Detailed information for compound 514669

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 477.637 | Formula: C33H35NO2
  • H donors: 0 H acceptors: 3 LogP: 4.92 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC2=C3[C@H](C[C@]4([C@H]([C@@H]3CCC2=C1)CC[C@@H]4C(=O)C1CC1)C)c1ccc(cc1)c1cccnc1
  • InChi: 1S/C33H35NO2/c1-33-18-28(21-6-4-20(5-7-21)24-3-2-16-34-19-24)31-26-13-11-25(35)17-23(26)10-12-27(31)29(33)14-15-30(33)32(36)22-8-9-22/h2-7,16-17,19,22,27-30H,8-15,18H2,1H3/t27-,28+,29-,30+,33-/m0/s1
  • InChiKey: NVYBWXHWNQURJF-JOJROWHISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens progesterone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dnaJ subfamily B 0.0411 0.1375 0.3957
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0605 0.204 0.8887
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0025 0.0284
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0326 0.1082 0.1714
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0331 1
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.0952 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0187 0.5648
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.008 0.0207
Brugia malayi hypothetical protein 0.0014 0.0014 0.0001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.002 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0082 0.0111
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0326 0.1082 0.1714
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0605 0.204 0.2035
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0605 0.204 0.3248
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0014 0.0016
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0456
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0082 0.0358
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0605 0.204 0.7383
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0331 0.2773
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0043 0.0486
Loa Loa (eye worm) hypothetical protein 0.0052 0.0143 0.0136
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0082 0.0358
Echinococcus multilocularis nAChR subunit 0.0605 0.204 0.7383
Echinococcus multilocularis dna polymerase kappa 0.006 0.0169 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0331 0.3387
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0014 0.0014 0.0021
Brugia malayi hypothetical protein 0.0036 0.0088 0.0121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0082 0.0269
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0169 0.166
Schistosoma mansoni rab6-interacting 0.0039 0.0097 0.0424
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0014 0.0014 0.0016
Brugia malayi nuclear receptor RXR 0.0018 0.0026 0.0022
Schistosoma mansoni glucose transport protein 0.0014 0.0014 0.006
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0082 0.0076
Echinococcus granulosus solute carrier family 5 0.0039 0.0097 0.0256
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0331 0.1175
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0082 0.0269
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0082 0.0358
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0082 0.0337
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0279 0.0922 0.1456
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0331 0.0325
Echinococcus multilocularis solute carrier family 22 0.0014 0.0014 0.0021
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0102 0.2036
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.008 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0548 0.5701
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.008 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0855 0.8966
Onchocerca volvulus 0.0082 0.0245 0.1141
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0082 0.0269
Brugia malayi hypothetical protein 0.0018 0.0026 0.0022
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0097 0.0321
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0025 0.0264
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0043 0.0486
Brugia malayi hypothetical protein 0.0279 0.0922 0.1456
Onchocerca volvulus 0.0039 0.0097 0.0409
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0326 0.1082 0.1714
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0082 0.0269
Loa Loa (eye worm) hypothetical protein 0.0082 0.0245 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0855 0.8966
Trypanosoma brucei glucose transporter, putative 0.0014 0.0014 0.0417
Schistosoma mansoni coup transcription factor 0.0034 0.0082 0.0358
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0014 0.0417
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Brugia malayi hypothetical protein 0.0014 0.0014 0.0001
Onchocerca volvulus 0.0279 0.0922 0.4481
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0082 0.0111
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0019
Echinococcus multilocularis protein dispatched 1 0.0048 0.013 0.0444
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0331 1
Giardia lamblia DINP protein human, muc B family 0.004 0.0102 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0082 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0548 0.5701
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0605 0.204 0.8887
Toxoplasma gondii facilitative glucose transporter GT1 0.0014 0.0014 0.0843
Schistosoma mansoni nuclear receptor 0.0016 0.002 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0082 0.0111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0088 0.0232
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0088 0.0291
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0108 0.1006
Mycobacterium ulcerans sugar transporter 0.0014 0.0014 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Schistosoma mansoni polycystin 1-related 0.0039 0.0097 0.0424
Trypanosoma brucei sugar transporter, putative 0.0014 0.0014 0.0417
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.0434
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.002 0.0086
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0014 0.1418
Schistosoma mansoni nAChR subunit 0.0605 0.204 0.8887
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.002 0.0042
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0279 0.0922 0.1456
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.008 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0046 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0082 0.0358
Trypanosoma brucei glucose transporter, putative 0.0014 0.0014 0.0417
Loa Loa (eye worm) hypothetical protein 0.0326 0.1082 0.1077
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0014 0.0417
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0076
Brugia malayi major facilitator superfamily protein 0.0014 0.0014 0.0001
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0097 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.058 0.6037
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0076
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0026 0.0053
Brugia malayi hypothetical protein 0.0039 0.0097 0.0135
Trypanosoma brucei glucose transporter, putative 0.0014 0.0014 0.0417
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0449 0.1603
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0097 0.0324
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.0147 0.4441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0082 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0952 1
Brugia malayi Doublecortin family protein 0.0039 0.0097 0.0135
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0097 0.0321
Brugia malayi Cation transporter family protein 0.0605 0.204 0.3248
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0022 0.0187
Toxoplasma gondii sugar transporter ST3 0.0014 0.0014 0.0843
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0046 0.0517
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0082 0.0358
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.008 0.026
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0043 0.1303
Echinococcus granulosus arachidonate 5 lipoxygenase 0.017 0.0549 0.1567
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0082 0.0337
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.002 0.0042
Loa Loa (eye worm) acetylcholine receptor protein 0.0279 0.0922 0.0916
Brugia malayi hypothetical protein 0.0018 0.0026 0.0022
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0055 0.0068
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0548 0.2639
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.002 0.0042
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0326 0.1082 0.4715
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.002
Brugia malayi 6-phosphofructokinase 0.0107 0.0331 0.051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Echinococcus granulosus Protein patched homolog 1 0.0042 0.011 0.0295
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0039
Brugia malayi ecdysone receptor 0.0016 0.002 0.0011
Trypanosoma brucei glucose transporter, putative 0.0014 0.0014 0.0417
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0097 0.0258
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.002 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.009 0.2711
Brugia malayi CHE-14 protein 0.0042 0.011 0.0155
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0279 0.0922 0.3319
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0014 0.0021
Schistosoma mansoni neurotransmitter gated ion channel 0.0279 0.0922 0.4015
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0097 0.0091
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0304 0.0466
Schistosoma mansoni acetylcholine receptor-related 0.0279 0.0922 0.4015
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0063 0.5859
Schistosoma mansoni lipoxygenase 0.0101 0.0309 0.1348
Schistosoma mansoni nAChR subunit 0.0605 0.204 0.8887
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0014 0.0014 0.0021
Schistosoma mansoni neurotransmitter gated ion channel 0.0279 0.0922 0.4015
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0043 0.2636
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0082 0.0111
Onchocerca volvulus 0.0605 0.204 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0082 0.0111
Schistosoma mansoni nAChR subunit 0.0605 0.204 0.8887
Schistosoma mansoni sugar transporter 0.0014 0.0014 0.006
Leishmania major glucose transporter, lmgt3 0.0014 0.0014 0.0417
Brugia malayi Sugar transporter family protein 0.0014 0.0014 0.0001
Brugia malayi phosphofructokinase 0.0107 0.0331 0.051
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0187 0.0181
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.002 0.0034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0082 0.0214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0082 0.0269
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0187 0.5648
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Brugia malayi Cation transporter family protein 0.0605 0.204 0.3248
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0082 0.0111
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0108 0.1006
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0046 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0082 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0026 0.0022
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0279 0.0922 0.2646
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0245 0.0686
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Onchocerca volvulus 0.0605 0.204 1
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.002 0.0011
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0097 0.0258
Echinococcus multilocularis muscleblind protein 1 0.015 0.0479 0.1712
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0187 0.5648
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0855 0.8966
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0548 0.5701
Onchocerca volvulus 0.0016 0.002 0.003
Schistosoma mansoni sugar transporter 0.0014 0.0014 0.006
Schistosoma mansoni sugar transporter 0.0014 0.0014 0.006
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0063 0.387
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Onchocerca volvulus 0.0605 0.204 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Brugia malayi hypothetical protein 0.0279 0.0922 0.1456
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.002 0.0011
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.002 0.003
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0014 0.0417
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0014 0.0417
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.2296 1
Echinococcus granulosus high affinity choline transporter 1 0.0039 0.0097 0.0256
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0456
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0046 0.0026
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0046 0.0742
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0331 0.7146
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0605 0.204 0.3248
Onchocerca volvulus 0.0024 0.0046 0.0158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0076
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0108 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0066 0.1994
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0952 1
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.002 0.0013
Toxoplasma gondii sugar transporter ST1 0.0014 0.0014 0.0843
Schistosoma mansoni hypothetical protein 0.0411 0.1375 0.5988
Onchocerca volvulus 0.0326 0.1082 0.5274
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.002 0.0042
Trypanosoma brucei glucose transporter, putative 0.0014 0.0014 0.0417
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0002
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0097 0.0256
Echinococcus granulosus glycine receptor subunit alpha 1 0.0605 0.204 0.5884
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0605 0.204 0.7383
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0014 0.0014 0.0016
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.0855 0.0849
Brugia malayi Sugar transporter family protein 0.0014 0.0014 0.0001
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0279 0.0922 0.0916
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0605 0.204 0.5884
Echinococcus granulosus solute carrier family 22 0.0014 0.0014 0.0016
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0063 0.6508
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0014 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0952 1
Giardia lamblia Sugar-proton symporter 0.0014 0.0014 0.0145
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.008 0.0107
Brugia malayi intermediate filament protein 0.0027 0.0055 0.0068
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0447 0.503
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0097 0.0256
Schistosoma mansoni patched 1 0.0042 0.011 0.0479
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.002 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0082 0.0076
Onchocerca volvulus 0.0605 0.204 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0082 0.0111
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0605 0.204 0.5884
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0046 0.0517
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0082 0.0214
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0063 0.0666
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0046 0.0026
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0082 0.0214
Trypanosoma brucei unspecified product 0.0023 0.0044 0.1321
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.002 0.0086
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0169 0.166
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0014 0.0417
Loa Loa (eye worm) hypothetical protein 0.1553 0.5297 0.5294
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0548 0.5701
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0605 0.204 0.7383
Echinococcus granulosus glycine receptor subunit beta 0.0605 0.204 0.5884
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0187 0.0519
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0169 0.5113
Loa Loa (eye worm) ACC-1 protein 0.0605 0.204 0.2035
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0605 0.204 0.7383
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0331 0.3173
Onchocerca volvulus 0.005 0.0135 0.0597
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0605 0.204 0.5884
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0605 0.204 0.2035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0082 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0102 0.3075
Schistosoma mansoni acetylcholine receptor subunit beta 0.0279 0.0922 0.4015
Brugia malayi CXXC zinc finger family protein 0.0029 0.0063 0.008
Plasmodium vivax sugar transporter, putative 0.0014 0.0014 0.1277
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.002 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0063 0.0529
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0014 0.0417
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0082 0.0358
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0082 0.0111
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0076
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.008 0.0351
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0102 0.3075
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0082 0.0358
Brugia malayi polk-prov protein 0.0037 0.009 0.0123
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0605 0.204 0.7383
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0548 0.5701
Giardia lamblia Hexose transporter 0.0014 0.0014 0.0145
Loa Loa (eye worm) hypothetical protein 0.015 0.0479 0.0473
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0019
Trypanosoma brucei unspecified product 0.0023 0.0044 0.1321
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0082 0.0358
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0046 0.0517
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.0952 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0076
Echinococcus multilocularis nAChR subunit 0.0326 0.1082 0.3904
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0855 0.8966
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0605 0.204 0.3248
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0026 0.002
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0454 0.1977
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0022 0.0187
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.017 0.0549 0.1966
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0331 0.3387
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0304 0.2506
Toxoplasma gondii sugar transporter ST2 0.0014 0.0014 0.0843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0952 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0066 0.1994
Brugia malayi nuclear hormone receptor 0.0016 0.002 0.0011
Echinococcus granulosus tumor protein p63 0.0339 0.1129 0.3247
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0245 0.0372
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0952 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0063 0.0529
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Echinococcus granulosus nAChR subunit 0.0326 0.1082 0.3111
Echinococcus granulosus dna polymerase kappa 0.006 0.0169 0.0467
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Schistosoma mansoni nuclear hormone receptor 0.0016 0.002 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.011 0.1024
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.0855 0.1349
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0082 0.0214
Loa Loa (eye worm) hypothetical protein 0.0039 0.0097 0.0091
Brugia malayi Nuclear hormone receptor E75 0.0016 0.002 0.0011
Schistosoma mansoni cpg binding protein 0.0029 0.0063 0.0275
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0063 0.0222
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0164 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0952 1
Echinococcus multilocularis dna polymerase eta 0.0034 0.008 0.026
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0187 0.0651
Leishmania major hypothetical protein, conserved 0.0014 0.0014 0.0417
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0014 0.0156
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0605 0.204 0.7383
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0046 0.0068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0097 0.009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0082 0.0358
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0022 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Schistosoma mansoni glucose transport protein 0.0014 0.0014 0.006
Onchocerca volvulus 0.0034 0.0082 0.0337
Schistosoma mansoni cpg binding protein 0.003 0.0069 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0082 0.0214
Brugia malayi 6-phosphofructokinase 0.0107 0.0331 0.051
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0014 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0046 0.0068
Brugia malayi hypothetical protein 0.0279 0.0922 0.1456
Schistosoma mansoni lamin 0.0027 0.0055 0.0241
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0605 0.204 0.8887
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0279 0.0922 0.1456
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0082 0.0214
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0097 0.0256
Brugia malayi glutaminase DH11.1 0.0269 0.0888 0.1402
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0082 0.0076
Trypanosoma brucei glucose transporter, putative 0.0014 0.0014 0.0417
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0331 0.2773
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.002 0.0034
Echinococcus granulosus muscleblind protein 0.015 0.0479 0.1364
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0331 0.3733
Loa Loa (eye worm) hypothetical protein 0.0039 0.0097 0.009
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0014 0.0417
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0605 0.204 0.3248
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0331 0.3387
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0082 0.0214
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Echinococcus granulosus nAChR subunit 0.0605 0.204 0.5884
Schistosoma mansoni hypothetical protein 0.0036 0.0088 0.0384
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.002 0.0086
Plasmodium falciparum hexose transporter 0.0014 0.0014 0.1418
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.0434
Brugia malayi nuclear receptor RXR 0.0016 0.002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0548 0.5701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0082 0.0076
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0063 0.387
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0046 0.0053
Leishmania major DNA polymerase eta, putative 0.0034 0.008 0.2402
Echinococcus granulosus dna polymerase eta 0.0034 0.008 0.0207
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0063 0.0529
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Schistosoma mansoni hypothetical protein 0.0039 0.0097 0.0424
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0097 0.0256
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0025 0.2593
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0456
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0014 0.0014 0.0016
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0279 0.0922 0.3319
Trichomonas vaginalis glutaminase, putative 0.0269 0.0888 0.9319
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0605 0.204 0.5884
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0128
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0605 0.204 0.8887
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0605 0.204 0.7383
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0187 0.0815
Onchocerca volvulus 0.0039 0.0097 0.0412
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0605 0.204 0.3248
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0097 0.0321
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0304 0.1074
Loa Loa (eye worm) hypothetical protein 0.0326 0.1082 0.1077
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0135 0.0587
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0605 0.204 0.3248
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Leishmania major glucose transporter/membrane transporter D2, putative 0.0014 0.0014 0.0417
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0279 0.0922 0.1456
Loa Loa (eye worm) hypothetical protein 0.0034 0.008 0.0073
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0605 0.204 0.3248
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0605 0.204 0.7383
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0014 0.0417
Schistosoma mansoni glucose transport protein 0.0014 0.0014 0.006
Loa Loa (eye worm) hypothetical protein 0.0326 0.1082 0.1077
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0103
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0097 0.5899
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0855 0.8966
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0331 0.0936
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0331 0.7339
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Echinococcus multilocularis solute carrier family 22 0.0014 0.0014 0.0021
Mycobacterium ulcerans glutaminase 0.0269 0.0888 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0046 0.0517
Loa Loa (eye worm) glutaminase 2 0.0269 0.0888 0.0882
Trypanosoma brucei unspecified product 0.0053 0.0147 0.4441
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0014 0.0001
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0245 0.0861
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.002
Echinococcus multilocularis tumor protein p63 0.0339 0.1129 0.4074
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0046 0.0053
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0014 0.0417
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0108 0.6605
Onchocerca volvulus 0.0326 0.1082 0.5274
Brugia malayi major facilitator superfamily protein 0.0014 0.0014 0.0001
Echinococcus granulosus solute carrier family 22 0.0014 0.0014 0.0016
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.011 0.037
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0952 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0815 0.276 1
Schistosoma mansoni nAChR subunit 0.0605 0.204 0.8887
Brugia malayi nuclear receptor NHR-88 0.0034 0.0082 0.0111
Echinococcus multilocularis expressed conserved protein 0.0093 0.0283 0.0999
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0055 0.0049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0082 0.0358
Trypanosoma brucei glucose transporter 1E 0.0014 0.0014 0.0417
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.002 0.0011
Trypanosoma cruzi hexose transporter 0.0014 0.0014 0.0417
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0076
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0331 0.0325
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0026 0.0067
Schistosoma mansoni inositol transporter 0.0039 0.0097 0.0421
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.008 0.0347
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0063 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0279 0.0922 0.2646
Brugia malayi excitatory GABA receptor EXP-1A 0.0605 0.204 0.3248
Echinococcus granulosus solute carrier family 22 0.0014 0.0014 0.0016
Schistosoma mansoni sugar transporter 0.0014 0.0014 0.006
Echinococcus granulosus lamin dm0 0.0027 0.0055 0.0137
Brugia malayi hypothetical protein 0.0014 0.0014 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0046 0.1386
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0605 0.204 0.2035
Echinococcus granulosus glycine receptor subunit beta 0.0605 0.204 0.5884
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0279 0.0922 0.0916
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0046 0.0517
Brugia malayi hypothetical protein 0.0279 0.0922 0.1456
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0082 0.0269
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0043 0.1303
Schistosoma mansoni rab6-interacting 0.0039 0.0097 0.0424
Echinococcus multilocularis solute carrier family 22 0.0014 0.0014 0.0021
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.008 0.2402
Schistosoma mansoni intermediate filament proteins 0.0027 0.0055 0.0241
Brugia malayi hypothetical protein 0.0279 0.0922 0.1456
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.009 0.2711
Echinococcus multilocularis musashi 0.0027 0.0055 0.0171
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0108 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0063 0.0529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0082 0.0076
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0449 0.1278
Echinococcus granulosus Solute carrier family 22 5 0.1019 0.3461 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0082 0.0269
Echinococcus granulosus microtubule associated protein 2 0.0679 0.2296 0.6624
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0043 0.0678
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.0952 0.8741
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0014 0.0021
Brugia malayi steroid hormone receptor 0.0034 0.0082 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.002 0.0042
Brugia malayi hypothetical protein 0.0016 0.002 0.0011
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0605 0.204 0.5884
Schistosoma mansoni inositol transporter 0.0039 0.0097 0.0421
Brugia malayi POT family protein 0.004 0.0102 0.0143
Loa Loa (eye worm) hypothetical protein 0.0326 0.1082 0.1077
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0082 0.0076
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0014 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0082 0.0111
Schistosoma mansoni nAChR subunit 0.0605 0.204 0.8887
Schistosoma mansoni hypothetical protein 0.0014 0.0014 0.006
Onchocerca volvulus 0.0029 0.0063 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0026 0.0115
Leishmania major glucose transporter, lmgt2 0.0014 0.0014 0.0417
Brugia malayi Cation transporter family protein 0.0605 0.204 0.3248
Onchocerca volvulus 0.0279 0.0922 0.4481
Onchocerca volvulus 0.0605 0.204 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0076
Schistosoma mansoni neurotransmitter gated ion channel 0.0326 0.1082 0.4715
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0605 0.204 0.8887
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0169 0.5113
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0093 0.0309
Schistosoma mansoni sodium/solute symporter 0.0039 0.0097 0.0421
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0063 0.0194
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0605 0.204 0.5884
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0025 0.2335
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0082 0.0111
Onchocerca volvulus 0.0027 0.0055 0.0205
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.011 0.0103
Echinococcus multilocularis solute carrier family 5 0.0039 0.0097 0.0321
Brugia malayi GH02984p 0.0039 0.0097 0.0134
Brugia malayi nuclear receptor NHR-88 0.0016 0.002 0.0011
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0605 0.204 0.3248
Trypanosoma brucei glucose transporter, putative 0.0014 0.0014 0.0417
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0063 0.0529
Schistosoma mansoni lipoxygenase 0.017 0.0549 0.2392
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0014 0.0417
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0063 0.387
Mycobacterium ulcerans hypothetical protein 0.0024 0.0046 0.0517
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0014 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0055 0.0049
Schistosoma mansoni nAChR subunit 0.0279 0.0922 0.4015
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.002 0.0034
Loa Loa (eye worm) DR-78 0.0016 0.002 0.0013
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0063 0.0529
Brugia malayi ecdysteroid receptor 0.0034 0.0082 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0169 0.5113
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0169 0.1909
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0013 0.0007
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0605 0.204 0.5884
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.008 0.2402
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0014 0.0417
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0076
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0043 0.3991
Schistosoma mansoni nuclear hormone receptor 0.0016 0.002 0.0086
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0014 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0605 0.204 0.3248
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0014 0.0014 0.0021
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0097 0.9004
Echinococcus granulosus expressed conserved protein 0.0093 0.0283 0.0796
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.002
Schistosoma mansoni nAChR subunit 0.0605 0.204 0.8887
Brugia malayi hypothetical protein 0.0039 0.0097 0.0135
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Brugia malayi Muscleblind-like protein 0.015 0.0479 0.0747
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0082 0.0214
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0082 0.0269
Echinococcus multilocularis glycine receptor subunit beta 0.0605 0.204 0.7383
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0014 0.0843
Onchocerca volvulus 0.0016 0.002 0.003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.044 0.1251
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Loa Loa (eye worm) POT family protein 0.004 0.0102 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0066 0.1994
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.058 0.6037
Onchocerca volvulus 0.0605 0.204 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.002 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0082 0.0111
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0082 0.0358
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0605 0.204 0.3248
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0097 0.0134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.1832 0.6254 0.6252
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0304 0.0856
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0174 0.0759
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0082 0.0111
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0014 0.006
Schistosoma mansoni lamin 0.0027 0.0055 0.0241
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0169 0.5113
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0447 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0279 0.0922 0.1456
Loa Loa (eye worm) hypothetical protein 0.0039 0.0097 0.0091
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0331 0.1444
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0605 0.204 0.7383
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0082 0.0269
Schistosoma mansoni glucose transporter 0.0014 0.0014 0.006
Brugia malayi hypothetical protein 0.0016 0.002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0082 0.0111
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0605 0.204 0.2035
Onchocerca volvulus 0.0027 0.0055 0.0205
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0014 0.0001
Schistosoma mansoni nAChR subunit 0.0605 0.204 0.8887
Loa Loa (eye worm) hypothetical protein 0.0099 0.0304 0.0297
Loa Loa (eye worm) ACC-1 protein 0.0605 0.204 0.2035
Loa Loa (eye worm) hypothetical protein 0.0326 0.1082 0.1077
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0245 0.1068
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0082 0.0337
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Brugia malayi nuclear receptor NHR-67 0.0016 0.002 0.0011
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0456
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Echinococcus multilocularis RUN 0.0039 0.0097 0.0324
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0097 0.0258
Loa Loa (eye worm) GABA receptor subunit 0.0326 0.1082 0.1077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0046 0.0742
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.1375 0.4965
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0026 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0548 0.5701
Echinococcus granulosus intermediate filament protein 0.0027 0.0055 0.0137
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0447 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Echinococcus granulosus lamin 0.0027 0.0055 0.0137
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0014 0.0156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.0039
Leishmania major glucose transporter, lmgt1 0.0014 0.0014 0.0417
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0046 0.0517
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0046 0.1386
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Loa Loa (eye worm) sugar transporter 0.0014 0.0014 0.0007
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0097 0.0324
Onchocerca volvulus 0.0039 0.0097 0.0412
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0187 0.5648
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0169 0.1909
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0096 0.051
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0093 0.0247
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.002
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.0434
Schistosoma mansoni cpg binding protein 0.003 0.0069 0.03
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0454 0.1619
Schistosoma mansoni zinc finger protein 0.0016 0.002 0.0086
Echinococcus granulosus cpg binding protein 0.003 0.0069 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0082 0.0111
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0605 0.204 0.3248
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0605 0.204 0.3248
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0043 0.4433
Leishmania major DNA polymerase kappa, putative 0.004 0.0102 0.3075
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0326 0.1082 0.1714
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0605 0.204 0.5884
Loa Loa (eye worm) hypothetical protein 0.0326 0.1082 0.1077
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0022 0.1361
Echinococcus multilocularis lamin 0.0027 0.0055 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0022 0.0187
Echinococcus granulosus glycine receptor subunit alpha 1 0.0605 0.204 0.5884
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.0434
Loa Loa (eye worm) hypothetical protein 0.0037 0.009 0.0083
Brugia malayi tailless protein 0.0016 0.002 0.0011
Schistosoma mansoni high-affinity choline transporter 0.0039 0.0097 0.0421
Trypanosoma brucei glucose transporter, putative 0.0014 0.0014 0.0417
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0046 0.1386
Brugia malayi conserved hypotetical protein 0.0016 0.002 0.0011
Schistosoma mansoni loxhd1 0.0039 0.0097 0.0424
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0605 0.204 0.8887
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0082 0.0214
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Schistosoma mansoni DNA polymerase eta 0.0034 0.008 0.0347
Echinococcus multilocularis solute carrier family 22 0.0014 0.0014 0.0021
Loa Loa (eye worm) glutaminase 0.0269 0.0888 0.0882
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0088 0.0384
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0014 0.0014 0.0021
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.1832 0.6254 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0043 0.4699
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.011 0.0295
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0279 0.0922 0.1456
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0096 0.1011
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0331 1
Brugia malayi Sugar transporter family protein 0.0014 0.0014 0.0001
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0097 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0019
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0605 0.204 0.3248
Echinococcus multilocularis cpg binding protein 0.003 0.0069 0.0221
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0309 0.1346
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0169 0.5113
Loa Loa (eye worm) hypothetical protein 0.0326 0.1082 0.1077
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0063 0.6508
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0855 0.8966
Loa Loa (eye worm) sugar transporter 0.0014 0.0014 0.0007
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0187 0.1386
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0331 0.2773
Loa Loa (eye worm) acetyltransferase 0.0143 0.0454 0.0448
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0043 0.2636
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.008 0.1521
Trypanosoma brucei glucose transporter 2A 0.0014 0.0014 0.0417
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.0952 0.8741
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0063 0.0529
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0605 0.204 0.3248
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0013
Schistosoma mansoni nuclear receptor 0.0016 0.002 0.0086
Echinococcus multilocularis protein patched 0.0042 0.011 0.037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0187 0.0279
Plasmodium vivax hexose transporter 0.0014 0.0014 0.1277
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0046 0.0517
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.2296 0.8311
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0454 0.0706
Entamoeba histolytica hypothetical protein 0.0326 0.1082 1
Onchocerca volvulus 0.0279 0.0922 0.4481
Echinococcus multilocularis lamin dm0 0.0027 0.0055 0.0171
Echinococcus granulosus RUN 0.0039 0.0097 0.0258
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0082 0.0358
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0279 0.0922 0.3319
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0331 0.3387
Onchocerca volvulus Putative nachr subunit 0.0605 0.204 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.015 0.0479 0.0473
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0331 0.0325
Schistosoma mansoni nAChR subunit 0.0279 0.0922 0.4015
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0108 0.6605
Echinococcus granulosus glycine receptor subunit alpha 1 0.0605 0.204 0.5884
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Loa Loa (eye worm) hypothetical protein 0.0279 0.0922 0.0916
Loa Loa (eye worm) hypothetical protein 0.0605 0.204 0.2035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0019
Brugia malayi Nuclear hormone receptor E75 0.0016 0.002 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0605 0.204 0.3248
Echinococcus multilocularis glycine receptor subunit beta 0.0605 0.204 0.7383
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0605 0.204 0.2035
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0605 0.204 0.7383
Brugia malayi nuclear hormone receptor 0.0034 0.0082 0.0111
Echinococcus multilocularis high affinity choline transporter 1 0.0039 0.0097 0.0321
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0605 0.204 0.2035
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0326 0.1082 0.4715
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0096 0.9875
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0952 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0169 0.5113
Echinococcus multilocularis muscleblind protein 0.015 0.0479 0.1712
Loa Loa (eye worm) LGC-31 protein 0.0605 0.204 0.2035
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0331 0.1444
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0063 0.5859
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0169 0.5113
Schistosoma mansoni glutaminase 0.0269 0.0888 0.3867
Loa Loa (eye worm) hypothetical protein 0.0326 0.1082 0.1077
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0043 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0014 0.0016

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.82 nM Agonist activity at human PRB expressed in CHO cells ChEMBL. 18243712
EC50 (functional) = 0.82 nM Agonist activity at human PRB expressed in CHO cells ChEMBL. 18243712
Efficacy (functional) = 36 % Agonist activity at human PRB expressed in CHO cells relative to Org 2058 ChEMBL. 18243712
Efficacy (functional) = 36 % Agonist activity at human PRB expressed in CHO cells relative to Org 2058 ChEMBL. 18243712
Efficacy (functional) = 66 % Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation relative to Org 31710 ChEMBL. 18243712
Efficacy (functional) = 66 % Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation relative to Org 31710 ChEMBL. 18243712
IC50 (functional) = 0.75 nM Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation ChEMBL. 18243712
IC50 (functional) = 0.75 nM Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation ChEMBL. 18243712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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