Detailed information for compound 558155

Basic information

Technical information
  • TDR Targets ID: 558155
  • Name: (1S,6R,8R,9R)-8-(6,8-diaminopurin-9-yl)-3-hyd roxy-3-oxo-2,4,7-trioxa-3$l^{5}-phosphabicycl o[4.3.0]nonan-9-ol
  • MW: 344.221 | Formula: C10H13N6O6P
  • H donors: 4 H acceptors: 6 LogP: -2.9 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@@H]2OP(=O)(O)OC[C@H]2O[C@H]1n1c(N)nc2c1ncnc2N
  • InChi: 1S/C10H13N6O6P/c11-7-4-8(14-2-13-7)16(10(12)15-4)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H2,12,15)(H,18,19)(H2,11,13,14)/t3-,5-,6-,9-/m1/s1
  • InChiKey: XKAQQTTUGGGUIZ-UUOKFMHZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S,6R,8R,9R)-8-(6,8-diamino-9-purinyl)-3-hydroxy-3-oxo-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-9-ol
  • (1S,6R,8R,9R)-8-[6,8-bis(azanyl)purin-9-yl]-3-hydroxy-3-oxo-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-9-ol
  • (1S,6R,8R,9R)-8-(6,8-diaminopurin-9-yl)-3-hydroxy-3-keto-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-9-ol
  • 8-aminoadenosine 3',5'-monophosphate
  • 30685-40-6
  • Adenosine, 8-amino-, cyclic 3',5'-(hydrogen phosphate)
  • 8-Amino-cyclic amp

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum ribonuclease Z 0.0016 0.0116 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0065 0.0601
Schistosoma mansoni myo inositol monophosphatase 0.0008 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0056
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0024 0.0052
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0113 0.0206
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0008 0.0025 0.0205
Giardia lamblia Cyclin A 0.0018 0.014 0.1154
Brugia malayi hypothetical protein 0.0072 0.079 0.1482
Brugia malayi WGR domain containing protein 0.0079 0.088 0.1652
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0116 0.1095
Schistosoma mansoni hypothetical protein 0.0397 0.4674 1
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0008 0.0025 0.0205
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0359 0.3341
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0013 0.0028
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0124 0.1408 0.2124
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0553 0.6536 1
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0116 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1026 0.1927
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1315 0.2472
Trichomonas vaginalis apoptosis inducing factor, putative 0.0016 0.0116 0.1095
Mycobacterium ulcerans beta lactamase-like protein 0.0016 0.0116 0.014
Trichomonas vaginalis cyclin D, putative 0.0018 0.014 0.1336
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0211
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0116 0.0247
Trypanosoma cruzi cyclin, putative 0.0018 0.014 0.1336
Entamoeba histolytica hypothetical protein 0.0072 0.079 0.475
Entamoeba histolytica zinc finger protein, putative 0.0011 0.0058 0.0331
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0004 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.079 0.1482
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0024 0.0039
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0008 0.0025 0.0205
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1026 0.2194
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0033 0.0327 0.0323
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0008 0.0025 0.0205
Echinococcus granulosus poly (ADP ribose) polymerase 0.0045 0.0467 0.0874
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0033 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0461 0.0862
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0024 0.0039
Mycobacterium ulcerans glyoxalase II, GloB 0.0016 0.0116 0.014
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Loa Loa (eye worm) hypothetical protein 0.0067 0.0737 0.1382
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0199 0.0368
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Mycobacterium ulcerans hydrolase 0.0016 0.0116 0.014
Onchocerca volvulus 0.0028 0.0263 0.0757
Brugia malayi ethe1-prov protein 0.0016 0.0116 0.0211
Brugia malayi hypothetical protein 0.0016 0.0116 0.0211
Brugia malayi Muscleblind-like protein 0.045 0.5307 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Entamoeba histolytica hypothetical protein 0.0072 0.079 0.475
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.014 0.1336
Trypanosoma brucei DNA repair protein, putative 0.0019 0.0156 0.0949
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0199 0.0368
Echinococcus granulosus smad 0.0008 0.0024 0.0039
Chlamydia trachomatis ribonuclease Z 0.0016 0.0116 1
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0079 0.088 0.8573
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0601
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0113 0.011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0206
Schistosoma mansoni hypothetical protein 0.0176 0.2034 0.4353
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0025 0.0127
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0033 0.0056
Onchocerca volvulus Putative hydrolase PNKD 0.0016 0.0116 0.0326
Entamoeba histolytica hypothetical protein 0.0022 0.0199 0.1178
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0222 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0065 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0156 0.1489
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0033 0.0071
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0024 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.079 0.169
Brugia malayi hypothetical protein 0.0024 0.0222 0.0413
Leishmania major hypothetical protein, conserved 0.0022 0.0188 0.1633
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0033 0.0071
Echinococcus multilocularis geminin 0.0176 0.2034 0.2032
Schistosoma mansoni cpg binding protein 0.0029 0.0282 0.0604
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0112
Schistosoma mansoni smad 0.0008 0.0024 0.0052
Entamoeba histolytica hypothetical protein 0.0072 0.079 0.475
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0116 0.0676
Onchocerca volvulus 0.0018 0.014 0.0398
Echinococcus multilocularis cyclin B 0.0018 0.014 0.0137
Loa Loa (eye worm) hypothetical protein 0.0008 0.0025 0.004
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0079 0.088 0.8573
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0461 0.0457
Echinococcus multilocularis cyclin B3 1 0.0018 0.014 0.0137
Brugia malayi Smad1 0.0008 0.0024 0.0039
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0039
Brugia malayi MH1 domain containing protein 0.0008 0.0024 0.0039
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0263 0.0489
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0008 0.0025 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0461 0.0862
Mycobacterium ulcerans hypothetical protein 0.0016 0.0116 0.014
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0116 0.1095
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0033 0.0086
Schistosoma mansoni hypothetical protein 0.0016 0.0116 0.0247
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0831 0.8059
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1025 0.1927
Echinococcus granulosus tar DNA binding protein 0.0071 0.0778 0.146
Trichomonas vaginalis A-type flavoprotein 0.0016 0.0116 0.1095
Trypanosoma cruzi DNA repair protein, putative 0.0019 0.0156 0.1489
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0016 0.0116 0.0247
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0116 0.014
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0052
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0013 0.0009
Entamoeba histolytica cyclin family protein 0.0018 0.014 0.0825
Loa Loa (eye worm) Smad1 0.0008 0.0024 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0461 0.0986
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0013 0.0009
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0018 0.014 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0472 0.4587
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Echinococcus multilocularis cyclin b3 0.0018 0.014 0.0137
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0188 0.1182
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0561 0.3153
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Echinococcus granulosus WGR domain containing protein 0.0045 0.0467 0.0874
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0359 0.3478
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1026 0.1927
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0145 0.1659 0.3549
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0359 0.067
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0033 0.0056
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0325 0.0607
Onchocerca volvulus 0.0016 0.0116 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Loa Loa (eye worm) hypothetical protein 0.0048 0.0508 0.0952
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0331
Schistosoma mansoni hypothetical protein 0.0072 0.079 0.169
Leishmania major DNA repair protein, putative 0.0019 0.0156 0.1311
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0778 0.146
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0116 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Loa Loa (eye worm) tnks protein 0.0011 0.0058 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Schistosoma mansoni tankyrase 0.0011 0.0058 0.0125
Trypanosoma brucei glyoxalase II 0.0016 0.0116 0.0658
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0018 0.014 0.1154
Trichomonas vaginalis cyclin D, putative 0.0018 0.014 0.1336
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0061 0.0109
Onchocerca volvulus 0.0016 0.0116 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0601
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0211
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0067 0.0737 0.1382
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0535
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0222 0.1163
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0211
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0199 0.0368
Trichomonas vaginalis hypothetical protein 0.0033 0.0323 0.3125
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0359 0.2418
Brugia malayi MH2 domain containing protein 0.0008 0.0024 0.0039
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0124 0.1408 0.2124
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0331
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0025 0.004
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0016 0.0116 0.0211
Schistosoma mansoni dishevelled 0.0009 0.0033 0.0071
Plasmodium falciparum cyclin 0.0018 0.014 0.2296
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0331
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0188 0.1805
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.014 0.0257
Onchocerca volvulus 0.0009 0.0033 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0156 0.0287
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0359 0.3478
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0116 0.0211
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0061 0.0058
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Mycobacterium ulcerans hypothetical protein 0.0016 0.0116 0.014
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0116 0.0676
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0025 0.0127
Trypanosoma brucei polo-like protein kinase 0.0092 0.1026 0.7238
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0033 0.0056
Echinococcus granulosus ETHE1 protein 0.0016 0.0116 0.0211
Trypanosoma brucei mitotic cyclin 6 0.0018 0.014 0.0835
Leishmania major metallo-beta-lactamase family-like protein 0.0016 0.0116 0.0909
Entamoeba histolytica cyclin, putative 0.0018 0.014 0.0825
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0016 0.0116 0.0909
Schistosoma mansoni pap-inositol-14-phosphatase 0.0008 0.0025 0.0053
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0116 0.0247
Schistosoma mansoni inositol monophosphatase 0.0075 0.0831 0.1779
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0293
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0371
Entamoeba histolytica cyclin, putative 0.0018 0.014 0.0825
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0067 0.0737 0.0733
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1315 0.2472
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0778 0.146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0508 0.0952
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1025 0.1022
Brugia malayi MH2 domain containing protein 0.0116 0.1315 0.2472
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0508 0.0952
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0025 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Brugia malayi Inositol-1 0.0075 0.0831 0.1561
Schistosoma mansoni dishevelled 0.0009 0.0033 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0359 0.3478
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0211
Leishmania major cyclin 0.0018 0.014 0.1154
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0116 0.0676
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0079 0.088 0.0876
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Brugia malayi hypothetical protein 0.0009 0.0033 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0211
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0359 0.0356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0461 0.0986
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1026 0.6175
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0033 0.0056
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0033 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0461 0.0986
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0033 0.0056
Echinococcus granulosus poly adp ribose polymerase 2 0.0079 0.088 0.1652
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0145 0.1659 1
Mycobacterium tuberculosis Beta lactamase like protein 0.0016 0.0116 0.014
Schistosoma mansoni cyclin B3 0.0018 0.014 0.03
Loa Loa (eye worm) hypothetical protein 0.0008 0.0025 0.004
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0359 0.0356
Schistosoma mansoni cyclins 0.0018 0.014 0.03
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0831 0.4741
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0116 0.1095
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1026 0.1022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0116 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0116 0.0211
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0371
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0116 0.014
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0359 0.3478
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0222 0.1431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0461 0.0862
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0033 0.0056
Trypanosoma cruzi CYC2-like cyclin, putative 0.0018 0.014 0.1336
Brugia malayi RNA binding protein 0.0071 0.0778 0.146
Echinococcus granulosus cyclin B 0.0018 0.014 0.0257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Echinococcus granulosus geminin 0.0176 0.2034 0.3829
Loa Loa (eye worm) cyclin domain-containing protein 0.0018 0.014 0.0257
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0359 0.067
Echinococcus multilocularis zinc phosphodiesterase 0.0016 0.0116 0.0112
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0033 0.0056
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0013 0.0018
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0033 0.003
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0116 0.0112
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0113 0.0206
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4674 0.8806
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0472 0.4587
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0211
Schistosoma mansoni hypothetical protein 0.0016 0.0116 0.0247
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0033 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.002
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Toxoplasma gondii hypothetical protein 0.0013 0.0089 0.0381
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0113 0.0206
Echinococcus granulosus inositol monophosphatase 0.0008 0.0025 0.004
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0018 0.014 0.0257
Echinococcus granulosus Smad4 0.0008 0.0024 0.0039
Echinococcus granulosus zinc phosphodiesterase 0.0016 0.0116 0.0211
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1026 0.1927
Mycobacterium ulcerans lipoprotein LpqF 0.0124 0.1408 0.2124
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Entamoeba histolytica hypothetical protein 0.0072 0.079 0.475
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0778 0.146
Loa Loa (eye worm) inositol-1 0.0075 0.0831 0.1561
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0508 0.0952
Schistosoma mansoni hypothetical protein 0.0016 0.0116 0.0247
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0116 0.1095
Echinococcus granulosus GPCR family 2 0.0015 0.0113 0.0206
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0211
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0113 0.0206
Schistosoma mansoni hypothetical protein 0.0011 0.0061 0.0131
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Mycobacterium ulcerans hydrolase 0.0016 0.0116 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Echinococcus multilocularis ETHE1 protein 0.0016 0.0116 0.0112
Leishmania major metallo-beta-lactamase family protein-like protein 0.0016 0.0116 0.0909
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0116 0.0676
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0016 0.0116 0.0535
Schistosoma mansoni tsg101-related 0.0056 0.0602 0.1287
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Brugia malayi hypothetical protein 0.0293 0.3435 0.647
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0033 0.0056
Giardia lamblia Kinase, PLK 0.0092 0.1026 1
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0778 0.0775
Schistosoma mansoni hypothetical protein 0.0176 0.2034 0.4353
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0052
Mycobacterium tuberculosis Conserved protein 0.0016 0.0116 0.014
Leishmania major hypothetical protein, conserved 0.0016 0.0116 0.0909
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Brugia malayi Tnks protein 0.0011 0.0058 0.0103
Onchocerca volvulus 0.0293 0.3435 1
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0222 0.2142
Trypanosoma cruzi cyclin, putative 0.0018 0.014 0.1336
Entamoeba histolytica type A flavoprotein, putative 0.0016 0.0116 0.0676
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0024 0.0021
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0831 1
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0553 0.6536 1
Schistosoma mansoni hypothetical protein 0.0092 0.1028 0.2201
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0909
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0116 0.1095
Entamoeba histolytica alkyl sulfatase, putative 0.0016 0.0116 0.0676
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0461 0.0457
Schistosoma mansoni hypothetical protein 0.0015 0.0113 0.0242
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Loa Loa (eye worm) hypothetical protein 0.011 0.1246 0.2342
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Echinococcus multilocularis inositol monophosphatase 0.0008 0.0025 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0222 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Trypanosoma cruzi cyclin 6, putative 0.0018 0.014 0.1336
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1026 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.014 0.0257
Schistosoma mansoni tsg101-related 0.0056 0.0602 0.1287
Echinococcus multilocularis cpg binding protein 0.0029 0.0282 0.0279
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0831 0.8099
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0258 0.3008 0.4582
Echinococcus granulosus muscleblind protein 0.045 0.5307 1
Schistosoma mansoni inositol monophosphatase 0.0075 0.0831 0.1779
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.079 0.0786
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0032 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.014 0.0257
Giardia lamblia Hypothetical protein 0.0018 0.014 0.1154
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1026 1
Trichomonas vaginalis beta lactamase domain, putative 0.0016 0.0116 0.1095
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0359 0.067
Loa Loa (eye worm) hypothetical protein 0.0079 0.088 0.1652
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Leishmania major hypothetical protein, conserved 0.0024 0.0222 0.1977
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0004 0.0008
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0737 0.1094
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0056
Trypanosoma cruzi glyoxalase II 0.0016 0.0116 0.1095
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.014 0.0257
Schistosoma mansoni hypothetical protein 0.0033 0.0325 0.0696
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0013 0.0018
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0016 0.0116 0.0658
Brugia malayi WGR domain containing protein 0.0145 0.1659 0.3121
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0016 0.0116 0.0658
Echinococcus granulosus cyclins 0.0018 0.014 0.0257
Echinococcus multilocularis muscleblind protein 1 0.045 0.5307 0.5305
Onchocerca volvulus DNA ligase 3 homolog 0.0019 0.0156 0.0444
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0008 0.0025 0.0021
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.014 0.0257
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0211
Giardia lamblia G2/mitotic-specific cyclin B 0.0018 0.014 0.1154
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0479 0.2871
Brugia malayi hypothetical protein 0.0009 0.0033 0.0056
Mycobacterium ulcerans hypothetical protein 0.0016 0.0116 0.014
Echinococcus multilocularis GPCR, family 2 0.0015 0.0113 0.011
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Schistosoma mansoni hypothetical protein 0.0015 0.0113 0.0242
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0359 0.3478
Schistosoma mansoni hypothetical protein 0.0008 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.0175 0.2024 0.3809
Mycobacterium tuberculosis Conserved protein 0.0016 0.0116 0.014
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0069 0.0752 0.1608
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Trypanosoma cruzi glyoxalase II 0.0016 0.0116 0.1095
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1025 0.1022
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0222 0.2142
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0371
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0831 0.8099
Schistosoma mansoni hypothetical protein 0.0008 0.0025 0.0053
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0553 0.6536 1
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0371
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0065 0.0601
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0016 0.0116 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Schistosoma mansoni hypothetical protein 0.0015 0.0113 0.0242
Schistosoma mansoni cpg binding protein 0.0029 0.0282 0.0604
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0004 0.0008
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0359 0.0768
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Mycobacterium ulcerans hydrolase 0.0016 0.0116 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1026 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1026 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0359 0.0356
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0056
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0325 0.0607
Echinococcus multilocularis smad 0.0008 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0293 0.3435 0.647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0461 0.0862
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.002
Echinococcus granulosus cyclin B3 1 0.0018 0.014 0.0257
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0033 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0831 0.8099
Echinococcus multilocularis muscleblind protein 0.045 0.5307 0.5305
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0024 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.002
Trichomonas vaginalis cyclin B, putative 0.0018 0.014 0.1336
Onchocerca volvulus Tankyrase homolog 0.0011 0.0058 0.0159
Toxoplasma gondii hypothetical protein 0.0009 0.0033 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0113 0.0206
Echinococcus granulosus cpg binding protein 0.0029 0.0282 0.0525
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0831 0.5833
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0778 0.1664
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0116 0.1095
Schistosoma mansoni kinase 0.0047 0.0487 0.1042
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0016 0.0116 0.0326
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0737 0.1094
Entamoeba histolytica cyclin family protein 0.0018 0.014 0.0825
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Mycobacterium ulcerans hypothetical protein 0.0016 0.0116 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.0413
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0222 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0359 0.067
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0116 0.1095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0637 0.1362
Echinococcus granulosus cyclin b3 0.0018 0.014 0.0257
Brugia malayi CXXC zinc finger family protein 0.0028 0.0263 0.0489
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0033 0.003
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0359 0.0768
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0831 0.5001
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1025 0.1927
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0831 0.1239
Leishmania major hypothetical protein, conserved 0.0019 0.0156 0.1311
Trypanosoma cruzi glyoxalase II 0.0016 0.0116 0.1095
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0116 0.0112
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0057 0.0611 0.1146
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0016 0.0116 0.0211
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0831 0.8099
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0831 0.0828
Brugia malayi N-terminal motif family protein 0.0175 0.2024 0.3809
Mycobacterium leprae POSSIBLE HYDROLASE 0.0016 0.0116 0.014
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4674 0.4672
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0116 0.014
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0831 0.1561
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0116 0.014
Trichomonas vaginalis cyclin B3, putative 0.0018 0.014 0.1336
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0359 0.3341
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0113 0.011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0831 0.8099
Brugia malayi DIX domain containing protein 0.0009 0.0033 0.0056
Entamoeba histolytica hypothetical protein 0.0011 0.0058 0.0331
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0359 0.2147
Trichomonas vaginalis cyclins, putative 0.0018 0.014 0.1336
Schistosoma mansoni smad1 5 8 and 0.0008 0.0024 0.0052
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0156 0.0949
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0116 0.0211
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0033 0.003
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0024 0.0021
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0909
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.1028 0.1025
Echinococcus granulosus poly ADP ribose polymerase 1 0.0145 0.1659 0.3121
Schistosoma mansoni cyclin B 0.0018 0.014 0.03
Echinococcus granulosus tankyrase 0.0011 0.0058 0.0103
Echinococcus multilocularis Smad4 0.0008 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0359 0.067
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0004 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0116 0.1095
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0016 0.0116 0.0658
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0145 0.1659 0.1656
Trypanosoma brucei poly(adp-ribose) polymerase 0.0079 0.088 0.6183
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0258 0.3008 0.4582
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0025 0.0205
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.002
Echinococcus multilocularis cyclins 0.0018 0.014 0.0137
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0016 0.0116 0.014
Trichomonas vaginalis helicase, putative 0.0006 0.0006 0.002
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0033 0.0056
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0116 0.014
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0016 0.0116 0.0909
Schistosoma mansoni cpg binding protein 0.0028 0.0263 0.0563
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.015 0.1726 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.2024 0.5887
Mycobacterium tuberculosis Conserved protein 0.0016 0.0116 0.014
Loa Loa (eye worm) RNA binding protein 0.0071 0.0778 0.146
Schistosoma mansoni dep domain containing protein 0.0009 0.0033 0.0071
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0079 0.088 0.1882
Brugia malayi TAR-binding protein 0.0071 0.0778 0.146
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0016 0.0116 0.0909
Mycobacterium leprae Beta-lactamase-like protein 0.0016 0.0116 0.014
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1026 0.2978
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0025 0.0205
Schistosoma mansoni hypothetical protein 0.0015 0.0113 0.0242
Echinococcus multilocularis tankyrase 0.0011 0.0058 0.0055
Brugia malayi hypothetical protein 0.0067 0.0737 0.1382
Brugia malayi hypothetical protein 0.0016 0.0119 0.0217
Entamoeba histolytica metallo-beta-lactamase family protein 0.0016 0.0116 0.0676
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.1025 0.1927
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0058 0.0535
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0008 0.0025 0.0061
Trypanosoma brucei beta lactamase 0.0124 0.1408 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0033 0.003
Schistosoma mansoni Smad4 0.0008 0.0024 0.0052
Trichomonas vaginalis cyclin A, putative 0.0018 0.014 0.1336
Loa Loa (eye worm) hypothetical protein 0.045 0.5307 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.045 0.5307 1
Schistosoma mansoni tsg101-related 0.0046 0.0479 0.1024

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 33 uM Inhibition of cAMP phosphodiesterase preparation from bovine heart at a substrate concentration of 0.14 microM ChEMBL. 6245211
IC50 (binding) = 83 uM Inhibition of cAMP phosphodiesterase preparation from rabbit lung at a substrate concentration of 0.14 microM ChEMBL. 6245211

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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