Detailed information for compound 511431

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.757 | Formula: C19H10ClF3N4O2
  • H donors: 2 H acceptors: 4 LogP: 4.36 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClC1=C(Nc2ccc(cc2)C(F)(F)F)C(=O)c2c(C1=O)nc([nH]2)c1ccccn1
  • InChi: 1S/C19H10ClF3N4O2/c20-12-13(25-10-6-4-9(5-7-10)19(21,22)23)17(29)15-14(16(12)28)26-18(27-15)11-3-1-2-8-24-11/h1-8,25H,(H,26,27)
  • InChiKey: JSODHLOLUCEXKH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0807 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0076 0.112 0.1079
Plasmodium vivax CDK-related protein kinase 6, putative 0.0451 0.8325 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0039 0.0407 0.4777
Brugia malayi Cam kinase protein 1 0.0033 0.0285 0.024
Echinococcus multilocularis potassium voltage gated channel protein 0.0022 0.0081 0.0036
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0022 0.0081 0.0036
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.067 0.0627
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Leishmania major glucose transporter, lmgt1 0.0033 0.0287 0.1477
Leishmania major cytochrome p450-like protein 0.0039 0.0407 0.2336
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0285 0.0381
Echinococcus multilocularis 0.0039 0.0407 0.0363
Entamoeba histolytica protein kinase, putative 0.0033 0.0285 0.1284
Echinococcus granulosus short transient receptor potential channel 6 0.0022 0.0081 0.0036
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0081 0.0036
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0287 0.0852
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0022 0.0081 0.0036
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0285 0.024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0152 0.0106
Loa Loa (eye worm) voltage-gated potassium channel 0.0022 0.0081 0.0036
Toxoplasma gondii hypothetical protein 0.0054 0.0693 0.1143
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0081 0.0036
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0039 0.0407 0.4263
Echinococcus multilocularis ryanodine receptor 44f 0.0022 0.0082 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1475 0.8655
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0222
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1696 0.1657
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0039 0.0407 0.4777
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0222
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0039 0.0407 0.4263
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0081 0.0036
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0285 0.0289
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0594 0.0551
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0285 0.024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0081 0.0036
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0039 0.0407 0.4263
Schistosoma mansoni hypothetical protein 0.0039 0.0407 0.0363
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0081 0.0036
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0022 0.0081 0.0036
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0743 0.9087
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0368 0.0389
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0022 0.0081 0.0036
Echinococcus granulosus short transient receptor potential channel 6 0.0022 0.0081 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0594 0.0551
Echinococcus multilocularis potassium voltage gated channel protein 0.0022 0.0081 0.0036
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0039 0.0407 0.4777
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0039 0.0407 0.4263
Echinococcus granulosus hypothetical protein 0.0022 0.0081 0.0036
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.2959 0.3519
Schistosoma mansoni transient receptor potential channel 4 0.0022 0.0081 0.0036
Schistosoma mansoni glucose transport protein 0.0106 0.1696 0.1657
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.1696 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0022 0.0081 0.0036
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0039 0.0407 0.4263
Loa Loa (eye worm) sugar transporter 0.0106 0.1696 0.1657
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0368 0.1092
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0287 0.1477
Echinococcus granulosus potassium large conductance calcium activated 0.0022 0.0081 0.0036
Toxoplasma gondii transporter, cation channel family protein 0.0076 0.112 0.1943
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0285 0.0381
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0039 0.0407 0.4263
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0039 0.0407 0.4263
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0266 0.1149
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0081 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0039 0.0407 0.4777
Brugia malayi Cytochrome P450 family protein 0.0039 0.0407 0.0363
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0039 0.0407 0.4777
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.011 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0039 0.0407 0.4777
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0266 0.0222
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0266 0.1149
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1696 0.1657
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0266 0.0222
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0081 0.0036
Schistosoma mansoni protein kinase 0.0033 0.0285 0.024
Brugia malayi Cytochrome P450 family protein 0.0039 0.0407 0.0363
Plasmodium falciparum hexose transporter 0.0106 0.1696 0.1993
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0081 0.0036
Echinococcus multilocularis short transient receptor potential channel 6 0.0022 0.0081 0.0036
Leishmania major protein kinase, putative 0.0033 0.0285 0.1461
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.011 0.0086
Echinococcus granulosus voltage gated hydrogen channel 1 0.0022 0.0081 0.0036
Echinococcus granulosus two pore calcium channel protein 1 0.0022 0.0081 0.0036
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0115 0.1868 0.1831
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0285 0.024
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.024 0.0196
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0039 0.0407 0.4777
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0081 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0039 0.0407 0.4777
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.0064
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0039 0.0407 0.4777
Giardia lamblia Kinase, PLK 0.0095 0.1475 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0285 0.0289
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1475 0.8655
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0287 0.1423
Trypanosoma brucei glucose transporter, putative 0.0033 0.0287 0.0626
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0039 0.0407 0.4263
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1696 0.1657
Trypanosoma brucei glucose transporter, putative 0.0033 0.0287 0.0626
Echinococcus multilocularis conserved hypothetical protein 0.0022 0.0081 0.0036
Echinococcus granulosus ryanodine receptor 44f 0.0022 0.0082 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0297 0.0252
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.011 0.0064
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0022 0.0081 0.0241
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0081 0.0036
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0193 0.3371 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0022 0.0081 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1475 0.8655
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0807 0.0765
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0081 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0807 0.0765
Brugia malayi hypothetical protein 0.0022 0.0081 0.0036
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0287 0.0626
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Brugia malayi Cytochrome P450 family protein 0.0116 0.1882 0.1845
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0368 0.0389
Leishmania major glucose transporter, lmgt2 0.0033 0.0287 0.1477
Schistosoma mansoni voltage-dependent calcium channel 0.0022 0.0081 0.0036
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0407 0.1207
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0081 0.0036
Schistosoma mansoni lipoxygenase 0.0122 0.1998 0.1961
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1475 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0693 0.065
Echinococcus granulosus voltage dependent calcium channel 0.0076 0.112 0.1079
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0039 0.0407 0.4777
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0081 0.0036
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0081 0.0036
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0081 0.0036
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0743 0.0701
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0022 0.0081 0.0036
Schistosoma mansoni kinase 0.0049 0.0598 0.0555
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0743 0.9169
Schistosoma mansoni transient receptor potential channel 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0693 0.065
Schistosoma mansoni calcium-activated potassium channel 0.0022 0.0081 0.0036
Brugia malayi Sugar transporter family protein 0.0106 0.1696 0.1657
Loa Loa (eye worm) calcium channel 0.0538 1 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0266 0.0222
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0039 0.0407 0.4777
Trypanosoma brucei glucose transporter, putative 0.0033 0.0287 0.0626
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0081 0.0036
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.011 0.0064
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0039 0.0407 0.4263
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0575 0.3176
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0285 0.0381
Loa Loa (eye worm) voltage-gated potassium channel 0.0022 0.0081 0.0036
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0368 0.2057
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0022 0.0081 0.0036
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0022 0.0081 0.0036
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.011 0.0064
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0193 0.3371 1
Echinococcus multilocularis two pore calcium channel protein 1 0.0022 0.0081 0.0036
Echinococcus multilocularis short transient receptor potential channel 6 0.0022 0.0081 0.0036
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0081 0.0036
Toxoplasma gondii protein kinase, putative 0.03 0.5428 1
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0081 0.0036
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0039 0.0407 0.4263
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0039 0.0407 0.4777
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1696 0.1657
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0743 0.0701
Trypanosoma brucei polo-like protein kinase 0.0095 0.1475 0.4236
Brugia malayi cation channel family protein 0.0022 0.0081 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0407 0.0363
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0022 0.0081 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0266 0.6164
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0039 0.0407 0.4263
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0538 1 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0285 0.0289
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0285 0.024
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1475 0.8655
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0039 0.0407 0.4263
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0081 0.0036
Echinococcus granulosus TRP transient receptor potential channel 0.0022 0.0081 0.0036
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0285 0.024
Brugia malayi Cytochrome P450 family protein 0.0039 0.0407 0.0363
Echinococcus multilocularis General substrate transporter 0.0091 0.1409 0.1369
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0022 0.0081 0.0036
Leishmania major cytochrome p450-like protein 0.0039 0.0407 0.2336
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0285 0.0289
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0285 0.0289
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0407 0.1207
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0538 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1475 0.4375
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1475 0.8655
Echinococcus granulosus sodium channel protein 0.0022 0.0081 0.0036
Loa Loa (eye worm) ion channel NompC 0.0022 0.0081 0.0036
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0022 0.0081 0.0036
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0081 0.0036
Trypanosoma brucei glucose transporter 2A 0.0033 0.0287 0.0626
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0287 0.1423
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0081 0.0036
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.1696 0.1657
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0081 0.0036
Loa Loa (eye worm) voltage-gated calcium channel 0.0022 0.0081 0.0036
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1696 0.1657
Schistosoma mansoni glucose transport protein 0.0106 0.1696 0.1657
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0081 0.0036
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0538 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0538 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0081 0.0036
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0081 0.0036
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0266 0.0222
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0266 0.1297
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0287 0.0852
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0115 0.1868 0.1831
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0081 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.4257 0.423
Echinococcus multilocularis voltage dependent calcium channel 0.0538 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1475 0.8655
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.1696 0.1657
Onchocerca volvulus 0.0022 0.0081 0.0249
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0368 0.0871
Echinococcus granulosus shaker cognate 0.0022 0.0081 0.0036
Echinococcus granulosus calcium dependent protein kinase 0.003 0.024 0.0196
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0081 0.0036
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.011 0.0053
Schistosoma mansoni protein kinase 0.0033 0.0285 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0115 0.1868 0.1831
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Leishmania major cytochrome p450-like protein 0.0039 0.0407 0.2336
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0081 0.0036
Trypanosoma brucei glucose transporter, putative 0.0033 0.0287 0.0626
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0538 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0594 0.0551
Schistosoma mansoni transient receptor potential channel 0.0022 0.0081 0.0036
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1475 0.1436
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0039 0.0407 0.4263
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0807 0.5206
Echinococcus multilocularis potassium voltage gated channel protein 0.0022 0.0081 0.0036
Schistosoma mansoni hypothetical protein 0.0022 0.0081 0.0036
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0285 0.0289
Mycobacterium leprae putative cytochrome p450 0.0039 0.0407 1
Schistosoma mansoni hypothetical protein 0.0033 0.0297 0.0252
Echinococcus granulosus transient receptor potential gamma protein 0.0022 0.0081 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1475 0.8655
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0407 0.0363
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0285 0.0289
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0039 0.0407 0.4263
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1475 0.1436
Trypanosoma brucei glucose transporter, putative 0.0033 0.0287 0.0626
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0022 0.0082 0.0036
Schistosoma mansoni hypothetical protein 0.0106 0.1696 0.1657
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0081 0.0036
Schistosoma mansoni glucose transport protein 0.0106 0.1696 0.1657
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0407 0.0363
Schistosoma mansoni 60S ribosomal protein L21 0.0022 0.0081 0.0036
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0081 0.0036
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0081 0.0036
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0022 0.0081 0.0036
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0081 0.0036
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0407 0.1207
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0081 0.0036
Entamoeba histolytica protein kinase, putative 0.0033 0.0285 0.1284
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0287 0.1423
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0039 0.0407 0.4263
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0287 0.0852
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0807 0.0765
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0081 0.0036
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0081 0.0036
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0287 0.1423
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0139 0.2332 0.2297
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.011 0.5
Trypanosoma brucei glucose transporter, putative 0.0033 0.0287 0.0626
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0022 0.0081 0.0036
Loa Loa (eye worm) cytochrome P450 0.0039 0.0407 0.0363
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0807 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0368 0.1092
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0039 0.0407 0.4263
Echinococcus multilocularis sodium channel protein 0.0139 0.2332 0.2297
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0022 0.0081 0.0036
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0081 0.017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0297 0.0252
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0743 0.4749
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0081 0.0036
Loa Loa (eye worm) ryanodine receptor 0.0022 0.0081 0.0036
Mycobacterium leprae Conserved hypothetical protein 0.0039 0.0407 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0807 0.1357
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0807 0.0765
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0575 0.3176
Trypanosoma brucei glucose transporter, putative 0.0033 0.0287 0.0626
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1475 0.1436
Brugia malayi olfactory channel protein osm-9 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0076 0.112 0.1079
Schistosoma mansoni vesicular amine transporter 0.0022 0.0081 0.0036
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0743 0.0701
Brugia malayi lysyl-tRNA synthetase 0.0024 0.011 0.0064
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0081 0.0036
Echinococcus multilocularis shaker cognate 0.0022 0.0081 0.0036
Schistosoma mansoni lipoxygenase 0.0085 0.1292 0.1252
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0039 0.0407 0.4777
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0285 0.024
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0022 0.0081 0.0249
Plasmodium falciparum protein kinase 6 0.0451 0.8325 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0022 0.0081 0.0036
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0368 0.0536
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0022 0.0081 0.0036
Leishmania major glucose transporter, lmgt3 0.0033 0.0287 0.1477
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0039 0.0407 0.4777
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0039 0.0407 0.4777
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0022 0.0081 0.0036
Echinococcus multilocularis transfer RNA-Gly 0.0022 0.0081 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Schistosoma mansoni two-pore calcium channel 0.0022 0.0081 0.0036
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0287 0.0626
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0081 0.0036
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0285 0.024
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0407 0.1207
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0538 1 1
Schistosoma mansoni protein kinase 0.0033 0.0285 0.024
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0081 0.0036
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0022 0.0081 0.0036
Echinococcus multilocularis calcium activated potassium channel 0.0025 0.0126 0.0081
Trypanosoma brucei glucose transporter 1E 0.0033 0.0287 0.0626
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0285 0.0619
Echinococcus granulosus two pore calcium channel protein 2 0.0022 0.0081 0.0036
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0266 0.0222
Trypanosoma brucei glucose transporter, putative 0.0033 0.0287 0.0626
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Schistosoma mansoni voltage-gated cation channel 0.0538 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0081 0.0036
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0022 0.0081 0.0036
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0407 0.0989
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.0594 0.0551
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.0081 0.0036
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0538 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0039 0.0407 0.4777
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0287 0.1423
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0287 0.1423
Brugia malayi cation channel family protein 0.0022 0.0081 0.0036
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.1998 0.1961
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0538 1 1
Trypanosoma cruzi hexose transporter 0.0033 0.0287 0.0852
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0285 0.024
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1475 0.1436
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.2959 0.3519
Schistosoma mansoni voltage-gated ion channel 0.0022 0.0081 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0285 0.1409
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0022 0.0081 0.0036
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0285 0.024
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0039 0.0407 0.4777
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0039 0.0407 0.4777
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0081 0.0036
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0743 0.0701
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.011 0.0077
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.1882 0.1845
Echinococcus granulosus calcium activated potassium channel 0.0025 0.0126 0.0081
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0039 0.0407 0.4263
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0407 0.2336
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Echinococcus multilocularis two pore calcium channel protein 2 0.0022 0.0081 0.0036
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1475 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0115 0.1868 0.1831
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.011 0.1767 0.173
Brugia malayi cytochrome P450 0.0039 0.0407 0.0363
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0022 0.0081 0.0036
Plasmodium falciparum protein kinase 7 0.03 0.5428 0.6501
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.011 0.0077
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0407 0.4263
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.011 0.0064
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0081 0.0036
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.011 0.0325
Echinococcus granulosus sodium leak channel non selective protein 0.0022 0.0081 0.0036
Echinococcus granulosus General substrate transporter 0.0091 0.1409 0.1369
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0285 0.0289
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0266 0.0222
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0039 0.0407 0.4263
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0039 0.0407 0.4777
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0022 0.0081 0.0036
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1475 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0538 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0285 0.024
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.1696 0.1657
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.1696 0.3019
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0807 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0022 0.0081 0.0249
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0407 0.0609
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.011 0.1878
Brugia malayi ion channel NompC 0.0022 0.0081 0.0036
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0022 0.0081 0.0036
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1475 0.1436
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0081 0.0036
Plasmodium vivax hexose transporter 0.0106 0.1696 0.1993
Schistosoma mansoni transient receptor potential channel 0.0022 0.0081 0.0036
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0081 0.0036
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0285 0.0289
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0287 0.0626
Echinococcus granulosus potassium voltage gated channel protein 0.0022 0.0081 0.0036
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0039 0.0407 0.4263
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0807 1
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0538 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0743 0.9087
Echinococcus multilocularis potassium voltage gated channel protein 0.0022 0.0081 0.0036
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.1998 0.1961
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1475 0.4375
Echinococcus granulosus voltage dependent calcium channel 0.0538 1 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.011 0.0342
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0285 0.024
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.2959 0.5382
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0039 0.0407 0.4777
Echinococcus multilocularis transient receptor potential gamma protein 0.0022 0.0081 0.0036
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0039 0.0407 0.4263
Echinococcus multilocularis voltage dependent calcium channel 0.0538 1 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0368 0.2057
Schistosoma mansoni cytochrome P450 0.0039 0.0407 0.0363
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0022 0.0081 0.0036
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0407 0.0363
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0081 0.0036
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0081 0.017
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0407 0.0989
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0285 0.024
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0081 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0287 0.1423
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0022 0.0081 0.0036
Brugia malayi follicle stimulating hormone receptor 0.0239 0.4257 0.423
Brugia malayi Transient-receptor-potential like protein 0.0022 0.0081 0.0036
Schistosoma mansoni ryanodine receptor related 0.0022 0.0082 0.0036
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0407 0.1207
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0022 0.0081 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0285 0.024
Brugia malayi voltage-dependent calcium channel 0.0022 0.0081 0.0036
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0081 0.0036

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1 uM Antiproliferative activity against PDGF-induced rat aortic VSMC by colorimetric assay ChEMBL. 18400498

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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