397445 0.062594 0.246224
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0114958 0.220609 0.867799
Loa Loa (eye worm) hypothetical protein 0.00164428 0.0136399 0.0136399
Loa Loa (eye worm) hypothetical protein 0.00164428 0.0136399 0.0136399
Loa Loa (eye worm) hypothetical protein 0.00214112 0.024078 0.024078
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00339301 0.0503787 0.198173
Echinococcus granulosus biogenic amine 5HT receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00436326 0.0707623 0.15993
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0018915 0.0188339 0.180192
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00397445 0.062594 0.096048
Echinococcus granulosus sodium and chloride dependent glycine 0.00164428 0.0136399 0.0536549
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Echinococcus multilocularis somatostatin receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00127248 0.0058289 0.0058289
Echinococcus granulosus rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.0461868 0.181683
Trichomonas vaginalis dynamin, putative 0.001373 0.00794076 0.0759728
Onchocerca volvulus 0.00183333 0.0176118 0.0798329
Loa Loa (eye worm) hypothetical protein 0.00127248 0.0058289 0.0058289
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00436326 0.0707623 0.15993
Schistosoma mansoni neuropeptide receptor 0.00436326 0.0707623 0.15993
Trypanosoma cruzi dynamin-1-like protein 0.001373 0.00794076 0.0312363
Echinococcus multilocularis nmda type glutamate receptor 0.00125561 0.00547447 0.0215347
Trichomonas vaginalis dynamin, putative 0.001373 0.00794076 0.0759728
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00436326 0.0707623 0.278355
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.001373 0.00794076 0.0759728
Schistosoma mansoni biogenic amine receptor 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Brugia malayi cathepsin B-like cysteine proteinase 0.0130955 0.254216 0.390084
Toxoplasma gondii dynamin-related protein DRPA 0.001373 0.00794076 0.0759728
Echinococcus granulosus tm gpcr rhodopsin 0.00436326 0.0707623 0.278355
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.00339301 0.0503787 0.198173
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00326218 0.0476301 0.0476301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.00397445 0.062594 0.246224
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00214112 0.024078 0.0369467
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus cathepsin l cysteine peptidase 0.00319348 0.0461868 0.181683
Brugia malayi G protein-coupled receptor 0.00436326 0.0707623 0.108582
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Echinococcus multilocularis neuropeptide s receptor 0.00436326 0.0707623 0.278355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00183333 0.0176118 0.0270246
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00436326 0.0707623 0.278355
Onchocerca volvulus Cathepsin L homolog 0.00319348 0.0461868 0.209361
Brugia malayi Carboxylesterase family protein 0.00753098 0.137312 0.2107
Echinococcus multilocularis rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00214112 0.024078 0.024078
Echinococcus multilocularis serotonin transporter 0.00968628 0.182592 0.718256
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Trichomonas vaginalis dynamin, putative 0.001373 0.00794076 0.0759728
Onchocerca volvulus Cathepsin L homolog 0.00319348 0.0461868 0.209361
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00326218 0.0476301 0.0730864
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.00127248 0.0058289 0.5
Schistosoma mansoni adenoreceptor 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.00279977 0.0379153 0.0379153
Echinococcus granulosus dro:myosuppressin receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni acetylcholinesterase 0.00127248 0.0058289 0.0131739
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.00319348 0.0461868 0.0461868
Echinococcus multilocularis rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Echinococcus granulosus family S9 non peptidase ue S09 family 0.00127248 0.0058289 0.0229289
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.0187244 0.042319
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0114958 0.220609 0.867799
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.00183333 0.0176118 0.0176118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Echinococcus granulosus rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Onchocerca volvulus 0.00127248 0.0058289 0.0264219
Echinococcus multilocularis cathepsin b 0.0130955 0.254216 1
Onchocerca volvulus 0.0114958 0.220609 1
Loa Loa (eye worm) TYRA-2 protein 0.00436326 0.0707623 0.0707623
Plasmodium falciparum cysteine proteinase falcipain 3 0.00319348 0.0461868 1
Onchocerca volvulus 0.00968628 0.182592 0.827675
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Brugia malayi Serotonin receptor 0.00436326 0.0707623 0.108582
Echinococcus multilocularis g protein coupled receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni histamine h1 receptor 0.00436326 0.0707623 0.15993
Toxoplasma gondii hypothetical protein 0.00164428 0.0136399 0.130499
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00164428 0.0136399 0.130499
Brugia malayi GnHR receptor homolog 0.00436326 0.0707623 0.108582
Brugia malayi Cathepsin L-like precursor 0.00230221 0.0274624 0.04214
Schistosoma mansoni amine GPCR 0.0220557 0.442457 1
Echinococcus granulosus glutamate receptor 2 0.00213741 0.024 0.0944077
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.00339301 0.0503787 0.198173
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus g protein coupled receptor 0.00436326 0.0707623 0.278355
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.00397445 0.062594 0.246224
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.0461868 0.181683
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.00188629 0.0187244 0.0736553
Leishmania major cathepsin L-like protease 0.00319348 0.0461868 0.396002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00436326 0.0707623 0.108582
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Echinococcus multilocularis glycine receptor subunit alpha 1 0.00397445 0.062594 0.246224
Echinococcus granulosus cathepsin L cysteine proteinase 0.00319348 0.0461868 0.181683
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.0187244 0.042319
Echinococcus granulosus biogenic amine 5HT receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus G protein coupled receptor 139 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) carboxylesterase 0.00753098 0.137312 0.137312
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00164428 0.0136399 0.130499
Entamoeba histolytica cysteine proteinase 2 0.00188629 0.0187244 0.405405
Brugia malayi Dynamin 0.00147805 0.0101478 0.0155714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00188629 0.0187244 0.179144
Schistosoma mansoni ATP-binding cassette transporter 0.00339301 0.0503787 0.113861
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00106648 0.00150124 0.00590538
Brugia malayi AKH receptor 0.00436326 0.0707623 0.108582
Echinococcus granulosus acetylcholinesterase 0.00753098 0.137312 0.54014
Loa Loa (eye worm) carboxylesterase 0.00127248 0.0058289 0.0058289
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00164428 0.0136399 0.0308277
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0114958 0.220609 0.867799
Schistosoma mansoni gliotactin 0.00127248 0.0058289 0.0131739
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00164428 0.0136399 0.0536549
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.00597015 0.104521 1
Schistosoma mansoni amine GPCR 0.00436326 0.0707623 0.15993
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00326218 0.0476301 0.187361
Schistosoma mansoni glutamate receptor AMPA 0.00339301 0.0503787 0.113861
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0114958 0.220609 0.220609
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00397445 0.062594 0.096048
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00164428 0.0136399 0.0308277
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0114958 0.220609 0.867799
Echinococcus granulosus 7TM GPCR rhodopsin 0.00436326 0.0707623 0.278355
Leishmania major cysteine peptidase A (CPA) 0.00319348 0.0461868 0.396002
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Onchocerca volvulus 0.00397445 0.062594 0.283733
Brugia malayi hypothetical protein 0.00164428 0.0136399 0.0209299
Schistosoma mansoni biogenic amine (5HT) receptor 0.00436326 0.0707623 0.15993
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00106648 0.00150124 0.00230359
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Onchocerca volvulus 0.00127248 0.0058289 0.0264219
Echinococcus multilocularis dro:myosuppressin receptor 0.00436326 0.0707623 0.278355
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00164428 0.0136399 0.0536549
Echinococcus multilocularis rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Schistosoma mansoni nAChR subunit 0.00183333 0.0176118 0.0398045
Loa Loa (eye worm) hypothetical protein 0.00230221 0.0274624 0.0274624
Loa Loa (eye worm) hypothetical protein 0.00214112 0.024078 0.024078
Echinococcus multilocularis rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00127248 0.0058289 0.0131739
Schistosoma mansoni hypothetical protein 0.00436326 0.0707623 0.15993
Onchocerca volvulus 0.0114958 0.220609 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00436326 0.0707623 0.108582
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Echinococcus multilocularis glutamate receptor 2 0.00339301 0.0503787 0.198173
Onchocerca volvulus 0.00127248 0.0058289 0.0264219
Echinococcus granulosus g protein coupled receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00155009 0.0116612 0.0116612
Echinococcus granulosus tm gpcr rhodopsin 0.00436326 0.0707623 0.278355
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Onchocerca volvulus 0.00183333 0.0176118 0.0798329
Leishmania major cathepsin L-like protease 0.00319348 0.0461868 0.396002
Schistosoma mansoni neuropeptide f receptor 76f 0.00436326 0.0707623 0.15993
Plasmodium falciparum cysteine proteinase falcipain 2b 0.00319348 0.0461868 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Loa Loa (eye worm) hypothetical protein 0.00397445 0.062594 0.062594
Loa Loa (eye worm) hypothetical protein 0.0018915 0.0188339 0.0188339
Loa Loa (eye worm) acetylcholinesterase 1 0.00753098 0.137312 0.137312
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.00214112 0.024078 0.0369467
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018915 0.0188339 0.0740862
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00436326 0.0707623 0.0707623
Echinococcus multilocularis fmrfamide receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.00397445 0.062594 0.062594
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00183333 0.0176118 0.0270246
Brugia malayi Papain family cysteine protease containing protein 0.00319348 0.0461868 0.0708717
Trypanosoma cruzi cysteine protease, putative 0.00188629 0.0187244 0.0736553
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00436326 0.0707623 0.278355
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Echinococcus multilocularis dynamin 1 0.00147805 0.0101478 0.039918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00753098 0.137312 0.31034
Echinococcus granulosus para nitrobenzyl esterase 0.00127248 0.0058289 0.0229289
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00436326 0.0707623 0.278355
Brugia malayi ORL1-like opioid receptor 0.00436326 0.0707623 0.108582
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.0187244 0.405405
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00319348 0.0461868 0.181683
Brugia malayi Cation transporter family protein 0.0114958 0.220609 0.338515
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Loa Loa (eye worm) hypothetical protein 0.00147805 0.0101478 0.0101478
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0130955 0.254216 1
Echinococcus granulosus cathepsin l1 0.00230221 0.0274624 0.108028
Loa Loa (eye worm) ctsf protein 0.00319348 0.0461868 0.0461868
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.00230221 0.0274624 0.108028
Echinococcus multilocularis nAChR subunit 0.00397445 0.062594 0.246224
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00214112 0.024078 0.0369467
Echinococcus multilocularis acetylcholinesterase 0.00753098 0.137312 0.54014
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00436326 0.0707623 0.15993
Brugia malayi Dopamine receptor protein 2 0.00436326 0.0707623 0.108582
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00436326 0.0707623 0.278355
Schistosoma mansoni biogenic amine receptor 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0130955 0.254216 0.574555
Echinococcus multilocularis cysteine protease 0.00319348 0.0461868 0.181683
Schistosoma mansoni dynamin 0.001373 0.00794076 0.0179469
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.00397445 0.062594 0.246224
Trypanosoma brucei cysteine peptidase C (CPC) 0.00597015 0.104521 1
Echinococcus granulosus g protein coupled receptor 0.00436326 0.0707623 0.278355
Echinococcus multilocularis cathepsin L cysteine protease 0.00319348 0.0461868 0.181683
Echinococcus multilocularis BC026374 protein (S09 family) 0.00127248 0.0058289 0.0229289
Echinococcus granulosus neuropeptides capa receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00436326 0.0707623 0.15993
Schistosoma mansoni hypothetical protein 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) neuropeptide F receptor 0.00436326 0.0707623 0.0707623
Echinococcus granulosus alpha 1A adrenergic receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus carboxylesterase 5A 0.00753098 0.137312 0.54014
Loa Loa (eye worm) hypothetical protein 0.00966249 0.182093 0.182093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.0461868 0.396002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 0.254216 0.574555
Onchocerca volvulus 0.00319348 0.0461868 0.209361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Schistosoma mansoni glutamate receptor NMDA 0.00339301 0.0503787 0.113861
Loa Loa (eye worm) serotonin transporter b 0.00968628 0.182592 0.182592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Echinococcus multilocularis g-protein coupled receptor 0.00436326 0.0707623 0.278355
Echinococcus granulosus cathepsin b 0.0130955 0.254216 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00436326 0.0707623 0.15993
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.00183333 0.0176118 0.0692789
Loa Loa (eye worm) hypothetical protein 0.00127248 0.0058289 0.0058289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Brugia malayi Carboxylesterase family protein 0.00753098 0.137312 0.2107
Brugia malayi Dynamin central region family protein 0.001373 0.00794076 0.0121848
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Trichomonas vaginalis dynamin, putative 0.001373 0.00794076 0.0759728
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00436326 0.0707623 0.278355
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00319348 0.0461868 0.0461868
Schistosoma mansoni sodium/chloride dependent transporter 0.00164428 0.0136399 0.0308277
Echinococcus granulosus nAChR subunit 0.00397445 0.062594 0.246224
Onchocerca volvulus 0.00164428 0.0136399 0.0618287
Echinococcus granulosus sex peptide receptor 0.00436326 0.0707623 0.278355
Toxoplasma gondii cathepsin CPL 0.00319348 0.0461868 0.441889
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.00164428 0.0136399 0.0536549
Onchocerca volvulus 0.00127248 0.0058289 0.0264219
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00183333 0.0176118 0.0176118
Giardia lamblia Cathepsin B precursor 0.00597015 0.104521 1
Brugia malayi G protein-coupled receptor F59B2.13 0.00436326 0.0707623 0.108582
Echinococcus granulosus glycine receptor subunit beta 0.00397445 0.062594 0.246224
Echinococcus multilocularis cathepsin L 0.00188629 0.0187244 0.0736553
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Echinococcus granulosus allatostatin A receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00436326 0.0707623 0.15993
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00339301 0.0503787 0.198173
Leishmania major cathepsin L-like protease 0.00319348 0.0461868 0.396002
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.00397445 0.062594 0.246224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Schistosoma mansoni glutamate receptor AMPA 0.00339301 0.0503787 0.113861
Echinococcus multilocularis carboxylesterase 5A 0.00753098 0.137312 0.54014
Brugia malayi Cathepsin L-like cysteine proteinase 0.00230221 0.0274624 0.04214
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00299254 0.0419654 0.401501
Plasmodium falciparum cysteine proteinase falcipain 1 0.00188629 0.0187244 0.405405
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.00397445 0.062594 0.096048
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Echinococcus granulosus BC026374 protein S09 family 0.00127248 0.0058289 0.0229289
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018915 0.0188339 0.180192
Echinococcus multilocularis allatostatin A receptor 0.00436326 0.0707623 0.278355
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018915 0.0188339 0.0740862
Schistosoma mansoni amine GPCR 0.00436326 0.0707623 0.15993
Trypanosoma cruzi cruzipain precursor, putative 0.00319348 0.0461868 0.181683
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.00125561 0.00547447 0.0215347
Loa Loa (eye worm) acetylcholine receptor protein 0.00183333 0.0176118 0.0176118
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00436326 0.0707623 0.15993
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00436326 0.0707623 0.278355
Echinococcus granulosus glycine receptor subunit alpha 1 0.00397445 0.062594 0.246224
Brugia malayi Carboxylesterase family protein 0.00127248 0.0058289 0.0089442
Leishmania major cathepsin L-like protease 0.00319348 0.0461868 0.396002
Echinococcus granulosus neuropeptide Y receptor 0.00436326 0.0707623 0.278355
Giardia lamblia Dynamin 0.001373 0.00794076 0.0759728
Echinococcus multilocularis neuropeptide receptor 0.00436326 0.0707623 0.278355
Echinococcus granulosus serotonin receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) hypothetical protein 0.0018915 0.0188339 0.0188339
Echinococcus granulosus glutamate NMDA receptor subunit 0.00339301 0.0503787 0.198173
Echinococcus multilocularis NMDA receptor 0.00125561 0.00547447 0.0215347
Onchocerca volvulus 0.00319348 0.0461868 0.209361
Loa Loa (eye worm) fibroinase 0.00319348 0.0461868 0.0461868
Mycobacterium ulcerans carboxylesterase, LipT 0.00127248 0.0058289 0.5
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.00397445 0.062594 0.062594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.0461868 0.441889
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni sodium-dependent amino acid transporter 0.00164428 0.0136399 0.0308277
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.00397445 0.062594 0.096048
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.00125561 0.00547447 0.0215347
Leishmania major cathepsin L-like protease 0.00319348 0.0461868 0.396002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00188629 0.0187244 0.179144
Echinococcus multilocularis cathepsin L cysteine protease 0.00319348 0.0461868 0.181683
Schistosoma mansoni hypothetical protein 0.00436326 0.0707623 0.15993
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.0461868 0.441889
Echinococcus multilocularis rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Brugia malayi Cation transporter family protein 0.00397445 0.062594 0.096048
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00436326 0.0707623 0.15993
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00968628 0.182592 0.28018
Loa Loa (eye worm) hypothetical protein 0.00164428 0.0136399 0.0136399
Giardia lamblia Cathepsin B precursor 0.00597015 0.104521 1
Leishmania major cathepsin L-like protease 0.00319348 0.0461868 0.396002
Entamoeba histolytica cysteine proteinase, putative 0.00319348 0.0461868 1
Loa Loa (eye worm) hypothetical protein 0.00753098 0.137312 0.137312
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018915 0.0188339 0.0740862
Plasmodium falciparum transporter, putative 0.00164428 0.0136399 0.295321
Echinococcus granulosus glutamate receptor ionotropic kainate 0.00125561 0.00547447 0.0215347
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.00339301 0.0503787 0.198173
Loa Loa (eye worm) hypothetical protein 0.00106648 0.00150124 0.00150124
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0018915 0.0188339 0.0188339
Schistosoma mansoni opsin-like receptor 0.00436326 0.0707623 0.15993
Echinococcus granulosus rhodopsin orphan GPCR 0.00436326 0.0707623 0.278355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00397445 0.062594 0.096048
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00436326 0.0707623 0.32076
Echinococcus granulosus dynamin 1 protein 0.001373 0.00794076 0.0312363
Schistosoma mansoni neuropeptide F-like receptor 0.00436326 0.0707623 0.15993
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00436326 0.0707623 0.0707623
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00397445 0.062594 0.096048
Onchocerca volvulus 0.00436326 0.0707623 0.32076
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00436326 0.0707623 0.278355
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00319348 0.0461868 0.441889
Brugia malayi hypothetical protein 0.00183333 0.0176118 0.0270246
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) cysteine protease 0.00319348 0.0461868 0.0461868
Echinococcus multilocularis fmrfamide receptor 0.00436326 0.0707623 0.278355
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0114958 0.220609 0.498598
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Brugia malayi hypothetical protein 0.00436326 0.0707623 0.108582
Schistosoma mansoni hypothetical protein 0.00436326 0.0707623 0.15993
Entamoeba histolytica dynamin-like protein 0.001373 0.00794076 0.171927
Loa Loa (eye worm) hypothetical protein 0.00968628 0.182592 0.182592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00230221 0.0274624 0.262745
Entamoeba histolytica cysteine protease, putative 0.00188629 0.0187244 0.405405
Loa Loa (eye worm) hypothetical protein 0.00753098 0.137312 0.137312
Onchocerca volvulus 0.00164428 0.0136399 0.0618287
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00164428 0.0136399 0.0136399
Loa Loa (eye worm) melatonin receptor type 1A 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Loa Loa (eye worm) hypothetical protein 0.00436326 0.0707623 0.0707623
Onchocerca volvulus 0.00164428 0.0136399 0.0618287

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 3.7 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18420405
EC50 (functional) = 3.7 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18420405
EC50 (functional) > 30 uM Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 infected human O+ erythrocytes by DNA stain without pepstatin ChEMBL. 19447616
IC50 (binding) = 0.021 uM Inhibition of human cathepsin L ChEMBL. 18420405
IC50 (binding) = 0.021 uM Inhibition of human cathepsin L ChEMBL. 18420405
IC50 (binding) = 0.042 uM Inhibition of Trypanosoma brucei rhodesain ChEMBL. 18420405
IC50 (binding) = 6 uM Inhibition of human cathepsin B ChEMBL. 18420405
IC50 (binding) = 6 uM Inhibition of human cathepsin B ChEMBL. 18420405
IC50 (binding) > 25 uM Inhibition of Trypanosoma brucei cathepsin B ChEMBL. 18420405
Ratio EC50 (functional) > 6.7 Therapeutic index, ratio of EC50 for human Raji cells to EC50 for Trypanosoma brucei ChEMBL. 18420405

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 18420405
Trypanosoma brucei ChEMBL23 18420405

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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